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Search of human proteins with 33356544
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33356544 phosphoinositide-specific phospholipase C beta 1
isoform b [Homo sapiens]
(1173 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso... 2341 0.0
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 2271 0.0
gi|11386139 phospholipase C beta 3 [Homo sapiens] 1288 0.0
gi|95147333 phospholipase C, beta 2 [Homo sapiens] 1061 0.0
gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] 820 0.0
gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] 820 0.0
gi|14249340 phospholipase C, delta 4 [Homo sapiens] 342 9e-94
gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 332 2e-90
gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 332 2e-90
gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 328 2e-89
gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 328 2e-89
gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 326 9e-89
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 326 9e-89
gi|78499633 phospholipase C, eta 2 [Homo sapiens] 318 1e-86
gi|25188201 phospholipase C, zeta 1 [Homo sapiens] 312 1e-84
gi|19115964 phospholipase C delta 3 [Homo sapiens] 307 3e-83
gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] 187 4e-47
gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] 174 4e-43
gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] 174 4e-43
gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] 174 4e-43
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 164 4e-40
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 164 4e-40
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 157 4e-38
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 67 1e-10
gi|148746195 trichohyalin [Homo sapiens] 62 2e-09
gi|28460688 taxilin [Homo sapiens] 62 2e-09
gi|33946313 ninein isoform 4 [Homo sapiens] 62 3e-09
gi|33946321 ninein isoform 5 [Homo sapiens] 62 3e-09
gi|148536871 ninein isoform 1 [Homo sapiens] 62 3e-09
gi|148536869 ninein isoform 2 [Homo sapiens] 62 3e-09
>gi|33356544 phosphoinositide-specific phospholipase C beta 1 isoform
b [Homo sapiens]
Length = 1173
Score = 2341 bits (6066), Expect = 0.0
Identities = 1173/1173 (100%), Positives = 1173/1173 (100%)
Query: 1 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE 60
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
Sbjct: 1 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE 60
Query: 61 TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV 120
TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV
Sbjct: 61 TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV 120
Query: 121 AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA 180
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
Sbjct: 121 AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA 180
Query: 181 DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL 240
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
Sbjct: 181 DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL 240
Query: 241 TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLS 300
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLS
Sbjct: 241 TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLS 300
Query: 301 GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV 360
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
Sbjct: 301 GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV 360
Query: 361 ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ 420
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
Sbjct: 361 ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ 420
Query: 421 QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK 480
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
Sbjct: 421 QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK 480
Query: 481 KLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM 540
KLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
Sbjct: 481 KLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM 540
Query: 541 SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK 600
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
Sbjct: 541 SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK 600
Query: 601 GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK 660
GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
Sbjct: 601 GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK 660
Query: 661 HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG 720
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
Sbjct: 661 HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG 720
Query: 721 NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER 780
NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
Sbjct: 721 NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER 780
Query: 781 NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK 840
NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
Sbjct: 781 NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK 840
Query: 841 EADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS 900
EADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS
Sbjct: 841 EADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS 900
Query: 901 VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL 960
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
Sbjct: 901 VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL 960
Query: 961 RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR 1020
RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
Sbjct: 961 RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR 1020
Query: 1021 QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI 1080
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
Sbjct: 1021 QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI 1080
Query: 1081 TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP 1140
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
Sbjct: 1081 TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP 1140
Query: 1141 KGEGSSSFLSETCHEDPSVSPNFTPPNPQALKW 1173
KGEGSSSFLSETCHEDPSVSPNFTPPNPQALKW
Sbjct: 1141 KGEGSSSFLSETCHEDPSVSPNFTPPNPQALKW 1173
>gi|12083581 phosphoinositide-specific phospholipase C beta 1 isoform
a [Homo sapiens]
Length = 1216
Score = 2271 bits (5886), Expect = 0.0
Identities = 1141/1141 (100%), Positives = 1141/1141 (100%)
Query: 1 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE 60
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
Sbjct: 1 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE 60
Query: 61 TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV 120
TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV
Sbjct: 61 TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV 120
Query: 121 AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA 180
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
Sbjct: 121 AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA 180
Query: 181 DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL 240
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
Sbjct: 181 DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL 240
Query: 241 TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLS 300
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLS
Sbjct: 241 TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLS 300
Query: 301 GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV 360
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
Sbjct: 301 GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV 360
Query: 361 ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ 420
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
Sbjct: 361 ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ 420
Query: 421 QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK 480
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
Sbjct: 421 QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK 480
Query: 481 KLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM 540
KLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
Sbjct: 481 KLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM 540
Query: 541 SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK 600
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
Sbjct: 541 SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK 600
Query: 601 GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK 660
GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
Sbjct: 601 GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK 660
Query: 661 HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG 720
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
Sbjct: 661 HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG 720
Query: 721 NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER 780
NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
Sbjct: 721 NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER 780
Query: 781 NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK 840
NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
Sbjct: 781 NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK 840
Query: 841 EADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS 900
EADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS
Sbjct: 841 EADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS 900
Query: 901 VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL 960
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
Sbjct: 901 VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL 960
Query: 961 RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR 1020
RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
Sbjct: 961 RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR 1020
Query: 1021 QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI 1080
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
Sbjct: 1021 QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI 1080
Query: 1081 TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP 1140
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
Sbjct: 1081 TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP 1140
Query: 1141 K 1141
K
Sbjct: 1141 K 1141
>gi|11386139 phospholipase C beta 3 [Homo sapiens]
Length = 1234
Score = 1288 bits (3332), Expect = 0.0
Identities = 662/1213 (54%), Positives = 859/1213 (70%), Gaps = 81/1213 (6%)
Query: 1 MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE 60
MAGAQPGVHALQL+P V ++L++G+KF+KWD++++ + LR DP GFF YWT N E
Sbjct: 1 MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNME 60
Query: 61 TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNI-GRLEQRMITVVYGPDLVNISHLNL 119
+ LD+S ++D R GR+A+ PKDPK+RE+L G RLE++++TVV GPD VN LN
Sbjct: 61 VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNF 120
Query: 120 VAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFS 179
+A Q++ AK W+ E+F LA N+LAQN SR+ FL KAYTKLKLQV +GRIP+KNI ++FS
Sbjct: 121 MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS 180
Query: 180 ADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPY 239
AD+KRVETALE+C L +R++SI ++F+ E++ FLN LC RP+ID I E GAK KPY
Sbjct: 181 ADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY 240
Query: 240 LTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYL 299
LT++Q+MDFIN KQRDPRLNE+LYPPL+ Q ++LIEKYEPN + Q+S++GF RYL
Sbjct: 241 LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL 300
Query: 300 SGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRC 359
