Search of human proteins with 42542386

Search of human proteins with 42542386

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|42542386 solute carrier family 22 (organic anion/cation
transporter), member 9 [Homo sapiens]
         (553 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|42542386 solute carrier family 22 (organic anion/cation trans...  1113   0.0  
gi|153791484 putative UST1-like organic anion transporter [Homo ...   790   0.0  
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]       632   0.0  
gi|211059435 solute carrier family 22, member 24 [Homo sapiens]       620   e-177
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]          454   e-128
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]          424   e-118
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...   361   e-100
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]          360   1e-99
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...   358   5e-99
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]       343   2e-94
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...   317   2e-86
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...   314   1e-85
gi|166064021 solute carrier family 22 (organic anion transporter...   263   4e-70
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...   258   1e-68
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...   253   4e-67
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]          223   5e-58
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]           187   2e-47
gi|169202895 PREDICTED: similar to solute carrier family 22, mem...   187   3e-47
gi|239750073 PREDICTED: similar to solute carrier family 22, mem...   187   3e-47
gi|239744382 PREDICTED: hypothetical protein XP_002343132 [Homo ...   187   3e-47
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]           177   2e-44
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]        168   1e-41
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]          165   9e-41
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...   161   2e-39
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]          158   1e-38
gi|157426885 organic cation transporter like 4 [Homo sapiens]         154   3e-37
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]       144   2e-34
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...   133   5e-31
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ...   120   4e-27
gi|170650643 solute carrier family 22, member 23 isoform a [Homo...   119   6e-27

>gi|42542386 solute carrier family 22 (organic anion/cation
           transporter), member 9 [Homo sapiens]
          Length = 553

 Score = 1113 bits (2879), Expect = 0.0
 Identities = 553/553 (100%), Positives = 553/553 (100%)

Query: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
           MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS
Sbjct: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60

Query: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120
           DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW
Sbjct: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120

Query: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180
           VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY
Sbjct: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180

Query: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCP 240
           LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCP
Sbjct: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCP 240

Query: 241 SGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELR 300
           SGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELR
Sbjct: 241 SGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELR 300

Query: 301 KAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFA 360
           KAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFA
Sbjct: 301 KAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFA 360

Query: 361 NFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAIC 420
           NFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAIC
Sbjct: 361 NFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAIC 420

Query: 421 LLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIA 480
           LLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIA
Sbjct: 421 LLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIA 480

Query: 481 GALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPRE 540
           GALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPRE
Sbjct: 481 GALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPRE 540

Query: 541 PKQEDPRVEVTQF 553
           PKQEDPRVEVTQF
Sbjct: 541 PKQEDPRVEVTQF 553


>gi|153791484 putative UST1-like organic anion transporter [Homo
           sapiens]
          Length = 547

 Score =  790 bits (2041), Expect = 0.0
 Identities = 394/534 (73%), Positives = 441/534 (82%), Gaps = 1/534 (0%)

Query: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
           MAFQDLL   G L RFQILQ VFL +F V  Y    LENF AFI  HRCWVHILDNDT+ 
Sbjct: 1   MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60

Query: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120
           DND G LSQDALLRISIP DSN+RPEKCRRFVHPQW+L+HLNGTFPNTS+ D EPCVDGW
Sbjct: 61  DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120

Query: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180
           VYD+ SF STIVT+WDLVC+SQ L SVAKF+FMAGMMVGG L GHLSDRFGR+FVLRW Y
Sbjct: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180

Query: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCP 240
           LQ+AIVGTCAA APT L+YCSLRFL+G A  S+I NT++LI EW TH+F AM +TL +C 
Sbjct: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240

Query: 241 SGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELR 300
           + I  +TL  LAF IRD  ILQLV+S P FV FL S WL ESARWLIINNKPEEGLKELR
Sbjct: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300

Query: 301 KAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFA 360
           KAAHR+GMKNA D LT+E+LKSTMK+ELEAAQKK  SLCE+L +PNICKRI  LSF RFA
Sbjct: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKH-SLCELLRIPNICKRICFLSFVRFA 359

Query: 361 NFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAIC 420
           + + ++GL LH+QHLGNNVFLLQTLFGAV LLANCVAPWAL +M+RR SQMLLMFLLA C
Sbjct: 360 STIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATC 419

Query: 421 LLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIA 480
           LLAIIFVPQEMQTLR VLATLG+GA++L  T + A  NE+IP+IIR RA GI   FANI 
Sbjct: 420 LLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIG 479

Query: 481 GALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNE 534
           GALA LMMILS+YS PLPWIIYGVF  +SG   LLLPETRN+PL D+IQD +NE
Sbjct: 480 GALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENE 533


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score =  632 bits (1631), Expect = 0.0
 Identities = 308/540 (57%), Positives = 400/540 (74%), Gaps = 1/540 (0%)

Query: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
           MAF++LL   G L RFQ+L  VF+    +    H +LENF A IPGHRCWVH+LDN+T S
Sbjct: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60

Query: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120
            N+TG LS+DALLRISIPLDSN+RPEKCRRFVHPQWQLLHLNGT  +TS+AD EPCVDGW
Sbjct: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120

Query: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180
           VYD+  F STIVT+WDLVCD QSL SV +F+ + GM+VGGI+GGH+SDRFGRRF+LRWC 
Sbjct: 121 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 180

Query: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCP 240
           LQ+AI  TCAA APTF +YC LRFL+G ++M +I+N  + I EW     +A+ + L    
Sbjct: 181 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 240

Query: 241 SGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELR 300
             I  + L GLA+  RDW  L +V SVP+FV FL S WL+ESARWLII NK +EGLK LR
Sbjct: 241 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 300

Query: 301 KAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFA 360
           K A  +G+KNA +TL +E+++STM++EL+AAQ  K ++C++   P++ KRI +L F RFA
Sbjct: 301 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQ-TKTTVCDLFRNPSMRKRICILVFLRFA 359

Query: 361 NFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAIC 420
           N + ++G  +++QH+G+N+FLLQ L+GAV L+  C+A   L +M RR SQ+L MFL+ + 
Sbjct: 360 NTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLS 419

Query: 421 LLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIA 480
           +LA  FVP+EMQTLR  LA LG+G SA   +    H  E+IPT++RARA GI+ T + I 
Sbjct: 420 ILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIG 479

Query: 481 GALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPRE 540
            ALAPL+M L+V+   LPWIIYG+FP I G    LLPET+N PL DTI+D +N++K+ +E
Sbjct: 480 AALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKNLKE 539


>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score =  620 bits (1598), Expect = e-177
 Identities = 312/553 (56%), Positives = 398/553 (71%), Gaps = 2/553 (0%)

Query: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
           M F  LL   G + RFQI    F  I  +  + + +LENFTAF P HRCWV +LDNDTVS
Sbjct: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60

Query: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120
           DNDTG LS+D LLRISIPLDSN+RP+KC+RF+HPQWQLLHLNGTFPNT++ D EPCVDGW
Sbjct: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120

Query: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180
           VYDR SF STIVTEWDLVC+SQSL S+ + +FMAG ++GG++ GHLSDR GR+ + + C+
Sbjct: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180

