Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 38569493
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38569493 potassium voltage-gated channel, subfamily H
(eag-related), member 3 [Homo sapiens]
(1083 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re... 2201 0.0
gi|27886667 potassium voltage-gated channel, subfamily H, member... 947 0.0
gi|6912446 potassium voltage-gated channel, subfamily H, member ... 919 0.0
gi|13540549 potassium voltage-gated channel, subfamily H, member... 536 e-152
gi|4504831 potassium voltage-gated channel, subfamily H, member ... 513 e-145
gi|27437001 potassium voltage-gated channel, subfamily H, member... 504 e-142
gi|22024390 potassium voltage-gated channel, subfamily H, member... 502 e-142
gi|27886646 potassium voltage-gated channel, subfamily H, member... 468 e-131
gi|26051273 voltage-gated potassium channel, subfamily H, member... 448 e-125
gi|4557729 voltage-gated potassium channel, subfamily H, member ... 448 e-125
gi|27886648 potassium voltage-gated channel, subfamily H, member... 442 e-124
gi|27886653 potassium voltage-gated channel, subfamily H, member... 422 e-118
gi|26051271 voltage-gated potassium channel, subfamily H, member... 394 e-109
gi|27886665 potassium voltage-gated channel, subfamily H, member... 307 4e-83
gi|27886651 potassium voltage-gated channel, subfamily H, member... 275 2e-73
gi|156071470 hyperpolarization activated cyclic nucleotide-gated... 154 6e-37
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p... 153 7e-37
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [... 152 1e-36
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho... 152 1e-36
gi|116325989 hyperpolarization activated cyclic nucleotide-gated... 145 3e-34
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [... 137 7e-32
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H... 137 7e-32
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ... 134 4e-31
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens] 131 4e-30
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens] 126 1e-28
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H... 90 1e-17
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens] 79 2e-14
gi|163965366 nascent polypeptide-associated complex alpha subuni... 63 1e-09
gi|41281612 zinc finger protein 828 [Homo sapiens] 62 3e-09
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 60 9e-09
>gi|38569493 potassium voltage-gated channel, subfamily H
(eag-related), member 3 [Homo sapiens]
Length = 1083
Score = 2201 bits (5704), Expect = 0.0
Identities = 1083/1083 (100%), Positives = 1083/1083 (100%)
Query: 1 MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV 60
MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV
Sbjct: 1 MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV 60
Query: 61 MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120
MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK
Sbjct: 61 MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120
Query: 121 GEVALFLVSHKDISETKNRGGPDRWKETGGGRRRYGRARSKGFNANRRRSRAVLYHLSGH 180
GEVALFLVSHKDISETKNRGGPDRWKETGGGRRRYGRARSKGFNANRRRSRAVLYHLSGH
Sbjct: 121 GEVALFLVSHKDISETKNRGGPDRWKETGGGRRRYGRARSKGFNANRRRSRAVLYHLSGH 180
Query: 181 LQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAV 240
LQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAV
Sbjct: 181 LQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAV 240
Query: 241 TVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICL 300
TVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICL
Sbjct: 241 TVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICL 300
Query: 301 HYVTTWFLLDVIAALPFDLLHAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVL 360
HYVTTWFLLDVIAALPFDLLHAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVL
Sbjct: 301 HYVTTWFLLDVIAALPFDLLHAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVL 360
Query: 361 TLLMAVFALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGG 420
TLLMAVFALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGG
Sbjct: 361 TLLMAVFALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGG 420
Query: 421 NSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKI 480
NSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKI
Sbjct: 421 NSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKI 480
Query: 481 FSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLE 540
FSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLE
Sbjct: 481 FSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLE 540
Query: 541 YFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLALRP 600
YFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLALRP
Sbjct: 541 YFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLALRP 600
Query: 601 AFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKANA 660
AFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKANA
Sbjct: 601 AFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKANA 660
Query: 661 DVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNLGAGGGSAEVDTSSLSG 720
DVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNLGAGGGSAEVDTSSLSG
Sbjct: 661 DVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNLGAGGGSAEVDTSSLSG 720
Query: 721 DNTLMSTLEEKETDGEQGPTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLG 780
DNTLMSTLEEKETDGEQGPTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLG
Sbjct: 721 DNTLMSTLEEKETDGEQGPTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLG 780
Query: 781 GRGRPGRAGALKAEAGPSAPPRALEGLRLPPMPWNVPPDLSPRVVDGIEDGCGSDQPKFS 840
GRGRPGRAGALKAEAGPSAPPRALEGLRLPPMPWNVPPDLSPRVVDGIEDGCGSDQPKFS
Sbjct: 781 GRGRPGRAGALKAEAGPSAPPRALEGLRLPPMPWNVPPDLSPRVVDGIEDGCGSDQPKFS 840
Query: 841 FRVGQSGPECSSSPSPGPESGLLTVPHGPSEARNTDTLDKLRQAVTELSEQVLQMREGLQ 900
FRVGQSGPECSSSPSPGPESGLLTVPHGPSEARNTDTLDKLRQAVTELSEQVLQMREGLQ
Sbjct: 841 FRVGQSGPECSSSPSPGPESGLLTVPHGPSEARNTDTLDKLRQAVTELSEQVLQMREGLQ 900
Query: 901 SLRQAVQLVLAPHREGPCPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGT 960
SLRQAVQLVLAPHREGPCPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGT
Sbjct: 901 SLRQAVQLVLAPHREGPCPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGT 960
Query: 961 WPHPRPGPPPLMAPWPWGPPASQSSPWPRATAFWTSTSDSEPPASGDLCSEPSTPASPPP 1020
WPHPRPGPPPLMAPWPWGPPASQSSPWPRATAFWTSTSDSEPPASGDLCSEPSTPASPPP
Sbjct: 961 WPHPRPGPPPLMAPWPWGPPASQSSPWPRATAFWTSTSDSEPPASGDLCSEPSTPASPPP 1020
Query: 1021 SEEGARTGPAEPVSQAEATSTGEPPPGSGGLALPWDPHSLEMVLIGCHGSGTVQWTQEEG 1080
SEEGARTGPAEPVSQAEATSTGEPPPGSGGLALPWDPHSLEMVLIGCHGSGTVQWTQEEG
Sbjct: 1021 SEEGARTGPAEPVSQAEATSTGEPPPGSGGLALPWDPHSLEMVLIGCHGSGTVQWTQEEG 1080
Query: 1081 TGV 1083
TGV
Sbjct: 1081 TGV 1083
>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
[Homo sapiens]
Length = 1107
Score = 947 bits (2447), Expect = 0.0
Identities = 524/993 (52%), Positives = 669/993 (67%), Gaps = 66/993 (6%)
Query: 1 MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV 60
MP M+GLLAPQNTFLDTIATRFDGTHSNF+L NAQVA FP+VYCSDGFC+L GF+R EV
Sbjct: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV 60
Query: 61 MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120
MQ+ C+C FL+G +T+E + QI K+L+E EFK E++ Y+K+G PFWCLLD++PIKNEK
Sbjct: 61 MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120
Query: 121 GEVALFLVSHKDISETKNRGGPDRWKETG-GGRRRYGRARSKGFNANRRRSRAVLYHLSG 179
G+V LFL S KDI++TK + P+ KE GR R G F++ RRRSRAVLYH+SG
Sbjct: 121 GDVVLFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTH----FDSARRRSRAVLYHISG 176
Query: 180 HLQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVA 239
HLQ++ K K K+N VF +KP PEYKV+ +KS FILLH +A WD ILLAT YVA
Sbjct: 177 HLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVA 236
Query: 240 VTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSIC 299
VTVPY+VC + S R +V D+AVE+LFI+DI+LNFRTT+VSKSGQV+F +SIC
Sbjct: 237 VTVPYNVCFIGNDDLSTTRST-TVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSIC 295
Query: 300 LHYVTTWFLLDVIAALPFDLLHAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVV 359
+HYVTTWF++D+IAALPFDLL+AF V V HLLKTVRLLRLLRLL +LDRYSQ+S +V
Sbjct: 296 IHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIV 355
Query: 360 LTLLMAVFALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAG 419
LTLLM++FALLAHW+AC+W+ IG+ E E + E+GWL EL +RLE+PYY
Sbjct: 356 LTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYY-------- 407
Query: 420 GNSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEK 479
GN++ LGGPS+RSAYI +LYF LSSLTSVGFGNVSANTD EK
Sbjct: 408 GNNT-------------------LGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEK 448
Query: 480 IFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRML 539
IFSICTMLIGALMHA+VFGNVTAIIQRMY+R LYH+RT+DL+D+IR+H +P+ LKQRML
Sbjct: 449 IFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRML 508
Query: 540 EYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLALR 599
EYFQ TW+VNNGID+ ELL+ PDELR+DI MHL+KE+LQL LFE ASRGCLR+LSL ++
Sbjct: 509 EYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIK 568
Query: 600 PAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKAN 659
+FC PGEYL+ QGDALQA+YFVCSGSMEVLK VLAILGKGDLIG L ++QV+K N
Sbjct: 569 TSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTN 628
Query: 660 ADVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNLGAGGGS--------- 710
ADVK LTYC LQC+ L GL + L LYPE+A +F ++ +L+YNL G S
Sbjct: 629 ADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNK 688
Query: 711 AEVDTSSLSGDNTLMSTL------EEKETDGEQGPTVSPAPADEPSSPLLSPGCTSSSSA 764
+ V S G+ + L EE+E +GE+ VS +P S + S+ +
Sbjct: 689 SMVSQSEPKGNGNINKRLPSIVEDEEEEEEGEEEEAVSLSPICTRGSSSRNKKVGSNKAY 748
Query: 765 AKLLSPRRTAPRPRLGGRGRPGRAGALKAEAG---PSAPPRALEGLRLPPMPWNV--PPD 819
L + + R R+ + K + P+ R + L+L N PPD
Sbjct: 749 LGLSLKQLASGTVPFHSPIRVSRSNSPKTKQEIDPPNHNKRKEKNLKLQLSTLNNAGPPD 808
Query: 820 LSPRVVDGIEDGCGSDQPK-FSFRVGQSGPECSSSPSPG-PESGLLTVPHGPSEARNTDT 877
LSPR+VDGIEDG S++ + F F + E SP G PE G + E +
Sbjct: 809 LSPRIVDGIEDGNSSEESQTFDFGSERIRSEPRISPPLGDPEIGAAVLFIKAEETK--QQ 866
Query: 878 LDKLRQAVTELSEQVLQMREGLQSLRQAVQLVLAPHREGPCPRASGEGPCPASTS----- 932
++KL VT L+++V Q+ + ++++ Q ++ VL+P + CP+ S
Sbjct: 867 INKLNSEVTTLTQEVSQLGKDMRNVIQLLENVLSPQQPSRFCSLHSTSVCPSRESLQTRT 926
Query: 933 --GLLQP-LCVDTGASSYC-LQPPAGSVLSGTW 961
QP L + TG ++Y Q + ++ S W
Sbjct: 927 SWSAHQPCLHLQTGGAAYTQAQLCSSNITSDIW 959
>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
[Homo sapiens]
Length = 1017
Score = 919 bits (2374), Expect = 0.0
Identities = 528/1040 (50%), Positives = 658/1040 (63%), Gaps = 95/1040 (9%)
Query: 1 MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV 60
MP M+GLLAPQNTFLDTIATRFDGTHSNF+L NAQ FP+VYCSDGFC+LTG+ R EV
Sbjct: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV 60
Query: 61 MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120
MQ+ C+C FLYGP+TSE Q++ KAL+ H+E +AE+ YRK G FWCLLD++PIKNE
Sbjct: 61 MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120
Query: 121 GEVALFLVSHKDISETKNRG-GPDRWKETGGGRRRYGRARSKG-FNANRRRSRAVLYHLS 178
GEV LFL S KDI+++ + G GP + GR + F + RRRSR VL+ L+
Sbjct: 121 GEVVLFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLT 180
Query: 179 GHLQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYV 238
GH ++ +G K N VF KP++PEYKVA++ S +LLH +A WDG ILLAT YV
Sbjct: 181 GHFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYV 240
