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Search of human proteins with 38348344
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38348344 hypothetical protein LOC374355 [Homo sapiens]
(258 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38348344 hypothetical protein LOC374355 [Homo sapiens] 498 e-141
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 64 1e-10
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 58 7e-09
gi|215982794 myosin VA isoform 2 [Homo sapiens] 57 1e-08
gi|215982791 myosin VA isoform 1 [Homo sapiens] 57 1e-08
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 57 1e-08
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 57 1e-08
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 57 2e-08
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 57 2e-08
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 57 2e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 56 4e-08
gi|55770834 centromere protein F [Homo sapiens] 55 5e-08
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 55 6e-08
gi|170784854 PTPRF interacting protein, binding protein 2 (lipri... 54 1e-07
gi|190341068 forkhead-associated (FHA) phosphopeptide binding do... 54 1e-07
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 54 1e-07
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo... 54 2e-07
gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo... 54 2e-07
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 54 2e-07
gi|124249396 coiled-coil domain containing 30 [Homo sapiens] 53 2e-07
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 53 2e-07
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens] 53 3e-07
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens] 53 3e-07
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 52 4e-07
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 52 4e-07
gi|157785668 coiled-coil domain containing 39 [Homo sapiens] 52 4e-07
gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 52 5e-07
gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 52 5e-07
gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 52 5e-07
gi|112420968 coiled-coil domain containing 158 [Homo sapiens] 52 5e-07
>gi|38348344 hypothetical protein LOC374355 [Homo sapiens]
Length = 258
Score = 498 bits (1283), Expect = e-141
Identities = 258/258 (100%), Positives = 258/258 (100%)
Query: 1 MSLESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFF 60
MSLESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFF
Sbjct: 1 MSLESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFF 60
Query: 61 EKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYE 120
EKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYE
Sbjct: 61 EKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYE 120
Query: 121 ITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQR 180
ITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQR
Sbjct: 121 ITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQR 180
Query: 181 KLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQT 240
KLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQT
Sbjct: 181 KLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQT 240
Query: 241 EIEFLELTLAQKDLQESK 258
EIEFLELTLAQKDLQESK
Sbjct: 241 EIEFLELTLAQKDLQESK 258
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 64.3 bits (155), Expect = 1e-10
Identities = 66/256 (25%), Positives = 115/256 (44%), Gaps = 22/256 (8%)
Query: 14 EHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHE 73
E + EE + +++E + ++ I++ E+L EE+ + + L+ L+ +
Sbjct: 921 EARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQ 980
Query: 74 NALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYE--ITKKRELLMKE 131
LE Q ++ + +L + EEE+K K + N +E IT E L +E
Sbjct: 981 IILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK-SKSLAKLKNKHEAMITDLEERLRRE 1039
Query: 132 NVKIEISDLENQANMLKSEMKSMEHDSS----QLNELQKQKSELIQELF----TLQRKLK 183
E Q L+ + +E DS+ Q+ ELQ Q +EL +L LQ L
Sbjct: 1040 ---------EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALA 1090
Query: 184 VFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEIE 243
E+E + K + + +ISE Q D E R + ++ D+ EAL+TE+E
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISEL-QEDLESERASRNKAEKQKRDLGEELEALKTELE 1149
Query: 244 -FLELTLAQKDLQESK 258
L+ T AQ++L+ +
Sbjct: 1150 DTLDSTAAQQELRSKR 1165
Score = 48.1 bits (113), Expect = 7e-06
Identities = 57/274 (20%), Positives = 126/274 (45%), Gaps = 41/274 (14%)
Query: 18 EESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHEN--A 75
EE R + R E+ + R K++ + +L+++ +L++++ + +QL K E A
Sbjct: 1033 EERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELK-----MQLAKKEEELQA 1087
Query: 76 LEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMK-ENVK 134
+ E +NM L+ ++ Q+ E ++ E N + +KR+L + E +K
Sbjct: 1088 ALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEK--QKRDLGEELEALK 1145
Query: 135 IEISDL--------------ENQANMLKS--EMKSMEHDSSQLNELQKQKSELIQEL--- 175
E+ D E + N+LK E ++ H++ Q+ E++++ S+ ++EL
Sbjct: 1146 TELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA-QIQEMRQKHSQAVEELAEQ 1204
Query: 176 FTLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYK-------- 227
+++K ++ +++ + A ++K+ + + D+E R K E +L +
Sbjct: 1205 LEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEG 1264
Query: 228 ---EDDMESVYEALQTEIEFLELTLAQKDLQESK 258
++ LQ E++ + L+Q D + SK
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSK 1298
Score = 45.1 bits (105), Expect = 6e-05
Identities = 64/283 (22%), Positives = 111/283 (39%), Gaps = 49/283 (17%)
Query: 8 QHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEE----------LNEEKIKLESKVQ 57
Q+I E Q EE ++++ E K+KK EE L +EK LE ++
Sbjct: 943 QNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIA 1002
Query: 58 QFF-------EKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIK 110
+F EKS L LK A+ E Q E ++++ +
Sbjct: 1003 EFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSD 1062
Query: 111 EITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQ----- 165
+I + K + +E ++ ++ +E +A +K + SQ++ELQ
Sbjct: 1063 QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLES 1122
Query: 166 ---------KQKSELIQELFTLQRKLKVFED-----------EENESICTTKYLEAE--- 202
KQK +L +EL L+ +L+ D E E K LE E
Sbjct: 1123 ERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKT 1182
Query: 203 -KIKISEKPQNDTECL-RLKKELELYK--EDDMESVYEALQTE 241
+ +I E Q ++ + L ++LE K + ++E + L+ E
Sbjct: 1183 HEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE 1225
Score = 44.3 bits (103), Expect = 1e-04
Identities = 50/237 (21%), Positives = 107/237 (45%), Gaps = 39/237 (16%)
Query: 29 SEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITNHRN 88
++I R+K +A EEL E+ ++ +V+ EK+ + LE + E+ N
Sbjct: 1185 AQIQEMRQKHSQAVEELAEQ-LEQTKRVKANLEKA---------KQTLENERGELANEVK 1234
Query: 89 MLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEI-TKKRELLMKENVKIE-----ISDLEN 142
+LLQ + + + E + + FN + T+ + + K V+++ +S ++
Sbjct: 1235 VLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDS 1294
Query: 143 QANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEEN------------ 190
+++ L + ++E SQL + Q+ E ++ +L KLK EDE+N
Sbjct: 1295 KSSKLTKDFSALE---SQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEA 1351
Query: 191 -----ESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEI 242
+ I T L A+ + +K ++ CL +E++ + D+E + + + ++
Sbjct: 1352 KHNLEKQIAT---LHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKV 1405
Score = 43.9 bits (102), Expect = 1e-04
Identities = 54/255 (21%), Positives = 105/255 (41%), Gaps = 28/255 (10%)
Query: 16 QAEESRRLMREVRSEITRCREKIKKATEELNE----------EKIKLESKVQQFFEKSFF 65
Q M E+ + REK A L E EK++L+ ++Q E
Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898
Query: 66 LQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKR 125
+ L+A A +++ EI + ++ E + + E+ K + I + E
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE----E 954
Query: 126 ELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVF 185
E ++ +++E E + L+ E +E + +L + +K + I E T +
Sbjct: 955 EESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTE---- 1010
Query: 186 EDEENESICTTKYLE-------AEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEAL 238
E+E+++S+ K E+++ EK + + E R K E + D+ L
Sbjct: 1011 EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGD---STDLSDQIAEL 1067
Query: 239 QTEIEFLELTLAQKD 253
Q +I L++ LA+K+
Sbjct: 1068 QAQIAELKMQLAKKE 1082
Score = 38.9 bits (89), Expect = 0.004
Identities = 52/230 (22%), Positives = 98/230 (42%), Gaps = 18/230 (7%)
Query: 14 EHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHE 73
E E R+L +++ R EK+ A ++L + K +L+ ++ + L +
Sbjct: 1381 ETAEEVKRKLQKDLEGLSQRHEEKVA-AYDKLEKTKTRLQQELDDLL-----VDLDHQRQ 1434
Query: 74 NA--LEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKE 131
+A LEK+ + + LL + I + EE D+ E + ++ R L
Sbjct: 1435 SACNLEKKQKKF----DQLLAEEKTISAKYAEERDRAEAEARE-KETKALSLARALEEAM 1489
Query: 132 NVKIEISDLENQANMLKSEMKSMEHD-SSQLNELQKQKSELIQELFTLQRKLKVFEDE-- 188
K E+ L Q ++ S + D ++EL+K K L Q++ ++ +L+ EDE
Sbjct: 1490 EQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQ 1549
Query: 189 --ENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYE 236
E+ + L+A K + Q E KK+ + + +ME+ E
Sbjct: 1550 ATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELE 1599
Score = 31.2 bits (69), Expect = 0.93
Identities = 22/89 (24%), Positives = 44/89 (49%), Gaps = 6/89 (6%)
Query: 161 LNELQKQKSELI---QELFTLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECL 217
L ++ +Q+ E++ +EL ++ K E+ E L AEK+++ E+ Q +TE
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896
Query: 218 RLKKELE---LYKEDDMESVYEALQTEIE 243
+EL K+ ++E + L+ +E
Sbjct: 897 AEAEELRARLTAKKQELEEICHDLEARVE 925
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 58.2 bits (139), Expect = 7e-09
Identities = 62/258 (24%), Positives = 121/258 (46%), Gaps = 21/258 (8%)
Query: 3 LESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEK 62
+E L + + E Q EE ++ +++EI + ++++ + EL + KLE+ QF +
Sbjct: 440 VEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDS 499
Query: 63 SFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEIT 122
+++LK A E+ R +LQT + +EE++ + + T D
Sbjct: 500 KQHIEVLKESLTAKEQ--------RAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEE 551
Query: 123 KKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKL 182
K + ++K + E + N+L+ K +E+ QL + +KQ S L + + +LQ
Sbjct: 552 KGTQAGEIHDLKDMLDVKERKVNVLQ---KKIENLQEQLRDKEKQMSSLKERVKSLQAD- 607
Query: 183 KVFEDEENESICTTKYLEAEKIKISE--KPQNDTECLRLKKELELYKED--DMESVYEAL 238
+ ++ T + AEK + E K Q D + ++E++ YK+D D++ L
Sbjct: 608 ---TTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLL 664
Query: 239 QTEIEFLELTLAQKDLQE 256
Q ++ E +L DL+E
Sbjct: 665 QGDLSEKEASLL--DLKE 680
Score = 42.4 bits (98), Expect = 4e-04
Identities = 49/224 (21%), Positives = 100/224 (44%), Gaps = 30/224 (13%)
Query: 41 ATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQ 100
A E+ EE +K+ES QL KAHE ALE + S + R + ++++
Sbjct: 702 ALEQKKEECLKMES------------QLKKAHEAALEARASPEMSDR------IQHLERE 743
Query: 101 MIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQ--------ANMLKSEMK 152
+ +D+ K + + EI K+ E + K +I++LE Q AN+ E
Sbjct: 744 ITRYKDESSKAQAEVDRLLEILKEVENEKNDKDK-KIAELERQVKDQNKKVANLKHKEQV 802
Query: 153 SMEHDSSQLNELQKQKSELIQELFTLQRKLKVFED---EENESICTTKYLEAEKIKISEK 209
+ + L E ++++ L LQ L+ +D E E++ + + AE+ + +
Sbjct: 803 EKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQ 862
Query: 210 PQNDTECLRLKKELELYKEDDMESVYEALQTEIEFLELTLAQKD 253
++ + E L + ++ E+++ ++ + +LA+K+
Sbjct: 863 EESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKE 906
Score = 37.7 bits (86), Expect = 0.010
Identities = 47/236 (19%), Positives = 101/236 (42%), Gaps = 37/236 (15%)
Query: 26 EVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYS---- 81
+ ++E+ R E +K+ E N++ K+ +Q +++ + LK H+ +EK+ S
Sbjct: 753 KAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLK-HKEQVEKKKSAQML 811
Query: 82 -EITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDL 140
E + L + + ++ + +++D+ + +IT +RE+++ +
Sbjct: 812 EEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQ--------- 862
Query: 141 ENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLE 200
E + + Q+ EL ++ QEL +++ KL + E L
Sbjct: 863 ---------EESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLR 913
Query: 201 AEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEIEFLELTLAQKDLQE 256
AE+ K L++ LE+ +E + ++ E I LEL+ ++K QE
Sbjct: 914 AERRK------------HLEEVLEMKQEALLAAISEK-DANIALLELSSSKKKTQE 956
>gi|215982794 myosin VA isoform 2 [Homo sapiens]
Length = 1828
Score = 57.4 bits (137), Expect = 1e-08
Identities = 60/277 (21%), Positives = 120/277 (43%), Gaps = 27/277 (9%)
Query: 3 LESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEK 62
L S + + +E +A+ + + ++ EI K++K E+ EK +E ++ ++
Sbjct: 964 LRSDLERLQLSEEEAKVATGRVLSLQEEIA----KLRKDLEQTRSEKKCIEEHADRYKQE 1019
Query: 63 SFFLQLLKAHENALEKQYSEITNHR--NMLLQTFEAIKKQMIEEEDKFIKEITD------ 114
+ L EN L KQ E NHR + E ++K+++EE + ++ D
Sbjct: 1020 TEQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTETMEKKLVEETKQLELDLNDERLRYQ 1079
Query: 115 -FNNDYEITKKRELLMKENVKIEI---------SDLENQAN----MLKSEMKSMEHDSSQ 160
N++ ++R +KE + + + +D + +N + SE+ ME S+
Sbjct: 1080 NLLNEFSRLEERYDDLKEEMTLMVHVPKPGHKRTDSTHSSNESEYIFSSEIAEMEDIPSR 1139
Query: 161 LNELQKQKSELIQELF-TLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRL 219
E ++K L LF LQ+++ E E+ E + ++ K + +
Sbjct: 1140 TEEPSEKKVPLDMSLFLKLQKRVTELEQEKQVMQDELDRKEEQVLRSKAKEEERPQIRGA 1199
Query: 220 KKELELYKEDDMESVYEALQTEIEFLELTLAQKDLQE 256
+ E E K ++ES + L+ E+ L L++K E
Sbjct: 1200 ELEYESLKRQELESENKKLKNELNELRKALSEKSAPE 1236
Score = 29.3 bits (64), Expect = 3.6
Identities = 28/114 (24%), Positives = 56/114 (49%), Gaps = 11/114 (9%)
Query: 146 MLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIK 205
M K E+K ++ ++ + +K + ++ LQRK+ DE+N+ K L +
Sbjct: 900 MAKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKV----DEQNKDY---KCLVEKLTN 952
Query: 206 ISEKPQNDTECLRLKKE-LELYKEDDMESVYEALQTEIEFLELTLAQKDLQESK 258
+ ++TE LR E L+L +E+ + L + E +L +KDL++++
Sbjct: 953 LEGIYNSETEKLRSDLERLQLSEEEAKVATGRVLSLQEEIAKL---RKDLEQTR 1003
>gi|215982791 myosin VA isoform 1 [Homo sapiens]
Length = 1855
Score = 57.4 bits (137), Expect = 1e-08
Identities = 60/277 (21%), Positives = 120/277 (43%), Gaps = 27/277 (9%)
Query: 3 LESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEK 62
L S + + +E +A+ + + ++ EI K++K E+ EK +E ++ ++
