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Search of human proteins with 41872527
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens]
(895 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens] 1854 0.0
gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens] 1810 0.0
gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens] 1803 0.0
gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens] 1803 0.0
gi|4758156 diacylglycerol kinase, iota [Homo sapiens] 1157 0.0
gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens] 293 4e-79
gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens] 288 2e-77
gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens] 285 1e-76
gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 279 7e-75
gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 279 7e-75
gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 279 7e-75
gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 279 7e-75
gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens] 270 6e-72
gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens] 249 6e-66
gi|40806175 diacylglycerol kinase, theta [Homo sapiens] 238 2e-62
gi|4503313 diacylglycerol kinase epsilon [Homo sapiens] 217 3e-56
gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens] 152 1e-36
gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens] 152 1e-36
gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo ... 151 3e-36
gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ... 151 3e-36
gi|62000702 diacylglycerol kinase kappa [Homo sapiens] 134 4e-31
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 57 6e-08
gi|20270347 ankyrin repeat domain 54 [Homo sapiens] 54 8e-07
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 53 1e-06
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 53 1e-06
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun... 51 5e-06
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit... 51 5e-06
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 50 7e-06
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 50 7e-06
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 50 7e-06
>gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens]
Length = 895
Score = 1854 bits (4802), Expect = 0.0
Identities = 895/895 (100%), Positives = 895/895 (100%)
Query: 1 MWRYRSWDVPQIPSEAPQTQKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESAT 60
MWRYRSWDVPQIPSEAPQTQKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESAT
Sbjct: 1 MWRYRSWDVPQIPSEAPQTQKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESAT 60
Query: 61 YGEHIWFETNVSGDFCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCK 120
YGEHIWFETNVSGDFCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCK
Sbjct: 61 YGEHIWFETNVSGDFCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCK 120
Query: 121 PSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQA 180
PSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQA
Sbjct: 121 PSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQA 180
Query: 181 YHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKK 240
YHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKK
Sbjct: 181 YHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKK 240
Query: 241 GPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGP 300
GPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGP
Sbjct: 241 GPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGP 300
Query: 301 KEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWG 360
KEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWG
Sbjct: 301 KEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWG 360
Query: 361 GGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSL 420
GGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSL
Sbjct: 361 GGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSL 420
Query: 421 GFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDL 480
GFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDL
Sbjct: 421 GFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDL 480
Query: 481 TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQ 540
TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQ
Sbjct: 481 TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQ 540
Query: 541 VGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPL 600
VGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPL
Sbjct: 541 VGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPL 600
Query: 601 HSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIER 660
HSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIER
Sbjct: 601 HSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIER 660
Query: 661 LQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPE 720
LQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPE
Sbjct: 661 LQQEPDGAGAKSPTCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPE 720
Query: 721 LLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAG 780
LLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAG
Sbjct: 721 LLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAG 780
Query: 781 GDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTI 840
GDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTI
Sbjct: 781 GDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTI 840
Query: 841 CHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV 895
CHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
Sbjct: 841 CHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV 895
>gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens]
Length = 929
Score = 1810 bits (4687), Expect = 0.0
Identities = 875/876 (99%), Positives = 876/876 (100%)
Query: 20 QKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVG 79
+KAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVG
Sbjct: 54 RKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVG 113
Query: 80 EQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRH 139
EQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRH
Sbjct: 114 EQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRH 173
Query: 140 HWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSL 199
HWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSL
Sbjct: 174 HWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSL 233
Query: 200 GVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPL 259
GVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPL
Sbjct: 234 GVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPL 293
Query: 260 MKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACG 319
MKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACG
Sbjct: 294 MKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACG 353
Query: 320 GDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGN 379
GDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGN
Sbjct: 354 GDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGN 413
Query: 380 VVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPE 439
VVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPE
Sbjct: 414 VVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPE 473
Query: 440 KFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPR 499
KFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPR
Sbjct: 474 KFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPR 533
Query: 500 YCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTS 559
YCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTS
Sbjct: 534 YCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTS 593
Query: 560 KAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVS 619
KAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVS
Sbjct: 594 KAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVS 653
Query: 620 MHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLS 679
MHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLS
Sbjct: 654 MHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLS 713
Query: 680 PKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPT 739
PKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPT
Sbjct: 714 PKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPT 773
Query: 740 SPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVS 799
SPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVS
Sbjct: 774 SPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVS 833
Query: 800 TGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGD 859
TGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGD
Sbjct: 834 TGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGD 893
Query: 860 TPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV 895
TPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
Sbjct: 894 TPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV 929
>gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens]
Length = 945
Score = 1803 bits (4670), Expect = 0.0
Identities = 874/876 (99%), Positives = 875/876 (99%), Gaps = 1/876 (0%)
Query: 20 QKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVG 79
+KAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVG
Sbjct: 71 RKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVG 130
Query: 80 EQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRH 139
EQYCVARML KSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRH
Sbjct: 131 EQYCVARML-KSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRH 189
Query: 140 HWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSL 199
HWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSL
Sbjct: 190 HWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSL 249
Query: 200 GVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPL 259
GVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPL
Sbjct: 250 GVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPL 309
Query: 260 MKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACG 319
MKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACG
Sbjct: 310 MKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACG 369
Query: 320 GDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGN 379
GDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGN
Sbjct: 370 GDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGN 429
Query: 380 VVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPE 439
VVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPE
Sbjct: 430 VVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPE 489
Query: 440 KFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPR 499
KFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPR
Sbjct: 490 KFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPR 549
Query: 500 YCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTS 559
YCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTS
Sbjct: 550 YCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTS 609
Query: 560 KAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVS 619
KAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVS
Sbjct: 610 KAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVS 669
Query: 620 MHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLS 679
MHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLS
Sbjct: 670 MHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLS 729
Query: 680 PKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPT 739
PKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPT
Sbjct: 730 PKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPT 789
Query: 740 SPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVS 799
SPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVS
Sbjct: 790 SPCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVS 849
Query: 800 TGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGD 859
TGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGD
Sbjct: 850 TGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGD 909
Query: 860 TPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV 895
TPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
Sbjct: 910 TPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV 945
>gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens]
Length = 1117
Score = 1803 bits (4669), Expect = 0.0
Identities = 874/875 (99%), Positives = 874/875 (99%), Gaps = 1/875 (0%)
Query: 21 KAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGE 80
KAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGE
Sbjct: 244 KAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGE 303
Query: 81 QYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHH 140
QYCVARML KSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHH
Sbjct: 304 QYCVARML-KSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHH 362
Query: 141 WVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLG 200
WVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLG
Sbjct: 363 WVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLG 422
Query: 201 VHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLM 260
VHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLM
Sbjct: 423 VHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLM 482
Query: 261 KPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGG 320
KPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGG
Sbjct: 483 KPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGG 542
Query: 321 DGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNV 380
DGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNV
Sbjct: 543 DGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNV 602
Query: 381 VQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEK 440
VQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEK
Sbjct: 603 VQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEK 662
Query: 441 FNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRY 500
FNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRY
Sbjct: 663 FNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRY 722
Query: 501 CAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSK 560
CAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSK
Sbjct: 723 CAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSK 782
Query: 561 AIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSM 620
AIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSM
Sbjct: 783 AIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSM 842
Query: 621 HDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSP 680
HDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSP
Sbjct: 843 HDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSP 902
Query: 681 KWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTS 740
KWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTS
Sbjct: 903 KWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTS 962
Query: 741 PCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVST 800
PCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVST
Sbjct: 963 PCSPTPRSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVST 1022
Query: 801 GSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDT 860
GSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDT
Sbjct: 1023 GSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDT 1082
Query: 861 PRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV 895
PRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
Sbjct: 1083 PRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV 1117
>gi|4758156 diacylglycerol kinase, iota [Homo sapiens]
Length = 1065
Score = 1157 bits (2993), Expect = 0.0
Identities = 579/945 (61%), Positives = 709/945 (75%), Gaps = 82/945 (8%)
Query: 20 QKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVG 79
+KAI+++GLQHLAP P + ++ R+T+DWSE+A GEH+W ETNVSGD CY+G
Sbjct: 134 RKAISRAGLQHLAPAHPLSLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLG 193
Query: 80 EQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRH 139
E+ C R KS RRKCA CKIVVHT CIEQLEKINFRCKP+FRE GSR+ RE FVRH
Sbjct: 194 EENCQVRFA-KSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRE-NFVRH 251
Query: 140 HWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSL 199
HWVHRRRQ+GKC+ CGKGFQQKF+FHSKEIVAISCSWCKQA+H+KV+CFML IEEPCSL
Sbjct: 252 HWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSL 311
Query: 200 GVHAAVVIPPTWILRARRPQNTLKAS-KKKKRASFKRKSSKKGPE-EGRWRPFIIRPTPS 257
G HAAV++PPTWI++ ++PQN+LKAS +KKKR SFKRK+SK+G E E + RPF+I+P S
Sbjct: 312 GAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISS 371
Query: 258 PLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILA 317
PLMKPLLVFVNPKSGGNQG K++Q F+WYLNPRQVFDLSQ GPK+ALE+YRKV NLRILA
Sbjct: 372 PLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILA 431
Query: 318 CGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEE 377
CGGDGTVGWILS LD+L+L P PPV +LPLGTGNDLARTLNWGGGYTDEPVSKIL VE+
Sbjct: 432 CGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVED 491
Query: 378 GNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREAN 437