Query: 239 AVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSI 298
AVTVPY+VC S + V D+AVE+LFILDI+LNFRTT+VS+SGQV+ AP+SI
Sbjct: 241 AVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSI 300
Query: 299 CLHYVTTWFLLDVIAALPFDLLHAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAV 358
LHY+ TWF +D+IAALPFDLL+ F + V HLLKTVRLLRLLRLL +L+RYSQ SAV
Sbjct: 301 GLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAV 360
Query: 359 VLTLLMAVFALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPA 418
VLTLLM+VFALLAHW+AC+W+ IG+RE+E+++ L +IGWL EL +RLE PY
Sbjct: 361 VLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPY-------- 412
Query: 419 GGNSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTE 478
NG+ +GGPS RSAYI +LYF LSSLTSVGFGNV ANTD E
Sbjct: 413 ----------------VNGS----VGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAE 452
Query: 479 KIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRM 538
KIFSICTMLIGALMHAVVFGNVTAIIQRMY+RR LYHSR +DL+D+IR+HR+P+PLKQRM
Sbjct: 453 KIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRM 512
Query: 539 LEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLAL 598
LEYFQ TWAVN+GID ELL+ PDELRADIAMHL++E+LQLPLF AASRGCLRALSL +
Sbjct: 513 LEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQLPLFGAASRGCLRALSLHI 572
Query: 599 RPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQ---- 654
+ +FC PGEYL+ +GDALQA Y+VCSGS+EVL+ VLAILGKGDLIG ++P Q
Sbjct: 573 KTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPEPGQEPGL 632
Query: 655 ------VVKANADVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNLGAGG 708
V+K +ADVK LTYC LQ L GL + L LYPE+ F GL +L++NL G
Sbjct: 633 GADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGS 692
Query: 709 GSAEV--------------DTSSLSGDNTLMSTLEEKETDGEQGPTVSPAPADEPSSPLL 754
++ + ++ S D TL S T+ E G P P PLL
Sbjct: 693 DTSGLSRFSRSPRLSQPRSESLGSSSDKTLPSI-----TEAESG--AEPGGGPRPRRPLL 745
Query: 755 SPGCTSSSSAAKLLS------PRRTA--PRPRLGGRGRPGRAGALKAEAGPSAPPRALEG 806
P + + L+S P +A P L P AG A P PPR
Sbjct: 746 LPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPSLSPALAGQ-GHSASPHGPPRCSAA 804
Query: 807 -----LRLPPMPWNVPPDLSPRVVDGIED-GCGSDQPKFSFRVGQSGPECSSSPSPGPES 860
L +PP+ PPDLSPR+VDGIED G ++ P F F PE S P +
Sbjct: 805 WKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAEAPSFRF---SRRPELPRPRSQAPPT 861
Query: 861 GLLTVPHGPSEARNT-DTLDKLRQAVTELSEQVLQMREGLQSLRQAVQLVLAP--HREG- 916
G P SEA + + +L Q ++ L+++V Q+ L+ + +Q L P H G
Sbjct: 862 GTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQLSRELRHIMGLLQARLGPPGHPAGS 921
Query: 917 ------PCPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGTW---PHPRPG 967
PCP+ PC + + P DT + G++ +GT P
Sbjct: 922 AWTPDPPCPQL--RPPCLSPCASRPPPSLQDTTLAEVHCPASVGTMETGTALLDLRPSIL 979
Query: 968 PPPLMAPWPWGP-PASQSSP 986
PP P P GP P ++SP
Sbjct: 980 PPYPSEPDPLGPSPVPEASP 999
>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
isoform 1 [Homo sapiens]
Length = 994
Score = 536 bits (1382), Expect = e-152
Identities = 323/853 (37%), Positives = 464/853 (54%), Gaps = 93/853 (10%)
Query: 1 MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV 60
MP RG +APQNT+LDTI +F+G F++ NAQ+ ++YC+DGFC+L G+SR EV
Sbjct: 1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENC-AIIYCNDGFCELFGYSRVEV 59
Query: 61 MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120
MQ+ C C FL GP+T ++ +AL +E K +++ YRK F CL+DV+P+KNE
Sbjct: 60 MQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNED 119
Query: 121 GEVALFLVSHKDISETKNR-------------------------GGPDRWKETGGGRRRY 155
G V +F+++ +D+++ + GGP G GR +Y
Sbjct: 120 GAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPG----PGTGRGKY 175
Query: 156 GRARSK---------GFNANRRRSRAV--LYHLSGH--LQKQPKGKHKLNKGVFGEKPNL 202
R S+ FN + RS + + ++ H +++ K+ + + L
Sbjct: 176 -RTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVL 234
Query: 203 PEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARG--- 259
PEYK+ A R + +LH +A WD ILL +Y AV PYS + + + RG
Sbjct: 235 PEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACS 294
Query: 260 ----PPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAAL 315
P +V DL V+++F++DIV+NFRTT+V+ + +VV P+ I +HY WFL+D++AA+
Sbjct: 295 YTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAI 354
Query: 316 PFDLL----HAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLA 371
PFDLL + + G LLKT RLLRL+R+ +LDRYS+Y A VL LLM FAL+A
Sbjct: 355 PFDLLIFRTGSDETTTLIG--LLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 412
Query: 372 HWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSS 431
HW+AC+W+ IG E E +IGWL L +L Y
Sbjct: 413 HWLACIWYAIGNVERPYLEH---KIGWLDSLGVQLGKRY--------------------- 448
Query: 432 SSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGAL 491
G + GPS++ Y+T+LYF SSLTSVGFGNVS NT++EK+FSIC MLIG+L
Sbjct: 449 ------NGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSL 502
Query: 492 MHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNG 551
M+A +FGNV+AIIQR+Y+ YH++ ++++IR H+IP PL+QR+ EYFQ W+ NG
Sbjct: 503 MYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNG 562
Query: 552 IDTTELLQSLPDELRADIAMHLHKEVLQ-LPLFEAASRGCLRALSLALRPAFCTPGEYLI 610
ID +L+ P+ L+ADI +HLH+ +LQ P F A +GCLRAL++ + PG+ L+
Sbjct: 563 IDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLV 622
Query: 611 HQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKANADVKGLTYCVL 670
H GD L LYF+ GS+E+L+ V+AILGK D+ G + Q K++ADV+ LTYC L
Sbjct: 623 HLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDL 682
Query: 671 QCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNLGAGGGSAEVDTSSLSGDNTLMSTLEE 730
+Q A L + L +YP FA F L E+++NL G G
Sbjct: 683 HKIQRADLLEVLDMYPAFAESFWSKL--EVTFNLRDAAGGLHSSPRQAPGSQDHQGFFLS 740
Query: 731 KETDGEQGPTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPGRAGA 790
G P+ S LL PG +S A +P P L G
Sbjct: 741 DNQSGSPHELGPQFPSKGYS--LLGPGSQNSMGAGP-CAPGHPDAAPPLSISDASGLWPE 797
Query: 791 LKAEAGPSAPPRA 803
L E P P++
Sbjct: 798 LLQEMPPRHSPQS 810
>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
isoform 2 [Homo sapiens]
Length = 962
Score = 513 bits (1321), Expect = e-145
Identities = 290/709 (40%), Positives = 436/709 (61%), Gaps = 51/709 (7%)
Query: 5 RGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRG 64
RGL+APQNTFL+ I R + T NFVLGNAQ+ +P+VY +DGFC L+G+ RAEVMQ+
Sbjct: 8 RGLVAPQNTFLENIVRRSNDT--NFVLGNAQIVD-WPIVYSNDGFCKLSGYHRAEVMQKS 64
Query: 65 CACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVA 124
CSF+YG T + +++R+ + ++ E+++Y+K+ P W + + PI+NE+ +V
Sbjct: 65 STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
Query: 125 LFLVSHKDISETKNRGGPDRWKETGGGR-RRYGRARSKGFNANRRRSRAVLYHLSGHLQK 183
LFL + DI+ K D K G G+ R RA + SR VL L+ +QK
Sbjct: 125 LFLCTFSDITAFKQPIEDDSCK--GWGKFARLTRALTS--------SRGVLQQLAPSVQK 174
Query: 184 -QPKGKH-KLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVT 241
+ KH +L + + LP+YK A + P I+LH + TWD IL+ T Y A+
Sbjct: 175 GENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAIL 234
Query: 242 VPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLH 301
VPY+V T + A V D V+V+F++DIVLNF TTFV +G+V+ PK I ++
Sbjct: 235 VPYNVSFKTRQNNVAWL----VVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMN 290
Query: 302 YVTTWFLLDVIAALPFDLLHAFKVNVYFGAHLL----KTVRLLRLLRLLPRLDRYSQYSA 357
Y+ TWF++D+++ LP+D+++AF+ NV G L K VRLLRL R+ +LD Y +Y A
Sbjct: 291 YLKTWFVIDLLSCLPYDVINAFE-NVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGA 349
Query: 358 VVLTLLMAVFALLAHWVACVWFYIGQREIESSESE-LPEIGWLQELARRLETPYYLVGRR 416
VL LL+ VF L AHW+AC+W+ IG EI +++ + WL +LA + TPY
Sbjct: 350 AVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQF---- 405
Query: 417 PAGGNSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTD 476
G+ SG+ + GGPS S YI+SLYF ++SLTSVGFGN++ +TD
Sbjct: 406 --NGSGSGKWE----------------GGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTD 447
Query: 477 TEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQ 536
EKIF++ M+IG+L++A +FGNVT I Q+MYA YH +RD+++++++PK L +
Sbjct: 448 IEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSE 507
Query: 537 RMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALS 595
R+++Y +TW+++ GIDT ++LQ P ++RADI +HL+++V + P F AS GCLRAL+
Sbjct: 508 RVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALA 567
Query: 596 LALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQV 655
+ + C PG+ + H G+++ +L FV SGS+EV++ V+AILGKGD+ G + +
Sbjct: 568 MEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATL 627
Query: 656 VKANADVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNL 704
++ A+V+ LTYC L ++ L L Y F+ FSR L L+YNL
Sbjct: 628 AQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNL--ILTYNL 674
>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
isoform 1 [Homo sapiens]
Length = 989
Score = 504 bits (1299), Expect = e-142
Identities = 289/735 (39%), Positives = 437/735 (59%), Gaps = 76/735 (10%)
Query: 5 RGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRG 64
RGL+APQNTFL+ I R + T NFVLGNAQ+ +P+VY +DGFC L+G+ RAEVMQ+
Sbjct: 8 RGLVAPQNTFLENIVRRSNDT--NFVLGNAQIVD-WPIVYSNDGFCKLSGYHRAEVMQKS 64
Query: 65 CACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVA 124
CSF+YG T + +++R+ + ++ E+++Y+K+ P W + + PI+NE+ +V
Sbjct: 65 STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
Query: 125 LFLVSHKDISETKNRGGPDRWKETGGGR-RRYGRARSKGFNANRRRSRAVLYHLSGHLQK 183
LFL + DI+ K D K G G+ R RA + SR VL L+ +QK
Sbjct: 125 LFLCTFSDITAFKQPIEDDSCK--GWGKFARLTRALTS--------SRGVLQQLAPSVQK 174
Query: 184 -QPKGKH-KLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVT 241
+ KH +L + + LP+YK A + P I+LH + TWD IL+ T Y A+
Sbjct: 175 GENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAIL 234
Query: 242 VPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLH 301
VPY+V T + A V D V+V+F++DIVLNF TTFV +G+V+ PK I ++
Sbjct: 235 VPYNVSFKTRQNNVAW----LVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMN 290
Query: 302 YVTTWFLLDVIAALPFDLLHAF----KVNVYFG--------------------------A 331
Y+ TWF++D+++ LP+D+++AF +V+ + G
Sbjct: 291 YLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLF 350
Query: 332 HLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQREIESSES 391
LK VRLLRL R+ +LD Y +Y A VL LL+ VF L AHW+AC+W+ IG EI ++
Sbjct: 351 SSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDT 410
Query: 392 E-LPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGLELLGGPSLRS 450
+ + WL +LA + TPY G+ SG+ + GGPS S
Sbjct: 411 KTIRNNSWLYQLAMDIGTPYQF------NGSGSGKWE----------------GGPSKNS 448
Query: 451 AYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYAR 510
YI+SLYF ++SLTSVGFGN++ +TD EKIF++ M+IG+L++A +FGNVT I Q+MYA
Sbjct: 449 VYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYAN 508
Query: 511 RFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIA 570
YH +RD+++++++PK L +R+++Y +TW+++ GIDT ++LQ P ++RADI
Sbjct: 509 TNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADIC 568
Query: 571 MHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEV 629
+HL+++V + P F AS GCLRAL++ + C PG+ + H G+++ +L FV SGS+EV
Sbjct: 569 VHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEV 628
Query: 630 LKGGTVLAILGKGDLIGCELPRREQVVKANADVKGLTYCVLQCLQLAGLHDSLALYPEFA 689
++ V+AILGKGD+ G + + ++ A+V+ LTYC L ++ L L Y F+
Sbjct: 629 IQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFS 688
Query: 690 PRFSRGLRGELSYNL 704
FSR L L+YNL
Sbjct: 689 HSFSRNL--ILTYNL 701
>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