Sbjct: 964 LRSDLERLQLSEEEAKVATGRVLSLQEEIA----KLRKDLEQTRSEKKCIEEHADRYKQE 1019
Query: 63 SFFLQLLKAHENALEKQYSEITNHR--NMLLQTFEAIKKQMIEEEDKFIKEITD------ 114
+ L EN L KQ E NHR + E ++K+++EE + ++ D
Sbjct: 1020 TEQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTETMEKKLVEETKQLELDLNDERLRYQ 1079
Query: 115 -FNNDYEITKKRELLMKENVKIEI---------SDLENQAN----MLKSEMKSMEHDSSQ 160
N++ ++R +KE + + + +D + +N + SE+ ME S+
Sbjct: 1080 NLLNEFSRLEERYDDLKEEMTLMVHVPKPGHKRTDSTHSSNESEYIFSSEIAEMEDIPSR 1139
Query: 161 LNELQKQKSELIQELF-TLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRL 219
E ++K L LF LQ+++ E E+ E + ++ K + +
Sbjct: 1140 TEEPSEKKVPLDMSLFLKLQKRVTELEQEKQVMQDELDRKEEQVLRSKAKEEERPQIRGA 1199
Query: 220 KKELELYKEDDMESVYEALQTEIEFLELTLAQKDLQE 256
+ E E K ++ES + L+ E+ L L++K E
Sbjct: 1200 ELEYESLKRQELESENKKLKNELNELRKALSEKSAPE 1236
Score = 29.3 bits (64), Expect = 3.6
Identities = 28/114 (24%), Positives = 56/114 (49%), Gaps = 11/114 (9%)
Query: 146 MLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIK 205
M K E+K ++ ++ + +K + ++ LQRK+ DE+N+ K L +
Sbjct: 900 MAKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKV----DEQNKDY---KCLVEKLTN 952
Query: 206 ISEKPQNDTECLRLKKE-LELYKEDDMESVYEALQTEIEFLELTLAQKDLQESK 258
+ ++TE LR E L+L +E+ + L + E +L +KDL++++
Sbjct: 953 LEGIYNSETEKLRSDLERLQLSEEEAKVATGRVLSLQEEIAKL---RKDLEQTR 1003
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 57.4 bits (137), Expect = 1e-08
Identities = 53/222 (23%), Positives = 100/222 (45%), Gaps = 26/222 (11%)
Query: 19 ESRRLMREVRS--EITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENAL 76
E+R+L + + S +T E ++K +L+EE ++L V+ S + L+ L
Sbjct: 671 ENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKEL 730
Query: 77 EKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKI- 135
E + ++ +L +F+ ++ E++ D E + ++ L N KI
Sbjct: 731 ESEKEQLKKGLELLKASFKKTERL----------EVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 136 ----EISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDE--- 188
E+ DLE + L+ ++ ++ S +L +L+K+ L QE L++ K E E
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 189 -ENESICTTKYLEAEKIKISE-KPQNDTECLRLKKELELYKE 228
++ LE +KI + +N T L KE+ +YKE
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKT----LSKEIGIYKE 878
Score = 56.2 bits (134), Expect = 3e-08
Identities = 63/267 (23%), Positives = 129/267 (48%), Gaps = 33/267 (12%)
Query: 4 ESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKL-ESKVQQFFEK 62
E L + T+ + +L E+ +I +E++ + ++ + KL ESK++ +K
Sbjct: 909 EDLVSEKLKTQQMNNDLEKLTHELE-KIGLNKERLLHDEQSTDDSRYKLLESKLESTLKK 967
Query: 63 SFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKK-----QMIEEEDKFIKE---ITD 114
S L++ + ALE + E TN+ L Q + +KK + ++E++ ++ I+
Sbjct: 968 S--LEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISG 1025
Query: 115 FNNDYEITKK---RELLMKENVKIEI----SDLENQANMLKSEMKSMEHDS----SQLNE 163
+N +E + RELL ++ IE+ + L+ + LK+++K +E + +Q+
Sbjct: 1026 EDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILA 1085
Query: 164 LQKQKSELIQELFTLQ---RKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLK 220
LQ+Q L ++ TLQ KL+V N + A+ + +N+ E +
Sbjct: 1086 LQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV--- 1142
Query: 221 KELELYKEDDMESVYEALQTEIEFLEL 247
+ + +D++S+Y++L + E LEL
Sbjct: 1143 ----IKEREDLKSLYDSLIKDHEKLEL 1165
Score = 50.8 bits (120), Expect = 1e-06
Identities = 62/264 (23%), Positives = 120/264 (45%), Gaps = 37/264 (14%)
Query: 20 SRRLMRE---VRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFF-----LQLLKA 71
S+ LM+E + I RE ++ + L +E L V ++S ++ ++
Sbjct: 528 SKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEK 587
Query: 72 HENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKE 131
L + E ++ + + IKK++ ++K + N + + K+ ELL K+
Sbjct: 588 ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKK 647
Query: 132 --NVKI----------EISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQ 179
N+KI E S+LE + LK + S ++ + QL L+K+ S+L +E L+
Sbjct: 648 ITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELR 707
Query: 180 RKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELY-----KEDDMESV 234
R ++ + C + + ++ E + ++E +LKK LEL K + +E
Sbjct: 708 RNVESLK-------CASMKMAQLQL---ENKELESEKEQLKKGLELLKASFKKTERLEVS 757
Query: 235 YEALQTEIEFLELTL--AQKDLQE 256
Y+ L E + L+ TL + K +Q+
Sbjct: 758 YQGLDIENQRLQKTLENSNKKIQQ 781
Score = 47.0 bits (110), Expect = 2e-05
Identities = 49/217 (22%), Positives = 102/217 (47%), Gaps = 29/217 (13%)
Query: 36 EKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFE 95
++++K E N++ +LES++Q ++ LQ K+ ++ L Q
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS 825
Query: 96 AIKK--QMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKS 153
++K + +E+E+K +++ + ++ ++EN ++I +LE + L E+
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEI---------KDTTLEEN-NVKIGNLEKENKTLSKEIGI 875
Query: 154 MEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKIS------ 207
+ +L EL+K+ EL++ T+ K V E+ L +EK+K
Sbjct: 876 YKESCVRLKELEKENKELVKRA-TIDIKTLVTLRED---------LVSEKLKTQQMNNDL 925
Query: 208 EKPQNDTECLRLKKELELYKEDDM-ESVYEALQTEIE 243
EK ++ E + L KE L+ E +S Y+ L++++E
Sbjct: 926 EKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLE 962
Score = 42.0 bits (97), Expect = 5e-04
Identities = 54/261 (20%), Positives = 117/261 (44%), Gaps = 39/261 (14%)
Query: 22 RLMREVRSEITRCREK--IKKATEELNEEKIKLESKVQQFFEKSFFLQ-----------L 68
RL+ R+ T EK +K ++L + L++++ ++ LQ
Sbjct: 1047 RLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAK 1106
Query: 69 LKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDK-FIKEITDFNNDYE-ITKKRE 126
L+ + L Q + + N LL I++ +E E++ IKE D + Y+ + K E
Sbjct: 1107 LQVENSTLNSQSTSLMNQNAQLL-----IQQSSLENENESVIKEREDLKSLYDSLIKDHE 1161
Query: 127 LL--MKENVKIEISDLENQANMLKSEMKSMEHDSSQL----NELQKQKSEL--IQELFTL 178
L + E E L ++ LKS K++E + L N+L KQK +L ++++ +
Sbjct: 1162 KLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKV 1221
Query: 179 QRKLKVFEDEENESICT-----------TKYLEAEKIKISEKPQNDTECLRLKKELELYK 227
+++ + E++ +E++ + ++ +K +E Q D + L+ +
Sbjct: 1222 EQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE 1281
Query: 228 EDDMESVYEALQTEIEFLELT 248
+ +E+ + L+ + + L++T
Sbjct: 1282 QTRLEAEFSKLKEQYQQLDIT 1302
Score = 38.5 bits (88), Expect = 0.006
Identities = 54/235 (22%), Positives = 100/235 (42%), Gaps = 35/235 (14%)
Query: 3 LESLFQHIIFTEHQAEE--SRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFF 60
L+SL+ +I +H+ E R E S I++ +K A + L E LE + Q
Sbjct: 1149 LKSLYDSLI-KDHEKLELLHERQASEYESLISK-HGTLKSAHKNLEVEHRDLEDRYNQLL 1206
Query: 61 EKSFFLQ-LLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDY 119
++ L+ L K + EK E NH +T A K++ E D+ + +
Sbjct: 1207 KQKGQLEDLEKMLKVEQEKMLLENKNH-----ETVAAEYKKLCGENDRLNHTYSQLLKET 1261
Query: 120 EITKKRELLMKE---NVKIEISDLENQANMLKSEMKSMEHDSSQLN-----------ELQ 165
E+ + +K N K+E + LE + + LK + + ++ S++LN L+
Sbjct: 1262 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLE 1321
Query: 166 KQKSELIQELFTLQRKLK-----------VFEDEENESICTTKYLEAEKIKISEK 209
++ L+ ++ TL + + +F E+ + I L +K K+ EK
Sbjct: 1322 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1376
Score = 38.1 bits (87), Expect = 0.008
Identities = 51/249 (20%), Positives = 110/249 (44%), Gaps = 40/249 (16%)
Query: 24 MREVRSEITRCREKIKKATEELNE-----EKIKLESKVQQFFEKSFF------------L 66
+ + +++I R R+++++ TE+L + E++++E K Q + L
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL 312
Query: 67 QLLKAHENALEKQYSEITNHRNML--LQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKK 124
L+ ++K SE++ ++ L ++ ++A +++ E+ ++ T + E T+
Sbjct: 313 DALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372
Query: 125 RE----LLMKENV--KIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTL 178
R L KEN+ K ++ D+E + +M + +++ + ++ L QKQ + L
Sbjct: 373 RSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL--- 429
Query: 179 QRKLKVFEDEENESICTTKYL-EAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEA 237
E E I T L EA + + + T LK E+E + E
Sbjct: 430 --------GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME---NQSLTKTVEE 478
Query: 238 LQTEIEFLE 246
L+T ++ +E
Sbjct: 479 LRTTVDSVE 487
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 57.4 bits (137), Expect = 1e-08
Identities = 53/222 (23%), Positives = 100/222 (45%), Gaps = 26/222 (11%)
Query: 19 ESRRLMREVRS--EITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENAL 76
E+R+L + + S +T E ++K +L+EE ++L V+ S + L+ L
Sbjct: 671 ENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKEL 730
Query: 77 EKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKI- 135
E + ++ +L +F+ ++ E++ D E + ++ L N KI
Sbjct: 731 ESEKEQLKKGLELLKASFKKTERL----------EVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 136 ----EISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDE--- 188
E+ DLE + L+ ++ ++ S +L +L+K+ L QE L++ K E E
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 189 -ENESICTTKYLEAEKIKISE-KPQNDTECLRLKKELELYKE 228
++ LE +KI + +N T L KE+ +YKE
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKT----LSKEIGIYKE 878
Score = 55.8 bits (133), Expect = 4e-08
Identities = 62/266 (23%), Positives = 127/266 (47%), Gaps = 32/266 (12%)
Query: 4 ESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKS 63
E L + T+ + +L E+ +I +E++ + ++ LESK++ +KS
Sbjct: 909 EDLVSEKLKTQQMNNDLEKLTHELE-KIGLNKERLLHDEQSTDDRYKLLESKLESTLKKS 967
Query: 64 FFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKK-----QMIEEEDKFIKE---ITDF 115
L++ + ALE + E TN+ L Q + +KK + ++E++ ++ I+
Sbjct: 968 --LEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1025
Query: 116 NNDYEITKK---RELLMKENVKIEI----SDLENQANMLKSEMKSMEHDS----SQLNEL 164
+N +E + RELL ++ IE+ + L+ + LK+++K +E + +Q+ L
Sbjct: 1026 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL 1085
Query: 165 QKQKSELIQELFTLQ---RKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKK 221
Q+Q L ++ TLQ KL+V N + A+ + +N+ E +
Sbjct: 1086 QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV---- 1141
Query: 222 ELELYKEDDMESVYEALQTEIEFLEL 247
+ + +D++S+Y++L + E LEL
Sbjct: 1142 ---IKEREDLKSLYDSLIKDHEKLEL 1164
Score = 50.8 bits (120), Expect = 1e-06
Identities = 62/264 (23%), Positives = 120/264 (45%), Gaps = 37/264 (14%)
Query: 20 SRRLMRE---VRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFF-----LQLLKA 71
S+ LM+E + I RE ++ + L +E L V ++S ++ ++
Sbjct: 528 SKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEK 587
Query: 72 HENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKE 131
L + E ++ + + IKK++ ++K + N + + K+ ELL K+
Sbjct: 588 ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKK 647
Query: 132 --NVKI----------EISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQ 179
N+KI E S+LE + LK + S ++ + QL L+K+ S+L +E L+
Sbjct: 648 ITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELR 707
Query: 180 RKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELY-----KEDDMESV 234
R ++ + C + + ++ E + ++E +LKK LEL K + +E
Sbjct: 708 RNVESLK-------CASMKMAQLQL---ENKELESEKEQLKKGLELLKASFKKTERLEVS 757
Query: 235 YEALQTEIEFLELTL--AQKDLQE 256
Y+ L E + L+ TL + K +Q+
Sbjct: 758 YQGLDIENQRLQKTLENSNKKIQQ 781
Score = 50.1 bits (118), Expect = 2e-06
Identities = 48/216 (22%), Positives = 101/216 (46%), Gaps = 28/216 (12%)
Query: 36 EKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFE 95
++++K E N++ +LES++Q ++ LQ K+ ++ L Q
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS 825
Query: 96 AIKK--QMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKS 153
++K + +E+E+K +++ + ++ ++EN ++I +LE + L E+
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEI---------KDTTLEEN-NVKIGNLEKENKTLSKEIGI 875
Query: 154 MEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKIS------ 207
+ +L EL+K+ EL++ T+ K V E+ L +EK+K
Sbjct: 876 YKESCVRLKELEKENKELVKRA-TIDIKTLVTLRED---------LVSEKLKTQQMNNDL 925
Query: 208 EKPQNDTECLRLKKELELYKEDDMESVYEALQTEIE 243
EK ++ E + L KE L+ E + Y+ L++++E
Sbjct: 926 EKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLE 961
Score = 42.0 bits (97), Expect = 5e-04
Identities = 54/261 (20%), Positives = 117/261 (44%), Gaps = 39/261 (14%)
Query: 22 RLMREVRSEITRCREK--IKKATEELNEEKIKLESKVQQFFEKSFFLQ-----------L 68
RL+ R+ T EK +K ++L + L++++ ++ LQ
Sbjct: 1046 RLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAK 1105
Query: 69 LKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDK-FIKEITDFNNDYE-ITKKRE 126
L+ + L Q + + N LL I++ +E E++ IKE D + Y+ + K E
Sbjct: 1106 LQVENSTLNSQSTSLMNQNAQLL-----IQQSSLENENESVIKEREDLKSLYDSLIKDHE 1160
Query: 127 LL--MKENVKIEISDLENQANMLKSEMKSMEHDSSQL----NELQKQKSEL--IQELFTL 178
L + E E L ++ LKS K++E + L N+L KQK +L ++++ +
Sbjct: 1161 KLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKV 1220
Query: 179 QRKLKVFEDEENESICT-----------TKYLEAEKIKISEKPQNDTECLRLKKELELYK 227
+++ + E++ +E++ + ++ +K +E Q D + L+ +
Sbjct: 1221 EQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE 1280
Query: 228 EDDMESVYEALQTEIEFLELT 248
+ +E+ + L+ + + L++T
Sbjct: 1281 QTRLEAEFSKLKEQYQQLDIT 1301
Score = 38.5 bits (88), Expect = 0.006
Identities = 54/235 (22%), Positives = 100/235 (42%), Gaps = 35/235 (14%)
Query: 3 LESLFQHIIFTEHQAEE--SRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFF 60
L+SL+ +I +H+ E R E S I++ +K A + L E LE + Q
Sbjct: 1148 LKSLYDSLI-KDHEKLELLHERQASEYESLISK-HGTLKSAHKNLEVEHRDLEDRYNQLL 1205
Query: 61 EKSFFLQ-LLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDY 119
++ L+ L K + EK E NH +T A K++ E D+ + +
Sbjct: 1206 KQKGQLEDLEKMLKVEQEKMLLENKNH-----ETVAAEYKKLCGENDRLNHTYSQLLKET 1260
Query: 120 EITKKRELLMKE---NVKIEISDLENQANMLKSEMKSMEHDSSQLN-----------ELQ 165
E+ + +K N K+E + LE + + LK + + ++ S++LN L+
Sbjct: 1261 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLE 1320
Query: 166 KQKSELIQELFTLQRKLK-----------VFEDEENESICTTKYLEAEKIKISEK 209
++ L+ ++ TL + + +F E+ + I L +K K+ EK
Sbjct: 1321 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1375
Score = 38.1 bits (87), Expect = 0.008
Identities = 51/249 (20%), Positives = 110/249 (44%), Gaps = 40/249 (16%)
Query: 24 MREVRSEITRCREKIKKATEELNE-----EKIKLESKVQQFFEKSFF------------L 66
+ + +++I R R+++++ TE+L + E++++E K Q + L
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL 312
Query: 67 QLLKAHENALEKQYSEITNHRNML--LQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKK 124
L+ ++K SE++ ++ L ++ ++A +++ E+ ++ T + E T+
Sbjct: 313 DALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372
Query: 125 RE----LLMKENV--KIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTL 178
R L KEN+ K ++ D+E + +M + +++ + ++ L QKQ + L
Sbjct: 373 RSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL--- 429