GEENG++ E LDL+ DM+QPLS YFINSSHNTYLTAGQLAG SSVEMYRQ LL GCRC
Sbjct: 301 GGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC 360
Query: 360 VELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPK 419
VELD WKGR EEEP ITHGFTMTTE+ ++V+EAIAE AFKTSP+P++LSFENHVDS K
Sbjct: 361 VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK 420
Query: 420 QQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEG--- 476
QQAKMAEYCR IFGDALL+EPL+KYPL GVPLPSP DLM +ILVKNKK+ S+ G
Sbjct: 421 QQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDS 480
Query: 477 SGKKKLSEQASNTYSDSSSMFEPSSPGAGE------------------------------ 506
+G+K+ EQ+++ S+SS+ EPSSP G
Sbjct: 481 AGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGD 540
Query: 507 ------------ADTESDDDDDDD----DCKKSSMDEGTAGSEAMATEEMSNLVNYIQPV 550
AD E +++D+++ D KK + DEGTA SE ATEEMS LVNYI+PV
Sbjct: 541 EGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV 600
Query: 551 KFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYM 610
KF+SFE ++KRNK FEMSSFVETK +EQLTKSP+EFVEYNK QLSRIYPKGTRVDSSNYM
Sbjct: 601 KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM 660
Query: 611 PQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIV 670
PQLFWN GCQ+VALNFQT+D+AMQ+N G++EYNG+SGY LKPEFMRRPDK FDPFTE IV
Sbjct: 661 PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV 720
Query: 671 DGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEE 730
DGIVAN L VK+ISGQFLSD+KVG YVEVDMFGLPVDTRRK ++T+TSQGN+ NPVW+EE
Sbjct: 721 DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRK-YRTRTSQGNSFNPVWDEE 779
Query: 731 PIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVF 790
P F KVVLPTLA LRIA +EEGGKF+GHRILPV AIR GYHY+CLRNE NQPL LPA+
Sbjct: 780 PFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALL 839
Query: 791 VYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSE 850
+Y E DY+PD + D EAL NPI++V+LM+QRA+QLAAL E E + +E +
Sbjct: 840 IYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQ 899
Query: 851 APSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTI 910
S+ + P + ++ + P P + PA S+ +P + +DLI S+L+EV +
Sbjct: 900 LGSQPSSNPTPSPLDASPRRPPGPT-----TSPASTSLSSPGQRDDLIASILSEVAPTPL 954
Query: 911 EELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQND--YLRRRAALEK 968
+EL+ K+ VKL+ + +++++L K+H +K L + + Q + R AL
Sbjct: 955 DELRGHKALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGG 1014
Query: 969 SAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEK 1028
+A + K+ E + ++ + +++Q Q LL LR+ Q +E
Sbjct: 1015 AADVEDTKEGE--------------------DEAKRYQEFQNRQVQSLLELREAQVDAEA 1054
Query: 1029 YQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDK 1088
++ EH++ +Q+L +V + Q K+LKE+ E+EKKEL+K +D+KR I+EAK +DK
Sbjct: 1055 QRRLEHLRQALQRLREVVLDANTTQFKRLKEMNEREKKELQKILDRKRHNSISEAKMRDK 1114
Query: 1089 SQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKGEGSSSF 1148
+ E E TE+ R +I E V I+RLEEAQ +R ++LV +++ QQ+ +E+PK +
Sbjct: 1115 HKKEAELTEINRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPK---LLAQ 1171
Query: 1149 LSETCHEDPSVSP 1161
L++ C E + P
Sbjct: 1172 LAQECQEQRARLP 1184
>gi|95147333 phospholipase C, beta 2 [Homo sapiens]
Length = 1185
Score = 1061 bits (2743), Expect = 0.0
Identities = 553/1142 (48%), Positives = 761/1142 (66%), Gaps = 56/1142 (4%)
Query: 13 LKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDA 72
L P V L +G +F+KWDD++T+ +P+ILR DP+G++ YWT Q+KE E LD++ ++D
Sbjct: 8 LLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDT 67
Query: 73 RCGRHAKAPKDPKLRELLDVG-NIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWT 131
R G+ AK PK KLR++ ++ + +TVV GPD+V+++ N V+++E V K W
Sbjct: 68 RFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWA 127
Query: 132 NEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEA 191
+V +L + L N SR FL+K KLK+Q+ EG+IP+KN +++F ADRKRVE AL A
Sbjct: 128 EDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSA 187
Query: 192 CSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINL 251
C LP +ND+I EDF VY+ FL +LCPRPEID IF+ + AK+KPY+T + + FIN
Sbjct: 188 CHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQ 247
Query: 252 KQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEK 311
KQRD RLN +L+PP + +QVQ LI+KYEP+ A++GQ+S +G + +L G EN V++ +K
Sbjct: 248 KQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDK 307
Query: 312 LDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAE 371
L L+ DM+QPL+HYFINSSHNTYLTAGQ +G SS EMYRQVLLSGCRCVELDCWKG+ +
Sbjct: 308 LLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPD 367
Query: 372 EEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLI 431
EEP+ITHGFTMTT+I FKE IEAIAE AFKTSP+PI+LSFENHVDSP+QQAKMAEYCR I
Sbjct: 368 EEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTI 427
Query: 432 FGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYS 491
FGD LL EPLEK+PL+ GVPLPSP DL KIL+KNKK ++ SG S+
Sbjct: 428 FGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKK-----NQFSGPTSSSKDTGGEAE 482
Query: 492 DSSSMFEPSSPG---AGEADTESDDDD------------DDDDCKKSSMDEGTAGSEAMA 536
SS P+ G AGE TE ++++ D+++ KK DEGTAG E A
Sbjct: 483 GSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTA 542
Query: 537 TEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSR 596
EEMS+LVNYIQP KF SFE S ++N+S+ +SSF E K + L+K+ V+FV+YNK Q+SR
Sbjct: 543 YEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSR 602
Query: 597 IYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMR 656
IYPKGTR+DSSNYMPQ+FWNAGCQMVALNFQTMDL MQ NM ++E+NG+SGY LK EFMR
Sbjct: 603 IYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMR 662
Query: 657 RPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTK 716
RPDK F+PF+ +D +VA TLS+ +ISGQFLS++ V TYVEV++FGLP D +R+ ++TK
Sbjct: 663 RPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRR-YRTK 721
Query: 717 TSQG-NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYIC 775
S N++NPVW+EEP VF+K+++P LA LR+AV EEG KF+GHRI+P+ A+ GYH++C
Sbjct: 722 LSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLC 781
Query: 776 LRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDE 835
L +E N PLT+PA+F+++E+KDY+P +AD+ AL+NPI++ + + ++ +L
Sbjct: 782 LHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKL-------- 833
Query: 836 EEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTE 895
KEA G P + NG L P + GS A A
Sbjct: 834 ----KEAMGGLPEKPFPLASPVASQVNG-----ALAP----------TSNGSPAARAGAR 874
Query: 896 DLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEI 955
+ E ++EEL++ K VKLQ++H KE+++L +R ++ +L++ + E+
Sbjct: 875 EEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAEL 934
Query: 956 QNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQ 1015
+ A + K S+KK + + + +D ++ +LKD+ + +
Sbjct: 935 GPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDG----RVRELKDRLELE 990
Query: 1016 LLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKK 1075
LL +EQY +K +H+ I K+ ++A E Q +LK LKE E + KE+KKK++ K
Sbjct: 991 LLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETK 1050
Query: 1076 RQEKI--TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQ 1133
R E+I + DK E K E+ S+IQEVVQ IK++ E + QEKL EK +
Sbjct: 1051 RLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLE 1110
Query: 1134 QI 1135
QI
Sbjct: 1111 QI 1112
>gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]
Length = 1194
Score = 820 bits (2119), Expect = 0.0
Identities = 474/1184 (40%), Positives = 692/1184 (58%), Gaps = 84/1184 (7%)
Query: 18 VSDSLKKGTKFVKWDDDSTIVTP-IILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGR 76
V L++GT F +++++S + P + + D GFF W + KE ++L+ SL+ R G
Sbjct: 13 VPSFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGA 72
Query: 77 HAKAPKDPKLRELLDVGNIGR----LEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTN 132
PKDPK+ L+ +G+ LE R++ V G DLVNIS +VA EV K+W
Sbjct: 73 ---IPKDPKILAALEA--VGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVE 127
Query: 133 EVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADR--KRVETALE 190
+ S+ N A N+S L+K + KL G+IP+++I R F++ + K + AL+
Sbjct: 128 GLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALK 187
Query: 191 ACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFIN 250
LPS +ND I F+ E + +CPR +I+++F + YLTVDQ++ F+N
Sbjct: 188 ELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLN 247
Query: 251 LKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPE 310
QRDPRLNEIL+P ++ +IE YEP+ L +KG IS DGF RYL +EN V +
Sbjct: 248 EHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLD 307
Query: 311 KLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTA 370
+L+L ++M PL+HYFI+SSHNTYLT Q G SSVEMYRQVLL+GCRCVELDCW G+
Sbjct: 308 RLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGE 367
Query: 371 EEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRL 430
++EP+ITHG M T+I FK+VI+AI E AF TS +P++LSFENH S QQ KM++YC
Sbjct: 368 DQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHC-SKYQQYKMSKYCED 426
Query: 431 IFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKK--------------KSHKSSEG 476
+FGD LL + LE +PLE G LPSP DL KIL+KNK+ ++ E
Sbjct: 427 LFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGES 486
Query: 477 SGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTA------ 530
+ + E + +S+ E + P + S DD + +S+ +G
Sbjct: 487 ASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTVEDEQ 546
Query: 531 ---------GSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTK 581
G+ +S ++NY QPVKF+ F ++++RN + MSSF E+ GL L
Sbjct: 547 AWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKT 606
Query: 582 SPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYE 641
+EFV YNK Q+SRIYPKG RVDSSNYMPQ+FWNAGCQMV+LN+QT DLAMQ+N G +E
Sbjct: 607 HAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFE 666
Query: 642 YNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDM 701
YNG GY LKP+FMRRPD+ FDPF+E VDG++A T SV++ISGQFLSDKK+GTYVEVDM
Sbjct: 667 YNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDM 726
Query: 702 FGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRI 761
+GLP DT RK F+T+ N +NPV+ EE VF+KV+LP LA LRIAVY++ K IG RI
Sbjct: 727 YGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRI 786
Query: 762 LPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLME 821
LP+ ++ GY +I LRNE N+PL+LP +F I +K YVPD + D+++ALS+P +++++ E
Sbjct: 787 LPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITE 846
Query: 822 QRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHS 881
+RA Q+ A+ +E +D + PS+ + A +TP+ S+ +
Sbjct: 847 KRADQMRAMGIE-------TSDIADVPSDTSKNDKKGKANTA---KANVTPQSSSELRPT 896
Query: 882 QPAPGSVKAPAKTE-DLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKK 940
A + AK +LI V IE+LKQ K+++K KK KE+ L K+H K+
Sbjct: 897 TTAALASGVEAKKGIELIPQV-------RIEDLKQMKAYLKHLKKQQKELNSLKKKHAKE 949
Query: 941 TTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIE--------- 991
+ + K H T+ ++I Y + ++ EK +K KKK GS+ +E
Sbjct: 950 HSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKG-------GSNCLEMKKETEIKI 1002
Query: 992 QDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQN 1051
Q L + ++++ K+ +++N + + L++KL A E Q
Sbjct: 1003 QTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQT 1062
Query: 1052 NQLKKLKEICEKEKKELKKKMDKKRQEKITEAKS-KDKSQMEEEKTEMIRSYIQEVVQYI 1110
QLK + KE + + K+ + + I++ KS K+K++ E E+ S ++ ++
Sbjct: 1063 QQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEER 1122
Query: 1111 KRLEEAQSKRQEKLVEKHKEIRQQILDEKPKGEGSSSFLSETCH 1154
KRL QSK ++L K+++ + L+ K + L ++CH
Sbjct: 1123 KRLAMKQSKEMDQL----KKVQLEHLEFLEK---QNEQLLKSCH 1159
>gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]
Length = 1175