isoform 1 [Homo sapiens]
Length = 988
Score = 502 bits (1292), Expect = e-142
Identities = 281/699 (40%), Positives = 424/699 (60%), Gaps = 47/699 (6%)
Query: 5 RGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRG 64
RGL+APQNTFL+ I R + S+F+LGNAQ+ +PVVY +DGFC L+G+ RA+VMQ+
Sbjct: 6 RGLVAPQNTFLENIVRR--SSESSFLLGNAQIVD-WPVVYSNDGFCKLSGYHRADVMQKS 62
Query: 65 CACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVA 124
CSF+YG T + +++R+ D ++ E++LY+K+ P W + + PI+NE +V
Sbjct: 63 STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122
Query: 125 LFLVSHKDISETKNRGGPDRWKETGGGRRRYGRARSKGFNANRRRSRAVLYHLSGHLQKQ 184
LFL + KDI+ K D K G ++ R N SR+VL L+ + +
Sbjct: 123 LFLCTFKDITLFKQPIEDDSTK----GWTKFARLTRALTN-----SRSVLQQLTPMNKTE 173
Query: 185 PKGKH-KLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVP 243
KH +L + + LP+YK A + P I+LH A + TWD IL+ T Y A+ VP
Sbjct: 174 VVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVP 233
Query: 244 YSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYV 303
Y+V T + A V D V+V+F++DIVLNF TTFV G+V+ PK I ++Y+
Sbjct: 234 YNVSFKTKQNNIAW----LVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYL 289
Query: 304 TTWFLLDVIAALPFDLLHAFKVNVYFGA----HLLKTVRLLRLLRLLPRLDRYSQYSAVV 359
TWF++D+++ LP+D+++AF+ NV G LK VRLLRL R+ +LD Y +Y A V
Sbjct: 290 KTWFVIDLLSCLPYDIINAFE-NVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAV 348
Query: 360 LTLLMAVFALLAHWVACVWFYIGQREIESSESELPEI-GWLQELARRLETPYYLVGRRPA 418
L LL+ VF L+AHW+AC+W+ IG E+ + +I WL +LA + TPY
Sbjct: 349 LVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRY------ 402
Query: 419 GGNSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTE 478
S+G + GGPS S Y++SLYF ++SLT++GFGN++ TD E
Sbjct: 403 -NTSAGIWE----------------GGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVE 445
Query: 479 KIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRM 538
K+FS+ M++G+L++A +FGNVT I Q+MYA YH ++RD+++++++PK L +R+
Sbjct: 446 KMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERV 505
Query: 539 LEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLA 597
++Y +TW+++ GIDT ++L P ++RADI +HL+++V + P F AS GCLRAL++
Sbjct: 506 MDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVE 565
Query: 598 LRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVK 657
+ C PG+ + H G+++ AL FV SGS+EV++ V+AILGKGD+ G + +
Sbjct: 566 FQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAH 625
Query: 658 ANADVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGL 696
A A+V+ LTYC L ++ L L Y FA FSR L
Sbjct: 626 ACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNL 664
>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
isoform 3 [Homo sapiens]
Length = 611
Score = 468 bits (1204), Expect = e-131
Identities = 259/642 (40%), Positives = 395/642 (61%), Gaps = 47/642 (7%)
Query: 5 RGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRG 64
RGL+APQNTFL+ I R + S+F+LGNAQ+ +PVVY +DGFC L+G+ RA+VMQ+
Sbjct: 6 RGLVAPQNTFLENIVRR--SSESSFLLGNAQIVD-WPVVYSNDGFCKLSGYHRADVMQKS 62
Query: 65 CACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVA 124
CSF+YG T + +++R+ D ++ E++LY+K+ P W + + PI+NE +V
Sbjct: 63 STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122
Query: 125 LFLVSHKDISETKNRGGPDRWKETGGGRRRYGRARSKGFNANRRRSRAVLYHLSGHLQKQ 184
LFL + KDI+ K D K G ++ R N SR+VL L+ + +
Sbjct: 123 LFLCTFKDITLFKQPIEDDSTK----GWTKFARLTRALTN-----SRSVLQQLTPMNKTE 173
Query: 185 PKGKH-KLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVP 243
KH +L + + LP+YK A + P I+LH A + TWD IL+ T Y A+ VP
Sbjct: 174 VVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVP 233
Query: 244 YSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYV 303
Y+V T + A V D V+V+F++DIVLNF TTFV G+V+ PK I ++Y+
Sbjct: 234 YNVSFKTKQNNIAW----LVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYL 289
Query: 304 TTWFLLDVIAALPFDLLHAFKVNVYFGA----HLLKTVRLLRLLRLLPRLDRYSQYSAVV 359
TWF++D+++ LP+D+++AF+ NV G LK VRLLRL R+ +LD Y +Y A V
Sbjct: 290 KTWFVIDLLSCLPYDIINAFE-NVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAV 348
Query: 360 LTLLMAVFALLAHWVACVWFYIGQREIESSESELPEI-GWLQELARRLETPYYLVGRRPA 418
L LL+ VF L+AHW+AC+W+ IG E+ + +I WL +LA + TPY
Sbjct: 349 LVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRY------ 402
Query: 419 GGNSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTE 478
S+G + GGPS S Y++SLYF ++SLT++GFGN++ TD E
Sbjct: 403 -NTSAGIWE----------------GGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVE 445
Query: 479 KIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRM 538
K+FS+ M++G+L++A +FGNVT I Q+MYA YH ++RD+++++++PK L +R+
Sbjct: 446 KMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERV 505
Query: 539 LEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLA 597
++Y +TW+++ GIDT ++L P ++RADI +HL+++V + P F AS GCLRAL++
Sbjct: 506 MDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVE 565
Query: 598 LRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAIL 639
+ C PG+ + H G+++ AL FV SGS+EV++ V+AIL
Sbjct: 566 FQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAIL 607
>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
isoform c [Homo sapiens]
Length = 819
Score = 448 bits (1153), Expect = e-125
Identities = 300/782 (38%), Positives = 408/782 (52%), Gaps = 119/782 (15%)
Query: 202 LPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCV--------STARE 253
LPEYK+ A R + +LH +A WD ILL +Y AV PYS A E
Sbjct: 45 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 104
Query: 254 PSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIA 313
A P +V DL V+++FI+DI++NFRTT+V+ + +VV P I +HY WFL+D++A
Sbjct: 105 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 164
Query: 314 ALPFDLLHAFKVNVYFGAH------LLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVF 367
A+PFDLL FG+ LLKT RLLRL+R+ +LDRYS+Y A VL LLM F
Sbjct: 165 AIPFDLL-------IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTF 217
Query: 368 ALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSD 427
AL+AHW+AC+W+ IG E +S IGWL L ++ PY NSSG
Sbjct: 218 ALIAHWLACIWYAIGNMEQPHMDSR---IGWLHNLGDQIGKPY----------NSSG--- 261
Query: 428 NCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTML 487
LGGPS++ Y+T+LYF SSLTSVGFGNVS NT++EKIFSIC ML
Sbjct: 262 ---------------LGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 306
Query: 488 IGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWA 547
IG+LM+A +FGNV+AIIQR+Y+ YH++ +R++IR H+IP PL+QR+ EYFQ W+
Sbjct: 307 IGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWS 366
Query: 548 VNNGIDTTELLQSLPDELRADIAMHLHKEVLQ-LPLFEAASRGCLRALSLALRPAFCTPG 606
NGID +L+ P+ L+ADI +HL++ +LQ F A++GCLRAL++ + PG
Sbjct: 367 YTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPG 426
Query: 607 EYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKANADVKGLT 666
+ L+H GD L ALYF+ GS+E+L+G V+AILGK D+ G L + K+N DV+ LT
Sbjct: 427 DTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALT 486
Query: 667 YCVLQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNL------GAGGGSAEVDTSSLSG 720
YC L + L + L +YPEF+ F L E+++NL GS E++
Sbjct: 487 YCDLHKIHRDDLLEVLDMYPEFSDHFWSSL--EITFNLRDTNMIPGSPGSTELEGGFSRQ 544
Query: 721 DNTLMSTLEEKETDGEQGPTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLG 780
+S + D EQ PG S+ L P R P
Sbjct: 545 RKRKLSFRRRTDKDTEQ------------------PGEVSA------LGPGRAGAGP--S 578
Query: 781 GRGRPGRAGALKAEAGPSAPP--------RALEGLRLPPMPWNVPPDLSP---RVVDGIE 829
RGRPG +GPS+P R+ LRL P PP P +++ E
Sbjct: 579 SRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCE 638
Query: 830 DGCGSDQPK----------FSFRVGQSGPECSSSP-SPGPESGLLTVP-HGPSEARNTDT 877
+ P FSF G + P P P LL +P P D
Sbjct: 639 KSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDV 698
Query: 878 ---LDKLRQAVTELSEQV-LQMREGLQSLRQAVQLVLAPHREGPCPRASGEGPCPASTSG 933
LD L++ + L ++ M LQ L++ + LV + P GP P STS
Sbjct: 699 ESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTP-----GPGPTSTSP 753
Query: 934 LL 935
LL
Sbjct: 754 LL 755
>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
isoform a [Homo sapiens]
Length = 1159
Score = 448 bits (1153), Expect = e-125
Identities = 300/782 (38%), Positives = 408/782 (52%), Gaps = 119/782 (15%)
Query: 202 LPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCV--------STARE 253
LPEYK+ A R + +LH +A WD ILL +Y AV PYS A E
Sbjct: 385 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 444
Query: 254 PSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIA 313
A P +V DL V+++FI+DI++NFRTT+V+ + +VV P I +HY WFL+D++A
Sbjct: 445 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 504
Query: 314 ALPFDLLHAFKVNVYFGAH------LLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVF 367
A+PFDLL FG+ LLKT RLLRL+R+ +LDRYS+Y A VL LLM F
Sbjct: 505 AIPFDLL-------IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTF 557
Query: 368 ALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSD 427
AL+AHW+AC+W+ IG E +S IGWL L ++ PY NSSG
Sbjct: 558 ALIAHWLACIWYAIGNMEQPHMDSR---IGWLHNLGDQIGKPY----------NSSG--- 601
Query: 428 NCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTML 487
LGGPS++ Y+T+LYF SSLTSVGFGNVS NT++EKIFSIC ML
Sbjct: 602 ---------------LGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 646
Query: 488 IGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWA 547
IG+LM+A +FGNV+AIIQR+Y+ YH++ +R++IR H+IP PL+QR+ EYFQ W+
Sbjct: 647 IGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWS 706
Query: 548 VNNGIDTTELLQSLPDELRADIAMHLHKEVLQ-LPLFEAASRGCLRALSLALRPAFCTPG 606
NGID +L+ P+ L+ADI +HL++ +LQ F A++GCLRAL++ + PG
Sbjct: 707 YTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPG 766
Query: 607 EYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKANADVKGLT 666
+ L+H GD L ALYF+ GS+E+L+G V+AILGK D+ G L + K+N DV+ LT
Sbjct: 767 DTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALT 826
Query: 667 YCVLQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNL------GAGGGSAEVDTSSLSG 720
YC L + L + L +YPEF+ F L E+++NL GS E++
Sbjct: 827 YCDLHKIHRDDLLEVLDMYPEFSDHFWSSL--EITFNLRDTNMIPGSPGSTELEGGFSRQ 884
Query: 721 DNTLMSTLEEKETDGEQGPTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLG 780
+S + D EQ PG S+ L P R P
Sbjct: 885 RKRKLSFRRRTDKDTEQ------------------PGEVSA------LGPGRAGAGP--S 918
Query: 781 GRGRPGRAGALKAEAGPSAPP--------RALEGLRLPPMPWNVPPDLSP---RVVDGIE 829
RGRPG +GPS+P R+ LRL P PP P +++ E
Sbjct: 919 SRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCE 978
Query: 830 DGCGSDQPK----------FSFRVGQSGPECSSSP-SPGPESGLLTVP-HGPSEARNTDT 877
+ P FSF G + P P P LL +P P D
Sbjct: 979 KSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDV 1038
Query: 878 ---LDKLRQAVTELSEQV-LQMREGLQSLRQAVQLVLAPHREGPCPRASGEGPCPASTSG 933
LD L++ + L ++ M LQ L++ + LV + P GP P STS
Sbjct: 1039 ESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTP-----GPGPTSTSP 1093
Query: 934 LL 935
LL
Sbjct: 1094 LL 1095
Score = 146 bits (369), Expect = 9e-35
Identities = 74/159 (46%), Positives = 98/159 (61%), Gaps = 11/159 (6%)
Query: 1 MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV 60
MP RG +APQNTFLDTI +F+G F++ NA+V V+YC+DGFC+L G+SRAEV
Sbjct: 1 MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENC-AVIYCNDGFCELCGYSRAEV 59
Query: 61 MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120
MQR C C FL+GP T QI +AL +E K E+ YRK G F CL+DV+P+KNE
Sbjct: 60 MQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNED 119
Query: 121 GEVALFLVSHKDISE----------TKNRGGPDRWKETG 149
