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Search of human proteins with 124301196
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo
sapiens]
(640 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo sapi... 1341 0.0
gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo sapi... 416 e-116
gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2 ... 344 1e-94
gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3 ... 344 1e-94
gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [H... 344 1e-94
gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2 ... 285 7e-77
gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1... 285 7e-77
gi|34452695 amiloride-sensitive cation channel 1, neuronal isofo... 154 2e-37
gi|9998944 amiloride-sensitive cation channel 1, neuronal isofor... 152 7e-37
gi|21536349 amiloride-sensitive cation channel 2, neuronal isofo... 141 2e-33
gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo... 134 2e-31
gi|31442761 amiloride-sensitive cation channel 5, intestinal [Ho... 129 6e-30
gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo... 126 5e-29
gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo ... 123 6e-28
gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo ... 123 6e-28
gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo ... 123 6e-28
gi|21536351 amiloride-sensitive cation channel 2, neuronal isofo... 121 2e-27
gi|239757391 PREDICTED: hypothetical protein XP_002345269 [Homo ... 36 0.12
gi|239751897 PREDICTED: hypothetical protein XP_002348038 [Homo ... 36 0.12
gi|239746387 PREDICTED: hypothetical protein XP_002343741 [Homo ... 36 0.12
gi|118402590 myosin XV [Homo sapiens] 33 1.1
gi|102468717 mediator complex subunit 13 [Homo sapiens] 32 2.3
gi|148922900 general transcription factor IIH, polypeptide 2B [H... 31 3.1
gi|6681762 general transcription factor IIH, polypeptide 2, 44kD... 31 3.1
gi|148922852 general transcription factor IIH, polypeptide 2C [H... 31 4.0
gi|109809737 general transcription factor IIH, polypeptide 2D [H... 31 4.0
gi|237649117 renalase isoform 1 [Homo sapiens] 30 5.2
gi|56549694 enabled homolog isoform a [Homo sapiens] 30 5.2
gi|39930375 enabled homolog isoform b [Homo sapiens] 30 5.2
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 30 5.2
>gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo
sapiens]
Length = 640
Score = 1341 bits (3471), Expect = 0.0
Identities = 640/640 (100%), Positives = 640/640 (100%)
Query: 1 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPKKKAMWFLLTLLFA 60
MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPKKKAMWFLLTLLFA
Sbjct: 1 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPKKKAMWFLLTLLFA 60
Query: 61 ALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELME 120
ALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELME
Sbjct: 61 ALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELME 120
Query: 121 AVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSAS 180
AVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSAS
Sbjct: 121 AVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSAS 180
Query: 181 EKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSY 240
EKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSY
Sbjct: 181 EKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSY 240
Query: 241 PGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILD 300
PGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILD
Sbjct: 241 PGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILD 300
Query: 301 IGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSP 360
IGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSP
Sbjct: 301 IGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSP 360
Query: 361 CTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDF 420
CTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDF
Sbjct: 361 CTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDF 420
Query: 421 PDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERD 480
PDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERD
Sbjct: 421 PDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERD 480
Query: 481 QSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEF 540
QSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEF
Sbjct: 481 QSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEF 540
Query: 541 GEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPN 600
GEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPN
Sbjct: 541 GEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPN 600
Query: 601 TGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI 640
TGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI
Sbjct: 601 TGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEGDAI 640
>gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo
sapiens]
Length = 649
Score = 416 bits (1068), Expect = e-116
Identities = 228/623 (36%), Positives = 340/623 (54%), Gaps = 30/623 (4%)
Query: 21 TYKELLVWYCDNTNTHGPKRIICE-GPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWEV 79
T KEL+ WYC NTNTHG +RI+ G ++ +W TL AL+ WQ + + ++ + V
Sbjct: 24 TIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAVALILWQCALLVFSF--YTV 81
Query: 80 SVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERILA-PELSHANATR 138
SVS+ V F+ +DFPAVTICN +P+KYS ++HLL DL++ L+ + PE
Sbjct: 82 SVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAE 141