G VVQLDRW+LH E NP+ PE+ ++G +LPL+VFNNYFSLGFDAHVTLEFHESREAN
Sbjct: 492 GTVVQLDRWNLHVERNPDLPPEELEDGVC-KLPLNVFNNYFSLGFDAHVTLEFHESREAN 550
Query: 438 PEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNI 497
PEKFNSRFRNKMFYAG AFSDFL SS+DL+KH++VVCDG DLTPKIQ+LK QC+VFLNI
Sbjct: 551 PEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQELKFQCIVFLNI 610
Query: 498 PRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLT 557
PRYCAGTMPWG+PG+HHDFEPQRHDDGY+EVIGFTM SLAALQVGGHGERL QCREV+L
Sbjct: 611 PRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLL 670
Query: 558 TSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSR 617
T K+IP+QVDGEPC+LA + IRI+LRNQA MVQK+KRR++ PL +D Q VP++LRI+V++
Sbjct: 671 TYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDPQSVPDRLRIRVNK 730
Query: 618 VSMHDYEALHYDKEQLKEAS------------------VPLGTVVVPGDSDLELCRAHIE 659
+S+ DYE HYDKE+L+EAS +PLG +VV GD DLE CR +I+
Sbjct: 731 ISLQDYEGFHYDKEKLREASISDWLRTIAGELVQSFGAIPLGILVVRGDCDLETCRMYID 790
Query: 660 RLQQEPDGAGAKSP---------------TCQKLSPKWCFLDATTASRFYRIDRAQEHLN 704
RLQ++ + S + Q+LSP+WCFLD DR+QEHL+
Sbjct: 791 RLQEDLQSVSSGSQRVHYQDHETSFPRALSAQRLSPRWCFLD----------DRSQEHLH 840
Query: 705 YVTEIAQDEIYILDPELLGAS------ARPDLPTPTSPLPTSPCSPTPR------SLQGD 752
+V EI+QDEI+ILDP+++ + PDL + + +P R S G
Sbjct: 841 FVMEISQDEIFILDPDMVVSQPAGTPPGMPDLVVEQASGISDWWNPALRKRMLSDSGLGM 900
Query: 753 AAP---------------------PQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSR 791
AP + +++A D KL E ++ GG L+ +
Sbjct: 901 IAPYYEDSDLKDLSHSRVLQSPVSSEDHAILQAVIAGDLMKLIESYKNGGSLLIQGPDHC 960
Query: 792 TLLHHAVSTGSKDVVRYLLDHAPPEILD-AVEENGETCLHQAAALGQRTICHYIVEAGAS 850
+LLH+A TG+ ++V+Y+LDH P E+LD A E GET LH+AA R +C +V+AGAS
Sbjct: 961 SLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGAS 1020
Query: 851 LMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV 895
L KTD +G TP++RA++A D +LAAYLE+RQ+Y++I ED ETAV
Sbjct: 1021 LRKTDSKGKTPQERAQQAGDPDLAAYLESRQNYKVIGHEDLETAV 1065
>gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens]
Length = 804
Score = 293 bits (751), Expect = 4e-79
Identities = 188/573 (32%), Positives = 276/573 (48%), Gaps = 79/573 (13%)
Query: 62 GEHIWFETNVSGD-FCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCK 120
G+H+W + + +C + C+ ++ C+ CK VH C+ R
Sbjct: 243 GQHVWRLKHFNKPAYCNL----CLNMLIGVGKQGLCCSFCKYTVHERCVA-------RAP 291
Query: 121 PSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQA 180
PS ++ ++ R + H+WV KC C K + + + + C WC+
Sbjct: 292 PSCIKTYVKSKRNTDVMHHYWVEGNCPT-KCDKCHKTVKCY-----QGLTGLHCVWCQIT 345
Query: 181 YHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWI---LRARRPQNTLKASKKKKRASFKRKS 237
H+K + ++ C G ++PPT I + P + + ++++ K KS
Sbjct: 346 LHNKCA----SHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKS 401
Query: 238 SKKGPEEGRWRPFIIRP------------TPSPLMKPLLVFVNPKSGGNQGAKIIQSFLW 285
+ P + + + R TP P PLLVFVNPKSGG QG +I + F +
Sbjct: 402 GSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQY 461
Query: 286 YLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAIL 345
LNPRQV+ LS GP L +R V + R+LACGGDGTVGW+L +++ + PPVAIL
Sbjct: 462 LLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAIL 521
Query: 346 PLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGA 405
PLGTGNDLAR L WGGGY E + KIL +E + LDRW PN D+DE
Sbjct: 522 PLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPN------DKDEKG 575
Query: 406 TDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSK 465
D +P + NNYFS+G DA + FH RE +PEKFNSR +NK +Y S+ + K
Sbjct: 576 -DPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCK 634
Query: 466 DLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD---------- 515
L + + + CDG+ + + ++ + + LNIP G+ WG +
Sbjct: 635 KLHESVEIECDGVQI--DLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSD 692
Query: 516 ------------FEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVL 556
F Q D LEV+G A+++G G RL QC VV+
Sbjct: 693 KRTTVTDAKELKFASQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCSCVVI 748
Query: 557 TTSKAIPVQVDGEPCKLAASRIRIALRNQATMV 589
TSK++P+Q+DGEP I+I +NQA M+
Sbjct: 749 RTSKSLPMQIDGEPWMQTPCTIKITHKNQAPML 781
>gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens]
Length = 791
Score = 288 bits (737), Expect = 2e-77
Identities = 193/572 (33%), Positives = 274/572 (47%), Gaps = 80/572 (13%)
Query: 53 VDWSESATYGEHIW----FETNVSGDFCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPC 108
+D S S G H W F+ +FC++ ++ C CK VH C
Sbjct: 261 MDDSGSKGDGRHAWTMKHFKKPTYCNFCHI-------MLMGVRKQGLCCTYCKYTVHERC 313
Query: 109 IEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKE 168
+ R P ++ S+ R ++H WV KC C K + +
Sbjct: 314 VS-------RNIPGCVKTYSKAKRSGEVMQHAWVEGN-SSVKCDRCHKSIKCY-----QS 360
Query: 169 IVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKK 228
+ A C WC+ +H K ++ C G ++ PT I R + K+
Sbjct: 361 VTARHCVWCRMTFHRKC------ELSTLCDGGELRDHILLPTSICPITRDRPGEKSD--- 411
Query: 229 KRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLN 288
S KG +++ I PTP PLLV VNPKSGG QG +I++ F + LN
Sbjct: 412 ------GCVSAKGELVMQYK---IIPTPG--THPLLVLVNPKSGGRQGERILRKFHYLLN 460
Query: 289 PRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLG 348
P+QVF+L GGP L +R + R+LACGGDGTVGWIL +D+ PPVA+LPLG
Sbjct: 461 PKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLG 520
Query: 349 TGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDR 408
TGNDLAR L WGGGY ++KIL +E+ +V LDRW L P E+ + G D+
Sbjct: 521 TGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPR-----EEVENG--DQ 573
Query: 409 LPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLA 468
+P + NNYFS+G DA + FH RE +PEKFNSR +NK++Y S+ + K L
Sbjct: 574 VPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLH 633
Query: 469 KHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHH-------------- 514
HI + CDG+ + + ++ + + LNIP GT WG ++
Sbjct: 634 DHIELECDGVGV--DLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPK 691
Query: 515 --DFEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVLTTSKAIPVQ 565
F Q D LEV+G A+++G G RL QC V + T+K +P+Q
Sbjct: 692 ELKFCVQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQ 747
Query: 566 VDGEPCKLAASRIRIALRNQATMVQKAKRRSA 597
VDGEP I+I +NQA M+ ++S+
Sbjct: 748 VDGEPWMQPCCTIKITHKNQAPMMMGPPQKSS 779
>gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens]
Length = 773
Score = 285 bits (730), Expect = 1e-76
Identities = 182/554 (32%), Positives = 267/554 (48%), Gaps = 79/554 (14%)
Query: 62 GEHIWFETNVSGD-FCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCK 120
G+H+W + + +C + C+ ++ C+ CK VH C+ R
Sbjct: 243 GQHVWRLKHFNKPAYCNL----CLNMLIGVGKQGLCCSFCKYTVHERCVA-------RAP 291
Query: 121 PSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQA 180
PS ++ ++ R + H+WV KC C K + + + + C WC+
Sbjct: 292 PSCIKTYVKSKRNTDVMHHYWVEGNCPT-KCDKCHKTVKCY-----QGLTGLHCVWCQIT 345
Query: 181 YHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWI---LRARRPQNTLKASKKKKRASFKRKS 237
H+K + ++ C G ++PPT I + P + + ++++ K KS
Sbjct: 346 LHNKCA----SHLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKS 401
Query: 238 SKKGPEEGRWRPFIIRP------------TPSPLMKPLLVFVNPKSGGNQGAKIIQSFLW 285
+ P + + + R TP P PLLVFVNPKSGG QG +I + F +
Sbjct: 402 GSQQPNKVIDKNKMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQY 461
Query: 286 YLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAIL 345
LNPRQV+ LS GP L +R V + R+LACGGDGTVGW+L +++ + PPVAIL
Sbjct: 462 LLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAIL 521
Query: 346 PLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGA 405
PLGTGNDLAR L WGGGY E + KIL +E + LDRW PN D+DE
Sbjct: 522 PLGTGNDLARCLRWGGGYEGENLMKILKDIENSTEIMLDRWKFEVIPN------DKDEKG 575
Query: 406 TDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSK 465
D +P + NNYFS+G DA + FH RE +PEKFNSR +NK +Y S+ + K
Sbjct: 576 -DPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCK 634
Query: 466 DLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD---------- 515
L + + + CDG+ + + ++ + + LNIP G+ WG +
Sbjct: 635 KLHESVEIECDGVQI--DLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSD 692
Query: 516 ------------FEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVL 556
F Q D LEV+G A+++G G RL QC VV+
Sbjct: 693 KRTTVTDAKELKFASQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCSCVVI 748
Query: 557 TTSKAIPVQVDGEP 570
TSK++P+Q+DGEP
Sbjct: 749 RTSKSLPMQIDGEP 762
>gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 279 bits (714), Expect = 7e-75
