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Search of human proteins with 34365793
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34365793 WNK lysine deficient protein kinase 4 [Homo
sapiens]
(1243 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens] 2502 0.0
gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens] 619 e-177
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens] 580 e-165
gi|50845418 WNK lysine deficient protein kinase 3 isoform 1 [Hom... 560 e-159
gi|50845416 WNK lysine deficient protein kinase 3 isoform 2 [Hom... 560 e-159
gi|7019333 nuclear receptor binding protein [Homo sapiens] 145 3e-34
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 119 2e-26
gi|19424132 NIMA-related kinase 7 [Homo sapiens] 116 2e-25
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 114 6e-25
gi|55956904 mitogen-activated protein kinase kinase kinase 4 iso... 113 1e-24
gi|55956902 mitogen-activated protein kinase kinase kinase 4 iso... 113 1e-24
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 113 1e-24
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 113 1e-24
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 113 1e-24
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 113 1e-24
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 113 1e-24
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 113 1e-24
gi|42794767 mitogen-activated protein kinase kinase kinase 3 iso... 111 5e-24
gi|42794765 mitogen-activated protein kinase kinase kinase 3 iso... 111 5e-24
gi|32483399 p21-activated kinase 2 [Homo sapiens] 110 8e-24
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens] 110 8e-24
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens] 110 8e-24
gi|191252782 p21-activated kinase 6 [Homo sapiens] 109 2e-23
gi|191252780 p21-activated kinase 6 [Homo sapiens] 109 2e-23
gi|9910476 p21-activated kinase 6 [Homo sapiens] 109 2e-23
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 108 2e-23
gi|121583542 mitogen-activated protein kinase kinase kinase 15 [... 108 2e-23
gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens] 108 3e-23
gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens] 108 3e-23
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 108 3e-23
>gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]
Length = 1243
Score = 2502 bits (6484), Expect = 0.0
Identities = 1243/1243 (100%), Positives = 1243/1243 (100%)
Query: 1 MLASPATETTVLMSQTEADLALRPPPPLGTAGQPRLGPPPRRARRFSGKAEPRPRSSRLS 60
MLASPATETTVLMSQTEADLALRPPPPLGTAGQPRLGPPPRRARRFSGKAEPRPRSSRLS
Sbjct: 1 MLASPATETTVLMSQTEADLALRPPPPLGTAGQPRLGPPPRRARRFSGKAEPRPRSSRLS 60
Query: 61 RRSSVDLGLLSSWSLPASPAPDPPDPPDSAGPGPARSPPPSSKEPPEGTWTEGAPVKAAE 120
RRSSVDLGLLSSWSLPASPAPDPPDPPDSAGPGPARSPPPSSKEPPEGTWTEGAPVKAAE
Sbjct: 61 RRSSVDLGLLSSWSLPASPAPDPPDPPDSAGPGPARSPPPSSKEPPEGTWTEGAPVKAAE 120
Query: 121 DSARPELPDSAVGPGSREPLRVPEAVALERRREQEEKEDMETQAVATSPDGRYLKFDIEI 180
DSARPELPDSAVGPGSREPLRVPEAVALERRREQEEKEDMETQAVATSPDGRYLKFDIEI
Sbjct: 121 DSARPELPDSAVGPGSREPLRVPEAVALERRREQEEKEDMETQAVATSPDGRYLKFDIEI 180
Query: 181 GRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSW 240
GRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSW
Sbjct: 181 GRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSW 240
Query: 241 KSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILH 300
KSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILH
Sbjct: 241 KSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILH 300
Query: 301 RDLKCDNVFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYA 360
RDLKCDNVFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYA
Sbjct: 301 RDLKCDNVFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYA 360
Query: 361 FGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEIIEGCIRTDKNER 420
FGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEIIEGCIRTDKNER
Sbjct: 361 FGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEIIEGCIRTDKNER 420
Query: 421 FTIQDLLAHAFFREERGVHVELAEEDDGEKPGLKLWLRMEDARRGGRPRDNQAIEFLFQL 480
FTIQDLLAHAFFREERGVHVELAEEDDGEKPGLKLWLRMEDARRGGRPRDNQAIEFLFQL
Sbjct: 421 FTIQDLLAHAFFREERGVHVELAEEDDGEKPGLKLWLRMEDARRGGRPRDNQAIEFLFQL 480
Query: 481 GRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQRKREKLRKARELEALPPEPGPP 540
GRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQRKREKLRKARELEALPPEPGPP
Sbjct: 481 GRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQRKREKLRKARELEALPPEPGPP 540
Query: 541 PATVPMAPGPPSVFPPEPEEPEADQHQPFLFRHASYSSTTSDCETDGYLSSSGFLDASDP 600
PATVPMAPGPPSVFPPEPEEPEADQHQPFLFRHASYSSTTSDCETDGYLSSSGFLDASDP
Sbjct: 541 PATVPMAPGPPSVFPPEPEEPEADQHQPFLFRHASYSSTTSDCETDGYLSSSGFLDASDP 600
Query: 601 ALQPPGGVPSSLAESHLCLPSAFALSIPRSGPGSDFSPGDSYASDAASGLSDVGEGMGQM 660
ALQPPGGVPSSLAESHLCLPSAFALSIPRSGPGSDFSPGDSYASDAASGLSDVGEGMGQM
Sbjct: 601 ALQPPGGVPSSLAESHLCLPSAFALSIPRSGPGSDFSPGDSYASDAASGLSDVGEGMGQM 660
Query: 661 RRPPGRNLRRRPRSRLRVTSVSDQNDRVVECQLQTHNSKMVTFRFDLDGDSPEEIAAAMV 720
RRPPGRNLRRRPRSRLRVTSVSDQNDRVVECQLQTHNSKMVTFRFDLDGDSPEEIAAAMV
Sbjct: 661 RRPPGRNLRRRPRSRLRVTSVSDQNDRVVECQLQTHNSKMVTFRFDLDGDSPEEIAAAMV 720
Query: 721 YNEFILPSERDGFLRRIREIIQRVETLLKRDTGPMEAAEDTLSPQEEPAPLPALPVPLPD 780
YNEFILPSERDGFLRRIREIIQRVETLLKRDTGPMEAAEDTLSPQEEPAPLPALPVPLPD
Sbjct: 721 YNEFILPSERDGFLRRIREIIQRVETLLKRDTGPMEAAEDTLSPQEEPAPLPALPVPLPD 780
Query: 781 PSNEELQSSTSLEHRSWTAFSTSSSSPGTPLSPGNPFSPGTPISPGPIFPITSPPCHPSP 840
PSNEELQSSTSLEHRSWTAFSTSSSSPGTPLSPGNPFSPGTPISPGPIFPITSPPCHPSP
Sbjct: 781 PSNEELQSSTSLEHRSWTAFSTSSSSPGTPLSPGNPFSPGTPISPGPIFPITSPPCHPSP 840
Query: 841 SPFSPISSQVSSNPSPHPTSSPLPFSSSTPEFPVPLSQCPWSSLPTTSPPTFSPTCSQVT 900
SPFSPISSQVSSNPSPHPTSSPLPFSSSTPEFPVPLSQCPWSSLPTTSPPTFSPTCSQVT
Sbjct: 841 SPFSPISSQVSSNPSPHPTSSPLPFSSSTPEFPVPLSQCPWSSLPTTSPPTFSPTCSQVT 900
Query: 901 LSSPFFPPCPSTSSFPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPSPL 960
LSSPFFPPCPSTSSFPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPSPL
Sbjct: 901 LSSPFFPPCPSTSSFPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPSPL 960
Query: 961 PSLPLPPPVAPGGQESPSPHTAEVESEASPPPARPLPGEARLAPISEEGKPQLVGRFQVT 1020
PSLPLPPPVAPGGQESPSPHTAEVESEASPPPARPLPGEARLAPISEEGKPQLVGRFQVT
Sbjct: 961 PSLPLPPPVAPGGQESPSPHTAEVESEASPPPARPLPGEARLAPISEEGKPQLVGRFQVT 1020
Query: 1021 SSKEPAEPLPLQPTSPTLSGSPKPSTPQLTSESSDTEDSAGGGPETREALAESDRAAEGL 1080
SSKEPAEPLPLQPTSPTLSGSPKPSTPQLTSESSDTEDSAGGGPETREALAESDRAAEGL
Sbjct: 1021 SSKEPAEPLPLQPTSPTLSGSPKPSTPQLTSESSDTEDSAGGGPETREALAESDRAAEGL 1080
Query: 1081 GAGVEEEGDDGKEPQVGGSPQPLSHPSPVWMNYSYSSLCLSSEESESSGEDEEFWAELQS 1140
GAGVEEEGDDGKEPQVGGSPQPLSHPSPVWMNYSYSSLCLSSEESESSGEDEEFWAELQS
Sbjct: 1081 GAGVEEEGDDGKEPQVGGSPQPLSHPSPVWMNYSYSSLCLSSEESESSGEDEEFWAELQS 1140
Query: 1141 LRQKHLSEVETLQTLQKKEIEDLYSRLGKQPPPGIVAPAAMLSSRQRRLSKGSFPTSRRN 1200
LRQKHLSEVETLQTLQKKEIEDLYSRLGKQPPPGIVAPAAMLSSRQRRLSKGSFPTSRRN
Sbjct: 1141 LRQKHLSEVETLQTLQKKEIEDLYSRLGKQPPPGIVAPAAMLSSRQRRLSKGSFPTSRRN 1200
Query: 1201 SLQRSEPPGPGIMRRNSLSGSSTGSQEQRASKGVTFAGDVGRM 1243
SLQRSEPPGPGIMRRNSLSGSSTGSQEQRASKGVTFAGDVGRM
Sbjct: 1201 SLQRSEPPGPGIMRRNSLSGSSTGSQEQRASKGVTFAGDVGRM 1243
>gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens]
Length = 2382
Score = 619 bits (1595), Expect = e-177
Identities = 406/967 (41%), Positives = 518/967 (53%), Gaps = 85/967 (8%)
Query: 32 GQPRLGPPPRRARRFSGKAEPRPRSSRLSRRSSVDLGLLSSWSLPASPAPDPPDPPDSAG 91
G P P P A P P R +S PA P AG
Sbjct: 97 GLPLSLPQPSIPAAVPQSAPPEPH------REETVTATATSQVAQQPPAAAAPGEQAVAG 150
Query: 92 PGPARSPPPSSKEPPEGTWTEGAPVKAAEDSARPELPDSAVGPGSREPLRVPEAVALERR 151
P P+ P +SK+ P P P + G ++EP ER
Sbjct: 151 PAPSTVPSSTSKDRPVSQ-----PSLVGSKEEPPPARSGSGGGSAKEPQE-------ERS 198
Query: 152 REQEEKEDMETQAVATSPDGRYLKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLS 211
++Q++ E++ET+AV S DGR+LKFDIEIGRGSFKTVY+GLDT+TTVEVAWCELQ RKL+
Sbjct: 199 QQQDDIEELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLT 258
Query: 212 RAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFRE 271
++ERQRF EE EMLKGLQHPNIVRFYDSW+S ++G+ CIVLVTELMTSGTLKTYL+RF+
Sbjct: 259 KSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKV 318
Query: 272 MKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATLKRAS 331
MK +VL+ W RQIL+GL FLH+R PPI+HRDLKCDN+FITGPTGSVKIGDLGLATLKRAS
Sbjct: 319 MKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRAS 378
Query: 332 FAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSG 391
FAKSVIGTPEFMAPEMYEEKYDE+VDVYAFGMCMLEMATSEYPYSECQNAAQIYR+VTSG
Sbjct: 379 FAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSG 438
Query: 392 RKPNSFHKVKIPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREERGVHVELAEEDDGEKP 451
KP SF KV IPEVKEIIEGCIR +K+ER++I+DLL HAFF+EE GV VELAEEDDGEK
Sbjct: 439 VKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVELAEEDDGEKI 498
Query: 452 GLKLWLRMEDARR-GGRPRDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVARAV 510
+KLWLR+ED ++ G+ +DN+AIEF F L RD E+VAQEMV G VCE D++ +A+A+
Sbjct: 499 AIKLWLRIEDIKKLKGKYKDNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAI 558
Query: 511 RERVAAIQRKREKLRKARE-------------------------LEALP-PEPGPPPATV 544
++RV+ I+RKRE+ + RE ++ LP G P A+
Sbjct: 559 KDRVSLIKRKREQRQLVREEQEKKKQEESSLKQQVEQSSASQTGIKQLPSASTGIPTAST 618
Query: 545 PMAPGPPSVFPPEPEEPEADQHQPFLFRHASYSSTTSDCETDGYLSSSGFLDASDPALQP 604
A V EPEEPEADQHQ ++ S S SD D SS F ++ + Q
Sbjct: 619 TSASVSTQV---EPEEPEADQHQQLQYQQPSI-SVLSDGTVDSGQGSSVFTESRVSSQQT 674
Query: 605 PG-GVPSSLAESHLCLPSAFALSIPRSGPGSDFSPGDSYASDAASGLSDVGEGMGQMRRP 663
G A S +P ++ P S A + G G
Sbjct: 675 VSYGSQHEQAHSTGTVPGHIPSTVQAQSQPHGVYPPSSVAQGQSQGQPSSSSLTGVSSSQ 734
