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Search of human proteins with 44681484
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|44681484 cell division cycle associated 2 [Homo sapiens]
(1023 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|44681484 cell division cycle associated 2 [Homo sapiens] 2033 0.0
gi|225543215 antigen identified by monoclonal antibody Ki-67 iso... 55 4e-07
gi|103472005 antigen identified by monoclonal antibody Ki-67 iso... 55 4e-07
gi|87299628 biorientation of chromosomes in cell division 1-like... 54 1e-06
gi|148596992 heart alpha-kinase [Homo sapiens] 49 3e-05
gi|47419936 SFRS protein kinase 1 [Homo sapiens] 42 0.004
gi|109255232 centrosomal protein 170kDa isoform gamma [Homo sapi... 41 0.007
gi|109255230 centrosomal protein 170kDa isoform beta [Homo sapiens] 39 0.025
gi|109255228 centrosomal protein 170kDa isoform alpha [Homo sapi... 39 0.025
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 39 0.033
gi|41055989 M-phase phosphoprotein 8 [Homo sapiens] 38 0.043
gi|42518068 trans-golgi network protein 2 [Homo sapiens] 38 0.056
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 37 0.073
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 37 0.073
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 37 0.095
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 37 0.095
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 37 0.095
gi|38327039 heat shock 70kDa protein 4 [Homo sapiens] 37 0.12
gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens] 37 0.12
gi|24432077 melanoma associated antigen (mutated) 1-like 1 [Homo... 37 0.12
gi|167234419 thyroid hormone receptor associated protein 3 [Homo... 37 0.12
gi|95147342 chromodomain helicase DNA binding protein 9 [Homo sa... 36 0.16
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 36 0.21
gi|20070205 ladinin 1 [Homo sapiens] 36 0.21
gi|160707950 methyl CpG binding protein 2 isoform 2 [Homo sapiens] 35 0.28
gi|4826830 methyl CpG binding protein 2 isoform 1 [Homo sapiens] 35 0.28
gi|117553580 adaptor-related protein complex 3, delta 1 subunit ... 35 0.36
gi|148806891 hypothetical protein LOC54906 [Homo sapiens] 35 0.47
gi|187608809 hypothetical protein LOC23240 isoform 2 [Homo sapiens] 34 0.62
gi|196114949 hypothetical protein LOC23240 isoform 1 [Homo sapiens] 34 0.62
>gi|44681484 cell division cycle associated 2 [Homo sapiens]
Length = 1023
Score = 2033 bits (5266), Expect = 0.0
Identities = 1023/1023 (100%), Positives = 1023/1023 (100%)
Query: 1 MDANSKDKPPETKESAMNNAGNASFILGTGKIVTPQKHAELPPNPCTPDTFKSPLNFSTV 60
MDANSKDKPPETKESAMNNAGNASFILGTGKIVTPQKHAELPPNPCTPDTFKSPLNFSTV
Sbjct: 1 MDANSKDKPPETKESAMNNAGNASFILGTGKIVTPQKHAELPPNPCTPDTFKSPLNFSTV 60
Query: 61 TVEQLGITPESFVRNSAGKSSSYLKKCRRRSAVGARGSPETNHLIRFIARQQNIKNARKS 120
TVEQLGITPESFVRNSAGKSSSYLKKCRRRSAVGARGSPETNHLIRFIARQQNIKNARKS
Sbjct: 61 TVEQLGITPESFVRNSAGKSSSYLKKCRRRSAVGARGSPETNHLIRFIARQQNIKNARKS 120
Query: 121 PLAQDSPSQGSPALYRNVNTLRERISAFQSAFHSIKENEKMTGCLEFSEAGKESEMTDLT 180
PLAQDSPSQGSPALYRNVNTLRERISAFQSAFHSIKENEKMTGCLEFSEAGKESEMTDLT
Sbjct: 121 PLAQDSPSQGSPALYRNVNTLRERISAFQSAFHSIKENEKMTGCLEFSEAGKESEMTDLT 180
Query: 181 RKEGLSACQQSGFPAVLSSKRRRISYQRDSDENLTDAEGKVIGLQIFNIDTDRACAVETS 240
RKEGLSACQQSGFPAVLSSKRRRISYQRDSDENLTDAEGKVIGLQIFNIDTDRACAVETS
Sbjct: 181 RKEGLSACQQSGFPAVLSSKRRRISYQRDSDENLTDAEGKVIGLQIFNIDTDRACAVETS 240
Query: 241 VDLSEISSKLGSTQSGFLVEESLPLSELTETSNALKVADCVVGKGSSDAVSPDTFTAEVS 300
VDLSEISSKLGSTQSGFLVEESLPLSELTETSNALKVADCVVGKGSSDAVSPDTFTAEVS
Sbjct: 241 VDLSEISSKLGSTQSGFLVEESLPLSELTETSNALKVADCVVGKGSSDAVSPDTFTAEVS 300
Query: 301 SDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKPSVKMCLESLQEHCNNLYDDDGTHPSL 360
SDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKPSVKMCLESLQEHCNNLYDDDGTHPSL
Sbjct: 301 SDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKPSVKMCLESLQEHCNNLYDDDGTHPSL 360
Query: 361 ISNLPNCCKEKEAEDEENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTP 420
ISNLPNCCKEKEAEDEENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTP
Sbjct: 361 ISNLPNCCKEKEAEDEENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTP 420
Query: 421 VCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISETL 480
VCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISETL
Sbjct: 421 VCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISETL 480
Query: 481 SGTDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRR 540
SGTDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRR
Sbjct: 481 SGTDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRR 540
Query: 541 KSQETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVP 600
KSQETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVP
Sbjct: 541 KSQETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVP 600
Query: 601 EMTPSIPSIRRLGSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFC 660
EMTPSIPSIRRLGSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFC
Sbjct: 601 EMTPSIPSIRRLGSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFC 660
Query: 661 SYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEE 720
SYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEE
Sbjct: 661 SYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEE 720
