Search of human proteins with 41872703

Search of human proteins with 41872703

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|41872703 sodium/hydrogen exchanger 8 [Homo sapiens]
         (581 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|41872703 sodium/hydrogen exchanger 8 [Homo sapiens]               1147   0.0  
gi|27734935 solute carrier family 9 (sodium/hydrogen exchanger),...   276   4e-74
gi|5454070 solute carrier family 9 (sodium/hydrogen exchanger), ...   267   2e-71
gi|14211919 solute carrier family 9, member 7 [Homo sapiens]          267   2e-71
gi|110227626 solute carrier family 9 (sodium/hydrogen exchanger)...   265   1e-70
gi|27777632 solute carrier family 9, isoform A1 [Homo sapiens]        233   3e-61
gi|4759144 solute carrier family 9 (sodium/hydrogen exchanger), ...   223   3e-58
gi|148727259 solute carrier family 9 (sodium/hydrogen exchanger)...   221   1e-57
gi|15529998 solute carrier family 9 (sodium/hydrogen exchanger),...   220   2e-57
gi|194239733 solute carrier family 9 (sodium/hydrogen exchanger)...   218   9e-57
gi|56786136 sperm-specific sodium proton exchanger [Homo sapiens]      49   1e-05
gi|224465231 solute carrier family 9, member 11 [Homo sapiens]         39   0.017
gi|90903231 huntingtin [Homo sapiens]                                  31   3.6  
gi|163644316 hypothetical protein LOC23255 [Homo sapiens]              31   3.6  
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]     31   3.6  
gi|29725635 otopetrin 1 [Homo sapiens]                                 30   4.7  

>gi|41872703 sodium/hydrogen exchanger 8 [Homo sapiens]
          Length = 581

 Score = 1147 bits (2968), Expect = 0.0
 Identities = 581/581 (100%), Positives = 581/581 (100%)

Query: 1   MGEKMAEEERFPNTTHEGFNVTLHTTLVVTTKLVLPTPGKPILPVQTGEQAQQEEQSSGM 60
           MGEKMAEEERFPNTTHEGFNVTLHTTLVVTTKLVLPTPGKPILPVQTGEQAQQEEQSSGM
Sbjct: 1   MGEKMAEEERFPNTTHEGFNVTLHTTLVVTTKLVLPTPGKPILPVQTGEQAQQEEQSSGM 60

Query: 61  TIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEM 120
           TIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEM
Sbjct: 61  TIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEM 120

Query: 121 FRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQAD 180
           FRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQAD
Sbjct: 121 FRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQAD 180

Query: 181 VISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTA 240
           VISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTA
Sbjct: 181 VISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTA 240

Query: 241 EGLTRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFG 300
           EGLTRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFG
Sbjct: 241 EGLTRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFG 300

Query: 301 MMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCET 360
           MMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCET
Sbjct: 301 MMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCET 360

Query: 361 CVFAFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIM 420
           CVFAFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIM
Sbjct: 361 CVFAFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIM 420

Query: 421 WFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAK 480
           WFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAK
Sbjct: 421 WFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAK 480

Query: 481 AHRRNKKDVNLSKTEKMGNTVESEHLSELTEEEYEAHYIRRQDLKGFVWLDAKYLNPFFT 540
           AHRRNKKDVNLSKTEKMGNTVESEHLSELTEEEYEAHYIRRQDLKGFVWLDAKYLNPFFT
Sbjct: 481 AHRRNKKDVNLSKTEKMGNTVESEHLSELTEEEYEAHYIRRQDLKGFVWLDAKYLNPFFT 540

Query: 541 RRLTQEDLHHGRIQMKTLTNKWYEEVRQGPSGSEDDEQELL 581
           RRLTQEDLHHGRIQMKTLTNKWYEEVRQGPSGSEDDEQELL
Sbjct: 541 RRLTQEDLHHGRIQMKTLTNKWYEEVRQGPSGSEDDEQELL 581


>gi|27734935 solute carrier family 9 (sodium/hydrogen exchanger),
           member 9 [Homo sapiens]
          Length = 645

 Score =  276 bits (706), Expect = 4e-74
 Identities = 164/432 (37%), Positives = 252/432 (58%), Gaps = 22/432 (5%)