Query: 179 QRKLKVFEDEENESICTTKYL-EAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEA 237
E E I T L EA + + + T LK E+E + E
Sbjct: 430 --------GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME---NQSLTKTVEE 478
Query: 238 LQTEIEFLE 246
L+T ++ +E
Sbjct: 479 LRTTVDSVE 487
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 56.6 bits (135), Expect = 2e-08
Identities = 63/245 (25%), Positives = 109/245 (44%), Gaps = 21/245 (8%)
Query: 19 ESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEK 78
E +RL + ++ E+ E + A ++L EK+ E+K+++F E LE
Sbjct: 969 EKKRLQQHIQ-ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLL----------LED 1017
Query: 79 QYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEIT---KKRELLMKENVKI 135
Q S+++ R +L Q EEE+K +K + YE T + L +E +
Sbjct: 1018 QNSKLSKERKLLEDRLAEFSSQAAEEEEK-VKSLNKLRLKYEATIADMEDRLRKEEKGRQ 1076
Query: 136 EISDLENQANMLKSEM-KSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESIC 194
E+ L+ + + SE+ + M + EL+ Q +E LQ L EDE
Sbjct: 1077 ELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEE---LQAALARAEDEGGARAQ 1133
Query: 195 TTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEIE-FLELTLAQKD 253
K L + ++E Q D E R+ + + D+ EAL+ E+E L+ T AQ++
Sbjct: 1134 LLKSLREAQAALAE-AQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQE 1192
Query: 254 LQESK 258
L+ +
Sbjct: 1193 LRSKR 1197
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 56.6 bits (135), Expect = 2e-08
Identities = 63/245 (25%), Positives = 109/245 (44%), Gaps = 21/245 (8%)
Query: 19 ESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEK 78
E +RL + ++ E+ E + A ++L EK+ E+K+++F E LE
Sbjct: 961 EKKRLQQHIQ-ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLL----------LED 1009
Query: 79 QYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEIT---KKRELLMKENVKI 135
Q S+++ R +L Q EEE+K +K + YE T + L +E +
Sbjct: 1010 QNSKLSKERKLLEDRLAEFSSQAAEEEEK-VKSLNKLRLKYEATIADMEDRLRKEEKGRQ 1068
Query: 136 EISDLENQANMLKSEM-KSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESIC 194
E+ L+ + + SE+ + M + EL+ Q +E LQ L EDE
Sbjct: 1069 ELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEE---LQAALARAEDEGGARAQ 1125
Query: 195 TTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEIE-FLELTLAQKD 253
K L + ++E Q D E R+ + + D+ EAL+ E+E L+ T AQ++
Sbjct: 1126 LLKSLREAQAALAE-AQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQE 1184
Query: 254 LQESK 258
L+ +
Sbjct: 1185 LRSKR 1189
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 56.6 bits (135), Expect = 2e-08
Identities = 63/245 (25%), Positives = 109/245 (44%), Gaps = 21/245 (8%)
Query: 19 ESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEK 78
E +RL + ++ E+ E + A ++L EK+ E+K+++F E LE
Sbjct: 1002 EKKRLQQHIQ-ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLL----------LED 1050
Query: 79 QYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEIT---KKRELLMKENVKI 135
Q S+++ R +L Q EEE+K +K + YE T + L +E +
Sbjct: 1051 QNSKLSKERKLLEDRLAEFSSQAAEEEEK-VKSLNKLRLKYEATIADMEDRLRKEEKGRQ 1109
Query: 136 EISDLENQANMLKSEM-KSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESIC 194
E+ L+ + + SE+ + M + EL+ Q +E LQ L EDE
Sbjct: 1110 ELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEE---LQAALARAEDEGGARAQ 1166
Query: 195 TTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEIE-FLELTLAQKD 253
K L + ++E Q D E R+ + + D+ EAL+ E+E L+ T AQ++
Sbjct: 1167 LLKSLREAQAALAE-AQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQE 1225
Query: 254 LQESK 258
L+ +
Sbjct: 1226 LRSKR 1230
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 55.8 bits (133), Expect = 4e-08
Identities = 73/299 (24%), Positives = 134/299 (44%), Gaps = 47/299 (15%)
Query: 3 LESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEK 62
+E Q ++ ++ E + E+ +E R ++ +EL E LES+V++ E+
Sbjct: 878 MERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEER 937
Query: 63 SFFLQ----LLKAHENALEKQYSEITNHRNML---LQTFEAIKKQMIEE-------EDKF 108
+ LQ ++AH LE+Q E R L T EA K+M EE KF
Sbjct: 938 NQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKF 997
Query: 109 IKE-------ITDFNN---DYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDS 158
IKE I + ++ + E K ++ ++ ISDLE + + + +E
Sbjct: 998 IKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAK 1057
Query: 159 SQLN----ELQKQKSELIQELFTLQRKLKVFEDE--------------ENESICTTKYLE 200
+L+ +LQ Q +EL ++ L+ +L E+E +N ++ + L+
Sbjct: 1058 RKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQ 1117
Query: 201 AEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEIE-FLELTLAQKDLQESK 258
A+ ++ Q D E + + ++ D+ EAL+TE+E L+ T AQ++L+ +
Sbjct: 1118 AQIAEL----QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR 1172
Score = 50.4 bits (119), Expect = 1e-06
Identities = 57/267 (21%), Positives = 120/267 (44%), Gaps = 12/267 (4%)
Query: 1 MSLESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFF 60
+SL + + + + E + +R ++ ++ + K EL + K LE +V++
Sbjct: 1486 LSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMR 1545
Query: 61 EKSFFLQ-LLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDY 119
+ L+ L+A E+A + + + + + +Q E++ IK++ + +
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAEL 1605
Query: 120 EITKKRELLM---KENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELF 176
E +K+ L K+ ++I++ DLE Q +++ K+ + QL +LQ Q + +EL
Sbjct: 1606 EDERKQRALAVASKKKMEIDLKDLEAQ---IEAANKARDEVIKQLRKLQAQMKDYQRELE 1662
Query: 177 TLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDM---ES 233
+ + ES K LEAE +++ E+ + R ++ D++ S
Sbjct: 1663 EARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSAS 1722
Query: 234 VYEALQTEIEFLELTLAQ--KDLQESK 258
AL E LE +AQ ++L+E +
Sbjct: 1723 GKSALLDEKRRLEARIAQLEEELEEEQ 1749
Score = 45.8 bits (107), Expect = 4e-05
Identities = 52/234 (22%), Positives = 106/234 (45%), Gaps = 20/234 (8%)
Query: 26 EVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITN 85
+V E+ K ++ EE N +L+++ + F E L A + LE+ ++ +
Sbjct: 870 KVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLES 929
Query: 86 H------RNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISD 139
RN +LQ + + I++ ++ + E ++ K + ++ EI
Sbjct: 930 RVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILL 989
Query: 140 LENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYL 199
LE+Q + E K ME ++ + ++ E + L ++ K +V + L
Sbjct: 990 LEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISD----------L 1039
Query: 200 EAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEIEFLELTLAQKD 253
E E++K EK + + E + K++L+ D + + E LQ +I+ L+L LA+K+
Sbjct: 1040 E-ERLKKEEKTRQELE--KAKRKLDGETTDLQDQIAE-LQAQIDELKLQLAKKE 1089
Score = 41.6 bits (96), Expect = 7e-04
Identities = 51/253 (20%), Positives = 113/253 (44%), Gaps = 18/253 (7%)
Query: 3 LESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATE---ELNEEKIKLESKVQQF 59
L+SL I+ + + S R R E ++I + L +EK +LE+++ Q
Sbjct: 1682 LKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQL 1741
Query: 60 FEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDY 119
E+ L+ +++ L ++ + T + L A ++ ++ D +++ N +
Sbjct: 1742 EEE---LEEEQSNMELLNDRFRKTTLQVDTLNAELAA-ERSAAQKSDNARQQLERQNKEL 1797
Query: 120 EITKKREL--LMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFT 177
+ K +EL +K K IS LE + L+ +++ + + N+L ++ + ++E+F
Sbjct: 1798 K-AKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFM 1856
Query: 178 L----QRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMES 233
+R ++++ ++ K L+ +++ +E+ R K + EL DD
Sbjct: 1857 QVEDERRHADQYKEQMEKANARMKQLK-RQLEEAEEEATRANASRRKLQREL---DDATE 1912
Query: 234 VYEALQTEIEFLE 246
E L E+ L+
Sbjct: 1913 ANEGLSREVSTLK 1925
Score = 37.0 bits (84), Expect = 0.017
Identities = 49/249 (19%), Positives = 98/249 (39%), Gaps = 26/249 (10%)
Query: 14 EHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHE 73
E Q ++ R+ E++ E+ K+ L + K LE+ ++ + LQ +KA
Sbjct: 1191 EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250
Query: 74 NALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENV 133
K+ + + + ++ ++ E+ K E+ +NV
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNEL------------------DNV 1292
Query: 134 KIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESI 193
+ + E + + S+E SQL + Q+ E ++ L +++ E+E+N S+
Sbjct: 1293 STLLEEAEKKGIKFAKDAASLE---SQLQDTQELLQEETRQKLNLSSRIRQLEEEKN-SL 1348
Query: 194 CTTKYLEAEKIKISEKP----QNDTECLRLKKELELYKEDDMESVYEALQTEIEFLELTL 249
+ E E K EK Q+ + K + +L + +E + L + E L L
Sbjct: 1349 QEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL 1408
Query: 250 AQKDLQESK 258
+K L K
Sbjct: 1409 EEKALAYDK 1417
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 55.5 bits (132), Expect = 5e-08
Identities = 64/268 (23%), Positives = 111/268 (41%), Gaps = 30/268 (11%)
Query: 16 QAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAH--- 72
QA+ +++ ++T +++++ EE ++ + E Q K L+
Sbjct: 427 QAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKK 486
Query: 73 ENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYE---------ITK 123
EN L K +SE L+ KQ + + F +E+ N E I +
Sbjct: 487 ENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQ 546
Query: 124 KRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNE-LQKQKSELIQELFTLQRKL 182
+ L E +K+ ++DLE Q + + +K EH QLN+ L K + E L L+ K
Sbjct: 547 QENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKK 606
Query: 183 KVFED------------EENESICTTKYLEAEKIKISEKPQNDTECLRLKK-ELELYKE- 228
K +E+ ENE + T +E+EK + K + CL+ ++ + Y E
Sbjct: 607 KEYEELKEEKTLFSCWKSENEKLLT--QMESEKENLQSKINHLETCLKTQQIKSHEYNER 664
Query: 229 -DDMESVYEALQTEIEFLELTLAQKDLQ 255
+E E L EI L L K ++
Sbjct: 665 VRTLEMDRENLSVEIRNLHNVLDSKSVE 692
Score = 55.1 bits (131), Expect = 6e-08
Identities = 61/269 (22%), Positives = 116/269 (43%), Gaps = 46/269 (17%)
Query: 26 EVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITN 85
E++ E+ +K + EEL+ EK +L + LQLL + + Q E+T
Sbjct: 2620 ELQREMHEMAQKTAELQEELSGEKNRLAGE----------LQLLLEEIKSSKDQLKELTL 2669
Query: 86 HRNMLLQTFEAIKKQMIEEEDKFIKEITDF------------------NNDYEI------ 121
+ L ++ + + K +E+E K +EI ++ N YE+
Sbjct: 2670 ENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYR 2729
Query: 122 ---TKKRELLMKENVKIEI--SDLENQANMLKS------EMKSMEHDSSQ-LNELQKQKS 169
T K E L + ++I++ S E N LK+ E+K + D+ + +N+L+K+
Sbjct: 2730 EKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENE 2789
Query: 170 ELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKED 229
++ L + K E+E+ L+A + K DT+ L E++ KE
Sbjct: 2790 RAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKET 2849
Query: 230 DMESVYEALQTEIEFLELTLAQKDLQESK 258
E EA + ++ L ++ + L+++K
Sbjct: 2850 LEEKTKEADEYLDKYCSLLISHEKLEKAK 2878
Score = 46.2 bits (108), Expect = 3e-05
Identities = 68/290 (23%), Positives = 122/290 (42%), Gaps = 62/290 (21%)
Query: 25 REVRSEITRCREKIKKATEELNEEKIKLESKVQQFF-------------------EKSFF 65
RE+ E+T+ +K+ LN+EK+ L K + F EK
Sbjct: 967 REIE-ELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL 1025
Query: 66 LQLLKAHENALE--KQYSEITNHRNMLLQTF--------EAIKKQMIEEEDKFIKEITDF 115
LQ + NA E Q + +N L+ E K ++ + ++ F KE +F
Sbjct: 1026 LQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEF 1085
Query: 116 NNDYEITKKRE---LLMKENVKIEI-SDLENQANMLKSEMKSMEHD----SSQLNELQKQ 167
++R +L E V+ + S++ + N KSE ++ + + N++QK+
Sbjct: 1086 LTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKE 1145
Query: 168 KSELIQELFTLQRKLKV---FEDEENESI-CTTKYLEAEKIKISEKPQNDTECLRL---- 219
++L+QE L + +K ++ E+E I + K E+E+ + + KPQ D E +
Sbjct: 1146 VNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDS 1205
Query: 220 -------------KKELELYKEDDMESVYEALQTEIEFLELTLAQKDLQE 256
KEL+L + E E LQ E++ + L +LQ+
Sbjct: 1206 YNAQLVQLEAMLRNKELKL---QESEKEKECLQHELQTIRGDLETSNLQD 1252
Score = 43.9 bits (102), Expect = 1e-04
Identities = 66/273 (24%), Positives = 121/273 (44%), Gaps = 32/273 (11%)
Query: 3 LESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEK 62
L+++ Q + +++ AEE + + + +EKI + L EK+KL + ++
Sbjct: 509 LKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKL-AVADLEKQR 567
Query: 63 SFFLQLLKAHENALEK---QYSEITNHRNMLLQTFEAIKKQMIE-EEDKFIKEITDFNND 118
LLK E+ +E+ + S+ LL E KK+ E +E+K + N+
Sbjct: 568 DCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENE 627
Query: 119 YEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTL 178
+T+ KEN++ +I+ LE LK++ + ++ L+ + L E+ L
Sbjct: 628 KLLTQMES--EKENLQSKINHLE---TCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNL 682
Query: 179 QRKLKVFEDEENESICTTK--YLE-AEKIKIS-EKPQNDTE--CLR----------LKKE 222
L D ++ + T K Y+E +K + S +K Q + E CL+ L+ +
Sbjct: 683 HNVL----DSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHK 738
Query: 223 LELYKED--DMESVYEALQTEIEFLELTLAQKD 253
L+L + D + Y+ L E E L L KD
Sbjct: 739 LQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKD 771
Score = 42.4 bits (98), Expect = 4e-04
Identities = 70/308 (22%), Positives = 118/308 (38%), Gaps = 80/308 (25%)
Query: 26 EVRSEITRCREKIKKATEELN-------------EEKIKLESK----------------- 55
+ ++ T +K+KK TE+L+ E+KIK + K
Sbjct: 352 QASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLD 411
Query: 56 ---VQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKF---- 108
+Q + LQ K N L+ + ++T+ + L E K+++ E F
Sbjct: 412 QECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQ 471
Query: 109 IKEITDFNNDYEITKKRELLMK---ENVKIEISDLE----------NQANMLKSEMKSME 155
IKE + E KK L+K E E+ LE NQ+ EMK+
Sbjct: 472 IKE-NELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKN 530
Query: 156 -HDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKISE------ 208
+ L +LQ++ ++ L TL++ D E + C+ L+ + I +
Sbjct: 531 TSQETMLRDLQEKINQQENSL-TLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLS 589
Query: 209 KPQNDTECL-----RLKKELELYKED----------------DMESVYEALQTEIEFLEL 247
K + +++ L KKE E KE+ MES E LQ++I LE
Sbjct: 590 KTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLET 649
Query: 248 TLAQKDLQ 255
L + ++
Sbjct: 650 CLKTQQIK 657
Score = 41.2 bits (95), Expect = 0.001
Identities = 58/276 (21%), Positives = 117/276 (42%), Gaps = 34/276 (12%)
Query: 13 TEHQAEESRRLMREVRSEITRCREKIKKATEELNE---EKIKLESKVQ------QFFEKS 63
T+ + + RR + ++R I +K E+L E E L+ KV+ Q E++
Sbjct: 2110 TQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEEN 2169
Query: 64 FFLQLL-----KAHENALEKQYSEITNHRNM-------LLQTFEAIKKQMIEEEDKFI-- 109
L +L KA L+ Q E+ + L E + KQ+ E++ +
Sbjct: 2170 QELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSEL 2229
Query: 110 -KEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQK 168
K ++ F + E ++ E+ +KE K + L+NQ L + ++ D + ++
Sbjct: 2230 DKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSL 2289