Query: 721 RVASDSPKPALTLQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCN 780
RVASDSPKPALTLQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCN
Sbjct: 721 RVASDSPKPALTLQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCN 780
Query: 781 RLMPNSQKDCHCLGDVLIENTKESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGR 840
RLMPNSQKDCHCLGDVLIENTKESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGR
Sbjct: 781 RLMPNSQKDCHCLGDVLIENTKESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGR 840
Query: 841 SLHLEKNGNHTPSSSVGSSVEISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDL 900
SLHLEKNGNHTPSSSVGSSVEISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDL
Sbjct: 841 SLHLEKNGNHTPSSSVGSSVEISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDL 900
Query: 901 ENEGLVWISLPLPSTSQKAKRRTICTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENS 960
ENEGLVWISLPLPSTSQKAKRRTICTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENS
Sbjct: 901 ENEGLVWISLPLPSTSQKAKRRTICTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENS 960
Query: 961 QGPAAGSSDEPGKRRKSFCISTLANTKATSQFKGYRRRSSLNGKGESSLTALERIEHNGE 1020
QGPAAGSSDEPGKRRKSFCISTLANTKATSQFKGYRRRSSLNGKGESSLTALERIEHNGE
Sbjct: 961 QGPAAGSSDEPGKRRKSFCISTLANTKATSQFKGYRRRSSLNGKGESSLTALERIEHNGE 1020
Query: 1021 RKQ 1023
RKQ
Sbjct: 1021 RKQ 1023
>gi|225543215 antigen identified by monoclonal antibody Ki-67
isoform 2 [Homo sapiens]
Length = 2896
Score = 54.7 bits (130), Expect = 4e-07
Identities = 41/137 (29%), Positives = 70/137 (51%), Gaps = 16/137 (11%)
Query: 389 KRKRVTFGEDLSPEVFDESLPANTPLRKGGTPVCKKDFSGLSSLLLEQSPVPEPL----P 444
KR+RV+FG L PE+FDE+LP NTPL++G P +K SL++ PV + + P
Sbjct: 142 KRRRVSFGGHLRPELFDENLPPNTPLKRGEAPTKRK------SLVMHTPPVLKKIIKEQP 195
Query: 445 QPDFDDKGENLENIEPLQVSFAV---LSSPNKSSIS--ETLSGTDTFSSSNNHEKISSPK 499
QP + + ++E S + SP K+ ++ + T +S++ + PK
Sbjct: 196 QPSGKQESGSEIHVEVKAQSLVISPPAPSPRKTPVASDQRRRSCKTAPASSSKSQTEVPK 255
Query: 500 VGRITRTSNRRNQLVSV 516
G ++ N ++ VS+
Sbjct: 256 RGG-RKSGNLPSKRVSI 271
>gi|103472005 antigen identified by monoclonal antibody Ki-67
isoform 1 [Homo sapiens]
Length = 3256
Score = 54.7 bits (130), Expect = 4e-07
Identities = 41/137 (29%), Positives = 70/137 (51%), Gaps = 16/137 (11%)
Query: 389 KRKRVTFGEDLSPEVFDESLPANTPLRKGGTPVCKKDFSGLSSLLLEQSPVPEPL----P 444
KR+RV+FG L PE+FDE+LP NTPL++G P +K SL++ PV + + P
Sbjct: 502 KRRRVSFGGHLRPELFDENLPPNTPLKRGEAPTKRK------SLVMHTPPVLKKIIKEQP 555
Query: 445 QPDFDDKGENLENIEPLQVSFAV---LSSPNKSSIS--ETLSGTDTFSSSNNHEKISSPK 499
QP + + ++E S + SP K+ ++ + T +S++ + PK
Sbjct: 556 QPSGKQESGSEIHVEVKAQSLVISPPAPSPRKTPVASDQRRRSCKTAPASSSKSQTEVPK 615
Query: 500 VGRITRTSNRRNQLVSV 516
G ++ N ++ VS+
Sbjct: 616 RGG-RKSGNLPSKRVSI 631
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 53.5 bits (127), Expect = 1e-06
Identities = 97/446 (21%), Positives = 178/446 (39%), Gaps = 52/446 (11%)
Query: 517 VEESVCNLLNTEVQPCKEKKINRRKSQETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKS 576
VE+ ++ + + ++INR K +E + K K S K KG+G+ SV
Sbjct: 490 VEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSS-------KTKGQGRSSVDLE 542
Query: 577 LYGERDIASKKPLLSPIPELPEVPEMTPSIPSIRRLGSGYFSSNGKLEEVKTPKNPVKRK 636
+ + K + + + +V E ++ R+ S N K K + K
Sbjct: 543 ESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSK----KKQQYEEDSK 598
Query: 637 DLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSS--LGNATSDEDPNTNIMNINENKNI-PK 693
+ L+ SE C K SSS L + + +P+ ++E+ ++ +
Sbjct: 599 ETLK---------------TSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDE 643
Query: 694 AKNKSESENEPKAGTDSPVSCASVTEERVASDSPKPA----LTLQQGQEFSAGGQNAENL 749
KN+S+ E E K T +PV V EE D + + ++ Q+ + +N ++L
Sbjct: 644 NKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHL 703
Query: 750 CQFFKISPDLN--IKCERKDDFLGAAEGKLQCNRLMPNSQK---DC-HCLGDVLIENTKE 803
+ +P L +K E K K + K DC H GD ++ E
Sbjct: 704 KKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSE 763
Query: 804 SKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGRSLHLEKNGNHTPSSSVGSSVEIS 863
+ E+ +K + + + S D K R+S ++ + L K+G + + +
Sbjct: 764 KGLKVEENIQKQSQQTKLSS--DDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVR 821
Query: 864 LENSELFKDLSDAIEQTFQRRNSETKVRRS--TRLQKDLENEGLVWISLPLPSTSQKAKR 921
EN++ + LS ++ +E K RRS +++QKD I+L S S +
Sbjct: 822 KENNKKERRLS------AEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDK 875
Query: 922 RTICTFDSSGFESMSPIKETVSSRQK 947
C DS+ +S +E V ++
Sbjct: 876 ---CDMDSTNMDSNLKPEEVVHKEKR 898
>gi|148596992 heart alpha-kinase [Homo sapiens]
Length = 2170
Score = 48.5 bits (114), Expect = 3e-05
Identities = 106/510 (20%), Positives = 182/510 (35%), Gaps = 61/510 (11%)
Query: 282 VGKGSSDAVSPDTFTAEVSSDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKPSVKMCLE 341
+ + + + +SP F+ + DA D R P + PT L +V +P + +
Sbjct: 743 ISEANDETMSPGVFSRHLPKDARADFREPVAVSVASPEPTDTALTLENVCDEPRDREAVC 802
Query: 342 SLQEHCNNLYDDDGTHPSLISNLPNCCKEKEAEDEE-NFEAPAFLNMRKRKRVTFGEDLS 400
+++ C D GT I +L +K + E + + K + D +
Sbjct: 803 AME--CFEA-GDQGTCFDTIDSLVGRPVDKYSPQEICSVDTELAEGQNKVSDLCSSNDKT 859
Query: 401 PEVFDESLPANTPLRKGGTPVCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLENIE- 459