Query: 117 EEEMFRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFL 176
           E+  F P +FF +LLPPIIF +GYSL K +FFQN+GSI  +A  GTAIS  V+G  +Y  
Sbjct: 125 EKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQNLGSILTYAFLGTAISCIVIGLIMYGF 184

Query: 177 GQADVIS------KLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILND 230
            +A + +        + TD   FGSL+SA DPV  +AIF+ LHVDP L  L+FGES+LND
Sbjct: 185 VKAMIHAGQLKNGDFHFTDCLFFGSLMSATDPVTVLAIFHELHVDPDLYTLLFGESVLND 244

Query: 231 AVSIVLTNTAEGLTRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHID 290
           AV+IVLT +    + K   +      F Q++  FL +F GS A+G+   +I+AL+ K   
Sbjct: 245 AVAIVLTYSISIYSPKENPNAFDAAAFFQSVGNFLGIFAGSFAMGSAYAIITALLTKFTK 304

Query: 291 LRKTPSLEFGMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQT 350
           L + P LE G+  + ++  +  AE   L+GI+A+LF G+  +HYT++NLS  ++I  +Q 
Sbjct: 305 LCEFPMLETGLFFLLSWSAFLSAEAAGLTGIVAVLFCGVTQAHYTYNNLSSDSKIRTKQL 364

Query: 351 LRTVAFLCETCVFAFLGLSIFSFP-HKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRD 409
              + FL E  +F ++GL++F+F  H F   F++   + +   RA NI+PLS+LLN  R 
Sbjct: 365 FEFMNFLAENVIFCYMGLALFTFQNHIFNALFILGAFLAIFVARACNIYPLSFLLNLGRK 424

Query: 410 HKITPKMMFIMWFSGLRGAIPYALSL-HLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTM 468
            KI      +M FSGLRGAI +AL++ + + +P   +Q++ TTT+++V FT+ + GG T 
Sbjct: 425 QKIPWNFQHMMMFSGLRGAIAFALAIRNTESQP---KQMMFTTTLLLVFFTVWVFGGGTT 481

Query: 469 PLIRLMDIEDAKAHRRNKKDVNLSKTEKMGNTVESEHLSELTEEEYEAHYIRRQDLKGFV 528
           P++  + I         +  V+L +  K   + + +  + L +   +A   R    + + 
Sbjct: 482 PMLTWLQI---------RVGVDLDENLKEDPSSQHQEANNLDKNMTKAESARL--FRMWY 530

Query: 529 WLDAKYLNPFFT 540
             D KYL P  T
Sbjct: 531 SFDHKYLKPILT 542


>gi|5454070 solute carrier family 9 (sodium/hydrogen exchanger),
           member 6 isoform b [Homo sapiens]
          Length = 669

 Score =  267 bits (682), Expect = 2e-71
 Identities = 161/450 (35%), Positives = 254/450 (56%), Gaps = 26/450 (5%)

Query: 49  EQAQQEEQSSGMTIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKI-- 106
           +QA++  +     +   +L+L + I+ + L    R  FL E+   +  G+L+G V++   
Sbjct: 61  KQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGI 120

Query: 107 -----IEFKKLANWKEEE------MFRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSIT 155
                +    L+   +         F P +FF +LLPPIIF +GYSL + +FF+N+GSI 
Sbjct: 121 HVPSDVNNVTLSCEVQSSPTTLLVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSIL 180

Query: 156 LFAVFGTAISAFVVGGGIY-------FLGQADVISKLNMTDSFAFGSLISAVDPVATIAI 208
            +A  GTAIS FV+G  +Y         GQ  +      TD   FG+++SA DPV  +AI
Sbjct: 181 AYAFLGTAISCFVIGSIMYGCVTLMKVTGQ--LAGDFYFTDCLLFGAIVSATDPVTVLAI 238

Query: 209 FNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGLTRK-NMSDVSGWQTFLQALDYFLKM 267
           F+ L VD  L  L+FGES+LNDAV+IVL+++        + S         +++  FL +
Sbjct: 239 FHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGI 298

Query: 268 FFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGLAEGISLSGIMAILFS 327
           F GS A+G  TG+++ALV K   LR+   LE G+  + ++  + LAE    +G++A+LF 
Sbjct: 299 FSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFC 358

Query: 328 GIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFP-HKFEISFVIWCI 386
           GI  +HYT++NLS  +Q   +Q    + FL E  +F+++GL++F+F  H F  +FV+   
Sbjct: 359 GITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAF 418