Query: 664 PGRNLRRRPRSRLRVTSVSDQNDRVVECQLQTHNSKMVTFRFDLDGDSPEEIAAAMVYNE 723
P + P+ + + + V QT S T + ++ + +
Sbjct: 735 P----IQHPQQQQGIQQTAPPQQTVQYSLSQTSTSSEATTAQPVSQPQAPQVLPQVSAGK 790
Query: 724 FILPSERDGFLRRIREIIQRVETLLKRDTGPMEAAEDTLSPQEEPAPLPALP------VP 777
+ S+ ++ +I + P+ + L P +P P P LP +P
Sbjct: 791 QLPVSQPVPTIQGEPQI----PVATQPSVVPVHSGAHFL-PVGQPLPTPLLPQYPVSQIP 845
Query: 778 LPDPSNEELQSSTSLEHRSWTA-----FSTSSSSPGTPLSPGNPFSPGTPIS-PGPIFPI 831
+ P Q+ S + A T +SS T PG S P P + P+
Sbjct: 846 ISTPHVSTAQTGFSSLPITMAAGITQPLLTLASSATTAAIPG--VSTVVPSQLPTLLQPV 903
Query: 832 TSPPCHPSPSPFSPISSQVSSNPSPHPTSSPLPFSSSTPEFPVPLSQCPWSSLPTTSPPT 891
T P P P + Q P+ ++ +P SS + P PP
Sbjct: 904 TQLPSQVHPQLLQP-AVQSMGIPANLGQAAEVPLSS---------GDVLYQGFPPRLPPQ 953
Query: 892 FSPTCSQVTLSSPFFPPCPSTSSFPSTTAAPLLSLASAFSLAVMTVAQS-LLSPSPGLLS 950
+ P S + SS C ++ +L+ F V +S LL P G+
Sbjct: 954 Y-PGDSNIAPSSNVASVCIHSTVLSPPMPTEVLATPGYFPTVVQPYVESNLLVPMGGVGG 1012
Query: 951 QSPPAPP 957
Q + P
Sbjct: 1013 QVQVSQP 1019
Score = 127 bits (320), Expect = 5e-29
Identities = 126/458 (27%), Positives = 193/458 (42%), Gaps = 92/458 (20%)
Query: 590 SSSGFLDASDPALQPPGGVPSSLAESHLCLPSAFALSIPRSGPGSDFSPGDSYASDAASG 649
S L+++ Q P ++A++ P+ A S+ DS SD ASG
Sbjct: 1031 SQQAVLESTQGVSQVAPAEPVAVAQTQATQPTTLASSV------------DSAHSDVASG 1078
Query: 650 LSDVGEGM-GQMRRPPGRNLRR------RPRSR--------LRVTSVSDQNDRVVECQLQ 694
+SD E + R GR +R R RSR LR+ +VS++ DRVVECQL+
Sbjct: 1079 MSDGNENVPSSSGRHEGRTTKRHYRKSVRSRSRHEKTSRPKLRILNVSNKGDRVVECQLE 1138
Query: 695 THNSKMVTFRFDLDGDSPEEIAAAMVYNEFILPSERDGFLRRIREIIQRVETLLKRDTGP 754
THN KMVTF+FDLDGD+PEEIA MV N+FIL ER+ F+ ++REII++ + +L D
Sbjct: 1139 THNRKMVTFKFDLDGDNPEEIATIMVNNDFILAIERESFVDQVREIIEKADEMLSEDVSV 1198
Query: 755 MEAAEDTLSPQE------------------EPAPLPALPVPLPDPSNEELQ--------- 787
+ L + +P P ++P + P++ Q
Sbjct: 1199 EPEGDQGLESLQGKDDYGFSGSQKLEGEFKQPIPASSMPQQIGIPTSSLTQVVHSAGRRF 1258
Query: 788 ------SSTSLEHRSWTAFSTSSSSPGTPLSPG-NPFSPGTPISPGPIF----------- 829
S E + + + T + + T SPG N + +S F
Sbjct: 1259 IVSPVPESRLRESKVFPSEITDTVAASTAQSPGMNLSHSASSLSLQQAFSELRRAQMTEG 1318
Query: 830 PITSPP--CHPSPS--PFSPISSQVSSNPSPHPTSSPLPFSSSTP----------EFPVP 875
P T+PP H P+ P S ++ P+ ++P+P +SS P E VP
Sbjct: 1319 PNTAPPNFSHTGPTFPVVPPFLSSIAGVPTTAAATAPVPATSSPPNDISTSVIQSEVTVP 1378
Query: 876 LSQCPWSSLPTTSPPTFSPTCSQVTLSSPFFPPCPSTSSFPS----TTAAPLLSLASAFS 931
+ +T T SP S+ + P+ +T +P L + + S
Sbjct: 1379 TEEGIAGVATSTGVVTSGGLPIPPVSESPVLSSVVSSITIPAVVSISTTSPSLQVPT--S 1436
Query: 932 LAVMTVAQSLLSPSPGLLSQSPPAPPSPLPSLPLPPPV 969
+ + V+ + L PS + + S A S P PP V
Sbjct: 1437 TSEIVVSSTALYPSVTVSATSASAGGSTATPGPKPPAV 1474
Score = 105 bits (262), Expect = 3e-22
Identities = 133/469 (28%), Positives = 192/469 (40%), Gaps = 59/469 (12%)
Query: 801 STSSSSPGTPLSPGNPFSPGTPI-SPG----PIFPITS---PPCHPSPSPFS-----PIS 847
+TS+ P T L G P TP+ +PG P+ TS P PS P + P+
Sbjct: 1706 TTSTCLPPTNLPLGTVALPVTPVVTPGQVSTPVSTTTSGVKPGTAPSKPPLTKAPVLPVG 1765
Query: 848 SQVSSNPSPHPTSSPLPFSSSTPEFPVPLSQCPWSSLPTTSPPTFSPTCSQVTLS-SPFF 906
+++ + P P P S T SQ P L T SP VT + P
Sbjct: 1766 TELPAGTLPSEQLPPFPGPSLTQ------SQQPLEDLDAQLRRTLSPEMITVTSAVGPVS 1819
Query: 907 PPCPSTSSFPSTTAAPLLS-------LASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPSP 959
P+ + T +S LA++ V + + +S + +
Sbjct: 1820 MAAPTAITEAGTQPQKGVSQVKEGPVLATSSGAGVFKMGRFQVSVAADGAQKEGKNKSED 1879
Query: 960 LPSLPLPPPVAPGGQ-ESPSPHTAEVESEAS----PPPARPLPGEARLAPISEE----GK 1010
S+ + S SP + V+ E + P + +P A SE G+
Sbjct: 1880 AKSVHFESSTSESSVLSSSSPESTLVKPEPNGITIPGISSDVPESAHKTTASEAKSDTGQ 1939
Query: 1011 PQLVGRFQVTSSKEPAEPLPLQPTSPTLSGSPKPSTPQLTSESSDTEDSAGGG------- 1063
P VGRFQVT++ + T ++ + K P + D E +
Sbjct: 1940 PTKVGRFQVTTTANKVGRFSVSKTEDKITDTKKEG-PVASPPFMDLEQAVLPAVIPKKEK 1998
Query: 1064 PETREALAESDRAAEGLGAGVEEEGDDGKEPQVGGSPQPLSHPSPVWMNYSYS-----SL 1118
PE E + +++ A + + DDG SP LS S N S S +
Sbjct: 1999 PELSEPSHLNGPSSDPEAAFLSRDVDDGSGSP--HSPHQLSSKSLPSQNLSQSLSNSFNS 2056
Query: 1119 CLSSEESESSGEDEEFWAELQSLRQKHLSEVETLQTLQKKEIEDLYSRLGKQPPPGIVAP 1178
S ++ES EDE+ EL+ LR KHL E++ LQ+ QK EIE LY++LGK PP I+ P
Sbjct: 2057 SYMSSDNESDIEDEDLKLELRRLRDKHLKEIQDLQSRQKHEIESLYTKLGKVPPAVIIPP 2116
Query: 1179 AAMLSSRQRR--LSKGSFPTSRRNSLQRSEPPGPGIMRRNSLSGSSTGS 1225
AA LS R+RR SKGS +SR +SL P G +LSG S S
Sbjct: 2117 AAPLSGRRRRPTKSKGS-KSSRSSSLGNKSPQLSG-----NLSGQSAAS 2159
Score = 48.1 bits (113), Expect = 5e-05
Identities = 87/338 (25%), Positives = 127/338 (37%), Gaps = 56/338 (16%)
Query: 794 HRSWTAFSTSSSSPGTPLSPGNPFS-----PG-------------TPISPGPIFPITSPP 835
H S T + S S+P + SPG S PG TPI P P TS P
Sbjct: 1534 HSSTTGLAFSLSAPSSSSSPGAGVSSYISQPGGLHPLVIPSVIASTPILPQAAGP-TSTP 1592
Query: 836 CHPSPSPFSPISSQVSSNPSPHPT---SSPLPFSSSTPEFPVPLSQCPW--SSLPTTSPP 890
P P+ V++ P+ T S P P P + CP S +P
Sbjct: 1593 LLPQVPSIPPLVQPVANVPAVQQTLIHSQPQPALLPNQ----PHTHCPEVDSDTQPKAPG 1648
Query: 891 TFSPTCSQVTLSSPFFPPCPSTSSFPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLS 950
+ L S F S + S + L + S + + T A ++PS L S
Sbjct: 1649 IDDIKTLEEKLRSLFSEHSSSGAQHASVSLETSLVIESTVTPGIPTTA---VAPSKLLTS 1705
Query: 951 QSPPA-PPSPLP----SLPLPPPVAPGGQESP--------SPHTAEVESEASPPPARPLP 997
+ PP+ LP +LP+ P V PG +P P TA + + P P+
Sbjct: 1706 TTSTCLPPTNLPLGTVALPVTPVVTPGQVSTPVSTTTSGVKPGTAPSKPPLTKAPVLPVG 1765
Query: 998 GEARLAPISEEGKPQLVGRFQVTSSKEPAEPL------PLQPTSPTLSGSPKPSTPQLTS 1051
E + E P G +T S++P E L L P T++ + P + + +
Sbjct: 1766 TELPAGTLPSEQLPPFPGP-SLTQSQQPLEDLDAQLRRTLSPEMITVTSAVGPVS--MAA 1822
Query: 1052 ESSDTEDSAGGGPETR-EALAESDRAAEGLGAGVEEEG 1088
++ TE AG P+ + E A GAGV + G
Sbjct: 1823 PTAITE--AGTQPQKGVSQVKEGPVLATSSGAGVFKMG 1858
Score = 42.7 bits (99), Expect = 0.002
Identities = 90/447 (20%), Positives = 151/447 (33%), Gaps = 94/447 (21%)
Query: 697 NSKMVTFRFDLDGDSPEEIAAAMVYNEFILPSERDGFLRRIREIIQRVET------LLKR 750
+++ + F FDL+ D PE++A MV + ++ + + I++ + ++ L++
Sbjct: 518 DNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQLVRE 577
Query: 751 DTGPMEAAEDTLSPQEEPAP--------LPALPVPLPDPSNEELQSSTSLEHRSWTAF-- 800
+ + E +L Q E + LP+ +P S ST +E A
Sbjct: 578 EQEKKKQEESSLKQQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQVEPEEPEADQH 637
Query: 801 --------STSSSSPGTPLS---------------------------------PGN-PFS 818
S S S GT S PG+ P +
Sbjct: 638 QQLQYQQPSISVLSDGTVDSGQGSSVFTESRVSSQQTVSYGSQHEQAHSTGTVPGHIPST 697
Query: 819 PGTPISPGPIFPITS-----PPCHPSPSPFSPISSQVSSNPSPHPTSSPLPFSSSTPEFP 873
P ++P +S PS S + +SS S P HP ++ P+
Sbjct: 698 VQAQSQPHGVYPPSSVAQGQSQGQPSSSSLTGVSS---SQPIQHPQQQQGIQQTAPPQQT 754
Query: 874 VP--LSQCPWSSLPTTSPPTFSPTCSQVTLSSPFFPPCPSTSSFPSTTAAPLLSLASAFS 931
V LSQ SS TT+ P P QV P + P+ P + +A+ S
Sbjct: 755 VQYSLSQTSTSSEATTAQPVSQPQAPQVLPQVSAGKQLPVSQPVPTIQGEPQIPVATQPS 814
Query: 932 LAVMTVAQSLLSPSPGLLSQSPPAPPSPLPSLPLPPPVAPGGQESPSP--------HTAE 983
+ + L L +P P P+ +P+ P Q S T
Sbjct: 815 VVPVHSGAHFLPVGQPL--PTPLLPQYPVSQIPISTPHVSTAQTGFSSLPITMAAGITQP 872
Query: 984 VESEASPPPARPLPGEARLAP------------ISEEGKPQL----VGRFQVTSSKEPAE 1027
+ + AS +PG + + P + + PQL V + ++ A
Sbjct: 873 LLTLASSATTAAIPGVSTVVPSQLPTLLQPVTQLPSQVHPQLLQPAVQSMGIPANLGQAA 932
Query: 1028 PLPLQPTSPTLSGSPKPSTPQLTSESS 1054
+PL G P PQ +S+
Sbjct: 933 EVPLSSGDVLYQGFPPRLPPQYPGDSN 959
Score = 33.1 bits (74), Expect = 1.7
Identities = 31/93 (33%), Positives = 37/93 (39%), Gaps = 6/93 (6%)
Query: 771 LPALPVPLPDPSNEEL--QSSTSLEHRSWTAFSTSSSSPGTPLSPGNPFSPGTPISPGPI 828
LP LP+ LP PS QS+ HR T +T++S P +PG GP
Sbjct: 95 LPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATSQ--VAQQPPAAAAPGEQAVAGPA 152
Query: 829 FPITSPPCHPSPSPFSPISSQVSSNPSPHPTSS 861
P T P P S S V S P P S
Sbjct: 153 -PSTVPSSTSKDRPVSQ-PSLVGSKEEPPPARS 183
Score = 32.7 bits (73), Expect = 2.2
Identities = 37/116 (31%), Positives = 48/116 (41%), Gaps = 21/116 (18%)
Query: 960 LPSLPL--PPPVAPGG---QESPSPH-----TAEVESE-ASPPPARPLPGEARLA----- 1003
LP LPL P P P P PH TA S+ A PPA PGE +A
Sbjct: 95 LPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATSQVAQQPPAAAAPGEQAVAGPAPS 154
Query: 1004 -PISEEGKPQLVGRFQVTSSKEPAEPLPLQPTSPTLSGSPKPSTPQLTSESSDTED 1058
S K + V + + SKE EP P + S + GS K + + + D E+
Sbjct: 155 TVPSSTSKDRPVSQPSLVGSKE--EPPPAR--SGSGGGSAKEPQEERSQQQDDIEE 206
>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
Length = 2217
Score = 580 bits (1494), Expect = e-165
Identities = 346/667 (51%), Positives = 414/667 (62%), Gaps = 56/667 (8%)
Query: 3 ASPATETTVLMSQTEADLALRPPPPLGTAGQPRLGPPPRRARRFSGKAEPRPRSSRLSR- 61
A P + + S E+D PP L A P PP RR + R + +R
Sbjct: 34 ARPGPQRFLRRSVVESDQ--EEPPGLEAAEAPGPQPPQPLQRRVLLLCKTRRLIAERARG 91
Query: 62 --RSSVDLGLLSSWSLPASPAPDPPDPPDSAGPGPARSPPPSSKEPPEGTWTEGAPVKAA 119
+ L++ P +PA P+P + PGP P + +G P + A
Sbjct: 92 RPAAPAPAALVAQPGAPGAPADAGPEPVGTQEPGP----DPIAAAVETAPAPDGGPREEA 147
Query: 120 EDSARPELPDSAVGPGSREPLRVPEAVALERRREQEEKEDMET--QAVATSPDGRYLKFD 177
+ R E D EP R RR E EE+ED E +AVATS DGR+LKFD
Sbjct: 148 AATVRKE--DEGAAEAKPEPGRT-------RRDEPEEEEDDEDDLKAVATSLDGRFLKFD 198
Query: 178 IEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFY 237
IE+GRGSFKTVY+GLDT+T VEVAWCELQ RKL++ ERQRF EE EMLKGLQHPNIVRFY
Sbjct: 199 IELGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKLERQRFKEEAEMLKGLQHPNIVRFY 258
Query: 238 DSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPP 297
D W+S +G+ CIVLVTELMTSGTLKTYL+RF+ MKP+VL+ W RQIL+GL FLH+R PP
Sbjct: 259 DFWESSAKGKRCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLLFLHTRTPP 318
Query: 298 ILHRDLKCDNVFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDEAVD 357
I+HRDLKCDN+FITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEE YDE+VD
Sbjct: 319 IIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEHYDESVD 378