EVF ++ + T + T KD + + S L + GENL +E
Sbjct: 860 LEVFFQTQVSETSV---STCKSSKDGNSVMSPLFTSTFTLNISHTASEGATGENLAKVEN 916
Query: 460 ---PLQVSFAVLSSPNKSSISETLSGTDTFSSSNN--------HEKISSPKVGRITRTSN 508
PL + S S L T SS NN +K SP T T
Sbjct: 917 STYPLASTVHAGQEQPSPSNSGGLDETQLLSSENNPLVQFKEGGDKSPSPSAADTTATPA 976
Query: 509 RRNQLVSV--------------------VEESVCNLLNTEVQPCKEKKINRRKSQETKCT 548
+ +VS E++ + TEV P K ++ + + T
Sbjct: 977 SYSSIVSFPWEKPTTLTANNECFQATRETEDTSTVTIATEVHPAKYLAVSIPEDKHAGGT 1036
Query: 549 KRALPKKSQVLKSCRKKKGKGKKSVQ-KSLYGERDIASKKPLLSPIPELPEVPEMTPSIP 607
+ P+ S +K + VQ + I S K LL P +P VP +P
Sbjct: 1037 EERFPRAS------HEKVSQFPSQVQLDHILSGATIKSTKELLCRAPSVPGVPHHVLQLP 1090
Query: 608 SIRRLGSGYFSSNG-KLEEVKTPKN-PVKRKDLLRHDPDLHMHQGYDKYDVSEFCSYIKS 665
G G+ S++ +++ + K+ V R D ++ + K V + +
Sbjct: 1091 E----GEGFCSNSPLQVDNLSGDKSQTVDRADFRSYEENFQERGSETKQGVQQ--QSLSQ 1144
Query: 666 SSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESEN--EPKAGTDSPVSCASVT--EER 721
SL + T E +P A + + S ++G + VS + T EE
Sbjct: 1145 QGSLSAPDFQQSLPTTSAAQEERNLVPTAHSPASSREGAGQRSGWGTRVSVVAETAGEED 1204
Query: 722 VASDSPKPALT---LQQGQEFSAGGQNAEN 748
+ S P+L+ L++ +E+ G A N
Sbjct: 1205 SQALSNVPSLSDILLEESKEYRPGNWEAGN 1234
>gi|47419936 SFRS protein kinase 1 [Homo sapiens]
Length = 655
Score = 41.6 bits (96), Expect = 0.004
Identities = 40/175 (22%), Positives = 76/175 (43%), Gaps = 25/175 (14%)
Query: 525 LNTEVQPCKEKKINRRKSQETKCTKRA----LPKKSQVLKSCRKKKGKGKKSVQKSLYGE 580
++T QP K+++ K ++ K ++ L K+ Q ++ K+ G G+K K
Sbjct: 251 VSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQE--- 307
Query: 581 RDIASKKPLLSPIPELP------EVPEMTPSIPSIRRL-------GSGYFSSNGKLEEVK 627
S+ P+ P+ E P E E + +I + L G+ + NG +E +
Sbjct: 308 ---ESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVIN 364
Query: 628 TPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNATSDEDPNTNI 682
+N + LRH DLH D ++++ S++ S + + + + D T I
Sbjct: 365 YTQN--SNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPI 417
>gi|109255232 centrosomal protein 170kDa isoform gamma [Homo sapiens]
Length = 1460
Score = 40.8 bits (94), Expect = 0.007
Identities = 101/474 (21%), Positives = 172/474 (36%), Gaps = 83/474 (17%)
Query: 554 KKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLS-PIPELPEVPEMTPSIPSIRRL 612
K ++LKS + KG KK KSL + +KP + PI +P + + T S PS L
Sbjct: 713 KAEEILKS-QTPKGGDKKESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSSLAL 771
Query: 613 GSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNA 672
+S ++ E R + L DPD M D +++++ N
Sbjct: 772 -----TSASRIRE---------RSESL--DPDSSMDTTLILKDTEAVMAFLEAKLREDNK 815
Query: 673 TSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEERVASDSPKPALT 732
T DE P+T P + E T S +S + ER ++ K +
Sbjct: 816 T-DEGPDT-----------PSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTS 863
Query: 733 LQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCNRLMPNSQKDCHC 792
L + + C S D+ K GA E K++ ++
Sbjct: 864 LYKDR------------CSTGSPSKDVT-----KSSSSGARE-KMEKKTKSRSTDVGSRA 905
Query: 793 LGDVLIENTKESKSQSEDLGRKPMESS---SVVSCRDRKDRRRSMCYSDGRSLHLEKNGN 849
G ++++ + S DL SS S +S D+ C GR
Sbjct: 906 DGRKFVQSSGRIRQPSVDLTDDDQTSSVPHSAISDIMSSDQETYSCKPHGR--------- 956
Query: 850 HTPSSSVGSSVEISLENSELFKDLSDAI-------EQTFQR-RNSETKVRRSTRL----Q 897
TP +S V LE S++ K + + T R R + T + R RL
Sbjct: 957 -TPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPRPTRTSLLRRARLGEASD 1015
Query: 898 KDLENEGLVWISLPLPSTSQKAK----RRTICTFD------SSGFESMSPIKETVSSRQK 947
+L + ++ + +TS +K RR I D + S+S ++ ++ +
Sbjct: 1016 SELADADKASVASEVSTTSSTSKPPTGRRNISRIDLLAQPRRTRLGSLSARSDSEATISR 1075
Query: 948 PQMAPPVSDPENSQGPAAGSSDEPGKRRKSFCISTLANTKATSQFKGYRRRSSL 1001
+ ++ G SD+ R ++ IS L+++K S + S+L
Sbjct: 1076 SSASSRTAEAIIRSGARLVPSDKFSPRIRANSISRLSDSKVKSMTSAHGSASAL 1129
>gi|109255230 centrosomal protein 170kDa isoform beta [Homo sapiens]
Length = 1486
Score = 38.9 bits (89), Expect = 0.025
Identities = 99/463 (21%), Positives = 168/463 (36%), Gaps = 83/463 (17%)
Query: 554 KKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLS-PIPELPEVPEMTPSIPSIRRL 612
K ++LKS + KG KK KSL + +KP + PI +P + + T S PS L
Sbjct: 713 KAEEILKS-QTPKGGDKKESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSSLAL 771
Query: 613 GSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNA 672
+S ++ E R + L DPD M D +++++ N
Sbjct: 772 -----TSASRIRE---------RSESL--DPDSSMDTTLILKDTEAVMAFLEAKLREDNK 815
Query: 673 TSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEERVASDSPKPALT 732
T DE P+T P + E T S +S + ER ++ K +
Sbjct: 816 T-DEGPDT-----------PSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTS 863
Query: 733 LQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCNRLMPNSQKDCHC 792
L + + C S D+ K GA E K++ ++
Sbjct: 864 LYKDR------------CSTGSPSKDVT-----KSSSSGARE-KMEKKTKSRSTDVGSRA 905
Query: 793 LGDVLIENTKESKSQSEDLGRKPMESS---SVVSCRDRKDRRRSMCYSDGRSLHLEKNGN 849
G ++++ + S DL SS S +S D+ C GR
Sbjct: 906 DGRKFVQSSGRIRQPSVDLTDDDQTSSVPHSAISDIMSSDQETYSCKPHGR--------- 956
Query: 850 HTPSSSVGSSVEISLENSELFKDLSDAI-------EQTFQR-RNSETKVRRSTRL----Q 897
TP +S V LE S++ K + + T R R + T + R RL
Sbjct: 957 -TPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPRPTRTSLLRRARLGEASD 1015
Query: 898 KDLENEGLVWISLPLPSTSQKAK----RRTICTFD------SSGFESMSPIKETVSSRQK 947
+L + ++ + +TS +K RR I D + S+S ++ ++ +
Sbjct: 1016 SELADADKASVASEVSTTSSTSKPPTGRRNISRIDLLAQPRRTRLGSLSARSDSEATISR 1075
Query: 948 PQMAPPVSDPENSQGPAAGSSDEPGKRRKSFCISTLANTKATS 990
+ ++ G SD+ R ++ IS L+++K S
Sbjct: 1076 SSASSRTAEAIIRSGARLVPSDKFSPRIRANSISRLSDSKVKS 1118
>gi|109255228 centrosomal protein 170kDa isoform alpha [Homo sapiens]
Length = 1584
Score = 38.9 bits (89), Expect = 0.025
Identities = 99/463 (21%), Positives = 168/463 (36%), Gaps = 83/463 (17%)
Query: 554 KKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLS-PIPELPEVPEMTPSIPSIRRL 612
K ++LKS + KG KK KSL + +KP + PI +P + + T S PS L
Sbjct: 811 KAEEILKS-QTPKGGDKKESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSSLAL 869
Query: 613 GSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNA 672
+S ++ E R + L DPD M D +++++ N
Sbjct: 870 -----TSASRIRE---------RSESL--DPDSSMDTTLILKDTEAVMAFLEAKLREDNK 913
Query: 673 TSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEERVASDSPKPALT 732
T DE P+T P + E T S +S + ER ++ K +
Sbjct: 914 T-DEGPDT-----------PSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTS 961
Query: 733 LQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCNRLMPNSQKDCHC 792
L + + C S D+ K GA E K++ ++
Sbjct: 962 LYKDR------------CSTGSPSKDVT-----KSSSSGARE-KMEKKTKSRSTDVGSRA 1003
Query: 793 LGDVLIENTKESKSQSEDLGRKPMESS---SVVSCRDRKDRRRSMCYSDGRSLHLEKNGN 849
G ++++ + S DL SS S +S D+ C GR
Sbjct: 1004 DGRKFVQSSGRIRQPSVDLTDDDQTSSVPHSAISDIMSSDQETYSCKPHGR--------- 1054
Query: 850 HTPSSSVGSSVEISLENSELFKDLSDAI-------EQTFQR-RNSETKVRRSTRL----Q 897
TP +S V LE S++ K + + T R R + T + R RL
Sbjct: 1055 -TPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPRPTRTSLLRRARLGEASD 1113
Query: 898 KDLENEGLVWISLPLPSTSQKAK----RRTICTFD------SSGFESMSPIKETVSSRQK 947
+L + ++ + +TS +K RR I D + S+S ++ ++ +
Sbjct: 1114 SELADADKASVASEVSTTSSTSKPPTGRRNISRIDLLAQPRRTRLGSLSARSDSEATISR 1173
Query: 948 PQMAPPVSDPENSQGPAAGSSDEPGKRRKSFCISTLANTKATS 990
+ ++ G SD+ R ++ IS L+++K S
Sbjct: 1174 SSASSRTAEAIIRSGARLVPSDKFSPRIRANSISRLSDSKVKS 1216
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 38.5 bits (88), Expect = 0.033
Identities = 58/279 (20%), Positives = 116/279 (41%), Gaps = 22/279 (7%)
Query: 436 QSPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISETLSGTDTF---SSSNNH 492
+SPV E P+ K ++ E + L V +P K E S D F + S
Sbjct: 737 KSPVKEEAKSPE---KAKSPEKAKTLDVKSPEAKTPAKE---EARSPADKFPEKAKSPVK 790
Query: 493 EKISSPKVGRITRTSNRRNQLVSVVE-ESVCNLLNTEVQPCKEK-KINRRKSQETKCTKR 550
E++ SP+ + + + + + E V + + E +P + K K +K++E K
Sbjct: 791 EEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAP-- 848
Query: 551 ALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVPEMTPSIPSIR 610
A PK + K +K++ K++ + + +++ A +KP S + E E +P+
Sbjct: 849 ATPKTEEK-KDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPE 907
Query: 611 RLGSGYFSSNGKLEEVKTPKNPVKRKDLLRHDP-DLHMHQGYDKYDVSEFCSYIKSSSSL 669
+ + K+ EVK P ++ ++ + +P D + + E K +
Sbjct: 908 K------EAPAKV-EVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEE 960
Query: 670 GNATSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGT 708
+E P T ++K + K +K ++E K+ +
Sbjct: 961 KAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSS 999
>gi|41055989 M-phase phosphoprotein 8 [Homo sapiens]
Length = 860
Score = 38.1 bits (87), Expect = 0.043
Identities = 64/340 (18%), Positives = 133/340 (39%), Gaps = 38/340 (11%)
Query: 549 KRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVPEMTPSIPS 608
K+ P+K++ + RK + K +K++ ++ + + + +L V TP
Sbjct: 331 KKKTPRKAEDTRENRKLENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQTPKGRR 390
Query: 609 IRRLGSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLH------------MHQGYDKYDV 656
+ G +S++ E+ +T +N K K RHD D + + + +D+
Sbjct: 391 LSGEERGLWSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRNAFDL 450
Query: 657 SEFCSYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCAS 716
+ K+ S N +E P + I+++K ++ E N + TD+ A+
Sbjct: 451 FKLTPEEKNDVSENNRKREEIP-LDFKTIDDHKTKENKQSLKERRN-TRDETDTWAYIAA 508
Query: 717 VTEERVASDSPKPALTLQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGK 776
++ V ++ Q E S G Q Q + DL ++ + +DF +GK
Sbjct: 509 EGDQEVLD-------SVCQADENSDGRQ------QILSLGMDLQLEWMKLEDFQKHLDGK 555
Query: 777 ----LQCNRLMPNSQKDCHCLGDVLIENTKESKSQSEDLGRKPMESSSVV---SCRDRKD 829
+ + N +D GD + + ++ +L ++ ++V + + D
Sbjct: 556 DENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLDQEDSSGMTLVMLAAAGGQDD 615
Query: 830 RRRSMCYSDGRSLHLEKNGN----HTPSSSVGSSVEISLE 865
R + + +KNG H + ++V I LE
Sbjct: 616 LLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLE 655
>gi|42518068 trans-golgi network protein 2 [Homo sapiens]
Length = 437
Score = 37.7 bits (86), Expect = 0.056
Identities = 73/362 (20%), Positives = 128/362 (35%), Gaps = 44/362 (12%)
Query: 692 PKAKNKSESENEPKAGTDSPVSCASVTEERVASDSPKPA---LTLQQGQEFSAGGQNAEN 748
P+ S S++ +A T S E + DS + Q+G +G +
Sbjct: 60 PQTPKDSPSKSSAEAQTPEDTPNKSGAEAKTQKDSSNKSGAEAKTQKGSTSKSGSEAQTT 119
Query: 749 LCQFFKISPDLNIKCERKDDFLGAAEGKLQCNRLMPN-------SQKDCHCLGDVLIENT 801
K P+L + D G + + Q PN +QKD + T
Sbjct: 120 KDSTSKSHPEL----QTPKDSTGKSGAEAQTPEDSPNRSGAEAKTQKDSPSKSGSEAQTT 175