Query: 387 VLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLDLEPMEKRQ 446
           V +  GRA NI+PLS LLN  R  KI      +M F+GLRGA+ +AL++         RQ
Sbjct: 419 VAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIR--DTATYARQ 476

Query: 447 LIGTTTIVIVLFTILLLGGSTMPLIRLMDI 476
           ++ +TT++IV FT+ + GG T  ++  + I
Sbjct: 477 MMFSTTLLIVFFTVWVFGGGTTAMLSCLHI 506


>gi|14211919 solute carrier family 9, member 7 [Homo sapiens]
          Length = 725

 Score =  267 bits (682), Expect = 2e-71
 Identities = 162/484 (33%), Positives = 265/484 (54%), Gaps = 59/484 (12%)

Query: 47  TGEQAQQEEQSSGMTIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVI-- 104
           T ++A++  +   +++   +L+L + I+ + L    R+ FL E+   +  G+++G ++  
Sbjct: 59  TEKEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRY 118

Query: 105 ------------------------------KIIEFK--------KLANWKEEEMFR---- 122
                                         K  E+         K+ + ++ +M R    
Sbjct: 119 GTPATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTF 178

Query: 123 -PNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIY------- 174
            P +FF +LLPPIIF +GYSL K +FF+N+GSI  +A  GTA+S F++G  +Y       
Sbjct: 179 DPEVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMK 238

Query: 175 FLGQADVISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSI 234
            +GQ  +  K   TD   FG++ISA DPV  +AIFN LH D  L  L+FGES+LNDAV+I
Sbjct: 239 IMGQ--LSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAI 296

Query: 235 VLTNTAEGLTRKNM-SDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRK 293
           VL+++        + +       F +++  FL +F GS  +G +TG ++A V K   L  
Sbjct: 297 VLSSSIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTG-VNANVTKFTKLHC 355

Query: 294 TPSLEFGMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRT 353
            P LE  +  + ++  + LAE    +G++A+LF GI  +HYT++NLS  ++   +Q    
Sbjct: 356 FPLLETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEV 415

Query: 354 VAFLCETCVFAFLGLSIFSF-PHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKI 412
           + FL E  +F+++GL++F+F  H F   F+I   V +  GRA +I+PLS+ LN  R HKI
Sbjct: 416 LHFLAENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKI 475

Query: 413 TPKMMFIMWFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIR 472
                 +M FSGLRGA+ +AL++         RQ++ TTT++IV FT+ ++GG T P++ 
Sbjct: 476 GWNFQHMMMFSGLRGAMAFALAIRDTAS--YARQMMFTTTLLIVFFTVWIIGGGTTPMLS 533

Query: 473 LMDI 476
            ++I
Sbjct: 534 WLNI 537


>gi|110227626 solute carrier family 9 (sodium/hydrogen exchanger),
           member 6 isoform a [Homo sapiens]
          Length = 701

 Score =  265 bits (676), Expect = 1e-70
 Identities = 165/482 (34%), Positives = 258/482 (53%), Gaps = 58/482 (12%)

Query: 49  EQAQQEEQSSGMTIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKI-- 106
           +QA++  +     +   +L+L + I+ + L    R  FL E+   +  G+L+G V++   
Sbjct: 61  KQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGI 120

Query: 107 --------------------------------------IEFKKLANWKEEEMFR-----P 123
                                                 I   +L N ++ EM R     P
Sbjct: 121 HVPSDVNNVTLSCEVQSSPTTLLVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDP 180

Query: 124 NMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIY-------FL 176
            +FF +LLPPIIF +GYSL + +FF+N+GSI  +A  GTAIS FV+G  +Y         
Sbjct: 181 EVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVT 240

Query: 177 GQADVISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVL 236
           GQ  +      TD   FG+++SA DPV  +AIF+ L VD  L  L+FGES+LNDAV+IVL
Sbjct: 241 GQ--LAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVL 298

Query: 237 TNTAEGLTRK-NMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTP 295
           +++        + S         +++  FL +F GS A+G  TG+++ALV K   LR+  
Sbjct: 299 SSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQ 358

Query: 296 SLEFGMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVA 355
            LE G+  + ++  + LAE    +G++A+LF GI  +HYT++NLS  +Q   +Q    + 
Sbjct: 359 LLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLN 418