Query: 139 NLN---------FSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSS---SASEKICNA 186
+ N FS + PL++ D+ D F + S AS +
Sbjct: 142 SWNSVSEGKQPRFS--HRIPLLIFDQ--DEKGKARDFFTGRKRKVGGSIIHKASNVMHIE 197
Query: 187 HGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSYPGEQMI 246
+ +LCS + + C F+S A+ EWY L NI AQVP ++ + MSY E+++
Sbjct: 198 SKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELL 257
Query: 247 LACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDY 306
+ C F C+ RNFT +P +GNCY FN E L ++ G+E+GL++IL I +E+Y
Sbjct: 258 VTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEY 317
Query: 307 VPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGS 366
PFL S+ G ++++H Q YPF+ D G + TSIG+ + + ++ EPYS CT +GS
Sbjct: 318 NPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGS 377
Query: 367 EVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDFPDWAHC 426
+VP++N YN YS+Q CL SCFQ M+ C C Y PLP YCN + P+W +C
Sbjct: 378 DVPIRNI---YNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYC 434
Query: 427 YSDLQMSVAQRET-CIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNI 485
Y L + Q E C +CKE+C+ ++ +T S+A WPS SE W+ VL+ ++ + N
Sbjct: 435 YYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNK 494
Query: 486 TLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIII 545
L++ + KL I++++ N R+I ES AN+I LLSN GGQ G WM SV+C+IE II
Sbjct: 495 KLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIE----II 550
Query: 546 DFVWITIIKLVALAKSLRQRRAQASYAGPP-PTVAELVEAHTNFGFQ-PDTAPRSPNTGP 603
+ +I ++A + + + A PP P + N D P +
Sbjct: 551 EVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALDIDDDLPTFNSALH 610
Query: 604 YPSEQALPIPGTPPPNYDSLRLQ 626
P +PGTPPP Y++LRL+
Sbjct: 611 LPPALGTQVPGTPPPKYNTLRLE 633
>gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2
[Homo sapiens]
Length = 728
Score = 344 bits (883), Expect = 1e-94
Identities = 198/624 (31%), Positives = 317/624 (50%), Gaps = 43/624 (6%)
Query: 21 TYKELLVWYCDNTNTHGPKRIICE--GPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWE 78
+Y+EL ++C+NT HG R++C K A W +L L ++ WQ+G+ Y S+
Sbjct: 113 SYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYP 172
Query: 79 VSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERI-----LAPELSH 133
VS+++++ + FPAVTIC +P++Y +IK L++LD + E L + ++
Sbjct: 173 VSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAG 232
Query: 134 ANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSASEKICNAH------ 187
+ + R+L ++ PH L + H + S + + + +
Sbjct: 233 SRSRRDLRGTL-------------PHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWK 279
Query: 188 GCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQ-ELVEMSYPGEQMI 246
K+ +LC+ N++ C ++ ++S A+ EWY NI +++P+ +E G I
Sbjct: 280 DWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGN-FI 338
Query: 247 LACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDY 306
AC F CN N++ +P YGNCY FN S+ PG GL L+L Q D+
Sbjct: 339 FACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDF 398
Query: 307 VPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGS 366
+P L++ G R+M+H Q F+ D G G ETSI + + L R+G Y CT NGS
Sbjct: 399 IPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGS 458
Query: 367 EVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDFPDWAHC 426
+VPV+N Y + Y+ Q C+ SCFQ+ MI+ C C + YP P+ +YC+ R W +C
Sbjct: 459 DVPVENLYP---SKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYC 515
Query: 427 YSDLQMSVAQRET-CIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNI 485
Y LQ+ + C C++ C+ T Y+++ + WPS S++W+F +LS++ + + N
Sbjct: 516 YYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVN- 574
Query: 486 TLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIII 545
R G+ K+NI+F+E NY+T ES + +V LLSNLG Q+ W G SVL ++E E++
Sbjct: 575 -NKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVF 633
Query: 546 DFVWITIIKLVALAKSLRQRRAQASYAG-PPPTVAELVEAHTNFGFQPDTAPRS-PNTGP 603
D + +I + L + R R G VA + + F P S GP
Sbjct: 634 D---LLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGP 690
Query: 604 YPSEQALPIPGTPPPNYDSLRLQP 627
PS P PPP Y +L +P
Sbjct: 691 APS----PALTAPPPAYATLGPRP 710
>gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3
[Homo sapiens]
Length = 692
Score = 344 bits (883), Expect = 1e-94
Identities = 198/624 (31%), Positives = 317/624 (50%), Gaps = 43/624 (6%)
Query: 21 TYKELLVWYCDNTNTHGPKRIICE--GPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWE 78
+Y+EL ++C+NT HG R++C K A W +L L ++ WQ+G+ Y S+
Sbjct: 77 SYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYP 136
Query: 79 VSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERI-----LAPELSH 133
VS+++++ + FPAVTIC +P++Y +IK L++LD + E L + ++
Sbjct: 137 VSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAG 196
Query: 134 ANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSASEKICNAH------ 187
+ + R+L ++ PH L + H + S + + + +
Sbjct: 197 SRSRRDLRGTL-------------PHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWK 243
Query: 188 GCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQ-ELVEMSYPGEQMI 246
K+ +LC+ N++ C ++ ++S A+ EWY NI +++P+ +E G I
Sbjct: 244 DWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGN-FI 302
Query: 247 LACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDY 306
AC F CN N++ +P YGNCY FN S+ PG GL L+L Q D+
Sbjct: 303 FACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDF 362