Identities = 185/569 (32%), Positives = 271/569 (47%), Gaps = 79/569 (13%)
Query: 62 GEHIWFETNVSGDFCYVGEQYCVARMLQKSVSRRK----CAACKIVVHTPCIEQLEKINF 117
G+H+W + YC + + S+ K C CK VH C
Sbjct: 204 GQHMWRPKR------FPRPVYC--NLCESSIGLGKQGLSCNLCKYTVHDQCA-------M 248
Query: 118 RCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWC 177
+ P + +++ ++ H WV + G+C C K + +HS + + C WC
Sbjct: 249 KALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIR---IYHS--LTGLHCVWC 303
Query: 178 KQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKS 237
H ++ LQ + C G+ ++PP+ I + L + +K + + S
Sbjct: 304 ----HLEIHDDCLQAVGHECDCGLLRDHILPPSSIY-----PSVLASGPDRKNS---KTS 351
Query: 238 SKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQ 297
K + +R P P PLLVFVNPKSGG QG +++ F + LNPRQVF+L +
Sbjct: 352 QKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLK 411
Query: 298 GGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTL 357
GP+ L +++ V + RIL CGGDGTVGWIL T+D+ L PPVA+LPLGTGNDLAR L
Sbjct: 412 DGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCL 471
Query: 358 NWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNY 417
WGGGY + ++KIL +E VV +DRW + P + E +D +P + NNY
Sbjct: 472 RWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIP-------QQTEEKSDPVPFQIINNY 524
Query: 418 FSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDG 477
FS+G DA + FH RE PEKFNSR +NK++Y A S+ + + K L + + V G
Sbjct: 525 FSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICG 584
Query: 478 MDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD----------------FEPQ-- 519
L + +L + + LNIP G+ WG H +P
Sbjct: 585 KPL--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDIL 642
Query: 520 -----RHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVLTTSKAIPVQVD 567
D LEV+G A+++G G RL +C E+ T+K +P+Q+D
Sbjct: 643 KTCVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQID 698
Query: 568 GEPCKLAASRIRIALRNQATMVQKAKRRS 596
GEP I+I +NQ M+ RS
Sbjct: 699 GEPWMQTPCTIKITHKNQMPMLMGPPPRS 727
>gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 279 bits (714), Expect = 7e-75
Identities = 185/569 (32%), Positives = 271/569 (47%), Gaps = 79/569 (13%)
Query: 62 GEHIWFETNVSGDFCYVGEQYCVARMLQKSVSRRK----CAACKIVVHTPCIEQLEKINF 117
G+H+W + YC + + S+ K C CK VH C
Sbjct: 204 GQHMWRPKR------FPRPVYC--NLCESSIGLGKQGLSCNLCKYTVHDQCA-------M 248
Query: 118 RCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWC 177
+ P + +++ ++ H WV + G+C C K + +HS + + C WC
Sbjct: 249 KALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIR---IYHS--LTGLHCVWC 303
Query: 178 KQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKS 237
H ++ LQ + C G+ ++PP+ I + L + +K + + S
Sbjct: 304 ----HLEIHDDCLQAVGHECDCGLLRDHILPPSSIY-----PSVLASGPDRKNS---KTS 351
Query: 238 SKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQ 297
K + +R P P PLLVFVNPKSGG QG +++ F + LNPRQVF+L +
Sbjct: 352 QKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLK 411
Query: 298 GGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTL 357
GP+ L +++ V + RIL CGGDGTVGWIL T+D+ L PPVA+LPLGTGNDLAR L
Sbjct: 412 DGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCL 471
Query: 358 NWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNY 417
WGGGY + ++KIL +E VV +DRW + P + E +D +P + NNY
Sbjct: 472 RWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIP-------QQTEEKSDPVPFQIINNY 524
Query: 418 FSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDG 477
FS+G DA + FH RE PEKFNSR +NK++Y A S+ + + K L + + V G
Sbjct: 525 FSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICG 584
Query: 478 MDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD----------------FEPQ-- 519
L + +L + + LNIP G+ WG H +P
Sbjct: 585 KPL--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDIL 642
Query: 520 -----RHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVLTTSKAIPVQVD 567
D LEV+G A+++G G RL +C E+ T+K +P+Q+D
Sbjct: 643 KTCVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQID 698
Query: 568 GEPCKLAASRIRIALRNQATMVQKAKRRS 596
GEP I+I +NQ M+ RS
Sbjct: 699 GEPWMQTPCTIKITHKNQMPMLMGPPPRS 727
>gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 279 bits (714), Expect = 7e-75
Identities = 185/569 (32%), Positives = 271/569 (47%), Gaps = 79/569 (13%)
Query: 62 GEHIWFETNVSGDFCYVGEQYCVARMLQKSVSRRK----CAACKIVVHTPCIEQLEKINF 117
G+H+W + YC + + S+ K C CK VH C
Sbjct: 204 GQHMWRPKR------FPRPVYC--NLCESSIGLGKQGLSCNLCKYTVHDQCA-------M 248
Query: 118 RCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWC 177
+ P + +++ ++ H WV + G+C C K + +HS + + C WC
Sbjct: 249 KALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIR---IYHS--LTGLHCVWC 303
Query: 178 KQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKS 237
H ++ LQ + C G+ ++PP+ I + L + +K + + S
Sbjct: 304 ----HLEIHDDCLQAVGHECDCGLLRDHILPPSSIY-----PSVLASGPDRKNS---KTS 351
Query: 238 SKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQ 297
K + +R P P PLLVFVNPKSGG QG +++ F + LNPRQVF+L +
Sbjct: 352 QKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLK 411
Query: 298 GGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTL 357
GP+ L +++ V + RIL CGGDGTVGWIL T+D+ L PPVA+LPLGTGNDLAR L
Sbjct: 412 DGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCL 471
Query: 358 NWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNY 417
WGGGY + ++KIL +E VV +DRW + P + E +D +P + NNY
Sbjct: 472 RWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIP-------QQTEEKSDPVPFQIINNY 524
Query: 418 FSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDG 477
FS+G DA + FH RE PEKFNSR +NK++Y A S+ + + K L + + V G
Sbjct: 525 FSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICG 584
Query: 478 MDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD----------------FEPQ-- 519
L + +L + + LNIP G+ WG H +P
Sbjct: 585 KPL--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDIL 642
Query: 520 -----RHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVLTTSKAIPVQVD 567
D LEV+G A+++G G RL +C E+ T+K +P+Q+D
Sbjct: 643 KTCVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQID 698
Query: 568 GEPCKLAASRIRIALRNQATMVQKAKRRS 596
GEP I+I +NQ M+ RS
Sbjct: 699 GEPWMQTPCTIKITHKNQMPMLMGPPPRS 727
>gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 279 bits (714), Expect = 7e-75
Identities = 185/569 (32%), Positives = 271/569 (47%), Gaps = 79/569 (13%)
Query: 62 GEHIWFETNVSGDFCYVGEQYCVARMLQKSVSRRK----CAACKIVVHTPCIEQLEKINF 117
G+H+W + YC + + S+ K C CK VH C
Sbjct: 204 GQHMWRPKR------FPRPVYC--NLCESSIGLGKQGLSCNLCKYTVHDQCA-------M 248
Query: 118 RCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWC 177
+ P + +++ ++ H WV + G+C C K + +HS + + C WC
Sbjct: 249 KALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIR---IYHS--LTGLHCVWC 303
Query: 178 KQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKS 237
H ++ LQ + C G+ ++PP+ I + L + +K + + S
Sbjct: 304 ----HLEIHDDCLQAVGHECDCGLLRDHILPPSSIY-----PSVLASGPDRKNS---KTS 351
Query: 238 SKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQ 297
K + +R P P PLLVFVNPKSGG QG +++ F + LNPRQVF+L +
Sbjct: 352 QKTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLK 411
Query: 298 GGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTL 357
GP+ L +++ V + RIL CGGDGTVGWIL T+D+ L PPVA+LPLGTGNDLAR L
Sbjct: 412 DGPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCL 471
Query: 358 NWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNY 417
WGGGY + ++KIL +E VV +DRW + P + E +D +P + NNY
Sbjct: 472 RWGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIP-------QQTEEKSDPVPFQIINNY 524
Query: 418 FSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDG 477
FS+G DA + FH RE PEKFNSR +NK++Y A S+ + + K L + + V G
Sbjct: 525 FSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICG 584
Query: 478 MDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHD----------------FEPQ-- 519
L + +L + + LNIP G+ WG H +P
Sbjct: 585 KPL--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDIL 642
Query: 520 -----RHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVLTTSKAIPVQVD 567
D LEV+G A+++G G RL +C E+ T+K +P+Q+D
Sbjct: 643 KTCVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQID 698
Query: 568 GEPCKLAASRIRIALRNQATMVQKAKRRS 596
GEP I+I +NQ M+ RS
Sbjct: 699 GEPWMQTPCTIKITHKNQMPMLMGPPPRS 727
>gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens]
Length = 752
Score = 270 bits (689), Expect = 6e-72
Identities = 149/365 (40%), Positives = 204/365 (55%), Gaps = 36/365 (9%)
Query: 256 PSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRI 315