Query: 356 FLCETCVFAFLGLSIFSFP-HKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITP 414
           FL E  +F+++GL++F+F  H F  +FV+   V +  GRA NI+PLS LLN  R  KI  
Sbjct: 419 FLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGS 478

Query: 415 KMMFIMWFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLM 474
               +M F+GLRGA+ +AL++         RQ++ +TT++IV FT+ + GG T  ++  +
Sbjct: 479 NFQHMMMFAGLRGAMAFALAIR--DTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCL 536

Query: 475 DI 476
            I
Sbjct: 537 HI 538


>gi|27777632 solute carrier family 9, isoform A1 [Homo sapiens]
          Length = 815

 Score =  233 bits (595), Expect = 3e-61
 Identities = 145/429 (33%), Positives = 243/429 (56%), Gaps = 18/429 (4%)

Query: 65  SLLVLAICIILVHL-LIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEMFRP 123
           SL +L  C++ +   +I      +PES  ++ +G+L+G +IK +        +     + 
Sbjct: 106 SLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVG-------ETPPFLQS 158

Query: 124 NMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYF--LGQADV 181
           ++FFL LLPPII ++GY L    F +N+G+I +FAV GT  +AF +GG +Y   L   + 
Sbjct: 159 DVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQ 218

Query: 182 ISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAE 241
           I+ + + D+  FGS+ISAVDPVA +A+F  +H++ +L++LVFGES+LNDAV++VL +  E
Sbjct: 219 INNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFE 278

Query: 242 GLTRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGM 301
                N   V     FL  L +F+ +  G   +G + G+I+A   +     +   +E   
Sbjct: 279 EFA--NYEHVGIVDIFLGFLSFFV-VALGGVLVGVVYGVIAAFTSRFTSHIRV--IEPLF 333

Query: 302 MIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETC 361
           + +++Y+ Y  AE   LSGIMA++ SG+VM  Y   N+S  +   ++  L+  + + ET 
Sbjct: 334 VFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETL 393

Query: 362 VFAFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMW 421
           +F FLG+S  +  H +  +FVI  ++  L  R + +  L++ +N FR  K+TPK  FI+ 
Sbjct: 394 IFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIA 453

Query: 422 FSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAKA 481
           + GLRGAI ++L   LD +      L  T  I ++ FT+ + G +  PL+ L+ +   K 
Sbjct: 454 YGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAV---KK 510

Query: 482 HRRNKKDVN 490
            +  K+ +N
Sbjct: 511 KQETKRSIN 519


>gi|4759144 solute carrier family 9 (sodium/hydrogen exchanger),
           isoform 5 [Homo sapiens]
          Length = 896

 Score =  223 bits (569), Expect = 3e-58
 Identities = 143/467 (30%), Positives = 243/467 (52%), Gaps = 26/467 (5%)

Query: 33  LVLPTPGKPILPVQTGEQA------------QQEEQSSGMTIFFSLLVLAICIILVHLLI 80
           L LP  G    P Q  E              Q  E  +   +   +LV ++  I+ HL  
Sbjct: 9   LALPLAGAAEEPTQKPESPGEPPPGLELFRWQWHEVEAPYLVALWILVASLAKIVFHLS- 67

Query: 81  RYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEMFRPNMFFLLLLPPIIFESGY 140
           R     +PES  ++ LG+++G ++  +  K       E    P  FFL LLPPI+ +SGY
Sbjct: 68  RKVTSLVPESCLLILLGLVLGGIVLAVAKKA------EYQLEPGTFFLFLLPPIVLDSGY 121

Query: 141 SLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQADVIS---KLNMTDSFAFGSLI 197
            +    FF N+G+I  +AV GT  +AF  G  ++ L QA +++   +  + D   FGSLI
Sbjct: 122 FMPSRLFFDNLGAILTYAVVGTLWNAFTTGAALWGLQQAGLVAPRVQAGLLDFLLFGSLI 181

Query: 198 SAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGLTRKNMSDVSGWQTF 257
           SAVDPVA +A+F  +HV+  L ++VFGES+LNDAV++VL            ++V     +
Sbjct: 182 SAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTVVLYKVCNSFVEMGSANVQA-TDY 240