Query: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCP 240
           LQ+AI  TCAA APTFL+YC LRFL+G + M+++ NT +L  EW   R ++M I + +C 
Sbjct: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240

Query: 241 SGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELR 300
             +  M L GLAFAI+DWHILQL VS P  V+FL+S  ++ESARWLIINN+ +EGLKELR
Sbjct: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300

Query: 301 KAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFA 360
           + AH +G KN  +TLT E+++STMKKEL+A  + K S+  +   P +  R+  L F RFA
Sbjct: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAV-RIKTSIFSLFRAPKLRMRVFGLCFVRFA 359

Query: 361 NFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAIC 420
             + ++GL L++QHLG+NV L Q L GAV   A CV+   L +M RR SQ+L  F + + 
Sbjct: 360 ITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLF 419

Query: 421 LLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIA 480
           +L   F+PQEMQ LR VLATLG+G+ + A+  A  H NE++PTI+R+   GINA      
Sbjct: 420 ILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTG 479

Query: 481 GALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPRE 540
            ALAPL+M L  YSP LPWI YGVFP ++    LLLPETR+ PL +TIQD +NE KD R 
Sbjct: 480 AALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENE-KDSRN 538

Query: 541 PKQEDPRVEVTQF 553
            KQED  ++VTQF
Sbjct: 539 IKQEDTCMKVTQF 551


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score =  454 bits (1169), Expect = e-128
 Identities = 243/534 (45%), Positives = 326/534 (61%), Gaps = 1/534 (0%)

Query: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
           MAF +LL   G L RFQ+LQT+ L +  +      MLENF+A +P HRCW  +LDN T  
Sbjct: 1   MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60

Query: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120
            +  G+LS +ALL ISIP   N RP +CRRF  PQWQLL  N T  + S+AD EPCVDGW
Sbjct: 61  ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120

Query: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180
           VYDR  F+STIV +W+LVCDS +L  +A+ +++AG++VG    G  SDRFGRR VL W Y
Sbjct: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180

Query: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCP 240
           LQ+A++GT AA AP F +YC  RFL   A   ++ NT  L+ EW   R + + +TL    
Sbjct: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240

Query: 241 SGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELR 300
                   A +A+ +RDW +LQLVVSVP+F+ FL S WL ESARWL+   + + GL+EL 
Sbjct: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300

Query: 301 KAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFA 360
           + A  +G    +DTLT E+L S M++EL   Q    SL  +L MP +  R  + +   FA
Sbjct: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQ-PPASLGTLLRMPGLRFRTCISTLCWFA 359

Query: 361 NFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAIC 420
               +FGL L +Q LG+N+FLLQ   G V + A   A   L ++ RR +    + L  +C
Sbjct: 360 FGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLC 419

Query: 421 LLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIA 480
           +LA   VP EM  LR  LA LGLG    A T    + +E+ PT++R  A+G+    A   
Sbjct: 420 ILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGG 479

Query: 481 GALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNE 534
             L PL+ +L V+ P LP ++YG  P +SG A LLLPET++ PL DTIQD +N+
Sbjct: 480 AILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQ 533


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score =  424 bits (1089), Expect = e-118
 Identities = 237/554 (42%), Positives = 332/554 (59%), Gaps = 9/554 (1%)

Query: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDT-V 59
           MAF  LL  AG +  FQ LQ +   +  +      +LENF+A IPGHRCW H+LDN + V
Sbjct: 1   MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAV 60

Query: 60  SDNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDG 119
           S N    ++  ALL ISIP   N  P +CRRF  PQWQLL  N T  + S+AD EPCVDG
Sbjct: 61  STN----MTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDG 116

Query: 120 WVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWC 179
           WVYDR  F+STIV +WDLVC SQ L  +++ +FM+G++VG  + G LS RFGR+ +L WC
Sbjct: 117 WVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWC 176

Query: 180 YLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMC 239
            LQ+A+ GT    APTF+IYC LRF++      +  +++ L+ EW T   +A+ +T+  C
Sbjct: 177 CLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGC 236

Query: 240 PSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKEL 299
                   L GLAFA+RDW  LQL  SVP+F I L S WL ESARWLII  KP++ L+EL
Sbjct: 237 AFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQEL 296

Query: 300 RKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRF 359
           RK A  +G K A++ LT+E+L S++K+E+ A+ K+  S+ ++  +P +  R   +    F
Sbjct: 297 RKVARINGHKEAKN-LTIEVLMSSVKEEV-ASAKEPRSVLDLFCVPVLRWRSCAMLVVNF 354

Query: 360 ANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAI 419
           +  ++Y+GL   +Q LG ++FLLQ LFGAV  L        L ++ RR  Q     +  +
Sbjct: 355 SLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGL 414

Query: 420 CLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANI 479
            +LA + VPQ++QTLR V A LG G   ++ T    +  E+ PT +R  A GI  T   +
Sbjct: 415 AILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRL 474

Query: 480 AGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFL-LLPETRNKPLFDTIQDEKNERKDP 538
              + PL+++     P LP ++YGV    S    L  LPET+  PL DTIQD ++++   
Sbjct: 475 GAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQKSTA 534

Query: 539 RE-PKQEDPRVEVT 551
            +  +QE   VE T
Sbjct: 535 AQGNRQEAVTVEST 548


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score =  361 bits (927), Expect = e-100
 Identities = 208/551 (37%), Positives = 308/551 (55%), Gaps = 14/551 (2%)

Query: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
           MAF DLL   G + RFQ +Q   + +  +    H  L+NFTA IP H C      N    
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56

Query: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120
                 LS++  L + +P D   +PE C RF  PQW L  LNGT  N + A  EPC DGW
Sbjct: 57  ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGAT-EPCTDGW 109

Query: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180
           +YD  +F STIVTEWDLVC  ++L  +A+ ++M G+++G ++ G+L+DR GRR VL   Y
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169

Query: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWAT-HRFQAMGITLGMC 239
           LQ A+ GTCAA AP F IYC+ R LSG+A   +  N + L  EW   H    +G  +G  
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229

Query: 240 PSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKEL 299
            S   F+ LAG+A+A+  W  LQL+VS P+F  F+ S + +ESARW   + + +  L+ L
Sbjct: 230 YSLGQFL-LAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRAL 288

Query: 300 RKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRF 359
           ++ A  +G +     L++E+L+++++KEL    K + S  E+L  P +      LS   F
Sbjct: 289 QRVARINGKREEGAKLSMEVLRASLQKELTMG-KGQASAMELLRCPTLRHLFLCLSMLWF 347

Query: 360 ANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAI 419
           A   AY+GL + +Q  G +++L+Q +FGAV L A  V    +  + RR +QM  + L  I
Sbjct: 348 ATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGI 407

Query: 420 CLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANI 479
           C+L    +PQ+   +R  LA LG G  A +    F +  E+ PT+IR   MG+ +T A +
Sbjct: 408 CILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARV 467

Query: 480 AGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPR 539
              ++PL+ + +   P +P  IYG  P  +    +LLPET  +PL DT+QD ++ +    
Sbjct: 468 GSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRKGKQT 527

Query: 540 EPKQEDPRVEV 550
             +QE  +  V
Sbjct: 528 RQQQEHQKYMV 538


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score =  360 bits (925), Expect = 1e-99
 Identities = 210/550 (38%), Positives = 309/550 (56%), Gaps = 27/550 (4%)