P+P PLLV VNPKSGG QG +I++ F + LNP+QVF+L GGP L +R + R+
Sbjct: 389 PTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRV 448
Query: 316 LACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHV 375
LACGGDGTVGWIL +D+ PPVA+LPLGTGNDLAR L WGGGY ++KIL +
Sbjct: 449 LACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDI 508
Query: 376 EEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESRE 435
E+ +V LDRW L P E+ + G D++P + NNYFS+G DA + FH RE
Sbjct: 509 EQSPLVMLDRWHLEVIPR-----EEVENG--DQVPYSIMNNYFSIGVDASIAHRFHVMRE 561
Query: 436 ANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFL 495
+PEKFNSR +NK++Y S+ + K L HI + CDG+ + + ++ + + L
Sbjct: 562 KHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGV--DLSNIFLEGIAIL 619
Query: 496 NIPRYCAGTMPWGHPGEHH----------------DFEPQRHDDGYLEVIGFTMTSLAAL 539
NIP GT WG ++ F Q D LEV+G A+
Sbjct: 620 NIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLE----GAM 675
Query: 540 QVG-------GHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKA 592
++G G RL QC V + T+K +P+QVDGEP I+I +NQA M+
Sbjct: 676 EMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGP 735
Query: 593 KRRSA 597
++S+
Sbjct: 736 PQKSS 740
>gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens]
Length = 766
Score = 249 bits (637), Expect = 6e-66
Identities = 182/572 (31%), Positives = 257/572 (44%), Gaps = 105/572 (18%)
Query: 53 VDWSESATYGEHIW----FETNVSGDFCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPC 108
+D S S G H W F+ +FC++ ++ C CK VH C
Sbjct: 261 MDDSGSKGDGRHAWTMKHFKKPTYCNFCHI-------MLMGVRKQGLCCTYCKYTVHERC 313
Query: 109 IEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKE 168
+ R P ++ S+ R ++H WV KC C K + +
Sbjct: 314 VS-------RNIPGCVKTYSKAKRSGEVMQHAWVEGN-SSVKCDRCHKSIKCY-----QS 360
Query: 169 IVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKK 228
+ A C WC+ +H K ++ C G ++ PT I R + K+
Sbjct: 361 VTARHCVWCRMTFHRKC------ELSTLCDGGELRDHILLPTSICPITRDRPGEKSD--- 411
Query: 229 KRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLN 288
S KG +++ I PTP PLLV VNPKSGG QG
Sbjct: 412 ------GCVSAKGELVMQYK---IIPTPG--THPLLVLVNPKSGGRQG------------ 448
Query: 289 PRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLG 348
E L +R + R+LACGGDGTVGWIL +D+ PPVA+LPLG
Sbjct: 449 -------------ERLNFFRDTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLG 495
Query: 349 TGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDR 408
TGNDLAR L WGGGY ++KIL +E+ +V LDRW L P E+ + G D+
Sbjct: 496 TGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVIPR-----EEVENG--DQ 548
Query: 409 LPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLA 468
+P + NNYFS+G DA + FH RE +PEKFNSR +NK++Y S+ + K L
Sbjct: 549 VPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLH 608
Query: 469 KHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHH-------------- 514
HI + CDG+ + + ++ + + LNIP GT WG ++
Sbjct: 609 DHIELECDGVGV--DLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPK 666
Query: 515 --DFEPQRHDDGYLEVIGFTMTSLAALQVG-------GHGERLTQCREVVLTTSKAIPVQ 565
F Q D LEV+G A+++G G RL QC V + T+K +P+Q
Sbjct: 667 ELKFCVQDLSDQLLEVVGLE----GAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQ 722
Query: 566 VDGEPCKLAASRIRIALRNQATMVQKAKRRSA 597
VDGEP I+I +NQA M+ ++S+
Sbjct: 723 VDGEPWMQPCCTIKITHKNQAPMMMGPPQKSS 754
>gi|40806175 diacylglycerol kinase, theta [Homo sapiens]
Length = 942
Score = 238 bits (606), Expect = 2e-62
Identities = 147/373 (39%), Positives = 205/373 (54%), Gaps = 21/373 (5%)
Query: 249 PFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYR 308
P ++ P PLLVFVNPKSGG +G ++ SF LNP QVFDL+ GGP L ++
Sbjct: 575 PDLLHAKLPPDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFS 634
Query: 309 KVHNLRILACGGDGTVGWILSTLDQLRLK---PPPPVAILPLGTGNDLARTLNWGGGYTD 365
+V R+L CGGDGTVGW+L L++ R + P P VAILPLGTGNDL R L WG GY+
Sbjct: 635 QVPCFRVLVCGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSG 694
Query: 366 EPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAH 425
E +L V+E + V +DRW + + + EAG + D + + +NY +G DA
Sbjct: 695 EDPFSVLLSVDEADAVLMDRWTILLDAH-EAGSAENDTADAEPPKIVQMSNYCGIGIDAE 753
Query: 426 VTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDL-TPKI 484
++L+FH++RE P KF SR NK Y + S+ L K IR+ + ++ P I
Sbjct: 754 LSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQK--ISHSRSLHKQIRLQVERQEVELPSI 811
Query: 485 QDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFT-MTSLAALQVG- 542
+ L +F+NIP + +G WG + FE R DDG LEV+G T + + +Q G
Sbjct: 812 EGL-----IFINIPSWGSGADLWGSDSDTR-FEKPRMDDGLLEVVGVTGVVHMGQVQGGL 865
Query: 543 GHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRI-ALRNQATMVQKAKRR-----S 596
G R+ Q +T KA PVQVDGEP A + I A + M++KAK++ +
Sbjct: 866 RSGIRIAQGSYFRVTLLKATPVQVDGEPWVQAPGHMIISAAGPKVHMLRKAKQKPRRAGT 925
Query: 597 AAPLHSDQQPVPE 609
+D P PE
Sbjct: 926 TRDARADAAPAPE 938
>gi|4503313 diacylglycerol kinase epsilon [Homo sapiens]
Length = 567
Score = 217 bits (553), Expect = 3e-56
Identities = 164/542 (30%), Positives = 262/542 (48%), Gaps = 72/542 (13%)
Query: 63 EHIWFETNVSGD--FCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCK 120
+H W +T++ +C V C +LQ + C C + V C+ + +K F+CK
Sbjct: 59 KHGWRDTDLFSQPTYCCV----CAQHILQGAF----CDCCGLRVDEGCLRKADK-RFQCK 109
Query: 121 PSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQA 180
++ ++ + + HHW+ R C +C QQ ++ C WC++
Sbjct: 110 EIMLKNDTKVLDA---MPHHWI--RGNVPLCSYCMVCKQQCGC--QPKLCDYRCIWCQKT 162
Query: 181 YHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRKSSKK 240
H + C E C G ++IPP+++ ++ +K K+ ++ +SK
Sbjct: 163 VHDE--CMKNSLKNEKCDFGEFKNLIIPPSYL-------TSINQMRKDKKTDYEVLASKL 213
Query: 241 GPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGP 300
G + W P L++ N +SG N G ++ F LNP QVFD+++ P
Sbjct: 214 GKQ---WTP-------------LIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPP 257
Query: 301 KEALEMYRKV--HNLRILACGGDGTVGWILSTLDQLRLKPP----PPVAILPLGTGNDLA 354
+AL++ + ++ R+L CGGDGTVGW+L +D +++K P VA+LPLGTGNDL+
Sbjct: 258 IKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLS 317
Query: 355 RTLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATD-RLPLD 412
TL WG GY E PV+++L +V E + ++LDRW + ++G + R P +
Sbjct: 318 NTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVT----------NKGYYNLRKPKE 367
Query: 413 -VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHI 471
NNYFS+G DA + L FH RE P F+SR NK Y D L+ KDL K +
Sbjct: 368 FTMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKV 427
Query: 472 RVVCDGMDLT-PKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIG 530
+ DG + P ++ ++ LNI + G W G+ + RHDDG LEV+G
Sbjct: 428 ELELDGERVALPSLEG-----IIVLNIGYWGGGCRLWEGMGD-ETYPLARHDDGLLEVVG 481
Query: 531 -FTMTSLAALQVG-GHGERLTQCREV-VLTTSKAIPVQVDGEPCKLAASRIRIALRNQAT 587
+ A +QV + R+ Q V ++ +P+QVDGEP + I + A
Sbjct: 482 VYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHAM 541
Query: 588 MV 589
M+
Sbjct: 542 ML 543
>gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens]
Length = 1164
Score = 152 bits (384), Expect = 1e-36
Identities = 108/334 (32%), Positives = 146/334 (43%), Gaps = 55/334 (16%)
Query: 62 GEHIWFE-TNVSGDFCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCK 120
G H W+ ++ FC V C + + C CK H C + CK
Sbjct: 174 GMHNWYACSHARPTFCNV----CRESLSGVTSHGLSCEVCKFKAHKRCAVRATN---NCK 226
Query: 121 PSFRESGSRNVREP---TFVRHHWVHRRRQ-DGKCRHCGKGFQQKFTFHSKEIVAISCSW 176
+ S +++ E + H W+ KC C K + C W
Sbjct: 227 WTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWK-----CLW 281
Query: 177 CKQAYHSKVSCFMLQQIEEP-CSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKR 235
CK H+ +C + + P C LG +IPP +
Sbjct: 282 CKTMVHT--AC---KDLYHPICPLGQCKVSIIPPIAL----------------------N 314
Query: 236 KSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDL 295
+ G R T S + PLLVFVN KSG NQG K ++ F LNP QVFDL
Sbjct: 315 STDSDG---------FCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDL 365
Query: 296 SQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLAR 355
GGP L +++K N RIL CGGDG+VGW+LS +D+L L + +LPLGTGNDLAR
Sbjct: 366 MNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLAR 425
Query: 356 TLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDL 388
L WGG Y D+ + +IL +E + LDRW +
Sbjct: 426 VLGWGGSYDDDTQLPQILEKLERASTKMLDRWSI 459
Score = 105 bits (262), Expect = 2e-22
Identities = 65/184 (35%), Positives = 94/184 (51%), Gaps = 10/184 (5%)
Query: 413 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 472
V NNYF +G DA ++LEF+ RE +PEK SR +N M+Y + L S K+L + ++
