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Search of human proteins with 38348348
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
(446 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 921 0.0
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 399 e-111
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 398 e-111
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 147 2e-35
gi|68299759 ecotropic viral integration site 5 [Homo sapiens] 142 5e-34
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 142 8e-34
gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 141 1e-33
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 141 1e-33
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 136 3e-32
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 135 6e-32
gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso... 132 6e-31
gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso... 132 6e-31
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 126 3e-29
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 126 3e-29
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 125 1e-28
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 125 1e-28
gi|156231067 TBC1 domain family, member 8 [Homo sapiens] 124 2e-28
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 122 7e-28
gi|29648315 small G protein signaling modulator 3 [Homo sapiens] 122 7e-28
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso... 121 1e-27
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 112 5e-25
gi|90577185 TBC1 domain family member 3C [Homo sapiens] 105 8e-23
gi|226693407 TBC1 domain family, member 3H [Homo sapiens] 105 1e-22
gi|157502205 TBC1 domain family, member 3G [Homo sapiens] 105 1e-22
gi|14149985 TBC1 domain family, member 3F [Homo sapiens] 104 1e-22
gi|183583565 TBC1 domain family, member 3 [Homo sapiens] 104 2e-22
gi|183583567 TBC1 domain family, member 3E [Homo sapiens] 104 2e-22
gi|183583563 TBC1 domain family, member 3D [Homo sapiens] 104 2e-22
gi|149999613 TBC1 domain family, member 3B [Homo sapiens] 103 2e-22
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 102 5e-22
>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
Length = 446
Score = 921 bits (2381), Expect = 0.0
Identities = 446/446 (100%), Positives = 446/446 (100%)
Query: 1 MAQALGEDLVQPPELQDDSSSLGSDSELSGPGPYRQADRYGFIGGSSAEPGPGHPPADLI 60
MAQALGEDLVQPPELQDDSSSLGSDSELSGPGPYRQADRYGFIGGSSAEPGPGHPPADLI
Sbjct: 1 MAQALGEDLVQPPELQDDSSSLGSDSELSGPGPYRQADRYGFIGGSSAEPGPGHPPADLI 60
Query: 61 RQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQ 120
RQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQ
Sbjct: 61 RQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQ 120
Query: 121 ELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQ 180
ELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQ
Sbjct: 121 ELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQ 180
Query: 181 GPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKH 240
GPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKH
Sbjct: 181 GPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKH 240
Query: 241 LQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAE 300
LQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAE
Sbjct: 241 LQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAE 300
Query: 301 QRGACPGLLETLGALRAIPPAQLQEEAFMSQVHSVVLSERDLQREIKAQLAQLPDSAPGP 360
QRGACPGLLETLGALRAIPPAQLQEEAFMSQVHSVVLSERDLQREIKAQLAQLPDSAPGP
Sbjct: 301 QRGACPGLLETLGALRAIPPAQLQEEAFMSQVHSVVLSERDLQREIKAQLAQLPDSAPGP 360
Query: 361 PPRPQVRLAGAQAIFEAQQLAGVRRGAKPEVPRIVVQPPEEPRPPRRKPQTRGKTFHGLL 420
PPRPQVRLAGAQAIFEAQQLAGVRRGAKPEVPRIVVQPPEEPRPPRRKPQTRGKTFHGLL
Sbjct: 361 PPRPQVRLAGAQAIFEAQQLAGVRRGAKPEVPRIVVQPPEEPRPPRRKPQTRGKTFHGLL 420
Query: 421 TRARGPPIEGPPRPQRGSTSFLDTRF 446
TRARGPPIEGPPRPQRGSTSFLDTRF
Sbjct: 421 TRARGPPIEGPPRPQRGSTSFLDTRF 446
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 399 bits (1026), Expect = e-111
Identities = 205/439 (46%), Positives = 292/439 (66%), Gaps = 18/439 (4%)
Query: 7 EDLVQPPELQ--DDSSSLGSDSELSGPGPYRQADRYGFIGGSS-AEPGPGHPPADLIRQR 63
E L Q P+ D+ SSLGSDSE +G R+ D++GFI GS AE P +++RQR
Sbjct: 24 ESLAQGPDAATTDELSSLGSDSEANGFAE-RRIDKFGFIVGSQGAEGALEEVPLEVLRQR 82
Query: 64 EMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELA 123
E KW++M ++W+K M++++KK++++C+KGIP +LR R W L G V + +PG + EL
Sbjct: 83 ESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELD 142
Query: 124 EAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPV 183
+PGDP+W++ I RDLHRQFP HEMFVS GHGQQ L +VLKAYTLYRPE+GYCQAQ P+
Sbjct: 143 MSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPI 202