Query: 358 VYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEIIEGCIRTDK 417
VYAFGMCMLEMATSEYPYSECQNAAQIYRKVT G KP SF KV PE+KEII CI +K
Sbjct: 379 VYAFGMCMLEMATSEYPYSECQNAAQIYRKVTCGIKPASFEKVHDPEIKEIIGECICKNK 438
Query: 418 NERFTIQDLLAHAFFREERGVHVELAEEDDGEKPGLKLWLRMEDARR-GGRPRDNQAIEF 476
ER+ I+DLL+HAFF E+ GV VELAEED G K + L L +ED ++ G+P+DN AIEF
Sbjct: 439 EERYEIKDLLSHAFFAEDTGVRVELAEEDHGRKSTIALRLWVEDPKKLKGKPKDNGAIEF 498
Query: 477 LFQLGRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQRKREKLRKARELEALPPE 536
F L ++ +EVAQEM+ G E+D + VA+++R+RVA IQ +RE++ A + +
Sbjct: 499 TFDLEKETPDEVAQEMIESGFFHESDVKIVAKSIRDRVALIQWRRERIWPALQPKEQQDV 558
Query: 537 PGPPPATVPMAP-----------GPPSVFPPEPEEPEADQHQPFLFRHASYSSTTSDCET 585
P A P P G P PPEPEEPEADQH S +S SD
Sbjct: 559 GSPDKARGPPVPLQVQVTYHAQAGQPG--PPEPEEPEADQHLLPPTLPTSATSLASDSTF 616
Query: 586 DGYLSSSGFLD----------------ASDPA---LQPPGGVPSSLAESHLCLPSAFALS 626
D S+ + D A PA PP L +S LPS A
Sbjct: 617 DSGQGSTVYSDSQSSQQSVMLGSLADAAPSPAQCVCSPPVSEGPVLPQS---LPSLGAYQ 673
Query: 627 IPRSGPG 633
P + PG
Sbjct: 674 QPTAAPG 680
Score = 140 bits (352), Expect = 1e-32
Identities = 152/521 (29%), Positives = 209/521 (40%), Gaps = 96/521 (18%)
Query: 542 ATVPMAPGPPSVF--PPEPEE--PEADQHQP-FLFRHASYSSTTSDCETDGYLSSSGFLD 596
A VP P PP+ PP PE P A + P F A+ S++ T ++ L
Sbjct: 1037 AQVPTVPVPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASVQSVPTQ----TATLLP 1092
Query: 597 ASDPALQPPGGVPSSLAESHLCLPSAFALSIPRSGPGSDFSPGDSYA-SDAASG--LSDV 653
++P L G+ S L + + P +SY SD SG LSD
Sbjct: 1093 PANPPLPGGPGIASPCPTVQLTVEPVQEEQASQDKPPGLPQSCESYGGSDVTSGKELSDS 1152
Query: 654 GEGMGQMRRPPGRNLR--------------RRPRSRLRVTSVSDQNDRVVECQLQTHNSK 699
EG R GR R R R RL + +V + D++VECQL+THN K
Sbjct: 1153 CEGAFGGGRLEGRAARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHK 1212
Query: 700 MVTFRFDLDGDSPEEIAAAMVYNEFILPSERDGFLRRIREIIQRVETLLKRDTGPMEAAE 759
MVTF+FDLDGD+P+EIA MV ++FIL +ER+ F+ ++++++ + E +L DT ++
Sbjct: 1213 MVTFKFDLDGDAPDEIATYMVEHDFILQAERETFIEQMKDVMDKAEDMLSEDTDADRGSD 1272
Query: 760 DTLSP-----------------------------------------QEEP---APLPALP 775
SP E P AP + P
Sbjct: 1273 PGTSPPHLSTCGLGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAEHPAPEAPESSPP 1332
Query: 776 VPLPDPSNEELQSS-------TSLEHRSWTAFSTSSSSPGTPLSPGNPFSPGTPISPGPI 828
+PL E Q S +S E S+ A S G PG P +P P SP P+
Sbjct: 1333 LPLSSLPPEASQDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAPSSP-PV 1391
Query: 829 FPI----TSPPCHPSPSPFSPISSQVSSNPSPHPTSSPLPFS---SSTPEFPVPLSQCPW 881
+ +P P P S +SQ +P +S L S + T E P+ +
Sbjct: 1392 TALPQDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVV 1451
Query: 882 SSLPTTSPPTFSPTCSQVTLSSPFFPPCPSTSSFPST------TAAPLLSLASAFSLAVM 935
P T P + T P PP P S T APLL A + +
Sbjct: 1452 GLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAA----VGAV 1507
Query: 936 TVAQSLLSPSPGLLSQSPPAPPSPLPSLPLPPPVAPGGQES 976
++A S L PSP L PP PPS L S PP G +S
Sbjct: 1508 SLATSQL-PSPPLGPTVPPQPPSALESDGEGPPPRVGFVDS 1547
Score = 82.8 bits (203), Expect = 2e-15
Identities = 129/513 (25%), Positives = 194/513 (37%), Gaps = 77/513 (15%)
Query: 754 PMEAAEDTLSPQEEPAPLPALPVPLPDPSNEELQSSTSL-EHRSWTAFSTSSSSPGTPLS 812
P A + S ++ AP LP P P+PS +L + + + S T
Sbjct: 1455 PCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQL 1514
Query: 813 PGNPFSPGTPISPGPIFPITSPPCHPSPSPFSPISSQVSSNPSPHPT---SSPLPFSSST 869
P P P P P P + S P P + S + S T +P SS++
Sbjct: 1515 PSPPLGPTVP--PQPPSALESDGEGPPPR-VGFVDSTIKSLDEKLRTLLYQEHVPTSSAS 1571
Query: 870 PEFPVPLSQCPWSSLPTTSPPTFSPTCSQVTLSSPFFPPCPSTS--------------SF 915
PV + ++ P S C PP P + S
Sbjct: 1572 AGTPVEVGDRDFTLEPLRGDQPRSEVCG----GDLALPPVPKEAVSGRVQLPQPLVEKSE 1627
Query: 916 PSTTAAPLLSLASAFSLAVMTVAQSLLS-----PSPGLLSQSPPAPPSPLPSLPLPPPVA 970
+ T ++ ++ S+ + +S+L S P+ P +P+ P V
Sbjct: 1628 LAPTRGAVMEQGTSSSMTAESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAFVRPARVE 1687
Query: 971 P----GGQ------ESPSPHTAEVESEASPPP---ARPLPGEARLAPISEE--GKPQLVG 1015
P GG+ E P V +AS P AR L G R P ++ + VG
Sbjct: 1688 PTDRDGGEAGESSAEPPPSDMGTVGGQASHPQTLGARAL-GSPRKRPEQQDVSSPAKTVG 1746
Query: 1016 RFQVTSSKEP---AEPLPLQPTSPT---LSGSPKPSTPQLTSESSDT------------- 1056
RF V S+++ A P L+ ++P L +P +L + T
Sbjct: 1747 RFSVVSTQDEWTLASPHSLRYSAPPDVYLDEAPSSPDVKLAVRRAQTASSIEVGVGEPVS 1806
Query: 1057 EDSAGGGPETREALA-ESDRAAEGLGAG--VEEEGDDGKEPQVGGSPQPLSHPSPVWMNY 1113
DS GP R + ++ G AG V++ + P GS P + PS V M
Sbjct: 1807 SDSGDEGPRARPPVQKQASLPVSGSVAGDFVKKATAFLQRPSRAGSLGPET-PSRVGMKV 1865
Query: 1114 S-------YSSLCLSSEESESSGEDEEFWAELQSLRQKHLSEVETLQTLQKKEIEDLYSR 1166
+S S +++S ED + ELQSLR+KHL E+ LQ+ QK+EIE LY R
Sbjct: 1866 PTISVTSFHSQSSYISSDNDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRR 1925
Query: 1167 LGKQPPPGI-VAPAAMLSSRQRRLSKGSFPTSR 1198
LGK PP + A + R+R+ SK +
Sbjct: 1926 LGKPLPPNVGFFHTAPPTGRRRKTSKSKLKAGK 1958
Score = 63.9 bits (154), Expect = 9e-10
Identities = 101/376 (26%), Positives = 142/376 (37%), Gaps = 81/376 (21%)
Query: 701 VTFRFDLDGDSPEEIAAAMVYNEFILPSERDGFLRRIREIIQRVETLLKRDTGPMEAAE- 759
+ F FDL+ ++P+E+A M+ + F S+ + IR+ + ++ +R ++ E
Sbjct: 496 IEFTFDLEKETPDEVAQEMIESGFFHESDVKIVAKSIRDRVALIQWRRERIWPALQPKEQ 555
Query: 760 -DTLSPQEEPAPLPALPVPL---------------PDPSNEELQ----------SSTSLE 793
D SP + P PVPL P+P E S+TSL
Sbjct: 556 QDVGSPDKARGP----PVPLQVQVTYHAQAGQPGPPEPEEPEADQHLLPPTLPTSATSLA 611
Query: 794 HRSW-------TAFSTSSSSPGT----PLSPGNPFSP-----GTPISPGPIFPITSPPCH 837
S T +S S SS + L+ P SP P+S GP+ P + P
Sbjct: 612 SDSTFDSGQGSTVYSDSQSSQQSVMLGSLADAAP-SPAQCVCSPPVSEGPVLPQSLPSLG 670
Query: 838 PSPSPFSPISSQVSSNPSPHPTSS-----PLPFSSSTPEFPVPLSQCPWS----SLPTTS 888
P + V S P+P S P P S P P P + P + P
Sbjct: 671 AYQQPTAAPGLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTGPGQPAPPGQQ 730
Query: 889 PPTFS-PT-CSQVTLSSPFFPPCPSTSSFPSTTAAPLLSLASAFSLAVMTVAQSLLSPSP 946
PP + PT QV P P P P AP + + L + + Q+ L P
Sbjct: 731 PPPLAQPTPLPQVLAPQPVVPLQPVPPHLP-PYLAPASQVGAPAQLKPLQMPQAPLQPLA 789
Query: 947 GLLSQSPPAP--------------PSPLPSLPLP--PPVAPGGQESPSPHTAEVESEASP 990
+ Q PP P P LP LP PPV P SP+ + S A+P
Sbjct: 790 QVPPQMPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPA---VILPSLAAP 846
Query: 991 -PPARP-LPGEARLAP 1004
PPA P LP +A P
Sbjct: 847 LPPASPALPLQAVKLP 862
Score = 56.6 bits (135), Expect = 1e-07
Identities = 85/333 (25%), Positives = 119/333 (35%), Gaps = 50/333 (15%)
Query: 762 LSPQEEPAPLPALPVPLPDPSNEELQSSTSLEHRSWTAFSTSSSSPGTP-LSPGNPFS-- 818
L P PL A+ +P P + + T + + T + + PG LS + +
Sbjct: 847 LPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQL 906
Query: 819 PGTPISPGPIFPITSPPCHPSPSPFSPISSQVSSNPSP----HPTSSP---LPFSSSTPE 871
PG P+ P FP +P P PSP + + ++ P P PT P LP + P
Sbjct: 907 PGQPVYPAA-FPQMAPTDVP-PSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPP 964
Query: 872 FPVPLSQCPWSSLPTTSP-------PTFSPTCSQVTLSSPFFPPCPSTSSFPSTTAAPLL 924
PV Q P P P P + P P P ++ P+ T +
Sbjct: 965 QPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAA-PAATPGSQI 1023
Query: 925 SLASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPSPLPSLPLPPPVAPGGQESPSPHTAEV 984
L AV AQ P P SPP P LP+ P P P + S V
Sbjct: 1024 LLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASVQSV 1083
Query: 985 ESEAS---PPPARPLPGEARLA-----------PISEEGKPQLVGRFQVTSSKEPAEPLP 1030
++ + PP PLPG +A P+ EE Q + K P P
Sbjct: 1084 PTQTATLLPPANPPLPGGPGIASPCPTVQLTVEPVQEE---------QASQDKPPGLP-- 1132
Query: 1031 LQPTSPTLSGSPKPSTPQLTSESSDTEDSAGGG 1063
+ + GS S +L S E + GGG
Sbjct: 1133 --QSCESYGGSDVTSGKEL---SDSCEGAFGGG 1160
Score = 41.2 bits (95), Expect = 0.006
Identities = 39/122 (31%), Positives = 54/122 (44%), Gaps = 25/122 (20%)
Query: 980 HTAEVESEASPP-PARPLPGEARL--AP----ISEEGKPQLVGRFQVTSSKEP-----AE 1027
H A E+SPP P LP EA AP +S + +P + Q+ S P A
Sbjct: 1321 HPAPEAPESSPPLPLSSLPPEASQDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAP 1380
Query: 1028 PLPLQPTSPTLSGSPK----PSTPQLTSESSDTEDSAGGGP---------ETREALAESD 1074
P PL P+SP ++ P+ P+T + +S T AGG ET + LAE+
Sbjct: 1381 PAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETH 1440
Query: 1075 RA 1076
A
Sbjct: 1441 EA 1442
Score = 39.7 bits (91), Expect = 0.018
Identities = 41/141 (29%), Positives = 53/141 (37%), Gaps = 15/141 (10%)
Query: 750 RDTGPMEAAEDTLSPQEEPAPLPALPVPLPDPSNEELQ----------SSTSLEHRSWTA 799
R P+ + L PQ P PALPV P+P L S L H + A
Sbjct: 974 RPPQPVLPPQPMLPPQPVLPPQPALPV-RPEPLQPHLPEQAAPAATPGSQILLGHPAPYA 1032
Query: 800 FSTSSSSPGTPLSPGNPFSPGTPISPGPIFPITSPPCHPSPSPFSPISSQVSSNPSPHPT 859
++ P P+ P SP P P P P PS + +S+ V S P+ T
Sbjct: 1033 VDVAAQVPTVPVPPAAVLSPPLPEVLLPAAPELLP---QFPSSLATVSASVQSVPTQTAT 1089
Query: 860 SSPLPFSSSTPEFPVPLSQCP 880
P P + P P S CP
Sbjct: 1090 LLP-PANPPLPGGPGIASPCP 1109
Score = 33.1 bits (74), Expect = 1.7
Identities = 31/100 (31%), Positives = 41/100 (41%), Gaps = 15/100 (15%)
Query: 763 SPQEEPAPLPALPVPLPDPSNEELQSSTSLEHRSWTAFSTSSSSPGTPLSP------GNP 816
S QEEP L A P P P + LQ L + T + + G P +P P
Sbjct: 49 SDQEEPPGLEAAEAPGPQPP-QPLQRRVLLLCK--TRRLIAERARGRPAAPAPAALVAQP 105
Query: 817 FSPGTPISPGPIFPITSPPCHPSPSPFSPISSQVSSNPSP 856
+PG P GP P P P PI++ V + P+P
Sbjct: 106 GAPGAPADAGP-----EPVGTQEPGP-DPIAAAVETAPAP 139
Score = 32.3 bits (72), Expect = 2.9
Identities = 25/78 (32%), Positives = 34/78 (43%), Gaps = 11/78 (14%)
Query: 78 SPAPDPPDPPDSAGPG----PARSPPPSSKEPPEGTWTEGAPVKAAEDSARPELPD---- 129
+P PP P GPG P + PPP ++ P PV + P LP
Sbjct: 707 APVLPPPSTPMPTGPGQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQ-PVPPHLPPYLAP 765
Query: 130 -SAVG-PGSREPLRVPEA 145
S VG P +PL++P+A
Sbjct: 766 ASQVGAPAQLKPLQMPQA 783
Score = 31.2 bits (69), Expect = 6.4