Score = 820 bits (2117), Expect = 0.0
Identities = 468/1154 (40%), Positives = 678/1154 (58%), Gaps = 77/1154 (6%)
Query: 18 VSDSLKKGTKFVKWDDDSTIVTP-IILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGR 76
V L++GT F +++++S + P + + D GFF W + KE ++L+ SL+ R G
Sbjct: 13 VPSFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGA 72
Query: 77 HAKAPKDPKLRELLDVGNIGR----LEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTN 132
PKDPK+ L+ +G+ LE R++ V G DLVNIS +VA EV K+W
Sbjct: 73 ---IPKDPKILAALEA--VGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVE 127
Query: 133 EVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADR--KRVETALE 190
+ S+ N A N+S L+K + KL G+IP+++I R F++ + K + AL+
Sbjct: 128 GLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALK 187
Query: 191 ACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFIN 250
LPS +ND I F+ E + +CPR +I+++F + YLTVDQ++ F+N
Sbjct: 188 ELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLN 247
Query: 251 LKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPE 310
QRDPRLNEIL+P ++ +IE YEP+ L +KG IS DGF RYL +EN V +
Sbjct: 248 EHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLD 307
Query: 311 KLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTA 370
+L+L ++M PL+HYFI+SSHNTYLT Q G SSVEMYRQVLL+GCRCVELDCW G+
Sbjct: 308 RLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGE 367
Query: 371 EEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRL 430
++EP+ITHG M T+I FK+VI+AI E AF TS +P++LSFENH S QQ KM++YC
Sbjct: 368 DQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHC-SKYQQYKMSKYCED 426
Query: 431 IFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKK--------------KSHKSSEG 476
+FGD LL + LE +PLE G LPSP DL KIL+KNK+ ++ E
Sbjct: 427 LFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGES 486
Query: 477 SGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTA------ 530
+ + E + +S+ E + P + S DD + +S+ +G
Sbjct: 487 ASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTVEDEQ 546
Query: 531 ---------GSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTK 581
G+ +S ++NY QPVKF+ F ++++RN + MSSF E+ GL L
Sbjct: 547 AWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKT 606
Query: 582 SPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYE 641
+EFV YNK Q+SRIYPKG RVDSSNYMPQ+FWNAGCQMV+LN+QT DLAMQ+N G +E
Sbjct: 607 HAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFE 666
Query: 642 YNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDM 701
YNG GY LKP+FMRRPD+ FDPF+E VDG++A T SV++ISGQFLSDKK+GTYVEVDM
Sbjct: 667 YNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDM 726
Query: 702 FGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRI 761
+GLP DT RK F+T+ N +NPV+ EE VF+KV+LP LA LRIAVY++ K IG RI
Sbjct: 727 YGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRI 786
Query: 762 LPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLME 821
LP+ ++ GY +I LRNE N+PL+LP +F I +K YVPD + D+++ALS+P +++++ E
Sbjct: 787 LPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITE 846
Query: 822 QRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHS 881
+RA Q+ A+ +E +D + PS+ + A +TP+ S+ +
Sbjct: 847 KRADQMRAMGIE-------TSDIADVPSDTSKNDKKGKANTA---KANVTPQSSSELRPT 896
Query: 882 QPAPGSVKAPAKTE-DLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKK 940
A + AK +LI V IE+LKQ K+++K KK KE+ L K+H K+
Sbjct: 897 TTAALASGVEAKKGIELIPQV-------RIEDLKQMKAYLKHLKKQQKELNSLKKKHAKE 949
Query: 941 TTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIE--------- 991
+ + K H T+ ++I Y + ++ EK +K KKK GS+ +E
Sbjct: 950 HSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKG-------GSNCLEMKKETEIKI 1002
Query: 992 QDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQN 1051
Q L + ++++ K+ +++N + + L++KL A E Q
Sbjct: 1003 QTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQT 1062
Query: 1052 NQLKKLKEICEKEKKELKKKMDKKRQEKITEAKS-KDKSQMEEEKTEMIRSYIQEVVQYI 1110
QLK + KE + + K+ + + I++ KS K+K++ E E+ S ++ ++
Sbjct: 1063 QQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEER 1122
Query: 1111 KRLEEAQSKRQEKL 1124
KRL QSK ++L
Sbjct: 1123 KRLAMKQSKEMDQL 1136
>gi|14249340 phospholipase C, delta 4 [Homo sapiens]
Length = 762
Score = 342 bits (878), Expect = 9e-94
Identities = 245/718 (34%), Positives = 373/718 (51%), Gaps = 67/718 (9%)
Query: 98 LEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYT 157
LEQ V +G S+L+L+A E A+ W + L L +M L++ +
Sbjct: 87 LEQGFTIVFHG----RRSNLDLMANSVEEAQIWMRGLQLLVD--LVTSMDHQERLDQWLS 140
Query: 158 KL--KLQVTPEGRIPLKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPE 210
+ +G++ + + RL D++ + +A +S++ ++ E+F
Sbjct: 141 DWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAAD--TSQSGTLEGEEFVQ- 197
Query: 211 VYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQ 270
F L R E+ +F F A + LT+ + +DF+ +Q++ E
Sbjct: 198 ----FYKALTKRAEVQELFESFSADGQK-LTLLEFLDFLQEEQKERDCTS--------EL 244
Query: 271 VQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSS 330
LI++YEP++S + +S+DGF+ YL ++ + +P L + +DM+QPL+HYFI SS
Sbjct: 245 ALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSS 304
Query: 331 HNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKE 390
HNTYL QL G SSVE Y + L GCRCVE+D W G + E PV+ HG T+T+ I FK+
Sbjct: 305 HNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGE--PVVYHGHTLTSRILFKD 362
Query: 391 VIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGV 450
V+ +A+ AF+TS +P++LS E H S +QQ MA + I G+ LL L+
Sbjct: 363 VVATVAQYAFQTSDYPVILSLETHC-SWEQQQTMARHLTEILGEQLLSTTLDGV---LPT 418
Query: 451 PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTE 510
LPSP +L KILVK KK + + +++ + + S FE E + +
Sbjct: 419 QLPSPEELRRKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFET------EPEPQ 472
Query: 511 SDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSF 570
+ + D KKS + + +S+LV Y++ V F SF SK+ +E+SSF
Sbjct: 473 EQNLQNKDKKKKS---------KPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSF 523
Query: 571 VETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMD 630
ETK + ++ EFV++N QLSR+YP G R DSSNY PQ WNAGCQMVA+N QT
Sbjct: 524 SETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAG 583
Query: 631 LAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLS- 689
L M I G + NG GY LKP+F+R F P E + A TL +++ISGQ L
Sbjct: 584 LEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHP--EKPISPFKAQTLLIQVISGQQLPK 641
Query: 690 -DKK-----VGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLA 743
DK V V+V +FG+ +DT R+ +T + N NP W + + +V++P LA
Sbjct: 642 VDKTKEGSIVDPLVKVQIFGVRLDTARQ--ETNYVENNGFNPYWGQ--TLCFRVLVPELA 697
Query: 744 CLRIAVYEEGGK----FIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKD 797
LR V + K FIG LP ++ GY +I L ++ L ++FVYI +++
Sbjct: 698 MLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYICIQE 755
>gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]
Length = 1095
Score = 332 bits (850), Expect = 2e-90
Identities = 238/775 (30%), Positives = 384/775 (49%), Gaps = 86/775 (11%)
Query: 43 LRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRM 102
L TD Q + + ++ E LD+S +K+ R G++ + ++ L + + E
Sbjct: 137 LDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQI-------CEDCA 189
Query: 103 ITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAY 156
++++G N L+LVA +VA W + + L + + + N + F+
Sbjct: 190 FSILHGE---NYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKT 246
Query: 157 TKLKLQVTPEGRIPLKN----IYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVY 212
V G I L++ + + + K + L+ + S+ + T E +
Sbjct: 247 VFEAADVDGNG-IMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTR--VTEEEF 303
Query: 213 RVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQ 272
LC RPE+ + + +K+K YL + +M F+ +Q + E + +
Sbjct: 304 CEAFCELCTRPEVYFLLVQI-SKNKEYLDANDLMLFLEAEQGVTHITEDICLDI------ 356
Query: 273 VLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHN 332
I +YE + +KG +++DGF +YL E + PE+ + +DM+QPLSHY+IN+SHN
Sbjct: 357 --IRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHN 414
Query: 333 TYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVI 392
TYL Q G + + Y + L GCR VELD G ++ EP++ + MTT +SF+ VI
Sbjct: 415 TYLIEDQFRGPADINGYIRALKMGCRSVELDVSDG--SDNEPILCNRNNMTTHVSFRSVI 472
Query: 393 EAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPL 452
E I + AF S +P++L NH P+Q+ MA+ + +FG+ L E PL S L
Sbjct: 473 EVINKFAFVASEYPLILCLGNHCSLPQQKV-MAQQMKKVFGNKLYTEA----PLPSESYL 527
Query: 453 PSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESD 512
PSP L I+VK KK PS P E + +D
Sbjct: 528 PSPEKLKRMIIVKGKKL-----------------------------PSDPDVLEGEV-TD 557
Query: 513 DDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVE 572
+D++ + ++ S+D + E+S+LV+ + V++ FE+S K +EM SF E
Sbjct: 558 EDEEAEMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSE 617
Query: 573 TKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLA 632
T+ + P +FV YNK LSRIYP R+DSSN PQ FWN GCQ+VA+NFQT
Sbjct: 618 TEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPM 677
Query: 633 MQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKK 692
M ++ G + NG GY L+P MR +F T+GI+ G+ L +KIISGQ K
Sbjct: 678 MDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPK 737
Query: 693 --------VGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFK-KVVLPTLA 743
+ YV +++ G+P D + +TKT Q N+ NP+++E F+ +V LP LA
Sbjct: 738 GACAKGDVIDPYVCIEIHGIPADCSEQ--RTKTVQQNSDNPIFDE---TFEFQVNLPELA 792
Query: 744 CLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEV 795
+R V ++ G +FIG +P + ++PGY ++ LR+ + +FV+I +
Sbjct: 793 MIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAI 847
>gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
Length = 997
Score = 332 bits (850), Expect = 2e-90
Identities = 238/775 (30%), Positives = 384/775 (49%), Gaps = 86/775 (11%)
Query: 43 LRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRM 102
L TD Q + + ++ E LD+S +K+ R G++ + ++ L + + E
Sbjct: 39 LDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQI-------CEDCA 91
Query: 103 ITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAY 156
++++G N L+LVA +VA W + + L + + + N + F+
Sbjct: 92 FSILHGE---NYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKT 148
Query: 157 TKLKLQVTPEGRIPLKN----IYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVY 212
V G I L++ + + + K + L+ + S+ + T E +
Sbjct: 149 VFEAADVDGNG-IMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTR--VTEEEF 205
Query: 213 RVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQ 272
LC RPE+ + + +K+K YL + +M F+ +Q + E + +
Sbjct: 206 CEAFCELCTRPEVYFLLVQI-SKNKEYLDANDLMLFLEAEQGVTHITEDICLDI------ 258
Query: 273 VLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHN 332
I +YE + +KG +++DGF +YL E + PE+ + +DM+QPLSHY+IN+SHN
Sbjct: 259 --IRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHN 316
Query: 333 TYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVI 392
TYL Q G + + Y + L GCR VELD G ++ EP++ + MTT +SF+ VI
Sbjct: 317 TYLIEDQFRGPADINGYIRALKMGCRSVELDVSDG--SDNEPILCNRNNMTTHVSFRSVI 374
Query: 393 EAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPL 452
E I + AF S +P++L NH P+Q+ MA+ + +FG+ L E PL S L
Sbjct: 375 EVINKFAFVASEYPLILCLGNHCSLPQQKV-MAQQMKKVFGNKLYTEA----PLPSESYL 429
Query: 453 PSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESD 512
PSP L I+VK KK PS P E + +D
Sbjct: 430 PSPEKLKRMIIVKGKKL-----------------------------PSDPDVLEGEV-TD 459
Query: 513 DDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVE 572
+D++ + ++ S+D + E+S+LV+ + V++ FE+S K +EM SF E
Sbjct: 460 EDEEAEMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSE 519