Query: 184 AAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQ 243
AAVLLMH+P E+AFWCLVQICE YLPGYY +EA++LD E+ +LL+++ P HKHL +
Sbjct: 203 AAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSR 262
Query: 244 VGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQRG 303
+ PLLY+ EWF+C F+R+LP+ +VLRVWD F EG +++FRVGL L++ ALG+ E+
Sbjct: 263 QKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKVK 322
Query: 304 ACPGLLETLGALRAIPPAQLQEEAFMSQVHSVVLSERDLQREIKAQLAQLPDSAPGPPPR 363
AC G ET+ LR++ P +QE + +V + ++ER ++RE QL + ++ R
Sbjct: 323 ACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTERQIEREHLIQLRRWQETRGELQCR 382
Query: 364 PQVRLAGAQAIFEAQQLAGVRRGAKPEVP-RIVVQPP-----EEPRPPRRKPQTRGKTFH 417
RL GA+AI +A+ G R +P R+ + P +P+PP++ + + K
Sbjct: 383 SPPRLHGAKAILDAE--PGPRPALQPSPSIRLPLDAPLPGSKAKPKPPKQAQKEQRKQMK 440
Query: 418 GLLTRARGPPIEGPPRPQR 436
G RG +E PP P +
Sbjct: 441 G-----RG-QLEKPPAPNQ 453
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 398 bits (1023), Expect = e-111
Identities = 186/366 (50%), Positives = 265/366 (72%), Gaps = 2/366 (0%)
Query: 15 LQDDSSSLGSDSELSGPGPYRQADRYGFIGGSSAEPG-PGHPPADLIRQREMKWVEMTSH 73
L DD SS+GSDSE++G R+ D+YGF+GGS P D+ RQRE+KW++M S+
Sbjct: 283 LADDVSSMGSDSEINGLA-LRKTDKYGFLGGSQYSGSLESSIPVDVARQRELKWLDMFSN 341
Query: 74 WEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWME 133
W+K +SRR++KVK++CRKGIPS+LRA+ W L + + +PG ++EL APGDP+W++
Sbjct: 342 WDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLD 401
Query: 134 TIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPP 193
I +DLHRQFP HEMF + GHGQQ L ++LKAYT+YRP++GYCQAQ PVAAVLLMH+P
Sbjct: 402 VIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPA 461
Query: 194 EEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLP 253
E+AFWCLVQIC+ YLPGYY +EA++LD E+F ALLRR P H+HL++ + P+LY+
Sbjct: 462 EQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMT 521
Query: 254 EWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQRGACPGLLETLG 313
EWF+C+FAR+LP+ +VLRVWD F EG +++FRV L L+R LG+ E+ +C G+ ET+
Sbjct: 522 EWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETME 581
Query: 314 ALRAIPPAQLQEEAFMSQVHSVVLSERDLQREIKAQLAQLPDSAPGPPPRPQVRLAGAQA 373
LR +P +QE+ + +V ++ ++E ++RE AQL + ++ RP RL G++A
Sbjct: 582 QLRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRETRGELQYRPSRRLHGSRA 641
Query: 374 IFEAQQ 379
I E ++
Sbjct: 642 IHEERR 647
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 147 bits (371), Expect = 2e-35
Identities = 93/290 (32%), Positives = 133/290 (45%), Gaps = 5/290 (1%)
Query: 6 GEDLVQPPELQDDSSSLGSDSELSGPGPYR-QADRYGFIGGSSAEPGPGHPPADLIRQRE 64
G+ + + LQ +S + SG GP Q D + G G D +
Sbjct: 451 GDAIYEVVSLQRESDKEEPVTPTSGGGPMSPQDDEAEEESDNELSSGTGDVSKDCPEKIL 510
Query: 65 MKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAE 124
W E+ W + R K + + G+P ALRA W LL G H Q Y+ L
Sbjct: 511 YSWGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLD-RYRILIT 569
Query: 125 APGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVA 184
D I RD+HR FP H+ F G GQ+ L ++ KAY++Y + GYCQ Q +A
Sbjct: 570 K--DSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLA 627
Query: 185 AVLLMHLPPEEAFWCLVQICEVY-LPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQ 243
AVLL+H+P E+AF LV+I Y L Y + E + L++ LP +H H
Sbjct: 628 AVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSD 687
Query: 244 VGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVR 293
+ + +Y +WFL LF P V + D L EG ++F V L L++
Sbjct: 688 LNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLK 737
>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
Length = 810
Score = 142 bits (359), Expect = 5e-34
Identities = 92/295 (31%), Positives = 139/295 (47%), Gaps = 10/295 (3%)
Query: 2 AQALGEDLVQPPELQDDSSSLGSDSE-LSGPGPYRQADRYGFIGGSSAEPGPGHPPADLI 60
+Q +DL +L++ + L +DS+ L R+ + SSA H D
Sbjct: 76 SQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSASSNLSHLEED-- 133
Query: 61 RQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQ 120
+ W + + WE ++ K+VK KGIP RA W LLC A Y
Sbjct: 134 --SWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQ--YS 189
Query: 121 ELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQ 180
EL + + + I RD+ R +P H F GQ+ L V+KAY+L E GYCQ
Sbjct: 190 ELLKMTSPCE--KLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGS 247
Query: 181 GPVAAVLLMHLPPEEAFWCLVQICEVY-LPGYYGPHMEAVRLDAEVFMALLRRLLPHVHK 239
+ +LLM +P EEAF V++ + Y L + P M + L F +++ LP +
Sbjct: 248 AFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFV 307
Query: 240 HLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRL 294
H Q +Y WFL +F + P P R++D F+SEG ++FRVGL L+++