G V +F+++ + + E T +RG P W G
Sbjct: 120 GAVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPG 158
>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
isoform 2 [Homo sapiens]
Length = 624
Score = 442 bits (1137), Expect = e-124
Identities = 249/643 (38%), Positives = 381/643 (59%), Gaps = 44/643 (6%)
Query: 61 MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120
MQ+ CSF+YG T + +++R+ D ++ E++LY+K+ P W + + PI+NE
Sbjct: 1 MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60
Query: 121 GEVALFLVSHKDISETKNRGGPDRWKETGGGRRRYGRARSKGFNANRRRSRAVLYHLSGH 180
+V LFL + KDI+ K D K G ++ R N SR+VL L+
Sbjct: 61 EKVVLFLCTFKDITLFKQPIEDDSTK----GWTKFARLTRALTN-----SRSVLQQLTPM 111
Query: 181 LQKQPKGKH-KLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVA 239
+ + KH +L + + LP+YK A + P I+LH A + TWD IL+ T Y A
Sbjct: 112 NKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTA 171
Query: 240 VTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSIC 299
+ VPY+V T + A V D V+V+F++DIVLNF TTFV G+V+ PK I
Sbjct: 172 IMVPYNVSFKTKQNNIAWL----VLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIR 227
Query: 300 LHYVTTWFLLDVIAALPFDLLHAFKVNVYFGA----HLLKTVRLLRLLRLLPRLDRYSQY 355
++Y+ TWF++D+++ LP+D+++AF+ NV G LK VRLLRL R+ +LD Y +Y
Sbjct: 228 MNYLKTWFVIDLLSCLPYDIINAFE-NVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEY 286
Query: 356 SAVVLTLLMAVFALLAHWVACVWFYIGQREIESSESELPEI-GWLQELARRLETPYYLVG 414
A VL LL+ VF L+AHW+AC+W+ IG E+ + +I WL +LA + TPY
Sbjct: 287 GAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRY-- 344
Query: 415 RRPAGGNSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSAN 474
S+G + GGPS S Y++SLYF ++SLT++GFGN++
Sbjct: 345 -----NTSAGIWE----------------GGPSKDSLYVSSLYFTMTSLTTIGFGNIAPT 383
Query: 475 TDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPL 534
TD EK+FS+ M++G+L++A +FGNVT I Q+MYA YH ++RD+++++++PK L
Sbjct: 384 TDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGL 443
Query: 535 KQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRA 593
+R+++Y +TW+++ GIDT ++L P ++RADI +HL+++V + P F AS GCLRA
Sbjct: 444 SERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRA 503
Query: 594 LSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRRE 653
L++ + C PG+ + H G+++ AL FV SGS+EV++ V+AILGKGD+ G +
Sbjct: 504 LAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKET 563
Query: 654 QVVKANADVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGL 696
+ A A+V+ LTYC L ++ L L Y FA FSR L
Sbjct: 564 TLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNL 606
>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
isoform 1 [Homo sapiens]
Length = 1196
Score = 422 bits (1086), Expect = e-118
Identities = 234/533 (43%), Positives = 327/533 (61%), Gaps = 46/533 (8%)
Query: 202 LPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCV-------STAREP 254
LPEYK+ R + F +LH +A WD ILL +Y A+ PYS RE
Sbjct: 385 LPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRREC 444
Query: 255 SAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAA 314
+ P +V DL V+++FI+DI++NFRTT+V+++ +VV P I +HY WFL+D++AA
Sbjct: 445 GYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAA 504
Query: 315 LPFDLL----HAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALL 370
+PFDLL + + G LLKT RLLRL+R+ +LDRYS+Y A VL LLM +FAL+
Sbjct: 505 IPFDLLIFGSGSDETTTLIG--LLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALI 562
Query: 371 AHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCS 430
AHW+AC+W+ IG E + IGWL L +++ Y +D+ S
Sbjct: 563 AHWLACIWYAIGNVERPYLTDK---IGWLDSLGQQIGKRY---------------NDSDS 604
Query: 431 SSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGA 490
SS GPS++ Y+T+LYF SSLTSVGFGNVS NT++EKIFSIC MLIG+
Sbjct: 605 SS------------GPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGS 652
Query: 491 LMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNN 550
LM+A +FGNV+AIIQR+Y+ YH + ++++IR H+IP PL+QR+ EYFQ W N
Sbjct: 653 LMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTN 712
Query: 551 GIDTTELLQSLPDELRADIAMHLHKEVLQ-LPLFEAASRGCLRALSLALRPAFCTPGEYL 609
GID +L+ P+ L+ADI +HL++ +LQ F AS+GCLRAL++ + PG+ L
Sbjct: 713 GIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTL 772
Query: 610 IHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKANADVKGLTYCV 669
+H GD L ALYF+ GS+E+LK V+AILGK D+ G + + K+NADV+ LTYC
Sbjct: 773 VHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCD 832
Query: 670 LQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNLGAGGGSAEVDTSSLSGDN 722
L +Q L + L +YPEF+ F L EL++NL A++ S D+
Sbjct: 833 LHKIQREDLLEVLDMYPEFSDHFLTNL--ELTFNLRHESAKADLLRSQSMNDS 883
Score = 135 bits (339), Expect = 3e-31
Identities = 61/144 (42%), Positives = 95/144 (65%), Gaps = 1/144 (0%)
Query: 1 MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV 60
MP RG +APQNTFL TI +F+G + F++ NA+V ++YC+DGFC++TGFSR +V
Sbjct: 1 MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNC-AIIYCNDGFCEMTGFSRPDV 59
Query: 61 MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120
MQ+ C C FL+GP+T QI +AL +E K E+ Y K+G F C +IP+KN++
Sbjct: 60 MQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQE 119
Query: 121 GEVALFLVSHKDISETKNRGGPDR 144
G +F+++ + +++ +N P+R
Sbjct: 120 GVAMMFIINFEYVTDNENAATPER 143
>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
isoform b [Homo sapiens]
Length = 888
Score = 394 bits (1013), Expect = e-109
Identities = 220/490 (44%), Positives = 299/490 (61%), Gaps = 55/490 (11%)
Query: 202 LPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCV--------STARE 253
LPEYK+ A R + +LH +A WD ILL +Y AV PYS A E
Sbjct: 385 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 444
Query: 254 PSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIA 313
A P +V DL V+++FI+DI++NFRTT+V+ + +VV P I +HY WFL+D++A
Sbjct: 445 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 504
Query: 314 ALPFDLLHAFKVNVYFGAH------LLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVF 367
A+PFDLL FG+ LLKT RLLRL+R+ +LDRYS+Y A VL LLM F
Sbjct: 505 AIPFDLL-------IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTF 557
Query: 368 ALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSD 427
AL+AHW+AC+W+ IG E +S IGWL L ++ PY NSSG
Sbjct: 558 ALIAHWLACIWYAIGNMEQPHMDSR---IGWLHNLGDQIGKPY----------NSSG--- 601
Query: 428 NCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTML 487
LGGPS++ Y+T+LYF SSLTSVGFGNVS NT++EKIFSIC ML
Sbjct: 602 ---------------LGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 646
Query: 488 IGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWA 547
IG+LM+A +FGNV+AIIQR+Y+ YH++ +R++IR H+IP PL+QR+ EYFQ W+
Sbjct: 647 IGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWS 706
Query: 548 VNNGIDTTELLQSLPDELRADIAMHLHKEVLQ-LPLFEAASRGCLRALSLALRPAFCTPG 606
NGID +L+ P+ L+ADI +HL++ +LQ F A++GCLRAL++ + PG
Sbjct: 707 YTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPG 766
Query: 607 EYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGK--GDLIGCELPRREQVVKANADVKG 664
+ L+H GD L ALYF+ GS+E+L+G V+AILG G G E+P + +++
Sbjct: 767 DTLVHAGDLLTALYFISRGSIEILRGDVVVAILGMGWGAGTGLEMPSAASRGASLLNMQS 826
Query: 665 LTYCVLQCLQ 674
L CLQ
Sbjct: 827 LGLWTWDCLQ 836
Score = 146 bits (369), Expect = 9e-35
Identities = 74/159 (46%), Positives = 98/159 (61%), Gaps = 11/159 (6%)
Query: 1 MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV 60
MP RG +APQNTFLDTI +F+G F++ NA+V V+YC+DGFC+L G+SRAEV
Sbjct: 1 MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENC-AVIYCNDGFCELCGYSRAEV 59
Query: 61 MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120
MQR C C FL+GP T QI +AL +E K E+ YRK G F CL+DV+P+KNE
Sbjct: 60 MQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNED 119
Query: 121 GEVALFLVSHKDISE----------TKNRGGPDRWKETG 149
G V +F+++ + + E T +RG P W G
Sbjct: 120 GAVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPG 158
>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
isoform 2 [Homo sapiens]
Length = 732
Score = 307 bits (786), Expect = 4e-83
Identities = 166/371 (44%), Positives = 229/371 (61%), Gaps = 43/371 (11%)
Query: 202 LPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCV-------STAREP 254
LPEYK+ R + F +LH +A WD ILL +Y A+ PYS RE
Sbjct: 378 LPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRREC 437
Query: 255 SAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAA 314
+ P +V DL V+++FI+DI++NFRTT+V+++ +VV P I +HY WFL+D++AA
Sbjct: 438 GYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAA 497
Query: 315 LPFDLL----HAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALL 370
+PFDLL + + G LLKT RLLRL+R+ +LDRYS+Y A VL LLM +FAL+
Sbjct: 498 IPFDLLIFGSGSDETTTLIG--LLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALI 555
Query: 371 AHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCS 430
AHW+AC+W+ IG E + IGWL L +++ Y +D+ S
Sbjct: 556 AHWLACIWYAIGNVERPYLTDK---IGWLDSLGQQIGKRY---------------NDSDS 597
Query: 431 SSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGA 490
SS GPS++ Y+T+LYF SSLTSVGFGNVS NT++EKIFSIC MLIG+
Sbjct: 598 SS------------GPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGS 645
Query: 491 LMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNN 550
LM+A +FGNV+AIIQR+Y+ YH + ++++IR H+IP PL+QR+ EYFQ W N
Sbjct: 646 LMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTN 705
Query: 551 GIDTTELLQSL 561
GID + S+
Sbjct: 706 GIDMNMVCMSV 716
Score = 135 bits (339), Expect = 3e-31
Identities = 61/144 (42%), Positives = 95/144 (65%), Gaps = 1/144 (0%)
Query: 1 MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV 60
MP RG +APQNTFL TI +F+G + F++ NA+V ++YC+DGFC++TGFSR +V
Sbjct: 1 MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNC-AIIYCNDGFCEMTGFSRPDV 59
Query: 61 MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120
MQ+ C C FL+GP+T QI +AL +E K E+ Y K+G F C +IP+KN++
Sbjct: 60 MQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQE 119
Query: 121 GEVALFLVSHKDISETKNRGGPDR 144
G +F+++ + +++ +N P+R
Sbjct: 120 GVAMMFIINFEYVTDNENAATPER 143
>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
isoform 2 [Homo sapiens]
Length = 905
Score = 275 bits (702), Expect = 2e-73
Identities = 161/426 (37%), Positives = 241/426 (56%), Gaps = 57/426 (13%)
Query: 1 MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV 60
MP RG +APQNT+LDTI +F+G F++ NAQ+ ++YC+DGFC+L G+SR EV
Sbjct: 1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENC-AIIYCNDGFCELFGYSRVEV 59
Query: 61 MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120
MQ+ C C FL GP+T ++ +AL +E K +++ YRK F CL+DV+P+KNE
Sbjct: 60 MQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNED 119
Query: 121 GEVALFLVSHKDISETKNR-------------------------GGPDRWKETGGGRRRY 155
G V +F+++ +D+++ + GGP G GR +Y
Sbjct: 120 GAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPG----PGTGRGKY 175
Query: 156 GRARSK---------GFNANRRRSRAV--LYHLSGH--LQKQPKGKHKLNKGVFGEKPNL 202
R S+ FN + RS + + ++ H +++ K+ + + L
Sbjct: 176 -RTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVL 234
Query: 203 PEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARG--- 259
PEYK+ A R + +LH +A WD ILL +Y AV PYS + + + RG
Sbjct: 235 PEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACS 294
Query: 260 ----PPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAAL 315
P +V DL V+++F++DIV+NFRTT+V+ + +VV P+ I +HY WFL+D++AA+
Sbjct: 295 YTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAI 354