Query: 169 SELIQELFTLQRKLKV----FEDEENESICTTKYLE-----AEKIK-ISEKPQNDTECLR 218
I+E L+ ++ E +E + +C + L+ A+ +K E + + E R
Sbjct: 2290 DPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIAR 2349
Query: 219 LKKELELYKEDDMESVYEALQTEIEFLELTLAQKDL 254
+E + ++ + E L+ +IE + +L +L
Sbjct: 2350 TNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLEL 2385
Score = 38.9 bits (89), Expect = 0.004
Identities = 60/289 (20%), Positives = 137/289 (47%), Gaps = 45/289 (15%)
Query: 11 IFTEHQAEESRRLMREVR--SEITRCREKIKKATEELNEEKIKLESKVQQFF-EKSFFLQ 67
+ E + +S+ ++EV+ ++I C E ++K EL +E L K++ F + LQ
Sbjct: 1800 LLNEMKELDSKLHLQEVQLMTKIEACIE-LEKIVGELKKENSDLSEKLEYFSCDHQELLQ 1858
Query: 68 LLKAHE--NALEKQYSEITNHRNM---LLQTFEAIKKQMIEEEDKFIK----------EI 112
++ E N+ + +++ ++ ++ + + ++ K++ ++ E++ + E
Sbjct: 1859 RVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEA 1918
Query: 113 TDFNNDYEITKKRELLMKEN----------VKIEISDLENQANMLKSEMKSMEHDSSQLN 162
D E+ + +L ++++ ++ E+S + ++ N L+ E+ +M ++ L+
Sbjct: 1919 LYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALD 1978
Query: 163 ELQKQKSELIQELFTLQRK----LKVFEDEENESICTTKYLEA-------EKIKISEKPQ 211
+L ++ E QEL + Q + ++V E E E + L + +K + EK Q
Sbjct: 1979 QLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQ 2038
Query: 212 N---DTECLRLKK-ELELYKEDDMESVYEALQTEIEFLELTLAQKDLQE 256
+ D++ L L K ELE + + E L E E L+ L++ D ++
Sbjct: 2039 SLEKDSQALSLTKCELE-NQIAQLNKEKELLVKESESLQARLSESDYEK 2086
Score = 38.1 bits (87), Expect = 0.008
Identities = 46/241 (19%), Positives = 95/241 (39%), Gaps = 31/241 (12%)
Query: 1 MSLESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFF 60
++LE L + E Q + S+ L+++ I + +K+ K +E LE K +++
Sbjct: 551 LTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYE 610
Query: 61 E----KSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIE------------- 103
E K+ F +E L + SE N ++ + +K Q I+
Sbjct: 611 ELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEM 670
Query: 104 EEDKFIKEITDFNN-----DYEITKKRELLMKENVKIEISDLENQ---------ANMLKS 149
+ + EI + +N E+ ++ M+ K E SD ++Q + L
Sbjct: 671 DRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTG 730
Query: 150 EMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKISEK 209
+++ +EH L+ K Q+L L+ ++ S+ T + + + ++
Sbjct: 731 QVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQ 790
Query: 210 P 210
P
Sbjct: 791 P 791
Score = 38.1 bits (87), Expect = 0.008
Identities = 54/270 (20%), Positives = 112/270 (41%), Gaps = 44/270 (16%)
Query: 6 LFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFF 65
+ Q + +EH A+ + + + E+ R + A E K ++E+ + +
Sbjct: 2320 VLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQS 2379
Query: 66 LQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYE-ITKK 124
L+ L+ + + +TN +++E + I E+ N+ +E I ++
Sbjct: 2380 LRGLELDVVTIRSEKENLTNE---------------LQKEQERISELEIINSSFENILQE 2424
Query: 125 RE---LLMKENVKIEISDLENQANMLKSEMKSMEHD-----------SSQLNELQKQKSE 170
+E + MKE + L+ Q L + ++ +D SSQ+ L+ +K++
Sbjct: 2425 KEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQ 2484
Query: 171 LIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELE------ 224
L+Q L + V + N I + +E K K+ +K D E RLK +++
Sbjct: 2485 LLQGLDEAKNNYIVLQSSVNGLI---QEVEDGKQKLEKK---DEEISRLKNQIQDQEQLV 2538
Query: 225 --LYKEDDMESVYEALQTEIEFLELTLAQK 252
L + + +++ E+ L + L QK
Sbjct: 2539 SKLSQVEGEHQLWKEQNLELRNLTVELEQK 2568
Score = 31.2 bits (69), Expect = 0.93
Identities = 40/176 (22%), Positives = 76/176 (43%), Gaps = 16/176 (9%)
Query: 67 QLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRE 126
+L K E ++Y +T + + A +K M EE K + E+ N+D +
Sbjct: 1302 ELEKICEILQAEKYELVTELNDSRSECITATRK-MAEEVGKLLNEVKILNDDSGLLHGE- 1359
Query: 127 LLMKENVKIEISDLENQANMLK----SEMKSMEHDSSQLNELQKQKSELIQELFTLQRKL 182
L+++ E + N+ + + E S EH + E+Q +EL ++ +LQ +
Sbjct: 1360 -LVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEH 1418
Query: 183 KVFEDEE-------NESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDM 231
K+ D+ +E L+AE + +S +N L KE++L E+ +
Sbjct: 1419 KILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQG--DLVKEMQLGLEEGL 1472
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 55.1 bits (131), Expect = 6e-08
Identities = 67/282 (23%), Positives = 123/282 (43%), Gaps = 59/282 (20%)
Query: 19 ESRRLMREV----RSEITRCREKIKKAT---EELNEEKIKLESKVQQFFEKSFFLQLLKA 71
E++R M E EI + R +IK+ T EEL E+K K E + EK+ L +
Sbjct: 368 ETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKA--LSTAQK 425
Query: 72 HENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDF---------------- 115
E A K +E+ + +T E + + +E + +E+ D
Sbjct: 426 TEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLH 485
Query: 116 -----NNDYEITKK---RELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQ 167
+ E+TKK RE +E +K+ + ++Q+ LK + + +S L EL+ Q
Sbjct: 486 EKELARKEQELTKKLQTREREFQEQMKVALE--KSQSEYLKISQEKEQQESLALEELELQ 543
Query: 168 KSELIQE----LFTLQRKLKVF---------------EDEENESICTTKYLEAEKIKISE 208
K ++ E L LQ++ + + ++ +N+S +LEAEK K ++
Sbjct: 544 KKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNK 603
Query: 209 K-----PQNDTECLRLKKELELYKEDDMESVYEALQTEIEFL 245
+ ++ TE LK + + + ++ + + QTE+E L
Sbjct: 604 EITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL 645
Score = 49.3 bits (116), Expect = 3e-06
Identities = 64/278 (23%), Positives = 122/278 (43%), Gaps = 35/278 (12%)
Query: 2 SLESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKA----TEELNEEKIKLESKVQ 57
+LE++F + T + E + +++ + E+ C + K+ EEL + KL++ +Q
Sbjct: 1830 NLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQA-LQ 1888
Query: 58 QFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMI-------EEEDKFIK 110
Q ++ +LL+ EN EK S + + LL EA + E+ K K
Sbjct: 1889 QMDGRNKPTELLE--ENTEEKSKSHLVQPK--LLSNMEAQHNDLEFKLAGAEREKQKLGK 1944
Query: 111 EITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSE 170
EI D + +K E +K E + + E ++H+S+ +++ ++
Sbjct: 1945 EIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQ 2004
Query: 171 LIQELFTLQRKLKVFEDEENESICTTKYLEAEKI------------KISEKPQNDTECLR 218
L Q+ L+ +K E+I + +EAE + KI+EK + +
Sbjct: 2005 LAQKEQELEMTIK-------ETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAK 2057
Query: 219 LKKELELYKEDDMESVYEALQTEIEFLELTLAQKDLQE 256
+E+ +E++M + LQT++E L+ QK QE
Sbjct: 2058 RYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQE 2095
Score = 48.9 bits (115), Expect = 4e-06
Identities = 47/223 (21%), Positives = 105/223 (47%), Gaps = 11/223 (4%)
Query: 18 EESRRLMREVRSEITRCREKIKKATEELNEEK-IKLESKVQQFFEKSFF-LQLLKAHENA 75
E+ + L ++ ++E+ + REK ++ E L ++K I ++ +++ EK+ L + + +
Sbjct: 629 EKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELES 688
Query: 76 LEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYE-----ITKKRELLMK 130
L + SE+ R+ L + +K Q + + + ++ + N ++ I K+ E+ ++
Sbjct: 689 LSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQ 748
Query: 131 ENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEEN 190
K + +LK K ++ + + L+ EL KL VF+ ++
Sbjct: 749 RTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQS 808
Query: 191 ESICTTKYLEAEKIKISEKPQN-DTECLRLKK---ELELYKED 229
+ TK E + ++ +K + +TE + L K E+E K+D
Sbjct: 809 ATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKD 851
Score = 46.2 bits (108), Expect = 3e-05
Identities = 44/182 (24%), Positives = 90/182 (49%), Gaps = 13/182 (7%)
Query: 24 MREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEI 83
+R +R E + E +KK ++ EEKIK E + + S QL++ L ++ E+
Sbjct: 1953 LRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL 2012
Query: 84 TNHRNMLLQTFEAIKKQMI----EEEDKFIKEITDFNNDYEITKKR--ELL--MKENVKI 135
+ + ++ +++ EE ++ +K+I + ++D + T KR E+L +E +
Sbjct: 2013 EMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA 2072
Query: 136 EISDLENQANML-KSEMKSMEHDSSQLNE---LQKQKSELIQELFTLQRKLKVFEDEENE 191
++ DL+ Q L K + +E + + N+ + + +++L Q+ TL K+ E E E
Sbjct: 2073 KVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKT-TLISDSKLKEQEFRE 2131
Query: 192 SI 193
I
Sbjct: 2132 QI 2133
Score = 45.8 bits (107), Expect = 4e-05
Identities = 59/268 (22%), Positives = 112/268 (41%), Gaps = 42/268 (15%)
Query: 14 EHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQF------FEKSFFLQ 67
+ A E + +++ E++ + EEL E+K+++ S +Q + S L
Sbjct: 1331 QQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLS 1390
Query: 68 LLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKK--- 124
+A ++L KQY E +Q + +E+ ++++ D++N + KK
Sbjct: 1391 EKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQ 1450
Query: 125 ----------RELLMKENVKI-EISDLENQANMLKSEMK-----------SMEHDSSQLN 162
+EL ++ +K E + + Q N+LK E+ ME D S
Sbjct: 1451 SRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKS--- 1507
Query: 163 ELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKISEK---PQNDTECLRL 219
+++K++S L EL + ++ ED T K +E E + K Q D E L
Sbjct: 1508 KMEKKESNLETELKSQTARIMELEDH-----ITQKTIEIESLNEVLKNYNQQKDIEHKEL 1562
Query: 220 KKELELYKEDDMESVYEALQTEIEFLEL 247
++L+ ++E E + E + L L
Sbjct: 1563 VQKLQHFQELGEEKDNRVKEAEEKILTL 1590
Score = 45.1 bits (105), Expect = 6e-05
Identities = 53/276 (19%), Positives = 122/276 (44%), Gaps = 32/276 (11%)
Query: 9 HIIFTEHQAE--ESRRLMREVRSEITRCREKIKKAT--------EELNEEKIKLESKVQQ 58
HI+ E++ + + M +V+ + +E +KK +EL ++L K +Q
Sbjct: 939 HILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQ 998
Query: 59 FFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEE-----EDKFIKEIT 113
F K L++ +A+ + S + ++ +++ + ++ + + E K ++
Sbjct: 999 FNAK--MLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAE 1056
Query: 114 DFNNDYEIT---KKRELL-MKENVKI---EISDLENQANMLKSEMKSMEHDSSQLNELQK 166
+ +EI K++E+ +K+ + + E ++ + LK E + ++L E K
Sbjct: 1057 ELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLK 1116
Query: 167 QKSELIQELFTLQRKLKV----FEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKE 222
QKS + L + KLK E + N+S+ +L+ + +++ + D ++ +
Sbjct: 1117 QKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKR--KVSEL 1174
Query: 223 LELYKEDDMESVYEALQTEIEFLELTLAQKDLQESK 258
K D E +++L++ E +L K L+ K
Sbjct: 1175 TSKLKTTDEE--FQSLKSSHEKSNKSLEDKSLEFKK 1208
Score = 43.9 bits (102), Expect = 1e-04
Identities = 53/235 (22%), Positives = 98/235 (41%), Gaps = 34/235 (14%)
Query: 30 EITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNM 89
EI E +K ++ + E +L K+Q F E L + +N +++ +I N
Sbjct: 1540 EIESLNEVLKNYNQQKDIEHKELVQKLQHFQE------LGEEKDNRVKEAEEKILTLENQ 1593
Query: 90 LLQT---FEAIKKQM------IEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDL 140
+ E KK++ ++ +++ +K + D K EL K KI
Sbjct: 1594 VYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKK 1653
Query: 141 ENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTK--- 197
+ + M + E + + S L+EL + E +E+ L+ KLK E ++E++ +
Sbjct: 1654 QLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAK 1713
Query: 198 ----YLEAEKI------------KISEKPQNDTECLRLKKELELYKEDDMESVYE 236
Y E E+ KIS +N TE +L + + KE+ + S +E
Sbjct: 1714 NVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFE 1768
Score = 43.1 bits (100), Expect = 2e-04
Identities = 59/251 (23%), Positives = 112/251 (44%), Gaps = 31/251 (12%)
Query: 18 EESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENAL- 76
+E + ++E ++ + IK++ EL + KL+ V Q ++ + Q KA+E L
Sbjct: 766 KERDKHLKEHQAHVENLEADIKRSEGELQQASAKLD--VFQSYQSATHEQT-KAYEEQLA 822
Query: 77 --EKQYSEITNHRNMLLQTF---EAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKE 131
+++ ++ R +L + EA KK + E D ++ D E K+ M++
Sbjct: 823 QLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLE---KQNSEMEQ 879
Query: 132 NVKI-------EISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKV 184
VK ++ D + K + E+ Q+ E QK++ E++ + + +
Sbjct: 880 KVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIH 939
Query: 185 FEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEIEF 244
+EE E+ + + EK+K K +T LKK+L D E+ L+ E+E
Sbjct: 940 ILNEEYETKFKNQEKKMEKVKQKAKEMQET----LKKKLL-----DQEA---KLKKELEN 987
Query: 245 LELTLAQKDLQ 255
L L+QK+ Q
Sbjct: 988 TALELSQKEKQ 998
Score = 41.6 bits (96), Expect = 7e-04
Identities = 51/244 (20%), Positives = 104/244 (42%), Gaps = 28/244 (11%)
Query: 5 SLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSF 64
++ I +H+ + + + ++ ++++ TEE N I + Q EK
Sbjct: 1245 AILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKEN 1304
Query: 65 FLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFI----KEITDFNNDYE 120
++ +KA +L + LQ ++Q E++ I KE+++ N
Sbjct: 1305 QIKSMKADIESLVTE--------KEALQKEGGNQQQAASEKESCITQLKKELSENINAVT 1356
Query: 121 ITKKRELLMKENVKIEISDLENQANMLKSEMK---SMEHDSSQLNELQKQ----KSELIQ 173
+ K+ +KE K+EIS L Q L +++ S+ + ++ L+KQ K EL+
Sbjct: 1357 LMKEE---LKEK-KVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLD 1412
Query: 174 ELFTLQRKLKVFEDEENESI-----CTTKYLEAEKIKISEKPQNDTECLRLKKELELYKE 228
++ L K+ E+ ++ + K+ E +K S Q+ L+ +LEL +
Sbjct: 1413 QVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSK 1472
Query: 229 DDME 232
+ E
Sbjct: 1473 EAYE 1476
Score = 37.7 bits (86), Expect = 0.010
Identities = 50/244 (20%), Positives = 113/244 (46%), Gaps = 13/244 (5%)
Query: 14 EHQAEESRRLMREVRSEITRCREKIKKATEEL----NEEKIKLESKVQQFFEK-SFFLQL 68
+ +AE R + E+ S + + ++ K +++L EK K ++ EK L+
Sbjct: 559 QQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELES 618
Query: 69 LKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITD-FNNDYEITKKREL 127
LK ++AL + ++ + E ++++ +E++ +K+ F E ++ L
Sbjct: 619 LKHQQDALWTEKLQVLKQQYQT--EMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTL 676
Query: 128 LMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFED 187
E + ++ ++LE+ ++ L +K+ +L+ L+ Q ++ QEL + K
Sbjct: 677 ---EKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQ 733
Query: 188 EENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEIEFLEL 247
++ +SI + ++ + + K Q + L LK+ + KE ++ E L+ +I+ E
Sbjct: 734 QQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEH--QAHVENLEADIKRSEG 791
Query: 248 TLAQ 251
L Q
Sbjct: 792 ELQQ 795
Score = 36.2 bits (82), Expect = 0.029
Identities = 40/194 (20%), Positives = 91/194 (46%), Gaps = 17/194 (8%)
Query: 62 KSFFLQLLKAHENALEK---QYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNND 118
K +Q L+ E +L +YSE+ ML + + ++ + + +DK ++ I + +
Sbjct: 136 KEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREE 195
Query: 119 YEITK--KRELLMKENVKIE-----ISDLENQANMLKSEMKSMEHDSSQLNELQKQKSEL 171
++ + K+ L + + +E IS L+ Q ++LK +++ + L L + + +
Sbjct: 196 LQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQ- 254
Query: 172 IQELFTLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDD- 230
E+FT + + + E + K LE + ++ + + R K+ ++ +KE