Sbjct: 308 HFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQM 362
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 142 bits (357), Expect = 8e-34
Identities = 85/236 (36%), Positives = 123/236 (52%), Gaps = 5/236 (2%)
Query: 60 IRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTY 119
+ +R +KW + SR VK RKG+P RAR W +L GA +PG Y
Sbjct: 39 LTRRAIKWSRLLQGGGVPRSRT---VKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYY 95
Query: 120 QELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHG-QQGLLQVLKAYTLYRPEQGYCQ 178
+L + +P+ + I DL+R FP + F Q+ L VL AY + GYCQ
Sbjct: 96 HQLLQGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQ 155
Query: 179 AQGPVAAVLLMHLP-PEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHV 237
+A L++ EE+FW L + LP YY P M ++ D EV L+R LP V
Sbjct: 156 GMNFIAGYLILITNNEEESFWLLDALVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAV 215
Query: 238 HKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVR 293
++++GV L + WF+CLF LP TVLR+WD +EG++++FRV LTL++
Sbjct: 216 GALMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIK 271
>gi|229577000 ecotropic viral integration site 5-like isoform 1
[Homo sapiens]
Length = 805
Score = 141 bits (356), Expect = 1e-33
Identities = 93/284 (32%), Positives = 139/284 (48%), Gaps = 12/284 (4%)
Query: 14 ELQDDSSSLGSDSE-LSGPGPYRQADRYGFIGGSSAEPGPGHPPADLIRQREMKWVEMTS 72
+L++ + L +DS+ + R+ + SSA H D + W + +
Sbjct: 40 KLEEQNRLLEADSKSMRSMNGSRRNSGSSLVSSSSASSNLSHLEEDTW----ILWGRIAN 95
Query: 73 HWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGA-HVCQKNSPGTYQELAEAPGDPQW 131
WE+ R+ K +K RKGIP RA W LLC A + KN Y EL + +
Sbjct: 96 EWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ---YSELLKMSSPCE- 151
Query: 132 METIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHL 191
+ I RD+ R +P HE F GQ+ L V+KAY+L E GYCQ + +LLM +
Sbjct: 152 -KLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQM 210
Query: 192 PPEEAFWCLVQICEVY-LPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLL 250
P EEAF V++ + Y L + P M + L F +L+ LP ++ H + +
Sbjct: 211 PEEEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSM 270
Query: 251 YLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRL 294
Y WFL LF + P P RV+D F+ EG ++FRVGL L+++
Sbjct: 271 YASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQV 314
>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
sapiens]
Length = 794
Score = 141 bits (356), Expect = 1e-33
Identities = 93/284 (32%), Positives = 139/284 (48%), Gaps = 12/284 (4%)
Query: 14 ELQDDSSSLGSDSE-LSGPGPYRQADRYGFIGGSSAEPGPGHPPADLIRQREMKWVEMTS 72
+L++ + L +DS+ + R+ + SSA H D + W + +
Sbjct: 40 KLEEQNRLLEADSKSMRSMNGSRRNSGSSLVSSSSASSNLSHLEEDTW----ILWGRIAN 95
Query: 73 HWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGA-HVCQKNSPGTYQELAEAPGDPQW 131
WE+ R+ K +K RKGIP RA W LLC A + KN Y EL + +
Sbjct: 96 EWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ---YSELLKMSSPCE- 151
Query: 132 METIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHL 191
+ I RD+ R +P HE F GQ+ L V+KAY+L E GYCQ + +LLM +
Sbjct: 152 -KLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQM 210
Query: 192 PPEEAFWCLVQICEVY-LPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLL 250
P EEAF V++ + Y L + P M + L F +L+ LP ++ H + +
Sbjct: 211 PEEEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSM 270
Query: 251 YLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRL 294
Y WFL LF + P P RV+D F+ EG ++FRVGL L+++
Sbjct: 271 YASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQV 314
>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
sapiens]
Length = 1266
Score = 136 bits (343), Expect = 3e-32
Identities = 83/233 (35%), Positives = 118/233 (50%), Gaps = 6/233 (2%)
Query: 63 REMKW-VEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQE 121
+E W + + + R +K + KGIP ++R W LL GA + PG Y++
Sbjct: 485 KEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYED 544
Query: 122 LAEAPGDPQWMET--IGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQA 179
L E + T I RDLHR P H F + G L +VL AY P GYCQA
Sbjct: 545 LVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIA--ALRRVLTAYAFRNPNIGYCQA 602
Query: 180 QGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHK 239
V +VLL++ EEAFW LV +CE LP YY + +D VF L R +P ++
Sbjct: 603 MNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQGVFEELARDYVPQLYD 662
Query: 240 HLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLV 292
+Q +GV + L WFL LF +PF + + V D F EG +V+F++ L ++
Sbjct: 663 CMQDLGVISTISL-SWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVL 714
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 135 bits (341), Expect = 6e-32