Query: 307 VPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGS 366
+P L++ G R+M+H Q F+ D G G ETSI + + L R+G Y CT NGS
Sbjct: 363 IPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGS 422
Query: 367 EVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDFPDWAHC 426
+VPV+N Y + Y+ Q C+ SCFQ+ MI+ C C + YP P+ +YC+ R W +C
Sbjct: 423 DVPVENLYP---SKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYC 479
Query: 427 YSDLQMSVAQRET-CIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNI 485
Y LQ+ + C C++ C+ T Y+++ + WPS S++W+F +LS++ + + N
Sbjct: 480 YYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVN- 538
Query: 486 TLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIII 545
R G+ K+NI+F+E NY+T ES + +V LLSNLG Q+ W G SVL ++E E++
Sbjct: 539 -NKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVF 597
Query: 546 DFVWITIIKLVALAKSLRQRRAQASYAG-PPPTVAELVEAHTNFGFQPDTAPRS-PNTGP 603
D + +I + L + R R G VA + + F P S GP
Sbjct: 598 D---LLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGP 654
Query: 604 YPSEQALPIPGTPPPNYDSLRLQP 627
PS P PPP Y +L +P
Sbjct: 655 APS----PALTAPPPAYATLGPRP 674
>gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [Homo
sapiens]
Length = 669
Score = 344 bits (883), Expect = 1e-94
Identities = 198/624 (31%), Positives = 317/624 (50%), Gaps = 43/624 (6%)
Query: 21 TYKELLVWYCDNTNTHGPKRIICE--GPKKKAMWFLLTLLFAALVCWQWGIFIRTYLSWE 78
+Y+EL ++C+NT HG R++C K A W +L L ++ WQ+G+ Y S+
Sbjct: 54 SYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYP 113
Query: 79 VSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERI-----LAPELSH 133
VS+++++ + FPAVTIC +P++Y +IK L++LD + E L + ++
Sbjct: 114 VSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAG 173
Query: 134 ANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSASEKICNAH------ 187
+ + R+L ++ PH L + H + S + + + +
Sbjct: 174 SRSRRDLRGTL-------------PHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWK 220
Query: 188 GCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQ-ELVEMSYPGEQMI 246
K+ +LC+ N++ C ++ ++S A+ EWY NI +++P+ +E G I
Sbjct: 221 DWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGN-FI 279
Query: 247 LACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDY 306
AC F CN N++ +P YGNCY FN S+ PG GL L+L Q D+
Sbjct: 280 FACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDF 339
Query: 307 VPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGS 366
+P L++ G R+M+H Q F+ D G G ETSI + + L R+G Y CT NGS
Sbjct: 340 IPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGS 399
Query: 367 EVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDFPDWAHC 426
+VPV+N Y + Y+ Q C+ SCFQ+ MI+ C C + YP P+ +YC+ R W +C
Sbjct: 400 DVPVENLYP---SKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYC 456
Query: 427 YSDLQMSVAQRET-CIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNI 485
Y LQ+ + C C++ C+ T Y+++ + WPS S++W+F +LS++ + + N
Sbjct: 457 YYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVN- 515
Query: 486 TLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIII 545
R G+ K+NI+F+E NY+T ES + +V LLSNLG Q+ W G SVL ++E E++
Sbjct: 516 -NKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVF 574
Query: 546 DFVWITIIKLVALAKSLRQRRAQASYAG-PPPTVAELVEAHTNFGFQPDTAPRS-PNTGP 603
D + +I + L + R R G VA + + F P S GP
Sbjct: 575 D---LLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGP 631
Query: 604 YPSEQALPIPGTPPPNYDSLRLQP 627
PS P PPP Y +L +P
Sbjct: 632 APS----PALTAPPPAYATLGPRP 651
>gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2
[Homo sapiens]
Length = 638
Score = 285 bits (730), Expect = 7e-77
Identities = 176/605 (29%), Positives = 283/605 (46%), Gaps = 54/605 (8%)
Query: 21 TYKELLVWYCDNTNTHGPKRIICEGPK--KKAMWFLLTLLFAALVCWQWGIFIRTYLSWE 78
+++ELL ++C N HG R++C K W LL+L +CWQ G+ +
Sbjct: 55 SFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRP 114
Query: 79 VSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHANATR 138
V +++SV + P VT+C+ +P + S + L+ LDE ++ + LS A
Sbjct: 115 VLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAA- 173
Query: 139 NLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSL 198
L+ ++ H P +D + L +H+G ++ RLC+
Sbjct: 174 -LSATVPRHEPPFHLDRE-------IRLQRLSHSGSR-------------VRVGFRLCNS 212
Query: 199 NRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNY 258
C +R +TS A+ +WY +I A +P +L+C + C
Sbjct: 213 TGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQA 272
Query: 259 RNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRL 318
R F + +P YG+CY + T + PG G+ L+L + Q+ ++P L++ AG+R+
Sbjct: 273 RQFRTFHHPTYGSCYTVDGVWTAQ-----RPGITHGVGLVLRVEQQPHLPLLSTLAGIRV 327
Query: 319 MLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYN 378
M+H + PF+ GTE +I + D++ R+G PY CT G V V+ + N
Sbjct: 328 MVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLH---N 384
Query: 379 TTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSV-AQR 437
T+Y+ QACL SCFQ M+ C+CG+YL+PLP G +YC++ P W HC+ L + R
Sbjct: 385 TSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHR 444
Query: 438 ETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNI 497
C C C ++ +K++ + WPS S W L E+ R + K+NI
Sbjct: 445 LPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLG-EQGLPHQSHRQRSSLAKINI 503
Query: 498 YFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVA 557
+QE NYR++EE+ ++ LLS +G W G SVL L+E E+++D +T++
Sbjct: 504 VYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLV---- 559