Query: 258 LQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGLAEGIS 317
           L+ +     +  G AA+G +   + AL  +    ++   +E  ++ + AY  Y  AE  S
Sbjct: 241 LKGVASLFVVSLGGAAVGLVFAFLLALTTRF--TKRVRIIEPLLVFLLAYAAYLTAEMAS 298

Query: 318 LSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLS-IFSFPHK 376
           LS I+A+   G+    Y   N+S  ++  ++ T++T+A   ET +F  LG+S + S    
Sbjct: 299 LSAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLLGISAVDSSKWA 358

Query: 377 FEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLH 436
           ++   V+  ++ +LF RA+ +   +++LN FR   +      +M + GLRGA+ +AL + 
Sbjct: 359 WDSGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFALVIL 418

Query: 437 LDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAKAHR 483
           LD   +  +     TTIV+V FT+++ G +  PL++ + ++ ++ H+
Sbjct: 419 LDRTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVKRSEHHK 465


>gi|148727259 solute carrier family 9 (sodium/hydrogen exchanger),
           member 4 [Homo sapiens]
          Length = 798

 Score =  221 bits (563), Expect = 1e-57
 Identities = 144/481 (29%), Positives = 254/481 (52%), Gaps = 25/481 (5%)

Query: 66  LLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEMFRPNM 125
           +L+ ++  I  HL  R     +PES  ++ +G L+G +I   + K         +   ++
Sbjct: 77  ILLASLAKIGFHLYHRLP-GLMPESCLLILVGALVGGIIFGTDHKS------PPVMDSSI 129

Query: 126 FFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQADV--IS 183
           +FL LLPPI+ E GY +    FF+NIGSI  +AV G  I+A  +G  +Y + Q     + 
Sbjct: 130 YFLYLLPPIVLEGGYFMPTRPFFENIGSILWWAVLGALINALGIGLSLYLICQVKAFGLG 189

Query: 184 KLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGL 243
            +N+  +  FGSLISAVDPVA +A+F    V+  L M++FGE++LND +++VL N     
Sbjct: 190 DVNLLQNLLFGSLISAVDPVAVLAVFEEARVNEQLYMMIFGEALLNDGITVVLYNMLIAF 249

Query: 244 TRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMI 303
           T+ +  +       L     F+ +  G    G + G ISA + +    +   ++E  ++ 
Sbjct: 250 TKMHKFEDIETVDILAGCARFIVVGLGGVLFGIVFGFISAFITRFT--QNISAIEPLIVF 307

Query: 304 IFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVF 363
           +F+YL Y  AE + LSGI+AI    + M  Y   N+S  +   ++  ++ ++ + ET +F
Sbjct: 308 MFSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIF 367

Query: 364 AFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFS 423
            F+G+S     H++  +F+ + +      RA+++F L Y+ N FR    + K   I+++S
Sbjct: 368 IFMGVSTVGKNHEWNWAFICFTLAFCQIWRAISVFALFYISNQFRTFPFSIKDQCIIFYS 427

Query: 424 GLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAKAHR 483
           G+RGA  ++L+  L L    ++++  T T+V++ FT+ + G +  PL+R +D++     +
Sbjct: 428 GVRGAGSFSLAFLLPLSLFPRKKMFVTATLVVIYFTVFIQGITVGPLVRYLDVK-----K 482

Query: 484 RNKKDVNLSKTEKMGNTVESEHLSELTEE--EYEAHYIRRQDLKGFVWLDAKYLNPFFTR 541
            NKK+   S  E++   +  +HL    E+   + +HY  R   K F   D +YL     R
Sbjct: 483 TNKKE---SINEELHIRL-MDHLKAGIEDVCGHWSHYQVRDKFKKF---DHRYLRKILIR 535

Query: 542 R 542
           +
Sbjct: 536 K 536


>gi|15529998 solute carrier family 9 (sodium/hydrogen exchanger),
           member 2 [Homo sapiens]
          Length = 812

 Score =  220 bits (561), Expect = 2e-57
 Identities = 134/409 (32%), Positives = 229/409 (55%), Gaps = 18/409 (4%)

Query: 87  LPESVAVVSLGILMGAVIKIIEFKKLANWKEEEMFRPNMFFLLLLPPIIFESGYSLHKGN 146
           +PES  ++ +G+L+G +I  ++ K     K +      +FFL LLPPI+ ++GY +    
Sbjct: 108 VPESCLLIMVGLLLGGIIFGVDEKSPPAMKTD------VFFLYLLPPIVLDAGYFMPTRP 161