Query: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
           M F ++L   G +  FQ L    L +  +    H +L+ FTA  P H C           
Sbjct: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHC-------RPPH 53

Query: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120
           +  TG           +P+  N +PE+C RFVHP       N + PN +   MEPC+DGW
Sbjct: 54  NASTGPWV--------LPMGPNGKPERCLRFVHPP------NASLPNDTQRAMEPCLDGW 99

Query: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180
           VY+  S   +IVTEWDLVC+S  L  +A+ +FMAG+++GG++ G LSDRFGRR +L   Y
Sbjct: 100 VYN--STKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSY 157

Query: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQA-MGITLGMC 239
           L +A  G+ AA +PTF IY   RFL G     +  +T++L  EW   R +A M   LG C
Sbjct: 158 LLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYC 217

Query: 240 PSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKEL 299
            +   F+ L GLA+AI  W  LQL VS+P+FV FL+S W  ES RWL+++ K  + LK L
Sbjct: 218 YTFGQFI-LPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKIL 276

Query: 300 RKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRF 359
           R+ A  +G K   + L+LE LK  ++KE+  A K K +  ++  +P + +    LS   F
Sbjct: 277 RRVAVFNGKKEEGERLSLEELKLNLQKEISLA-KAKYTASDLFRIPMLRRMTFCLSLAWF 335

Query: 360 ANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAI 419
           A   AY+ L + V+  G N+++LQ +FG V + A  +   +L Y+ R  +Q   + L   
Sbjct: 336 ATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGG 395

Query: 420 CLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANI 479
            +LA+ FVP ++QT+R VLA  G G  + + +  F + +E+ PT+IR   MG++  +  +
Sbjct: 396 AILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRV 455

Query: 480 AGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPR 539
              ++PL+ I     P +P IIYG+   + G A L LPET N+PL +TI+D +N     +
Sbjct: 456 GSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAK 515

Query: 540 EPKQEDPRVE 549
           +PKQE P VE
Sbjct: 516 KPKQE-PEVE 524


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score =  358 bits (920), Expect = 5e-99
 Identities = 205/531 (38%), Positives = 300/531 (56%), Gaps = 14/531 (2%)

Query: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
           MAF DLL   G + RFQ +Q   + +  +    H  L+NFTA IP H C      N    
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56

Query: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120
                 LS++  L + +P D   +PE C RF  PQW L  LNGT  N + A  EPC DGW
Sbjct: 57  ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGAT-EPCTDGW 109

Query: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180
           +YD  +F STIVTEWDLVC  ++L  +A+ ++M G+++G ++ G+L+DR GRR VL   Y
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169

Query: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEW-ATHRFQAMGITLGMC 239
           LQ A+ GTCAA AP F IYC+ R LSG+A   +  N + L  EW   H    +G  +G  
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229

Query: 240 PSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKEL 299
            S   F+ LAG+A+A+  W  LQL+VS P+F  F+ S + +ESARW   + + +  L+ L
Sbjct: 230 YSLGQFL-LAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRAL 288

Query: 300 RKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRF 359
           ++ A  +G +     L++E+L+++++KEL    K + S  E+L  P +      LS   F
Sbjct: 289 QRVARINGKREEGAKLSMEVLRASLQKELTMG-KGQASAMELLRCPTLRHLFLCLSMLWF 347

Query: 360 ANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAI 419
           A   AY+GL + +Q  G +++L+Q +FGAV L A  V    +  + RR +QM  + L  I
Sbjct: 348 ATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGI 407

Query: 420 CLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANI 479
           C+L    +PQ+   +R  LA LG G  A +    F +  E+ PT+IR   MG+ +T A +
Sbjct: 408 CILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARV 467

Query: 480 AGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQD 530
              ++PL+ + +   P +P  IYG  P  +    +LLPET  +PL DT+QD
Sbjct: 468 GSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQD 518


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score =  343 bits (880), Expect = 2e-94
 Identities = 205/550 (37%), Positives = 298/550 (54%), Gaps = 12/550 (2%)

Query: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
           MAF DLL   G + RFQ+  T  L +       H  L+NFTA +P H C     ++   S
Sbjct: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPA-NHTEAS 59

Query: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120
            ND+GA      LR +IPLD    PE CRRF  PQW LL  N + P    A  E C DGW
Sbjct: 60  TNDSGAW-----LRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPG---AATEGCKDGW 111

Query: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180
           VY+R  F STIV EWDLVC++++L  +A+ V+MAG++VG  + G L+DR G +  L W Y
Sbjct: 112 VYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSY 171

Query: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAM-GITLGMC 239
           LQ+A  G   A   +F  YC  RFL G+    +I N++ L+ EW   R + + GI LG  
Sbjct: 172 LQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYS 231

Query: 240 PSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKEL 299
            + +  + LAG+A+ IR W  LQ  +S P+ + FL S WL ES+RWL+++ K +  ++ L
Sbjct: 232 FT-LGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNL 290

Query: 300 RKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRF 359
           +K A  +G K   + LT E++ S ++ E  A+     S+ ++   P I K    L    F
Sbjct: 291 QKVAAMNGRKEEGERLTKEVMSSYIQSEF-ASVCTSNSILDLFRTPAIRKVTCCLMVIWF 349

Query: 360 ANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAI 419
           +N +AY+GL + +Q  G +++L+Q LFG +   A  VA   + Y+ RRA+    + L  +
Sbjct: 350 SNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGL 409

Query: 420 CLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANI 479
            ++A +FVP+  Q L    A LG G  A +    +    E+ PT IR   MG  +  A +
Sbjct: 410 MVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARL 469

Query: 480 AGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPR 539
            G  APL+  L  YS  LP + +G    ++G A  +L ETRN PL +TI   +   K+  
Sbjct: 470 GGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKEGS 529

Query: 540 EPKQEDPRVE 549
             K  + + E
Sbjct: 530 SKKHVEEKSE 539


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score =  317 bits (812), Expect = 2e-86
 Identities = 197/551 (35%), Positives = 287/551 (52%), Gaps = 58/551 (10%)

Query: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
           MAF DLL   G + RFQ +Q   + +  +    H  L+NFTA IP H C      N    
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56

Query: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120
                 LS++  L + +P D   +PE C RF  PQW L  LNGT  N + A  EPC DGW
Sbjct: 57  ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGAT-EPCTDGW 109

Query: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180
           +YD  +F STIVTEWDLVC  ++L  +A+ ++M G+++G ++ G+L+DR GRR VL   Y
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169

Query: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEW-ATHRFQAMGITLGMC 239
           LQ A+ GTCAA AP F IYC+ R LSG+A   +  N + L  EW   H    +G  +G  
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229

Query: 240 PSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKEL 299
            S   F+ LAG+A+A+  W  LQL+VS P+F  F+ S + +ESARW   + + +  L+ L
Sbjct: 230 YSLGQFL-LAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRAL 288

Query: 300 RKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRF 359
           ++ A  +G +     L++E+L+++++KEL    K + S  E+L  P +      LS   F
Sbjct: 289 QRVARINGKREEGAKLSMEVLRASLQKELTMG-KGQASAMELLRCPTLRHLFLCLSMLWF 347