Query: 802 KESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGRSLHLEKNGNHTPSSSVGSSVE 861
K+ ++S G+ P + SS D+ + + G K+G++ + ++
Sbjct: 176 KDVPNKSGADGQTPKDGSSKSGAEDQTPK--DVPNKSGAEKQTPKDGSNKSGAEEQGPID 233
Query: 862 ISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDLENEGLVWISLPLPSTSQKAKR 921
++ + D+ + + S S + +N+ LP T+Q A +
Sbjct: 234 GPSKSGAEEQTSKDSPNKVVPEQPSRKD--HSKPISNPSDNK-----ELPKADTNQLADK 286
Query: 922 RTICTF---DSSGFES--MSPIKETVSSRQKPQMAPPVSDPENSQGPAAGSSDEPGKRRK 976
+ SG E+ +SP +E V S + + P ++ GP GS + K +
Sbjct: 287 GKLSPHAFKTESGEETDLISPPQEEVKSSEPTEDVEPKEAEDDDTGPEEGSPPKEEKEKM 346
Query: 977 SFCISTLANTKATSQFKGYRR-----RSSLNGKGESS-----------LTALERIEHNGE 1020
S S+ S G + S NG ESS L A+ I H+ +
Sbjct: 347 SGSASSENREGTLSDSTGSEKDDLYPNGSGNGSAESSHFFAYLVTAAILVAVLYIAHHNK 406
Query: 1021 RK 1022
RK
Sbjct: 407 RK 408
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 37.4 bits (85), Expect = 0.073
Identities = 48/220 (21%), Positives = 84/220 (38%), Gaps = 30/220 (13%)
Query: 369 KEKEAEDEENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTPVCKKDFSG 428
+E EA++E+ E + K + V + PE +P + KG +PV K
Sbjct: 578 EEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 637
Query: 429 LSSLLLEQSPVPE----PLPQPDFDDKGENLENIEPLQ--VSFAVLSSPNKSSISETLSG 482
+ +SPV E P+P+ ++KG++ + P++ V SP + + S+ G
Sbjct: 638 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVG 697
Query: 483 TDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRRKS 542
E +PK EE V E + K K + +K
Sbjct: 698 KGEQKEEEEKEVKEAPK------------------EEKV------EKKEEKPKDVPEKKK 733
Query: 543 QETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERD 582
E+ + A+ + + KS + K K K L E++
Sbjct: 734 AESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKE 773
Score = 34.3 bits (77), Expect = 0.62
Identities = 65/270 (24%), Positives = 98/270 (36%), Gaps = 59/270 (21%)
Query: 528 EVQPCKEKKINRRKSQETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKK 587
E KE+K KS+E TK L ++V +K K K V KS E+
Sbjct: 578 EEAEAKEEKKVEEKSEEV-ATKEELVADAKV-----EKPEKAKSPVPKSPVEEKG----- 626
Query: 588 PLLSPIPELPEVPEMTPSIPS--IRRLGSGYFSSNGKLEEVKTP--KNPVKRKDLLRHDP 643
SP+P+ P + +P + G + E+ K+P K+PV+ K
Sbjct: 627 --KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEK------- 677
Query: 644 DLHMHQGYDKYDVSEFCSYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESENE 703
K V E KS + +G E+ + K PK + + E +
Sbjct: 678 ---AKSPVPKSPVEE----AKSKAEVGKGEQKEEEEKEV------KEAPKEEKVEKKEEK 724
Query: 704 PKAGTDSPVSCASVTEERVA--------------SDSPKPALTLQQGQE-FSAGGQNAEN 748
PK + + + V EE VA ++ + LQQ +E AGG+
Sbjct: 725 PKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSE 784
Query: 749 LCQFFKISPDLNIKCERKDDFL--GAAEGK 776
+ D K RK+D G EGK
Sbjct: 785 -----EEGSDKGAKGSRKEDIAVNGEVEGK 809
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 37.4 bits (85), Expect = 0.073
Identities = 48/220 (21%), Positives = 84/220 (38%), Gaps = 30/220 (13%)
Query: 369 KEKEAEDEENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTPVCKKDFSG 428
+E EA++E+ E + K + V + PE +P + KG +PV K
Sbjct: 202 EEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 261
Query: 429 LSSLLLEQSPVPE----PLPQPDFDDKGENLENIEPLQ--VSFAVLSSPNKSSISETLSG 482
+ +SPV E P+P+ ++KG++ + P++ V SP + + S+ G
Sbjct: 262 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVG 321
Query: 483 TDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRRKS 542
E +PK EE V E + K K + +K
Sbjct: 322 KGEQKEEEEKEVKEAPK------------------EEKV------EKKEEKPKDVPEKKK 357
Query: 543 QETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERD 582
E+ + A+ + + KS + K K K L E++
Sbjct: 358 AESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKE 397
Score = 34.3 bits (77), Expect = 0.62
Identities = 65/270 (24%), Positives = 98/270 (36%), Gaps = 59/270 (21%)
Query: 528 EVQPCKEKKINRRKSQETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKK 587
E KE+K KS+E TK L ++V +K K K V KS E+
Sbjct: 202 EEAEAKEEKKVEEKSEEV-ATKEELVADAKV-----EKPEKAKSPVPKSPVEEKG----- 250
Query: 588 PLLSPIPELPEVPEMTPSIPS--IRRLGSGYFSSNGKLEEVKTP--KNPVKRKDLLRHDP 643
SP+P+ P + +P + G + E+ K+P K+PV+ K
Sbjct: 251 --KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEK------- 301
Query: 644 DLHMHQGYDKYDVSEFCSYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESENE 703
K V E KS + +G E+ + K PK + + E +
Sbjct: 302 ---AKSPVPKSPVEE----AKSKAEVGKGEQKEEEEKEV------KEAPKEEKVEKKEEK 348
Query: 704 PKAGTDSPVSCASVTEERVA--------------SDSPKPALTLQQGQE-FSAGGQNAEN 748
PK + + + V EE VA ++ + LQQ +E AGG+
Sbjct: 349 PKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSE 408
Query: 749 LCQFFKISPDLNIKCERKDDFL--GAAEGK 776
+ D K RK+D G EGK
Sbjct: 409 -----EEGSDKGAKGSRKEDIAVNGEVEGK 433
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 37.0 bits (84), Expect = 0.095
Identities = 63/271 (23%), Positives = 98/271 (36%), Gaps = 63/271 (23%)
Query: 369 KEKEAEDEENFEAPAFLNMRKRKRVTFG---------------EDLSPEVFDESLPANT- 412
K ++ E+ E F P L ++ R G +D +P V DE + A +
Sbjct: 904 KRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATP-VRDEPMDAESI 962
Query: 413 ---------------PLRKGGTPVCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLEN 457
P KG K D S +S E P PQ D + E