Query: 147 FFQNIGSITLFAVFGTAISAFVVGGGIYFLGQADV--ISKLNMTDSFAFGSLISAVDPVA 204
           FF+NIG+I  +AV GT  ++  +G  ++ + Q +   +S + +  +  FGSLISAVDPVA
Sbjct: 162 FFENIGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVA 221

Query: 205 TIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGLTRKNMSDVSGWQTFLQALDYF 264
            +A+F  +HV+  L +LVFGES+LNDAV++VL N  +   +  M  +     F    ++F
Sbjct: 222 VLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQ--MKTIETIDVFAGIANFF 279

Query: 265 LKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGLAEGISLSGIMAI 324
           + +  G   +G   G I+A   +     +   +E   + +++YL Y  AE   LSGIMAI
Sbjct: 280 V-VGIGGVLIGIFLGFIAAFTTRFTHNIRV--IEPLFVFLYSYLSYITAEMFHLSGIMAI 336

Query: 325 LFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFPHKFEISFVIW 384
               + M+ Y   N+S  +   ++  ++ ++ + ET +F F+G+S     H++  +FV +
Sbjct: 337 TACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCF 396

Query: 385 CIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLDLEPMEK 444
            +   L  RA+ +F L+ ++N FR   +T K  FI+ + GLRGAI +AL   L      +
Sbjct: 397 TLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPR 456

Query: 445 RQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAKAHRRNKKDVNLSK 493
           ++L  T  IV++ FT+ +LG +  PL+  +D++     R NKK   +S+
Sbjct: 457 KKLFITAAIVVIFFTVFILGITIRPLVEFLDVK-----RSNKKQQAVSE 500


>gi|194239733 solute carrier family 9 (sodium/hydrogen exchanger),
           isoform 3 [Homo sapiens]
          Length = 834

 Score =  218 bits (556), Expect = 9e-57
 Identities = 150/491 (30%), Positives = 260/491 (52%), Gaps = 36/491 (7%)

Query: 66  LLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEM----F 121
           +LV ++  I  HL  +     +PES  ++ LG+++G ++          W  + +     
Sbjct: 62  ILVASLAKIGFHLSHKVT-SVVPESALLIVLGLVLGGIV----------WAADHIASFTL 110

Query: 122 RPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIY--FLGQA 179
            P +FF  LLPPI+ ++GY +    FF N+G+I L+AV GT  +A   G  +Y  FL   
Sbjct: 111 TPTVFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGL 170

Query: 180 DVISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNT 239
               ++ + D   FGSL++AVDPVA +A+F  +HV+ VL ++VFGES+LNDAV++VL N 
Sbjct: 171 MGDLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNV 230

Query: 240 AEGLTRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHID--LRKTPSL 297
            E        +V+G       + +F+      +  GTL G++ A +L  +    +    +
Sbjct: 231 FESFVALGGDNVTGVDCVKGIVSFFV-----VSLGGTLVGVVFAFLLSLVTRFTKHVRII 285

Query: 298 EFGMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFL 357
           E G + I +YL Y  +E +SLS I+AI F GI    Y   N+S  +   ++ T++ +A  
Sbjct: 286 EPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASS 345

Query: 358 CETCVFAFLGLS-IFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKM 416
            ET +F FLG+S +  F   +  +FV+  +V +   RA+ +   ++LLN +R  ++ P  
Sbjct: 346 AETIIFMFLGISAVNPFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPID 405

Query: 417 MFIMWFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDI 476
             ++ + GLRGA+ +AL + LD + ++++ L  +TTI++V FT++  G +  PL++ + +
Sbjct: 406 QVVLSYGGLRGAVAFALVVLLDGDKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKV 465

Query: 477 EDAKAHRRNKKDVNLSKTEKMGNTVESEHLSELTEEEYE-AHYIRRQDLKGFVWLDAKYL 535
           + ++ HR  + +      EK+        LS + +   +  H   R     F   D K+L
Sbjct: 466 KRSE-HREPRLN------EKLHGRAFDHILSAIEDISGQIGHNYLRDKWSHF---DRKFL 515

Query: 536 NPFFTRRLTQE 546
           +    RR  Q+
Sbjct: 516 SRVLMRRSAQK 526


>gi|56786136 sperm-specific sodium proton exchanger [Homo sapiens]
          Length = 1177