Query: 360 ANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAI 419
           A   AY+GL + +Q  G +++L+Q +FGAV L A  V    +  + RR +QM  + L  I
Sbjct: 348 ATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGI 407

Query: 420 CLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANI 479
           C+L    +PQ+   +R  LA LG G  A +    F +  E+ PT+IRA            
Sbjct: 408 CILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRA------------ 455

Query: 480 AGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPR 539
                                             +LLPET  +PL DT+QD ++ +    
Sbjct: 456 --------------------------------VTVLLPETLGQPLPDTVQDLESRKGKQT 483

Query: 540 EPKQEDPRVEV 550
             +QE  +  V
Sbjct: 484 RQQQEHQKYMV 494


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score =  314 bits (805), Expect = 1e-85
 Identities = 183/468 (39%), Positives = 265/468 (56%), Gaps = 14/468 (2%)

Query: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
           MAF DLL   G + RFQ +Q   + +  +    H  L+NFTA IP H C      N    
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56

Query: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120
                 LS++  L + +P D   +PE C RF  PQW L  LNGT  N + A  EPC DGW
Sbjct: 57  ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGAT-EPCTDGW 109

Query: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180
           +YD  +F STIVTEWDLVC  ++L  +A+ ++M G+++G ++ G+L+DR GRR VL   Y
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169

Query: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEW-ATHRFQAMGITLGMC 239
           LQ A+ GTCAA AP F IYC+ R LSG+A   +  N + L  EW   H    +G  +G  
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229

Query: 240 PSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKEL 299
            S   F+ LAG+A+A+  W  LQL+VS P+F  F+ S + +ESARW   + + +  L+ L
Sbjct: 230 YSLGQFL-LAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRAL 288

Query: 300 RKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRF 359
           ++ A  +G +     L++E+L+++++KEL    K + S  E+L  P +      LS   F
Sbjct: 289 QRVARINGKREEGAKLSMEVLRASLQKELTMG-KGQASAMELLRCPTLRHLFLCLSMLWF 347

Query: 360 ANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAI 419
           A   AY+GL + +Q  G +++L+Q +FGAV L A  V    +  + RR +QM  + L  I
Sbjct: 348 ATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGI 407

Query: 420 CLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRA 467
           C+L    +PQ+   +R  LA LG G  A +    F +  E+ PT+IRA
Sbjct: 408 CILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRA 455


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score =  263 bits (671), Expect = 4e-70
 Identities = 170/545 (31%), Positives = 270/545 (49%), Gaps = 29/545 (5%)

Query: 3   FQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDN 62
           F  +L   GD  RFQI   + L +    +  +F    F      H C V  + N T +  
Sbjct: 4   FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFN-- 61

Query: 63  DTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLH---LNGTFPNTSDADMEPCVDG 119
               LS    L +S+PLD+   PE C  F  P         L+  F  T     +PC  G
Sbjct: 62  ----LSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNET-----QPCDMG 112

Query: 120 WVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWC 179
           W Y      S +  E++LVCD + L    + VFMAG++VG ++ G L DR GR+  +   
Sbjct: 113 WEYPENRLPS-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQ 171

Query: 180 YLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMC 239
            L   ++G   A  P+F +Y +LRF    A   L  + + L+ EW    ++   + L  C
Sbjct: 172 LLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQC 231

Query: 240 PSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKEL 299
              +  M LAGLA+  R+W +LQ+  + P  ++F     L ESARWL+   + +E ++ +
Sbjct: 232 NFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLI 291

Query: 300 RKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPS--LCEMLHMPNICKRISLLSFT 357
           +KAA  +  K     L+ E++   +       +K  PS    ++   P + K   ++   
Sbjct: 292 QKAASVNRRK-----LSPELMNQLVP------EKTGPSGNALDLFRHPQLRKVTLIIFCV 340

Query: 358 RFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLL 417
            F + + Y+GL+L V   G +V+L Q +FGAV + A C + + ++   R+ SQ+  + L 
Sbjct: 341 WFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLG 400

Query: 418 AICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFA 477
            +  + IIF+P ++  +  +LA +G  A+A A T+++ +  E+ PTI+R   MG+   F+
Sbjct: 401 GLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFS 460

Query: 478 NIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKD 537
            I G L PL+++L  Y   LP +IYG  P ++G    LLPET  + L DT+QD       
Sbjct: 461 RIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQD-LELGPH 519

Query: 538 PREPK 542
           PR PK
Sbjct: 520 PRSPK 524


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score =  258 bits (658), Expect = 1e-68
 Identities = 178/567 (31%), Positives = 269/567 (47%), Gaps = 40/567 (7%)

Query: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
           M F++LL   G    FQ+     L++  V   LHF+L  F A +P HRC         + 
Sbjct: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRC--------ALP 52

Query: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNT-------SDADM 113
                   QD  L   +P + +     C RF +PQ          PNT       S  ++
Sbjct: 53  GAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQ--------ALPNTTLGEERQSRGEL 104

Query: 114 E------PCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLS 167
           E      PC  GW YD   FSSTI TEWDLVC+ + L   A   F AG++VG +  G+LS
Sbjct: 105 EDEPATVPCSQGWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLS 164

Query: 168 DRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEW--A 225
           DRFGRR +L   Y+   ++G  +A + +++++   R L+G A        + L  EW   
Sbjct: 165 DRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDV 224

Query: 226 THRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARW 285
            HR  A  ++      G+  + L G  + IRDW  L L V++P     L+  W+ ESARW
Sbjct: 225 EHRTVAGVLSSTFWTGGVMLLALVG--YLIRDWRWLLLAVTLPCAPGILSLWWVPESARW 282

Query: 286 LIINNKPEEGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMP 345
           L+     +E  + L   A  +G     D+ + E +      E      ++PS  ++   P
Sbjct: 283 LLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVV---RRPSYLDLFRTP 339

Query: 346 NICKRISLLSFTRF--ANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKY 403
            + + ISL     +   NF +Y+GL+L V  LG NV+  Q LFGAV L +  +   +++Y
Sbjct: 340 RL-RHISLCCVVVWFGVNF-SYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRY 397

Query: 404 MNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPT 463
             RR +Q   +   A+     + V  +M++   VLA +G   S  A T A+   +E+ PT
Sbjct: 398 AGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPT 457

Query: 464 IIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKP 523
           ++R   MG+ A    + G+LAPL  +L      LP + YG    ++    LLLPETR   
Sbjct: 458 VLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQ 517

Query: 524 LFDTIQDEKNERKDPREPKQEDPRVEV 550
           L +TIQD + +       ++E P  +V
Sbjct: 518 LPETIQDVERKSAPTSLQEEEMPMKQV 544


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score =  253 bits (645), Expect = 4e-67
 Identities = 178/569 (31%), Positives = 269/569 (47%), Gaps = 42/569 (7%)

Query: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
           M F++LL   G    FQ+     L++  V   LHF+L  F A +P HRC         + 
Sbjct: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRC--------ALP 52

Query: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNT-------SDADM 113
                   QD  L   +P + +     C RF +PQ          PNT       S  ++
Sbjct: 53  GAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQ--------ALPNTTLGEERQSRGEL 104