Identities = 21/73 (28%), Positives = 29/73 (39%), Gaps = 9/73 (12%)
Query: 498 VCEADYQPVARAVRERVAAIQRKREKLRKARELEALPPEPG-PPPATVPMAP-------- 548
V + QPV A ++A + + A PP+P PP T+P P
Sbjct: 903 VAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTL 962
Query: 549 GPPSVFPPEPEEP 561
P V PP+P P
Sbjct: 963 PPQPVLPPQPTRP 975
>gi|50845418 WNK lysine deficient protein kinase 3 isoform 1 [Homo
sapiens]
Length = 1800
Score = 560 bits (1443), Expect = e-159
Identities = 306/514 (59%), Positives = 369/514 (71%), Gaps = 26/514 (5%)
Query: 149 ERRREQEEKEDMETQAVATSPDGRYLKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTR 208
+ + E+E +E+ E +AVATSP GR+LKFDIE+GRG+FKTVY+GLDT+T VEVAWCELQ R
Sbjct: 122 KEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDR 181
Query: 209 KLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRR 268
KL++AE+QRF EE EMLKGLQHPNIVRFYDSW+S+L+G+ CIVLVTELMTSGTLKTYL+R
Sbjct: 182 KLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR 241
Query: 269 FREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATLK 328
F+ MKP+VL+ W RQIL+GL FLH+R PPI+HRDLKCDN+FITGPTGSVKIGDLGLATL
Sbjct: 242 FKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLM 301
Query: 329 RASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKV 388
R SFAKSVIGTPEFMAPEMYEE YDE+VDVYAFGMCMLEMATSEYPYSECQNAAQIYRKV
Sbjct: 302 RTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKV 361
Query: 389 TSGRKPNSFHKVKIPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREERGVHVELAEEDDG 448
TSG KP SF+KV PEVKEIIEGCIR +K+ER +I+DLL HAFF E+ G+ VELAEEDD
Sbjct: 362 TSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDDC 421
Query: 449 EKPGLKLWLRMEDARR-GGRPRDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVA 507
L L L +ED ++ G+ +DN+AIEF F L D EEVA EMV G E+D + VA
Sbjct: 422 SNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAVA 481
Query: 508 RAVRERVAAIQRKREK-----LRKARELEALPPE---PGPPPATVPMAPGPPSVFPPEPE 559
+++R+RV I++ REK L + R+ + P P T+P+AP + E E
Sbjct: 482 KSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQT--GAECE 539
Query: 560 EPEADQH--QPFLFRHASY--SSTTSDCETDGYLSSSGFLDASDPALQPPGGVPSSLAES 615
E E DQH Q L R SS T D ++ +S D S PS S
Sbjct: 540 ETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQ--------PSVAYSS 591
Query: 616 HLCLPSAFALSIPRSGPGSDFSPGDSYASDAASG 649
+ + S +IP++ PG Y+S G
Sbjct: 592 NQTMGSQMVSNIPQAEVN---VPGQIYSSQQLVG 622
Score = 94.7 bits (234), Expect = 5e-19
Identities = 99/366 (27%), Positives = 145/366 (39%), Gaps = 57/366 (15%)
Query: 675 RLRVTSVSDQNDRVVECQLQTHNSKMVTFRFDLDGDSPEEIAAAMVYNEFILPSERDGFL 734
+L V VS D +VECQL+THN+KMVTF+FD+DGD+PE+IA MV + F+L SE++ F+
Sbjct: 745 QLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFV 804
Query: 735 RRIREIIQRVETLL------KRDTGPMEAAEDTLSPQEEPAPLPALPVPLPDPSNE---- 784
+R I+ + + +L +R TG D+ S Q + + SNE
Sbjct: 805 EELRAIVGQAQEILHVHFATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQ 864
Query: 785 ------------------ELQSSTSLEHRSWTAFSTSSSSPGTPLSPGNPFSPGTPISPG 826
E QS SL+H + S+ PG P + IS
Sbjct: 865 SSPVGRWRFCINQTIRNRETQSPPSLQH-------SMSAVPGRHPLPSPKNTSNKEISRD 917
Query: 827 PIFPITSPPCH----PSPSPFSPISSQVSSNPSPHPTSSPLPFSSSTPEFPVPLSQCPWS 882
+ I + PCH S S + S + T P + S
Sbjct: 918 TLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAILYQVEDNRQIMAPVTNSS 977
Query: 883 SLPTTSPPTFSPTCSQVT-LSSPFFP--PCPSTSS-----------FPSTTAAPLLSLAS 928
S TTS C +T +S F P PC T+S T+ L +LA
Sbjct: 978 SYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSHPGESTQTSGNSLTTLAF 1037
Query: 929 AFSLAVMTVAQSLLSPSPGLLSQSPPAPPSPLPSLP--LPPPVAPGGQESPSPHTAEVES 986
++V Q + +SQ + S P + P PG + + T +ES
Sbjct: 1038 DQKPQTLSVQQPAMDAE--FISQEGETTVNTEASSPKTVIPTQTPGLEPTTLQPTTVLES 1095
Query: 987 EASPPP 992
+ PP
Sbjct: 1096 DGERPP 1101
Score = 54.7 bits (130), Expect = 5e-07
Identities = 44/148 (29%), Positives = 64/148 (43%), Gaps = 19/148 (12%)
Query: 1037 TLSGSPKPSTPQLTSESSDTEDSA-GGGPETREALAESDRAAEGLGAGVEEEGDDGKEPQ 1095
+ S + + +T E E SA G ++ L +R E L AG + D
Sbjct: 1421 SFSAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKER--EILTAGKQPSSDSEFSAS 1478
Query: 1096 VGGSPQPLSHPSP----------------VWMNYSYSSLCLSSEESESSGEDEEFWAELQ 1139
+ GS + ++ P + YS S + ES EDE+ ELQ
Sbjct: 1479 LAGSGKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQ 1538
Query: 1140 SLRQKHLSEVETLQTLQKKEIEDLYSRL 1167
LR+KH+ EV LQT Q KE+++LY RL
Sbjct: 1539 RLREKHIQEVVNLQTQQNKELQELYERL 1566
Score = 38.9 bits (89), Expect = 0.031
Identities = 26/99 (26%), Positives = 47/99 (47%), Gaps = 8/99 (8%)
Query: 697 NSKMVTFRFDLDGDSPEEIAAAMVYNEFILPSERDGFLRRIREIIQRV-ETLLKRDTGPM 755
+++ + F F+L+ D+PEE+A MV + F S+ + IR+ + + +T K+ G +
Sbjct: 444 DNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCL 503
Query: 756 EAAEDT-------LSPQEEPAPLPALPVPLPDPSNEELQ 787
E D+ + PQ + LP P EE +
Sbjct: 504 EERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEETE 542
>gi|50845416 WNK lysine deficient protein kinase 3 isoform 2 [Homo
sapiens]
Length = 1743
Score = 560 bits (1443), Expect = e-159
Identities = 306/514 (59%), Positives = 369/514 (71%), Gaps = 26/514 (5%)
Query: 149 ERRREQEEKEDMETQAVATSPDGRYLKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTR 208
+ + E+E +E+ E +AVATSP GR+LKFDIE+GRG+FKTVY+GLDT+T VEVAWCELQ R
Sbjct: 122 KEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDR 181
Query: 209 KLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRR 268
KL++AE+QRF EE EMLKGLQHPNIVRFYDSW+S+L+G+ CIVLVTELMTSGTLKTYL+R
Sbjct: 182 KLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR 241
Query: 269 FREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATLK 328
F+ MKP+VL+ W RQIL+GL FLH+R PPI+HRDLKCDN+FITGPTGSVKIGDLGLATL
Sbjct: 242 FKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLM 301
Query: 329 RASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKV 388
R SFAKSVIGTPEFMAPEMYEE YDE+VDVYAFGMCMLEMATSEYPYSECQNAAQIYRKV
Sbjct: 302 RTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKV 361
Query: 389 TSGRKPNSFHKVKIPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREERGVHVELAEEDDG 448
TSG KP SF+KV PEVKEIIEGCIR +K+ER +I+DLL HAFF E+ G+ VELAEEDD
Sbjct: 362 TSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDDC 421
Query: 449 EKPGLKLWLRMEDARR-GGRPRDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVA 507
L L L +ED ++ G+ +DN+AIEF F L D EEVA EMV G E+D + VA
Sbjct: 422 SNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAVA 481
Query: 508 RAVRERVAAIQRKREK-----LRKARELEALPPE---PGPPPATVPMAPGPPSVFPPEPE 559
+++R+RV I++ REK L + R+ + P P T+P+AP + E E
Sbjct: 482 KSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQT--GAECE 539
Query: 560 EPEADQH--QPFLFRHASY--SSTTSDCETDGYLSSSGFLDASDPALQPPGGVPSSLAES 615
E E DQH Q L R SS T D ++ +S D S PS S
Sbjct: 540 ETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQ--------PSVAYSS 591
Query: 616 HLCLPSAFALSIPRSGPGSDFSPGDSYASDAASG 649
+ + S +IP++ PG Y+S G
Sbjct: 592 NQTMGSQMVSNIPQAEVN---VPGQIYSSQQLVG 622
Score = 94.7 bits (234), Expect = 5e-19
Identities = 99/366 (27%), Positives = 145/366 (39%), Gaps = 57/366 (15%)
Query: 675 RLRVTSVSDQNDRVVECQLQTHNSKMVTFRFDLDGDSPEEIAAAMVYNEFILPSERDGFL 734
+L V VS D +VECQL+THN+KMVTF+FD+DGD+PE+IA MV + F+L SE++ F+
Sbjct: 745 QLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFV 804
Query: 735 RRIREIIQRVETLL------KRDTGPMEAAEDTLSPQEEPAPLPALPVPLPDPSNE---- 784
+R I+ + + +L +R TG D+ S Q + + SNE
Sbjct: 805 EELRAIVGQAQEILHVHFATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQ 864
Query: 785 ------------------ELQSSTSLEHRSWTAFSTSSSSPGTPLSPGNPFSPGTPISPG 826
E QS SL+H + S+ PG P + IS
Sbjct: 865 SSPVGRWRFCINQTIRNRETQSPPSLQH-------SMSAVPGRHPLPSPKNTSNKEISRD 917
Query: 827 PIFPITSPPCH----PSPSPFSPISSQVSSNPSPHPTSSPLPFSSSTPEFPVPLSQCPWS 882
+ I + PCH S S + S + T P + S
Sbjct: 918 TLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAILYQVEDNRQIMAPVTNSS 977
Query: 883 SLPTTSPPTFSPTCSQVT-LSSPFFP--PCPSTSS-----------FPSTTAAPLLSLAS 928
S TTS C +T +S F P PC T+S T+ L +LA
Sbjct: 978 SYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSHPGESTQTSGNSLTTLAF 1037
Query: 929 AFSLAVMTVAQSLLSPSPGLLSQSPPAPPSPLPSLP--LPPPVAPGGQESPSPHTAEVES 986
++V Q + +SQ + S P + P PG + + T +ES
Sbjct: 1038 DQKPQTLSVQQPAMDAE--FISQEGETTVNTEASSPKTVIPTQTPGLEPTTLQPTTVLES 1095
Query: 987 EASPPP 992
+ PP
Sbjct: 1096 DGERPP 1101
Score = 58.2 bits (139), Expect = 5e-08
Identities = 64/231 (27%), Positives = 95/231 (41%), Gaps = 32/231 (13%)
Query: 1037 TLSGSPKPSTPQLTSESSDTEDSA-GGGPETREALAESDRAAEGLGAGVEEEGDDGKEPQ 1095
+ S + + +T E E SA G ++ L +R E L AG + D
Sbjct: 1374 SFSAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKER--EILTAGKQPSSDSEFSAS 1431
Query: 1096 VGGSPQPLSHPSP----------------VWMNYSYSSLCLSSEESESSGEDEEFWAELQ 1139
+ GS + ++ P + YS S + ES EDE+ ELQ
Sbjct: 1432 LAGSGKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQ 1491
Query: 1140 SLRQKHLSEVETLQTLQKKEIEDLYSRL-----GKQPPPGIVAPAAMLSSRQRRLSKGSF 1194
LR+KH+ EV LQT Q KE+++LY RL K I P A S R+ R SF
Sbjct: 1492 RLREKHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPA--SPRRPR----SF 1545
Query: 1195 PTSRRNSLQRSEPPGPGIMRRNSL--SGSSTGSQEQRASKGVTFAGDVGRM 1243
+ R+ Q GI+ + L ++ Q+ ASK F D+ ++
Sbjct: 1546 KSKLRSRPQSLTHVDNGIVATDPLCVESNAASCQQSPASKKGMFTDDLHKL 1596
Score = 38.9 bits (89), Expect = 0.031
Identities = 26/99 (26%), Positives = 47/99 (47%), Gaps = 8/99 (8%)
Query: 697 NSKMVTFRFDLDGDSPEEIAAAMVYNEFILPSERDGFLRRIREIIQRV-ETLLKRDTGPM 755
+++ + F F+L+ D+PEE+A MV + F S+ + IR+ + + +T K+ G +
Sbjct: 444 DNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCL 503
Query: 756 EAAEDT-------LSPQEEPAPLPALPVPLPDPSNEELQ 787