Identities = 80/230 (34%), Positives = 117/230 (50%), Gaps = 8/230 (3%)
Query: 67 WVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELA--E 124
W E+ S W ++ R K++ R G+P ALR W LL G H + Y+ L E
Sbjct: 541 WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHN-NDHLVEKYRILITKE 599
Query: 125 APGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVA 184
+P D I RD++R FP H+ F G GQ L ++ KAY++Y E GYCQ Q +A
Sbjct: 600 SPQD----SAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLA 655
Query: 185 AVLLMHLPPEEAFWCLVQICEVY-LPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQ 243
AVLL+H+P E+AF LV+I Y L + + E + L++ +P ++ H
Sbjct: 656 AVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLD 715
Query: 244 VGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVR 293
+ + +Y +WFL LF P V + D L EG V+F V L L++
Sbjct: 716 ISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLK 765
>gi|45597177 TBC1 domain family, member 9B (with GRAM domain)
isoform b [Homo sapiens]
Length = 1233
Score = 132 bits (332), Expect = 6e-31
Identities = 83/235 (35%), Positives = 113/235 (48%), Gaps = 6/235 (2%)
Query: 61 RQREMKW-VEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTY 119
+ +E W + + R K + KGIP +LR W L GA PG Y
Sbjct: 476 KMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYY 535
Query: 120 QELAEAPGDPQWMET--IGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYC 177
EL E + T I RDLHR P H F + G L +VL AY P GYC
Sbjct: 536 AELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIA--ALRRVLTAYAFRNPTIGYC 593
Query: 178 QAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHV 237
QA V +VLL++ EEAFW LV +CE LP YY + +D +F L R LP +
Sbjct: 594 QAMNIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQL 653
Query: 238 HKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLV 292
+ +Q +GV + L WFL LF +PF + + + D F EG +V+ +V L ++
Sbjct: 654 SEKMQDLGVISSISL-SWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVL 707
>gi|45597175 TBC1 domain family, member 9B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1250
Score = 132 bits (332), Expect = 6e-31
Identities = 83/235 (35%), Positives = 113/235 (48%), Gaps = 6/235 (2%)
Query: 61 RQREMKW-VEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTY 119
+ +E W + + R K + KGIP +LR W L GA PG Y
Sbjct: 476 KMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYY 535
Query: 120 QELAEAPGDPQWMET--IGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYC 177
EL E + T I RDLHR P H F + G L +VL AY P GYC
Sbjct: 536 AELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIA--ALRRVLTAYAFRNPTIGYC 593
Query: 178 QAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHV 237
QA V +VLL++ EEAFW LV +CE LP YY + +D +F L R LP +
Sbjct: 594 QAMNIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQL 653
Query: 238 HKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLV 292
+ +Q +GV + L WFL LF +PF + + + D F EG +V+ +V L ++
Sbjct: 654 SEKMQDLGVISSISL-SWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVL 707
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 126 bits (317), Expect = 3e-29
Identities = 85/270 (31%), Positives = 128/270 (47%), Gaps = 14/270 (5%)
Query: 34 YRQADRYGFIGGSSAEPGPGHPPA-----DLIRQREMKWVEMTSHWEKTMSRRYKKVKMQ 88
Y+ DR+GF+ E P H A L +R KW++M WEK + +K +
Sbjct: 42 YKVTDRFGFL---HEEELPDHNVAVERQKHLEIERTTKWLKMLKGWEKY--KNTEKFHRR 96
Query: 89 CRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAE-APGDPQWMETIGRDLHRQFPLHE 147
KGIP LR W LL ++ + Y +L A G + I D++R F H
Sbjct: 97 IYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHI 156
Query: 148 MFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQIC--- 204
MF G QQ L VL AY++Y E GYCQ + A+LLM++ E+AFW LV++
Sbjct: 157 MFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGP 216
Query: 205 EVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSL 264
+ + G++ + E +L + L + +HL + Y +WF F
Sbjct: 217 KHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRT 276
Query: 265 PFPTVLRVWDAFLSEGARVLFRVGLTLVRL 294
PF LR+WD ++ EG RVL + T+++L
Sbjct: 277 PFTLNLRIWDIYIFEGERVLTAMSYTILKL 306
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 126 bits (317), Expect = 3e-29
Identities = 85/270 (31%), Positives = 128/270 (47%), Gaps = 14/270 (5%)
Query: 34 YRQADRYGFIGGSSAEPGPGHPPA-----DLIRQREMKWVEMTSHWEKTMSRRYKKVKMQ 88
Y+ DR+GF+ E P H A L +R KW++M WEK + +K +
Sbjct: 59 YKVTDRFGFL---HEEELPDHNVAVERQKHLEIERTTKWLKMLKGWEKY--KNTEKFHRR 113
Query: 89 CRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAE-APGDPQWMETIGRDLHRQFPLHE 147
KGIP LR W LL ++ + Y +L A G + I D++R F H
Sbjct: 114 IYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHI 173
Query: 148 MFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQIC--- 204