Query: 114 E------PCVDGWVYDRISFSSTIVTE--WDLVCDSQSLTSVAKFVFMAGMMVGGILGGH 165
           E      PC  GW YD   FSSTI TE  WDLVC+ + L   A   F AG++VG +  G+
Sbjct: 105 EDEPATVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGY 164

Query: 166 LSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEW- 224
           LSDRFGRR +L   Y+   ++G  +A + +++++   R L+G A        + L  EW 
Sbjct: 165 LSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWL 224

Query: 225 -ATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESA 283
              HR  A  ++      G+  + L G  + IRDW  L L V++P     L+  W+ ESA
Sbjct: 225 DVEHRTVAGVLSSTFWTGGVMLLALVG--YLIRDWRWLLLAVTLPCAPGILSLWWVPESA 282

Query: 284 RWLIINNKPEEGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLH 343
           RWL+     +E  + L   A  +G     D+ + E +      E      ++PS  ++  
Sbjct: 283 RWLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVV---RRPSYLDLFR 339

Query: 344 MPNICKRISLLSFTRF--ANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWAL 401
            P + + ISL     +   NF +Y+GL+L V  LG NV+  Q LFGAV L +  +   ++
Sbjct: 340 TPRL-RHISLCCVVVWFGVNF-SYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSV 397

Query: 402 KYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVI 461
           +Y  RR +Q   +   A+     + V  +M++   VLA +G   S  A T A+   +E+ 
Sbjct: 398 RYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELY 457

Query: 462 PTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRN 521
           PT++R   MG+ A    + G+LAPL  +L      LP + YG    ++    LLLPETR 
Sbjct: 458 PTVLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQ 517

Query: 522 KPLFDTIQDEKNERKDPREPKQEDPRVEV 550
             L +TIQD + +       ++E P  +V
Sbjct: 518 AQLPETIQDVERKSAPTSLQEEEMPMKQV 546


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score =  223 bits (567), Expect = 5e-58
 Identities = 127/312 (40%), Positives = 178/312 (57%), Gaps = 1/312 (0%)

Query: 223 EWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLES 282
           EW   R + + +TL            A +A+ +RDW +LQLVVSVP+F+ FL S WL ES
Sbjct: 2   EWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAES 61

Query: 283 ARWLIINNKPEEGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEML 342
           ARWL+   + + GL+EL + A  +G    +DTLT E+L S M++EL   Q    SL  +L
Sbjct: 62  ARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPA-SLGTLL 120

Query: 343 HMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALK 402
            MP +  R  + +   FA    +FGL L +Q LG+N+FLLQ   G V + A   A   L 
Sbjct: 121 RMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLS 180

Query: 403 YMNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIP 462
           ++ RR +    + L  +C+LA   VP EM  LR  LA LGLG    A T    + +E+ P
Sbjct: 181 HLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFP 240

Query: 463 TIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNK 522
           T++R  A+G+    A     L PL+ +L V+ P LP ++YG  P +SG A LLLPET++ 
Sbjct: 241 TVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSL 300

Query: 523 PLFDTIQDEKNE 534
           PL DTIQD +N+
Sbjct: 301 PLPDTIQDVQNQ 312


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score =  187 bits (475), Expect = 2e-47
 Identities = 148/552 (26%), Positives = 255/552 (46%), Gaps = 29/552 (5%)

Query: 5   DLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLEN-FTAFIPGHRCWVHILDNDTVSDND 63
           D+L H G+   FQ  Q  FL     AT+    +   F  F P HRC      +  V++  
Sbjct: 7   DVLEHGGEFHFFQ-KQMFFLLALLSATFAPIYVGIVFLGFTPDHRC-----RSPGVAELS 60

Query: 64  TGA-LSQDALLRISIPLDS---NMRPEKCRRFVHPQWQLLHLNGTFP------NTSDADM 113
                S    L  ++P         P +CRR+    W     +   P      N S   +
Sbjct: 61  LRCGWSPAEELNYTVPGPGPAGEASPRQCRRY-EVDWNQSTFDCVDPLASLDTNRSRLPL 119

Query: 114 EPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRR 173
            PC DGWVY+  +  S+IVTE++LVC +  +  + +     G  +G +  G+++DRFGR+
Sbjct: 120 GPCRDGWVYE--TPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRK 177

Query: 174 FVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMG 233
             L    L  A  G   A++PT+      R + G+ + +      +LI E+   R++   
Sbjct: 178 LCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTV 237

Query: 234 ITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPE 293
                    +  + LAG+A+A+  W  LQ  V++P F   L    + ES RWLI  NK  
Sbjct: 238 GIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNA 297

Query: 294 EGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISL 353
           E ++ ++  A ++G        +L      ++ E E  +K  PS  +++  P I K   +
Sbjct: 298 EAMRIIKHIAKKNGK-------SLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMI 350

Query: 354 LSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLL 413
           L +  F + + Y GL +H+   G+N++L       V   A  +    +  + RR      
Sbjct: 351 LMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAAS 410

Query: 414 MFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGIN 473
             +     LA +F+P ++Q L+ +++ LG     +A  +      E+ PT IR   + I 
Sbjct: 411 NMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHIC 470

Query: 474 ATFANIAGALAPLMMI-LSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEK 532
           ++  +I G + P ++  L+     LP +++GV   ++G   LLLPET+ K L +TI++ +
Sbjct: 471 SSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAE 530

Query: 533 NERKDPREPKQE 544
           N ++ PR+ K++
Sbjct: 531 NMQR-PRKNKEK 541


>gi|169202895 PREDICTED: similar to solute carrier family 22, member
           24 [Homo sapiens]
          Length = 139

 Score =  187 bits (474), Expect = 3e-47
 Identities = 90/134 (67%), Positives = 100/134 (74%)

Query: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
           M F  LL   G L RFQI   +FL+I  +  Y H +LENF AFIPGH  WVHILDNDTVS
Sbjct: 1   MGFDMLLDQVGGLGRFQIFHLIFLTISIIIHYPHLLLENFIAFIPGHHYWVHILDNDTVS 60

Query: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120
           DNDTG LSQ ALLRISIPLDSN+RPEKCR F+HPQW LLHLN TF N S+ + EPCV GW
Sbjct: 61  DNDTGTLSQVALLRISIPLDSNLRPEKCRCFIHPQWHLLHLNVTFSNMSEPNTEPCVGGW 120

Query: 121 VYDRISFSSTIVTE 134
           VY + SF  TIVT+
Sbjct: 121 VYHQSSFLFTIVTD 134


>gi|239750073 PREDICTED: similar to solute carrier family 22, member
           24 [Homo sapiens]
          Length = 139

 Score =  187 bits (474), Expect = 3e-47
 Identities = 90/134 (67%), Positives = 100/134 (74%)

Query: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
           M F  LL   G L RFQI   +FL+I  +  Y H +LENF AFIPGH  WVHILDNDTVS
Sbjct: 1   MGFDMLLDQVGGLGRFQIFHLIFLTISIIIHYPHLLLENFIAFIPGHHYWVHILDNDTVS 60

Query: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120
           DNDTG LSQ ALLRISIPLDSN+RPEKCR F+HPQW LLHLN TF N S+ + EPCV GW
Sbjct: 61  DNDTGTLSQVALLRISIPLDSNLRPEKCRCFIHPQWHLLHLNVTFSNMSEPNTEPCVGGW 120