E D+ + PQ + LP P EE +
Sbjct: 504 EERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEETE 542
>gi|7019333 nuclear receptor binding protein [Homo sapiens]
Length = 535
Score = 145 bits (365), Expect = 3e-34
Identities = 129/488 (26%), Positives = 210/488 (43%), Gaps = 67/488 (13%)
Query: 111 TEGAPVKAAEDSARPELPDSAVGPGSREPLRVPEAVALERRREQEEKEDMETQAVATSPD 170
+EG + P++ S+ PG + E+EE+ + E++ + SP
Sbjct: 2 SEGESQTVLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEESPC 61
Query: 171 GRYLKFDIEIGRGS---FKTVYRGLDTDTTVEVAWCELQ--TRKLSRAERQRFSEEVEML 225
GR+ K E+ + + + Y +DT+ VEV W E+Q RK + + ++ + L
Sbjct: 62 GRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNL 121
Query: 226 KGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFRE----MKPRVLQRWS 281
L+H NIV+F+ W + + ++ +TE M+SG+LK +L++ ++ M + +RW
Sbjct: 122 IQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWC 181
Query: 282 RQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATL-KRASFAKSVIGTP 340
QIL L +LHS PPI+H +L CD +FI G +KIG + T+ +
Sbjct: 182 TQILSALSYLHSCDPPIIHGNLTCDTIFIQ-HNGLIKIGSVAPDTINNHVKTCREEQKNL 240
Query: 341 EFMAPEMYE-EKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHK 399
F APE E AVD+Y+FGMC LEMA E N Y V ++
Sbjct: 241 HFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQ----GNGESSY--VPQEAISSAIQL 294
Query: 400 VKIPEVKEIIEGCIRTDKNERFTIQDLLAH-AFFREERGVHVELAEEDDGEKPGLKLWLR 458
++ P +E I+ C++++ R T ++LL H A F E P LKL
Sbjct: 295 LEDPLQREFIQKCLQSEPARRPTARELLFHPALF----------------EVPSLKLLAA 338
Query: 459 MEDARRGGRPRDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQ 518
+ + + +A EE+ + M ++ E P RE V +
Sbjct: 339 ------------HCIVGHQHMIPENALEEITKNMDTSAVLAEIPAGP----GREPVQTLY 382
Query: 519 RKREKLRKARELEAL--------------PPEPGPPPATVPMAPGPPSVFPPEPEEPEAD 564
+ L + LE + P +P T P+ PPSV P PE E +
Sbjct: 383 SQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVV--PPSVKTPTPEPAEVE 440
Query: 565 QHQPFLFR 572
+ L +
Sbjct: 441 TRKVVLMQ 448
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 119 bits (297), Expect = 2e-26
Identities = 82/270 (30%), Positives = 137/270 (50%), Gaps = 19/270 (7%)
Query: 180 IGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDS 239
+G+GS+ V + +L R S ER+ +E ++L L+HPNIV + +S
Sbjct: 12 VGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKES 71
Query: 240 WKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQ-----RWSRQILRGLHFLHSR 294
W+ G + +V G L R+ +E K ++L W QI L +LH +
Sbjct: 72 WEG---GDGLLYIVMGFCEGGDL---YRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK 125
Query: 295 VPPILHRDLKCDNVFITGPTGSVKIGDLGLATL--KRASFAKSVIGTPEFMAPEMYEEK- 351
ILHRDLK NVF+T T +K+GDLG+A + A ++IGTP +M+PE++ K
Sbjct: 126 --HILHRDLKTQNVFLT-RTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKP 182
Query: 352 YDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEIIEG 411
Y+ DV+A G C+ EMAT ++ ++ + +YR + G+ P + PE+ E+I
Sbjct: 183 YNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYR-IIEGKLP-PMPRDYSPELAELIRT 240
Query: 412 CIRTDKNERFTIQDLLAHAFFREERGVHVE 441
+ ER +++ +L + + + +E
Sbjct: 241 MLSKRPEERPSVRSILRQPYIKRQISFFLE 270
>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
Length = 302
Score = 116 bits (290), Expect = 2e-25
Identities = 86/269 (31%), Positives = 142/269 (52%), Gaps = 21/269 (7%)
Query: 166 ATSPDGRY-----LKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAE-RQRFS 219
A PD Y + + +IGRG F VYR V VA ++Q L A+ R
Sbjct: 21 ALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCI 80
Query: 220 EEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMK----PR 275
+E+++LK L HPN++++Y S+ + ++ IVL EL +G L ++ F++ K R
Sbjct: 81 KEIDLLKQLNHPNVIKYYASF--IEDNELNIVL--ELADAGDLSRMIKHFKKQKRLIPER 136
Query: 276 VLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATL--KRASFA 333
+ ++ Q+ L +HSR ++HRD+K NVFIT TG VK+GDLGL + + A
Sbjct: 137 TVWKYFVQLCSALEHMHSR--RVMHRDIKPANVFITA-TGVVKLGDLGLGRFFSSKTTAA 193
Query: 334 KSVIGTPEFMAPE-MYEEKYDEAVDVYAFGMCMLEMATSEYP-YSECQNAAQIYRKVTSG 391
S++GTP +M+PE ++E Y+ D+++ G + EMA + P Y + N + +K+
Sbjct: 194 HSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQC 253
Query: 392 RKPNSFHKVKIPEVKEIIEGCIRTDKNER 420
P E+++++ CI D +R
Sbjct: 254 DYPPLPSDHYSEELRQLVNMCINPDPEKR 282
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 114 bits (285), Expect = 6e-25
Identities = 101/382 (26%), Positives = 182/382 (47%), Gaps = 25/382 (6%)
Query: 63 SSVDLGLLSSWSLPASP--APDPPDPPDSAGPGPARSPPPS-SKEPPEGTWTEGAPVKAA 119
SS L + + PA P + D D D A P P +P P +K + E PV
Sbjct: 155 SSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPT 214
Query: 120 EDSARPELPDSAVGPGSREPLRVPEAVALERRR----EQEEKEDMETQAVATSPDGRYLK 175
D A P S + P + ++++ ++E E + + P +Y +
Sbjct: 215 RDVATS--PISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTR 272
Query: 176 FDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVR 235
F+ +IG+G+ TVY +D T EVA ++ ++ + +++ E+ +++ ++PNIV
Sbjct: 273 FE-KIGQGASGTVYTAMDVATGQEVAIKQMNLQQ--QPKKELIINEILVMRENKNPNIVN 329
Query: 236 FYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRV 295
+ DS+ ++ ++ +V+ E + G+L + M + R+ L+ L FLHS
Sbjct: 330 YLDSY--LVGDELWVVM--EYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEFLHSN- 383
Query: 296 PPILHRDLKCDNVFITGPTGSVKIGDLGLAT--LKRASFAKSVIGTPEFMAPEMYEEK-Y 352
++HRD+K DN+ + G GSVK+ D G S +++GTP +MAPE+ K Y
Sbjct: 384 -QVIHRDIKSDNILL-GMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY 441
Query: 353 DEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEV-KEIIEG 411
VD+++ G+ +EM E PY +Y T+G P + K+ + ++ +
Sbjct: 442 GPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG-TPELQNPEKLSAIFRDFLNR 500
Query: 412 CIRTDKNERFTIQDLLAHAFFR 433
C+ D +R + ++LL H F +
Sbjct: 501 CLEMDVEKRGSAKELLQHQFLK 522
>gi|55956904 mitogen-activated protein kinase kinase kinase 4 isoform
a [Homo sapiens]
Length = 1608
Score = 113 bits (283), Expect = 1e-24
Identities = 76/265 (28%), Positives = 140/265 (52%), Gaps = 20/265 (7%)
Query: 179 EIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYD 238
+IG G + VY + DT +A E++ + + ++E+++ +G++HPN+VR++
Sbjct: 1348 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFG 1407
Query: 239 SWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPI 298
+ R ++ I + E GTL+ R ++ V++ +S+QI ++ LH I
Sbjct: 1408 --VELHREEMYIFM--EYCDEGTLEEVSR--LGLQEHVIRLYSKQITIAINVLHEH--GI 1459
Query: 299 LHRDLKCDNVFITGPTGSVKIGDLGLATLKRASF------AKSVIGTPEFMAPEMYE--- 349
+HRD+K N+F+T +G +K+GD G + + + S +GT +MAPE+
Sbjct: 1460 VHRDIKGANIFLTS-SGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAK 1518
Query: 350 -EKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEI 408
E + A D+++ G ++EM T + P+ E ++ QI KV G KP ++ PE K+
Sbjct: 1519 GEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLS-PEGKDF 1577
Query: 409 IEGCIRTDKNERFTIQDLLAHAFFR 433
+ C+ +D R+T LL H+F +
Sbjct: 1578 LSHCLESDPKMRWTASQLLDHSFVK 1602
>gi|55956902 mitogen-activated protein kinase kinase kinase 4 isoform
b [Homo sapiens]
Length = 1558
Score = 113 bits (283), Expect = 1e-24
Identities = 76/265 (28%), Positives = 140/265 (52%), Gaps = 20/265 (7%)
Query: 179 EIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYD 238
+IG G + VY + DT +A E++ + + ++E+++ +G++HPN+VR++
Sbjct: 1298 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFG 1357
Query: 239 SWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPI 298
+ R ++ I + E GTL+ R ++ V++ +S+QI ++ LH I
Sbjct: 1358 --VELHREEMYIFM--EYCDEGTLEEVSR--LGLQEHVIRLYSKQITIAINVLHEH--GI 1409
Query: 299 LHRDLKCDNVFITGPTGSVKIGDLGLATLKRASF------AKSVIGTPEFMAPEMYE--- 349
+HRD+K N+F+T +G +K+GD G + + + S +GT +MAPE+
Sbjct: 1410 VHRDIKGANIFLTS-SGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAK 1468
Query: 350 -EKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEI 408
E + A D+++ G ++EM T + P+ E ++ QI KV G KP ++ PE K+
Sbjct: 1469 GEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLS-PEGKDF 1527
Query: 409 IEGCIRTDKNERFTIQDLLAHAFFR 433
+ C+ +D R+T LL H+F +
Sbjct: 1528 LSHCLESDPKMRWTASQLLDHSFVK 1552
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 113 bits (282), Expect = 1e-24
Identities = 96/369 (26%), Positives = 171/369 (46%), Gaps = 24/369 (6%)
Query: 76 PASPAPDPPDPPDSAGPGPARSPPPSSKEPPEGTWTEGAPVKAAEDSARPELPDSAVGPG 135
P +P + + PPP PE T + E A P +P+ V P
Sbjct: 180 PLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTR-SVVESIASPAVPNKEVTPP 238
Query: 136 SREPLRVPEAVALERRREQEEK-------EDMETQAVATSPDGRYLKFDIEIGRGSFKTV 188
S E R+ ++ K E + + P +Y +F+ +IG+G+ TV
Sbjct: 239 SAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE-KIGQGASGTV 297
Query: 189 YRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQV 248
Y LD T EVA ++ ++ + +++ E+ +++ ++PNIV + DS+ ++ ++
Sbjct: 298 YTALDIATGQEVAIKQMNLQQ--QPKKELIINEILVMRENKNPNIVNYLDSY--LVGDEL 353
Query: 249 CIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNV 308
+V+ E + G+L + M + R+ L+ L FLHS ++HRD+K DN+
Sbjct: 354 WVVM--EYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSN--QVIHRDIKSDNI 408
Query: 309 FITGPTGSVKIGDLGLAT--LKRASFAKSVIGTPEFMAPEMYEEK-YDEAVDVYAFGMCM 365
+ G GSVK+ D G S +++GTP +MAPE+ K Y VD+++ G+
Sbjct: 409 LL-GMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 467
Query: 366 LEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEV-KEIIEGCIRTDKNERFTIQ 424
+EM E PY +Y T+G P + ++ V ++ + C+ D + R + +
Sbjct: 468 IEMVEGEPPYLNENPLRALYLIATNG-TPELQNPERLSAVFRDFLNRCLEMDVDRRGSAK 526
Query: 425 DLLAHAFFR 433
+LL H F +
Sbjct: 527 ELLQHPFLK 535
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 113 bits (282), Expect = 1e-24