Sbjct: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
Query: 473 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 531
+ CDG + P +Q + LNIP Y GT WG E F DD LEV+
Sbjct: 830 LECDGQYIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAI 884
Query: 532 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQAT 587
+M + + R+ QCR V +T + +PVQVDGE I+I +N+A
Sbjct: 885 FDSMQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQ 944
Query: 588 MVQK 591
M+ +
Sbjct: 945 MLTR 948
>gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]
Length = 1220
Score = 152 bits (384), Expect = 1e-36
Identities = 108/334 (32%), Positives = 146/334 (43%), Gaps = 55/334 (16%)
Query: 62 GEHIWFE-TNVSGDFCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCK 120
G H W+ ++ FC V C + + C CK H C + CK
Sbjct: 174 GMHNWYACSHARPTFCNV----CRESLSGVTSHGLSCEVCKFKAHKRCAVRATN---NCK 226
Query: 121 PSFRESGSRNVREP---TFVRHHWVHRRRQ-DGKCRHCGKGFQQKFTFHSKEIVAISCSW 176
+ S +++ E + H W+ KC C K + C W
Sbjct: 227 WTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWK-----CLW 281
Query: 177 CKQAYHSKVSCFMLQQIEEP-CSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKR 235
CK H+ +C + + P C LG +IPP +
Sbjct: 282 CKTMVHT--AC---KDLYHPICPLGQCKVSIIPPIAL----------------------N 314
Query: 236 KSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDL 295
+ G R T S + PLLVFVN KSG NQG K ++ F LNP QVFDL
Sbjct: 315 STDSDG---------FCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDL 365
Query: 296 SQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLAR 355
GGP L +++K N RIL CGGDG+VGW+LS +D+L L + +LPLGTGNDLAR
Sbjct: 366 MNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLAR 425
Query: 356 TLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDL 388
L WGG Y D+ + +IL +E + LDRW +
Sbjct: 426 VLGWGGSYDDDTQLPQILEKLERASTKMLDRWSI 459
Score = 105 bits (262), Expect = 2e-22
Identities = 65/184 (35%), Positives = 94/184 (51%), Gaps = 10/184 (5%)
Query: 413 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 472
V NNYF +G DA ++LEF+ RE +PEK SR +N M+Y + L S K+L + ++
Sbjct: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
Query: 473 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 531
+ CDG + P +Q + LNIP Y GT WG E F DD LEV+
Sbjct: 830 LECDGQYIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAI 884
Query: 532 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQAT 587
+M + + R+ QCR V +T + +PVQVDGE I+I +N+A
Sbjct: 885 FDSMQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQ 944
Query: 588 MVQK 591
M+ +
Sbjct: 945 MLTR 948
>gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo
sapiens]
Length = 1170
Score = 151 bits (381), Expect = 3e-36
Identities = 108/337 (32%), Positives = 145/337 (43%), Gaps = 56/337 (16%)
Query: 62 GEHIWFETNVSGDFCYVGEQYC-VARMLQKSVSRR--KCAACKIVVHTPCIEQLEKINFR 118
G H W+ + + YC V R V+ C CK H C +
Sbjct: 118 GMHNWYACS------HARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATN---N 168
Query: 119 CKPSFRESGSRNVREPT---FVRHHWVHRRRQ-DGKCRHCGKGFQQKFTFHSKEIVAISC 174
CK + S +++ E + H W+ KC C K C
Sbjct: 169 CKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWR-----C 223
Query: 175 SWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFK 234
WCK H+ +L + C LG+ VIPPT + N++ +
Sbjct: 224 LWCKAMVHTSCKESLLTK----CPLGLCKVSVIPPTAL-------NSIDS---------- 262
Query: 235 RKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFD 294
+G W+ P PLLVFVN KSG NQG K ++ F LNP QVFD
Sbjct: 263 ---------DGFWKA----SCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFD 309
Query: 295 LSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLA 354
L GGP L +++K RIL CGGDG+VGW+LS +D L L + +LPLGTGNDLA
Sbjct: 310 LMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLA 369
Query: 355 RTLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDLHA 390
R L WG D+ + +IL +E + LDRW + A
Sbjct: 370 RVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMA 406
Score = 99.4 bits (246), Expect = 1e-20
Identities = 78/279 (27%), Positives = 124/279 (44%), Gaps = 25/279 (8%)
Query: 413 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 472
V NNYF +G DA ++L+F+ R+ +PEK SR +N M+Y + L + K+L + +
Sbjct: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
Query: 473 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 531
+ CDG + P +Q + LNIP Y GT WG E F DD LEV+
Sbjct: 779 LECDGRPIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAV 833
Query: 532 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQA- 586
+M + + R+ QCR V ++ + +PVQVDGE IRI +N+A
Sbjct: 834 FGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQ 893
Query: 587 TMVQKAKRRSAAPLHSDQQ----PVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGT 642
T+ + S D+Q P P S+H + Q+ + G
Sbjct: 894 TLTRDRAFESTLKSWEDKQKCELPRPPS-------CSLHPEMLSEEEATQMDQFGQAAGV 946
Query: 643 VVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPK 681
++ S E+ ++H + Q+ A S + ++ K
Sbjct: 947 LI---HSIREIAQSHRDMEQELAHAVNASSKSMDRVYGK 982
>gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo
sapiens]
Length = 1214
Score = 151 bits (381), Expect = 3e-36
Identities = 108/337 (32%), Positives = 145/337 (43%), Gaps = 56/337 (16%)
Query: 62 GEHIWFETNVSGDFCYVGEQYC-VARMLQKSVSRR--KCAACKIVVHTPCIEQLEKINFR 118
G H W+ + + YC V R V+ C CK H C +
Sbjct: 162 GMHNWYACS------HARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATN---N 212
Query: 119 CKPSFRESGSRNVREPT---FVRHHWVHRRRQ-DGKCRHCGKGFQQKFTFHSKEIVAISC 174
CK + S +++ E + H W+ KC C K C
Sbjct: 213 CKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWR-----C 267
Query: 175 SWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFK 234
WCK H+ +L + C LG+ VIPPT + N++ +
Sbjct: 268 LWCKAMVHTSCKESLLTK----CPLGLCKVSVIPPTAL-------NSIDS---------- 306
Query: 235 RKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFD 294
+G W+ P PLLVFVN KSG NQG K ++ F LNP QVFD
Sbjct: 307 ---------DGFWKA----SCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFD 353
Query: 295 LSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLA 354
L GGP L +++K RIL CGGDG+VGW+LS +D L L + +LPLGTGNDLA
Sbjct: 354 LMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLA 413
Query: 355 RTLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDLHA 390
R L WG D+ + +IL +E + LDRW + A
Sbjct: 414 RVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMA 450
Score = 99.4 bits (246), Expect = 1e-20
Identities = 78/279 (27%), Positives = 124/279 (44%), Gaps = 25/279 (8%)
Query: 413 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 472
V NNYF +G DA ++L+F+ R+ +PEK SR +N M+Y + L + K+L + +
Sbjct: 763 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 822
Query: 473 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 531
+ CDG + P +Q + LNIP Y GT WG E F DD LEV+
Sbjct: 823 LECDGRPIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAV 877
Query: 532 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQA- 586
+M + + R+ QCR V ++ + +PVQVDGE IRI +N+A
Sbjct: 878 FGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQ 937
Query: 587 TMVQKAKRRSAAPLHSDQQ----PVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGT 642
T+ + S D+Q P P S+H + Q+ + G
Sbjct: 938 TLTRDRAFESTLKSWEDKQKCELPRPPS-------CSLHPEMLSEEEATQMDQFGQAAGV 990
Query: 643 VVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPK 681
++ S E+ ++H + Q+ A S + ++ K
Sbjct: 991 LI---HSIREIAQSHRDMEQELAHAVNASSKSMDRVYGK 1026
>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
Length = 1271
Score = 134 bits (337), Expect = 4e-31
Identities = 101/346 (29%), Positives = 143/346 (41%), Gaps = 52/346 (15%)
Query: 62 GEHIWFETNVSGDFCYVGEQYCVARMLQKSVSRRK--CAACKIVVHTPCIEQLEKINFRC 119
G H W+ + + + + V R ++SR C CK+ H C + K C
Sbjct: 326 GMHCWYSS-----YSHRTQHCNVCRESIPALSRDAIICEVCKVKSHRLCALRASK---DC 377
Query: 120 KPSFRESGSRNVREPTFVR--HHWVHRRR----QDGKCRHCGKGFQQKFTFHSKEIVAIS 173
K + + V H WV Q C +Q+ F
Sbjct: 378 KWNTLSITDDLLLPADEVNMPHQWVEGNMPVSSQCAVCHESCGSYQRLQDFR-------- 429
Query: 174 CSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASF 233
C WC H ++ + C H + VIPPT + + + +S
Sbjct: 430 CLWCNSTVHDDCR----RRFSKECCFRSHRSSVIPPTALSDPKGDGQLVVSSD------- 478
Query: 234 KRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVF 293
F S PLL+F+N KSG +QG ++ F YLNP QVF
Sbjct: 479 ----------------FWNLDWSSACSCPLLIFINSKSGDHQGIVFLRKFKQYLNPSQVF 522
Query: 294 DLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDL 353
DL +GGP+ L M++ RIL CGGDG+V W+LS +D L +A++PLGTGNDL
Sbjct: 523 DLLKGGPEAGLSMFKNFARFRILVCGGDGSVSWVLSLIDAFGLHEKCQLAVIPLGTGNDL 582