Sbjct: 963 TFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKK--ENIVKPAKGPQEKVDGERERSPR 1020
Query: 458 IEPLQVSFAVLSSPNKSSISETLSGTDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVV 517
EP P K + ET +T SSS SS K +IT T + + +
Sbjct: 1021 SEP----------PIKKAKEETPKTDNTKSSS------SSQKDEKITGTPRKAHSKSAKE 1064
Query: 518 EESVCNLLNTEVQPCKEKKINRRKSQETK----CTKRALPKKSQVLKSCRKKKGKGKKSV 573
+ E +P KE+K+ + S++ K TK KK KG+ +K
Sbjct: 1065 HQ--------ETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRK 1116
Query: 574 QKSLYGERDIASKKPLLSPIPELPEVPEMTP 604
+ ++D S +S + E+ E+ + +P
Sbjct: 1117 TEEKGVDKDFESSSMKISKL-EVTEIVKPSP 1146
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 37.0 bits (84), Expect = 0.095
Identities = 63/271 (23%), Positives = 98/271 (36%), Gaps = 63/271 (23%)
Query: 369 KEKEAEDEENFEAPAFLNMRKRKRVTFG---------------EDLSPEVFDESLPANT- 412
K ++ E+ E F P L ++ R G +D +P V DE + A +
Sbjct: 938 KRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATP-VRDEPMDAESI 996
Query: 413 ---------------PLRKGGTPVCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLEN 457
P KG K D S +S E P PQ D + E
Sbjct: 997 TFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKK--ENIVKPAKGPQEKVDGERERSPR 1054
Query: 458 IEPLQVSFAVLSSPNKSSISETLSGTDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVV 517
EP P K + ET +T SSS SS K +IT T + + +
Sbjct: 1055 SEP----------PIKKAKEETPKTDNTKSSS------SSQKDEKITGTPRKAHSKSAKE 1098
Query: 518 EESVCNLLNTEVQPCKEKKINRRKSQETK----CTKRALPKKSQVLKSCRKKKGKGKKSV 573
+ E +P KE+K+ + S++ K TK KK KG+ +K
Sbjct: 1099 HQ--------ETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRK 1150
Query: 574 QKSLYGERDIASKKPLLSPIPELPEVPEMTP 604
+ ++D S +S + E+ E+ + +P
Sbjct: 1151 TEEKGVDKDFESSSMKISKL-EVTEIVKPSP 1180
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 37.0 bits (84), Expect = 0.095
Identities = 51/221 (23%), Positives = 86/221 (38%), Gaps = 10/221 (4%)
Query: 810 DLGRKP-----MESSSVVSCRDRKDRRRSMCYSDGRSLHLEKNGNHTPSSSVGSSVEISL 864
D+G P + S++ + + K+RR S S S + + + SSS GSS S
Sbjct: 2505 DVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDS- 2563
Query: 865 ENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDLENEGLVWISLPLPSTSQKAKRRTI 924
E S L A+++ + + R R + + S S+S + +
Sbjct: 2564 EGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSS 2623
Query: 925 CTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENSQGPAAGSSDEPGKRRKSF---CIS 981
+ SS S S + SS +P P+ PA+ PG+RR I
Sbjct: 2624 SSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPID 2683
Query: 982 TLANTKATSQFKGYRRRSSLN-GKGESSLTALERIEHNGER 1021
+L ++++ S RRR S + ++ ER G+R
Sbjct: 2684 SLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQR 2724
>gi|38327039 heat shock 70kDa protein 4 [Homo sapiens]
Length = 840
Score = 36.6 bits (83), Expect = 0.12
Identities = 38/147 (25%), Positives = 66/147 (44%), Gaps = 41/147 (27%)
Query: 855 SVGSSVEISLENSE----LFKDLSDAIEQ------TFQRRNSE---------TKVRRSTR 895
++G ++I + SE LF++L I+Q +F+ + + TKV +ST
Sbjct: 680 NLGQPIKIRFQESEERPKLFEELGKQIQQYMKIISSFKNKEDQYDHLDAADMTKVEKST- 738
Query: 896 LQKDLENEGLVWISLPLPSTSQKAKRRTICTFDS--SGFESMSPIKETVS------SRQK 947
NE + W++ L ++++ T D E + IKE S S+ K
Sbjct: 739 ------NEAMEWMNNKLNLQNKQS-----LTMDPVVKSKEIEAKIKELTSTCSPIISKPK 787
Query: 948 PQMAPPVSDPENSQ--GPAAGSSDEPG 972
P++ PP + +N++ GP G D PG
Sbjct: 788 PKVEPPKEEQKNAEQNGPVDGQGDNPG 814
>gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]
Length = 2089
Score = 36.6 bits (83), Expect = 0.12
Identities = 63/331 (19%), Positives = 120/331 (36%), Gaps = 57/331 (17%)
Query: 437 SPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISE----TLSGTDTFSSSNNH 492
+P P P+ + + P S A S N+SS+ + + S++
Sbjct: 1116 TPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTD 1175
Query: 493 EKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEV----------QPCKEKKINRRKS 542
+ ++S ++TR R+ V E V L + +P + R+
Sbjct: 1176 QPVTSEPTSQVTRGRKSRSS-VKTPETVVPTALELQPSTSTDRPVTSEPTSQATRGRKNR 1234
Query: 543 QETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVPEM 602
K + +P ++ S + + ++ G ++ +S K +P P +P PE+
Sbjct: 1235 SSVKTPEPVVPTAPELQPSTSTDQPVTSEPTYQATRGRKNRSSVK---TPEPVVPTAPEL 1291
Query: 603 TPSI----PSIRRLGSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSE 658
PS P + S S + VKTP+ V P+L + D+ +
Sbjct: 1292 RPSTSTDRPVTPKPTSRTTRSRTNMSSVKTPETVVPTA------PELQISTSTDQPVTPK 1345
Query: 659 FCSYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVT 718
S +++ S N +S ++P + +P A E P T+ PV
Sbjct: 1346 PTS--RTTRSRTNMSSVKNPES---------TVPIA-----PELPPSTSTEQPV------ 1383
Query: 719 EERVASDSPKPALTLQQGQEFSAGGQNAENL 749
+P+P +G++ + G+ E L
Sbjct: 1384 -------TPEPTSRATRGRKNRSSGKTPETL 1407
>gi|24432077 melanoma associated antigen (mutated) 1-like 1 [Homo
sapiens]
Length = 637
Score = 36.6 bits (83), Expect = 0.12
Identities = 38/160 (23%), Positives = 73/160 (45%), Gaps = 17/160 (10%)
Query: 224 LQIFNIDTD-RACAVETSVDLSEISSKLGSTQSGFLVEESLPLSELTETSNALKVADCVV 282
+QI ++D + + ET + L++ + + G E+S P +E T +LKVA ++
Sbjct: 39 VQILSLDEKIKLDSTETKI-LNKSQIEAIAASLGLQSEDSAPPTEETAYGRSLKVALGIL 97
Query: 283 GKGS--SDAVSPDTFTAEVSSDAVPDVRSPATPACRR-----DLPTPKTFVLRSVLKKPS 335
+ + S A + D + S VP +S + P + DLP L++
Sbjct: 98 NERTNLSQASTSDEEEITMLSQNVPQKQSDSPPHKKYRKDEGDLP--------GCLEERE 149