Sbjct: 255 -AEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVK---RQENLLKRCKETIQSHKEQCT 310
Query: 231 -MESVYEALQTEIE 243
+ S EALQ +++
Sbjct: 311 LLTSEKEALQEQLD 324
>gi|170784854 PTPRF interacting protein, binding protein 2 (liprin
beta 2) [Homo sapiens]
Length = 876
Score = 54.3 bits (129), Expect = 1e-07
Identities = 58/245 (23%), Positives = 116/245 (47%), Gaps = 31/245 (12%)
Query: 36 EKIKKATE--ELNEEKIKLESKV--------QQFFEKSFFLQLLKAHENALEKQYSEIT- 84
E ++ A E EL +E+ L S++ +++FE+S L + H A + Y E
Sbjct: 55 EDLRLALEMLELPQERAALLSQIPGPTAAYIKEWFEES--LSQVNHHSAASNETYQERLA 112
Query: 85 ----NHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITK-------KRELLMKENV 133
+ +++LQ ++ +E + + I+++ +++ ++ELL + ++
Sbjct: 113 RLEGDKESLILQV--SVLTDQVEAQGEKIRDLEVCLEGHQVKLNAAEEMLQQELLSRTSL 170
Query: 134 KIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESI 193
+ + DL + + LK ++ ME + + E Q++ EL+QEL L+ K++ E+E N+
Sbjct: 171 ETQKLDLMTEVSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIKVEELENERNQYE 230
Query: 194 CTTKYLEAEKIKISEK-PQNDTECLRLKKELE----LYKEDDMESVYEALQTEIEFLELT 248
K +AE ++ E+ D E RL +L L+ E E E + ++ L
Sbjct: 231 WKLKATKAEVAQLQEQVALKDAEIERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLL 290
Query: 249 LAQKD 253
LA +D
Sbjct: 291 LANED 295
Score = 33.9 bits (76), Expect = 0.14
Identities = 28/126 (22%), Positives = 59/126 (46%), Gaps = 12/126 (9%)
Query: 14 EHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHE 73
+ + EE +R E+ E+ + K+++ E N+ + KL++ + + + L A
Sbjct: 195 QREQEEKQRKAEELLQELRHLKIKVEELENERNQYEWKLKATKAEVAQLQEQVALKDAEI 254
Query: 74 NALEKQ-------YSEITNHRNMLLQTFEAIKKQMI---EEEDKFIKEITDFNNDYEITK 123
L Q +SE R+ +Q + + ++ E++D+ I+E+T N Y K
Sbjct: 255 ERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLLLANEDKDRRIEELTGLLNQYR--K 312
Query: 124 KRELLM 129
+E++M
Sbjct: 313 VKEIVM 318
>gi|190341068 forkhead-associated (FHA) phosphopeptide binding
domain 1 [Homo sapiens]
Length = 1412
Score = 54.3 bits (129), Expect = 1e-07
Identities = 60/238 (25%), Positives = 102/238 (42%), Gaps = 34/238 (14%)
Query: 18 EESRRLMREVRSEITRCREKIKKAT--------EELNEEKIKLESKVQQFFEKSFFLQLL 69
EE R+ M+E+ S + + ++ + K+ E L EE+ +++ ++ + L+
Sbjct: 706 EEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLESS 765
Query: 70 KAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLM 129
AHE K+ E E K Q +E KEI++ N YE K +E +
Sbjct: 766 IAHEKRKAKEALE-----------SEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAME 814
Query: 130 KENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEE 189
KE K++ DLEN+ K E++ E LN +++E +K K E +
Sbjct: 815 KEKKKVQ--DLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEE----TQKTKATESLK 868
Query: 190 NESIC-----TTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEI 242
ES+ T LE K K+ E L L++++ +D+ ES + EI
Sbjct: 869 AESLALKLNETLAELETTKTKMIMV----EERLILQQKMVKALQDEQESQRHGFEEEI 922
Score = 46.6 bits (109), Expect = 2e-05
Identities = 56/241 (23%), Positives = 116/241 (48%), Gaps = 42/241 (17%)
Query: 23 LMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFE----KSFFLQLLKAHENALEK 78
++ +++E+ +K+ + T EK ++ K Q E K +Q LK+ +AL+K
Sbjct: 253 IIANLQNEVAELSQKVSETTTSRQNEK-EISQKCQVLDEDIDAKQKEIQSLKSQISALQK 311
Query: 79 QYSEITNHRNMLLQTFEAIKKQM--IEEEDKFIKEITDFNNDYEITKKRELLMKEN---- 132
YS++ L QT ++ ++ E + +K + + ++++L K+
Sbjct: 312 GYSKV------LCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQ 365
Query: 133 VKIEISDLENQ--------------ANMLKSEMKSMEHDSSQLNELQKQKSELIQ-ELFT 177
+K E+S L++Q ++LK E+K E +L E Q+++ +L + ++
Sbjct: 366 LKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELK-QEDAHRELREAQEKELKLCKTQIQD 424
Query: 178 LQRKLKVFEDEENESICTTKYLEA----EKIKISEKPQNDTECLRLKKELELYKEDDMES 233
+++++K E +S CT + + + EK K+ EK Q D+ +K L+L + + ES
Sbjct: 425 MEKEMKKLRAELRKS-CTEQSVISRTLREKSKVEEKLQEDSR----RKLLQLQEMGNRES 479
Query: 234 V 234
V
Sbjct: 480 V 480
Score = 38.5 bits (88), Expect = 0.006
Identities = 39/191 (20%), Positives = 93/191 (48%), Gaps = 18/191 (9%)
Query: 3 LESLFQHIIFTEHQAEES-RRLMREVRSEITRCRE--------KIKKATEELNEEKIKLE 53
LES H +A ES +R ++++ + +T+ +E + +KA E + +EK K++
Sbjct: 762 LESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQ 821
Query: 54 SKVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEIT 113
+ ++ L+L + E+ L + S+ M+ +T + + ++ E +K +
Sbjct: 822 DLENRLTKQKEELELKEQKEDVLNNKLSDAL---AMVEETQKTKATESLKAESLALK-LN 877
Query: 114 DFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHD-SSQLNELQKQKSELI 172
+ + E TK + ++++E + ++ + L+ E +S H ++ E ++Q +
Sbjct: 878 ETLAELETTKTKMIMVEERLILQ----QKMVKALQDEQESQRHGFEEEIMEYKEQIKQHA 933
Query: 173 QELFTLQRKLK 183
Q + +L+ KL+
Sbjct: 934 QTIVSLEEKLQ 944
Score = 37.0 bits (84), Expect = 0.017
Identities = 41/179 (22%), Positives = 80/179 (44%), Gaps = 10/179 (5%)
Query: 83 ITNHRNMLLQTFEAIKKQMIEEEDKFI--KEITDFNNDYEITKKRELLMKENVKIEISD- 139
IT RN +T E +K+M E E K+ + E + +E L +E +++ +
Sbjct: 694 ITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEE 753
Query: 140 -LENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKY 198
L Q +L+S + + + + E +K+K + ++ T Q+++ E N + K
Sbjct: 754 RLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEI----SESNIAYEKRKA 809
Query: 199 LEAEKIKISEKPQNDTECLRLKKELEL--YKEDDMESVYEALQTEIEFLELTLAQKDLQ 255
EA + + + + + K+ELEL KED + + +E + T A + L+
Sbjct: 810 KEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLK 868
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 53.9 bits (128), Expect = 1e-07
Identities = 61/271 (22%), Positives = 120/271 (44%), Gaps = 60/271 (22%)
Query: 13 TEHQAEESRRLMREVRSEITRC------REKIKKATEELNEEKIKLESKVQQFFEKSFFL 66
+EHQ E +L ++ + +C +E++++ +E NEE KLE +V++ E++ +
Sbjct: 2104 SEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE-LEQALLV 2162
Query: 67 Q------------------LLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKF 108
+ L+A +A++++ EITN L +Q EE +
Sbjct: 2163 EDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQL--------EQFREELENK 2214
Query: 109 IKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQ-------- 160
+E+ + EI KK + ++ E ++ L +K + S+Q
Sbjct: 2215 NEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGK 2274
Query: 161 ----LNELQKQKSELIQELFTLQRKLKVFED-----EENESICTTKYLEAEKIKISEKPQ 211
+ E + + +L +++ LQ++LK+ D E+NE I + LE + E
Sbjct: 2275 FAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELI---RDLETQ----IECLM 2327
Query: 212 NDTECLRLKKELELYKEDDMESVYEALQTEI 242
+D EC++ +E E+ + + V E LQ E+
Sbjct: 2328 SDQECVKRNREEEI---EQLNEVIEKLQQEL 2355
Score = 50.1 bits (118), Expect = 2e-06
Identities = 55/240 (22%), Positives = 107/240 (44%), Gaps = 19/240 (7%)
Query: 22 RLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYS 81
R ++E I R +++ A+ L E LE++ QQ E+ +LL + A++ +
Sbjct: 1936 RQIQEKTDIIDRLEQELLCASNRLQE----LEAEQQQIQEER---ELLSRQKEAMKAEAG 1988
Query: 82 EITNHRNMLLQTFEAIKKQMIEEE-------DKFIKEITDFNNDYEITKKRELLMKENVK 134
+ LLQ E + K+ +E + D K++ D E R + +++
Sbjct: 1989 PV---EQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKN 2045
Query: 135 IEISDLENQANMLKSEMKSMEHD-SSQLNELQKQKSELIQELFTLQRKLKVFEDEENESI 193
E+ DL Q L+ +++ M Q + + ++ QE+ L+++LKV + S
Sbjct: 2046 TELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISE 2105
Query: 194 CTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEIEFLELTLAQKD 253
T+ +E + EK +E L K++L+ ++ E + E L+ + LE L +D
Sbjct: 2106 HQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEI-EKLEFRVRELEQALLVED 2164
Score = 47.8 bits (112), Expect = 1e-05
Identities = 44/214 (20%), Positives = 90/214 (42%), Gaps = 10/214 (4%)
Query: 12 FTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKA 71
++E A++S + + SE+ + +I++ EL E ++ ++ LQ L+
Sbjct: 145 YSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEG---------LQQLQE 195
Query: 72 HENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKE 131
E A+ KQ I LQ K + + E + ++ ++ + E L
Sbjct: 196 FEAAI-KQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNS 254
Query: 132 NVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENE 191
+DL + + + +E L + QK+K + ++ LQ K+KV+E E+++
Sbjct: 255 THSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDK 314
Query: 192 SICTTKYLEAEKIKISEKPQNDTECLRLKKELEL 225
+ + E ++ + + N KK LEL
Sbjct: 315 KVENSNKEEIQEKETIIEELNTKIIEEEKKTLEL 348
Score = 45.8 bits (107), Expect = 4e-05
Identities = 73/323 (22%), Positives = 138/323 (42%), Gaps = 69/323 (21%)
Query: 1 MSLESLFQHI-----IFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESK 55
M E + QH+ + T H+ E L S IT ++IK +NE IKL+
Sbjct: 448 MKQELIRQHMAQMEEMKTRHKGEMENALRSY--SNITVNEDQIKLMNVAINELNIKLQDT 505
Query: 56 VQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKF------I 109
Q + L L+ + AL++Q ++ + + + ++ + E+E K +
Sbjct: 506 NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSL 565
Query: 110 KEITDFNNDY--EITKKRELLMKE-----NVKIEISDLENQAN-----MLKSEMKSMEHD 157
+ D + ++EL +K N KI++ LE + N M +S+ +E
Sbjct: 566 STVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERL 625
Query: 158 SSQL-----NELQKQKSEL-------IQEL-----FTLQRKLKVFEDEENESICTTKY-- 198
+QL EL K K +L I++L ++++ ++E ++ I T ++
Sbjct: 626 RTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEK 685
Query: 199 -----------LEAEKIK------ISEKPQNDT-ECLRLKKELELYKEDD-----MESVY 235
LE K+K ++ K + T + L+KE+E+ ++++ +E
Sbjct: 686 DNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEV 745
Query: 236 EALQTEIEFLELTLAQK--DLQE 256
+ LQ + E LE + +K DLQE
Sbjct: 746 QELQLKTELLEKQMKEKENDLQE 768
Score = 45.4 bits (106), Expect = 5e-05
Identities = 60/289 (20%), Positives = 134/289 (46%), Gaps = 47/289 (16%)
Query: 8 QHIIFTEHQAEESRRLMRE----VRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKS 63
Q + + Q +E R L+ +++E +++ + TE+L +EK++++ + ++ +
Sbjct: 1960 QELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKV--RD 2017
Query: 64 FFLQLLKAHENALEKQYS---EITNHRNM----LLQTFEAIKKQMIEEEDKFIKE-ITDF 115
+ +KA E +E+Q S E+ +N L Q +A++KQ +E+ KF+ E D
Sbjct: 2018 DLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQ-LEKMRKFLDEQAIDR 2076
Query: 116 NNDYEITKKRELLMKENVKI----------EISDLENQANMLKSEMKSMEHDSSQLNELQ 165
++ ++ ++ +++ +K+ + ++E AN LK + +LQ
Sbjct: 2077 EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQ 2136
Query: 166 KQKSELIQELFTLQRKLKVFED-------------EENESICTTKYLEAEKIKISEKPQN 212
+ E +E+ L+ +++ E E + L+AE+ I K
Sbjct: 2137 RDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK--- 2193
Query: 213 DTECLRLKKELELYKEDDMESVYEA-----LQTEIEFLELTLAQKDLQE 256
+ E L+++LE ++E ++E+ E +Q EI+ E T ++L++
Sbjct: 2194 EKEITNLEEQLEQFRE-ELENKNEEVQQLHMQLEIQKKESTTRLQELEQ 2241
Score = 44.7 bits (104), Expect = 8e-05
Identities = 62/257 (24%), Positives = 123/257 (47%), Gaps = 27/257 (10%)
Query: 8 QHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQ 67
QH++F + ++++E EI + E++ K ++L KI ++KV + EK+ ++
Sbjct: 2268 QHVLFGKFA-----QIIQEKEVEIDQLNEQVTKLQQQL---KITTDNKVIE--EKNELIR 2317
Query: 68 LLKAH-ENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRE 126
L+ E + Q N + Q E I+K +++E I + T N + ++++ +
Sbjct: 2318 DLETQIECLMSDQECVKRNREEEIEQLNEVIEK--LQQELANIGQKTSMNA-HSLSEEAD 2374
Query: 127 LLMKENVKIEISD---LENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKL- 182
L K + + I++ LE Q EM M++ L E + ++L QELF+L+R+
Sbjct: 2375 SL-KHQLDVVIAEKLALEQQVETANEEMTFMKN---VLKETNFKMNQLTQELFSLKRERE 2430
Query: 183 ---KVFEDEENESICTTKYLEAEKIKISEKPQNDT-ECLRLKKELELYKEDDMESVYEAL 238
K+ EN +L +K ++ D + L + + ++E+ S+ L
Sbjct: 2431 SVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIIN-L 2489
Query: 239 QTEIEFLELTLAQKDLQ 255
+T + LE T++ KDL+
Sbjct: 2490 ETRLLQLESTVSAKDLE 2506
Score = 43.5 bits (101), Expect = 2e-04
Identities = 52/225 (23%), Positives = 103/225 (45%), Gaps = 32/225 (14%)
Query: 14 EHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHE 73
E+ ++ + M E++ E++ +++ + E+L+ EK+ + KS Q E
Sbjct: 3115 EYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAEL------KSELAQTKLELE 3168
Query: 74 NALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKREL---LMK 130
L+ Q+ L+ EA + ++ ++ D+ + + E K REL L K
Sbjct: 3169 TTLKAQHKH--------LKELEAFRLEVKDKTDEV--HLLNDTLASEQKKSRELQWALEK 3218
Query: 131 ENVKIEISDLENQANM--LKSEMKSMEHDSSQLNELQKQKSELI---QELFTLQRKL--K 183
E K+ S+ ++ + LK ++S + + QLN L +Q+ +L+ Q+ QR L
Sbjct: 3219 EKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDA 3278
Query: 184 VFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKE 228
+E+ ++ LE+EK++I E L +E EL+ +
Sbjct: 3279 QLSEEQGRNLELQVLLESEKVRIREMSST------LDRERELHAQ 3317
Score = 38.9 bits (89), Expect = 0.004
Identities = 58/261 (22%), Positives = 115/261 (44%), Gaps = 44/261 (16%)
Query: 16 QAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFL----QLLKA 71
+ ++SR L + E + ++ EEL + K LES+ Q+ + + L QLL
Sbjct: 3205 EQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNE 3264
Query: 72 HENALEKQY----SEITNH--RNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKR 125
+ +E Q ++++ RN+ LQ ++E E I+E++ + ++R
Sbjct: 3265 SQQKIESQRMLYDAQLSEEQGRNLELQV-------LLESEKVRIREMSS-----TLDRER 3312
Query: 126 ELLMKENVKIEISDLENQA-------NMLKSEMKSMEHDSSQ----LNELQKQKSELIQE 174
EL + +++ SD Q+ ++LK K +E S+ LNE +K K + +Q
Sbjct: 3313 EL----HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT 3368
Query: 175 LFTLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRL---KKELELYKEDDM 231
+++ +V +++ T + E K + Q+ E L+ +K ++YK D
Sbjct: 3369 RQQMEKDRQV----HRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLE 3424
Query: 232 ESVYEALQTEIEFLELTLAQK 252
+ + E + EL +K
Sbjct: 3425 GQRLQGIMQEFQKQELEREEK 3445
Score = 36.6 bits (83), Expect = 0.022
Identities = 51/243 (20%), Positives = 108/243 (44%), Gaps = 19/243 (7%)
Query: 10 IIFTEHQAEESRR--LMREVRSEITRCREKIKKATEELNEEKIKLES---KVQQF-FEKS 63
I F + QA E+ R +++ + +++I ++L E+ LE K + F + S
Sbjct: 240 IQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQIS 299
Query: 64 FFLQLLKAHENALEKQYSEITNHRNMLLQTF-EAIKKQMIEEEDKFIKEITDFNNDYEIT 122
F + +K +E +K+ +T E + ++IEEE K + E+ D ++T
Sbjct: 300 FLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTL-ELKD-----KLT 353
Query: 123 KKRELL--MKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQR 180
+LL ++E + + +++N +K E+ + + Q +E KQ ++EL
Sbjct: 354 TADKLLGELQEQIVQKNQEIKN----MKLELTNSKQKERQSSEEIKQLMGTVEELQKRNH 409
Query: 181 KLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEALQT 240
K FE + + + + E+++ + +++K+EL ME + +
Sbjct: 410 KDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKG 469
Query: 241 EIE 243
E+E
Sbjct: 470 EME 472
Score = 35.4 bits (80), Expect = 0.050
Identities = 40/198 (20%), Positives = 88/198 (44%), Gaps = 20/198 (10%)
Query: 37 KIKKATEEL-NEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFE 95