Query: 558 LAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPNTG-----PYPSEQALP- 611
R RRA S+ P A +P+ + P G P PS LP
Sbjct: 560 -LGGRRLRRAWFSWPRASP-------ASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPR 611
Query: 612 --IPG 614
+PG
Sbjct: 612 VMLPG 616
>gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1
[Homo sapiens]
Length = 704
Score = 285 bits (730), Expect = 7e-77
Identities = 176/605 (29%), Positives = 283/605 (46%), Gaps = 54/605 (8%)
Query: 21 TYKELLVWYCDNTNTHGPKRIICEGPK--KKAMWFLLTLLFAALVCWQWGIFIRTYLSWE 78
+++ELL ++C N HG R++C K W LL+L +CWQ G+ +
Sbjct: 121 SFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRP 180
Query: 79 VSVSLSVGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHANATR 138
V +++SV + P VT+C+ +P + S + L+ LDE ++ + LS A
Sbjct: 181 VLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAA- 239
Query: 139 NLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSL 198
L+ ++ H P +D + L +H+G ++ RLC+
Sbjct: 240 -LSATVPRHEPPFHLDRE-------IRLQRLSHSGSR-------------VRVGFRLCNS 278
Query: 199 NRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNY 258
C +R +TS A+ +WY +I A +P +L+C + C
Sbjct: 279 TGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQA 338
Query: 259 RNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRL 318
R F + +P YG+CY + T + PG G+ L+L + Q+ ++P L++ AG+R+
Sbjct: 339 RQFRTFHHPTYGSCYTVDGVWTAQ-----RPGITHGVGLVLRVEQQPHLPLLSTLAGIRV 393
Query: 319 MLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYN 378
M+H + PF+ GTE +I + D++ R+G PY CT G V V+ + N
Sbjct: 394 MVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLH---N 450
Query: 379 TTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSV-AQR 437
T+Y+ QACL SCFQ M+ C+CG+YL+PLP G +YC++ P W HC+ L + R
Sbjct: 451 TSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHR 510
Query: 438 ETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNI 497
C C C ++ +K++ + WPS S W L E+ R + K+NI
Sbjct: 511 LPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLG-EQGLPHQSHRQRSSLAKINI 569
Query: 498 YFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVA 557
+QE NYR++EE+ ++ LLS +G W G SVL L+E E+++D +T++
Sbjct: 570 VYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLV---- 625
Query: 558 LAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPNTG-----PYPSEQALP- 611
R RRA S+ P A +P+ + P G P PS LP
Sbjct: 626 -LGGRRLRRAWFSWPRASP-------ASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPR 677
Query: 612 --IPG 614
+PG
Sbjct: 678 VMLPG 682
>gi|34452695 amiloride-sensitive cation channel 1, neuronal isoform
1 [Homo sapiens]
Length = 563
Score = 154 bits (389), Expect = 2e-37
Identities = 100/356 (28%), Positives = 171/356 (48%), Gaps = 26/356 (7%)
Query: 243 EQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKAL-PSANPGTEFGLKLILDI 301
E M+L+C + E C NF+S+F YG CY+FN G K L + GT GL+++LDI
Sbjct: 216 EDMLLSCKYRGELCGPHNFSSVF-TKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDI 274
Query: 302 GQEDYVPFLAST------AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMG 355
Q++Y+P T AGV++ +H Q PFI++ G G +T + +L +
Sbjct: 275 QQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLP 334
Query: 356 EPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYC 415
P+ C SE+ + D+ YSI AC C +++ NCNC + +P +C
Sbjct: 335 PPWGEC--RSSEMGL-----DFFPVYSITACRIDCETRYIVENCNCR--MVHMPGDAPFC 385
Query: 416 NNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVL 475
+ A L +A++++ +C+ CN T+Y +SM PS+ S ++
Sbjct: 386 TPEQHKECAEPALGL---LAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYL---- 438
Query: 476 SQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVL 535
E+ + + + I+ L+I+F+ NY TIE+ A + LL ++GGQ G ++G S+L
Sbjct: 439 --EKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASIL 496
Query: 536 CLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQ 591
++E + I + + ++ L+ + S P +E + N Q
Sbjct: 497 TILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISHTVNVPLQ 552
>gi|9998944 amiloride-sensitive cation channel 1, neuronal isoform 2
[Homo sapiens]
Length = 512
Score = 152 bits (385), Expect = 7e-37
Identities = 98/356 (27%), Positives = 172/356 (48%), Gaps = 26/356 (7%)
Query: 243 EQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKAL-PSANPGTEFGLKLILDI 301
+ M+L C F + C +++FT++F YG CY+FN G K L + GT GL+++LDI
Sbjct: 165 KDMMLYCKFKGQECGHQDFTTVF-TKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDI 223
Query: 302 GQEDYVPFLAST------AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMG 355
Q++Y+P T AGV++ +H Q PFI++ G G +T + +L +
Sbjct: 224 QQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLP 283
Query: 356 EPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYC 415
P+ C SE+ + D+ YSI AC C +++ NCNC + +P +C
Sbjct: 284 PPWGEC--RSSEMGL-----DFFPVYSITACRIDCETRYIVENCNCR--MVHMPGDAPFC 334
Query: 416 NNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVL 475
+ A L +A++++ +C+ CN T+Y +SM PS+ S ++
Sbjct: 335 TPEQHKECAEPALGL---LAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYL---- 387
Query: 476 SQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVL 535
E+ + + + I+ L+I+F+ NY TIE+ A + LL ++GGQ G ++G S+L
Sbjct: 388 --EKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASIL 445
Query: 536 CLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAGPPPTVAELVEAHTNFGFQ 591
++E + I + + ++ L+ + S P +E + N Q
Sbjct: 446 TILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISHTVNVPLQ 501