Identities = 96/369 (26%), Positives = 171/369 (46%), Gaps = 24/369 (6%)
Query: 76 PASPAPDPPDPPDSAGPGPARSPPPSSKEPPEGTWTEGAPVKAAEDSARPELPDSAVGPG 135
P +P + + PPP PE T + E A P +P+ V P
Sbjct: 186 PLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTR-SVVESIASPAVPNKEVTPP 244
Query: 136 SREPLRVPEAVALERRREQEEK-------EDMETQAVATSPDGRYLKFDIEIGRGSFKTV 188
S E R+ ++ K E + + P +Y +F+ +IG+G+ TV
Sbjct: 245 SAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE-KIGQGASGTV 303
Query: 189 YRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQV 248
Y LD T EVA ++ ++ + +++ E+ +++ ++PNIV + DS+ ++ ++
Sbjct: 304 YTALDIATGQEVAIKQMNLQQ--QPKKELIINEILVMRENKNPNIVNYLDSY--LVGDEL 359
Query: 249 CIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNV 308
+V+ E + G+L + M + R+ L+ L FLHS ++HRD+K DN+
Sbjct: 360 WVVM--EYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSN--QVIHRDIKSDNI 414
Query: 309 FITGPTGSVKIGDLGLAT--LKRASFAKSVIGTPEFMAPEMYEEK-YDEAVDVYAFGMCM 365
+ G GSVK+ D G S +++GTP +MAPE+ K Y VD+++ G+
Sbjct: 415 LL-GMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 473
Query: 366 LEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEV-KEIIEGCIRTDKNERFTIQ 424
+EM E PY +Y T+G P + ++ V ++ + C+ D + R + +
Sbjct: 474 IEMVEGEPPYLNENPLRALYLIATNG-TPELQNPERLSAVFRDFLNRCLEMDVDRRGSAK 532
Query: 425 DLLAHAFFR 433
+LL H F +
Sbjct: 533 ELLQHPFLK 541
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 113 bits (282), Expect = 1e-24
Identities = 96/369 (26%), Positives = 171/369 (46%), Gaps = 24/369 (6%)
Query: 76 PASPAPDPPDPPDSAGPGPARSPPPSSKEPPEGTWTEGAPVKAAEDSARPELPDSAVGPG 135
P +P + + PPP PE T + E A P +P+ V P
Sbjct: 201 PLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTR-SVVESIASPAVPNKEVTPP 259
Query: 136 SREPLRVPEAVALERRREQEEK-------EDMETQAVATSPDGRYLKFDIEIGRGSFKTV 188
S E R+ ++ K E + + P +Y +F+ +IG+G+ TV
Sbjct: 260 SAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE-KIGQGASGTV 318
Query: 189 YRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQV 248
Y LD T EVA ++ ++ + +++ E+ +++ ++PNIV + DS+ ++ ++
Sbjct: 319 YTALDIATGQEVAIKQMNLQQ--QPKKELIINEILVMRENKNPNIVNYLDSY--LVGDEL 374
Query: 249 CIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNV 308
+V+ E + G+L + M + R+ L+ L FLHS ++HRD+K DN+
Sbjct: 375 WVVM--EYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSN--QVIHRDIKSDNI 429
Query: 309 FITGPTGSVKIGDLGLAT--LKRASFAKSVIGTPEFMAPEMYEEK-YDEAVDVYAFGMCM 365
+ G GSVK+ D G S +++GTP +MAPE+ K Y VD+++ G+
Sbjct: 430 LL-GMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 488
Query: 366 LEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEV-KEIIEGCIRTDKNERFTIQ 424
+EM E PY +Y T+G P + ++ V ++ + C+ D + R + +
Sbjct: 489 IEMVEGEPPYLNENPLRALYLIATNG-TPELQNPERLSAVFRDFLNRCLEMDVDRRGSAK 547
Query: 425 DLLAHAFFR 433
+LL H F +
Sbjct: 548 ELLQHPFLK 556
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 113 bits (282), Expect = 1e-24
Identities = 96/369 (26%), Positives = 171/369 (46%), Gaps = 24/369 (6%)
Query: 76 PASPAPDPPDPPDSAGPGPARSPPPSSKEPPEGTWTEGAPVKAAEDSARPELPDSAVGPG 135
P +P + + PPP PE T + E A P +P+ V P
Sbjct: 165 PLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTR-SVVESIASPAVPNKEVTPP 223
Query: 136 SREPLRVPEAVALERRREQEEK-------EDMETQAVATSPDGRYLKFDIEIGRGSFKTV 188
S E R+ ++ K E + + P +Y +F+ +IG+G+ TV
Sbjct: 224 SAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE-KIGQGASGTV 282
Query: 189 YRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQV 248
Y LD T EVA ++ ++ + +++ E+ +++ ++PNIV + DS+ ++ ++
Sbjct: 283 YTALDIATGQEVAIKQMNLQQ--QPKKELIINEILVMRENKNPNIVNYLDSY--LVGDEL 338
Query: 249 CIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNV 308
+V+ E + G+L + M + R+ L+ L FLHS ++HRD+K DN+
Sbjct: 339 WVVM--EYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSN--QVIHRDIKSDNI 393
Query: 309 FITGPTGSVKIGDLGLAT--LKRASFAKSVIGTPEFMAPEMYEEK-YDEAVDVYAFGMCM 365
+ G GSVK+ D G S +++GTP +MAPE+ K Y VD+++ G+
Sbjct: 394 LL-GMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 452
Query: 366 LEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEV-KEIIEGCIRTDKNERFTIQ 424
+EM E PY +Y T+G P + ++ V ++ + C+ D + R + +
Sbjct: 453 IEMVEGEPPYLNENPLRALYLIATNG-TPELQNPERLSAVFRDFLNRCLEMDVDRRGSAK 511
Query: 425 DLLAHAFFR 433
+LL H F +
Sbjct: 512 ELLQHPFLK 520
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 113 bits (282), Expect = 1e-24
Identities = 96/369 (26%), Positives = 171/369 (46%), Gaps = 24/369 (6%)
Query: 76 PASPAPDPPDPPDSAGPGPARSPPPSSKEPPEGTWTEGAPVKAAEDSARPELPDSAVGPG 135
P +P + + PPP PE T + E A P +P+ V P
Sbjct: 165 PLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTR-SVVESIASPAVPNKEVTPP 223
Query: 136 SREPLRVPEAVALERRREQEEK-------EDMETQAVATSPDGRYLKFDIEIGRGSFKTV 188
S E R+ ++ K E + + P +Y +F+ +IG+G+ TV
Sbjct: 224 SAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE-KIGQGASGTV 282
Query: 189 YRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQV 248
Y LD T EVA ++ ++ + +++ E+ +++ ++PNIV + DS+ ++ ++
Sbjct: 283 YTALDIATGQEVAIKQMNLQQ--QPKKELIINEILVMRENKNPNIVNYLDSY--LVGDEL 338
Query: 249 CIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNV 308
+V+ E + G+L + M + R+ L+ L FLHS ++HRD+K DN+
Sbjct: 339 WVVM--EYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSN--QVIHRDIKSDNI 393
Query: 309 FITGPTGSVKIGDLGLAT--LKRASFAKSVIGTPEFMAPEMYEEK-YDEAVDVYAFGMCM 365
+ G GSVK+ D G S +++GTP +MAPE+ K Y VD+++ G+
Sbjct: 394 LL-GMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 452
Query: 366 LEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEV-KEIIEGCIRTDKNERFTIQ 424
+EM E PY +Y T+G P + ++ V ++ + C+ D + R + +
Sbjct: 453 IEMVEGEPPYLNENPLRALYLIATNG-TPELQNPERLSAVFRDFLNRCLEMDVDRRGSAK 511
Query: 425 DLLAHAFFR 433
+LL H F +
Sbjct: 512 ELLQHPFLK 520
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 113 bits (282), Expect = 1e-24
Identities = 96/369 (26%), Positives = 171/369 (46%), Gaps = 24/369 (6%)
Query: 76 PASPAPDPPDPPDSAGPGPARSPPPSSKEPPEGTWTEGAPVKAAEDSARPELPDSAVGPG 135
P +P + + PPP PE T + E A P +P+ V P
Sbjct: 165 PLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTR-SVVESIASPAVPNKEVTPP 223
Query: 136 SREPLRVPEAVALERRREQEEK-------EDMETQAVATSPDGRYLKFDIEIGRGSFKTV 188
S E R+ ++ K E + + P +Y +F+ +IG+G+ TV
Sbjct: 224 SAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFE-KIGQGASGTV 282
Query: 189 YRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQV 248
Y LD T EVA ++ ++ + +++ E+ +++ ++PNIV + DS+ ++ ++
Sbjct: 283 YTALDIATGQEVAIKQMNLQQ--QPKKELIINEILVMRENKNPNIVNYLDSY--LVGDEL 338
Query: 249 CIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNV 308
+V+ E + G+L + M + R+ L+ L FLHS ++HRD+K DN+
Sbjct: 339 WVVM--EYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSN--QVIHRDIKSDNI 393
Query: 309 FITGPTGSVKIGDLGLAT--LKRASFAKSVIGTPEFMAPEMYEEK-YDEAVDVYAFGMCM 365
+ G GSVK+ D G S +++GTP +MAPE+ K Y VD+++ G+
Sbjct: 394 LL-GMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMA 452
Query: 366 LEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEV-KEIIEGCIRTDKNERFTIQ 424
+EM E PY +Y T+G P + ++ V ++ + C+ D + R + +
Sbjct: 453 IEMVEGEPPYLNENPLRALYLIATNG-TPELQNPERLSAVFRDFLNRCLEMDVDRRGSAK 511
Query: 425 DLLAHAFFR 433
+LL H F +
Sbjct: 512 ELLQHPFLK 520
>gi|42794767 mitogen-activated protein kinase kinase kinase 3
isoform 1 [Homo sapiens]
Length = 657
Score = 111 bits (277), Expect = 5e-24
Identities = 81/261 (31%), Positives = 136/261 (52%), Gaps = 16/261 (6%)
Query: 180 IGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSE---EVEMLKGLQHPNIVRF 236
+G+G+F VY D DT E+A ++Q S + S E+++LK LQH IV++
Sbjct: 399 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 458
Query: 237 YDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVP 296
Y + R + + + E M G++K L+ + + V ++++RQIL G+ +LHS +
Sbjct: 459 YGCLRD--RAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNM- 515
Query: 297 PILHRDLKCDNVFITGPTGSVKIGDLG----LATL-KRASFAKSVIGTPEFMAPEMYE-E 350
I+HRD+K N+ + G+VK+GD G L T+ + +SV GTP +M+PE+ E
Sbjct: 516 -IVHRDIKGANI-LRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGE 573
Query: 351 KYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEIIE 410
Y DV++ G ++EM T + P++E + A I++ T P I E
Sbjct: 574 GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQL--PSHISEHGRDFL 631
Query: 411 GCIRTDKNERFTIQDLLAHAF 431
I + +R + ++LL H F
Sbjct: 632 RRIFVEARQRPSAEELLTHHF 652
>gi|42794765 mitogen-activated protein kinase kinase kinase 3
isoform 2 [Homo sapiens]
Length = 626
Score = 111 bits (277), Expect = 5e-24
Identities = 81/261 (31%), Positives = 136/261 (52%), Gaps = 16/261 (6%)
Query: 180 IGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSE---EVEMLKGLQHPNIVRF 236
+G+G+F VY D DT E+A ++Q S + S E+++LK LQH IV++
Sbjct: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
Query: 237 YDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVP 296
Y + R + + + E M G++K L+ + + V ++++RQIL G+ +LHS +
Sbjct: 428 YGCLRD--RAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNM- 484
Query: 297 PILHRDLKCDNVFITGPTGSVKIGDLG----LATL-KRASFAKSVIGTPEFMAPEMYE-E 350
I+HRD+K N+ + G+VK+GD G L T+ + +SV GTP +M+PE+ E
Sbjct: 485 -IVHRDIKGANI-LRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGE 542
Query: 351 KYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEIIE 410
Y DV++ G ++EM T + P++E + A I++ T P I E
Sbjct: 543 GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQL--PSHISEHGRDFL 600
Query: 411 GCIRTDKNERFTIQDLLAHAF 431
I + +R + ++LL H F
Sbjct: 601 RRIFVEARQRPSAEELLTHHF 621
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 110 bits (275), Expect = 8e-24