K+K + L N + ++ ++ + ++ L+ + + LE++ E+ L+T E
Sbjct: 701 KLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQ------LKT-E 753
Query: 96 AIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSME 155
++KQM E+E+ ++ + I K + +++ +KI + + + +KS
Sbjct: 754 LLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKS 813
Query: 156 HDS---SQLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKISE---- 208
DS ++ L ++ +L Q+ L ++ E + N K E ++ E
Sbjct: 814 KDSVWEKEIEILIEENEDLKQQCIQLNEEI---EKQRNTFSFAEKNFEVNYQELQEEYAC 870
Query: 209 --KPQNDTECLRLKKELE 224
K ++D E + K+ELE
Sbjct: 871 LLKVKDDLEDSKNKQELE 888
>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
sapiens]
Length = 1591
Score = 53.5 bits (127), Expect = 2e-07
Identities = 60/265 (22%), Positives = 132/265 (49%), Gaps = 32/265 (12%)
Query: 9 HIIFTEHQAEESRRLMREVR---SEITRCREK----IKKATEELNEEKIKLESKVQQFFE 61
H + E +E+++++ +++ +EI + +EK +K +L++ + KLE ++
Sbjct: 1010 HRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEA 1069
Query: 62 KSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEI 121
++ +++L A +K+ +++L Q E ++ ++ K ++I D N +Y++
Sbjct: 1070 ETDEIKILLEESRAQQKE-----TLKSLLEQETENLRTEI----SKLNQKIQDNNENYQV 1120
Query: 122 --TKKRELLMKEN---VKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELF 176
+ R L+ E + IS E ++N+LK+E+ + +Q E++K E I EL
Sbjct: 1121 GLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQ 1180
Query: 177 T-LQRKLKVFEDEENESIC--TTKY------LEAEKIKISEKPQNDTECLRLKKELELYK 227
+ L +L E +++E I KY LE ++ K+ + D E +L ++L K
Sbjct: 1181 SKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDRE--QLIQKLNCEK 1238
Query: 228 EDDMESVYEALQTEIEFLELTLAQK 252
++ +++ + + E E +E L +K
Sbjct: 1239 DEAIQTALKEFKLEREVVEKELLEK 1263
Score = 43.1 bits (100), Expect = 2e-04
Identities = 48/237 (20%), Positives = 110/237 (46%), Gaps = 22/237 (9%)
Query: 17 AEESRRLMREVRS--EITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHEN 74
A E R ++ +V+ EIT + K+ NE + KL+ +++ E ++ LK
Sbjct: 841 AVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELV 900
Query: 75 ALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNND----YEITKKRELLMK 130
LE+ N ++ EA+ E++ K ++ ++ E+ + RE++++
Sbjct: 901 CLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLE 960
Query: 131 ENVKIEISDLENQANMLKSEMKSME-------HDSSQLNELQKQKSELIQELFTLQRKLK 183
+ K+ + + + + +L++E++S+E D+ Q+ +Q+ + + +L+ K
Sbjct: 961 DLKKLHVEN-DEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKK 1019
Query: 184 VFE------DEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESV 234
+ E + I K + +++K+ +DT C +L+ EL L KE + + +
Sbjct: 1020 ENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRC-KLEVELAL-KEAETDEI 1074
Score = 40.4 bits (93), Expect = 0.002
Identities = 43/191 (22%), Positives = 81/191 (42%), Gaps = 19/191 (9%)
Query: 4 ESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKS 63
E++ Q++ + S+ RE + C EK + L E K++ E ++ EK
Sbjct: 1206 EAIIQNLEKDRQKLVSSQEQDREQLIQKLNC-EKDEAIQTALKEFKLEREVVEKELLEKV 1264
Query: 64 FFLQLLKAHENALEK---QYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKE--------- 111
L+ A A++ S + LQ +A + +EE++K E
Sbjct: 1265 KHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSL 1324
Query: 112 ITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSEL 171
I + ++ RE + KEN+ ++SD LKS M+ E D + L + ++ L
Sbjct: 1325 IAEQQTNFNTVLTREKMRKENIINDLSD------KLKSTMQQQERDKDLIESLSEDRARL 1378
Query: 172 IQELFTLQRKL 182
++E L+ ++
Sbjct: 1379 LEEKKKLEEEV 1389
Score = 33.5 bits (75), Expect = 0.19
Identities = 48/201 (23%), Positives = 88/201 (43%), Gaps = 23/201 (11%)
Query: 77 EKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEI--TKKRELLMKENVK 134
EK E+ + +N + + K+ E E+K K + E+ K E + ++ K
Sbjct: 861 EKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEK 920
Query: 135 IEISDLENQANMLKSEMKSMEHDSS-QLNELQKQKSELIQELFTLQRKLKVFEDE----- 188
+ L+N+ + EM+++ H + ++ EL++ + ++++L +KL V DE
Sbjct: 921 EAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDL----KKLHVENDEKLQLL 976
Query: 189 --ENESICTTKYLEAE------KIKISEKPQND--TECLRLKKELELYKEDDMESVYEAL 238
E +S+ + E E I+ EK D LKKE + ES E +
Sbjct: 977 RAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEII 1036
Query: 239 Q-TEIEFLELTLAQKDLQESK 258
Q E + EL L DL +++
Sbjct: 1037 QEKEKQLQELKLKVSDLSDTR 1057
>gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo
sapiens]
Length = 1594
Score = 53.5 bits (127), Expect = 2e-07
Identities = 60/265 (22%), Positives = 132/265 (49%), Gaps = 32/265 (12%)
Query: 9 HIIFTEHQAEESRRLMREVR---SEITRCREK----IKKATEELNEEKIKLESKVQQFFE 61
H + E +E+++++ +++ +EI + +EK +K +L++ + KLE ++
Sbjct: 1010 HRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEA 1069
Query: 62 KSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEI 121
++ +++L A +K+ +++L Q E ++ ++ K ++I D N +Y++
Sbjct: 1070 ETDEIKILLEESRAQQKE-----TLKSLLEQETENLRTEI----SKLNQKIQDNNENYQV 1120
Query: 122 --TKKRELLMKEN---VKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELF 176
+ R L+ E + IS E ++N+LK+E+ + +Q E++K E I EL
Sbjct: 1121 GLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQ 1180
Query: 177 T-LQRKLKVFEDEENESIC--TTKY------LEAEKIKISEKPQNDTECLRLKKELELYK 227
+ L +L E +++E I KY LE ++ K+ + D E +L ++L K
Sbjct: 1181 SKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDRE--QLIQKLNCEK 1238
Query: 228 EDDMESVYEALQTEIEFLELTLAQK 252
++ +++ + + E E +E L +K
Sbjct: 1239 DEAIQTALKEFKLEREVVEKELLEK 1263
Score = 43.1 bits (100), Expect = 2e-04
Identities = 48/237 (20%), Positives = 110/237 (46%), Gaps = 22/237 (9%)
Query: 17 AEESRRLMREVRS--EITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHEN 74
A E R ++ +V+ EIT + K+ NE + KL+ +++ E ++ LK
Sbjct: 841 AVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELV 900
Query: 75 ALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNND----YEITKKRELLMK 130
LE+ N ++ EA+ E++ K ++ ++ E+ + RE++++
Sbjct: 901 CLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLE 960
Query: 131 ENVKIEISDLENQANMLKSEMKSME-------HDSSQLNELQKQKSELIQELFTLQRKLK 183
+ K+ + + + + +L++E++S+E D+ Q+ +Q+ + + +L+ K
Sbjct: 961 DLKKLHVEN-DEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKK 1019
Query: 184 VFE------DEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESV 234
+ E + I K + +++K+ +DT C +L+ EL L KE + + +
Sbjct: 1020 ENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRC-KLEVELAL-KEAETDEI 1074
Score = 40.4 bits (93), Expect = 0.002
Identities = 43/191 (22%), Positives = 81/191 (42%), Gaps = 19/191 (9%)
Query: 4 ESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKS 63
E++ Q++ + S+ RE + C EK + L E K++ E ++ EK
Sbjct: 1206 EAIIQNLEKDRQKLVSSQEQDREQLIQKLNC-EKDEAIQTALKEFKLEREVVEKELLEKV 1264
Query: 64 FFLQLLKAHENALEK---QYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKE--------- 111
L+ A A++ S + LQ +A + +EE++K E
Sbjct: 1265 KHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSL 1324
Query: 112 ITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSEL 171
I + ++ RE + KEN+ ++SD LKS M+ E D + L + ++ L
Sbjct: 1325 IAEQQTNFNTVLTREKMRKENIINDLSD------KLKSTMQQQERDKDLIESLSEDRARL 1378
Query: 172 IQELFTLQRKL 182
++E L+ ++
Sbjct: 1379 LEEKKKLEEEV 1389
Score = 33.5 bits (75), Expect = 0.19
Identities = 48/201 (23%), Positives = 88/201 (43%), Gaps = 23/201 (11%)
Query: 77 EKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEI--TKKRELLMKENVK 134
EK E+ + +N + + K+ E E+K K + E+ K E + ++ K
Sbjct: 861 EKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEK 920
Query: 135 IEISDLENQANMLKSEMKSMEHDSS-QLNELQKQKSELIQELFTLQRKLKVFEDE----- 188
+ L+N+ + EM+++ H + ++ EL++ + ++++L +KL V DE
Sbjct: 921 EAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDL----KKLHVENDEKLQLL 976
Query: 189 --ENESICTTKYLEAE------KIKISEKPQND--TECLRLKKELELYKEDDMESVYEAL 238
E +S+ + E E I+ EK D LKKE + ES E +
Sbjct: 977 RAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEII 1036
Query: 239 Q-TEIEFLELTLAQKDLQESK 258
Q E + EL L DL +++
Sbjct: 1037 QEKEKQLQELKLKVSDLSDTR 1057
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 53.5 bits (127), Expect = 2e-07
Identities = 59/252 (23%), Positives = 110/252 (43%), Gaps = 45/252 (17%)
Query: 17 AEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENAL 76
AEE+ ++ + ++ K+++ ++LN +K+ L + + ++ LQ + N+L
Sbjct: 1813 AEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQ---LQEKREAVNSL 1869
Query: 77 EKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIE 136
+++ + + +H N+ Q TK +++L+ E +++
Sbjct: 1870 QEELANVQDHLNLAKQDL------------------------LHTTKHQDVLLSEQTRLQ 1905
Query: 137 ISDLENQANMLKSEMKSMEHDSSQL----NELQKQKSELIQELFTLQRKLKVFEDEENES 192
D+ AN + K E QL NE+++ K +L+Q+ QR K E EE++
Sbjct: 1906 -KDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESK- 1963
Query: 193 ICTTKYLEAEKIKISEKP-QNDTECLRLKKELE--LYKEDDMESVYEALQTE---IEFLE 246
LE K+ + E+ Q + E K +L+ L K E LQ E E LE
Sbjct: 1964 ------LETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLE 2017
Query: 247 LTLAQKDLQESK 258
TL+Q Q S+
Sbjct: 2018 KTLSQTKRQLSE 2029
Score = 50.8 bits (120), Expect = 1e-06
Identities = 55/279 (19%), Positives = 124/279 (44%), Gaps = 39/279 (13%)
Query: 3 LESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEK------------- 49
+E + + ++ + E+ RL+ E SE++ +EK K A E+ + K
Sbjct: 1421 IECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEEL 1480
Query: 50 -----------IKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIK 98
+K + +++ + L+ K + + K+ ++I ++ Q K
Sbjct: 1481 ERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKK 1540
Query: 99 KQMIEEEDKFIK--EITDFNNDY--EITKKRELLMKENVKIEISDLENQANMLKSEMKSM 154
+++ EE K K E+ + N D+ ++ K+ E+L++ + E+ L++Q + EM +
Sbjct: 1541 EKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAK-RAELEKLKSQVTSQQQEMAVL 1599
Query: 155 EHD-SSQLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKIS-EKPQN 212
+ + EL + ++Q LQ L++ E E E + +++ ++S +K +
Sbjct: 1600 DRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGEL 1659
Query: 213 DTECLRLKKELELYKEDDMESVYEALQTEIEFLELTLAQ 251
+ + K +L L K++ ++ E E L++ L Q
Sbjct: 1660 NVQISERKTQLTLIKQE--------IEKEEENLQVVLRQ 1690
Score = 43.1 bits (100), Expect = 2e-04
Identities = 57/254 (22%), Positives = 112/254 (44%), Gaps = 28/254 (11%)
Query: 14 EHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHE 73
E + ++ + E+ EI + ++I +ATEE + LE +Q ++ +A +
Sbjct: 443 EKKISAAQTRLSELHDEIEKAEQQILRATEEFKQ----LEEAIQ-------LKKISEAGK 491
Query: 74 NALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFI---KEITDFNNDYEITKKRELLMK 130
+ L KQ S N L Q ++ QM +++ + KEI D + ++
Sbjct: 492 DLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDP-KH 550
Query: 131 ENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEEN 190
++K + S E Q +++ + + +E S+L+E+ + ++ +E+ L+ +L + N
Sbjct: 551 SHMKAQKSGKEQQLDIMNKQYQQLE---SRLDEILSRIAKETEEIKDLEEQLTEGQIAAN 607
Query: 191 ESICTTKYLEAEKIKISE--------KPQNDTECLRLKKELELYKEDDMESVYEALQTEI 242
E++ K LE + E Q EC +L+ E E + E E Q EI
Sbjct: 608 EAL--KKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEI 665
Query: 243 EFLELTLAQKDLQE 256
++ +K+L E
Sbjct: 666 VAMDAENMRKELAE 679
Score = 43.1 bits (100), Expect = 2e-04
Identities = 54/279 (19%), Positives = 131/279 (46%), Gaps = 23/279 (8%)
Query: 1 MSLESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFF 60
+ +E +H + E + + + RSE+ + +A EL+ K K ++ V++F
Sbjct: 1405 LEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFT 1464
Query: 61 EKSFFLQLLKAHENALEKQYSEITNH---RNMLLQTFEAIKKQMIE---EEDKFIKEITD 114
+ L ++ LE++ E + + L++ +A K + + ++++ +KEI
Sbjct: 1465 DAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINK 1524
Query: 115 F----NNDYE-ITKKRELLMKENVKIEISDLE-------NQANMLKSEMKSMEHDSSQLN 162
++D++ ++KK+E L +E K++ D+E + +LK ++ ++L
Sbjct: 1525 IVAAKDSDFQCLSKKKEKLTEELQKLQ-KDIEMAERNEDHHLQVLKESEVLLQAKRAELE 1583
Query: 163 ELQKQKSELIQELFTLQRKLKVFEDEEN---ESICTTKYLEAEKIKISEKPQNDTECLRL 219
+L+ Q + QE+ L R+L ++E + S+ K E +++ E + +C +
Sbjct: 1584 KLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTE-KCNHI 1642
Query: 220 KKELELYKEDDMESVYEALQTEIEFLELTLAQKDLQESK 258
++ L +E + +Q +LTL ++++++ +
Sbjct: 1643 REVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEE 1681
Score = 40.8 bits (94), Expect = 0.001
Identities = 56/276 (20%), Positives = 127/276 (46%), Gaps = 41/276 (14%)
Query: 3 LESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEK 62
L+ + Q ++F Q E + S++T +E+ + +EL ++K KL+ + +
Sbjct: 1941 LKLVQQEMMFQRLQKERESEESKLETSKVT-LKEQQHQLEKELTDQKSKLDQVLSKVLAA 1999
Query: 63 SFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFI---KEITDFNNDY 119
++ L+ E E ++ + L + ++Q++E+ + + KE D+
Sbjct: 2000 EERVRTLQEEERWCESLEKTLSQTKRQLSER----EQQLVEKSGELLALQKEADSMRADF 2055
Query: 120 EITKKRELL-----------MKENVKIEISDLE-------NQANMLKSEMKSME------ 155
+ + + L +KE +KI+ S LE + + ++ EM ++E
Sbjct: 2056 SLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDN 2115
Query: 156 HDSS-----QLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKISEKP 210
H+ + +LN++Q + +EL +++ Q+ L+ + E ++++ T K ++I+ S K
Sbjct: 2116 HERARRLMKELNQMQYEYTELKKQMAN-QKDLERRQMEISDAMRTLKSEVKDEIRTSLKN 2174
Query: 211 QNDTECLRLKKELE--LYKEDDMESVYEALQTEIEF 244
N L +LE L + +++E E+L+ + F
Sbjct: 2175 LNQF-LPELPADLEAILERNENLEGELESLKENLPF 2209
Score = 39.7 bits (91), Expect = 0.003
Identities = 40/177 (22%), Positives = 75/177 (42%), Gaps = 24/177 (13%)
Query: 26 EVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITN 85
EV + + R K+K T E+N I S V L L+KQ+SEI
Sbjct: 808 EVAARVDELRRKLKLGTGEMN---IHSPSDV------------LGKSLADLQKQFSEILA 852
Query: 86 HRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENV-----KIEISDL 140
+ ++++ EE +++ ++ +R L + N + I +
Sbjct: 853 RSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQM 912
Query: 141 ENQANMLKSEMKSMEH----DSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESI 193
EN+ + L+ +KSME QL E ++K ++ +L L++K K+ + + E +
Sbjct: 913 ENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQV 969
Score = 37.4 bits (85), Expect = 0.013
Identities = 38/214 (17%), Positives = 92/214 (42%), Gaps = 22/214 (10%)
Query: 45 LNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEE 104
L E +LE +Q K + ++A + EK+ E+ H N+ +++E
Sbjct: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEEL--HHNI---------DDLLQE 1369
Query: 105 EDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNEL 164
+ E+ + + + ++++ + NV+ +++LE + KS++H ++E+
Sbjct: 1370 KKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIE--------KSLKHHEDIVDEI 1421
Query: 165 QKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELE 224
+ + L++ L+ ++ + E+E CT E K + + L+ + + E