Query: 336 VKMCLESLQEHCNNLYDDDGTHPSLISNLPNCCKEKEAED 375
CL + E ++LYDD P+++ +P+ + K ++
Sbjct: 150 NSACLLASSESDDSLYDDKSQAPTMVDTIPSEVETKSLQN 189
>gi|167234419 thyroid hormone receptor associated protein 3 [Homo
sapiens]
Length = 955
Score = 36.6 bits (83), Expect = 0.12
Identities = 58/306 (18%), Positives = 113/306 (36%), Gaps = 33/306 (10%)
Query: 469 SSPNKSSISETLSGTDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTE 528
S + S S+ + + SS+NH ++ S K R S + + S + +
Sbjct: 143 SRNSDKSSSDRSRRSSSSRSSSNHSRVESSK-----RKSAKEKKSSSKDSRPSQAAGDNQ 197
Query: 529 VQPCKEKKINRRKSQETKCTKRALP------------KKSQVLKSCRKKKGKGKKSVQKS 576
KE+ + SQ+TK ++ + P + S V + +++ KS +S
Sbjct: 198 GDEAKEQTFSGGTSQDTKASESSKPWPDATYGTGSASRASAVSELSPRERSPALKSPLQS 257
Query: 577 LYGERDIASKKPLLSPIPELPEVPEMTPSIPSIRRLGSGYFSS--NGKLEEVKTPKNPVK 634
+ R P+ P P L +M ++PS G+GY S G+ + +P K
Sbjct: 258 VVVRRRSPRPSPVPKPSPPLSSTSQMGSTLPS----GAGYQSGTHQGQFDHGSGSLSPSK 313
Query: 635 RKDLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNATSDEDPNTNIMNINENKNIPKA 694
+ + + P G + + +S++S G A + ++K +
Sbjct: 314 KSPVGKSPPSTGSTYGSSQKE--------ESAASGGAAYTKRYLEEQKTENGKDKEQKQT 365
Query: 695 KNKSESENEPKAGTDSPVSCASVTEERVA--SDSPKPALTLQQGQEFSAGGQNAENLCQF 752
E E + +D+ + + + A +DS KP Q + + + + F
Sbjct: 366 NTDKEKIKEKGSFSDTGLGDGKMKSDSFAPKTDSEKPFRGSQSPKRYKLRDDFEKKMADF 425
Query: 753 FKISPD 758
K D
Sbjct: 426 HKEEMD 431
>gi|95147342 chromodomain helicase DNA binding protein 9 [Homo
sapiens]
Length = 2881
Score = 36.2 bits (82), Expect = 0.16
Identities = 67/271 (24%), Positives = 102/271 (37%), Gaps = 42/271 (15%)
Query: 630 KNPVKRKDL-LRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGN--ATSDEDPNTNIMNIN 686
K+ V R D + DP+L Y S+ S+ L P T++ +
Sbjct: 1976 KHGVSRTDYHILRDPELSFMAAQRNYSQSKMAHSRTSTPLLQQYQVALSASPLTSLPRLL 2035
Query: 687 ENKNIPKAKNKSESEN---EPKAGTDSPVSCASVTEERVASD--SPKPALTLQQGQEFSA 741
+ K I + K +SEN EP++ + +S T + S+ SPK + Q + +
Sbjct: 2036 DAKGIILEEMKVKSENLKEEPQSSEEESMSSVE-TRTLIKSEPVSPKNGVLPQATGDQKS 2094
Query: 742 GGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCNRLMPNSQKD-CHCLGDVLIEN 800
GG KCE + A L N P S+K H G E+
Sbjct: 2095 GG------------------KCETDRRMVAARTEPLTPN---PASKKPRVHKRGS---ES 2130
Query: 801 TKESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGRSLHLEKNGNHTPSSSVGSSV 860
+ +S S SE SSS S S +S S + + SSS SS
Sbjct: 2131 SSDSDSDSERSSCSSRSSSSSSSS--------SCSHSRSGSSSSSSSSCSSASSSSSSST 2182
Query: 861 EISLENSELFKDLSDAIEQTFQRRNSETKVR 891
S +S + SD+ E+ Q+R S T ++
Sbjct: 2183 SSSSSSSSSSSEESDSDEEEAQKRESTTHMK 2213
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 35.8 bits (81), Expect = 0.21
Identities = 30/136 (22%), Positives = 51/136 (37%), Gaps = 20/136 (14%)
Query: 638 LLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNATSDEDP----------------NTN 681
L + P LH+ G ++ ++ EF +K+ L + P
Sbjct: 159 LAGNGPVLHLELGQEEAELEEFLCPVKTPPGLVGVAAALQPFPALQNISLKHLGTEIQNT 218
Query: 682 IMNINENKNIPKAKNKSESENEPKAG----TDSPVSCASVTEERVASDSPKPALTLQQGQ 737
+ NI NK ++ E+ P++G + P++ + T R DSPKPA
Sbjct: 219 MHNIRGNKQAQGTGHEPPGEDSPQSGEPQREEQPLASDASTPGREPEDSPKPAPKPSLTI 278
Query: 738 EFSAGGQNAENLCQFF 753
F+ + N FF
Sbjct: 279 SFAQKAKRQNNTFPFF 294
>gi|20070205 ladinin 1 [Homo sapiens]
Length = 517
Score = 35.8 bits (81), Expect = 0.21
Identities = 79/351 (22%), Positives = 134/351 (38%), Gaps = 48/351 (13%)
Query: 421 VCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISETL 480
V +KD+S LSSL +++ E + + + NL + + + ++S SE L
Sbjct: 3 VSRKDWSALSSLARQRTLEDEEEQERERRRRHRNLSSTTDDEAPRLSQNGDRQASASERL 62
Query: 481 SGTDTF--------SSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPC 532
+ +S + E I S I RT R Q VVE + +Q
Sbjct: 63 PSVEEAEVPKPLPPASKDEDEDIQS-----ILRTRQERRQRRQVVEAA-----QAPIQER 112
Query: 533 KEKKINRRKSQETKCTKRALPKKSQVLKSCRKKKGKGKKS----VQKSLYGERDIASKK- 587
E + R + T++ L K ++ R++ + ++ ++SL G KK
Sbjct: 113 LEAEEGRNSLSPVQATQKPLVSKKELEIPPRRRLSREQRGPWALEEESLVGREPEERKKG 172
Query: 588 -PLLSPIPELPEVPEMTPSIPSI---------RRLGSGYFSSNGKLEEVKTPKNPVKRKD 637
P SP+ E +P+ T S+ + L S S + K+ V +N ++K
Sbjct: 173 VPEKSPVLEKSSMPKKTAPEKSLVSDKTSISEKVLASEKTSLSEKI-AVSEKRNSSEKKS 231
Query: 638 LLRHDPDLH------MHQGYDKYDVSEFCS-YIKSSSSLGNATSDEDPNTNIMNINEN-- 688
+L M G + VSE S + K+ +S + T+D P +E
Sbjct: 232 VLEKTSVSEKSLAPGMALGSGRRLVSEKASIFEKALASEKSPTADAKPAPKRATASEQPL 291
Query: 689 KNIPKAKNKSESENEPKAGTDSPVSCASVTEERVASDSPK-----PALTLQ 734
P A S + + + G P ++ ASD P P +TLQ
Sbjct: 292 AQEPPASGGSPATTKEQRGRALPGKNLPSLAKQGASDPPTVASRLPPVTLQ 342
>gi|160707950 methyl CpG binding protein 2 isoform 2 [Homo sapiens]
Length = 498
Score = 35.4 bits (80), Expect = 0.28
Identities = 40/148 (27%), Positives = 52/148 (35%), Gaps = 30/148 (20%)
Query: 517 VEESVCNLLNTEVQPCKEKKINRRKSQETKCTKRAL------PKKSQVLKSCRKKKGKGK 570
V+ES + V P K++K S E K + L K + LK+C+ K K
Sbjct: 300 VKESSIRSVQETVLPIKKRKTRETVSIEVKEVVKPLLVSTLGEKSGKGLKTCKSPGRKSK 359
Query: 571 KSVQKSLYGERDIASKK----------------PLLSPIPELPEVPEMT---PSIPSIRR 611
+S K KK PLL P+P P PE + S P +
Sbjct: 360 ESSPKGRSSSASSPPKKEHHHHHHHSESPKAPVPLLPPLPPPPPEPESSEDPTSPPEPQD 419
Query: 612 LGSGY-----FSSNGKLEEVKTPKNPVK 634
L S G LE PK P K
Sbjct: 420 LSSSVCKEEKMPRGGSLESDGCPKEPAK 447