Query: 121 VYDRISFSSTIVTE 134
           VY + SF  TIVT+
Sbjct: 121 VYHQSSFLFTIVTD 134


>gi|239744382 PREDICTED: hypothetical protein XP_002343132 [Homo
           sapiens]
          Length = 139

 Score =  187 bits (474), Expect = 3e-47
 Identities = 90/134 (67%), Positives = 100/134 (74%)

Query: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60
           M F  LL   G L RFQI   +FL+I  +  Y H +LENF AFIPGH  WVHILDNDTVS
Sbjct: 1   MGFDMLLDQVGGLGRFQIFHLIFLTISIIIHYPHLLLENFIAFIPGHHYWVHILDNDTVS 60

Query: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120
           DNDTG LSQ ALLRISIPLDSN+RPEKCR F+HPQW LLHLN TF N S+ + EPCV GW
Sbjct: 61  DNDTGTLSQVALLRISIPLDSNLRPEKCRCFIHPQWHLLHLNVTFSNMSEPNTEPCVGGW 120

Query: 121 VYDRISFSSTIVTE 134
           VY + SF  TIVT+
Sbjct: 121 VYHQSSFLFTIVTD 134


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score =  177 bits (450), Expect = 2e-44
 Identities = 143/535 (26%), Positives = 244/535 (45%), Gaps = 26/535 (4%)

Query: 3   FQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDN 62
           + ++    G+   FQ L    LS   +      +   F    P HRC V           
Sbjct: 4   YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVP---------- 53

Query: 63  DTGALSQDALLRISIPL---DSNMRPEKCRRF---VHPQWQLLHLN-GTFPNTSDADMEP 115
           D   LS  A    ++PL   D    P  CRR+       +  L L  G   +    + E 
Sbjct: 54  DAANLSS-AWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQES 112

Query: 116 CVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFV 175
           C+DGW + +  + STIVTEW+LVC+      +   +F  G+++G  + G LSDRFGR+ V
Sbjct: 113 CLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNV 172

Query: 176 LRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGIT 235
           L                +  F ++  L  L G+  +S      +L  E      + +  T
Sbjct: 173 LFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFST 232

Query: 236 LGMCPS-GIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEE 294
           LG+C      +M L   A+ IRDW +L + +++P  +      ++ ES RWLI   + EE
Sbjct: 233 LGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEE 292

Query: 295 GLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLL 354
               +RKAA  +G+      +   I   +  ++L + +++  ++ ++L   NI + ++++
Sbjct: 293 AEVIIRKAAKANGI-----VVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNI-RMVTIM 346

Query: 355 SFTRFANF-MAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLL 413
           S   +    + YFGL+L   +L  ++F+   L   V + A  +A   L+Y+ RR S    
Sbjct: 347 SIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATA 406

Query: 414 MFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGIN 473
           +FL    LL +  VP ++  L  VL  +G      A ++ + +  E+ PT++R   +G++
Sbjct: 407 LFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVS 466

Query: 474 ATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTI 528
           +T + +   L+P  + L  Y   LP+I+ G    ++    L LPE+   PL DTI
Sbjct: 467 STASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTI 521


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score =  168 bits (426), Expect = 1e-41
 Identities = 144/566 (25%), Positives = 246/566 (43%), Gaps = 48/566 (8%)

Query: 3   FQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRC-------WVHILD 55
           F+ +  H G   RFQ +     +   ++  +H++   F    P H C        V   +
Sbjct: 6   FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHN 65

Query: 56  NDTVSDNDTGAL---SQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDAD 112
           +   S  DTGAL    Q   + + +         +C R        L     +  T    
Sbjct: 66  HSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLG----YEYTGSKK 121

Query: 113 MEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGR 172
             PCVDG++YD+ ++ ST VT+W+LVCD + L  + + +FM G+++G +  G+ SDR GR
Sbjct: 122 EFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGR 181

Query: 173 RFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAE--------W 224
           R VL      + + G  AA A  +  + + RF   + A   +    + + E        W
Sbjct: 182 RVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTW 241

Query: 225 AT---HRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLL- 280
           A+   H F A+G  L           +A   + +R W + Q+++S    V F+   W+L 
Sbjct: 242 ASVHLHSFFAVGTLL-----------VALTGYLVRTWWLYQMILST-VTVPFILCCWVLP 289

Query: 281 ESARWLIINNKPEEGLK--ELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSL 338
           E+  WL+   + EE  K  ++    +R+      + L+L++         E    +K +L
Sbjct: 290 ETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEV---QKHNL 346

Query: 339 CEMLHMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAP 398
             + +  +I KR   +    F   + ++  +L+  +LG N +L   L G V + A     
Sbjct: 347 SYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVC 406

Query: 399 WALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGN 458
            A+  + RR      +F  A+    ++ +PQ+   L  V A +G  A   A  L + +  
Sbjct: 407 IAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTA 466

Query: 459 EVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPE 518
           E+ PTI+R+ A+G  +    +A  LAP  + LS     +P +  G    +SG   L LPE
Sbjct: 467 ELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPE 526

Query: 519 TRNKPLFDTIQ-----DEKNERKDPR 539
           T  K L  T +     + +NE K  +
Sbjct: 527 TLGKRLATTWEEAAKLESENESKSSK 552


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score =  165 bits (418), Expect = 9e-41
 Identities = 118/429 (27%), Positives = 210/429 (48%), Gaps = 17/429 (3%)

Query: 105 FPNTSDADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGG 164
           FPN S A + PC  GW Y +    STIV+E+DLVC +  +  + + +   G + G    G
Sbjct: 117 FPNRS-APLVPCRGGWRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLG 173

Query: 165 HLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAE- 223
           + +DR+GR  +     L V + G   A AP F ++   RFL G+          +++ E 
Sbjct: 174 YAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEI 233

Query: 224 WATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLL-ES 282
             + + + +GI + M  + +  + L G+A+ I +W  +QL +++P F +FL   W++ ES
Sbjct: 234 VGSKQRRIVGIVIQMFFT-LGIIILPGIAYFIPNWQGIQLAITLPSF-LFLLYYWVVPES 291

Query: 283 ARWLIINNKPEEGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEML 342
            RWLI   K ++ L+ LR+ A  +G       L+    + T+  E    +   PS  +++
Sbjct: 292 PRWLITRKKGDKALQILRRIAKCNG-----KYLSSNYSEITVTDE----EVSNPSFLDLV 342

Query: 343 HMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALK 402
             P + K   +L F  F + + Y GL + +  +G N+++   + G V L    +    ++
Sbjct: 343 RTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIE 402

Query: 403 YMNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIP 462
            + RR        +  +  L   F+P+ +  LR  +ATLG     +A  + +   +E+ P
Sbjct: 403 RLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYP 462

Query: 463 TIIRARAMGINATFANIAGALAPLMMI-LSVYSPPLPWIIYGVFPFISGFAFLLLPETRN 521
           T +R   + + +   +  G +AP ++  L+     LP II+G+   I G   +LLPET+ 
Sbjct: 463 TTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKG 522

Query: 522 KPLFDTIQD 530
             L +T+ D
Sbjct: 523 IALPETVDD 531


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score =  161 bits (407), Expect = 2e-39
 Identities = 121/464 (26%), Positives = 209/464 (45%), Gaps = 21/464 (4%)