MF G QQ L VL AY++Y E GYCQ + A+LLM++ E+AFW LV++
Sbjct: 174 MFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGP 233
Query: 205 EVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSL 264
+ + G++ + E +L + L + +HL + Y +WF F
Sbjct: 234 KHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRT 293
Query: 265 PFPTVLRVWDAFLSEGARVLFRVGLTLVRL 294
PF LR+WD ++ EG RVL + T+++L
Sbjct: 294 PFTLNLRIWDIYIFEGERVLTAMSYTILKL 323
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 125 bits (313), Expect = 1e-28
Identities = 77/235 (32%), Positives = 119/235 (50%), Gaps = 9/235 (3%)
Query: 68 VEMTSHWEKTMSRRYK---KVKMQCRKGIPSALRARCWPLLCGAHVCQ---KNSPGTYQE 121
V+ +++ T++R ++K R GIP R++ W H + PG +Q
Sbjct: 635 VKWENYFASTVNREMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQT 694
Query: 122 LAEAPGDPQ--WMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQA 179
L + + Q + I DL R P ++ + P G Q L VL A++ P+ GYCQ
Sbjct: 695 LLQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQG 754
Query: 180 QGPVAAVLLMHLPPEEAFWCLVQICEVYLP-GYYGPHMEAVRLDAEVFMALLRRLLPHVH 238
+ AV L++L E+AFWCLV I EV++P YY + ++D VF L+ LP +H
Sbjct: 755 LNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLH 814
Query: 239 KHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVR 293
H +Q V L WFL +F S+ + ++WD+FL EG +V+FR L L +
Sbjct: 815 GHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFK 869
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 125 bits (313), Expect = 1e-28
Identities = 77/235 (32%), Positives = 119/235 (50%), Gaps = 9/235 (3%)
Query: 68 VEMTSHWEKTMSRRYK---KVKMQCRKGIPSALRARCWPLLCGAHVCQ---KNSPGTYQE 121
V+ +++ T++R ++K R GIP R++ W H + PG +Q
Sbjct: 635 VKWENYFASTVNREMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQT 694
Query: 122 LAEAPGDPQ--WMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQA 179
L + + Q + I DL R P ++ + P G Q L VL A++ P+ GYCQ
Sbjct: 695 LLQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQG 754
Query: 180 QGPVAAVLLMHLPPEEAFWCLVQICEVYLP-GYYGPHMEAVRLDAEVFMALLRRLLPHVH 238
+ AV L++L E+AFWCLV I EV++P YY + ++D VF L+ LP +H
Sbjct: 755 LNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLH 814
Query: 239 KHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVR 293
H +Q V L WFL +F S+ + ++WD+FL EG +V+FR L L +
Sbjct: 815 GHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFK 869
>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
Length = 1140
Score = 124 bits (310), Expect = 2e-28
Identities = 73/214 (34%), Positives = 109/214 (50%), Gaps = 5/214 (2%)
Query: 81 RYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWM--ETIGRD 138
R +K++ GIP +LR R W L A + PG Y L E + E I RD
Sbjct: 494 RTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEESLGKCCLVTEEIERD 553
Query: 139 LHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFW 198
LHR P H F + G L +VL AY P+ GYCQ+ + +VLL++ EEAFW
Sbjct: 554 LHRSLPEHPAFQNETGIA--ALRRVLTAYAHRNPKIGYCQSMNILTSVLLLYTKEEEAFW 611
Query: 199 CLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLC 258
LV +CE LP Y+ + ++D VF L++ LP + +H+ + + L WFL
Sbjct: 612 LLVAVCERMLPDYFNHRVIGAQVDQSVFEELIKGHLPELAEHMNDLSALASVSL-SWFLT 670
Query: 259 LFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLV 292
LF +P + + V D F +G + +F++GL ++
Sbjct: 671 LFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVL 704
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 122 bits (306), Expect = 7e-28
Identities = 104/313 (33%), Positives = 146/313 (46%), Gaps = 41/313 (13%)
Query: 1 MAQALGEDLVQPPEL---------QDDSSSLGSDS-ELSGPGPYRQADRYGFIGGSSAEP 50
+ +ALG++ + EL Q ++ SDS ELS P + D YGF+
Sbjct: 517 LQEALGDEASECSELLRQLVQEALQWEAGEASSDSIELS---PISKYDEYGFL------T 567
Query: 51 GPGHPPADLIRQREMKWVEMTSHW-------EKTMSRRYK---------KVKMQCRKGIP 94
P + DL +++ +E SH ++ + R+ ++K R G+P
Sbjct: 568 VPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLRERWAALGDLVPSAELKQLLRAGVP 627
Query: 95 SALRARCWPLLCGAHVCQKNSPGTYQEL---AEAPGDPQWMETIGRDLHRQFPLHEMFVS 151
R R W L V ++PG YQEL +A P + I DL+R FP ++ F
Sbjct: 628 REHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQ-IELDLNRTFPNNKHFTC 686
Query: 152 PQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEE-AFWCLVQICEVYLPG 210
P L +VL A++ P GYCQ +AA+ L+ L EE AFWCLV I E +P
Sbjct: 687 PTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPA 746
Query: 211 -YYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTV 269
YY + A ++D V LL LP + HL Q V L WFL +FA SL +
Sbjct: 747 DYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNIL 806
Query: 270 LRVWDAFLSEGAR 282
LRVWDAFL EG +
Sbjct: 807 LRVWDAFLYEGTK 819
>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