Query: 354 ARTLNWGGGYT-DEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGP 398
AR L WG + + IL+ VE+ +V LDRW + P P
Sbjct: 583 ARVLGWGAFWNKSKSPLDILNRVEQASVRILDRWSVMIRETPRQTP 628
Score = 110 bits (275), Expect = 6e-24
Identities = 73/223 (32%), Positives = 114/223 (51%), Gaps = 16/223 (7%)
Query: 413 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 472
V NNYF +G DA ++L+F+ R+ +P ++NSR +NKM+Y + L S + L + +
Sbjct: 857 VMNNYFGIGLDAKISLDFNTRRDEHPGQYNSRLKNKMWYGLLGTKELLQRSYRKLEERVH 916
Query: 473 VVCDGMDLT-PKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 531
+ CDG ++ P +Q +V LNI Y G WG ++E DDG LEV+
Sbjct: 917 LECDGETISLPNLQG-----IVVLNITSYAGGINFWGSNTATTEYEAPAIDDGKLEVVAI 971
Query: 532 TMTSLAALQ--VGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQAT 587
+ A+ + H R+ QC EV++T + IPVQVDGE I+I +N A
Sbjct: 972 FGSVQMAMSRIINLHHHRIAQCHEVMITIDGEEGIPVQVDGEAWIQRPGLIKIRYKNAAQ 1031
Query: 588 MVQKAK-----RRSAAPLHSDQQPVPE-QLRIQVSRVSMHDYE 624
M+ + + + H++ Q P+ QL Q S+ S+ D E
Sbjct: 1032 MLTRDRDFENSMKMWEYKHTEIQAAPQPQLDFQDSQESLSDEE 1074
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 57.4 bits (137), Expect = 6e-08
Identities = 41/117 (35%), Positives = 54/117 (46%), Gaps = 2/117 (1%)
Query: 761 LIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDA 820
L++A R + +L R G + RD RT LH AV G +VR LL P + A
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAP--VGA 102
Query: 821 VEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYL 877
V+ G T LH+AA G + +++ GAS G TP A T LAA L
Sbjct: 103 VDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARL 159
Score = 43.5 bits (101), Expect = 9e-04
Identities = 38/121 (31%), Positives = 51/121 (42%), Gaps = 4/121 (3%)
Query: 761 LIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDH-APPEILD 819
L+ AA L+ L G + RD T L A + G + LL H A P I D
Sbjct: 207 LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
Query: 820 AVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLEN 879
+G + LH+AAA G +V GA + D G TP A + E+A L +
Sbjct: 267 ---RHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLD 323
Query: 880 R 880
R
Sbjct: 324 R 324
Score = 32.3 bits (72), Expect = 2.0
Identities = 24/82 (29%), Positives = 36/82 (43%), Gaps = 2/82 (2%)
Query: 780 GGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRT 839
G D RD R+ LH A + G V+ L+ +DA + G T LH A+ G
Sbjct: 259 GADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAE--VDARDTLGLTPLHHASREGHVE 316
Query: 840 ICHYIVEAGASLMKTDQQGDTP 861
+ +++ GA + T TP
Sbjct: 317 VAGCLLDRGAQVDATGWLRKTP 338
>gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
Length = 300
Score = 53.5 bits (127), Expect = 8e-07
Identities = 36/109 (33%), Positives = 53/109 (48%), Gaps = 4/109 (3%)
Query: 759 EELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDH-APPEI 817
+ L ++A ND +Q+L G D D++ RT LH A G+ +V+ LLDH A P
Sbjct: 112 KRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQ 171
Query: 818 LDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAE 866
D + G T LH AA + ++ GA + D+ G TP A+
Sbjct: 172 RDGL---GNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAK 217
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 53.1 bits (126), Expect = 1e-06
Identities = 36/114 (31%), Positives = 55/114 (48%), Gaps = 2/114 (1%)
Query: 764 AAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEE 823
AA++ + ++ L G D+ D+Q RT L A G V +LL L ++++
Sbjct: 1111 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAA--LSSLDK 1168
Query: 824 NGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYL 877
G + L A G R + Y+VE GA++ +TD+ G TP A D E YL
Sbjct: 1169 EGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYL 1222
Score = 46.6 bits (109), Expect = 1e-04
Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 2/117 (1%)
Query: 761 LIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDA 820
L+ AA ++ L G L D++ + L A G + VV+YL++ +D
Sbjct: 1141 LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAA--IDQ 1198
Query: 821 VEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYL 877
++NG T L AA G Y+VE GA + D G P RA ++T + L
Sbjct: 1199 TDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVAL 1255
Score = 32.0 bits (71), Expect = 2.6
Identities = 31/129 (24%), Positives = 51/129 (39%), Gaps = 43/129 (33%)
Query: 776 LHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLL----------------DHAPPEILD 819
L + G + H D++ + L H+ G D+++YLL HA + L
Sbjct: 979 LTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALT 1038
Query: 820 A---------------------VEENG------ETCLHQAAALGQRTICHYIVEAGASLM 852
A VE NG ET L AA G+ +C ++ GA++
Sbjct: 1039 AAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVS 1098
Query: 853 KTDQQGDTP 861
+T+++G P
Sbjct: 1099 RTNRRGVPP 1107
Score = 30.4 bits (67), Expect = 7.7
Identities = 19/58 (32%), Positives = 28/58 (48%), Gaps = 2/58 (3%)
Query: 801 GSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQG 858
G ++VV LL+ LD ENG T L AAA G + + + G + D++G
Sbjct: 938 GHEEVVTLLLEFGA--CLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKG 993
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 53.1 bits (126), Expect = 1e-06
Identities = 36/114 (31%), Positives = 55/114 (48%), Gaps = 2/114 (1%)
Query: 764 AAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEE 823
AA++ + ++ L G D+ D+Q RT L A G V +LL L ++++
Sbjct: 1119 AARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAA--LSSLDK 1176
Query: 824 NGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYL 877
G + L A G R + Y+VE GA++ +TD+ G TP A D E YL
Sbjct: 1177 EGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYL 1230
Score = 46.6 bits (109), Expect = 1e-04
Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 2/117 (1%)
Query: 761 LIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDA 820
L+ AA ++ L G L D++ + L A G + VV+YL++ +D
Sbjct: 1149 LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAA--IDQ 1206
Query: 821 VEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYL 877
++NG T L AA G Y+VE GA + D G P RA ++T + L
Sbjct: 1207 TDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVAL 1263
Score = 32.0 bits (71), Expect = 2.6
Identities = 31/129 (24%), Positives = 51/129 (39%), Gaps = 43/129 (33%)
Query: 776 LHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLL----------------DHAPPEILD 819
L + G + H D++ + L H+ G D+++YLL HA + L
Sbjct: 987 LTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALT 1046
Query: 820 A---------------------VEENG------ETCLHQAAALGQRTICHYIVEAGASLM 852
A VE NG ET L AA G+ +C ++ GA++
Sbjct: 1047 AAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVS 1106
Query: 853 KTDQQGDTP 861
+T+++G P
Sbjct: 1107 RTNRRGVPP 1115
Score = 30.4 bits (67), Expect = 7.7
Identities = 19/58 (32%), Positives = 28/58 (48%), Gaps = 2/58 (3%)
Query: 801 GSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQG 858
G ++VV LL+ LD ENG T L AAA G + + + G + D++G
Sbjct: 946 GHEEVVTLLLEFGA--CLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKG 1001
>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 50.8 bits (120), Expect = 5e-06
Identities = 33/124 (26%), Positives = 58/124 (46%), Gaps = 2/124 (1%)
Query: 758 GEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEI 817
G + A D ++ +L G D+ + + T LH A + D+V++L+++
Sbjct: 41 GAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGAN-- 98
Query: 818 LDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYL 877
++ + G LH AA+ G I +++ GA + + +GDTP AE+ EL
Sbjct: 99 INQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNE 158
Query: 878 ENRQ 881
NRQ
Sbjct: 159 VNRQ 162
Score = 33.5 bits (75), Expect = 0.91
Identities = 33/140 (23%), Positives = 62/140 (44%), Gaps = 12/140 (8%)
Query: 757 QGEELIEAAKRNDFCKLQELHR---AG--GDLMHRDEQSRTLLHHAVSTGSKDVVRYLLD 811
QG ++ A K + L++ + +G D+ H + T LH A + G +V++ L+
Sbjct: 162 QGVDIEAARKEEERIMLRDARQWLNSGHINDVRHA-KSGGTALHVAAAKGYTEVLKLLIQ 220
Query: 812 HAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDT 871
++ + +G T LH AA G+ C +V+ + ++ G T A D
Sbjct: 221 AGYD--VNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT----AFDVADE 274
Query: 872 ELAAYLENRQHYQMIQREDQ 891
++ YLE Q Q + ++
Sbjct: 275 DILGYLEELQKKQNLLHSEK 294
Score = 32.0 bits (71), Expect = 2.6
Identities = 31/111 (27%), Positives = 50/111 (45%), Gaps = 23/111 (20%)
Query: 759 EELIEAAKRNDFCKLQELHRAGGDL-MHRDEQSRTLLHHA---VSTGSKDVVRYLLDHAP 814
EE +E +N E++R G D+ R E+ R +L A +++G + VR+