Query: 573 TKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLA 632
T+ + P +FV YNK LSRIYP R+DSSN PQ FWN GCQ+VA+NFQT
Sbjct: 520 TEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPM 579
Query: 633 MQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKK 692
M ++ G + NG GY L+P MR +F T+GI+ G+ L +KIISGQ K
Sbjct: 580 MDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPK 639
Query: 693 --------VGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFK-KVVLPTLA 743
+ YV +++ G+P D + +TKT Q N+ NP+++E F+ +V LP LA
Sbjct: 640 GACAKGDVIDPYVCIEIHGIPADCSEQ--RTKTVQQNSDNPIFDE---TFEFQVNLPELA 694
Query: 744 CLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEV 795
+R V ++ G +FIG +P + ++PGY ++ LR+ + +FV+I +
Sbjct: 695 MIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAI 749
>gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]
Length = 756
Score = 328 bits (840), Expect = 2e-89
Identities = 223/617 (36%), Positives = 316/617 (51%), Gaps = 67/617 (10%)
Query: 197 SRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDP 256
S+ DS+ E+ F L R EID F+E A S L+VDQ++ F+ +QR+
Sbjct: 191 SQTDSLEDEEI-----EAFYKMLTQRVEIDRTFAE-AAGSGETLSVDQLVTFLQHQQRE- 243
Query: 257 RLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNE 316
E P L LIE+YEP+ + + Q++ DGF+ YL + S + +
Sbjct: 244 ---EAAGPALALS----LIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQ 296
Query: 317 DMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVI 376
DM QPLSHY ++SSHNTYL QLAG SS E Y + L GCRC+ELDCW G +EP+I
Sbjct: 297 DMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDG--PNQEPII 354
Query: 377 THGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDAL 436
HG+T T++I F +V+ AI + AFK SP+P++LS ENH + +QQ MA + I G L
Sbjct: 355 YHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHC-TLEQQRVMARHLHAILGPML 413
Query: 437 LMEPLEKYPLESGV--PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSS 494
L PL+ GV LPSP L KIL+K KK
Sbjct: 414 LNRPLD------GVTNSLPSPEQLKGKILLKGKK------------------------LG 443
Query: 495 SMFEPSSPGAGEADTESDDDDD---DDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVK 551
+ P G EA SD+D+ +D+ +S + + +E+S++V Y + V
Sbjct: 444 GLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVH 503
Query: 552 FESFEISKKRNKSF-EMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYM 610
F F ++F EM+SF E + L L +S FV +N LSRIYP G R DSSNY
Sbjct: 504 FGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYS 563
Query: 611 PQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIV 670
P WN GCQ+VALNFQT M + G ++ NG GY LKP F+R P+ F+P
Sbjct: 564 PVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQG 623
Query: 671 DGIVANTLSVKIISGQFL------SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVN 724
L++++ISGQ L + V V V++ G+ D + +T N N
Sbjct: 624 PWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASR--QTAVITNNGFN 681
Query: 725 PVWEEEPIVFKKVVLPTLACLRIAV--YEEGGK--FIGHRILPVQAIRPGYHYICLRNER 780
P W+ E F +VV+P LA +R V Y+ K FIG +P+ +++ GY ++ L ++
Sbjct: 682 PWWDTE-FAF-EVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKN 739
Query: 781 NQPLTLPAVFVYIEVKD 797
+FV I ++D
Sbjct: 740 GDQHPSATLFVKISLQD 756
>gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
Length = 777
Score = 328 bits (840), Expect = 2e-89
Identities = 223/617 (36%), Positives = 316/617 (51%), Gaps = 67/617 (10%)
Query: 197 SRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDP 256
S+ DS+ E+ F L R EID F+E A S L+VDQ++ F+ +QR+
Sbjct: 212 SQTDSLEDEEI-----EAFYKMLTQRVEIDRTFAE-AAGSGETLSVDQLVTFLQHQQRE- 264
Query: 257 RLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNE 316
E P L LIE+YEP+ + + Q++ DGF+ YL + S + +
Sbjct: 265 ---EAAGPALALS----LIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQ 317
Query: 317 DMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVI 376
DM QPLSHY ++SSHNTYL QLAG SS E Y + L GCRC+ELDCW G +EP+I
Sbjct: 318 DMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDG--PNQEPII 375
Query: 377 THGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDAL 436
HG+T T++I F +V+ AI + AFK SP+P++LS ENH + +QQ MA + I G L
Sbjct: 376 YHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHC-TLEQQRVMARHLHAILGPML 434
Query: 437 LMEPLEKYPLESGV--PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSS 494
L PL+ GV LPSP L KIL+K KK
Sbjct: 435 LNRPLD------GVTNSLPSPEQLKGKILLKGKK------------------------LG 464
Query: 495 SMFEPSSPGAGEADTESDDDDD---DDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVK 551
+ P G EA SD+D+ +D+ +S + + +E+S++V Y + V
Sbjct: 465 GLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVH 524
Query: 552 FESFEISKKRNKSF-EMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYM 610
F F ++F EM+SF E + L L +S FV +N LSRIYP G R DSSNY
Sbjct: 525 FGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYS 584
Query: 611 PQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIV 670
P WN GCQ+VALNFQT M + G ++ NG GY LKP F+R P+ F+P
Sbjct: 585 PVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQG 644
Query: 671 DGIVANTLSVKIISGQFL------SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVN 724
L++++ISGQ L + V V V++ G+ D + +T N N
Sbjct: 645 PWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASR--QTAVITNNGFN 702
Query: 725 PVWEEEPIVFKKVVLPTLACLRIAV--YEEGGK--FIGHRILPVQAIRPGYHYICLRNER 780
P W+ E F +VV+P LA +R V Y+ K FIG +P+ +++ GY ++ L ++
Sbjct: 703 PWWDTE-FAF-EVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKN 760
Query: 781 NQPLTLPAVFVYIEVKD 797
+FV I ++D
Sbjct: 761 GDQHPSATLFVKISLQD 777
>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
Length = 1127
Score = 326 bits (835), Expect = 9e-89
Identities = 247/802 (30%), Positives = 392/802 (48%), Gaps = 88/802 (10%)
Query: 20 DSLKKGTKFVKWDDDSTIVTP-IILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHA 78
+S+ +G++ K +S I +L D Q + + ++ E +D+ +K+ R G++
Sbjct: 141 NSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNT 200
Query: 79 KAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLA 138
+ + + + E +V+YG N L+LVA +VA W + L
Sbjct: 201 DIFRSNGISDQIS-------EDCAFSVIYGE---NYESLDLVANSADVANIWVTGLRYLI 250
Query: 139 T------NLL--AQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIY---RLFSADRKRVET 187
+ ++L +Q+ R +++ + ++++ V G I L N R + K +
Sbjct: 251 SYGKHTLDMLESSQDNMRTSWVSQMFSEI--DVDNLGHITLCNAVQCIRNLNPGLKTSKI 308
Query: 188 ALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMD 247
L+ L S++ + + T E + + LC RPEI + +F + +K +L +M
Sbjct: 309 ELKFKELHKSKDKA--GTEVTKEEFIEVFHELCTRPEIYFLLVQFSS-NKEFLDTKDLMM 365
Query: 248 FINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVV 307
F+ +Q +NE E +I KYEP+ KG +S+DGF YL + +
Sbjct: 366 FLEAEQGVAHINE--------EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIF 417
Query: 308 SPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKG 367
PE + +DM QPLSHYFINSSHNTYL Q G S + Y + L GCR VELD W G
Sbjct: 418 DPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDG 477
Query: 368 RTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEY 427
+ EPVI G TMT++I F+ VI+ I + AF S +P++L ENH S KQQ M ++
Sbjct: 478 --PDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHC-SIKQQKVMVQH 534
Query: 428 CRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQAS 487
+ + GD L P LPSP L KIL+K KK S S SG +
Sbjct: 535 MKKLLGDKLYTTS----PNVEESYLPSPDVLKGKILIKAKKLS---SNCSGVE------- 580
Query: 488 NTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDE--GTAGSEAMATEEMSNLVN 545
G+ E + + K +M++ +E+S LV+
Sbjct: 581 -----------------GDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVS 623
Query: 546 YIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVD 605
+ V+F+ F++S + K +E+ SF E + ++P +FV YNK L+R++P R+D
Sbjct: 624 ICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRID 683
Query: 606 SSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPF 665
SSN PQ FW GCQ+VA+NFQT L M +N+G + NG GY L+P MR F
Sbjct: 684 SSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSAN 743
Query: 666 TEGIVDGIVANTLSVKIISGQFLSDKK--------VGTYVEVDMFGLPVDTRRKAFKTKT 717
T+ V G+ L +KIISGQ K V YV V++ G+P D + +TKT
Sbjct: 744 TKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ--RTKT 801
Query: 718 SQGNAVNPVWEEEPIVFK-KVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHY 773
N P+++E F+ ++ LP LA +R V ++ G +FIG +P + ++ GY +
Sbjct: 802 VHQNGDAPIFDES---FEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 858
Query: 774 ICLRNERNQPLTLPAVFVYIEV 795
+ L++ + L ++FV++ +
Sbjct: 859 VPLQSLTGEVLAHASLFVHVAI 880
>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
Length = 1001
Score = 326 bits (835), Expect = 9e-89
Identities = 247/802 (30%), Positives = 392/802 (48%), Gaps = 88/802 (10%)
Query: 20 DSLKKGTKFVKWDDDSTIVTP-IILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHA 78
+S+ +G++ K +S I +L D Q + + ++ E +D+ +K+ R G++
Sbjct: 15 NSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNT 74
Query: 79 KAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLA 138
+ + + + E +V+YG N L+LVA +VA W + L
Sbjct: 75 DIFRSNGISDQIS-------EDCAFSVIYGE---NYESLDLVANSADVANIWVTGLRYLI 124
Query: 139 T------NLL--AQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIY---RLFSADRKRVET 187
+ ++L +Q+ R +++ + ++++ V G I L N R + K +
Sbjct: 125 SYGKHTLDMLESSQDNMRTSWVSQMFSEI--DVDNLGHITLCNAVQCIRNLNPGLKTSKI 182
Query: 188 ALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMD 247
L+ L S++ + + T E + + LC RPEI + +F + +K +L +M
Sbjct: 183 ELKFKELHKSKDKA--GTEVTKEEFIEVFHELCTRPEIYFLLVQFSS-NKEFLDTKDLMM 239
Query: 248 FINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVV 307
F+ +Q +NE E +I KYEP+ KG +S+DGF YL + +
Sbjct: 240 FLEAEQGVAHINE--------EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIF 291
Query: 308 SPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKG 367
PE + +DM QPLSHYFINSSHNTYL Q G S + Y + L GCR VELD W G
Sbjct: 292 DPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDG 351
Query: 368 RTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEY 427
+ EPVI G TMT++I F+ VI+ I + AF S +P++L ENH S KQQ M ++
Sbjct: 352 --PDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHC-SIKQQKVMVQH 408
Query: 428 CRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQAS 487
+ + GD L P LPSP L KIL+K KK S S SG +
Sbjct: 409 MKKLLGDKLYTTS----PNVEESYLPSPDVLKGKILIKAKKLS---SNCSGVE------- 454
Query: 488 NTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDE--GTAGSEAMATEEMSNLVN 545
G+ E + + K +M++ +E+S LV+
Sbjct: 455 -----------------GDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVS 497
Query: 546 YIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVD 605
+ V+F+ F++S + K +E+ SF E + ++P +FV YNK L+R++P R+D
Sbjct: 498 ICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRID 557
Query: 606 SSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPF 665
SSN PQ FW GCQ+VA+NFQT L M +N+G + NG GY L+P MR F
Sbjct: 558 SSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSAN 617
Query: 666 TEGIVDGIVANTLSVKIISGQFLSDKK--------VGTYVEVDMFGLPVDTRRKAFKTKT 717
T+ V G+ L +KIISGQ K V YV V++ G+P D + +TKT
Sbjct: 618 TKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ--RTKT 675
Query: 718 SQGNAVNPVWEEEPIVFK-KVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHY 773
N P+++E F+ ++ LP LA +R V ++ G +FIG +P + ++ GY +
Sbjct: 676 VHQNGDAPIFDES---FEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 732
Query: 774 ICLRNERNQPLTLPAVFVYIEV 795
+ L++ + L ++FV++ +
Sbjct: 733 VPLQSLTGEVLAHASLFVHVAI 754
>gi|78499633 phospholipase C, eta 2 [Homo sapiens]
Length = 1416
Score = 318 bits (816), Expect = 1e-86
Identities = 240/787 (30%), Positives = 372/787 (47%), Gaps = 142/787 (18%)