Length = 749
Score = 122 bits (306), Expect = 7e-28
Identities = 81/248 (32%), Positives = 125/248 (50%), Gaps = 7/248 (2%)
Query: 81 RYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWM--ETIGRD 138
R +K++ GIP +R + W L GA ++NS +Y+E+ + + + + + I +D
Sbjct: 103 RSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIEKD 162
Query: 139 LHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFW 198
L R P + F S G L +VL+A PE GYCQ G VAA LL+ L E+AFW
Sbjct: 163 LLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFW 222
Query: 199 CLVQICEVYLP-GYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFL 257
+ I E LP Y+ + V+ D V L+ + LP + K LQ+ + L WFL
Sbjct: 223 MMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFL 282
Query: 258 CLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRA 317
FA + +LR+WD F EG+RVLF++ L ++ L Q + TL +
Sbjct: 283 TAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLSDI-- 340
Query: 318 IPPAQLQE 325
P+Q+++
Sbjct: 341 --PSQMED 346
>gi|38570101 TBC1 domain family, member 8B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1120
Score = 121 bits (303), Expect = 1e-27
Identities = 78/235 (33%), Positives = 114/235 (48%), Gaps = 6/235 (2%)
Query: 61 RQREMKWVEMTSHWEKTMSR-RYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTY 119
+ +E W + + + +S R KK + +GIP LR W L GA +P Y
Sbjct: 455 KMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYY 514
Query: 120 QELAEAPGDPQWMET--IGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYC 177
E+ E + T I RDL R P H F S G L +VL AY P+ GYC
Sbjct: 515 TEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGIS--ALRRVLTAYAYRNPKIGYC 572
Query: 178 QAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHV 237
QA + +VLL++ EEAFW LV +CE LP Y+ + +D VF L+R LP +
Sbjct: 573 QAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQL 632
Query: 238 HKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLV 292
+H+ + + L WFL LF LP + + V D F +G + + ++GL ++
Sbjct: 633 TEHMTDMTFFSSVSL-SWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAIL 686
>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
[Homo sapiens]
Length = 1168
Score = 112 bits (281), Expect = 5e-25
Identities = 78/243 (32%), Positives = 112/243 (46%), Gaps = 24/243 (9%)
Query: 69 EMTSHWEKTMSRRYK-KVKMQCRK-------GIPSALRARCWPLLCGAHVCQKNSPGTYQ 120
E+T+ WEK +S + K+K K G+P R W L + P Q
Sbjct: 769 EVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQ 828
Query: 121 ELAEAPGDPQWMETIGR----------DLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLY 170
P D + E + + DL R FP H F + G GQ L +LKAY+L
Sbjct: 829 -----PKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLL 883
Query: 171 RPEQGYCQAQGPVAAVLLMHLPPEEAFWCL-VQICEVYLPGYYGPHMEAVRLDAEVFMAL 229
E GYCQ VA +LL+H+ EEAF L + ++ L Y P M +++ L
Sbjct: 884 DQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRL 943
Query: 230 LRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGL 289
L ++ HL++ +GP LY WFL +FA P V RV+D +G V+F+V L
Sbjct: 944 LHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVAL 1003
Query: 290 TLV 292
+L+
Sbjct: 1004 SLL 1006
>gi|90577185 TBC1 domain family member 3C [Homo sapiens]
Length = 549
Score = 105 bits (262), Expect = 8e-23
Identities = 82/290 (28%), Positives = 127/290 (43%), Gaps = 24/290 (8%)
Query: 27 ELSGPGPYRQ----ADRYGFIGGSSAEPGPGHPPADLIRQ--REMKWVEMTSHWEKTMSR 80
E GP P+R D G + + P + R+ R+ KWV+M WEK S
Sbjct: 32 EDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSS 91
Query: 81 RYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAE-APGDPQWMETIGRDL 139
R K+ + KG+P +R W +L + +PG YQ + E + ++ I RD+
Sbjct: 92 R--KLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDI 149
Query: 140 HRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWC 199
H F G Q+ LL +L AY Y PE GYC+ +AA+ L++LP E+AFW
Sbjct: 150 SGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWA 209
Query: 200 LVQIC---EVYLPGYYGPHMEAVR----LDAEVFMALLRRLLPHVHKHLQQVGVGPLLYL 252
LVQ+ L G++ P+ V+ V + + H K PL L
Sbjct: 210 LVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQSKTMGHQDKKDLCGQCSPLGCL 269
Query: 253 PEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQR 302
+ + + LR+WD +L EG + L + + R+A ++R
Sbjct: 270 ----IRILIDGISLGLTLRLWDVYLVEGEQAL----MPITRIAFKVQQKR 311
>gi|226693407 TBC1 domain family, member 3H [Homo sapiens]
Length = 549
Score = 105 bits (261), Expect = 1e-22
Identities = 78/286 (27%), Positives = 126/286 (44%), Gaps = 16/286 (5%)
Query: 27 ELSGPGPYRQ----ADRYGFIGGSSAEPGPGHPPADLIRQ--REMKWVEMTSHWEKTMSR 80
E GP P+R D G + + P + R+ R+ KWV+M WEK S
Sbjct: 32 EDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSS 91