>gi|21536349 amiloride-sensitive cation channel 2, neuronal isoform
b [Homo sapiens]
Length = 528
Score = 141 bits (355), Expect = 2e-33
Identities = 98/335 (29%), Positives = 161/335 (48%), Gaps = 29/335 (8%)
Query: 245 MILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKA-LPSANPGTEFGLKLILDIGQ 303
M+L+C F E C+ +F +F YG CY FN G + L + GT GL+++LDI Q
Sbjct: 168 MLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQ 226
Query: 304 EDYVPFLAST------AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEP 357
++Y+P T AG+++ +H Q PFI G G +T + +L + P
Sbjct: 227 DEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPP 286
Query: 358 YSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNN 417
+ C + + D+ +YSI AC C +++ NCNC + +P YC
Sbjct: 287 WGTCKAVTMDSDL-----DFFDSYSITACRIDCETRYLVENCNCR--MVHMPGDAPYCTP 339
Query: 418 RDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQ 477
+ + A D + Q E C+ C+ CN T+Y +SM PS+AS ++ ++
Sbjct: 340 EQYKECADPALDFLVEKDQ-EYCV--CEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK 396
Query: 478 ERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCL 537
+ I+ L+I+F+ NY TIE+ A I LL ++GGQ G ++G S+L +
Sbjct: 397 SEQYIG------ENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTV 450
Query: 538 IEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYA 572
+E + D+ + +IK + Q+ A+ S A
Sbjct: 451 LE----LFDYAY-EVIKHKLCRRGKCQKEAKRSSA 480
Score = 35.0 bits (79), Expect = 0.21
Identities = 27/93 (29%), Positives = 46/93 (49%), Gaps = 8/93 (8%)
Query: 48 KKAMW---FLLTLLFAALVCWQWGIFIRTYLSWEVSVSLS-VGFKTMDFPAVTICNASPF 103
K+A+W FL +L VC + ++ Y + L V + FPAVT+CN + F
Sbjct: 42 KRALWALCFLGSLAVLLCVCTER---VQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEF 98
Query: 104 KYSKI-KHLLKDLDELMEAVLERILAPELSHAN 135
++S++ K+ L EL+ + R P+ A+
Sbjct: 99 RFSQVSKNDLYHAGELLALLNNRYEIPDTQMAD 131
>gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo
sapiens]
Length = 666
Score = 134 bits (338), Expect = 2e-31
Identities = 104/384 (27%), Positives = 174/384 (45%), Gaps = 53/384 (13%)
Query: 192 AMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFA--------------QVPQQELVE 237
A+ LC++NR FR+ AL++ I N+ + P+ ++V+
Sbjct: 241 AVTLCNINR----FRH-----SALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVD 291
Query: 238 -MSYPGEQ---MILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEF 293
++ G Q M+ +C F C+ NF S+ Y YG CY FN +LPS G
Sbjct: 292 ILNRTGHQLADMLKSCNFSGHHCSASNF-SVVYTRYGKCYTFN-ADPRSSLPSRAGGMGS 349
Query: 294 GLKLILDIGQEDYVPFLAST------AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVL 347
GL+++LDI QE+Y+P T AG+R+ +H Q P+I G G +T +
Sbjct: 350 GLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQ 409
Query: 348 VDKLQRMGEPYSPCTVNGS--EVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYL 405
+L + +P+ C E +Q + + YS+ AC C ++ +++ C+C +
Sbjct: 410 EQRLTYLPQPWGNCRAESELREPELQGY-----SAYSVSACRLRCEKEAVLQRCHCR--M 462
Query: 406 YPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSE 465
+P E C + + A D + C C CN T+Y ISM P+
Sbjct: 463 VHMPGNETICPPNIYIECADHTLD-SLGGGPEGPCF--CPTPCNLTRYGKEISMVRIPNR 519
Query: 466 ASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQ 525
S ++ R + N T R+ + L+++F+ +E+ AA + LL +LGGQ
Sbjct: 520 GSARYL------ARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQ 573
Query: 526 FGFWMGGSVLCLIEFGEIIIDFVW 549
G ++G S+L L+E + I + W
Sbjct: 574 MGLFIGASILTLLEILDYIYEVSW 597
Score = 35.8 bits (81), Expect = 0.12
Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 5/95 (5%)
Query: 18 PGYTYKELLVWYCDNTNTHGPKRIICEGPK--KKAMWFLLTLLFAALVCWQWGIFIRTYL 75
PG ++L + + HG R GP ++ +W L L A +Q R YL
Sbjct: 162 PGAAPRDLAT-FASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYL 220
Query: 76 SWE--VSVSLSVGFKTMDFPAVTICNASPFKYSKI 108
+ V++ + FPAVT+CN + F++S +
Sbjct: 221 TRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSAL 255
>gi|31442761 amiloride-sensitive cation channel 5, intestinal [Homo
sapiens]
Length = 505
Score = 129 bits (325), Expect = 6e-30
Identities = 89/330 (26%), Positives = 153/330 (46%), Gaps = 30/330 (9%)
Query: 240 YPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLIL 299
Y +L C F +PC+ ++F +F YGNC+ FN G T +A + GL L+
Sbjct: 176 YLNNSTLLDCEFFGKPCSPKDFAHVF-TEYGNCFTFNHGETLQAKRKVSVSGR-GLSLLF 233
Query: 300 DIGQEDYV--PFLAST-AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGE 356
++ QE + P L AG+ ++H + P G+ + G + + K
Sbjct: 234 NVNQEAFTDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEY 293
Query: 357 PYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCN 416
P+ C N + +QNF S YS CL+ C H+ + C C +L P Y
Sbjct: 294 PWGECNPN---IKLQNFSS-----YSTSGCLKECKAQHIKKQCGCVPFLLP-----GYGI 340
Query: 417 NRDFPDWAHCYSDLQMSVAQRETCI-----GMCKESCNDTQYKMTISMADWPSEASEDWI 471
D + C S + + ++ C C SC + +Y TIS + +PS+ + ++
Sbjct: 341 ECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYL 400
Query: 472 FHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMG 531
L+Q R R+ +VK+ I + + NY+ ++ A ++ LL++LGGQ G + G
Sbjct: 401 SKKLNQSRKYI------RENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCG 454
Query: 532 GSVLCLIEFGE-IIIDFVWITIIKLVALAK 560
S++ +IE E + +F WI I L+ +++
Sbjct: 455 ASLITIIEIIEYLFTNFYWICIFFLLKISE 484
Score = 49.3 bits (116), Expect = 1e-05
Identities = 25/75 (33%), Positives = 43/75 (57%), Gaps = 2/75 (2%)
Query: 32 NTNTHGPKRIICEGPK-KKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGF-KT 89