Sbjct: 148 EEAMEELLQN------EVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHA----- 196
Query: 815 PEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRA 865
++G T LH AAA G + +++AG + D G TP A
Sbjct: 197 --------KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAA 239
>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 50.8 bits (120), Expect = 5e-06
Identities = 33/124 (26%), Positives = 58/124 (46%), Gaps = 2/124 (1%)
Query: 758 GEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEI 817
G + A D ++ +L G D+ + + T LH A + D+V++L+++
Sbjct: 41 GAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGAN-- 98
Query: 818 LDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYL 877
++ + G LH AA+ G I +++ GA + + +GDTP AE+ EL
Sbjct: 99 INQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNE 158
Query: 878 ENRQ 881
NRQ
Sbjct: 159 VNRQ 162
Score = 33.5 bits (75), Expect = 0.91
Identities = 33/140 (23%), Positives = 62/140 (44%), Gaps = 12/140 (8%)
Query: 757 QGEELIEAAKRNDFCKLQELHR---AG--GDLMHRDEQSRTLLHHAVSTGSKDVVRYLLD 811
QG ++ A K + L++ + +G D+ H + T LH A + G +V++ L+
Sbjct: 162 QGVDIEAARKEEERIMLRDARQWLNSGHINDVRHA-KSGGTALHVAAAKGYTEVLKLLIQ 220
Query: 812 HAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDT 871
++ + +G T LH AA G+ C +V+ + ++ G T A D
Sbjct: 221 AGYD--VNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT----AFDVADE 274
Query: 872 ELAAYLENRQHYQMIQREDQ 891
++ YLE Q Q + ++
Sbjct: 275 DILGYLEELQKKQNLLHSEK 294
Score = 32.0 bits (71), Expect = 2.6
Identities = 31/111 (27%), Positives = 50/111 (45%), Gaps = 23/111 (20%)
Query: 759 EELIEAAKRNDFCKLQELHRAGGDL-MHRDEQSRTLLHHA---VSTGSKDVVRYLLDHAP 814
EE +E +N E++R G D+ R E+ R +L A +++G + VR+
Sbjct: 148 EEAMEELLQN------EVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHA----- 196
Query: 815 PEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRA 865
++G T LH AAA G + +++AG + D G TP A
Sbjct: 197 --------KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAA 239
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 50.4 bits (119), Expect = 7e-06
Identities = 43/155 (27%), Positives = 72/155 (46%), Gaps = 11/155 (7%)
Query: 721 LLGASARPDLP--TPTSPLPTSPC---SPTPRSLQGDAAPPQGEE----LIEAAKRNDFC 771
L+ +AR + P TP P T+P +P+ S Q D + E L AA R D
Sbjct: 117 LMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVK 176
Query: 772 KLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQ 831
+++EL G ++ +D T LH A + G DV + L+ +++ +T LH
Sbjct: 177 QVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDD--DTPLHD 234
Query: 832 AAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAE 866
+A+ G R I ++ G + + ++ G+ P AE
Sbjct: 235 SASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAE 269
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 50.4 bits (119), Expect = 7e-06
Identities = 43/155 (27%), Positives = 72/155 (46%), Gaps = 11/155 (7%)
Query: 721 LLGASARPDLP--TPTSPLPTSPC---SPTPRSLQGDAAPPQGEE----LIEAAKRNDFC 771
L+ +AR + P TP P T+P +P+ S Q D + E L AA R D
Sbjct: 140 LMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVK 199
Query: 772 KLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQ 831
+++EL G ++ +D T LH A + G DV + L+ +++ +T LH
Sbjct: 200 QVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDD--DTPLHD 257
Query: 832 AAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAE 866
+A+ G R I ++ G + + ++ G+ P AE
Sbjct: 258 SASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAE 292
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 50.4 bits (119), Expect = 7e-06
Identities = 41/131 (31%), Positives = 65/131 (49%), Gaps = 11/131 (8%)
Query: 749 LQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSR--TLLHHAVSTGSKDVV 806
L+GDAA L++AAK+ ++Q+L ++ RD Q R T LH A + +V
Sbjct: 801 LRGDAA------LLDAAKKGCLARVQKLCTPE-NINCRDTQGRNSTPLHLAAGYNNLEVA 853
Query: 807 RYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAE 866
YLL+H ++A ++ G LH AA+ G I +++ + TD+ TP A
Sbjct: 854 EYLLEHGAD--VNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAA 911
Query: 867 KAQDTELAAYL 877
+ T+L A L
Sbjct: 912 QKGRTQLCALL 922
Score = 48.1 bits (113), Expect = 4e-05
Identities = 50/177 (28%), Positives = 80/177 (45%), Gaps = 12/177 (6%)
Query: 697 DRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDAAPP 756
+ Q+ L+ T I ++ D LL AS DL T + + R L+G + P
Sbjct: 633 EAVQQILSESTPIRTSDV---DYRLLEASKAGDLETVKQLCSSQ--NVNCRDLEGRHSTP 687
Query: 757 QGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPE 816
L AA N ++ L G D+ +D+ LH+A S G +V L+ H
Sbjct: 688 ----LHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGAS- 742
Query: 817 ILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTEL 873
++ + T LH+AAA G+ IC +++ GA K ++ G+TP K DT++
Sbjct: 743 -VNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTDI 797
Score = 42.4 bits (98), Expect = 0.002
Identities = 33/115 (28%), Positives = 54/115 (46%), Gaps = 6/115 (5%)
Query: 747 RSLQGDAAPPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVV 806
R QG + P L AA N+ + L G D+ +D+ LH+A S G D+
Sbjct: 831 RDTQGRNSTP----LHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIA 886
Query: 807 RYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTP 861
L+ + ++A ++ T LH+AA G+ +C ++ GA +Q+G TP
Sbjct: 887 ALLIKYNT--CVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTP 939
Score = 40.8 bits (94), Expect = 0.006
Identities = 26/93 (27%), Positives = 42/93 (45%), Gaps = 2/93 (2%)
Query: 776 LHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAAL 835
L R G ++ +++ T LH A DV+ L H ++A++ G+T LH+AA
Sbjct: 544 LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK--MNALDTLGQTALHRAALA 601
Query: 836 GQRTICHYIVEAGASLMKTDQQGDTPRQRAEKA 868
G C ++ G+ QG T Q +A
Sbjct: 602 GHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEA 634
Score = 40.0 bits (92), Expect = 0.010
Identities = 35/119 (29%), Positives = 52/119 (43%), Gaps = 5/119 (4%)
Query: 761 LIEAAKRNDFCKLQELHRAGGDLMHRDEQSR--TLLHHAVSTGSKDVVRYLLDHAPPEIL 818
L+EA+K D +++L + ++ RD + R T LH A VV YLL H +
Sbjct: 654 LLEASKAGDLETVKQLC-SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGAD--V 710
Query: 819 DAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYL 877
A ++ G LH A + G + +V GAS+ D TP A E+ L
Sbjct: 711 HAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLL 769
Score = 38.5 bits (88), Expect = 0.028
Identities = 41/159 (25%), Positives = 63/159 (39%), Gaps = 28/159 (17%)
Query: 732 TPTSPLPTSPCSP------TPRSLQGDAAPPQG-----------------EELIEAAKRN 768
+PTS +SP SP +P + + P G EL+EA +
Sbjct: 134 SPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNG 193
Query: 769 DFCKLQELHRAGGDLMHRDEQSR--TLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGE 826
D +++ L A ++ +D R + LH A G KDVV +LL + A ++ G
Sbjct: 194 DVSRVKRLVDAA-NVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGAN--VHARDDGGL 250
Query: 827 TCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRA 865
LH A + G + ++ GA D TP A
Sbjct: 251 IPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEA 289
Score = 35.0 bits (79), Expect = 0.31
Identities = 26/86 (30%), Positives = 43/86 (50%), Gaps = 2/86 (2%)
Query: 764 AAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEE 823
AA N +Q L + G D+ +D+ LH+A S G +V LL H ++A++
Sbjct: 376 AAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHG--ACVNAMDL 433
Query: 824 NGETCLHQAAALGQRTICHYIVEAGA 849
T LH+AA+ + +C ++ GA
Sbjct: 434 WQFTPLHEAASKNRVEVCSLLLSHGA 459
Score = 33.9 bits (76), Expect = 0.69
Identities = 25/78 (32%), Positives = 41/78 (52%), Gaps = 4/78 (5%)
Query: 773 LQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLL-DHAPPEILDAVEENGETCLHQ 831
++ L + G ++ RD+ LH+A S G +VV LL A P +A + T LH+
Sbjct: 232 VEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADP---NARDNWNYTPLHE 288
Query: 832 AAALGQRTICHYIVEAGA 849
AA G+ +C +++ GA
Sbjct: 289 AAIKGKIDVCIVLLQHGA 306
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,257,096
Number of Sequences: 37866
Number of extensions: 2093027
Number of successful extensions: 18451
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 361
Number of HSP's successfully gapped in prelim test: 472
Number of HSP's that attempted gapping in prelim test: 12239
Number of HSP's gapped (non-prelim): 5792
length of query: 895
length of database: 18,247,518
effective HSP length: 111
effective length of query: 784
effective length of database: 14,044,392
effective search space: 11010803328
effective search space used: 11010803328
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.