Query: 87  KCRRFVHPQWQLLHLNGTFP------NTSDADMEPCVDGWVYDRISFSSTIVTEWDLVCD 140
           +CRR+    W    L+   P      N S   + PC DGWVYD  +  S+IVTE++LVC 
Sbjct: 87  QCRRY-EVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYD--TPGSSIVTEFNLVCA 143

Query: 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYC 200
                 + +    AG + G +  G+ +DRFGR+  L    L  A+ G   A +P ++   
Sbjct: 144 DSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSML 203

Query: 201 SLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHI 260
             R L G+ +         LI E+     +     +      +  + L GLA+A+  W  
Sbjct: 204 LFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALPHWRW 263

Query: 261 LQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELRKAAHRSGMKNARDTLTLEIL 320
           LQL VS+P F+  L    + ES RWL+   +  E +K +   A ++G     D   L + 
Sbjct: 264 LQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLKMLSL- 322

Query: 321 KSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVF 380
                 E +  +K  PS  ++   P + KR  +L +  F + + Y GL LH+     N++
Sbjct: 323 ------EEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLY 376

Query: 381 LLQTLFGAVILLANC-VAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLA 439
            L  L+ A++ +    +A   +  + R     +   L     L +IF+  ++  L  ++ 
Sbjct: 377 -LDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIM 435

Query: 440 TLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMI-LSVYSPPLP 498
            +G     +A  +      E+ PT +R   + + ++  +I G + P ++  L      LP
Sbjct: 436 CVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALP 495

Query: 499 WIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKN--ERKDPRE 540
            I++ V   ++    LLLPET+   L +T++D +N   +  P+E
Sbjct: 496 LILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGRKAKPKE 539


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score =  158 bits (400), Expect = 1e-38
 Identities = 147/569 (25%), Positives = 248/569 (43%), Gaps = 39/569 (6%)

Query: 3   FQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDN 62
           + +++   G+   FQ L    LS   +    + M   F A  P HRC V           
Sbjct: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVP---------- 53

Query: 63  DTGALSQDALLRISIPL---DSNMRPEKCRRF---VHPQWQLLHLN-GTFPNTSDADMEP 115
           D   LS  A    S+PL   D    P  C R+       +  L L  G   +    + E 
Sbjct: 54  DAANLSS-AWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQES 112

Query: 116 CVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFV 175
           C+DGW + +  + ST+VTEW+LVC+      +   +F  G+++G  + G LSDRFGR+ V
Sbjct: 113 CLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNV 172

Query: 176 LRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTI---MLIAEWATHRFQAM 232
           L   +  +A+    + L    + +     L  I  M  I+N +   +L  E      + +
Sbjct: 173 L---FATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRII 229

Query: 233 GITLGMCP-SGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNK 291
             TLG+C    + +M L   A+ IRDW +L L ++VP  +      ++ ES RWLI   +
Sbjct: 230 FSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRR 289

Query: 292 PEEGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRI 351
             E    ++KAA  + +      +   I  S   +EL   +++K  + ++    NI    
Sbjct: 290 FREAEDIIQKAAKMNNI-----AVPAVIFDSV--EELNPLKQQKAFILDLFRTRNIAIMT 342

Query: 352 SLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQM 411
            +         + YF L+L   +L  + +L   L   + + A   A   L+ + RR    
Sbjct: 343 IMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIA 402

Query: 412 LLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMG 471
            ++F     LL I  VP +   L   L  LG      A ++ +    E+ PT++R  A+G
Sbjct: 403 AVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVG 462

Query: 472 INATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDE 531
           + +T + +   +AP  + L  Y+  LP+I+ G    + G   L  PE+    L +T++  
Sbjct: 463 VTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQM 522

Query: 532 KNER-----KDPRE--PKQEDPRVEVTQF 553
           +  +     K  R+    +E+P+V +T F
Sbjct: 523 QKVKWFRSGKKTRDSMETEENPKVLITAF 551


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score =  154 bits (388), Expect = 3e-37
 Identities = 124/497 (24%), Positives = 233/497 (46%), Gaps = 36/497 (7%)

Query: 67  LSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGWVYDRIS 126
           LS+   L ++IP   N     C  ++   W L  +     N +D     C DGW+Y    
Sbjct: 110 LSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLNDTDT----CQDGWIYPDAK 165

Query: 127 FSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIV 186
             S ++ E+DLVC  ++    A+ +FMAG+ +G ++   ++D+ GR   +    L + I 
Sbjct: 166 KRS-LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIF 224

Query: 187 GTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFM 246
           G   A   +F +Y   RF    + +    ++I L  EW     +A  I LG C   +  +
Sbjct: 225 GFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAVGAV 284

Query: 247 TLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLL-ESARWLIINNKPEEGLKELRKAAHR 305
            L G+A+++  W +L LV  +   + F++  W+L ES RWL++  K +E  + L  AA  
Sbjct: 285 LLTGIAYSLPHWQLLFLVGGI-LVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAA-- 341

Query: 306 SGMKNARDTLTLEILKSTMKKELEAAQKK--KPSLCEMLHMPNICKRISLLSFTRFANFM 363
                   ++  + + S +  EL+  +KK  + S+ +      +CK   ++S   F    
Sbjct: 342 --------SVNKKTIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSY 393

Query: 364 AYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLA 423
            YF L+L ++ LG +V     +   + + A     + L+ + R+ S  + +    I  L 
Sbjct: 394 TYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLL 453

Query: 424 IIFVPQ---------------EMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRAR 468
           ++F+P+               E++++  ++  L   + A   T+ F +  E++PT++RA 
Sbjct: 454 LLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRAT 513

Query: 469 AMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTI 528
            +G+  + A++AGA+  L  I+S     LP  +  V   ++     LLPETR++PL +++
Sbjct: 514 GLGL-VSLASVAGAILSL-TIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESL 571

Query: 529 QDEKNERKDPREPKQED 545
                 R   ++ K ++
Sbjct: 572 NHSSQIRNKVKDMKTKE 588


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score =  144 bits (363), Expect = 2e-34
 Identities = 107/421 (25%), Positives = 188/421 (44%), Gaps = 20/421 (4%)

Query: 121 VYDRISFSST---IVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLR 177
           ++  + FSS+   I +EW L+ +     S A   F +G+ VG I  G LSDRFGR+ V  
Sbjct: 84  IHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYL 143

Query: 178 WCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLG 237
             +    +       +P++  +   RFL G+    +     +L+ E     + A+  ++G
Sbjct: 144 TGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIG 203

Query: 238 MCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLK 297
                +     A L + IR W  L ++V++   V+FL S ++ ES RWL    +  E  +
Sbjct: 204 GLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEE 263

Query: 298 ELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFT 357
            L   A R+       +LT    +S          ++  S  ++     +     +L F 
Sbjct: 264 ALYLIAKRNRKLKCTFSLTHPANRSC---------RETGSFLDLFRYRVLLGHTLILMFI 314

Query: 358 RFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLAN--CVAPWALKYMNRRASQMLLMF 415
            F   + Y+GL L    LG +++    L G + + +   C+     K+  R+ +    + 
Sbjct: 315 WFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLC 374