Sbjct: 1422 ECIEKTLLKRRSELREADRLLAEAESELSCTK---EKTKNAVEKFTDAKRSLLQTESDAE 1478
Query: 225 LYKEDDMESVYEALQTEIEFLELTLAQKDLQESK 258
+ E+ ++ + + L KDL++ K
Sbjct: 1479 ELERRAQETAVNLVKADQQLRSLQADAKDLEQHK 1512
Score = 36.2 bits (82), Expect = 0.029
Identities = 38/165 (23%), Positives = 74/165 (44%), Gaps = 10/165 (6%)
Query: 36 EKIKKATEELNEEKIKLESKVQQFFEKSFFLQL----LKAHENALEKQYSEITNHRNMLL 91
E + E + +E +LES +Q+ E + LQ L A+E LE + + N L
Sbjct: 664 EIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLK 723
Query: 92 QTFEAIKKQMIEEED----KFIKEITDFNNDYEITKKRELLMKENVKI--EISDLENQAN 145
+ E + + E+ + KE N + E +EN ++ ++ L++ N
Sbjct: 724 EELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNN 783
Query: 146 MLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEEN 190
+LK ++K ++ + + + + E+ + L+RKLK+ E N
Sbjct: 784 LLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMN 828
Score = 30.8 bits (68), Expect = 1.2
Identities = 27/124 (21%), Positives = 60/124 (48%), Gaps = 11/124 (8%)
Query: 95 EAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEIS---DLENQANMLKSEM 151
EA ++ +EE ++ +++ + E K ++ E +K + L+ +A + K
Sbjct: 262 EAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSC 321
Query: 152 KSMEHDSSQLNELQKQK----SELIQELFTLQRKLKVFE-DEENESICTTKYLEAEKIKI 206
+ ++ D + NEL KQK + Q+ + L+++L ++ D + E + Y +E +I
Sbjct: 322 EELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPL---NYYPSEYAEI 378
Query: 207 SEKP 210
+ P
Sbjct: 379 DKAP 382
Score = 30.8 bits (68), Expect = 1.2
Identities = 29/131 (22%), Positives = 64/131 (48%), Gaps = 5/131 (3%)
Query: 132 NVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENE 191
N++ E+S LE+ LKS+ + + + +K+ EL + L ++ K E E E
Sbjct: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEE 1379
Query: 192 SICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKE--DDMESVYEAL---QTEIEFLE 246
T + + +K I ++ L ++K L+ +++ D++E + + L ++E+ +
Sbjct: 1380 LHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREAD 1439
Query: 247 LTLAQKDLQES 257
LA+ + + S
Sbjct: 1440 RLLAEAESELS 1450
Score = 28.9 bits (63), Expect = 4.6
Identities = 29/128 (22%), Positives = 58/128 (45%), Gaps = 17/128 (13%)
Query: 40 KATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKK 99
++ E L + + + + Q+ FE+ F L+ ++ E LEK+ E ++ + E IK
Sbjct: 245 RSLESLEGQPVTTQDR-QEAFER-FSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKN 302
Query: 100 QMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSS 159
Q DK K + K+ +L K++ + SDL + +LK + +
Sbjct: 303 Q-----DKLNKSL----------KEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQ 347
Query: 160 QLNELQKQ 167
+ EL+++
Sbjct: 348 KQYELEQE 355
>gi|124249396 coiled-coil domain containing 30 [Homo sapiens]
Length = 783
Score = 53.1 bits (126), Expect = 2e-07
Identities = 55/267 (20%), Positives = 111/267 (41%), Gaps = 38/267 (14%)
Query: 19 ESRRLMREVRSEITRCREKIK-------------KATEELNEEKIKLESKVQQFFEKSFF 65
+S ++ + +E C++KIK K+ L E+ ++ +SKV EK
Sbjct: 299 DSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILD 358
Query: 66 LQLLKAH-------------ENALEKQYSEITNHRNMLLQTFEAIKK------QMIEEED 106
LQ H + LE++ E T + + Q ++ ++ Q ++E
Sbjct: 359 LQRKLEHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEEQQKRKLLYQNVDELH 418
Query: 107 KFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQK 166
+ ++ + D N E+T ++ + + + LEN+ +KS + S +L++LQ+
Sbjct: 419 RQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQ 478
Query: 167 QKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELY 226
+K L +E L + L V NE +K+K+ + T + L+ +
Sbjct: 479 EKEALREEYLRLLKLLNVHVRNYNEK------HHQQKVKLQKVKYRLTNEVELRDKRINQ 532
Query: 227 KEDDMESVYEALQTEIEFLELTLAQKD 253
ED++ + ++ E + AQ D
Sbjct: 533 FEDEIGILQHKIEKEKAIQDQITAQND 559
Score = 35.4 bits (80), Expect = 0.050
Identities = 57/275 (20%), Positives = 109/275 (39%), Gaps = 58/275 (21%)
Query: 18 EESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALE 77
EE + + EI R RE++ + L + + +S + + LK ++
Sbjct: 182 EEKEQQLTMKPEEIVRLREELSHINQSLLQSQSSGDSSDDSGAQHPSSGEKLKYNQQGEV 241
Query: 78 KQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEI 137
+Q + + +L + E E ++ + + ++ + LL +EN+KI+I
Sbjct: 242 QQLHQNLHRLQILCNS--------AENELRYER-----GQNLDLKQHNSLLQEENIKIKI 288
Query: 138 SDLENQANMLKS---------------------EMKSMEHDSS--QLNELQ----KQKSE 170
Q +L S E++ ++H S N LQ ++KS+
Sbjct: 289 ELKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKHTQSIKSQNNLQEKLVQEKSK 348
Query: 171 LI---QELFTLQRKLKVFEDEENESICTTKYLEAEK----IKISEKPQNDTECL------ 217
+ +++ LQRKL E +C T +EK KI E QN+ +
Sbjct: 349 VADAEEKILDLQRKL-----EHAHKVCLTDTCISEKQQLEEKIKEATQNEAKVKQQYQEE 403
Query: 218 RLKKELELYKEDDMESVYEALQTEIEFLELTLAQK 252
+ K++L D++ LQ + LE+T +Q+
Sbjct: 404 QQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQ 438
Score = 33.5 bits (75), Expect = 0.19
Identities = 41/210 (19%), Positives = 82/210 (39%), Gaps = 42/210 (20%)
Query: 29 SEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAH---------ENALE-- 77
SE + EKIK+AT+ NE K+K + + +Q K + + + H EN LE
Sbjct: 377 SEKQQLEEKIKEATQ--NEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMT 434
Query: 78 -----------------------------KQYSEITNHRNMLLQTFEAIKKQMIEEEDKF 108
K E++ + L Q EA++++ +
Sbjct: 435 CSQQQSRIQQQEALLKQLENEKRKYDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLL 494
Query: 109 IKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQK 168
+ ++N + K + +K + E+ + + N + E+ ++H + +Q Q
Sbjct: 495 NVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQI 554
Query: 169 SELIQELFTLQRKLKVFEDEENESICTTKY 198
+ L +RKL+ E+ + I + K+
Sbjct: 555 TAQNDTLLLEKRKLQEQVIEQEQLIHSNKW 584
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 53.1 bits (126), Expect = 2e-07
Identities = 69/260 (26%), Positives = 125/260 (48%), Gaps = 37/260 (14%)
Query: 13 TEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAH 72
TE EES++L++ ++SE+ EK+ T E +E KL+S+ ++ E S + LLK
Sbjct: 544 TEKLIEESKKLLK-LKSEM---EEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKR 599
Query: 73 ENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITK-KRELLMKE 131
+ +E+ EIT R+ ++ ED IKE+T EI + K+ L E
Sbjct: 600 LDGIEEVEREITRGRSRK-------GSELTCPEDNKIKELT-----LEIERLKKRLQQLE 647
Query: 132 NVKIEISDLENQANMLKSEMKSMEHD-----SSQLNELQKQ--------KSELIQELFTL 178
V+ ++ E++ + L+ + ++ E D S QL E++ Q K E++ + L
Sbjct: 648 VVEGDLMKTEDEYDQLEQKFRT-EQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAEL 706
Query: 179 QRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEAL 238
+ + ++ EE +S ++A K KI E + + +L+ + + ++ ME +
Sbjct: 707 RHRFRL---EEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNK 763
Query: 239 QTEIEFLELTLAQKDLQESK 258
E L LT K+L+ SK
Sbjct: 764 NMGQEVLNLT---KELELSK 780
Score = 47.0 bits (110), Expect = 2e-05
Identities = 69/271 (25%), Positives = 127/271 (46%), Gaps = 42/271 (15%)
Query: 1 MSLESLFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKL-------E 53
M ++ HI Q+++ + L +++R E EK+K T + E++ KL E
Sbjct: 249 MLVDERQMHIEQLGLQSQKVQDLTQKLREE----EEKLKAITSKSKEDRQKLLKLEVDFE 304
Query: 54 SKVQQFF----EKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKK---QMIEEED 106
K +F E + L ++H L + +T L +T + ++K ++ E D
Sbjct: 305 HKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRD 364
Query: 107 KFIKEITDFNN---DYEITKKRELLMKENVKIEISDLENQANMLKSEMKSMEHDSSQL-- 161
K K ++ + E +KR L M E EI+ E+Q L+ +++ EH S +L
Sbjct: 365 KIAKGECGNSSLMAEVENLRKRVLEM-EGKDEEITKTESQCRELRKKLQEEEHHSKELRL 423
Query: 162 --NELQKQKSEL--IQELFTLQRKLKVFEDEENESICTTKYLEAEKIK-ISEKPQNDTEC 216
+LQK+ SEL ++E F+ +++S CT +L EK K +++ N+ E
Sbjct: 424 EVEKLQKRMSELEKLEEAFS-----------KSKSECTQLHLNLEKEKNLTKDLLNELEV 472
Query: 217 LRLK-KELELYKEDDMESVYEALQTEIEFLE 246
++ + KELE E +E +L+ ++ L+
Sbjct: 473 VKSRVKELEC-SESRLEKAELSLKDDLTKLK 502
Score = 45.1 bits (105), Expect = 6e-05
Identities = 48/255 (18%), Positives = 106/255 (41%), Gaps = 23/255 (9%)
Query: 14 EHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHE 73
E + E ++L+ + ++ R ++ K +L +E +KL KSF L L+ +
Sbjct: 205 EQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKL---------KSFALMLVDERQ 255
Query: 74 NALEK------QYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKREL 127
+E+ + ++T + +AI + E+ K +K DF E R
Sbjct: 256 MHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDF----EHKASRFS 311
Query: 128 LMKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFED 187
E + ++++ E+ L+ ++ + +L E K + +EL L+ K+ E
Sbjct: 312 QEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGEC 371
Query: 188 EENESICTTKYLEAEKIKISEKPQN----DTECLRLKKELELYKEDDMESVYEALQTEIE 243
+ + + L +++ K + +++C L+K+L+ + E E + +
Sbjct: 372 GNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKR 431
Query: 244 FLELTLAQKDLQESK 258
EL ++ +SK
Sbjct: 432 MSELEKLEEAFSKSK 446
>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
Length = 971
Score = 52.8 bits (125), Expect = 3e-07
Identities = 60/278 (21%), Positives = 118/278 (42%), Gaps = 49/278 (17%)
Query: 8 QHIIFTEHQAEESR--RLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQF--FEKS 63
Q + + ++E+SR + ++ E R K + EE ++ ++LE KV + ++
Sbjct: 276 QEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQE 335
Query: 64 FFLQLLKAHENALEKQYSEITNHRNMLLQ--------TFEAIKKQMIEEEDKFIKEITDF 115
++ + LK ++ LE++ +++ + L+ EA+ I ++ K ++ +
Sbjct: 336 YYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQ 395
Query: 116 NNDYEIT---KKRELLMK-ENVKIEISDLENQANMLKSEMKSMEHDSSQ--------LNE 163
+N ++ K +L + EN+K + D N AN ++ M S Q +
Sbjct: 396 HNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIAS 455
Query: 164 LQKQKSELIQELFTLQRKLKVFED--------------EENESICTTKYLEAEKIKISEK 209
LQ + L EL + LK +D + E+I K E EK+K+ +
Sbjct: 456 LQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMK--EEEKLKVDKM 513
Query: 210 PQN---------DTECLRLKKELELYKEDDMESVYEAL 238
+ EC +L++EL L E+D +S L
Sbjct: 514 AHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQL 551
Score = 42.7 bits (99), Expect = 3e-04
Identities = 58/256 (22%), Positives = 117/256 (45%), Gaps = 44/256 (17%)
Query: 25 REVRSEITRCREKIKK------------------------ATEELNEEKIKLESKVQQFF 60
+EV SE+ RE++++ ++L EK ++ ++ Q
Sbjct: 239 KEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLE 298
Query: 61 EKSFFLQ-LLKAHENALEKQYSEITNHRNMLLQT-FEAIKKQMIEEEDKFIKEITDFNND 118
E+ FL+ ++ + ++Q E+ N +T E ++++ + + +E+T N
Sbjct: 299 EERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEA 358
Query: 119 YEITKKRELLMKENVKIEI--SDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELF 176
+ T + EL K ++ IE S+ L+ +++ +H+ +LN L++ K++L QEL
Sbjct: 359 HSKTLE-ELAWKHHMAIEAVHSNAIRDKKKLQMDLEE-QHNKDKLN-LEEDKNQLQQELE 415
Query: 177 TLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECL---------RLKKELELYK 227
L+ +V ED+ N + +L+ + ++ SE+ E L RL+ EL+L K
Sbjct: 416 NLK---EVLEDKLNTANQEIGHLQ-DMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTK 471
Query: 228 EDDMESVYEALQTEIE 243
+ E+ L E E
Sbjct: 472 DSLKETKDALLNVEGE 487
>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
Length = 1140
Score = 52.8 bits (125), Expect = 3e-07
Identities = 60/278 (21%), Positives = 118/278 (42%), Gaps = 49/278 (17%)
Query: 8 QHIIFTEHQAEESR--RLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQF--FEKS 63
Q + + ++E+SR + ++ E R K + EE ++ ++LE KV + ++
Sbjct: 396 QEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQE 455
Query: 64 FFLQLLKAHENALEKQYSEITNHRNMLLQ--------TFEAIKKQMIEEEDKFIKEITDF 115
++ + LK ++ LE++ +++ + L+ EA+ I ++ K ++ +
Sbjct: 456 YYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQ 515
Query: 116 NNDYEIT---KKRELLMK-ENVKIEISDLENQANMLKSEMKSMEHDSSQ--------LNE 163
+N ++ K +L + EN+K + D N AN ++ M S Q +
Sbjct: 516 HNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIAS 575
Query: 164 LQKQKSELIQELFTLQRKLKVFED--------------EENESICTTKYLEAEKIKISEK 209
LQ + L EL + LK +D + E+I K E EK+K+ +
Sbjct: 576 LQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMK--EEEKLKVDKM 633
Query: 210 PQN---------DTECLRLKKELELYKEDDMESVYEAL 238
+ EC +L++EL L E+D +S L
Sbjct: 634 AHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQL 671
Score = 42.7 bits (99), Expect = 3e-04
Identities = 58/256 (22%), Positives = 117/256 (45%), Gaps = 44/256 (17%)
Query: 25 REVRSEITRCREKIKK------------------------ATEELNEEKIKLESKVQQFF 60
+EV SE+ RE++++ ++L EK ++ ++ Q
Sbjct: 359 KEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLE 418
Query: 61 EKSFFLQ-LLKAHENALEKQYSEITNHRNMLLQT-FEAIKKQMIEEEDKFIKEITDFNND 118
E+ FL+ ++ + ++Q E+ N +T E ++++ + + +E+T N
Sbjct: 419 EERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEA 478
Query: 119 YEITKKRELLMKENVKIEI--SDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELF 176
+ T + EL K ++ IE S+ L+ +++ +H+ +LN L++ K++L QEL
Sbjct: 479 HSKTLE-ELAWKHHMAIEAVHSNAIRDKKKLQMDLEE-QHNKDKLN-LEEDKNQLQQELE 535
Query: 177 TLQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECL---------RLKKELELYK 227
L+ +V ED+ N + +L+ + ++ SE+ E L RL+ EL+L K
Sbjct: 536 NLK---EVLEDKLNTANQEIGHLQ-DMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTK 591
Query: 228 EDDMESVYEALQTEIE 243
+ E+ L E E
Sbjct: 592 DSLKETKDALLNVEGE 607
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 52.4 bits (124), Expect = 4e-07
Identities = 52/245 (21%), Positives = 118/245 (48%), Gaps = 14/245 (5%)
Query: 14 EHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKL---ESKVQQFFEKSFFLQLLK 70
E + E +RE ++ R EKI++ E++ E++ K+ E K+++ EK ++
Sbjct: 331 EEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEK------IQ 384
Query: 71 AHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMK 130
E + +Q +I + +K+M E+++K ++ + E ++ E +M+
Sbjct: 385 EQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQ 444
Query: 131 ENVKIEISDLENQANMLKSEMKSMEHD-SSQLNELQKQKSELIQELFTLQRKLKVFEDEE 189
+ + ++ ++E + + +M+ E Q ++Q+Q+ + ++ L+++ K++E EE
Sbjct: 445 DQEE-KLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEE 503
Query: 190 NESICTTKYLEAEK--IKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEIEFLEL 247
K E E+ + EK Q E +R ++E+ L+++++ E E+E
Sbjct: 504 KMWRQEEKMWEQEEKMQEQEEKMQRQEEKMR-EQEVRLWQQEEKMQEQEVRLQELEERLG 562
Query: 248 TLAQK 252
L QK
Sbjct: 563 KLGQK 567
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 52.4 bits (124), Expect = 4e-07
Identities = 52/245 (21%), Positives = 118/245 (48%), Gaps = 14/245 (5%)
Query: 14 EHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKL---ESKVQQFFEKSFFLQLLK 70
E + E +RE ++ R EKI++ E++ E++ K+ E K+++ EK ++
Sbjct: 331 EEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEK------IQ 384
Query: 71 AHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMK 130
E + +Q +I + +K+M E+++K ++ + E ++ E +M+