+T+ HG I+ K ++ +W ++ L +LV WQ I + Y +W + S+ V + +
Sbjct: 44 STSFHGIHNIVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEK 103
Query: 90 MDFPAVTICNASPFK 104
M+FPAVT CN + F+
Sbjct: 104 MEFPAVTFCNLNRFQ 118
>gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo
sapiens]
Length = 647
Score = 126 bits (317), Expect = 5e-29
Identities = 102/384 (26%), Positives = 169/384 (44%), Gaps = 72/384 (18%)
Query: 192 AMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFA--------------QVPQQELVE 237
A+ LC++NR FR+ AL++ I N+ + P+ ++V+
Sbjct: 241 AVTLCNINR----FRH-----SALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVD 291
Query: 238 -MSYPGEQ---MILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKALPSANPGTEF 293
++ G Q M+ +C F C+ NF S+ Y YG CY FN +LPS G
Sbjct: 292 ILNRTGHQLADMLKSCNFSGHHCSASNF-SVVYTRYGKCYTFN-ADPRSSLPSRAGGMGS 349
Query: 294 GLKLILDIGQEDYVPFLAST------AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVL 347
GL+++LDI QE+Y+P T AG+R+ +H Q P+I G G +T +
Sbjct: 350 GLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQ 409
Query: 348 VDKLQRMGEPYSPCTVNGS--EVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYL 405
+L + +P+ C E +Q + + YS+ AC C ++ +++ C+C
Sbjct: 410 EQRLTYLPQPWGNCRAESELREPELQGY-----SAYSVSACRLRCEKEAVLQRCHCRMVH 464
Query: 406 YPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSE 465
P G + P C+ C CN T+Y ISM P+
Sbjct: 465 MPDSLG----GGPEGP----CF----------------CPTPCNLTRYGKEISMVRIPNR 500
Query: 466 ASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQ 525
S ++ R + N T R+ + L+++F+ +E+ AA + LL +LGGQ
Sbjct: 501 GSARYL------ARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQ 554
Query: 526 FGFWMGGSVLCLIEFGEIIIDFVW 549
G ++G S+L L+E + I + W
Sbjct: 555 MGLFIGASILTLLEILDYIYEVSW 578
Score = 35.8 bits (81), Expect = 0.12
Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 5/95 (5%)
Query: 18 PGYTYKELLVWYCDNTNTHGPKRIICEGPK--KKAMWFLLTLLFAALVCWQWGIFIRTYL 75
PG ++L + + HG R GP ++ +W L L A +Q R YL
Sbjct: 162 PGAAPRDLAT-FASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYL 220
Query: 76 SWE--VSVSLSVGFKTMDFPAVTICNASPFKYSKI 108
+ V++ + FPAVT+CN + F++S +
Sbjct: 221 TRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSAL 255
>gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo
sapiens]
Length = 531
Score = 123 bits (308), Expect = 6e-28
Identities = 83/321 (25%), Positives = 148/321 (46%), Gaps = 33/321 (10%)
Query: 243 EQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMT-EKALPSANPGTEFGLKLILDI 301
+ M+L C F +PC NFT+IF G CY FN G + L + G GL ++LD+
Sbjct: 158 DDMLLDCRFRGQPCGPENFTTIF-TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDV 216
Query: 302 GQEDYVPFLAST------AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMG 355
QE+Y+P G+R+ +H Q P I G+ G +T + +L +
Sbjct: 217 QQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLP 276
Query: 356 EPYSPCTVNGSEVPVQNFYSDY--------NTTYSIQACLRSCFQDHMIRNCNCGHYLYP 407
P+ C+ + SD + Y++ C +C ++ R C C +
Sbjct: 277 PPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCR--MVY 334
Query: 408 LPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEAS 467
+P C+ + + + AH D + ++++C C C T+Y +SM PS A+
Sbjct: 335 MPGDVPVCSPQQYKNCAHPAIDAML---RKDSCA--CPNPCASTRYAKELSMVRIPSRAA 389
Query: 468 EDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFG 527
++ L++ + ++ L+I+F+ NY T+E+ A + LL ++GGQ G
Sbjct: 390 ARFLARKLNRSE------AYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMG 443
Query: 528 FWMGGSVLCLIEFGEIIIDFV 548
++G S+L ++E I+D++
Sbjct: 444 LFIGASLLTILE----ILDYL 460
Score = 33.5 bits (75), Expect = 0.62
Identities = 21/83 (25%), Positives = 37/83 (44%), Gaps = 3/83 (3%)
Query: 29 YCDNTNTHGPKRIICEGPK--KKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVG 86
+ N + HG + G ++ MW +L A +Q +R Y + +L
Sbjct: 20 FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDER 79
Query: 87 FK-TMDFPAVTICNASPFKYSKI 108
+ FPAVT+CN +P + S++
Sbjct: 80 ESHRLIFPAVTLCNINPLRRSRL 102
>gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo
sapiens]
Length = 549
Score = 123 bits (308), Expect = 6e-28
Identities = 83/321 (25%), Positives = 148/321 (46%), Gaps = 33/321 (10%)
Query: 243 EQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMT-EKALPSANPGTEFGLKLILDI 301
+ M+L C F +PC NFT+IF G CY FN G + L + G GL ++LD+
Sbjct: 158 DDMLLDCRFRGQPCGPENFTTIF-TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDV 216
Query: 302 GQEDYVPFLAST------AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMG 355
QE+Y+P G+R+ +H Q P I G+ G +T + +L +
Sbjct: 217 QQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLP 276
Query: 356 EPYSPCTVNGSEVPVQNFYSDY--------NTTYSIQACLRSCFQDHMIRNCNCGHYLYP 407
P+ C+ + SD + Y++ C +C ++ R C C +
Sbjct: 277 PPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCR--MVY 334
Query: 408 LPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEAS 467
+P C+ + + + AH D + ++++C C C T+Y +SM PS A+
Sbjct: 335 MPGDVPVCSPQQYKNCAHPAIDAML---RKDSCA--CPNPCASTRYAKELSMVRIPSRAA 389
Query: 468 EDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFG 527
++ L++ + ++ L+I+F+ NY T+E+ A + LL ++GGQ G
Sbjct: 390 ARFLARKLNRSE------AYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMG 443
Query: 528 FWMGGSVLCLIEFGEIIIDFV 548
++G S+L ++E I+D++
Sbjct: 444 LFIGASLLTILE----ILDYL 460
Score = 33.5 bits (75), Expect = 0.62
Identities = 21/83 (25%), Positives = 37/83 (44%), Gaps = 3/83 (3%)