Query: 416 LLAICLLAIIFVPQEMQT------LREVLATLGLGASALANTLAFAHGNEVIPTIIRARA 469
           L  +  L ++F+P++  T          L+ LG    + A  + + + +E+ PT+IR   
Sbjct: 375 LGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVG 434

Query: 470 MGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQ 529
           +G  + F+ + G +AP +  L      LP+I++G     SG   LLLPET N PL +T  
Sbjct: 435 LGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFS 494

Query: 530 D 530
           D
Sbjct: 495 D 495


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score =  133 bits (334), Expect = 5e-31
 Identities = 100/386 (25%), Positives = 169/386 (43%), Gaps = 18/386 (4%)

Query: 87  KCRRFVHPQWQLLHLNGTFP------NTSDADMEPCVDGWVYDRISFSSTIVTEWDLVCD 140
           +CRR+    W    L+   P      N S   + PC DGWVYD  +  S+IVTE++LVC 
Sbjct: 87  QCRRY-EVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYD--TPGSSIVTEFNLVCA 143

Query: 141 SQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYC 200
                 + +    AG + G +  G+ +DRFGR+  L    L  A+ G   A +P ++   
Sbjct: 144 DSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSML 203

Query: 201 SLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHI 260
             R L G+ +         LI E+     +     +      +  + L GLA+A+  W  
Sbjct: 204 LFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALPHWRW 263

Query: 261 LQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELRKAAHRSGMKNARDTLTLEIL 320
           LQL VS+P F+  L    + ES RWL+   +  E +K +   A ++G     D   L + 
Sbjct: 264 LQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLKMLSL- 322

Query: 321 KSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVF 380
                 E +  +K  PS  ++   P + KR  +L +  F + + Y GL LH+     N++
Sbjct: 323 ------EEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLY 376

Query: 381 LLQTLFGAVILLANC-VAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLA 439
            L  L+ A++ +    +A   +  + R     +   L     L +IF+  ++  L  ++ 
Sbjct: 377 -LDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIM 435

Query: 440 TLGLGASALANTLAFAHGNEVIPTII 465
            +G     +A  +      E+ PT +
Sbjct: 436 CVGRMGITIAIQMICLVNAELYPTFV 461


>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
           sapiens]
          Length = 520

 Score =  120 bits (300), Expect = 4e-27
 Identities = 138/532 (25%), Positives = 224/532 (42%), Gaps = 75/532 (14%)

Query: 26  IFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDNDTGALSQDALLRISIPLDSNMRP 85
           IF +A  LH    ++ AF P    W    +   VS   + AL+  A  R++   D +   
Sbjct: 6   IFTLAPPLHC---HYGAFPPNASGWEQPPNASGVSVA-SAALAASAASRVATSTDPS--- 58

Query: 86  EKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGWVYDRISFSST-IVTEWDLVCDSQSL 144
             C  F  P                 D   C+  W Y+ +   +T  + +WDLVCD    
Sbjct: 59  --CSGFAPP-----------------DFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQ 99

Query: 145 TSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCA---ALAPTFLIYCS 201
             + + +F+ G   G +  G+ +DRFGRR ++    L + +VG C    A A +     +
Sbjct: 100 VILEQILFILGFASGYLFLGYPADRFGRRGIV---LLTLGLVGPCGVGGAAAGSSTGVMA 156

Query: 202 LRFLSGIAAMSLITNTIMLIAEWA--THRFQAM--GITLGMCPSGIAFMTLAGLAFAIRD 257
           LRFL G     +     ++  E    T R +    G  +G+   G  F+ L GLA   +D
Sbjct: 157 LRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGV---GGHFLFL-GLALVSKD 212

Query: 258 WHILQLVVSVPYFVIFLTSSW---LLESARWLIINNKPEEGLKELRKAAHRSGMKNARDT 314
           W  LQ +++ P  ++FL   W    LESARWLI+  + EE    LR  A R+        
Sbjct: 213 WRFLQRMITAPC-ILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHG---- 267

Query: 315 LTLEILKSTMKKELEAAQKKKP-------SLCEMLHMPNICKRISLLSFTRFANFMAYFG 367
              ++L    ++ L+  +   P       S   +L+  NI K + +L FT   NF+A+  
Sbjct: 268 ---QMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFT---NFIAH-A 320

Query: 368 LNLHVQHLG-----NNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLL 422
           +    Q +G     ++ +L   L      LA       +    RR   +L M L  I  L
Sbjct: 321 IRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASL 380

Query: 423 AII----FVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFAN 478
            ++    ++ +   T   VL      A+A+ +TL  A   EVIPT +R R +G+      
Sbjct: 381 VLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAA---EVIPTTVRGRGLGLIMALGA 437

Query: 479 IAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQD 530
           + G   P   +   +   L  ++      +   + +LLPET+ K L + ++D
Sbjct: 438 LGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRD 489


>gi|170650643 solute carrier family 22, member 23 isoform a [Homo
           sapiens]
          Length = 686

 Score =  119 bits (299), Expect = 6e-27
 Identities = 114/479 (23%), Positives = 201/479 (41%), Gaps = 61/479 (12%)

Query: 107 NTSDADMEPCVDGWVYD-RISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGH 165
           N S+ D       W Y  R      +V++WDLVCD+     +AKF  + G++ G ++ G 
Sbjct: 194 NASNCDCR----AWDYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYLITGC 249

Query: 166 LSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWA 225
           ++D  GRR VL +  + + I G   AL+    ++ +LRF  G     +I     L  E  
Sbjct: 250 IADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIE-- 307

Query: 226 THRFQAMGITLGMCPSGIAFMT--------------LAGLAFAIRDWHILQLVVSVPYFV 271
                       +CP G  FM               + GLA   RDW +LQ ++  P+ +
Sbjct: 308 ------------LCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLL 355

Query: 272 IFLTSSWLLESARWLIINNKPEEGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAA 331
           + L  S   ES RWL+   + E   + +     ++ M    D   ++ +   ++KEL + 
Sbjct: 356 MLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGD---IKGVIPELEKEL-SR 411

Query: 332 QKKKPSLCEMLHMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFG---- 387
           + KK  + +++   N+ K I +L       +  +      +      V LL+  +     
Sbjct: 412 RPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYT 471

Query: 388 -AVILLANCVAPWAL-KYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLRE--------- 436
            A I L +C+A   + +++ RR   +L M L A+  L  + +   +    +         
Sbjct: 472 TASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDS 531

Query: 437 -------VLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMI 489
                    + +G+ AS    +L+     E+ PT+IR   +G+    A      AP++ +
Sbjct: 532 VKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIEL 591

Query: 490 LSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPREP--KQEDP 546
            +     L  II+     I     LLLPE+R++ L + I + ++  + P  P  K E P
Sbjct: 592 HNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGEHYTRQPLLPHKKGEQP 650


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.328    0.139    0.436 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,007,855
Number of Sequences: 37866
Number of extensions: 773580
Number of successful extensions: 2741
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 2580
Number of HSP's gapped (non-prelim): 86
length of query: 553
length of database: 18,247,518
effective HSP length: 107
effective length of query: 446
effective length of database: 14,195,856
effective search space: 6331351776
effective search space used: 6331351776
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.