Sbjct: 385 EQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQ 444
Query: 131 ENVKIEISDLENQANMLKSEMKSMEHD-SSQLNELQKQKSELIQELFTLQRKLKVFEDEE 189
+ + ++ ++E + + +M+ E Q ++Q+Q+ + ++ L+++ K++E EE
Sbjct: 445 DQEE-KLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEE 503
Query: 190 NESICTTKYLEAEK--IKISEKPQNDTECLRLKKELELYKEDDMESVYEALQTEIEFLEL 247
K E E+ + EK Q E +R ++E+ L+++++ E E+E
Sbjct: 504 KMWRQEEKMWEQEEKMQEQEEKMQRQEEKMR-EQEVRLWQQEEKMQEQEVRLQELEERLG 562
Query: 248 TLAQK 252
L QK
Sbjct: 563 KLGQK 567
>gi|157785668 coiled-coil domain containing 39 [Homo sapiens]
Length = 941
Score = 52.4 bits (124), Expect = 4e-07
Identities = 55/261 (21%), Positives = 125/261 (47%), Gaps = 19/261 (7%)
Query: 13 TEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAH 72
T +Q E+ R+ +++ E+ + + + + +L + + + E++ LQ K H
Sbjct: 295 TAYQDHETSRI--QLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNH 352
Query: 73 ENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYE--ITKKRELLMK 130
++ + EIT + M ++ + M++EE+K +KE+ N + + KK + L
Sbjct: 353 NEIIQTKLKEIT-EKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQT 411
Query: 131 ENVKIE--ISDLENQANMLK---SEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVF 185
E +K + +S++E + LK +++ ++ ++ + E+ + IQ++ +LK
Sbjct: 412 ETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGE 471
Query: 186 EDEENESICTTKYLEAEKIKISEKPQN----DTECLRLKKELELYKEDDMESVYE--ALQ 239
+ E + K +E K + EK +T+ +L +L K+ ++ E +L
Sbjct: 472 INSEEKQALEAKIVELRK-SLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLM 530
Query: 240 TEIEFLELTL--AQKDLQESK 258
T+I L L + ++K+L ++K
Sbjct: 531 TKINELNLFIDRSEKELDKAK 551
Score = 43.1 bits (100), Expect = 2e-04
Identities = 58/267 (21%), Positives = 122/267 (45%), Gaps = 42/267 (15%)
Query: 8 QHIIFTE--HQAEESRRLMR---EVRSEITRCRE----KIKKATEELNEEKIKLESKVQQ 58
Q I++++ H + RR+ R E+ SE + E +++K+ EE LE+++++
Sbjct: 448 QEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKK 507
Query: 59 FFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNND 118
+F++ KAH +++ S +T + L I+ +K + + F
Sbjct: 508 LHNDLYFIK--KAHSKNSDEKQSLMTKINELNL---------FIDRSEKELDKAKGF--- 553
Query: 119 YEITKKRELLMKENV-KIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFT 177
K++L++++N+ K+E+ + E+ S+E QL ++++E I+ T
Sbjct: 554 -----KQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKT 608
Query: 178 LQRKLKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVY-- 235
+ + D+E E+I T E++ EK +N E L + +E+ ++ Y
Sbjct: 609 MLASQIRYVDQERENISTE---FRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVI 665
Query: 236 ------EALQTEIEFLE--LTLAQKDL 254
E LQ E + L+ + A+K++
Sbjct: 666 KAAQEKEELQREGDCLDAKINKAEKEI 692
>gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 52.0 bits (123), Expect = 5e-07
Identities = 62/246 (25%), Positives = 107/246 (43%), Gaps = 40/246 (16%)
Query: 6 LFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFF 65
LF+ I + A++ R+ RE+ E T ++ ++ LN +F
Sbjct: 786 LFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLN----------------AFA 829
Query: 66 LQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKR 125
+ H + Q ++L + + ++ E++ E + D E+ +
Sbjct: 830 NEDFSCHGDLNTDQLK-----MDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVL-HQ 883
Query: 126 ELLMKENVKIEISDLENQANMLKSEMKS----MEHDSSQLNELQKQKSELIQELFTLQRK 181
ELL NV+ + LE ML+ E+ + ME D +L +LQ+ KSEL +
Sbjct: 884 ELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDER------- 936
Query: 182 LKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELEL----YKEDDMESVYEA 237
V E E+ E I K E EK ++ + +++T L+ KKEL L K M++ YE
Sbjct: 937 -AVQEIEKLEEIHLQKQAEYEK-QLEQLNKDNTASLK-KKELTLKDVECKFSKMKTAYEE 993
Query: 238 LQTEIE 243
+ TE+E
Sbjct: 994 VTTELE 999
Score = 40.4 bits (93), Expect = 0.002
Identities = 52/206 (25%), Positives = 89/206 (43%), Gaps = 26/206 (12%)
Query: 28 RSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITNHR 87
R E + +K A+EE E + E+K Q + ++ + Y +
Sbjct: 389 RKERAKAEHNLKVASEEKQERLQRSENKQPQDSQ---------SYGKKKDAMYGNFMLKK 439
Query: 88 N--MLLQTFEAIKKQMIEEEDKFIKE---ITDFNNDYEITKKRELLMKENVKIEISDLEN 142
+ ML + AIK + +E K+I+E IT+ N ++E K L ++ + ++
Sbjct: 440 DIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFE---KSVRLNEKMITKTVARYSQ 496
Query: 143 QANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLE-- 200
Q N LK+E + +S+L + + K L E+ +L L +E NE I K LE
Sbjct: 497 QLNDLKAENARL---NSELEKEKHNKERLEAEVESLHSSLATAINEYNE-IVERKDLELV 552
Query: 201 ---AEKIKISEKPQNDTECLRLKKEL 223
A+ + EK ++ L K EL
Sbjct: 553 LWRADDVSRHEKMGSNISQLTDKNEL 578
Score = 35.4 bits (80), Expect = 0.050
Identities = 38/216 (17%), Positives = 96/216 (44%), Gaps = 39/216 (18%)
Query: 36 EKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFE 95
EK++K + L EE + L++ +++ + L L+ +++ L+++ +Q E
Sbjct: 896 EKLEKDKKMLEEEVLNLKTHMEKDMVE---LGKLQEYKSELDER----------AVQEIE 942
Query: 96 AIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSME 155
+++ ++++ ++ K++ N D + K++ L ++V+ + S ++ + +E++ +
Sbjct: 943 KLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFK 1002
Query: 156 HD-----------SSQLNELQKQKSELIQELFTLQRKLKVF--------------EDEEN 190
S +L + K+ + + +LFT ++++K F + N
Sbjct: 1003 EAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLN 1062
Query: 191 ESICTTKYLEAEKIKI-SEKPQNDTECLRLKKELEL 225
KY+ I+I + PQ C E+ L
Sbjct: 1063 SIELNRKYIPKTAIRIPTSNPQTSNNCKNFLTEVLL 1098
>gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1002
Score = 52.0 bits (123), Expect = 5e-07
Identities = 62/246 (25%), Positives = 107/246 (43%), Gaps = 40/246 (16%)
Query: 6 LFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFF 65
LF+ I + A++ R+ RE+ E T ++ ++ LN +F
Sbjct: 679 LFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLN----------------AFA 722
Query: 66 LQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKR 125
+ H + Q ++L + + ++ E++ E + D E+ +
Sbjct: 723 NEDFSCHGDLNTDQLK-----MDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVL-HQ 776
Query: 126 ELLMKENVKIEISDLENQANMLKSEMKS----MEHDSSQLNELQKQKSELIQELFTLQRK 181
ELL NV+ + LE ML+ E+ + ME D +L +LQ+ KSEL +
Sbjct: 777 ELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDER------- 829
Query: 182 LKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELEL----YKEDDMESVYEA 237
V E E+ E I K E EK ++ + +++T L+ KKEL L K M++ YE
Sbjct: 830 -AVQEIEKLEEIHLQKQAEYEK-QLEQLNKDNTASLK-KKELTLKDVECKFSKMKTAYEE 886
Query: 238 LQTEIE 243
+ TE+E
Sbjct: 887 VTTELE 892
Score = 40.4 bits (93), Expect = 0.002
Identities = 52/206 (25%), Positives = 89/206 (43%), Gaps = 26/206 (12%)
Query: 28 RSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITNHR 87
R E + +K A+EE E + E+K Q + ++ + Y +
Sbjct: 282 RKERAKAEHNLKVASEEKQERLQRSENKQPQDSQ---------SYGKKKDAMYGNFMLKK 332
Query: 88 N--MLLQTFEAIKKQMIEEEDKFIKE---ITDFNNDYEITKKRELLMKENVKIEISDLEN 142
+ ML + AIK + +E K+I+E IT+ N ++E K L ++ + ++
Sbjct: 333 DIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFE---KSVRLNEKMITKTVARYSQ 389
Query: 143 QANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLE-- 200
Q N LK+E + +S+L + + K L E+ +L L +E NE I K LE
Sbjct: 390 QLNDLKAENARL---NSELEKEKHNKERLEAEVESLHSSLATAINEYNE-IVERKDLELV 445
Query: 201 ---AEKIKISEKPQNDTECLRLKKEL 223
A+ + EK ++ L K EL
Sbjct: 446 LWRADDVSRHEKMGSNISQLTDKNEL 471
>gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 52.0 bits (123), Expect = 5e-07
Identities = 62/246 (25%), Positives = 107/246 (43%), Gaps = 40/246 (16%)
Query: 6 LFQHIIFTEHQAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFF 65
LF+ I + A++ R+ RE+ E T ++ ++ LN +F
Sbjct: 786 LFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLN----------------AFA 829
Query: 66 LQLLKAHENALEKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKR 125
+ H + Q ++L + + ++ E++ E + D E+ +
Sbjct: 830 NEDFSCHGDLNTDQLK-----MDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVL-HQ 883
Query: 126 ELLMKENVKIEISDLENQANMLKSEMKS----MEHDSSQLNELQKQKSELIQELFTLQRK 181
ELL NV+ + LE ML+ E+ + ME D +L +LQ+ KSEL +
Sbjct: 884 ELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDER------- 936
Query: 182 LKVFEDEENESICTTKYLEAEKIKISEKPQNDTECLRLKKELEL----YKEDDMESVYEA 237
V E E+ E I K E EK ++ + +++T L+ KKEL L K M++ YE
Sbjct: 937 -AVQEIEKLEEIHLQKQAEYEK-QLEQLNKDNTASLK-KKELTLKDVECKFSKMKTAYEE 993
Query: 238 LQTEIE 243
+ TE+E
Sbjct: 994 VTTELE 999
Score = 40.4 bits (93), Expect = 0.002
Identities = 52/206 (25%), Positives = 89/206 (43%), Gaps = 26/206 (12%)
Query: 28 RSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITNHR 87
R E + +K A+EE E + E+K Q + ++ + Y +
Sbjct: 389 RKERAKAEHNLKVASEEKQERLQRSENKQPQDSQ---------SYGKKKDAMYGNFMLKK 439
Query: 88 N--MLLQTFEAIKKQMIEEEDKFIKE---ITDFNNDYEITKKRELLMKENVKIEISDLEN 142
+ ML + AIK + +E K+I+E IT+ N ++E K L ++ + ++
Sbjct: 440 DIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFE---KSVRLNEKMITKTVARYSQ 496
Query: 143 QANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLE-- 200
Q N LK+E + +S+L + + K L E+ +L L +E NE I K LE
Sbjct: 497 QLNDLKAENARL---NSELEKEKHNKERLEAEVESLHSSLATAINEYNE-IVERKDLELV 552
Query: 201 ---AEKIKISEKPQNDTECLRLKKEL 223
A+ + EK ++ L K EL
Sbjct: 553 LWRADDVSRHEKMGSNISQLTDKNEL 578
Score = 35.4 bits (80), Expect = 0.050
Identities = 38/216 (17%), Positives = 96/216 (44%), Gaps = 39/216 (18%)
Query: 36 EKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFE 95
EK++K + L EE + L++ +++ + L L+ +++ L+++ +Q E
Sbjct: 896 EKLEKDKKMLEEEVLNLKTHMEKDMVE---LGKLQEYKSELDER----------AVQEIE 942
Query: 96 AIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIEISDLENQANMLKSEMKSME 155
+++ ++++ ++ K++ N D + K++ L ++V+ + S ++ + +E++ +
Sbjct: 943 KLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFK 1002
Query: 156 HD-----------SSQLNELQKQKSELIQELFTLQRKLKVF--------------EDEEN 190
S +L + K+ + + +LFT ++++K F + N
Sbjct: 1003 EAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLN 1062
Query: 191 ESICTTKYLEAEKIKI-SEKPQNDTECLRLKKELEL 225
KY+ I+I + PQ C E+ L
Sbjct: 1063 SIELNRKYIPKTAIRIPTSNPQTSNNCKNFLTEVLL 1098
>gi|112420968 coiled-coil domain containing 158 [Homo sapiens]
Length = 1113
Score = 52.0 bits (123), Expect = 5e-07
Identities = 49/228 (21%), Positives = 111/228 (48%), Gaps = 20/228 (8%)
Query: 43 EELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEKQYSEITNHRNMLLQTFEAIKK--- 99
+E+N+ +++L+ +K ++ L+A + LE + ++ N + L+ + IK+
Sbjct: 597 KEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERD 656
Query: 100 QMIEEEDKFIKEITDFNNDYEITKKR------ELLMKEN-VKIEISDLENQANMLKSEMK 152
Q++ E E+ + + +YE+ K+ E+ M N +K+++ +++ ++ +K
Sbjct: 657 QLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLK 716
Query: 153 SME----HDSSQLNELQKQKSELIQELFTLQRKLKVFEDEENESICTTKYLEAEKIKISE 208
SME H +QKQ + ++ LQ K++ E+ + +L+ EK K+S+
Sbjct: 717 SMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQ 776
Query: 209 KPQN-DTECLRLKKELELYKEDDMESVYEALQTEIEFLELTLAQKDLQ 255
+ TE ++ ELE+ + + L+ ++ +E+ L + LQ
Sbjct: 777 ELSTVATEKNKMAGELEVLRSQE-----RRLKEKVTNMEVALDKASLQ 819
Score = 47.8 bits (112), Expect = 1e-05
Identities = 48/240 (20%), Positives = 109/240 (45%), Gaps = 17/240 (7%)
Query: 22 RLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEK--SFFLQLLKAHE---NAL 76
+++RE+ +EI+ + +I ++L K + ++K++ ++ QL+ HE L
Sbjct: 224 KILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGL 283
Query: 77 EKQYSEITNHRNMLLQTFEAIKKQMIEEEDKFIKEITDFNNDYEITKKRELLMKENVKIE 136
++ S + N + E I++Q + ++++++D + + K + +
Sbjct: 284 TEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDK 343
Query: 137 ISDLENQANMLKSEMKSMEHDSSQLNE----LQKQKSELIQELFTLQRKLKVFEDEENES 192
+LE Q + SE+ + Q ++ L Q +L+ +L +++L + E E+N+
Sbjct: 344 TEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSL-EKEQNKR 402
Query: 193 IC---TTKYLEAEKIKISEKPQNDTECLRLKKELELYKED---DMESVYEALQTEIEFLE 246
+ T + + ++ E + E RL+ L+ K + ME A+Q + E LE
Sbjct: 403 LWDRDTGNSITIDHLR-RELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLE 461
Score = 45.1 bits (105), Expect = 6e-05
Identities = 58/265 (21%), Positives = 128/265 (48%), Gaps = 35/265 (13%)
Query: 19 ESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQFFEKSFFLQLLKAHENALEK 78
ES + + +++ +E ++K EEL +K+ LES + + + LQ E A+E
Sbjct: 458 ESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQ---EKERAIEA 514
Query: 79 QYSEITNHR---NMLLQTFEAIKKQ-----MIEEEDKFIK-EITDFNNDYEITKKRELLM 129
+EIT R ++ LQ + +K + ++ E + +K ++T+ + EI +++ M
Sbjct: 515 TNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENM 574
Query: 130 KENV----------KIEISDLENQANMLKSEMKSM----EHDSSQLNELQKQKSELIQEL 175
+ V ++E + LE + N + E+K + + +++ EL+ + S+L E
Sbjct: 575 TQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELE- 633
Query: 176 FTLQRKLKVFEDEENESICTTKYLEAEKIK-ISEKPQNDTECLRLKKELELYKEDDMESV 234
K+K+ + +E + K ++ E+ + ++E + +E L +E E+ K +
Sbjct: 634 -----KVKLV-NAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKS 687
Query: 235 YEALQTEIEF-LELTLAQKDLQESK 258
E T + ++L AQ +L++++
Sbjct: 688 EEMEMTTNKLKMQLKSAQSELEQTR 712
Score = 43.1 bits (100), Expect = 2e-04
Identities = 54/248 (21%), Positives = 107/248 (43%), Gaps = 14/248 (5%)
Query: 16 QAEESRRLMREVRSEITRCREKIKKATEELNEEKIKLESKVQQF-FEKSFFLQLLKAHEN 74
Q + + ++RSE+ + + TEEL ++ + S++ + E+ F Q ++
Sbjct: 318 QLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDD 377
Query: 75 ALEKQYSEITNHRNMLLQTFEAIKKQMIEEE------DKFIKEITDFNNDYEITKKRELL 128
L+K +++ L E K+ + D +E+ + N + ++ E L
Sbjct: 378 QLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNME---VQRLEAL 434
Query: 129 MKENVKIEISDLENQANMLKSEMKSMEHDSSQLNELQKQKSELIQELFTLQRKLKVFEDE 188
+K +E Q ++ + +S+E SS +L+ K L + + L K E
Sbjct: 435 LKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESS 494
Query: 189 ENESICTTKYLEAEKIKISEKPQNDTECLRLKKELELYKEDDMESVYEAL---QTEIEFL 245
E T L+ EK + E + LR + +L+L + +++ + L QTE E L
Sbjct: 495 ERTISDLTTSLQ-EKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEAL 553
Query: 246 ELTLAQKD 253
+L + +KD
Sbjct: 554 KLQMTEKD 561
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.323
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,883,535
Number of Sequences: 37866
Number of extensions: 336929
Number of successful extensions: 4880
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 183
Number of HSP's successfully gapped in prelim test: 734
Number of HSP's that attempted gapping in prelim test: 2711
Number of HSP's gapped (non-prelim): 2179
length of query: 258
length of database: 18,247,518
effective HSP length: 100
effective length of query: 158
effective length of database: 14,460,918
effective search space: 2284825044
effective search space used: 2284825044
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.