Query: 316 PFDLL----HAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLA 371
PFDLL + + G LLKT RLLRL+R+ +LDRYS+Y A VL LLM FAL+A
Sbjct: 355 PFDLLIFRTGSDETTTLIG--LLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 412
Query: 372 HWVACV 377
HW+AC+
Sbjct: 413 HWLACI 418
Score = 247 bits (630), Expect = 5e-65
Identities = 136/322 (42%), Positives = 192/322 (59%), Gaps = 16/322 (4%)
Query: 451 AYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYAR 510
A I + SLTSVGFGNVS NT++EK+FSIC MLIG+LM+A +FGNV+AIIQR+Y+
Sbjct: 409 ALIAHWLACICSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSG 468
Query: 511 RFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIA 570
YH++ ++++IR H+IP PL+QR+ EYFQ W+ NGID +L+ P+ L+ADI
Sbjct: 469 TARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADIC 528
Query: 571 MHLHKEVLQ-LPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEV 629
+HLH+ +LQ P F A +GCLRAL++ + PG+ L+H GD L LYF+ GS+E+
Sbjct: 529 LHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEI 588
Query: 630 LKGGTVLAILGKGDLIGCELPRREQVVKANADVKGLTYCVLQCLQLAGLHDSLALYPEFA 689
L+ V+AILGK D+ G + Q K++ADV+ LTYC L +Q A L + L +YP FA
Sbjct: 589 LRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFA 648
Query: 690 PRFSRGLRGELSYNL-GAGGGSAEVDTSSLSGDNTLMSTLEEKETDGEQGPTVSPA---- 744
F L E+++NL A GG + + L + ++D ++S A
Sbjct: 649 ESFWSKL--EVTFNLRDAAGGLHSSPRQAPGSQDHQGFFLSDNQSDAAPPLSISDASGLW 706
Query: 745 --------PADEPSSPLLSPGC 758
P P SP P C
Sbjct: 707 PELLQEMPPRHSPQSPQEDPDC 728
>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
potassium channel 2 [Homo sapiens]
Length = 889
Score = 154 bits (388), Expect = 6e-37
Identities = 178/750 (23%), Positives = 300/750 (40%), Gaps = 115/750 (15%)
Query: 187 GKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSV 246
G +K + +FG + + + +I+ R WD +LL + + +P V
Sbjct: 174 GVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIP--V 231
Query: 247 CVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSG-QVVFAPKSICLHYVTT 305
++ ++ + A P V ++ + F++D+VLNFRT V + +++ P+ I Y+ T
Sbjct: 232 GITFFKDETTA--PWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRT 289
Query: 306 WFLLDVIAALPFDLLH-----AFKVNVYFGAHLLKTVR---LLRLLRLLPRLDRYSQY-- 355
WF++D ++++P D + VY A L+ VR +L LLRLL RL R +Y
Sbjct: 290 WFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLL-RLSRLIRYIH 348
Query: 356 -------------SAVV-LTLLMAVFALLAHWVACVWFYIGQREIESSESELPEIGWLQE 401
SAV+ + L+++ LL HW C+ F + + + P W+
Sbjct: 349 QWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQ------DFPRNCWV-- 400
Query: 402 LARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALS 461
S + N + EL Y +L+ A+S
Sbjct: 401 ----------------------------SINGMVNHSWSEL---------YSFALFKAMS 423
Query: 462 SLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDL 521
+ +G+G + + T+ ++ +M++GA +A+ G+ TA+IQ + + R Y + + +
Sbjct: 424 HMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQV 483
Query: 522 RDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIA-MHLHKEVLQL 580
Y+ H++P +Q++ +Y++ + D +L L LR +I + K V +
Sbjct: 484 EQYMSFHKLPADFRQKIHDYYEHRYQ-GKMFDEDSILGELNGPLREEIVNFNCRKLVASM 542
Query: 581 PLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILG 640
PLF A + A+ L+ PG+Y+I +G + +YF+ G + VL G L
Sbjct: 543 PLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLS 602
Query: 641 KGDLIG--CELPRREQVVKANADVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGLRG 698
G G C L R + AD TYC L L + ++ L YP F
Sbjct: 603 DGSYFGEICLLTRGRRTASVRAD----TYCRLYSLSVDNFNEVLEEYPMMRRAFETVAID 658
Query: 699 ELSYNLGAGGG----SAEVDTSS---LSGDNTLMSTL----EEKETDGEQGPTVSPAPAD 747
L +G + D +S + +N ++ + E E G V P
Sbjct: 659 RLD-RIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPP 717
Query: 748 EPSSPLLSPGCTSSSSAAKLLSPRRTAP--------RPRLGGRGRPGRAGALKAEA--GP 797
P + S T +AA P+ P PRL R PG A A + P
Sbjct: 718 PPPPQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPP 777
Query: 798 SAPPRALEGLRLP--------PMPWNVPPDLSPRVVDGIEDGCGSDQPKFSFRVGQSGPE 849
++PP A R P P P L R + + QP S G GP
Sbjct: 778 ASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQP--SLPHGAPGPA 835
Query: 850 CSSSPSPGPESGLLTVPHGPSEARNTDTLD 879
S+ P+ L P + A + D D
Sbjct: 836 ASTRPASSSTPRLGPTPAARAAAPSPDRRD 865
Score = 33.9 bits (76), Expect = 0.86
Identities = 35/129 (27%), Positives = 41/129 (31%), Gaps = 32/129 (24%)
Query: 950 QPPAGSVLSGTWPHP-------RPGPPPLMAPWPWGPPASQSSPWPRATAFWTSTSDSEP 1002
+ P + G P P +P PPP AP P PA P PRA A +D
Sbjct: 12 ESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHP-PRAEALPPEAADEGG 70
Query: 1003 P-----ASGDLCSEPSTPAS-------------------PPPSEEGARTGPAEPVSQAEA 1038
P + C P TP + P EG GP S A
Sbjct: 71 PRGRLRSRDSSCGRPGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARGPKVSFSCRGA 130
Query: 1039 TSTGEPPPG 1047
S P PG
Sbjct: 131 ASGPAPGPG 139
Score = 33.1 bits (74), Expect = 1.5
Identities = 42/154 (27%), Positives = 57/154 (37%), Gaps = 38/154 (24%)
Query: 927 CPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGTWPHPRPGPPPLMAPWPWGPPASQSSP 986
CP L+ PL + G+ +PP G + PGPPP P PP + +SP
Sbjct: 739 CPQVARPLVGPLAL--GSPRLVRRPPPGPAPAAA----SPGPPP-----PASPPGAPASP 787
Query: 987 -WPRATAFW--------------TSTSDSEPPASGDLCSEPSTP--------ASPPPSEE 1023
PR + + S + P S S+PS P ++ P S
Sbjct: 788 RAPRTSPYGGLPAAPLAGPALPARRLSRASRPLS---ASQPSLPHGAPGPAASTRPASSS 844
Query: 1024 GARTGPAEPVSQAEATSTGEPPPGSGGLALPWDP 1057
R GP P ++A A S S G A DP
Sbjct: 845 TPRLGPT-PAARAAAPSPDRRDSASPGAAGGLDP 877
Score = 31.6 bits (70), Expect = 4.2
Identities = 18/40 (45%), Positives = 20/40 (50%), Gaps = 1/40 (2%)
Query: 780 GGRGRPGRA-GALKAEAGPSAPPRALEGLRLPPMPWNVPP 818
GG GRPG + GA A P PP A + PP P PP
Sbjct: 5 GGGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPP 44
>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
potassium channel 4 [Homo sapiens]
Length = 1203
Score = 153 bits (387), Expect = 7e-37
Identities = 224/938 (23%), Positives = 365/938 (38%), Gaps = 157/938 (16%)
Query: 178 SGHLQKQ-----PKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLH-CGALRATWDGFI 231
+G +Q+Q G +K + +FG + + E + ++ + F ++H R WD +
Sbjct: 211 AGFMQRQFGAMLQPGVNKFSLRMFGSQKAV-EREQERVKSAGFWIIHPYSDFRFYWDLTM 269
Query: 232 LLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSG-Q 290
LL + + +P + + P V ++ + F++D+VLNFRT V + +
Sbjct: 270 LLLMVGNLIIIPVGITFFKDENTT----PWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTE 325
Query: 291 VVFAPKSICLHYVTTWFLLDVIAALPFDLLHAF-----KVNVYFGAHLLKTVR---LLRL 342
++ P+ I + Y+ +WF++D I+++P D + VY A L+ VR +L L
Sbjct: 326 IILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSL 385
Query: 343 LRLLPRLDRYSQY---------------SAVV-LTLLMAVFALLAHWVACVWFYIGQREI 386
LRLL RL R +Y SAVV + L+ + LL HW C+ F + +
Sbjct: 386 LRLL-RLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQ- 443
Query: 387 ESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGLELLGGP 446
+ P+ W V NS G+
Sbjct: 444 -----DFPDDCW--------------VSINNMVNNSWGKQ-------------------- 464
Query: 447 SLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQR 506
Y +L+ A+S + +G+G + ++ ++ +M++GA +A+ G+ TA+IQ
Sbjct: 465 -----YSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQS 519
Query: 507 MYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELR 566
+ + R Y + + + Y+ H++P +QR+ +Y++ + D +L L + LR
Sbjct: 520 LDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQ-GKMFDEESILGELSEPLR 578
Query: 567 ADIA-MHLHKEVLQLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSG 625
+I + K V +PLF A + ++ LR PG+Y+I +G + +YF+ G
Sbjct: 579 EEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHG 638
Query: 626 SMEVLKGGTVLAILGKGDLIG--CELPRREQVVKANADVKGLTYCVLQCLQLAGLHDSLA 683
+ VL G L G G C L R + AD TYC L L + ++ L
Sbjct: 639 VVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRAD----TYCRLYSLSVDNFNEVLE 694
Query: 684 LYPEFAPRF--------------SRGLRGELSYNLGAG---GGSAEVDTSSLSGDNTLMS 726
YP F + L ++ ++L +G E+ + D +
Sbjct: 695 EYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAH 754
Query: 727 TLEEKETDGEQGPTVSPAP-ADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRP 785
+ PT +P +PL + T+S + A PR P R P
Sbjct: 755 CAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPR----LPAAIFRPPP 810
Query: 786 GRAGALKAEAGPSAPPRALEGLR--LPPMPWNVPPDLSPRVVDGIEDGCGSDQ--PKFSF 841
G G PR L+ L+ +P + P SP VD Q FS
Sbjct: 811 GSG---LGNLGAGQTPRHLKRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSA 867
Query: 842 RVGQSGPECSSSPSPGPESGLLTVPHGPSEARNTDTLDKLRQAVTELSEQVLQMREGLQS 901
G S SSS SP P G P P+ + A T ++ + S
Sbjct: 868 PAGLSPLLPSSSSSPPP--GACGSPSAPTPSAGV--------AATTIAGFGHFHKALGGS 917
Query: 902 LRQAVQLVLAPHREGP-CPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGT 960
L + +L P + G P+A+ P P G L G + L PP S +
Sbjct: 918 LSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGL-------GLPEHFLPPPPSSRSPSS 970
Query: 961 WPHPRPGPP-PLMAPWPWGPPASQSSPWPRATAFWTSTSDSEPP-----ASGDLCSEPST 1014
P PP L GP ++ +P PR EPP ASG T
Sbjct: 971 SPGQLGQPPGELSLGLATGPLSTPETP-PR---------QPEPPSLVAGASGGASPVGFT 1020
Query: 1015 P---ASPPPSEEG-ARTGPAEPVSQAEATSTGEPPPGS 1048
P SPP G RT P+ P + + + PP S
Sbjct: 1021 PRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPAS 1058
Score = 32.0 bits (71), Expect = 3.2
Identities = 31/113 (27%), Positives = 47/113 (41%), Gaps = 7/113 (6%)
Query: 694 RGLRGELSYNLGAGGGSAEVDTSSLSGDNTLMSTLEEKE--TDGEQGPTVSPAPADEPSS 751
R RG L+ GGGS T S S L + EE+ +G+ P P +
Sbjct: 94 RRFRGSLASLGSRGGGSG--GTGSGSSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAE 151
Query: 752 PLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPGRAGALKAEAGPSAPPRAL 804
P PG ++ +A+ P + P+P +P A+K E G +A + L
Sbjct: 152 PE-RPGASAQPAASP--PPPQQPPQPASASCEQPSVDTAIKVEGGAAAGDQIL 201
>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
[Homo sapiens]
Length = 676
Score = 152 bits (385), Expect = 1e-36
Identities = 114/434 (26%), Positives = 201/434 (46%), Gaps = 54/434 (12%)
Query: 263 VCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHY-VTTWFLLDVIAALPFDLLH 321
V D + +VL++LD+++ RT F+ + G +V + HY TT F LDV++ +P DL +
Sbjct: 187 VLDYSADVLYVLDVLVRARTGFLEQ-GLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245
Query: 322 AFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVV-LTLLMAVFALLAHWVACVWFY 380
Y + ++ RL R + + Y + + L+ ++ HW AC++F
Sbjct: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFA 305
Query: 381 IGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGL 440
I + IG+ G S N S
Sbjct: 306 ISKF-----------IGF---------------------GTDSWVYPNISIPEHGR---- 329
Query: 441 ELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNV 500
L YI SLY++ +LT++G D E +F + L+G L+ A + GNV
Sbjct: 330 -------LSRKYIYSLYWSTLTLTTIGETPPPVK-DEEYLFVVVDFLVGVLIFATIVGNV 381
Query: 501 TAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQS 560
++I M A R + ++ ++ Y++ ++ K L+ R++ +F WA +D E+L+S
Sbjct: 382 GSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKS 441
Query: 561 LPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQAL 619
LPD+L+A+IA+++H + L ++ +F+ G L L L LRP +PG+Y+ +GD + +
Sbjct: 442 LPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEM 501
Query: 620 YFVCSGSMEVL--KGGTVLAILGKGDLIG----CELPRREQVVKANADVKGLTYCVLQCL 673
Y + G + V+ G T +L G G + + + A+++ + Y L CL
Sbjct: 502 YIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCL 561
Query: 674 QLAGLHDSLALYPE 687
L ++L YPE
Sbjct: 562 SKDDLMEALTEYPE 575
>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
sapiens]