Query: 117 LNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAYTKLKLQVTPEGRIP 170
L+LV+ EVA+ W + L +L + +RD +L++ + + +G +
Sbjct: 133 LDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEA--DKNGDGSLS 190
Query: 171 LKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEI 225
+ + +L + R+RV+ + ++ E+F F + R ++
Sbjct: 191 IGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQG-TLGFEEFC-----AFYKMMSTRRDL 244
Query: 226 DNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLA 285
+ + + K +L + F+ ++Q+ + E Q +IE++EP
Sbjct: 245 YLLMLTY-SNHKDHLDAASLQRFLQVEQK--------MAGVTLESCQDIIEQFEPCPENK 295
Query: 286 RKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSS 345
KG + +DGF Y + +PE +++DM+QPLSHYFI SSHNTYL QL S
Sbjct: 296 SKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSR 355
Query: 346 VEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPF 405
V+MY VL +GCRCVE+DCW G + EP++ HG+T+T++I FK+VIE I + AF + +
Sbjct: 356 VDMYAWVLQAGCRCVEVDCWDG--PDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEY 413
Query: 406 PILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVK 465
P++LS ENH S QQ KMA+Y I GD L L E LPSP L KILVK
Sbjct: 414 PVILSIENHC-SVIQQKKMAQYLTDILGDKL---DLSSVSSEDATTLPSPQMLKGKILVK 469
Query: 466 NKK-----------------------------------KSHKSSEGSGKKKLSE------ 484
KK + K E + K+KL
Sbjct: 470 GKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESK 529
Query: 485 --QASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDC---------------------- 520
+ + S S PS ++ E D + +D
Sbjct: 530 IRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSK 589
Query: 521 --KKSSMDEGTAGSEAMATEE---------------MSNLVNYIQPVKFESFEISKKRNK 563
K +S++EG G ++ + +S+LV Y + V + +I +
Sbjct: 590 LKKAASVEEGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVA--THDIEMEAAS 647
Query: 564 SFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVA 623
S+++SSF ETK + L + P +++ +N+ QLSRIYP RVDSSNY PQ FWNAGCQMVA
Sbjct: 648 SWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVA 707
Query: 624 LNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKII 683
LN+Q+ +Q+N + NG GY LKP M + F+P +E + G + L ++II
Sbjct: 708 LNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQ--GVFNPNSEDPLPGQLKKQLVLRII 765
Query: 684 SGQFLSDKK----------VGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIV 733
SGQ L + + +VEV++ GLPVD R+ +T+ N NP W EE +V
Sbjct: 766 SGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSRE--QTRVVDDNGFNPTW-EETLV 822
Query: 734 FKKVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVF 790
F V +P +A +R V++ G FIG R L ++ PGY ++ L + + ++F
Sbjct: 823 F-MVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYL-----EGMEEASIF 876
Query: 791 VYIEVKD 797
V++ V D
Sbjct: 877 VHVAVSD 883
>gi|25188201 phospholipase C, zeta 1 [Homo sapiens]
Length = 608
Score = 312 bits (800), Expect = 1e-84
Identities = 212/609 (34%), Positives = 328/609 (53%), Gaps = 65/609 (10%)
Query: 199 NDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRL 258
ND + Q T E +R + R EI IF+ + ++++ L + F+ +Q +
Sbjct: 47 NDRLKQGRITIEEFRAIYRIITHREEIIEIFNTY-SENRKILLASNLAQFLTQEQYAAEM 105
Query: 259 NEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDM 318
++ + +I+KYEP + + Q+S++GF RY+ E + E + +DM
Sbjct: 106 SKAI--------AFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDM 157
Query: 319 SQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITH 378
+ PL+ YFI+SSHNTYL + QL G S + Y L+ GCRC+E+DCW G A+ EPV+ H
Sbjct: 158 THPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDG--AQNEPVVYH 215
Query: 379 GFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLM 438
G+T+T+++ FK VI+AI + AF TS +P++LS ENH S QQ MA+ + FG++LL
Sbjct: 216 GYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHC-STAQQEVMADNLQATFGESLLS 274
Query: 439 EPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFE 498
+ L+ +P LPSP L +KILVKNKK G+ K+ + S
Sbjct: 275 DMLDDFP----DTLPSPEALKFKILVKNKK------IGTLKETHERKGS----------- 313
Query: 499 PSSPGAGEADTESDDDDDDDDCKK---SSMDEGTAGSEAMATEEMSNLVNYIQPVKFESF 555
D D+ D + KK + + + +S+LV Y + KF+SF
Sbjct: 314 ---------DKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSF 364
Query: 556 EISKKRNKSFEMSSFVETKGLEQLTKSPV-EFVEYNKMQLSRIYPKGTRVDSSNYMPQLF 614
+ S+ + E +S ET+ +L+K V EF+ + + ++RIYPK TR DSSN+ PQ F
Sbjct: 365 QHSRLYQQFNENNSIGETQA-RKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEF 423
Query: 615 WNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIV 674
WN GCQMVALNFQT L M + G + NG SGY LKP F+R +F+P I +G+
Sbjct: 424 WNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNP--SNIKEGMP 481
Query: 675 ANTLSVKIISGQFL-----SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEE 729
TL++++ISG L S K + V +++FG+P D ++ +T+ + NA +P W E
Sbjct: 482 I-TLTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQ--QTRVIKKNAFSPRWNE 538
Query: 730 EPIVFKKVV-LPTLACLRIAVYEE----GGKFIGHRILPVQAIRPGYHYICLRNERNQPL 784
F ++ +P LA +R V + G +F+G LP+ + GY I L + + L
Sbjct: 539 ---TFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESL 595
Query: 785 TLPAVFVYI 793
++FVY+
Sbjct: 596 EPASLFVYV 604
>gi|19115964 phospholipase C delta 3 [Homo sapiens]
Length = 789
Score = 307 bits (787), Expect = 3e-83
Identities = 210/698 (30%), Positives = 348/698 (49%), Gaps = 76/698 (10%)
Query: 116 HLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSR------DAFLEKAYTKLKLQVTPEGRI 169
+L+L A E A+ W + L L A + ++L +A + +++ +
Sbjct: 149 NLDLAAPTAEEAQRWVRGLTKLRARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFK--- 205
Query: 170 PLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIF 229
+K++ R+ + D + L S ND + + FL L RPE++ IF
Sbjct: 206 EIKSLLRMVNVDMNDMYAYLLFKECDHSNNDRLEGAEIEE-----FLRRLLKRPELEEIF 260
Query: 230 SEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQ 289
++ + + L+ ++++F+ + + + Q LI+ YE N + +
Sbjct: 261 HQYSGEDR-VLSAPELLEFLEDQGEEGAT---------LARAQQLIQTYELNETAKQHEL 310
Query: 290 ISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMY 349
+++DGFM YL E + + +DM+QPL+HYFI+SSHNTYLT Q+ G SS E Y
Sbjct: 311 MTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAY 370
Query: 350 RQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILL 409
+ GCRCVELDCW+G E PVI HG T+T++I F++V++A+ + AF SP+P++L
Sbjct: 371 VRAFAQGCRCVELDCWEGPGGE--PVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVIL 428
Query: 410 SFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKK 469
S ENH +QQA MA + I GD L+ + L+ E LPSP L ++LVK KK
Sbjct: 429 SLENHCGL-EQQAAMARHLCTILGDMLVTQALDSPNPEE---LPSPEQLKGRVLVKGKKL 484
Query: 470 SHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGT 529
SE + LS++ + E +DD+++++ +++
Sbjct: 485 PAARSEDG--RALSDR----------------------EEEEEDDEEEEEEVEAAAQRRL 520
Query: 530 AGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEY 589
A + E+S L Y + + + + ++SS E K + + ++ FV +
Sbjct: 521 A---KQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRH 577
Query: 590 NKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYR 649
N QL+R+YP G R++S+NY PQ WN+GCQ+VALNFQT M +N G + NG+ GY
Sbjct: 578 NARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYV 637
Query: 650 LKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKK-------VGTYVEVDMF 702
LKP +R+PD FDP G TLS+++++ Q L V V +++
Sbjct: 638 LKPACLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIH 693
Query: 703 GLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYE----EGGKFIG 758
G+P D R+ +T N NP W + + ++ P LA +R V + F+G
Sbjct: 694 GVPADCARQ--ETDYVLNNGFNPRWGQ--TLQFQLRAPELALVRFVVEDYDATSPNDFVG 749
Query: 759 HRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVK 796
LP+ +++ GY +I L ++ L+ +F+ I ++
Sbjct: 750 QFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRIQ 787
>gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]
Length = 2302
Score = 187 bits (476), Expect = 4e-47
Identities = 122/337 (36%), Positives = 190/337 (56%), Gaps = 21/337 (6%)
Query: 269 EQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLN-EDMSQPLSHYFI 327
+++ +I+K+EP+ S+ +G +S +GF R+L +EN ++ N +++ PLS+Y+I
Sbjct: 1344 DEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDESQENIKELQLPLSYYYI 1403
Query: 328 NSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEIS 387
SSHNTYLT QL G SSVE+Y QVLL GCR VELDCW G + P+I HG T+TT+I
Sbjct: 1404 ESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDG--DDGMPIIYHGHTLTTKIP 1461
Query: 388 FKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLE 447
FKEV+EAI AF S PI++S ENH P QQ KMAE + +FG+ L+ + L +
Sbjct: 1462 FKEVVEAIDRSAFINSDLPIIISIENHCSLP-QQRKMAEIFKTVFGEKLVTKFLFETDFS 1520
Query: 448 SGVPLPSPMDLMYKILVKNKK-KSHKSSEGSGKKKLSEQAS---NTYSDSSSMFEPSSPG 503
LPSP L K+L+KNKK K+H++ K+K + AS Y+ ++ P++
Sbjct: 1521 DDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLASMQVQAYNGGNANPRPAN-- 1578
Query: 504 AGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNK 563
+ E +D++D+ D S+ S+ E+ + ++FE E KR K
Sbjct: 1579 ----NEEEEDEEDEYDYDYESL------SDDNILEDRPENKSCNDKLQFEYNEEIPKRIK 1628
Query: 564 SFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK 600
+ S+ + K + + +++ NK + +I P+
Sbjct: 1629 KADNSACNKGK-VYDMELGEEFYLDQNKKESRQIAPE 1664
Score = 128 bits (322), Expect = 3e-29
Identities = 81/236 (34%), Positives = 126/236 (53%), Gaps = 12/236 (5%)
Query: 563 KSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMV 622
K + +SS E + + ++ QL R YP TR+DSSN P +FW G Q+V
Sbjct: 1753 KCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLV 1812
Query: 623 ALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPD----KHFDPFTEGIVDGIVANTL 678
ALN+QT DL + +N M+E NG GY LKP + + + F P E +D +
Sbjct: 1813 ALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPL-ERDLDSMDPAVY 1871
Query: 679 SVKIISGQFL--SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKK 736
S+ I+SGQ + S+ +EVD+ G+P+D+ F+TK N +NP+W E+ +
Sbjct: 1872 SLTIVSGQNVCPSNSMGSPCIEVDVLGMPLDSCH--FRTKPIHRNTLNPMWNEQFLF--H 1927
Query: 737 VVLPTLACLRIAVYEEGGKFI-GHRILPVQAIRPGYHYICLRNERNQPLTLPAVFV 791
V L LR AV E + RI+P++A++ GY ++ LRN N+ L + ++F+
Sbjct: 1928 VHFEDLVFLRFAVVENNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFI 1983
>gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]
Length = 1002
Score = 174 bits (441), Expect = 4e-43
Identities = 119/411 (28%), Positives = 212/411 (51%), Gaps = 35/411 (8%)
Query: 113 NISHLNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAYTKLKLQVTPE 166
++ L+L+ E A+ W + L +L + + D ++++ + + +
Sbjct: 102 HMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEA--DKNGD 159
Query: 167 GRIPLKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCP 221
G + ++ I++L + R++V + + Q T E + VF +
Sbjct: 160 GLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDEN------QGTLTFEEFCVFYKMMSL 213
Query: 222 RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN 281
R ++ + + K K +LTV+++ F+ ++Q+ +N + + +I+K+E +
Sbjct: 214 RRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQK---MNNVT-----TDYCLDIIKKFEVS 264
Query: 282 NSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA 341
K + ++GF ++ + +P ++ +DM QPL +Y+I SSHNTYLT QL
Sbjct: 265 EENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLL 324
Query: 342 GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK 401
S V+MY +VL GCRCVE+DCW G + EPV+ HG+T+T++I F++V+E I + AF
Sbjct: 325 SQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKILFRDVVETINKHAFV 382
Query: 402 TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK 461
+ FP++LS ENH S +QQ K+A+Y + IFGD L + ++ + LPSP L K
Sbjct: 383 KNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQ---LPSPQSLKGK 438
Query: 462 ILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFE-PSSPGAGEADTES 511