Query: 29 YCDNTNTHGPKRIICEGPK--KKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVG 86
+ N + HG + G ++ MW +L A +Q +R Y + +L
Sbjct: 20 FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDER 79
Query: 87 FK-TMDFPAVTICNASPFKYSKI 108
+ FPAVT+CN +P + S++
Sbjct: 80 ESHRLIFPAVTLCNINPLRRSRL 102
>gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo
sapiens]
Length = 543
Score = 123 bits (308), Expect = 6e-28
Identities = 83/321 (25%), Positives = 148/321 (46%), Gaps = 33/321 (10%)
Query: 243 EQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMT-EKALPSANPGTEFGLKLILDI 301
+ M+L C F +PC NFT+IF G CY FN G + L + G GL ++LD+
Sbjct: 158 DDMLLDCRFRGQPCGPENFTTIF-TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDV 216
Query: 302 GQEDYVPFLAST------AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMG 355
QE+Y+P G+R+ +H Q P I G+ G +T + +L +
Sbjct: 217 QQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLP 276
Query: 356 EPYSPCTVNGSEVPVQNFYSDY--------NTTYSIQACLRSCFQDHMIRNCNCGHYLYP 407
P+ C+ + SD + Y++ C +C ++ R C C +
Sbjct: 277 PPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCR--MVY 334
Query: 408 LPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEAS 467
+P C+ + + + AH D + ++++C C C T+Y +SM PS A+
Sbjct: 335 MPGDVPVCSPQQYKNCAHPAIDAML---RKDSCA--CPNPCASTRYAKELSMVRIPSRAA 389
Query: 468 EDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFG 527
++ L++ + ++ L+I+F+ NY T+E+ A + LL ++GGQ G
Sbjct: 390 ARFLARKLNRSE------AYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMG 443
Query: 528 FWMGGSVLCLIEFGEIIIDFV 548
++G S+L ++E I+D++
Sbjct: 444 LFIGASLLTILE----ILDYL 460
Score = 33.5 bits (75), Expect = 0.62
Identities = 21/83 (25%), Positives = 37/83 (44%), Gaps = 3/83 (3%)
Query: 29 YCDNTNTHGPKRIICEGPK--KKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVG 86
+ N + HG + G ++ MW +L A +Q +R Y + +L
Sbjct: 20 FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDER 79
Query: 87 FK-TMDFPAVTICNASPFKYSKI 108
+ FPAVT+CN +P + S++
Sbjct: 80 ESHRLIFPAVTLCNINPLRRSRL 102
>gi|21536351 amiloride-sensitive cation channel 2, neuronal isoform
a [Homo sapiens]
Length = 574
Score = 121 bits (304), Expect = 2e-27
Identities = 84/285 (29%), Positives = 133/285 (46%), Gaps = 24/285 (8%)
Query: 245 MILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMTEKA-LPSANPGTEFGLKLILDIGQ 303
M+L+C F E C+ +F +F YG CY FN G + L + GT GL+++LDI Q
Sbjct: 168 MLLSCHFRGEVCSAEDFKVVF-TRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQ 226
Query: 304 EDYVPFLAST------AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEP 357
++Y+P T AG+++ +H Q PFI G G +T + +L + P
Sbjct: 227 DEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPP 286
Query: 358 YSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNN 417
+ C + + D+ +YSI AC C +++ NCNC + +P YC
Sbjct: 287 WGTCKAVTMDSDL-----DFFDSYSITACRIDCETRYLVENCNC--RMVHMPGDAPYCTP 339
Query: 418 RDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQ 477
+ + A D + Q E C+ C+ CN T+Y +SM PS+AS ++ ++
Sbjct: 340 EQYKECADPALDFLVEKDQ-EYCV--CEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK 396
Query: 478 ERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNL 522
+ I+ L+I+F+ NY TIE+ A I LL L
Sbjct: 397 SEQ------YIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGEL 435
Score = 35.0 bits (79), Expect = 0.21
Identities = 27/93 (29%), Positives = 46/93 (49%), Gaps = 8/93 (8%)
Query: 48 KKAMW---FLLTLLFAALVCWQWGIFIRTYLSWEVSVSLS-VGFKTMDFPAVTICNASPF 103
K+A+W FL +L VC + ++ Y + L V + FPAVT+CN + F
Sbjct: 42 KRALWALCFLGSLAVLLCVCTER---VQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEF 98
Query: 104 KYSKI-KHLLKDLDELMEAVLERILAPELSHAN 135
++S++ K+ L EL+ + R P+ A+
Sbjct: 99 RFSQVSKNDLYHAGELLALLNNRYEIPDTQMAD 131
>gi|239757391 PREDICTED: hypothetical protein XP_002345269 [Homo
sapiens]
Length = 454
Score = 35.8 bits (81), Expect = 0.12
Identities = 24/64 (37%), Positives = 31/64 (48%), Gaps = 12/64 (18%)
Query: 563 RQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDS 622
RQRR+ P P V + ++A P+T RSP P P A+P+PGTP N
Sbjct: 334 RQRRS----GSPVPPVLQCLQA-------PETC-RSPTGAPPPHRTAVPVPGTPHKNAPL 381
Query: 623 LRLQ 626
L Q
Sbjct: 382 LETQ 385
>gi|239751897 PREDICTED: hypothetical protein XP_002348038 [Homo
sapiens]
Length = 454
Score = 35.8 bits (81), Expect = 0.12
Identities = 24/64 (37%), Positives = 31/64 (48%), Gaps = 12/64 (18%)
Query: 563 RQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDS 622
RQRR+ P P V + ++A P+T RSP P P A+P+PGTP N
Sbjct: 334 RQRRS----GSPVPPVLQCLQA-------PETC-RSPTGAPPPHRTAVPVPGTPHKNAPL 381
Query: 623 LRLQ 626
L Q
Sbjct: 382 LETQ 385
>gi|239746387 PREDICTED: hypothetical protein XP_002343741 [Homo
sapiens]
Length = 454
Score = 35.8 bits (81), Expect = 0.12
Identities = 24/64 (37%), Positives = 31/64 (48%), Gaps = 12/64 (18%)
Query: 563 RQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDS 622
RQRR+ P P V + ++A P+T RSP P P A+P+PGTP N
Sbjct: 334 RQRRS----GSPVPPVLQCLQA-------PETC-RSPTGAPPPHRTAVPVPGTPHKNAPL 381
Query: 623 LRLQ 626
L Q
Sbjct: 382 LETQ 385
>gi|118402590 myosin XV [Homo sapiens]
Length = 3530
Score = 32.7 bits (73), Expect = 1.1
Identities = 22/68 (32%), Positives = 30/68 (44%), Gaps = 3/68 (4%)
Query: 563 RQRRAQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPNTGPYPSEQALP-IPGTPPP--N 619
R R + + P P A +H + P PR P++GP P+ P + G P P
Sbjct: 634 RARSSNDARRPPAPQPAPRTLSHWSALLSPPVPPRPPSSGPPPAPPLSPALSGLPRPASP 693