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 97/452 (21%), Positives = 192/452 (42%), Gaps = 64/452 (14%)

Query: 63  FFSLLVLAICIILVHLL------IRYRLHFLPESVAVVSLGILMGAVIKIIEF-----KK 111
           FFS   L   I+ + L+      +   L   P  V V+    L+G   +++ F     ++
Sbjct: 9   FFSTEDLPEVILTLSLISSIGAFLNRHLEDFPIPVPVILF--LLGCSFEVLSFTSSQVQR 66

Query: 112 LANWKEEEMFRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGG 171
            AN    +   P++FF +  P + F + + +      +    I L ++ G  ++  +V  
Sbjct: 67  YAN--AIQWMSPDLFFRIFTPVVFFTTAFDMDTYMLQKLFWQILLISIPGFLVNYILV-- 122

Query: 172 GIYFLGQADVISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDA 231
            ++ L   + +  L  T    F +++ + DP+ T A    L +   L  L+ GES++   
Sbjct: 123 -LWHLASVNQLL-LKPTQWLLFSAILVSSDPMLTAAAIRDLGLSRSLISLINGESLMTSV 180

Query: 232 VSIVLTNTAEGLTRKNMSD---------VSGWQTFLQALDYFLKMFFGSAALGTLTGLIS 282
           +S++   +     ++  S          V G  +++ A   FL     S  +      + 
Sbjct: 181 ISLITFTSIMDFDQRLQSKRNHTLAEEIVGGICSYIIA--SFLFGILSSKLIQFWMSTVF 238

Query: 283 ALVLKHIDLRKTPSLEFGMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPV 342
              + HI      SL F ++    YL + + E + +SGI  +   G++++  +       
Sbjct: 239 GDDVNHI------SLIFSIL----YLIFYICELVGMSGIFTLAIVGLLLNSTSFKAAIEE 288

Query: 343 TQILMQQT-LRTVAFLCETCVFAFLGLSIFSFPHKFEISFV-------IWCIVLVLFGRA 394
           T +L   T L  +AFL    VF F GL I +  + + I FV       I+  ++VL  R 
Sbjct: 289 TLLLEFWTFLSRIAFL---MVFTFFGLLIPAHTYLY-IEFVDIYYSLNIYLTLIVL--RF 342

Query: 395 VNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLDLEPM------EKRQLI 448
           + +  +S +L+    H+ + + +FIM  S ++G     ++L L    +      EK Q++
Sbjct: 343 LTLLLISPVLSRV-GHEFSWRWIFIMVCSEMKGMPNINMALLLAYSDLYFGSDKEKSQIL 401

Query: 449 GTTTIVIVLFTILLLGGSTMPL-IRLMDIEDA 479
                V+V    L++    +P+ + ++ + DA
Sbjct: 402 FHG--VLVCLITLVVNRFILPVAVTILGLRDA 431


>gi|224465231 solute carrier family 9, member 11 [Homo sapiens]
          Length = 1124

 Score = 38.5 bits (88), Expect = 0.017
 Identities = 68/354 (19%), Positives = 141/354 (39%), Gaps = 32/354 (9%)

Query: 193 FGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGLTRKNMSDVS 252
           F   +  +DP+ ++     + +  +   L+ GES++  +++ +      G  R + S   
Sbjct: 155 FSITLGIIDPLRSVNSLKTIGISKIYIDLIRGESLIICSIASIFFGNFRG-NRIHFSIFR 213

Query: 253 GWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGL 312
                ++ L Y +    GS   G     I   +L   D+         +     Y+ + +
Sbjct: 214 DLHVGIE-LSYDI---LGSIIFGYWCAKIIQCIL--ADVFSNMLTNIILCFSMVYMTFYI 267

Query: 313 AEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSI-- 370
            E + +SG +A+   G+ +   T     P  ++++ + LR  + + E  ++AF G+ I  
Sbjct: 268 VEFLGMSGTLALAAVGLNLDSLT---FKPKIELVITKFLRIFSSVYEHLIYAFFGIVIGC 324

Query: 371 --FSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGA 428
              S      I F+      V   R + I  +S +L    +++   +   ++ +SG++G 
Sbjct: 325 GELSHYEFHTIPFIFILFTTVNLVRLLTILLVSPIL-MHSNYEYNWRWGVVITWSGIKGV 383