ILVK KK + + + + ++S++ S + F+ S G E ES
Sbjct: 439 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVES 489
Score = 145 bits (366), Expect = 2e-34
Identities = 99/309 (32%), Positives = 161/309 (52%), Gaps = 34/309 (11%)
Query: 509 TESDDDDDDDDCKKSSMDEG-------TAGSEAMATEEMSNLVNYIQPVKFESFEISKKR 561
++S DD++D ++S+ EG E+S+LV Y V +
Sbjct: 563 SKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDD--- 619
Query: 562 NKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQM 621
+ + SF ET+ + + + +F+ YN+ QL+RIYP R+DSSN+ P +WNAGCQ+
Sbjct: 620 GTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQL 679
Query: 622 VALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVK 681
VALN+Q+ MQ+N ++ NG GY LKP+ M + F+PF+ + L +K
Sbjct: 680 VALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--FNPFSGDPLPANPKKQLILK 737
Query: 682 IISGQFL----------SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEP 731
+ISGQ L + + +VEV++ GLPVD + +T+ N NPVW EE
Sbjct: 738 VISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD--QTRVVDDNGFNPVW-EET 794
Query: 732 IVFKKVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPA 788
+ F V +P +A +R V++ G F+G R + ++ PGY ++ L + LT +
Sbjct: 795 LTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYL-----EGLTEAS 848
Query: 789 VFVYIEVKD 797
+FV+I + +
Sbjct: 849 IFVHITINE 857
>gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]
Length = 1693
Score = 174 bits (441), Expect = 4e-43
Identities = 119/411 (28%), Positives = 212/411 (51%), Gaps = 35/411 (8%)
Query: 113 NISHLNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAYTKLKLQVTPE 166
++ L+L+ E A+ W + L +L + + D ++++ + + +
Sbjct: 102 HMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEA--DKNGD 159
Query: 167 GRIPLKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCP 221
G + ++ I++L + R++V + + Q T E + VF +
Sbjct: 160 GLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDEN------QGTLTFEEFCVFYKMMSL 213
Query: 222 RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN 281
R ++ + + K K +LTV+++ F+ ++Q+ +N + + +I+K+E +
Sbjct: 214 RRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQK---MNNVT-----TDYCLDIIKKFEVS 264
Query: 282 NSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA 341
K + ++GF ++ + +P ++ +DM QPL +Y+I SSHNTYLT QL
Sbjct: 265 EENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLL 324
Query: 342 GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK 401
S V+MY +VL GCRCVE+DCW G + EPV+ HG+T+T++I F++V+E I + AF
Sbjct: 325 SQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKILFRDVVETINKHAFV 382
Query: 402 TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK 461
+ FP++LS ENH S +QQ K+A+Y + IFGD L + ++ + LPSP L K
Sbjct: 383 KNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQ---LPSPQSLKGK 438
Query: 462 ILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFE-PSSPGAGEADTES 511
ILVK KK + + + + ++S++ S + F+ S G E ES
Sbjct: 439 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVES 489
Score = 145 bits (366), Expect = 2e-34
Identities = 99/309 (32%), Positives = 161/309 (52%), Gaps = 34/309 (11%)
Query: 509 TESDDDDDDDDCKKSSMDEG-------TAGSEAMATEEMSNLVNYIQPVKFESFEISKKR 561
++S DD++D ++S+ EG E+S+LV Y V +
Sbjct: 563 SKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDD--- 619
Query: 562 NKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQM 621
+ + SF ET+ + + + +F+ YN+ QL+RIYP R+DSSN+ P +WNAGCQ+
Sbjct: 620 GTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQL 679
Query: 622 VALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVK 681
VALN+Q+ MQ+N ++ NG GY LKP+ M + F+PF+ + L +K
Sbjct: 680 VALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--FNPFSGDPLPANPKKQLILK 737
Query: 682 IISGQFL----------SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEP 731
+ISGQ L + + +VEV++ GLPVD + +T+ N NPVW EE
Sbjct: 738 VISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD--QTRVVDDNGFNPVW-EET 794
Query: 732 IVFKKVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPA 788
+ F V +P +A +R V++ G F+G R + ++ PGY ++ L + LT +
Sbjct: 795 LTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYL-----EGLTEAS 848
Query: 789 VFVYIEVKD 797
+FV+I + +
Sbjct: 849 IFVHITINE 857
>gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]
Length = 1655
Score = 174 bits (441), Expect = 4e-43
Identities = 119/411 (28%), Positives = 212/411 (51%), Gaps = 35/411 (8%)
Query: 113 NISHLNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAYTKLKLQVTPE 166
++ L+L+ E A+ W + L +L + + D ++++ + + +
Sbjct: 84 HMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEA--DKNGD 141
Query: 167 GRIPLKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCP 221
G + ++ I++L + R++V + + Q T E + VF +
Sbjct: 142 GLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDEN------QGTLTFEEFCVFYKMMSL 195
Query: 222 RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN 281
R ++ + + K K +LTV+++ F+ ++Q+ +N + + +I+K+E +
Sbjct: 196 RRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQK---MNNVT-----TDYCLDIIKKFEVS 246
Query: 282 NSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA 341
K + ++GF ++ + +P ++ +DM QPL +Y+I SSHNTYLT QL
Sbjct: 247 EENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLL 306
Query: 342 GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK 401
S V+MY +VL GCRCVE+DCW G + EPV+ HG+T+T++I F++V+E I + AF
Sbjct: 307 SQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKILFRDVVETINKHAFV 364
Query: 402 TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK 461
+ FP++LS ENH S +QQ K+A+Y + IFGD L + ++ + LPSP L K
Sbjct: 365 KNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQ---LPSPQSLKGK 420
Query: 462 ILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFE-PSSPGAGEADTES 511
ILVK KK + + + + ++S++ S + F+ S G E ES
Sbjct: 421 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVES 471
Score = 145 bits (366), Expect = 2e-34
Identities = 99/309 (32%), Positives = 161/309 (52%), Gaps = 34/309 (11%)
Query: 509 TESDDDDDDDDCKKSSMDEG-------TAGSEAMATEEMSNLVNYIQPVKFESFEISKKR 561
++S DD++D ++S+ EG E+S+LV Y V +
Sbjct: 545 SKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDD--- 601
Query: 562 NKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQM 621
+ + SF ET+ + + + +F+ YN+ QL+RIYP R+DSSN+ P +WNAGCQ+
Sbjct: 602 GTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQL 661
Query: 622 VALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVK 681
VALN+Q+ MQ+N ++ NG GY LKP+ M + F+PF+ + L +K
Sbjct: 662 VALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--FNPFSGDPLPANPKKQLILK 719
Query: 682 IISGQFL----------SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEP 731
+ISGQ L + + +VEV++ GLPVD + +T+ N NPVW EE
Sbjct: 720 VISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD--QTRVVDDNGFNPVW-EET 776
Query: 732 IVFKKVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPA 788
+ F V +P +A +R V++ G F+G R + ++ PGY ++ L + LT +
Sbjct: 777 LTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYL-----EGLTEAS 830
Query: 789 VFVYIEVKD 797
+FV+I + +
Sbjct: 831 IFVHITINE 839
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 164 bits (416), Expect = 4e-40
Identities = 97/265 (36%), Positives = 152/265 (57%), Gaps = 13/265 (4%)
Query: 539 EMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSP-VEFVEYNKMQLSRI 597
E+S LV Y +PV F+ +I +R +MSSF ETK + + K+ +F++YN++QLSRI
Sbjct: 952 ELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRI 1011
Query: 598 YPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRR 657
YPKG R+DSSNY P W G Q+VALNFQT D MQ+N ++ GY L+P MR
Sbjct: 1012 YPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMR- 1070
Query: 658 PDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVG---TYVEVDMFGLPVDTRRKAFK 714
D+ FDPF + + G+ +S++++ + L G +VE+++ G D+ ++ K
Sbjct: 1071 -DEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQ--K 1127
Query: 715 TKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEE----GGKFIGHRILPVQAIRPG 770
T+ N +NPVW +P F ++ P A LR VYEE F+ PV+ ++ G
Sbjct: 1128 TEFVVDNGLNPVWPAKPFHF-QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTG 1186
Query: 771 YHYICLRNERNQPLTLPAVFVYIEV 795
Y + L+N ++ L L ++ + I++
Sbjct: 1187 YRAVPLKNNYSEDLELASLLIKIDI 1211
Score = 150 bits (380), Expect = 5e-36
Identities = 88/205 (42%), Positives = 125/205 (60%), Gaps = 12/205 (5%)
Query: 292 VDGFMRYLSGEENGVVSPEKLDLNED-MSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYR 350
+D F+ +L +EN V + + + D M+ PLSHY+I+SSHNTYLT Q + SS+E Y
Sbjct: 295 LDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYA 354
Query: 351 QVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLS 410
+ L GCRC+ELDCW G + PVI HG T+TT+I F +V+ I E AF S +P++LS
Sbjct: 355 RCLRMGCRCIELDCWDG--PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILS 412
Query: 411 FENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKS 470
E+H S QQ MA+Y + + GD LL +P+E S LPSP L KIL+K+K
Sbjct: 413 IEDHC-SIAQQRNMAQYFKKVLGDTLLTKPVE----ISADGLPSPNQLKRKILIKHK--- 464
Query: 471 HKSSEGSGKKKLSEQASNTYSDSSS 495
K +EGS +++ + +D S+
Sbjct: 465 -KLAEGSAYEEVPTSMMYSENDISN 488
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 164 bits (416), Expect = 4e-40
Identities = 97/265 (36%), Positives = 152/265 (57%), Gaps = 13/265 (4%)
Query: 539 EMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSP-VEFVEYNKMQLSRI 597
E+S LV Y +PV F+ +I +R +MSSF ETK + + K+ +F++YN++QLSRI
Sbjct: 952 ELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRI 1011
Query: 598 YPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRR 657
YPKG R+DSSNY P W G Q+VALNFQT D MQ+N ++ GY L+P MR
Sbjct: 1012 YPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMR- 1070
Query: 658 PDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVG---TYVEVDMFGLPVDTRRKAFK 714
D+ FDPF + + G+ +S++++ + L G +VE+++ G D+ ++ K
Sbjct: 1071 -DEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQ--K 1127
Query: 715 TKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEE----GGKFIGHRILPVQAIRPG 770
T+ N +NPVW +P F ++ P A LR VYEE F+ PV+ ++ G
Sbjct: 1128 TEFVVDNGLNPVWPAKPFHF-QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTG 1186
Query: 771 YHYICLRNERNQPLTLPAVFVYIEV 795
Y + L+N ++ L L ++ + I++
Sbjct: 1187 YRAVPLKNNYSEDLELASLLIKIDI 1211
Score = 150 bits (380), Expect = 5e-36
Identities = 88/205 (42%), Positives = 125/205 (60%), Gaps = 12/205 (5%)
Query: 292 VDGFMRYLSGEENGVVSPEKLDLNED-MSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYR 350
+D F+ +L +EN V + + + D M+ PLSHY+I+SSHNTYLT Q + SS+E Y
Sbjct: 295 LDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYA 354
Query: 351 QVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLS 410
+ L GCRC+ELDCW G + PVI HG T+TT+I F +V+ I E AF S +P++LS
Sbjct: 355 RCLRMGCRCIELDCWDG--PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILS 412
Query: 411 FENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKS 470
E+H S QQ MA+Y + + GD LL +P+E S LPSP L KIL+K+K
Sbjct: 413 IEDHC-SIAQQRNMAQYFKKVLGDTLLTKPVE----ISADGLPSPNQLKRKILIKHK--- 464
Query: 471 HKSSEGSGKKKLSEQASNTYSDSSS 495
K +EGS +++ + +D S+
Sbjct: 465 -KLAEGSAYEEVPTSMMYSENDISN 488
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 157 bits (398), Expect = 4e-38
Identities = 89/179 (49%), Positives = 115/179 (64%), Gaps = 10/179 (5%)
Query: 292 VDGFMRYLSGEENGVVSPEKLDL--NEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMY 349
VD F+ YL EN + EK D +DM+ PLSHY+I+SSHNTYLT QL SS E Y
Sbjct: 287 VDEFLTYLFSRENSIWD-EKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAY 345
Query: 350 RQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILL 409