Query: 81 RYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAE-APGDPQWMETIGRDL 139
R K+ + KG+P +R W +L + +PG YQ + E + ++ I RD+
Sbjct: 92 R--KLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDI 149
Query: 140 HRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWC 199
H F G Q+ LL +L AY Y PE GYC+ +AA+ L++LP E+AFW
Sbjct: 150 SGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWA 209
Query: 200 LVQIC---EVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWF 256
LVQ+ L G++ P+ V+ + ++ P H + +
Sbjct: 210 LVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCL 269
Query: 257 LCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQR 302
+ + + LR+WD +L EG + L + + R+A ++R
Sbjct: 270 IRILIDGISLGLTLRLWDVYLVEGEQAL----MPITRIAFKVQQKR 311
>gi|157502205 TBC1 domain family, member 3G [Homo sapiens]
Length = 549
Score = 105 bits (261), Expect = 1e-22
Identities = 78/286 (27%), Positives = 126/286 (44%), Gaps = 16/286 (5%)
Query: 27 ELSGPGPYRQ----ADRYGFIGGSSAEPGPGHPPADLIRQ--REMKWVEMTSHWEKTMSR 80
E GP P+R D G + + P + R+ R+ KWV+M WEK S
Sbjct: 32 EDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSS 91
Query: 81 RYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAE-APGDPQWMETIGRDL 139
R K+ + KG+P +R W +L + +PG YQ + E + ++ I RD+
Sbjct: 92 R--KLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDI 149
Query: 140 HRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWC 199
H F G Q+ LL +L AY Y PE GYC+ +AA+ L++LP E+AFW
Sbjct: 150 SGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWA 209
Query: 200 LVQIC---EVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWF 256
LVQ+ L G++ P+ V+ + ++ P H + +
Sbjct: 210 LVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCL 269
Query: 257 LCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQR 302
+ + + LR+WD +L EG + L + + R+A ++R
Sbjct: 270 IRILIDGISLGLTLRLWDVYLVEGEQAL----MPITRIAFKVQQKR 311
>gi|14149985 TBC1 domain family, member 3F [Homo sapiens]
Length = 549
Score = 104 bits (260), Expect = 1e-22
Identities = 78/286 (27%), Positives = 126/286 (44%), Gaps = 16/286 (5%)
Query: 27 ELSGPGPYRQ----ADRYGFIGGSSAEPGPGHPPADLIRQ--REMKWVEMTSHWEKTMSR 80
E GP P+R D G + + P + R+ R+ KWV+M WEK S
Sbjct: 32 EDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSS 91
Query: 81 RYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAE-APGDPQWMETIGRDL 139
R K+ + KG+P +R W +L + +PG YQ + E + ++ I RD+
Sbjct: 92 R--KLIDRAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKKSSEHIQRIDRDV 149
Query: 140 HRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWC 199
H F G Q+ LL +L AY Y PE GYC+ +AA+ L++LP E+AFW
Sbjct: 150 SGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWA 209
Query: 200 LVQIC---EVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWF 256
LVQ+ L G++ P+ V+ + ++ P H + +
Sbjct: 210 LVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCL 269
Query: 257 LCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQR 302
+ + + LR+WD +L EG + L + + R+A ++R
Sbjct: 270 IRILIDGISLGLTLRLWDVYLVEGEQAL----MPITRIAFKVQQKR 311
>gi|183583565 TBC1 domain family, member 3 [Homo sapiens]
Length = 549
Score = 104 bits (259), Expect = 2e-22
Identities = 78/286 (27%), Positives = 126/286 (44%), Gaps = 16/286 (5%)
Query: 27 ELSGPGPYRQ----ADRYGFIGGSSAEPGPGHPPADLIRQ--REMKWVEMTSHWEKTMSR 80
E GP P+R D G + + P + R+ R+ KWV+M WEK S
Sbjct: 32 EDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSS 91
Query: 81 RYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAE-APGDPQWMETIGRDL 139
R K+ + KG+P +R W +L + +PG YQ + E + ++ I RD+
Sbjct: 92 R--KLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDV 149
Query: 140 HRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWC 199
H F G Q+ LL +L AY Y PE GYC+ +AA+ L++LP E+AFW
Sbjct: 150 SGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWA 209
Query: 200 LVQIC---EVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWF 256
LVQ+ L G++ P+ V+ + ++ P H + +
Sbjct: 210 LVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCL 269
Query: 257 LCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQR 302
+ + + LR+WD +L EG + L + + R+A ++R
Sbjct: 270 IRILIDGISLGLTLRLWDVYLVEGEQAL----MPITRIAFKVQQKR 311
>gi|183583567 TBC1 domain family, member 3E [Homo sapiens]
Length = 549
Score = 104 bits (259), Expect = 2e-22
Identities = 78/286 (27%), Positives = 126/286 (44%), Gaps = 16/286 (5%)
Query: 27 ELSGPGPYRQ----ADRYGFIGGSSAEPGPGHPPADLIRQ--REMKWVEMTSHWEKTMSR 80
E GP P+R D G + + P + R+ R+ KWV+M WEK S
Sbjct: 32 EDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSS 91
Query: 81 RYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAE-APGDPQWMETIGRDL 139
R K+ + KG+P +R W +L + +PG YQ + E + ++ I RD+