Identities = 82/284 (28%), Positives = 140/284 (49%), Gaps = 14/284 (4%)
Query: 153 EQEEKEDMETQAVATSPDGRYLKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSR 212
++E E + T P +Y +++ +IG+G+ TV+ D EVA ++ +K +
Sbjct: 229 DEEIMEKLRTIVSIGDPKKKYTRYE-KIGQGASGTVFTATDVALGQEVAIKQINLQK--Q 285
Query: 213 AERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREM 272
+++ E+ ++K L++PNIV F DS+ L G V V E + G+L + M
Sbjct: 286 PKKELIINEILVMKELKNPNIVNFLDSY---LVGDELFV-VMEYLAGGSLTDVVTETC-M 340
Query: 273 KPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLAT--LKRA 330
+ R+ L+ L FLH+ ++HRD+K DNV + G GSVK+ D G
Sbjct: 341 DEAQIAAVCRECLQALEFLHAN--QVIHRDIKSDNVLL-GMEGSVKLTDFGFCAQITPEQ 397
Query: 331 SFAKSVIGTPEFMAPEMYEEK-YDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVT 389
S +++GTP +MAPE+ K Y VD+++ G+ +EM E PY +Y T
Sbjct: 398 SKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIAT 457
Query: 390 SGRKPNSFHKVKIPEVKEIIEGCIRTDKNERFTIQDLLAHAFFR 433
+G + P ++ + C+ D +R + ++LL H F +
Sbjct: 458 NGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLK 501
>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
Length = 347
Score = 110 bits (275), Expect = 8e-24
Identities = 83/256 (32%), Positives = 139/256 (54%), Gaps = 18/256 (7%)
Query: 176 FDIE--IGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAE-RQRFSEEVEMLKGLQHPN 232
F IE IGRG F VY+ VA ++Q ++ A+ RQ +E+ +LK L HPN
Sbjct: 79 FQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPN 138
Query: 233 IVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMK----PRVLQRWSRQILRGL 288
I+++ DS+ + ++ IVL EL +G L ++ F++ K R + ++ Q+ +
Sbjct: 139 IIKYLDSF--IEDNELNIVL--ELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAV 194
Query: 289 HFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATL--KRASFAKSVIGTPEFMAPE 346
+HSR ++HRD+K NVFIT TG VK+GDLGL + A S++GTP +M+PE
Sbjct: 195 EHMHSR--RVMHRDIKPANVFITA-TGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPE 251
Query: 347 -MYEEKYDEAVDVYAFGMCMLEMATSEYP-YSECQNAAQIYRKVTSGRKPNSFHKVKIPE 404
++E Y+ D+++ G + EMA + P Y + N + +K+ P + +
Sbjct: 252 RIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEK 311
Query: 405 VKEIIEGCIRTDKNER 420
++E++ CI D ++R
Sbjct: 312 LRELVSMCICPDPHQR 327
>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
Length = 313
Score = 110 bits (275), Expect = 8e-24
Identities = 83/256 (32%), Positives = 139/256 (54%), Gaps = 18/256 (7%)
Query: 176 FDIE--IGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAE-RQRFSEEVEMLKGLQHPN 232
F IE IGRG F VY+ VA ++Q ++ A+ RQ +E+ +LK L HPN
Sbjct: 45 FQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPN 104
Query: 233 IVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMK----PRVLQRWSRQILRGL 288
I+++ DS+ + ++ IVL EL +G L ++ F++ K R + ++ Q+ +
Sbjct: 105 IIKYLDSF--IEDNELNIVL--ELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAV 160
Query: 289 HFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATL--KRASFAKSVIGTPEFMAPE 346
+HSR ++HRD+K NVFIT TG VK+GDLGL + A S++GTP +M+PE
Sbjct: 161 EHMHSR--RVMHRDIKPANVFITA-TGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPE 217
Query: 347 -MYEEKYDEAVDVYAFGMCMLEMATSEYP-YSECQNAAQIYRKVTSGRKPNSFHKVKIPE 404
++E Y+ D+++ G + EMA + P Y + N + +K+ P + +
Sbjct: 218 RIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEK 277
Query: 405 VKEIIEGCIRTDKNER 420
++E++ CI D ++R
Sbjct: 278 LRELVSMCICPDPHQR 293
>gi|191252782 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 109 bits (272), Expect = 2e-23
Identities = 115/425 (27%), Positives = 188/425 (44%), Gaps = 53/425 (12%)
Query: 48 GKAEPRPRSSRLSRRSSVDLGLLSSWSLPAS---PAPDPPDPPDSAGPGPARSPPPS--- 101
G P+ R S L RR + L ++ + P S P P P P+S+ P + PPS
Sbjct: 245 GSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVA 304
Query: 102 -----SKEPPEGTWTE------GAPVKAAEDS-ARPELPDSAVGPGSREP---------L 140
+ P GT++ +P K+ + A +LP + GS L
Sbjct: 305 KAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNL 364
Query: 141 RVPEAVALERRREQEEKEDMET--------QAVATSPDGRYLKFD-IEIGRGSFKTVYRG 191
+P+ + + E + T + V D R L ++IG GS V
Sbjct: 365 YLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLA 424
Query: 192 LDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIV 251
+ + +VA + RK R R+ EV +++ QH N+V Y KS L G+ V
Sbjct: 425 REKHSGRQVAVKMMDLRKQQR--RELLFNEVVIMRDYQHFNVVEMY---KSYLVGEELWV 479
Query: 252 LVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFIT 311
L+ E + G L + + R + + +L+ L +LH++ ++HRD+K D++ +T
Sbjct: 480 LM-EFLQGGALTDIVSQVR-LNEEQIATVCEAVLQALAYLHAQ--GVIHRDIKSDSILLT 535
Query: 312 GPTGSVKIGDLGLATL--KRASFAKSVIGTPEFMAPEMYEEK-YDEAVDVYAFGMCMLEM 368
G VK+ D G K KS++GTP +MAPE+ Y VD+++ G+ ++EM
Sbjct: 536 -LDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEM 594
Query: 369 ATSEYPYSECQNAAQIYRKVTSGRKPN--SFHKVKIPEVKEIIEGCIRTDKNERFTIQDL 426
E PY + Q +++ P + HKV P +++ +E + D ER T Q+L
Sbjct: 595 VDGEPPYFS-DSPVQAMKRLRDSPPPKLKNSHKVS-PVLRDFLERMLVRDPQERATAQEL 652
Query: 427 LAHAF 431
L H F
Sbjct: 653 LDHPF 657
Score = 39.7 bits (91), Expect = 0.018
Identities = 37/122 (30%), Positives = 48/122 (39%), Gaps = 28/122 (22%)
Query: 971 PGGQESPSPHTAE------------VESEASPPPARPLPG-------EARLAPISEEGKP 1011
PGG+ SPSP T E + + A+ PP+ PG + P ++ P
Sbjct: 241 PGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPP 300
Query: 1012 QLVGRFQVTSSKEPA---EPLPLQPT-SPTLSGSPKPSTPQLTSESSDTEDSAGGGPETR 1067
LV + Q S +P PL T SP S P+T QL S S G P T
Sbjct: 301 SLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRS-----SPAGSPRTW 355
Query: 1068 EA 1069
A
Sbjct: 356 HA 357
>gi|191252780 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 109 bits (272), Expect = 2e-23
Identities = 115/425 (27%), Positives = 188/425 (44%), Gaps = 53/425 (12%)
Query: 48 GKAEPRPRSSRLSRRSSVDLGLLSSWSLPAS---PAPDPPDPPDSAGPGPARSPPPS--- 101
G P+ R S L RR + L ++ + P S P P P P+S+ P + PPS
Sbjct: 245 GSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVA 304
Query: 102 -----SKEPPEGTWTE------GAPVKAAEDS-ARPELPDSAVGPGSREP---------L 140
+ P GT++ +P K+ + A +LP + GS L
Sbjct: 305 KAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNL 364
Query: 141 RVPEAVALERRREQEEKEDMET--------QAVATSPDGRYLKFD-IEIGRGSFKTVYRG 191
+P+ + + E + T + V D R L ++IG GS V
Sbjct: 365 YLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLA 424
Query: 192 LDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIV 251
+ + +VA + RK R R+ EV +++ QH N+V Y KS L G+ V
Sbjct: 425 REKHSGRQVAVKMMDLRKQQR--RELLFNEVVIMRDYQHFNVVEMY---KSYLVGEELWV 479
Query: 252 LVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFIT 311
L+ E + G L + + R + + +L+ L +LH++ ++HRD+K D++ +T
Sbjct: 480 LM-EFLQGGALTDIVSQVR-LNEEQIATVCEAVLQALAYLHAQ--GVIHRDIKSDSILLT 535
Query: 312 GPTGSVKIGDLGLATL--KRASFAKSVIGTPEFMAPEMYEEK-YDEAVDVYAFGMCMLEM 368
G VK+ D G K KS++GTP +MAPE+ Y VD+++ G+ ++EM
Sbjct: 536 -LDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEM 594
Query: 369 ATSEYPYSECQNAAQIYRKVTSGRKPN--SFHKVKIPEVKEIIEGCIRTDKNERFTIQDL 426
E PY + Q +++ P + HKV P +++ +E + D ER T Q+L
Sbjct: 595 VDGEPPYFS-DSPVQAMKRLRDSPPPKLKNSHKVS-PVLRDFLERMLVRDPQERATAQEL 652
Query: 427 LAHAF 431
L H F
Sbjct: 653 LDHPF 657
Score = 39.7 bits (91), Expect = 0.018
Identities = 37/122 (30%), Positives = 48/122 (39%), Gaps = 28/122 (22%)
Query: 971 PGGQESPSPHTAE------------VESEASPPPARPLPG-------EARLAPISEEGKP 1011
PGG+ SPSP T E + + A+ PP+ PG + P ++ P
Sbjct: 241 PGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPP 300
Query: 1012 QLVGRFQVTSSKEPA---EPLPLQPT-SPTLSGSPKPSTPQLTSESSDTEDSAGGGPETR 1067
LV + Q S +P PL T SP S P+T QL S S G P T
Sbjct: 301 SLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRS-----SPAGSPRTW 355
Query: 1068 EA 1069
A
Sbjct: 356 HA 357
>gi|9910476 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 109 bits (272), Expect = 2e-23
Identities = 115/425 (27%), Positives = 188/425 (44%), Gaps = 53/425 (12%)
Query: 48 GKAEPRPRSSRLSRRSSVDLGLLSSWSLPAS---PAPDPPDPPDSAGPGPARSPPPS--- 101
G P+ R S L RR + L ++ + P S P P P P+S+ P + PPS
Sbjct: 245 GSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVA 304
Query: 102 -----SKEPPEGTWTE------GAPVKAAEDS-ARPELPDSAVGPGSREP---------L 140
+ P GT++ +P K+ + A +LP + GS L
Sbjct: 305 KAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNL 364
Query: 141 RVPEAVALERRREQEEKEDMET--------QAVATSPDGRYLKFD-IEIGRGSFKTVYRG 191
+P+ + + E + T + V D R L ++IG GS V
Sbjct: 365 YLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLA 424
Query: 192 LDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIV 251
+ + +VA + RK R R+ EV +++ QH N+V Y KS L G+ V
Sbjct: 425 REKHSGRQVAVKMMDLRKQQR--RELLFNEVVIMRDYQHFNVVEMY---KSYLVGEELWV 479
Query: 252 LVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFIT 311
L+ E + G L + + R + + +L+ L +LH++ ++HRD+K D++ +T
Sbjct: 480 LM-EFLQGGALTDIVSQVR-LNEEQIATVCEAVLQALAYLHAQ--GVIHRDIKSDSILLT 535
Query: 312 GPTGSVKIGDLGLATL--KRASFAKSVIGTPEFMAPEMYEEK-YDEAVDVYAFGMCMLEM 368
G VK+ D G K KS++GTP +MAPE+ Y VD+++ G+ ++EM
Sbjct: 536 -LDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEM 594
Query: 369 ATSEYPYSECQNAAQIYRKVTSGRKPN--SFHKVKIPEVKEIIEGCIRTDKNERFTIQDL 426
E PY + Q +++ P + HKV P +++ +E + D ER T Q+L
Sbjct: 595 VDGEPPYFS-DSPVQAMKRLRDSPPPKLKNSHKVS-PVLRDFLERMLVRDPQERATAQEL 652
Query: 427 LAHAF 431
L H F
Sbjct: 653 LDHPF 657
Score = 39.7 bits (91), Expect = 0.018
Identities = 37/122 (30%), Positives = 48/122 (39%), Gaps = 28/122 (22%)
Query: 971 PGGQESPSPHTAE------------VESEASPPPARPLPG-------EARLAPISEEGKP 1011
PGG+ SPSP T E + + A+ PP+ PG + P ++ P
Sbjct: 241 PGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPP 300