+ L GCRC+ELDCW G + +PVI HG+T TT+I F +V++AI + AF TS FP++L
Sbjct: 346 IRCLRMGCRCIELDCWDG--PDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVIL 403
Query: 410 SFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKK 468
S E H S +QQ MA+ + +FGD LL +P E S LPSP L KI++K+KK
Sbjct: 404 SIEEHC-SVEQQRHMAKAFKEVFGDLLLTKPTE----ASADQLPSPSQLREKIIIKHKK 457
Score = 156 bits (394), Expect = 1e-37
Identities = 99/270 (36%), Positives = 153/270 (56%), Gaps = 23/270 (8%)
Query: 539 EMSNLVNYIQPVKFESFEISKKRNKSF-EMSSFVETKGLEQLTKSPVEFVEYNKMQLSRI 597
E+S+LV Y +P + N F E+ SFVETK + + PV+ ++YN+ L+R+
Sbjct: 929 ELSDLVVYCKPTSKTKDNLE---NPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRV 985
Query: 598 YPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRR 657
YPKG RVDSSNY P W G QMVALNFQT D MQ+N ++ NG++GY L+PE MR
Sbjct: 986 YPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMR- 1044
Query: 658 PDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVG-----TYVEVDMFGLPVDTRRKA 712
+ +DP I+ TL+VK++ + L K+G +VEV++ G D +
Sbjct: 1045 -TEKYDPMPPESQRKILM-TLTVKVLGARHL--PKLGRSIACPFVEVEICGAEYDNNK-- 1098
Query: 713 FKTKTSQGNAVNPVW--EEEPIVFKKVVLPTLACLRIAVYEE----GGKFIGHRILPVQA 766
FKT N ++P+W +E + F ++ P LA LR VYEE F+ H P++A
Sbjct: 1099 FKTTVVNDNGLSPIWAPTQEKVTF-EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKA 1157
Query: 767 IRPGYHYICLRNERNQPLTLPAVFVYIEVK 796
++ G+ + L+N ++ + L ++ V+ E++
Sbjct: 1158 VKSGFRSVPLKNGYSEDIELASLLVFCEMR 1187
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo sapiens]
Length = 955
Score = 66.6 bits (161), Expect = 1e-10
Identities = 70/330 (21%), Positives = 148/330 (44%), Gaps = 27/330 (8%)
Query: 818 NLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQ 877
++ E++A L + + +E+ +K+ E + E T E V +
Sbjct: 547 HIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTE--VQRLQAQQADAALE 604
Query: 878 ALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFV----KLQKKHYKEMKDL 933
Q S K A+ ++ ++ V ++ KQ K F+ +++++ +++ +L
Sbjct: 605 EFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVEL 664
Query: 934 VKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAK-KDSKKKSEPSSPDHGSSTIEQ 992
H ++ T L+++H + + + D+ R LEK + + + +++ + +
Sbjct: 665 KLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIA 724
Query: 993 DLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNN 1052
D+ A ++ ++LI++ +++QQL+ L + ++ REH
Sbjct: 725 DMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREH----------------EI 768
Query: 1053 QLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMI---RSYIQEVVQY 1109
+ KLK EK K ELKK + + + +A SK K Q+E+E T+ + I E+
Sbjct: 769 VVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLK-QIEKEYTQKLAKSSQIIAELQTT 827
Query: 1110 IKRLEEAQSKRQEKLVEKHKEIRQQILDEK 1139
I L+E S++Q + +++RQ+ DEK
Sbjct: 828 ISSLKEENSQQQLAAERRLQDVRQKFEDEK 857
Score = 53.5 bits (127), Expect = 1e-06
Identities = 34/155 (21%), Positives = 81/155 (52%), Gaps = 12/155 (7%)
Query: 998 DAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQ------N 1051
DA++ QK+++ K+ + ++L L Y S++++ E I+ L +K+ + +CQ
Sbjct: 280 DADV-QKILERKNNEIEELKTL----YRSKQHETEETIRKLEKKVQTLIRDCQVIRETKE 334
Query: 1052 NQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIK 1111
+Q+ +LK+ICE+ + L +KK + E + ++K ++++ TE I+ +++ +
Sbjct: 335 DQIAELKKICEQSTESLNNDWEKKLHNAVAEME-QEKFDLQKQHTENIQELLEDTNVRLN 393
Query: 1112 RLEEAQSKRQEKLVEKHKEIRQQILDEKPKGEGSS 1146
++E + + KE+ ++ + E S+
Sbjct: 394 KMESEYMAQTQSTNHMIKELEARVQQLTGEAENSN 428
Score = 52.4 bits (124), Expect = 3e-06
Identities = 80/391 (20%), Positives = 163/391 (41%), Gaps = 61/391 (15%)
Query: 815 RYVNLMEQRAKQLAALTLEDEEEVKK---EADPGETP---SEAPSEARTTPAENGVNHTT 868
+Y + R+ L+ ED + + E ++P ++ EAR G+ +
Sbjct: 160 QYTGKLRVRSHSLSPTHREDGQNITPKICEVYSKKSPVSLDDSDIEARLNSWNLGIENPR 219
Query: 869 TLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQT---IEELKQQKSFVKLQKK 925
L KP +L + P K+ + +D S + E E + E K + +KLQ+K
Sbjct: 220 YLRQKPIPVSLMT-PKFSLRKSSSFHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQK 278
Query: 926 HYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQN---------DYLRRRAALEKSAKKD--- 973
H +++ +++R + + +L + +K +E + L R + + K+D
Sbjct: 279 HDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIA 338
Query: 974 SKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQL----------LNLRQEQ 1023
KK S + ++ E+ L AEM Q+ DL+ + + + LN + +
Sbjct: 339 ELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESE 398
Query: 1024 YYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEA 1083
Y ++ IK L ++ + E +N+ L++ K I +EK EL++ E + E
Sbjct: 399 YMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLI--QEKAELERCYQITCSE-LQEV 455
Query: 1084 KSKDKSQMEEEKTEMIRSYIQ-------------------------EVVQYIKRLEEAQS 1118
K++ ++ + +EK ++ Y Q + I+ LE+
Sbjct: 456 KAR-RNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVC 514
Query: 1119 KRQEKLVEKHKEIRQQILDEKPKGEGSSSFL 1149
+ +++L E + +QQ+ D++ K + S L
Sbjct: 515 QLKQQLQESELQRKQQLRDQENKFQMEKSHL 545
Score = 45.8 bits (107), Expect = 2e-04
Identities = 57/280 (20%), Positives = 123/280 (43%), Gaps = 52/280 (18%)
Query: 889 KAPAKTEDLIQS--VLTEVEAQTIEELKQ-------------QKSFVKLQKKHYKEMKDL 933
K K + LI+ V+ E + I ELK+ +K + +E DL
Sbjct: 314 KLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDL 373
Query: 934 VKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQD 993
K+H + +L+++ + N+++++Y+ + + K+ + + + S+ Q
Sbjct: 374 QKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQK 433
Query: 994 LAALDAEMTQ-------KLIDLKDKQQ-------------QQLLNLRQEQYYSEKYQKRE 1033
L AE+ + +L ++K ++ +Q + L Q +Y ++ ++
Sbjct: 434 LIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQ 493
Query: 1034 HIKLLIQKLTDVAEECQNN--QLKKLKEICEKEKK------ELKKKMDKKRQEKITEAKS 1085
L K + + EE + N QLK+ + E ++K E K +M+K + I E K+
Sbjct: 494 EHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKA 553
Query: 1086 KD-KSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKL 1124
D +S++++ K ++ + I + EEA +++E+L
Sbjct: 554 HDLQSELDKGK--------EDTQKKIHKFEEALKEKEEQL 585
Score = 41.2 bits (95), Expect = 0.006
Identities = 48/231 (20%), Positives = 111/231 (48%), Gaps = 17/231 (7%)
Query: 901 VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL 960
V+ ++EAQ + +L+++ V Q+K L++ K+ +EH N+++ +
Sbjct: 722 VIADMEAQ-VHKLREELINVNSQRKQQLVELGLLREEEKQRAT--REHEIVVNKLKAESE 778
Query: 961 RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLK--------DKQ 1012
+ + L+K+ +++ E ++ IE++ A+ +Q + +L+ +
Sbjct: 779 KMKIELKKTHAAETEMTLEKANSK--LKQIEKEYTQKLAKSSQIIAELQTTISSLKEENS 836
Query: 1013 QQQLLNLRQEQYYSEKYQ--KREHIKLLIQKLTDVAEECQN--NQLKKLKEICEKEKKEL 1068
QQQL R+ Q +K++ K++ I+ Q + + +E +N NQ++ ++ + ++ E
Sbjct: 837 QQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELES 896
Query: 1069 KKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSK 1119
++++ RQE T+ K + + +E + I S +V KR Q +
Sbjct: 897 QEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEE 947
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 62.4 bits (150), Expect = 2e-09
Identities = 51/243 (20%), Positives = 122/243 (50%), Gaps = 31/243 (12%)
Query: 911 EELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSA 970
+E ++++ ++KL+++ +E ++ ++ ++ + +E K E + + L++R E+
Sbjct: 480 QEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQE-EEERLQQRLRSEQQL 538
Query: 971 KKDSKKKSEPSSPDHGSSTIEQD-----LAALDAEMTQKLIDLKDKQQQQLLNLRQEQYY 1025
+++ +++ E +EQ+ L E +L+ +++++QQ L QE+
Sbjct: 539 RREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERL 598
Query: 1026 SEKYQKREHIKLLIQK-------LTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQE 1078
++ KRE ++ L Q+ + EE + QL K +E E+ +++L+++ ++R++
Sbjct: 599 EQRL-KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657
Query: 1079 KITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDE 1138
++ K + EEE+ E Q +KR E + + QE E+ ++ R++I
Sbjct: 658 RL-------KREEEEERLE----------QRLKREHEEERREQELAEEEQEQARERIKSR 700
Query: 1139 KPK 1141
PK
Sbjct: 701 IPK 703
Score = 57.0 bits (136), Expect = 1e-07
Identities = 50/260 (19%), Positives = 134/260 (51%), Gaps = 19/260 (7%)
Query: 899 QSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDL-VKRHHKKTTDLIK-EHTTKYNEIQ 956
Q + E + + ++L++++ + ++KH +E ++ +KR ++ D +K E T+ +E +
Sbjct: 411 QQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE 470
Query: 957 NDYLRRRAALEKSAKKDSKK---KSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQ 1013
RR+ L++ +++ ++ K E EQ L E ++ + +++++
Sbjct: 471 ----RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEE 526
Query: 1014 QQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKE-----ICEKEKKEL 1068
+ LR EQ + ++R L ++ + +E + +LK+ +E + ++E++
Sbjct: 527 RLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERR 586
Query: 1069 KKKMDKKRQEKITEA-KSKDKSQMEEEKTEMIRSYIQEVV----QYIKRLEEAQSKRQEK 1123
++++ ++++E++ + K ++ ++E+E+ R +E Q + + EE + +RQ++
Sbjct: 587 QQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQ 646
Query: 1124 LVEKHKEIRQQILDEKPKGE 1143
L + +E R+Q L + + E
Sbjct: 647 LRREQQERREQRLKREEEEE 666
Score = 56.2 bits (134), Expect = 2e-07
Identities = 69/345 (20%), Positives = 152/345 (44%), Gaps = 17/345 (4%)
Query: 814 IRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEAR----TTPAENGVNHTTT 869
++++ EQ ++ A L++EE+ +E E + + HT
Sbjct: 831 LQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLY 890
Query: 870 LTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELK-QQKSFVKLQKKHYK 928
P Q Q + + E+ + E E Q EE + QQ+ L+++ K
Sbjct: 891 AKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREK 950
Query: 929 EMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSS------ 982
+ +R ++K L ++ E RRR EK +++ + + E
Sbjct: 951 RRRQERERQYRKDKKLQQKEEQLLGEEPEK--RRRQEREKKYREEEELQQEEEQLLREER 1008
Query: 983 PDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKL 1042
E+ D ++ L+++++++ L R+ QY E+ ++E +LL ++
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER 1068
Query: 1043 TDVAEECQNNQLKKLKEICEKEKKELKKKMDK-KRQEKITEAKSKDKSQMEEE---KTEM 1098
+ Q +K +E+ ++E++ L+++ +K +RQE+ + + +++ Q EEE + E
Sbjct: 1069 ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128
Query: 1099 IRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKGE 1143
+ QE+ + + EE Q + ++ L E+ ++ R+Q L+ + + E
Sbjct: 1129 EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE 1173
Score = 55.5 bits (132), Expect = 3e-07
Identities = 49/268 (18%), Positives = 131/268 (48%), Gaps = 17/268 (6%)
Query: 899 QSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQND 958
Q + E + + ++L++++ + Q+ +E + ++ ++ L +E + +E +++
Sbjct: 381 QQLRREQQLRREQQLRREQQLRREQQLR-REQQLRREQQLRREQQLRREQEEERHEQKHE 439
Query: 959 YLRRRAAL--EKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQL 1016
RR L E+ ++D K+ E + +Q + E ++ + L+++++++
Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ 499
Query: 1017 LNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKR 1076
R++Q E+ ++RE Q+L EE + Q + ++ +E++E ++++ K+
Sbjct: 500 QERREQQLRREQEERRE------QRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE 553
Query: 1077 QEKITEAKSKD---KSQMEEEKTEMIRSYIQEVVQYIKR-----LEEAQSKRQEKLVEKH 1128
+EK E + ++ K + EE + ++++ + Q +KR LE+ + + + +E+
Sbjct: 554 EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613
Query: 1129 KEIRQQILDEKPKGEGSSSFLSETCHED 1156
+ Q++ E+P+ E L E+
Sbjct: 614 ERREQRLKREEPEEERRQQLLKSEEQEE 641
Score = 51.2 bits (121), Expect = 6e-06
Identities = 75/352 (21%), Positives = 154/352 (43%), Gaps = 46/352 (13%)
Query: 821 EQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALH 880
E R +Q EEE+++E + + E P + R E L + Q L