Length = 694
Score = 152 bits (385), Expect = 1e-36
Identities = 114/434 (26%), Positives = 201/434 (46%), Gaps = 54/434 (12%)
Query: 263 VCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHY-VTTWFLLDVIAALPFDLLH 321
V D + +VL++LD+++ RT F+ + G +V + HY TT F LDV++ +P DL +
Sbjct: 205 VLDYSADVLYVLDVLVRARTGFLEQ-GLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 263
Query: 322 AFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVV-LTLLMAVFALLAHWVACVWFY 380
Y + ++ RL R + + Y + + L+ ++ HW AC++F
Sbjct: 264 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFA 323
Query: 381 IGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGL 440
I + IG+ G S N S
Sbjct: 324 ISKF-----------IGF---------------------GTDSWVYPNISIPEHGR---- 347
Query: 441 ELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNV 500
L YI SLY++ +LT++G D E +F + L+G L+ A + GNV
Sbjct: 348 -------LSRKYIYSLYWSTLTLTTIGETPPPVK-DEEYLFVVVDFLVGVLIFATIVGNV 399
Query: 501 TAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQS 560
++I M A R + ++ ++ Y++ ++ K L+ R++ +F WA +D E+L+S
Sbjct: 400 GSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKS 459
Query: 561 LPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQAL 619
LPD+L+A+IA+++H + L ++ +F+ G L L L LRP +PG+Y+ +GD + +
Sbjct: 460 LPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEM 519
Query: 620 YFVCSGSMEVL--KGGTVLAILGKGDLIG----CELPRREQVVKANADVKGLTYCVLQCL 673
Y + G + V+ G T +L G G + + + A+++ + Y L CL
Sbjct: 520 YIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCL 579
Query: 674 QLAGLHDSLALYPE 687
L ++L YPE
Sbjct: 580 SKDDLMEALTEYPE 593
>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
potassium channel 1 [Homo sapiens]
Length = 890
Score = 145 bits (365), Expect = 3e-34
Identities = 135/567 (23%), Positives = 244/567 (43%), Gaps = 85/567 (14%)
Query: 149 GGGRRRYGRARSKGFNANRRRSRAVLYHLSGHLQKQPKGKHKLNKGVFGEKPNLPEYKVA 208
GGG G + GF R + G +K + +FG + + E +
Sbjct: 67 GGGGGGGGEEPAGGFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAV-EKEQE 125
Query: 209 AIRKSPFILLH-CGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLA 267
++ + F ++H R WD +L+ + V +P + T + + P + ++A
Sbjct: 126 RVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTT----PWIIFNVA 181
Query: 268 VEVLFILDIVLNFRTTFVSK-SGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLH----- 321
+ +F+LD+++NFRT V++ S +++ PK I ++Y+ +WF++D I+++P D +
Sbjct: 182 SDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEK 241
Query: 322 AFKVNVYFGAHLLKTVR---LLRLLRLLPRLDRYSQY---------------SAVVLTL- 362
VY A L+ VR +L LLRLL RL R +Y SAVV
Sbjct: 242 GMDSEVYKTARALRIVRFTKILSLLRLL-RLSRLIRYIHQWEEIFHMTYDLASAVVRIFN 300
Query: 363 LMAVFALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNS 422
L+ + LL HW C+ F + + + P W+
Sbjct: 301 LIGMMLLLCHWDGCLQFLVPLLQ------DFPPDCWVS---------------------- 332
Query: 423 SGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFS 482
L + S Y +L+ A+S + +G+G + + ++ +
Sbjct: 333 -----------------LNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWIT 375
Query: 483 ICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYF 542
+ +M++GA +A+ G+ TA+IQ + + R Y + + + Y+ H++P ++Q++ +Y+
Sbjct: 376 MLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYY 435
Query: 543 QATWAVNNGIDTTELLQSLPDELRADIA-MHLHKEVLQLPLFEAASRGCLRALSLALRPA 601
+ + D +L L D LR +I + K V +PLF A + A+ LR
Sbjct: 436 EHRYQ-GKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFE 494
Query: 602 FCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIG--CELPRREQVVKAN 659
PG+Y+I +G + +YF+ G V+ + L G G C L + +
Sbjct: 495 VFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVR 554
Query: 660 ADVKGLTYCVLQCLQLAGLHDSLALYP 686
AD TYC L L + ++ L YP
Sbjct: 555 AD----TYCRLYSLSVDNFNEVLEEYP 577
>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
[Homo sapiens]
Length = 759
Score = 137 bits (344), Expect = 7e-32
Identities = 105/434 (24%), Positives = 200/434 (46%), Gaps = 54/434 (12%)
Query: 263 VCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLHA 322
+ D ++++++D+ + RT ++ + V K I + F LDV++ +P DLL+
Sbjct: 271 ILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLY- 329
Query: 323 FKVNV-YFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVV-LTLLMAVFALLAHWVACVWFY 380
FK+ Y L + +R R+ R + + Y + ++ L+ ++ HW ACV++
Sbjct: 330 FKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYS 389
Query: 381 IGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGL 440
I + IG+ GN + + +
Sbjct: 390 ISKA-----------IGF---------------------GNDTWVYPDINDPEFGR---- 413
Query: 441 ELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNV 500
L Y+ SLY++ +LT++G D+E +F + LIG L+ A + GN+
Sbjct: 414 -------LARKYVYSLYWSTLTLTTIGETPPPVR-DSEYVFVVVDFLIGVLIFATIVGNI 465
Query: 501 TAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQS 560
++I M A R + +R ++ Y+ + K +++R++++F W +D E+L+
Sbjct: 466 GSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKY 525
Query: 561 LPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQAL 619
LPD+LRA+IA+++H + L ++ +F G L L L L+P +PG+Y+ +GD + +
Sbjct: 526 LPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREM 585
Query: 620 YFVCSGSMEVL--KGGTVLAILGKGDLIG----CELPRREQVVKANADVKGLTYCVLQCL 673
Y + G + V+ G T +L G G + + + A++K + Y L CL
Sbjct: 586 YIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCL 645
Query: 674 QLAGLHDSLALYPE 687
L ++L YP+
Sbjct: 646 SKDDLMEALTEYPD 659
>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
sapiens]
Length = 690
Score = 137 bits (344), Expect = 7e-32
Identities = 105/434 (24%), Positives = 200/434 (46%), Gaps = 54/434 (12%)
Query: 263 VCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLHA 322
+ D ++++++D+ + RT ++ + V K I + F LDV++ +P DLL+
Sbjct: 202 ILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLY- 260
Query: 323 FKVNV-YFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVV-LTLLMAVFALLAHWVACVWFY 380
FK+ Y L + +R R+ R + + Y + ++ L+ ++ HW ACV++
Sbjct: 261 FKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYS 320
Query: 381 IGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGL 440
I + IG+ GN + + +
Sbjct: 321 ISKA-----------IGF---------------------GNDTWVYPDINDPEFGR---- 344
Query: 441 ELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNV 500
L Y+ SLY++ +LT++G D+E +F + LIG L+ A + GN+
Sbjct: 345 -------LARKYVYSLYWSTLTLTTIGETPPPVR-DSEYVFVVVDFLIGVLIFATIVGNI 396
Query: 501 TAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQS 560
++I M A R + +R ++ Y+ + K +++R++++F W +D E+L+
Sbjct: 397 GSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKY 456
Query: 561 LPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQAL 619
LPD+LRA+IA+++H + L ++ +F G L L L L+P +PG+Y+ +GD + +
Sbjct: 457 LPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREM 516
Query: 620 YFVCSGSMEVL--KGGTVLAILGKGDLIG----CELPRREQVVKANADVKGLTYCVLQCL 673
Y + G + V+ G T +L G G + + + A++K + Y L CL
Sbjct: 517 YIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCL 576
Query: 674 QLAGLHDSLALYPE 687
L ++L YP+
Sbjct: 577 SKDDLMEALTEYPD 590
>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
potassium channel 3 [Homo sapiens]
Length = 774
Score = 134 bits (338), Expect = 4e-31
Identities = 125/493 (25%), Positives = 213/493 (43%), Gaps = 85/493 (17%)
Query: 224 RATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTT 283
R WD +LL + + +P V ++ +E ++ P V ++ + F+LD+VLNFRT
Sbjct: 93 RFYWDLIMLLLMVGNLIVLP--VGITFFKEENSP--PWIVFNVLSDTFFLLDLVLNFRTG 148
Query: 284 FVSKSG-QVVFAPKSICLHYVTTWFLLDVIAALPFDLLHA-------FKVNVYFGAHLLK 335
V + G +++ AP++I Y+ TWFL+D+I+++P D + VY A L+
Sbjct: 149 IVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALR 208
Query: 336 TVR---LLRLLRLLPRLDRYSQY---------------SAVVLTL-LMAVFALLAHWVAC 376
VR +L LLRLL RL R +Y SAVV L+ + LL HW C
Sbjct: 209 IVRFTKILSLLRLL-RLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGC 267
Query: 377 VWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEAN 436
+ F + + + P W+
Sbjct: 268 LQFLVPMLQ------DFPPDCWVS------------------------------------ 285
Query: 437 GTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVV 496
+ + S Y +L+ A+S + +G+G + + ++ +M++GA +A+
Sbjct: 286 ---INHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMF 342
Query: 497 FGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTE 556
G+ TA+IQ + + R Y + + + Y+ H++P +QR+ EY++ + D
Sbjct: 343 IGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQ-GKMFDEES 401
Query: 557 LLQSLPDELRADIAMHLHKE-VLQLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDA 615
+L L + LR +I + V +PLF A + A+ LR PG+ ++ +G
Sbjct: 402 ILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSV 461
Query: 616 LQALYFVCSGSMEVLKGGTVLAILGKGDLIG--CELPRREQVVKANADVKGLTYCVLQCL 673
+ +YF+ G + VL G L G G C L R + AD TYC L L
Sbjct: 462 GRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRAD----TYCRLYSL 517
Query: 674 QLAGLHDSLALYP 686
+ + L +P
Sbjct: 518 SVDHFNAVLEEFP 530
Score = 34.7 bits (78), Expect = 0.50
Identities = 34/112 (30%), Positives = 40/112 (35%), Gaps = 16/112 (14%)
Query: 959 GTWPHPRPGPPPLMAPWPWGPPASQSSPW-PRATAFWTSTSDSEPPASGDLCSEPSTPA- 1016
G P P L+A W S +SP P W STS P + L + S
Sbjct: 629 GPLPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGR 688
Query: 1017 ------SPPPSEEGARTGP-------AEPVSQAEATSTGEP-PPGSGGLALP 1054
PPP G R GP ++P AT G P GSG LP
Sbjct: 689 SQVSLLGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLP 740
>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
Length = 664
Score = 131 bits (329), Expect = 4e-30
Identities = 108/435 (24%), Positives = 201/435 (46%), Gaps = 56/435 (12%)
Query: 263 VCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYV-TTWFLLDVIAALPFDLLH 321
V D +V++I D+ + RT F+ + G +V K + +Y+ T F LDV + +P DL++
Sbjct: 177 VLDYVSDVVYIADLFIRLRTGFLEQ-GLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY 235
Query: 322 AFKVNVYFG-AHLLKTVRLLRLLRLLPRLDRYSQYSAVV-LTLLMAVFALLAHWVACVWF 379
F V+++ + + R+ R + + Y + ++ L+ ++ HW AC+++
Sbjct: 236 -FAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYY 294
Query: 380 YIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTG 439
I + IG+ ++T Y P G
Sbjct: 295 AISK-----------SIGF------GVDTWVYPNITDPEYGY------------------ 319
Query: 440 LELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGN 499
L YI LY++ +LT++G D E +F I LIG L+ A + GN
Sbjct: 320 --------LAREYIYCLYWSTLTLTTIGETPPPVK-DEEYLFVIFDFLIGVLIFATIVGN 370
Query: 500 VTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQ 559
V ++I M A R + ++ ++ Y++ ++ K ++ +++ +F W +D E+L+
Sbjct: 371 VGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILK 430
Query: 560 SLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQA 618
+LP +LRA+IA+++H L ++ +F G L L L LRP +PG+Y+ +GD +
Sbjct: 431 NLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKE 490
Query: 619 LYFVCSGSMEVL--KGGTVLAILGKGDLIG----CELPRREQVVKANADVKGLTYCVLQC 672
+Y + G + V+ G T A+L G G + + + A+++ L Y L C
Sbjct: 491 MYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFC 550
Query: 673 LQLAGLHDSLALYPE 687
L L +++ YP+
Sbjct: 551 LSKDDLMEAVTEYPD 565
>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
Length = 575
Score = 126 bits (316), Expect = 1e-28
Identities = 110/440 (25%), Positives = 195/440 (44%), Gaps = 66/440 (15%)
Query: 263 VCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTW-FLLDVIAALPFDLLH 321
V D ++L++LD+V+ F T F+ + G +V I YV TW F LD+ + +P D+++