Query: 620 YDSLRLQP 627
Y SLR P
Sbjct: 694 YGSLRRHP 701
>gi|102468717 mediator complex subunit 13 [Homo sapiens]
Length = 2174
Score = 31.6 bits (70), Expect = 2.3
Identities = 17/38 (44%), Positives = 21/38 (55%), Gaps = 5/38 (13%)
Query: 583 EAHTNFGFQPDTAPRSPNTG----PYPSEQALPIPGTP 616
+ HT+FG P +AP S N+G P PS P P TP
Sbjct: 979 QTHTSFGMPPSSAPPS-NSGAGILPSPSTPRFPTPRTP 1015
>gi|148922900 general transcription factor IIH, polypeptide 2B [Homo
sapiens]
Length = 395
Score = 31.2 bits (69), Expect = 3.1
Identities = 31/157 (19%), Positives = 55/157 (35%), Gaps = 15/157 (9%)
Query: 95 VTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLID 154
V +C + H++ D E + + P S ++ + HT L D
Sbjct: 205 VRVCTVLARETGGTYHVILDESHYKELLTHHVSPPPASSSSECSLIRMGFPQHTIASLSD 264
Query: 155 ERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAM--RLCSLNRTQCTFRNFTSAT 212
+ + L G+ GLT C A C++ + ++C L SA
Sbjct: 265 QDAKPSFSMAHLDGNTEPGLTLGGYFCPQCRAKYCELPVECKICGL--------TLVSAP 316
Query: 213 QALTEWYILQATNIFAQVPQQELVEMSYPGEQMILAC 249
++ L + F ++P +E Y GE+ C
Sbjct: 317 HLARSYHHLFPLDAFQEIPLEE-----YNGERFCYGC 348
>gi|6681762 general transcription factor IIH, polypeptide 2, 44kD
subunit [Homo sapiens]
Length = 395
Score = 31.2 bits (69), Expect = 3.1
Identities = 31/157 (19%), Positives = 55/157 (35%), Gaps = 15/157 (9%)
Query: 95 VTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLID 154
V +C + H++ D E + + P S ++ + HT L D
Sbjct: 205 VRVCTVLARETGGTYHVILDESHYKELLTHHVSPPPASSSSECSLIRMGFPQHTIASLSD 264
Query: 155 ERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAM--RLCSLNRTQCTFRNFTSAT 212
+ + L G+ GLT C A C++ + ++C L SA
Sbjct: 265 QDAKPSFSMAHLDGNTEPGLTLGGYFCPQCRAKYCELPVECKICGL--------TLVSAP 316
Query: 213 QALTEWYILQATNIFAQVPQQELVEMSYPGEQMILAC 249
++ L + F ++P +E Y GE+ C
Sbjct: 317 HLARSYHHLFPLDAFQEIPLEE-----YNGERFCYGC 348
>gi|148922852 general transcription factor IIH, polypeptide 2C [Homo
sapiens]
Length = 395
Score = 30.8 bits (68), Expect = 4.0
Identities = 31/157 (19%), Positives = 55/157 (35%), Gaps = 15/157 (9%)
Query: 95 VTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLID 154
V +C + H++ D E + + P S ++ + HT L D
Sbjct: 205 VRVCTVLARETGGTYHVILDESHYKELLTHHLSPPPASSSSECSLIRMGFPQHTIASLSD 264
Query: 155 ERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAM--RLCSLNRTQCTFRNFTSAT 212
+ + L G+ GLT C A C++ + ++C L SA
Sbjct: 265 QDAKPSFSMAHLDGNTEPGLTLGGYFCPQCRAKYCELPVECKICGL--------TLVSAP 316
Query: 213 QALTEWYILQATNIFAQVPQQELVEMSYPGEQMILAC 249
++ L + F ++P +E Y GE+ C
Sbjct: 317 HLARSYHHLFPLDAFQEIPLEE-----YNGERFCYGC 348
>gi|109809737 general transcription factor IIH, polypeptide 2D [Homo
sapiens]
Length = 395
Score = 30.8 bits (68), Expect = 4.0
Identities = 31/157 (19%), Positives = 55/157 (35%), Gaps = 15/157 (9%)
Query: 95 VTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLID 154
V +C + H++ D E + + P S ++ + HT L D
Sbjct: 205 VRVCTVLARETGGTYHVILDESHYKELLTHHLSPPPASSSSECSLIRMGFPQHTIASLSD 264
Query: 155 ERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAM--RLCSLNRTQCTFRNFTSAT 212
+ + L G+ GLT C A C++ + ++C L SA
Sbjct: 265 QDAKPSFSMAHLDGNTEPGLTLGGYFCPQCRAKYCELPVECKICGL--------TLVSAP 316
Query: 213 QALTEWYILQATNIFAQVPQQELVEMSYPGEQMILAC 249
++ L + F ++P +E Y GE+ C
Sbjct: 317 HLARSYHHLFPLDAFQEIPLEE-----YNGERFCYGC 348
>gi|237649117 renalase isoform 1 [Homo sapiens]
Length = 342
Score = 30.4 bits (67), Expect = 5.2
Identities = 29/99 (29%), Positives = 43/99 (43%), Gaps = 12/99 (12%)
Query: 93 PAVTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVL 152
P++ I PF + ++H ++D+ EL+ LE IL P L AT+ W H+ +
Sbjct: 240 PSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENIL-PGLPQPIATK---CQKWRHSQVTN 295
Query: 153 IDERNP-----HHPMVLDLFGDNHNGLTSSSASEKICNA 186
P HH L GD G T S+ I +A
Sbjct: 296 AAANCPGQMTLHHKPFLACGGD---GFTQSNFDGCITSA 331
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 30.4 bits (67), Expect = 5.2
Identities = 19/52 (36%), Positives = 21/52 (40%), Gaps = 13/52 (25%)
Query: 567 AQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPNTGPYPSEQALPIPGTPPP 618
AQAS A PPP P P P+TGP P P+P PP
Sbjct: 324 AQASVALPPPP-------------GPPPPPPLPSTGPPPPPPPPPLPNQVPP 362
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 30.4 bits (67), Expect = 5.2
Identities = 19/52 (36%), Positives = 21/52 (40%), Gaps = 13/52 (25%)
Query: 567 AQASYAGPPPTVAELVEAHTNFGFQPDTAPRSPNTGPYPSEQALPIPGTPPP 618
AQAS A PPP P P P+TGP P P+P PP
Sbjct: 324 AQASVALPPPP-------------GPPPPPPLPSTGPPPPPPPPPLPNQVPP 362
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 30.4 bits (67), Expect = 5.2
Identities = 18/57 (31%), Positives = 26/57 (45%), Gaps = 5/57 (8%)
Query: 572 AGPPPTVAELVEAHTNFGFQPDTAPRSPNTGPYPSEQALPIPGTPPPNYDSLRLQPL 628
A PP ++ L E FG + D+ P SP P L P +PPP + +P+
Sbjct: 945 AAAPPALSPLGELEYPFGAKGDSDPESPLAAP-----ILETPISPPPEANCTDPEPV 996
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,378,207
Number of Sequences: 37866
Number of extensions: 1243621
Number of successful extensions: 4100
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 3963
Number of HSP's gapped (non-prelim): 69
length of query: 640
length of database: 18,247,518
effective HSP length: 109
effective length of query: 531
effective length of database: 14,120,124
effective search space: 7497785844
effective search space used: 7497785844
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.