Query: 1012 QLVGRFQVTSSKEPA---EPLPLQPT-SPTLSGSPKPSTPQLTSESSDTEDSAGGGPETR 1067
LV + Q S +P PL T SP S P+T QL S S G P T
Sbjct: 301 SLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRS-----SPAGSPRTW 355
Query: 1068 EA 1069
A
Sbjct: 356 HA 357
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 108 bits (271), Expect = 2e-23
Identities = 99/376 (26%), Positives = 179/376 (47%), Gaps = 25/376 (6%)
Query: 63 SSVDLGLLSSWSLPASP--APDPPDPPDSAGPGPARSPPPS-SKEPPEGTWTEGAPVKAA 119
SS L + + PA P + D D D A P P +P P +K + E PV
Sbjct: 155 SSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPT 214
Query: 120 EDSARPELPDSAVGPGSREPLRVPEAVALERRR----EQEEKEDMETQAVATSPDGRYLK 175
D A P S + P + ++++ ++E E + + P +Y +
Sbjct: 215 RDVATS--PISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTR 272
Query: 176 FDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVR 235
F+ +IG+G+ TVY +D T EVA ++ ++ + +++ E+ +++ ++PNIV
Sbjct: 273 FE-KIGQGASGTVYTAMDVATGQEVAIKQMNLQQ--QPKKELIINEILVMRENKNPNIVN 329
Query: 236 FYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRV 295
+ DS+ ++ ++ +V+ E + G+L + M + R+ L+ L FLHS
Sbjct: 330 YLDSY--LVGDELWVVM--EYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEFLHSN- 383
Query: 296 PPILHRDLKCDNVFITGPTGSVKIGDLGLAT--LKRASFAKSVIGTPEFMAPEMYEEK-Y 352
++HRD+K DN+ + G GSVK+ D G S +++GTP +MAPE+ K Y
Sbjct: 384 -QVIHRDIKSDNILL-GMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY 441
Query: 353 DEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEV-KEIIEG 411
VD+++ G+ +EM E PY +Y T+G P + K+ + ++ +
Sbjct: 442 GPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG-TPELQNPEKLSAIFRDFLNR 500
Query: 412 CIRTDKNERFTIQDLL 427
C+ D +R + ++LL
Sbjct: 501 CLEMDVEKRGSAKELL 516
>gi|121583542 mitogen-activated protein kinase kinase kinase 15
[Homo sapiens]
Length = 788
Score = 108 bits (271), Expect = 2e-23
Identities = 81/265 (30%), Positives = 132/265 (49%), Gaps = 18/265 (6%)
Query: 178 IEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFY 237
+ +G+G++ VY G D V +A E+ R + Q EE+ + K L+H NIV++
Sbjct: 131 VVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYS--QPLHEEIALHKYLKHRNIVQYL 188
Query: 238 DSWKSVLRGQVCIVLVTELMTSGTLKTYLR-RFREMKPRVLQRWSRQILRGLHFLHSRVP 296
S G + I + E + G+L LR ++ MK ++ +++QIL GL +LH
Sbjct: 189 GSVSE--NGYIKIFM--EQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHEN-- 242
Query: 297 PILHRDLKCDNVFITGPTGSVKIGDLGLATLKRAS----FAKSVIGTPEFMAPEMYEE-- 350
I+HRD+K DNV + +G VKI D G T KR + ++ GT ++MAPE+ ++
Sbjct: 243 QIVHRDIKGDNVLVNTYSGVVKISDFG--TSKRLAGVNPCTETFTGTLQYMAPEIIDQGP 300
Query: 351 -KYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEII 409
Y D+++ G ++EMATS+ P+ E KV + + E + I
Sbjct: 301 RGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFI 360
Query: 410 EGCIRTDKNERFTIQDLLAHAFFRE 434
C D ++R T +LL F R+
Sbjct: 361 LSCFEPDPHKRATTAELLREGFLRQ 385
>gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 108 bits (270), Expect = 3e-23
Identities = 104/374 (27%), Positives = 164/374 (43%), Gaps = 37/374 (9%)
Query: 76 PASPAPDPPD-PPDSAGPGPARSPPPSSKEPPEGTWTEGAPV-----------KAAEDSA 123
P +P +P D P+ G P SS T GAP + A +
Sbjct: 64 PGAPKGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPAC 123
Query: 124 RPELPDSAVGPGSREPLRVPEAVALERRREQEEKEDMETQAVATSPDGR-YLKFDIEIGR 182
P P PG R P R P+ V+ E+ R Q V D R YL I+IG
Sbjct: 124 TPAAPAVPGPPGPRSPQREPQRVSHEQFRAA-------LQLVVDPGDPRSYLDNFIKIGE 176
Query: 183 GSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKS 242
GS V + VA ++ RK R R+ EV +++ QH N+V Y+S+
Sbjct: 177 GSTGIVCIATVRSSGKLVAVKKMDLRKQQR--RELLFNEVVIMRDYQHENVVEMYNSY-- 232
Query: 243 VLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRD 302
++ ++ +V+ E + G L + R M + +L+ L LH++ ++HRD
Sbjct: 233 LVGDELWVVM--EFLEGGALTDIVTHTR-MNEEQIAAVCLAVLQALSVLHAQ--GVIHRD 287
Query: 303 LKCDNVFITGPTGSVKIGDLGLATL--KRASFAKSVIGTPEFMAPEMYEE-KYDEAVDVY 359
+K D++ +T G VK+ D G K KS++GTP +MAPE+ Y VD++
Sbjct: 288 IKSDSILLTHD-GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIW 346
Query: 360 AFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKP--NSFHKVKIPEVKEIIEGCIRTDK 417
+ G+ ++EM E PY + + + + P + HKV P +K ++ + D
Sbjct: 347 SLGIMVIEMVDGEPPYFN-EPPLKAMKMIRDNLPPRLKNLHKVS-PSLKGFLDRLLVRDP 404
Query: 418 NERFTIQDLLAHAF 431
+R T +LL H F
Sbjct: 405 AQRATAAELLKHPF 418
Score = 33.1 bits (74), Expect = 1.7
Identities = 32/115 (27%), Positives = 46/115 (40%), Gaps = 12/115 (10%)
Query: 881 WSSLPTTSP----PTFSPTCSQVTLSSPFFPPCPSTSSFPSTTAAPLLSLASAFSLAVMT 936
W SL S P P C +T P P P+ +A L++ + S +
Sbjct: 39 WQSLIEESARRPKPLVDPAC--ITSIQPGAPKGEPHDVAPNGPSAGGLAIPQSSSSSSRP 96
Query: 937 VAQSLLSPSPGLL----SQSPPAPPSPLPSLPLPPPVAPGGQESPSPHTAEVESE 987
++ +PSPG+L S+ APP+ P+ P P P G SP V E
Sbjct: 97 PTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVP--GPPGPRSPQREPQRVSHE 149
Score = 32.0 bits (71), Expect = 3.8
Identities = 26/85 (30%), Positives = 33/85 (38%), Gaps = 17/85 (20%)
Query: 966 PPPVAPGGQESPSPHTAEVESEASPPP--ARPLPGEARLAPISEEGKPQLVGRFQVTSSK 1023
P VAP G + + S +S PP AR P L P + E PQL
Sbjct: 71 PHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASE--PQLA--------- 119
Query: 1024 EPAEPLPLQPTSPTLSGSPKPSTPQ 1048
P P +P + G P P +PQ
Sbjct: 120 ----PPACTPAAPAVPGPPGPRSPQ 140
>gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 108 bits (270), Expect = 3e-23
Identities = 104/374 (27%), Positives = 164/374 (43%), Gaps = 37/374 (9%)
Query: 76 PASPAPDPPD-PPDSAGPGPARSPPPSSKEPPEGTWTEGAPV-----------KAAEDSA 123
P +P +P D P+ G P SS T GAP + A +
Sbjct: 64 PGAPKGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPAC 123
Query: 124 RPELPDSAVGPGSREPLRVPEAVALERRREQEEKEDMETQAVATSPDGR-YLKFDIEIGR 182
P P PG R P R P+ V+ E+ R Q V D R YL I+IG
Sbjct: 124 TPAAPAVPGPPGPRSPQREPQRVSHEQFRAA-------LQLVVDPGDPRSYLDNFIKIGE 176
Query: 183 GSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKS 242
GS V + VA ++ RK R R+ EV +++ QH N+V Y+S+
Sbjct: 177 GSTGIVCIATVRSSGKLVAVKKMDLRKQQR--RELLFNEVVIMRDYQHENVVEMYNSY-- 232
Query: 243 VLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRD 302
++ ++ +V+ E + G L + R M + +L+ L LH++ ++HRD
Sbjct: 233 LVGDELWVVM--EFLEGGALTDIVTHTR-MNEEQIAAVCLAVLQALSVLHAQ--GVIHRD 287
Query: 303 LKCDNVFITGPTGSVKIGDLGLATL--KRASFAKSVIGTPEFMAPEMYEE-KYDEAVDVY 359
+K D++ +T G VK+ D G K KS++GTP +MAPE+ Y VD++
Sbjct: 288 IKSDSILLTHD-GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIW 346
Query: 360 AFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKP--NSFHKVKIPEVKEIIEGCIRTDK 417
+ G+ ++EM E PY + + + + P + HKV P +K ++ + D
Sbjct: 347 SLGIMVIEMVDGEPPYFN-EPPLKAMKMIRDNLPPRLKNLHKVS-PSLKGFLDRLLVRDP 404
Query: 418 NERFTIQDLLAHAF 431
+R T +LL H F
Sbjct: 405 AQRATAAELLKHPF 418
Score = 33.1 bits (74), Expect = 1.7
Identities = 32/115 (27%), Positives = 46/115 (40%), Gaps = 12/115 (10%)
Query: 881 WSSLPTTSP----PTFSPTCSQVTLSSPFFPPCPSTSSFPSTTAAPLLSLASAFSLAVMT 936
W SL S P P C +T P P P+ +A L++ + S +
Sbjct: 39 WQSLIEESARRPKPLVDPAC--ITSIQPGAPKGEPHDVAPNGPSAGGLAIPQSSSSSSRP 96
Query: 937 VAQSLLSPSPGLL----SQSPPAPPSPLPSLPLPPPVAPGGQESPSPHTAEVESE 987
++ +PSPG+L S+ APP+ P+ P P P G SP V E
Sbjct: 97 PTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVP--GPPGPRSPQREPQRVSHE 149
Score = 32.0 bits (71), Expect = 3.8
Identities = 26/85 (30%), Positives = 33/85 (38%), Gaps = 17/85 (20%)
Query: 966 PPPVAPGGQESPSPHTAEVESEASPPP--ARPLPGEARLAPISEEGKPQLVGRFQVTSSK 1023
P VAP G + + S +S PP AR P L P + E PQL
Sbjct: 71 PHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASE--PQLA--------- 119
Query: 1024 EPAEPLPLQPTSPTLSGSPKPSTPQ 1048
P P +P + G P P +PQ
Sbjct: 120 ----PPACTPAAPAVPGPPGPRSPQ 140
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 108 bits (270), Expect = 3e-23
Identities = 97/322 (30%), Positives = 154/322 (47%), Gaps = 25/322 (7%)
Query: 180 IGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDS 239
IG GSF VY+G + VA + S E + E+E+++GL+HPNIV DS
Sbjct: 10 IGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDS 69
Query: 240 WKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPIL 299
+++ +V+VT+ G L L ++ +Q + Q++ L++LHS IL
Sbjct: 70 FETDKE----VVVVTD-YAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSH--RIL 122
Query: 300 HRDLKCDNVFITGPTGSVKIGDLGLATLKRAS--FAKSVIGTPEFMAPEMYEEK-YDEAV 356
HRD+K N+ + G +K+ D G A + S+ GTP +M+PE+ EE+ YD
Sbjct: 123 HRDMKPQNILL-AKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTA 181
Query: 357 DVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRK-PNSFHKVKIPEVKEIIEGCIRT 415
D+++ G + E+A P+ A I++ V+ K P + P K ++G +
Sbjct: 182 DLWSVGCILYELAVGTPPF----YATSIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTK 237
Query: 416 DKNERFTIQDLLAHAFFREERGVHVELAEEDDGE------KPGLKLWLRMEDARRGGRPR 469
D +R + DLL H F + E A D G P L++ L+ E A R P+
Sbjct: 238 DPRQRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPFTSRLPPELQV-LKDEQAHRLA-PK 295
Query: 470 DNQAIEFLFQLGRDAAEEVAQE 491
NQ+ L Q + AEE Q+
Sbjct: 296 GNQS-RILTQAYKRMAEEAMQK 316
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,758,461
Number of Sequences: 37866
Number of extensions: 4417005
Number of successful extensions: 74061
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 637
Number of HSP's successfully gapped in prelim test: 2845
Number of HSP's that attempted gapping in prelim test: 27012
Number of HSP's gapped (non-prelim): 31481
length of query: 1243
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1129
effective length of database: 13,930,794
effective search space: 15727866426
effective search space used: 15727866426
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.