Sbjct: 71 VLDYTSDLLYLLDMVVRFHTGFLEQ-GILVVDKGRISSRYVRTWSFFLDLASLMPTDVVY 129
Query: 322 AFKVNVYFGAHL--LKTVRLLRLLRLLPRLDRYSQYSAV-----VLTLLMAVFALLAHWV 374
V G H L+ R LR RL DR +A + L++ +F ++ HW
Sbjct: 130 -----VRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVI-HWN 183
Query: 375 ACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSE 434
+C++F + + Y GR Q
Sbjct: 184 SCLYFALSR--------------------------YLGFGRDAWVYPDPAQP-------- 209
Query: 435 ANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHA 494
G LR Y+ S YF+ LT+VG A + E +F + L+ + A
Sbjct: 210 ---------GFERLRRQYLYSFYFSTLILTTVGDTPPPAREE-EYLFMVGDFLLAVMGFA 259
Query: 495 VVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDT 554
+ G+++++I M ++ ++ Y+++ + + L++R+++++Q +
Sbjct: 260 TIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNE 319
Query: 555 TELLQSLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQG 613
+LQ LP+ LRA++A+ +H L ++ +F+ L L L L+P +PGEY+ +G
Sbjct: 320 VAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKG 379
Query: 614 DALQALYFVCSGSMEVL--KGGTVLAILGKGDLIG----CELPRREQVVKANADVKGLTY 667
D Q +Y + G + V+ G T A+LG G G + + A++K L Y
Sbjct: 380 DIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGY 439
Query: 668 CVLQCLQLAGLHDSLALYPE 687
L CL L + L+ YP+
Sbjct: 440 SDLFCLSKEDLREVLSEYPQ 459
>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
sapiens]
Length = 1251
Score = 90.1 bits (222), Expect = 1e-17
Identities = 93/431 (21%), Positives = 182/431 (42%), Gaps = 62/431 (14%)
Query: 265 DLAVEVLFILDI-VLNFRTTFVSKSGQVVFAPKSICLHYVTTW-FLLDVIAALPFDLLHA 322
D ++++ LDI V R FV + G ++ K + +Y+ + F +D+++ LP D L+
Sbjct: 695 DYLCDLIYFLDITVFQTRLQFV-RGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLY- 752
Query: 323 FKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLA-HWVACVWFYI 381
KV V L + ++ + RL+ + V + + L + H +C++++
Sbjct: 753 LKVGVNPLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWA 812
Query: 382 GQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGLE 441
S+ L W+ + G G
Sbjct: 813 ------SAYQGLGSTHWVYD-----------------------------------GVG-- 829
Query: 442 LLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVT 501
++YI YFA+ +L ++G G T E +F + G +V+ G +
Sbjct: 830 --------NSYIRCYYFAVKTLITIG-GLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMR 880
Query: 502 AIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSL 561
++ A + Y S Y+ ++IPK ++ R+ +++ TW +D +EL+ L
Sbjct: 881 DVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQL 940
Query: 562 PDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALY 620
PD++R D+A+ ++ ++ ++ LF+ R + + LR P +Y+ +G+ + +Y
Sbjct: 941 PDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMY 1000
Query: 621 FVCSGSMEVL---KGGTVLAILGKGDLIG-CELPRREQVVKANADVKGLTYCVLQCLQLA 676
+ +G ++VL G +VL L G + G L + A+V + L L
Sbjct: 1001 IIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKK 1060
Query: 677 GLHDSLALYPE 687
L++ L YPE
Sbjct: 1061 DLNEILVHYPE 1071
Score = 32.0 bits (71), Expect = 3.2
Identities = 27/95 (28%), Positives = 34/95 (35%), Gaps = 10/95 (10%)
Query: 980 PASQSSPWPRATAFWT-STSDSEPPAS----GDLCSEPSTPASPPP-----SEEGARTGP 1029
P S W A T + SD PP G TP+ P P EE
Sbjct: 173 PPKSSEVWRDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPA 232
Query: 1030 AEPVSQAEATSTGEPPPGSGGLALPWDPHSLEMVL 1064
EP ++A ++ PP + W H LEM L
Sbjct: 233 PEPQPGSQAQTSSLPPTRDPARLVAWVLHRLEMAL 267
>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
Length = 809
Score = 79.3 bits (194), Expect = 2e-14
Identities = 83/392 (21%), Positives = 169/392 (43%), Gaps = 63/392 (16%)
Query: 263 VCDLAVEVLFILDIV-LNFRTTFVSKSGQVVFAPKSICLHYVT-TWFLLDVIAALPFDLL 320
+ D+ +++++ D++ + R FV + G ++ + HY T T F LDV + +PFD+
Sbjct: 255 IADIICDIIYLYDMLFIQPRLQFV-RGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDIC 313
Query: 321 HAF-KVNVYFGAH-LLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVW 378
+ F N F A+ +LK L + + V+ T +F L H ACV+
Sbjct: 314 YLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFIL--HINACVY 371
Query: 379 FYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGT 438
++ +S+ E GT
Sbjct: 372 YW-------------------------------------------------ASNYEGIGT 382
Query: 439 GLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFG 498
+ G + Y+ Y+A+ +L ++G G T E +F + G + + + G
Sbjct: 383 TRWVYDGEG--NEYLRCYYWAVRTLITIG-GLPEPQTLFEIVFQLLNFFSGVFVFSSLIG 439
Query: 499 NVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELL 558
+ +I A + + + D Y+ + IPK +++R+ +++ TW +D ++LL
Sbjct: 440 QMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLL 499
Query: 559 QSLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQ 617
++LP ++ +A+ ++ ++ ++ LF+ + + L L+ PG+++ +G+ +
Sbjct: 500 KTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGK 559
Query: 618 ALYFVCSGSMEVLKG--GT-VLAILGKGDLIG 646
+Y + G ++VL G GT VL L G + G
Sbjct: 560 EMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFG 591
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 63.2 bits (152), Expect = 1e-09
Identities = 91/363 (25%), Positives = 122/363 (33%), Gaps = 72/363 (19%)
Query: 723 TLMSTLEEKETDGEQGPTVSPAPADEPSSPLLSP-----GCTSSSSAAKLLSPRRTAPRP 777
T S + + T +G SP+P P+ P +P G + S P T P P
Sbjct: 914 TSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSP 973
Query: 778 RLGGRGRPGRAGALKAEA--------GPSAPPRALEGLRLPPMPWNVPPDLSPRVVDGIE 829
+ GG P GA A GP+ P + +G PP P SP
Sbjct: 974 K-GGPATPSPKGAPTPPAATPPSPKGGPATP--SPKGAPTPPAVTPPSPKGSPAAT---- 1026
Query: 830 DGCGSDQPKFSFRVGQSGPECSSSPSPGPESGLLTVPHG-PSEARNTDTLDKLRQAVTEL 888
F G S P ++ PSP +P G P+ T K A L
Sbjct: 1027 ----------PFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSL 1076
Query: 889 SEQVLQMREGLQSLRQAVQLVLAPHREGPCPRASGEGPCPASTSGL-LQPLCVDTGASSY 947
AP P + GP S G + P
Sbjct: 1077 KG--------------------APTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGG 1116
Query: 948 CLQPP---AGSVLSGTWPHPRPG---PPPLMAP-----WPWGPPASQSSPWPRATAFWTS 996
PP A + + T P P+ G PPP AP P P ++P P+ T+
Sbjct: 1117 LATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAP--TT 1174
Query: 997 TSDSEPPASGDLCS-----EPSTPASPPPSEEGARTGPAEPVSQAEATSTGEPPPGSGGL 1051
+ + P G L + P+TPA+ PPS +G P+ A T PP GGL
Sbjct: 1175 PAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSP--KGAPTTPAATPPSPKGGL 1232
Query: 1052 ALP 1054
A P
Sbjct: 1233 ATP 1235
Score = 58.9 bits (141), Expect = 2e-08
Identities = 79/324 (24%), Positives = 110/324 (33%), Gaps = 49/324 (15%)
Query: 739 PTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPGRAGALKAEAGPS 798
P+ S PA P G + +S+ A + S + P G G L A
Sbjct: 735 PSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSP 794
Query: 799 AP-----------PRALEGLRLPPMP-WNVPPDLSPRVVDGIEDGCGSDQPKFSFRVGQS 846
+P P +G P P N+ +SP + + SF+ +
Sbjct: 795 SPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPEN------SLSFQGSKD 848
Query: 847 GPECSSSPSPGPESGLLTVPHGPSEARNTDTLDKLRQAVTELSEQVLQMREGLQSLRQAV 906
P + SP+P G T PS AVT LS + + + V
Sbjct: 849 SPATTHSPTPPSPKGAPT----PS-------------AVTPLSPKGVTLPPKETPTPSVV 891
Query: 907 QLVLAPHREGPCPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGTWPHPRP 966
L +EGP A + P + TS + + P G S + P P
Sbjct: 892 NLPFP--KEGPATPAPKQAPALSMTSS--------SPKKARATPAPKGIPASPS-PKGAP 940
Query: 967 GPPPLMAPWPWGPPASQSSPWPRATAFWTSTSDSEPPASGDLCSEPSTPASPPPSEEGAR 1026
PP P P G PA+ S W T S PA+ P+ PA+ PPS +G
Sbjct: 941 TPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKG-- 998
Query: 1027 TGPAEPVSQAEATSTGEPPPGSGG 1050
GPA P + T PP G
Sbjct: 999 -GPATPSPKGAPTPPAVTPPSPKG 1021
Score = 56.6 bits (135), Expect = 1e-07
Identities = 87/342 (25%), Positives = 112/342 (32%), Gaps = 83/342 (24%)
Query: 737 QGPTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPR------RTAPRPRL-------GGRG 783
QG SPA P+ P SP + SA LSP+ + P P + G
Sbjct: 844 QGSKDSPATTHSPTPP--SPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPA 901
Query: 784 RPGRAGALKAEAGPSAPPRALEGLRLPPMPWNVPPDLSPRVVDGIEDGCGSDQPKFSFRV 843
P A S+P +A R P P +P SP+ G+ P +
Sbjct: 902 TPAPKQAPALSMTSSSPKKA----RATPAPKGIPASPSPK---------GAPTPPAATPP 948
Query: 844 GQSGPECSSSPSPGPESGLLTVPH---GPSEARNTDTLDKLRQAVTELSEQVLQMREGLQ 900
G + SP P T P GP+
Sbjct: 949 SPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKG------------------------ 984
Query: 901 SLRQAVQLVLAPHREGPCPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGT 960
AP P + GP S G P V + P GS +
Sbjct: 985 ----------APTPPAATPPSPKGGPATPSPKGAPTPPAVTPPS-------PKGSPAATP 1027
Query: 961 WPHPRPGPPPLMAPWPWGPPASQSSPWPRA---TAFWTSTSDSEPPASGDLCSEPSTPAS 1017
+P PP P P G PA+ +P P+ T T S PA+ L P+ PA+
Sbjct: 1028 FPKGASTPPAATPPSPKGSPAA--TPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAA 1085
Query: 1018 PPPSEEGARTGPAEPVSQ-AEATSTGEPPPGSGGLALPWDPH 1058
PPS +G GPA P + A PP GGLA P PH
Sbjct: 1086 TPPSPKG---GPATPSPKGAPMPPAATPPSPKGGLATP--PH 1122
Score = 55.1 bits (131), Expect = 4e-07
Identities = 91/342 (26%), Positives = 121/342 (35%), Gaps = 68/342 (19%)
Query: 727 TLEEKETDGEQGPTVS----PAPADEPSSPL--LSPGCTSSSSAAKLLSPRRTAPRPRLG 780
TL KET PT S P P + P++P +P + +SS+ K R P P+
Sbjct: 879 TLPPKET-----PTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPK---KARATPAPK-- 928
Query: 781 GRGRPGRAGALKAEAGPSAPPRALEGLRLPPMP-WN-VPPDLSPRVVDGIEDGCGSDQPK 838
G P A P+A P + +G P P W PP +P G G + PK
Sbjct: 929 --GIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKG---GPATPSPK 983
Query: 839 FSFRVGQSGPECSSSPSPGPESGLLTVPHGPSEARNTDTLDKLRQAVTELSEQVLQMREG 898
G P ++ PSP + P+ T K A T +
Sbjct: 984 -----GAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGAST---- 1034
Query: 899 LQSLRQAVQLVLAPHREGPCPRASGEGPCPASTSGLLQPLCVDTGASSYCLQP---PAGS 955
P P P+ S PA+T P T ++ P PA
Sbjct: 1035 ------------PPAATPPSPKGS-----PAATP---LPKGAPTTPAATLPSPKGGPATP 1074
Query: 956 VLSGTWPHPRPGPPPLMAPWPWGPPASQSSPWPRATAFWTSTSDSEPP---ASGDLCSEP 1012
L G P PP P P G PA +P P+ + + P A+ P
Sbjct: 1075 SLKGA-----PTPPAATPPSPKGGPA---TPSPKGAPMPPAATPPSPKGGLATPPHKGAP 1126
Query: 1013 STPASPPPSEEGARTGPAEPVSQAEATSTGEPPPGSGGLALP 1054
+TPA+ PPS +G P P A T PP GGLA P
Sbjct: 1127 TTPAATPPSPKGGLATP--PPKGAPTTPAATPPSPKGGLATP 1166
Score = 54.7 bits (130), Expect = 5e-07
Identities = 88/329 (26%), Positives = 118/329 (35%), Gaps = 90/329 (27%)
Query: 742 SPAPADEPSSPLLSPGCTS------SSSAAKLLSPRRTAPRPRLGGRGRPGRAGALKAEA 795
S PA P SP SP T ++ AA L SP+ P L G P A +
Sbjct: 1033 STPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKG 1092
Query: 796 GPSAPPRALEGLRLPPMPWNVPPDLSPRVVDGIEDGCGSDQPKFSFRVGQSGPECSSSPS 855
GP+ P + +G +PP PP SP+ G + K P ++
Sbjct: 1093 GPATP--SPKGAPMPPAA--TPP--SPK------GGLATPPHK-------GAPTTPAATP 1133
Query: 856 PGPESGLLTVPHGPSEARNTDTLDKLRQAVTELSEQVLQMREGLQSLRQAVQLVLAPHRE 915
P P+ GL T P P A T A T S + GL +
Sbjct: 1134 PSPKGGLATPP--PKGAPTT-------PAATPPSP-----KGGLAT-------------- 1165
Query: 916 GPCPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGTWPHPRPGPPPLMAPW 975
P G PA+T P G + + P P+ G P A
Sbjct: 1166 ---PPPKGAPTTPAATP-----------------PSPKGGLAT---PSPK-GAPTTPAAT 1201
Query: 976 PWGPPASQSSPWPRATAFWTSTSDSEPPASGDLCS-----EPSTPASPPPSEEGARTGPA 1030
P P ++P P+ T+ + + P G L + P+TPA+ PPS +G GPA
Sbjct: 1202 PPSPKGGLATPSPKGAP--TTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKG---GPA 1256
Query: 1031 EPVSQAEATSTGEPPPG-SGGLALPWDPH 1058
P + T PP GGLA P PH
Sbjct: 1257 TPPPKGAPTPPAATPPSLKGGLATP--PH 1283
Score = 53.9 bits (128), Expect = 8e-07
Identities = 83/326 (25%), Positives = 114/326 (34%), Gaps = 74/326 (22%)