Query: 429 IPYALS---LHLDLEPMEKRQLIGTTTIVIVLFTILL-----------LGGSTMPLIRLM 474
                +    +L    +E  Q+      VI L T+ +           L    + L R M
Sbjct: 384 FNLLWAPDVYNLAERKVEVPQMFILYVQVISLLTMGINSYVMTQSARKLDLCVLSLPRQM 443

Query: 475 DIEDAKAHRRN--KKDVNLSKTEKMGNTVESEHLSELTEEEY-EAHYIRRQDLK 525
            +++A  H +   +  + L KTEK+   V    + + T  EY    ++   D+K
Sbjct: 444 ILQNATQHIQEIVQNTITLFKTEKILTNVNWTLVEDKTRIEYIPFSHVSHNDMK 497


>gi|90903231 huntingtin [Homo sapiens]
          Length = 3144

 Score = 30.8 bits (68), Expect = 3.6
 Identities = 20/64 (31%), Positives = 33/64 (51%), Gaps = 8/64 (12%)

Query: 68   VLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEMFRPNMFF 127
            VL +   LV L + Y L        + S  + +G V+K  E+ ++  ++E E   PN+FF
Sbjct: 1450 VLDLLAQLVQLRVNYCL--------LDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIFF 1501

Query: 128  LLLL 131
             L+L
Sbjct: 1502 FLVL 1505


>gi|163644316 hypothetical protein LOC23255 [Homo sapiens]
          Length = 1586

 Score = 30.8 bits (68), Expect = 3.6
 Identities = 33/125 (26%), Positives = 55/125 (44%), Gaps = 10/125 (8%)

Query: 458 FTILLLGGSTMPLIRLMDIEDAKAHRRNKKDVNLSKTEKMGNTV---ESEHLSELTEEEY 514
           F++ L G   +P  + + IE+ +        ++  +TE   N +   E EHL  L  +E 
Sbjct: 626 FSLELRGPPVLPE-QSVSIEELQGQLVQAARLHQEETETFTNKIHKMEEEHLYALRWKEL 684

Query: 515 EAHYIRRQD-LKGFVWLDAKYLNPFFTRRLTQEDLHHGRIQMKTLTNKWYEEVRQGPSGS 573
           E H +  Q+ L    W D K L     R L Q ++    ++++ L   W    RQG    
Sbjct: 685 EMHSLALQNTLHERTWSDEKNLMQQELRSLKQ-NIFLFYVKLRWLLKHW----RQGKQME 739

Query: 574 EDDEQ 578
           E+ E+
Sbjct: 740 EEGEE 744


>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
          Length = 771

 Score = 30.8 bits (68), Expect = 3.6
 Identities = 11/28 (39%), Positives = 19/28 (67%)

Query: 552 RIQMKTLTNKWYEEVRQGPSGSEDDEQE 579
           R+ +  + N ++E+  QGP G EDD++E
Sbjct: 237 RLSLMAMPNGFHEDGPQGPGGDEDDDEE 264


>gi|29725635 otopetrin 1 [Homo sapiens]
          Length = 612

 Score = 30.4 bits (67), Expect = 4.7
 Identities = 24/92 (26%), Positives = 41/92 (44%), Gaps = 16/92 (17%)

Query: 152 GSITLFAVFGTAISAFVVGGGIYFLGQADVISKLN----MTDS--------FAFGSLISA 199
           GSITLFAV    +    +G   YF+G ++ +S       +T S        F +G     
Sbjct: 135 GSITLFAVITVILGCLKIG---YFIGFSECLSATEGVFPVTHSVHTLLQVYFLWGHAKDI 191

Query: 200 VDPVATIAIFNALHVDPVLNMLVFGESILNDA 231
           +    T+  F  +H     N+L++   +LN++
Sbjct: 192 IQSFKTLERFGVIH-SVFTNLLLWANGVLNES 222


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.141    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,897,678
Number of Sequences: 37866
Number of extensions: 818222
Number of successful extensions: 2595
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 2547
Number of HSP's gapped (non-prelim): 17
length of query: 581
length of database: 18,247,518
effective HSP length: 108
effective length of query: 473
effective length of database: 14,157,990
effective search space: 6696729270
effective search space used: 6696729270
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.