Sbjct: 92 R--KLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDV 149
Query: 140 HRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWC 199
H F G Q+ LL +L AY Y PE GYC+ +AA+ L++LP E+AFW
Sbjct: 150 SGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWA 209
Query: 200 LVQIC---EVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWF 256
LVQ+ L G++ P+ V+ + ++ P H + +
Sbjct: 210 LVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCL 269
Query: 257 LCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQR 302
+ + + LR+WD +L EG + L + + R+A ++R
Sbjct: 270 IRILIDGISLGLTLRLWDVYLVEGEQAL----MPITRIAFKVQQKR 311
>gi|183583563 TBC1 domain family, member 3D [Homo sapiens]
Length = 549
Score = 104 bits (259), Expect = 2e-22
Identities = 78/286 (27%), Positives = 126/286 (44%), Gaps = 16/286 (5%)
Query: 27 ELSGPGPYRQ----ADRYGFIGGSSAEPGPGHPPADLIRQ--REMKWVEMTSHWEKTMSR 80
E GP P+R D G + + P + R+ R+ KWV+M WEK S
Sbjct: 32 EDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSS 91
Query: 81 RYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAE-APGDPQWMETIGRDL 139
R K+ + KG+P +R W +L + +PG YQ + E + ++ I RD+
Sbjct: 92 R--KLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDV 149
Query: 140 HRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWC 199
H F G Q+ LL +L AY Y PE GYC+ +AA+ L++LP E+AFW
Sbjct: 150 SGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWA 209
Query: 200 LVQIC---EVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWF 256
LVQ+ L G++ P+ V+ + ++ P H + +
Sbjct: 210 LVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCL 269
Query: 257 LCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQR 302
+ + + LR+WD +L EG + L + + R+A ++R
Sbjct: 270 IRILIDGISLGLTLRLWDVYLVEGEQAL----MPITRIAFKVQQKR 311
>gi|149999613 TBC1 domain family, member 3B [Homo sapiens]
Length = 549
Score = 103 bits (258), Expect = 2e-22
Identities = 81/290 (27%), Positives = 126/290 (43%), Gaps = 24/290 (8%)
Query: 27 ELSGPGPYRQ----ADRYGFIGGSSAEPGPGHPPADLIRQ--REMKWVEMTSHWEKTMSR 80
E GP P+R D G + + P + R+ R+ KWV+M WEK S
Sbjct: 32 EDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSS 91
Query: 81 RYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAE-APGDPQWMETIGRDL 139
R K+ + KG+P +R W +L + +PG YQ + E + ++ I RD+
Sbjct: 92 R--KLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDI 149
Query: 140 HRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWC 199
H F G Q+ LL +L AY Y PE GYC+ +AA+ L++ P E+AFW
Sbjct: 150 SGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYFPEEDAFWA 209
Query: 200 LVQIC---EVYLPGYYGPHMEAVR----LDAEVFMALLRRLLPHVHKHLQQVGVGPLLYL 252
LVQ+ L G++ P+ V+ V + + H K PL L
Sbjct: 210 LVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQSKTMGHQDKKDLCGQCSPLGCL 269
Query: 253 PEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQR 302
+ + + LR+WD +L EG + L + + R+A ++R
Sbjct: 270 ----IRILIDGISLGLTLRLWDVYLVEGEQAL----MPITRIAFKVQQKR 311
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 102 bits (255), Expect = 5e-22
Identities = 73/244 (29%), Positives = 110/244 (45%), Gaps = 27/244 (11%)
Query: 69 EMTSHWEKTMSRRYKKVKMQC-------RKGIPSALRARCWPLLCGAHVCQKNSPGTYQE 121
E+ W+K + K++ ++G+P + R W L + + P Q
Sbjct: 888 EVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQ- 946
Query: 122 LAEAPGDPQWMETIGR----------DLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYR 171
P D + E + + DL R FP H F G GQ L +LKAY+L
Sbjct: 947 ----PPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLD 1002
Query: 172 PEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGY---YGPHMEAVRLDAEVFMA 228
E GYCQ VA VLL+H+ E+AF L + +Y G+ Y P M ++++
Sbjct: 1003 KEVGYCQGISFVAGVLLLHMSEEQAFEMLKFL--MYDLGFRKQYRPDMMSLQIQMYQLSR 1060
Query: 229 LLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVG 288
LL ++ HL++ + P LY WFL LFA V RV+D +G V+F+V
Sbjct: 1061 LLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVA 1120
Query: 289 LTLV 292
L+L+
Sbjct: 1121 LSLL 1124
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.139 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,516,227
Number of Sequences: 37866
Number of extensions: 1260399
Number of successful extensions: 5868
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 78
Number of HSP's successfully gapped in prelim test: 183
Number of HSP's that attempted gapping in prelim test: 5431
Number of HSP's gapped (non-prelim): 527
length of query: 446
length of database: 18,247,518
effective HSP length: 105
effective length of query: 341
effective length of database: 14,271,588
effective search space: 4866611508
effective search space used: 4866611508
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.