Query: 737 QGPTVSPAPADEPSSPLLSP-----GCTSSSSAAKLLSPRRTAPRPRLGGRGRPGRAGAL 791
+G +P+P P++P +P G + S +P T P P+ GG P GA
Sbjct: 1206 KGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPK-GGPATPPPKGA- 1263
Query: 792 KAEAGPSAPPRALEGLRLPPMPWNVPPDLSPRVVD--GIEDGCGSDQPKFSFRVGQSGPE 849
P+A P +L+G P P +P VV + G + PK G P
Sbjct: 1264 --PTPPAATPPSLKGGLATPPHKGAP---NPAVVTPPSPKGGPATSPPK-----GAPTPP 1313
Query: 850 CSSSPSPG------PESGLLTVPH-GPSEARNTDTLDKLRQAVTELSEQVLQMREGLQSL 902
++ PSP P G T P P + T TL A T S
Sbjct: 1314 AATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLP----ATTPSS------------- 1356
Query: 903 RQAVQLVLAPHREGPCPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGTWP 962
+ GP +S EGP P P + + PP+ P
Sbjct: 1357 -----------KGGPTTPSSKEGPTP--------PAATPSHKGGPAMTPPSPK-RGPAIP 1396
Query: 963 HPRPGPPPLMAPWPWGPPASQSSPWPRATAFWTSTSDSEPPASGDLCSEPSTPAS--PPP 1020
P+ G P A P P + ++P R A S D PPA TP S P
Sbjct: 1397 SPK-GDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPA--------VTPVSLKKAP 1447
Query: 1021 SEEGARTGPAEPVSQAEATSTGEPPP 1046
+ + GPA P S+ + T PP
Sbjct: 1448 ATSAPKGGPATPSSKGDPTLPAVTPP 1473
Score = 53.5 bits (127), Expect = 1e-06
Identities = 92/338 (27%), Positives = 116/338 (34%), Gaps = 65/338 (19%)
Query: 745 PADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPGRAGALKAEAGPSAPPRAL 804
PA P SP P S A + P T P P+ GG P GA A + PP
Sbjct: 1083 PAATPPSPKGGPATPSPKGAP--MPPAATPPSPK-GGLATPPHKGAPTTPA--ATPPSPK 1137
Query: 805 EGLRLPPMPWNVP--PDLSPRVVDGIEDGCGSDQPKFSFRVGQSGPECSSSPSPGPESGL 862
GL PP P P P +P G G + PK P ++ P P+ GL
Sbjct: 1138 GGLATPP-PKGAPTTPAATPPSPKG---GLATPPPK-------GAPTTPAATPPSPKGGL 1186
Query: 863 LTV-PHG--------PSEARNTDTLDKLRQAVTELSEQVLQMREGLQSLRQAVQLVLAPH 913
T P G P + + A T + + GL + P
Sbjct: 1187 ATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLAT-PSPKGAPTTPA 1245
Query: 914 REGPCPRASGEGPCP--ASTSGLLQPLCVDTGASSYCLQPP---AGSVLSGTWPHPRPGP 968
P P+ P P A T P + G ++ PP A + T P P+ GP
Sbjct: 1246 ATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLAT----PPHKGAPNPAVVTPPSPKGGP 1301
Query: 969 ---PPLMAPWPWGPPASQSSPWPRATAFWTSTSDSEPPASGDLCSEPSTPASPPPSEEGA 1025
PP AP P P A+ SP S PP G P+ PA PPS +G
Sbjct: 1302 ATSPPKGAPTP--PAATPPSP---------KGSPGTPPPKG----APTPPAVTPPSPKGT 1346
Query: 1026 RT----------GPAEPVSQAEATSTGEPPPGSGGLAL 1053
T GP P S+ T P GG A+
Sbjct: 1347 PTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAM 1384
Score = 51.6 bits (122), Expect = 4e-06
Identities = 81/327 (24%), Positives = 112/327 (34%), Gaps = 59/327 (18%)
Query: 737 QGPTVSPAPADEPSSPLLSP-----GCTSSSSAAKLLSPRRTAPRPRLGGRGRPGRAGAL 791
+G +P P P++P +P G + S +P T P P+ GG P GA
Sbjct: 1160 KGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPK-GGLATPSPKGA- 1217
Query: 792 KAEAGPSAPPRALEGLRLPPMPWNVP--PDLSPRVVDGIEDGCGSDQPKFSFRVGQSGPE 849
P+A P + +G P P P P +P G G + PK P
Sbjct: 1218 --PTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKG---GPATPPPK-------GAPT 1265
Query: 850 CSSSPSPGPESGLLTVPH--GPSEARNTDTLDKLRQAVTELSEQVLQMREGLQSLRQAVQ 907
++ P + GL T PH P+ A T K A +
Sbjct: 1266 PPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATS--------------------- 1304
Query: 908 LVLAPHREGPCPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGTWPHPRPG 967
P + P P A+ P P + G P T + P L T P + G
Sbjct: 1305 ----PPKGAPTPPAATP-PSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGG 1359
Query: 968 PPPLMAPWPWGPPASQSSPWPRATAFWTSTSDSEPPASGDLCSEPSTPASPPPSEEGART 1027
P + PPA+ +P + T S PA +P++PA P S + A
Sbjct: 1360 PTTPSSKEGPTPPAA--TPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKA-- 1415
Query: 1028 GPAEPVSQAEATSTGEPPPGSGGLALP 1054
PA PV T G P G L P
Sbjct: 1416 -PATPV-----TREGAATPSKGDLTPP 1436
Score = 50.8 bits (120), Expect = 7e-06
Identities = 81/337 (24%), Positives = 123/337 (36%), Gaps = 47/337 (13%)
Query: 736 EQGPTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPGRAG-ALKAE 794
++GP + P+P +P+SP + P + A + R A P G P +LK
Sbjct: 1390 KRGPAI-PSPKGDPTSPAVIPLSPKKAPATPVT--REGAATPSKGDLTPPAVTPVSLKKA 1446
Query: 795 AGPSAP---PRALEGLRLPPMPWNVPPDLSPRVVDGIEDGCGSDQPKFSFRVGQSGPECS 851
SAP P P +P PP SP+ + S PK +
Sbjct: 1447 PATSAPKGGPATPSSKGDPTLPAVTPP--SPKEPPAPKQVATSSSPK----------KAP 1494
Query: 852 SSPSP-GPESGLLTVPHGPSEARNTDTL--DKLRQAVTELSEQVLQMREGLQSLRQAVQL 908
++P+P G + +P P E T + D + T LS++ ++L
Sbjct: 1495 ATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEAL------ 1548
Query: 909 VLAPHREGPCPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGTWPHPRPGP 968
+ P P P+ + P P T +S PPA V T+ P P
Sbjct: 1549 -IPPAMTVPSPKKTPAIPTPKEAPA--------TPSSKEASSPPA--VTPSTYKGA-PSP 1596
Query: 969 PPLMAPWPWGPPASQSSPWPRATAFWTSTSDSEPPASGDLCSEPSTPASPPPSEEGARTG 1028
L+ P P+ + +P P A T S + PA+ + TP SPP + +
Sbjct: 1597 KELLIPPAVTSPSPKEAPTPPAV---TPPSPEKGPATP---APKGTPTSPPVTPSSLKDS 1650
Query: 1029 PAEPVSQAEATSTGEPPPGSGGLALPWDPHSLEMVLI 1065
P P S P S GL P +L+ VL+
Sbjct: 1651 PTSPAS-VTCKMGATVPQASKGLPAKKGPTALKEVLV 1686
Score = 43.5 bits (101), Expect = 0.001
Identities = 86/352 (24%), Positives = 128/352 (36%), Gaps = 44/352 (12%)
Query: 739 PTVSPAPA-----DEPSSPLLSPGCTSSSSAAK--LLSPRRTAPRPRLGGRGRPGRAGAL 791
PT APA + S P ++P + + K L+ P T+P P+ P
Sbjct: 1565 PTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPT--PPAVTPP 1622
Query: 792 KAEAGPSAPPRALEGLRLPPMPWNVPPDL--SPRVVDGIEDGCGSDQPKFSFRV-GQSGP 848
E GP+ P A +G P P P L SP + G+ P+ S + + GP
Sbjct: 1623 SPEKGPATP--APKGT--PTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGP 1678
Query: 849 ECSSSP--SPGPESG-LLTVP--HGPSEARNTDTLDKLRQAVTELSEQVLQMREGLQSLR 903
+P PES ++T P GP +++ T + + + + +
Sbjct: 1679 TALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPL 1738
Query: 904 QAVQLVLAPHREGPCPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGTWPH 963
VQ + +G S +GP S PL T A+ + P S P
Sbjct: 1739 LPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPL---TAAAFEKVLPKPESASVSAAPS 1795
Query: 964 PRPGPPPLMAPWPWGPPASQSSPWPRATAFWTSTSDSEPPASGDLCSEPSTPASPPPSEE 1023
P P +P P PP Q P S P G + PS P +P +E
Sbjct: 1796 PPVSLPLAPSPVPTLPPKQQFLP-------------SSP---GLVLESPSKPLAPADEDE 1839
Query: 1024 GARTGPAEPVSQA---EATSTGEPPPGSGGLALPWDPHSLEMVLIGCHGSGT 1072
P EP+S ++ P P S G+ +P P + + V GSGT
Sbjct: 1840 LLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVP-TPSAKQPVTKNNKGSGT 1890
>gi|41281612 zinc finger protein 828 [Homo sapiens]
Length = 812
Score = 62.0 bits (149), Expect = 3e-09
Identities = 86/332 (25%), Positives = 125/332 (37%), Gaps = 46/332 (13%)
Query: 738 GPTVSP-APADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPGRAGALKAEAG 796
G +SP +P P +PL ++SP P P P + ++ +
Sbjct: 138 GSVLSPESPKPTPLTPL------EPQKPGSVVSPELQTPLPS----PEPSKPASVSSPEP 187
Query: 797 PSAPPRALEGLRLPPMPWNVPPDLSPRVVDGIEDGCGSDQPKFSFRVGQS-GPECSSSPS 855
P + P E +L P+P P +P + ++ + +P+ ++ GP +SSP
Sbjct: 188 PKSVP-VCESQKLAPVPSPEPQKPAPVSPESVKATLSNPKPQKQSHFPETLGPPSASSPE 246
Query: 856 PGPESGLLTVPHGPSEARNTDTLDKLRQAVTELSEQVLQMREGLQSLRQAVQLVLAPHRE 915
P P GPS A + ++ R E + E + + + P R
Sbjct: 247 -SPVLAASPEPWGPSPAASPESRKSARTTSPEPRKP--SPSESPEPWKPFPAVSPEPRRP 303
Query: 916 GPCPRASGEGPCPASTSGLLQPLCVDTGASSYCLQP--PAGSVLSGTWPHPRPGPPPLMA 973
P P P G +P + ASS +P PA SV G W P P ++
Sbjct: 304 APAVSPGSWKPGPP---GSPRPWKSNPSASSGPWKPAKPAPSVSPGPWK-----PIPSVS 355
Query: 974 PWPWGPPASQSSPWPRATAFWTSTSDSEPPASGDLCSEPSTPASPPPSEEGARTGPAEPV 1033
P PW P S SS A W S+S S PS+ SPP S E ++GP E
Sbjct: 356 PGPWKPTPSVSS------ASWKSSSVS-----------PSSWKSPPASPESWKSGPPELR 398
Query: 1034 SQAEATSTGE---PPPGSGGLALPWDPHSLEM 1062
A S PP S L P P S E+
Sbjct: 399 KTAPTLSPEHWKAVPPVSPELRKPGPPLSPEI 430
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
Length = 816
Score = 60.5 bits (145), Expect = 9e-09
Identities = 93/341 (27%), Positives = 121/341 (35%), Gaps = 62/341 (18%)
Query: 742 SPAPADEPSSP--LLSPGCTS-SSSAAKLLSPRRTAPRPRLGGRGRPGRAGALKAEAGPS 798
SPA PS+ L P S SSSA L SP R+ P R G +A A PS
Sbjct: 212 SPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSAR----------GTPRAPAHPS 261
Query: 799 AP-PRALEGLRLPPMPWNVPP--DLSPRVVDGIEDGCGSDQPKFSFRVGQSGPECSSSPS 855
P P+ L+ LR P + PP D +P + G S P + P S+ PS
Sbjct: 262 QPKPKGLQALRPPQV---TPPRKDAAPAL------GPLSSSPLAT-------PSPSAPPS 305
Query: 856 PGPESGLLTVPHGPSEARNTDTLDKLRQAVTELSEQVLQMREGLQSLRQAVQLVLAPHRE 915
P L T+P P+ + QA T L LQ L P +
Sbjct: 306 PSAPPSLQTLPSPPATPPS--------QATTSLGSPTLQATHSFLPSPPLSPLATPPPQA 357
Query: 916 GPC---PRASGEGPCPASTSGLLQPLCVDTGASSYCL---------QPPAGSVLSGTWPH 963
P P PAS L PL + + L PP + +
Sbjct: 358 PPALALPPLQAPPSPPASPP--LSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSP 415
Query: 964 PRPGP------PPLMAPWPWGPPASQSSPWPRATAFWTSTSDSEPPASGDLCSEPSTPAS 1017
P P PP AP P Q P P A+ + ++ P A L + P A
Sbjct: 416 PASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAK 475
Query: 1018 PPPSEEGA-RTGPAEPVSQAEATSTGEPPPGSGGLALPWDP 1057
PPP A T P + + A+ G+ P S +LP P
Sbjct: 476 PPPQAPPALATPPLQALPSPPASFPGQ-APFSPSASLPMSP 515
Score = 47.4 bits (111), Expect = 7e-05
Identities = 90/359 (25%), Positives = 123/359 (34%), Gaps = 45/359 (12%)
Query: 715 TSSLSGDNTLMSTLEEKETDGEQGPTVSPAPADEPSSPLLSPGCTSSSSAAKLLS--PRR 772
T S N L L + P V AP P+SP +SP T S A L+ P +
Sbjct: 383 TPSPQAPNALAVHLLQAPFSPPPSPPVQ-APFSPPASPPVSPSATPPSQAPPSLAAPPLQ 441
Query: 773 TAPRPRLGGRGRPGRAGALKAEAGPSAPPRALEGLRLPPMPWNVPPDLSPRVVDGIEDGC 832
P P P +A +APP L+L P PP L+ + +
Sbjct: 442 VPPSPPASPPMSPSATPPPQAPPPLAAPP-----LQLAKPPPQAPPALATPPLQALPSPP 496
Query: 833 GSDQPKFSFRVGQSGPECSSSPSPGPESG------LLTVPHGPSEARNTDTLDKLRQAVT 886
S + F S P S +P P++ LL VP P + TL R+ T
Sbjct: 497 ASFPGQAPFSPSASLP-MSPLATPPPQAPPVLAAPLLQVPPSPPAS---PTLQAPRRPPT 552
Query: 887 ELSEQVLQMREGLQSLRQAVQLVLAPHREGPCPRASGE--------GPCPASTSGLLQPL 938
+ + + L LAP P R+ G ++TS +
Sbjct: 553 PGPDTSVS--------GPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELR 604
Query: 939 CVDTGASS-YCLQPPAGSVLSGTWPHP--RPGPPPLM------APWPWGPPASQSSPWPR 989
D+G PP + L+ P R PPL AP PW P S
Sbjct: 605 GYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGL 664
Query: 990 ATAFWTSTSDSEPPASGDLCSEPSTPASPPPSEEGARTGPAEPVSQAEATSTGEPPPGS 1048
T + T +S PA G L PS S + GA G + + GE P G+
Sbjct: 665 CTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASS--RSPKQARLGELPLGA 721
Score = 30.4 bits (67), Expect = 9.5
Identities = 39/140 (27%), Positives = 48/140 (34%), Gaps = 24/140 (17%)
Query: 919 PRASGEG-PCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGTWPH--PRPGP-----PP 970
PR G P P T L+ L L AG + T P PR GP PP
Sbjct: 27 PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPP 86
Query: 971 LMAPWPWGPPASQSSPWPRATAFWTSTSDSEPPASGDLCSEPSTPASPPPSEEGARTGPA 1030
PPA +SP P S ASG T P ++G R
Sbjct: 87 ASGRGERAPPAKNTSPGP---------VSSPGRASG-------TTRPGPLGQKGLRISAE 130
Query: 1031 EPVSQAEATSTGEPPPGSGG 1050
E V++ +AT + S G
Sbjct: 131 ETVARGKATEAPKRSALSAG 150
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,933,597
Number of Sequences: 37866
Number of extensions: 2866718
Number of successful extensions: 24340
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 148
Number of HSP's successfully gapped in prelim test: 1160
Number of HSP's that attempted gapping in prelim test: 16873
Number of HSP's gapped (non-prelim): 6471
length of query: 1083
length of database: 18,247,518
effective HSP length: 113
effective length of query: 970
effective length of database: 13,968,660
effective search space: 13549600200
effective search space used: 13549600200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.