>gi|4826830 methyl CpG binding protein 2 isoform 1 [Homo sapiens]
Length = 486
Score = 35.4 bits (80), Expect = 0.28
Identities = 40/148 (27%), Positives = 52/148 (35%), Gaps = 30/148 (20%)
Query: 517 VEESVCNLLNTEVQPCKEKKINRRKSQETKCTKRAL------PKKSQVLKSCRKKKGKGK 570
V+ES + V P K++K S E K + L K + LK+C+ K K
Sbjct: 288 VKESSIRSVQETVLPIKKRKTRETVSIEVKEVVKPLLVSTLGEKSGKGLKTCKSPGRKSK 347
Query: 571 KSVQKSLYGERDIASKK----------------PLLSPIPELPEVPEMT---PSIPSIRR 611
+S K KK PLL P+P P PE + S P +
Sbjct: 348 ESSPKGRSSSASSPPKKEHHHHHHHSESPKAPVPLLPPLPPPPPEPESSEDPTSPPEPQD 407
Query: 612 LGSGY-----FSSNGKLEEVKTPKNPVK 634
L S G LE PK P K
Sbjct: 408 LSSSVCKEEKMPRGGSLESDGCPKEPAK 435
>gi|117553580 adaptor-related protein complex 3, delta 1 subunit
isoform 2 [Homo sapiens]
Length = 1153
Score = 35.0 bits (79), Expect = 0.36
Identities = 86/416 (20%), Positives = 159/416 (38%), Gaps = 38/416 (9%)
Query: 214 LTDAEGKVIGLQIFNIDTDRACAVETSVDLSEISSKLGSTQSGFLVEESLPLSELTETSN 273
+T G + + + N+ A ++ E TQ L+ + LP +
Sbjct: 511 VTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQ---LMVDRLPQFVQSADLE 567
Query: 274 ALKVADCVVG--KGSSDAVSPDTFTAEVSSDAVPDVRSPATPACRRDLPTPKTFVLRSVL 331
+ A C++ K + D AE S +P P ++ +P P+ L + +
Sbjct: 568 VQERASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWI 627
Query: 332 KKPSVKMCLESLQEHCNNLYDDDGT----HPSLISNLPNCCKEKEAEDEENFEAPAFLNM 387
+P ES E ++ ++ H ++ + +EA +E P ++
Sbjct: 628 NEPLSDS--ESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKS 685
Query: 388 ----RKRKRVTFGEDLSPEV-FDESLPANTPLRKGGTPVCKKDFSGLSSLLLEQSPVPEP 442
+KR + T G + P V D S+P P K + LE+ +
Sbjct: 686 SPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKK 745
Query: 443 LPQPDFDDKG-------ENLENIEPLQ-VSFAVLSSPNKS--SISETLSGTDTFSSSN-- 490
+ + K E+ E+I P Q V P + S + D + + +
Sbjct: 746 RKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDID 805
Query: 491 ------NHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRRKSQE 544
+ EK+ K R T TS + V +VE+ E + KEK+ ++ K +E
Sbjct: 806 LDKPLADSEKLPIQK-HRNTETSKSPEKDVPMVEKKSKKPKKKEKKH-KEKERDKEKKKE 863
Query: 545 TKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVP 600
+ K PKK + K ++++ KGKK +K G + A+ +P+ + PE ++P
Sbjct: 864 KEKKKSPKPKKKKHRKE-KEERTKGKKKSKKQPPGSEE-AAGEPVQNGAPEEEQLP 917
>gi|148806891 hypothetical protein LOC54906 [Homo sapiens]
Length = 2430
Score = 34.7 bits (78), Expect = 0.47
Identities = 60/273 (21%), Positives = 106/273 (38%), Gaps = 35/273 (12%)
Query: 636 KDLLRHDPDLH--MHQGYDKYDVSEFCSYIKSSSSLGNATSDEDPNTNIMNINENKNIPK 693
+DL++H ++ H ++ D + C+ I T +++ + I N +
Sbjct: 1018 QDLIQHGSPINNECHPSLERKDDNMGCAVINPEPI--TLTFEKNAHVPIQTEGVNTADER 1075
Query: 694 AKNKSE--SENEPKAGTDSPVSCASVTEERVASDSPKPALTLQQGQEF----SAGGQNAE 747
K E + P A PVS + + D P + Q+G ++ S GG+ +
Sbjct: 1076 TTFKKELIKQVSPAASLRHPVSTSENARTQGLRDIPSLVVAGQKGTKYLCASSVGGETLD 1135
Query: 748 N-LCQFFKISPDLNIKCERKDDFLGAAEGKLQCNRLMPNSQKDCHCLGDVLIENTKESKS 806
+C K +P K + A + L P+ ++ C D L +
Sbjct: 1136 KAVCSLQKETPLPVSLPSDKTMVMEALSLAKSSSHLSPS--EEVRCTQDFLSQTQSLLGL 1193
Query: 807 QSE---DLGRKPMESSSVVSCRDRKDRRR---SMCYSDGRSLHLEKNGNHTPS------- 853
SE +L + ++SSS + R+ S C++ G SL L KN + P+
Sbjct: 1194 SSEGLLELTQVEVDSSSASTTLGRQCSLNCISSGCHTSGDSLELRKNHKNGPNTENMNLE 1253
Query: 854 ---------SSVGSSVEISLENSELFKDLSDAI 877
+S+ S E+SLE SE D+ A+
Sbjct: 1254 AFDSVFIKQTSLSVSREVSLELSEEDSDIDLAL 1286
>gi|187608809 hypothetical protein LOC23240 isoform 2 [Homo sapiens]
Length = 1609
Score = 34.3 bits (77), Expect = 0.62
Identities = 29/117 (24%), Positives = 54/117 (46%), Gaps = 5/117 (4%)
Query: 491 NHEKISSPKVGRITRTSNRRNQLVSVVEE-SVC-NLLNTEVQPCKEKKINRRKSQETKCT 548
N + P + I+R +N NQ V V E C NL + +P EKKI++ ++
Sbjct: 1121 NSPQYHQPDLPEISRKNNGNNQQVPVKNEVDHCENLKKVDTKPSSEKKIHKTSREDMFSE 1180
Query: 549 KRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIA---SKKPLLSPIPELPEVPEM 602
K+ +P Q +KK + ++ ++L + +KK ++P+ PE ++
Sbjct: 1181 KQDIPFVEQEDPYRKKKLQEKREGNLQNLNWSKSRTCRKNKKRGVAPVSRPPEQSDL 1237
>gi|196114949 hypothetical protein LOC23240 isoform 1 [Homo sapiens]
Length = 1610
Score = 34.3 bits (77), Expect = 0.62
Identities = 29/117 (24%), Positives = 54/117 (46%), Gaps = 5/117 (4%)
Query: 491 NHEKISSPKVGRITRTSNRRNQLVSVVEE-SVC-NLLNTEVQPCKEKKINRRKSQETKCT 548
N + P + I+R +N NQ V V E C NL + +P EKKI++ ++
Sbjct: 1122 NSPQYHQPDLPEISRKNNGNNQQVPVKNEVDHCENLKKVDTKPSSEKKIHKTSREDMFSE 1181
Query: 549 KRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIA---SKKPLLSPIPELPEVPEM 602
K+ +P Q +KK + ++ ++L + +KK ++P+ PE ++
Sbjct: 1182 KQDIPFVEQEDPYRKKKLQEKREGNLQNLNWSKSRTCRKNKKRGVAPVSRPPEQSDL 1238
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.126 0.354
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,741,538
Number of Sequences: 37866
Number of extensions: 2123304
Number of successful extensions: 7008
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 113
Number of HSP's that attempted gapping in prelim test: 6859
Number of HSP's gapped (non-prelim): 312
length of query: 1023
length of database: 18,247,518
effective HSP length: 112
effective length of query: 911
effective length of database: 14,006,526
effective search space: 12759945186
effective search space used: 12759945186
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.