Sbjct: 1069 ETRRRQELERQYRKEEELQQEEE--QLLREEPEKRRRQERERQCREEEELQQEE-EQLLR 1125
Query: 881 SQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEE--LKQQKSFVKLQK--KHYKEMKDLVKR 936
+ + + ++L + E E Q EE L+++ + Q+ + Y+E ++L +
Sbjct: 1126 EE------REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE 1179
Query: 937 HHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAA 996
+ L++E K + + R L++ +K + + S E++ A
Sbjct: 1180 EEQ----LLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAV 1235
Query: 997 LDA---------EMTQKLID--LKDKQQQQ-LLNLRQEQYYSEKYQKREHIKLLIQKLTD 1044
D E ++L D L+D+Q QQ L +L EQ ++ Q+R + + +
Sbjct: 1236 RDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPE 1295
Query: 1045 VA--EECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSY 1102
E + + K+ ++EK+ L+++ ++KR+ + T+ K +++ Q+ +E+ E
Sbjct: 1296 EEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE----- 1350
Query: 1103 IQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP---KGEGSSSFLSE 1151
Q ++R E + R+E+L +H+E ++ L+E+ + E FL E
Sbjct: 1351 -----QPLRRQERDRKFREEEL--RHQEQGRKFLEEEQRLRRQERERKFLKE 1395
Score = 50.4 bits (119), Expect = 1e-05
Identities = 39/198 (19%), Positives = 103/198 (52%), Gaps = 9/198 (4%)
Query: 945 IKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQK 1004
++E + + R + L + +K+ +++ + +E++ E Q+
Sbjct: 790 LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRER-EKELQFLEEEEQLQRRERAQQ 848
Query: 1005 LIDLKDK-QQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEK 1063
L + +D Q+ Q QEQ +K++ + + ++ T A+ QL+K +++ ++
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908
Query: 1064 EKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEK 1123
E++EL+++ +KR+ + E + +++ Q+++E+ +++R +E + ++ E Q ++ +K
Sbjct: 909 EEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLR---EEREKRRRQERERQYRKDKK 965
Query: 1124 LVEKHKEIRQQILDEKPK 1141
L +K +Q+L E+P+
Sbjct: 966 LQQK----EEQLLGEEPE 979
Score = 48.9 bits (115), Expect = 3e-05
Identities = 46/245 (18%), Positives = 127/245 (51%), Gaps = 19/245 (7%)
Query: 895 EDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNE 954
E L + L E+ + EE +QQ+ + Q + ++E ++ K K+ T L KE +
Sbjct: 208 EQLRRRELLELRRKGREEKQQQRR--ERQDRVFQEEEE--KEWRKRETVLRKEE----EK 259
Query: 955 IQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQ 1014
+Q + +R+ L++ ++ K + + + +Q + ++ +K + + +QQ+
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQE 319
Query: 1015 QLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDK 1074
+ R++Q E+ ++R Q+L EE + QL++ +E E+ +++L+++ ++
Sbjct: 320 ER---REQQERREQQEERRE-----QQLRREQEERREQQLRREQEE-ERREQQLRREQEE 370
Query: 1075 KRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQ 1134
+R+E+ + + + + + + + +R ++ ++ ++L Q R+E+ + + +++R++
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRR--EQQLRREQQLRREQQLRREQQLRREQQLRRE 428
Query: 1135 ILDEK 1139
+E+
Sbjct: 429 QEEER 433
Score = 48.5 bits (114), Expect = 4e-05
Identities = 49/266 (18%), Positives = 125/266 (46%), Gaps = 14/266 (5%)
Query: 906 EAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAA 965
E Q ++E ++Q+ + + + ++E + ++R ++ L +E + E++ + R
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKF-REEEQ 1730
Query: 966 LEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYY 1025
L + +++ ++ E + + + ++ ++ D K ++++QL R+EQ
Sbjct: 1731 LRQETEQEQLRRQERYRKILEEEQLRPERE--EQQLRRQERDRKFREEEQLRQEREEQQL 1788
Query: 1026 SEKYQKREHIKLLIQKLTDVAEECQ-NNQLKKLKEICEKEKKELKKKMDKKRQEKITEAK 1084
+ R+ + ++L EE Q Q + K E+E+ +L+++ + RQE+ + +
Sbjct: 1789 RSQESDRKFREE--EQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR 1846
Query: 1085 SKDKSQMEEEKTEMIRSYIQEVVQ-----YIKRLEEAQSKRQEKLVEKHKEIRQQILDEK 1139
++++ +E+ + QE Q ++L E +RQ+K ++H+++ + +
Sbjct: 1847 AEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGE---IKS 1903
Query: 1140 PKGEGSSSFLSETCHEDPSVSPNFTP 1165
+G+G L H+ SV +P
Sbjct: 1904 QEGKGHGRLLEPGTHQFASVPVRSSP 1929
Score = 47.8 bits (112), Expect = 6e-05
Identities = 46/233 (19%), Positives = 112/233 (48%), Gaps = 14/233 (6%)
Query: 911 EELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSA 970
EEL +Q+ + +++ E + L +T + E + E+ LRR+ EK
Sbjct: 171 EELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLE--LRRKGREEKQQ 228
Query: 971 KKDSKK-----KSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQ----QLLNLRQ 1021
++ ++ + E + + ++ L E Q+ +L+++++Q + LR+
Sbjct: 229 QRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRR 288
Query: 1022 EQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKIT 1081
E+ E+ Q+R + Q+L EE + Q ++ +E E+ +++ +++ + R+E+
Sbjct: 289 ERQEEEQQQQRLRRE---QQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE 345
Query: 1082 EAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQ 1134
+ + + + EEE+ E QE + ++L Q R+E+ + + +++R++
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRRE 398
Score = 47.4 bits (111), Expect = 8e-05
Identities = 43/232 (18%), Positives = 116/232 (50%), Gaps = 8/232 (3%)
Query: 902 LTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLR 961
L + E Q + E +++K ++ +++ Y+E ++L + + + + T + E++ Y R
Sbjct: 1026 LQQEEEQLLRE-EREKRRLQERERQYREEEELQQEEEQLLGE--ERETRRRQELERQY-R 1081
Query: 962 RRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQ 1021
+ L++ ++ +++ E ++ L E Q L + ++K+++Q L +
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREE-EELQQEEEQLLREEREKRRRQEL---E 1137
Query: 1022 EQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKIT 1081
QY E+ ++E +LL ++ + Q ++ +E+ ++E++ L+++ +K+RQE+
Sbjct: 1138 RQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERER 1197
Query: 1082 EAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQ 1133
+ + +++ Q ++ K + +++ E+ + R K+ K +E Q
Sbjct: 1198 QYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQ 1249
Score = 47.4 bits (111), Expect = 8e-05
Identities = 66/336 (19%), Positives = 146/336 (43%), Gaps = 38/336 (11%)
Query: 821 EQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALH 880
E+R +Q +EEE+++E E E R E L + Q
Sbjct: 1159 EKRRRQELERQYREEEELQQEE---EQLLREEQEKRRQERERQYREEEELQRQKRKQRYR 1215
Query: 881 SQPAPGSVK---APAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRH 937
+ +K P K E+ ++ + + E+ +Q + ++ ++++ L+
Sbjct: 1216 DEDQRSDLKWQWEPEK-ENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274
Query: 938 HKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAAL 997
++ +E + + ++ + LE+ +K++K++ S + E++
Sbjct: 1275 QERD----REQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREERE---- 1326
Query: 998 DAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKR----EHIKLLIQKLTDVAEEC---- 1049
+ ++ D K ++++QLL R+EQ + + R E ++ Q + EE
Sbjct: 1327 -EKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRR 1385
Query: 1050 QNNQLKKLKEI----CEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQE 1105
Q + K LKE C++ +++L++ D+K +E+ + +++ + E+ + +R +E
Sbjct: 1386 QERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445
Query: 1106 VVQYIKRLEEAQSKRQEKLVEKHKEIR--QQILDEK 1139
K LEE Q RQ E+H++ R +Q+L E+
Sbjct: 1446 R----KFLEEEQQLRQ----ERHRKFREEEQLLQER 1473
Score = 46.6 bits (109), Expect = 1e-04
Identities = 46/238 (19%), Positives = 116/238 (48%), Gaps = 21/238 (8%)
Query: 906 EAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAA 965
E Q ++E ++Q ++ Q++ K ++ ++ + L +E + E + +L+
Sbjct: 1341 EEQLLQEREEQP--LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398
Query: 966 LEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYY 1025
L ++ ++ D EQ L+ + + ++++QQ R+ ++
Sbjct: 1399 LRCQEREQQLRQDR----DRKFREEEQQLSRQERDRK-----FREEEQQVRRQERERKFL 1449
Query: 1026 SEKYQKRE--HIKLLIQK-LTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITE 1082
E+ Q R+ H K ++ L EE Q ++ ++ ++ E+E++ +++ D+K +E+
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELR 1509
Query: 1083 AKSKDKSQMEEE----KTEMIRSYIQEVVQYIKRLEEAQSKRQ--EKLVEKHKEIRQQ 1134
++ ++ +EEE + + R ++QE Q ++R E Q +RQ ++ + +++RQ+
Sbjct: 1510 SQEPERKFLEEEQQLHRQQRQRKFLQE-EQQLRRQERGQQRRQDRDRKFREEEQLRQE 1566
Score = 46.2 bits (108), Expect = 2e-04
Identities = 48/248 (19%), Positives = 121/248 (48%), Gaps = 30/248 (12%)
Query: 892 AKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTK 951
A+ E L E E EE +++ ++L++K +E + + ++ D + +
Sbjct: 188 AEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQ----QQRRERQDRVFQE--- 240
Query: 952 YNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDK 1011
E + ++ +R L K ++ K + E E+ L L+ + ++ +++
Sbjct: 241 --EEEKEWRKRETVLRK---EEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQ 295
Query: 1012 QQQQL-----LNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKK 1066
QQQ+L L +QE+ E+ ++R Q+ + EE + QL++ +E E+ ++
Sbjct: 296 QQQRLRREQQLRRKQEEERREQQEERRE----QQERREQQEERREQQLRREQE--ERREQ 349
Query: 1067 ELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVE 1126
+L+++ +++R+E + + Q EE + + +R ++ ++ ++L Q R+E+ +
Sbjct: 350 QLRREQEEERRE-----QQLRREQEEERREQQLRR--EQQLRREQQLRREQQLRREQQLR 402
Query: 1127 KHKEIRQQ 1134
+ +++R++
Sbjct: 403 REQQLRRE 410
Score = 45.8 bits (107), Expect = 2e-04
Identities = 47/243 (19%), Positives = 122/243 (50%), Gaps = 13/243 (5%)
Query: 904 EVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRR 963
E E + +E ++++ + Q++ +E + ++ ++ L +E + E Q +
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE 370
Query: 964 AALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQ 1023
E+ +++ + + E EQ L + ++ ++ +++Q ++ LR+EQ
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRREQQLRR-EQQLRREQQLRREQQLRREQQLRREQ 429
Query: 1024 YYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEI----CEKEKKELKKKMDKKRQEK 1079
E+++++ + Q+L EE + + LK+ +E E+ K++LK+ +++R+E+
Sbjct: 430 E-EERHEQKHEQERREQRLKREQEE-RRDWLKREEETERHEQERRKQQLKRDQEEERRER 487
Query: 1080 ITEAKSKDKSQMEEEKTEMIRSYIQE-VVQYIKRLEEAQSKRQ-----EKLVEKHKEIRQ 1133
+ + +++ + +E + + +R +E Q +KR EE + +Q ++L + +E R+
Sbjct: 488 WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE 547
Query: 1134 QIL 1136
Q+L
Sbjct: 548 QLL 550
Score = 45.8 bits (107), Expect = 2e-04
Identities = 43/241 (17%), Positives = 119/241 (49%), Gaps = 18/241 (7%)
Query: 911 EELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLR--RRAALEK 968
E +Q + KLQ+K + + + ++ ++ + + + + LR R +
Sbjct: 955 ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014
Query: 969 SAKKDSKKKSEPSSPDHGSSTIEQDLAAL-DAEMTQKLIDLKDKQQQQLLN----LRQEQ 1023
++ +KK E + E++ L + E + + ++++QLL R+ Q
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQ 1074
Query: 1024 YYSEKYQKREHI-----KLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQE 1078
+Y+K E + +LL ++ + + Q ++ +E+ ++E++ L+++ +K+R++
Sbjct: 1075 ELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQ 1134
Query: 1079 KITEAKSKDKSQMEEEKTEMIRS-----YIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQ 1133
++ E + +++ ++++E+ +++R QE+ + + EE Q + ++ L E+ ++ RQ
Sbjct: 1135 EL-ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQ 1193
Query: 1134 Q 1134
+
Sbjct: 1194 E 1194
Score = 44.7 bits (104), Expect = 5e-04
Identities = 46/242 (19%), Positives = 114/242 (47%), Gaps = 11/242 (4%)
Query: 911 EELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSA 970
EE K Q+ + Q++ +E + L K ++ +E + ++ + RR E+
Sbjct: 256 EEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR 315
Query: 971 KKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQ 1030
++ +++ + + EQ L E ++ + + +++++ LR+EQ + +
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ----EEE 371
Query: 1031 KREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQ 1090
+RE Q+L + + QL++ +++ + +++L+++ +R++++ + + Q
Sbjct: 372 RREQQLRREQQLRREQQLRREQQLRREQQL--RREQQLRREQQLRREQQLRREQQLRREQ 429
Query: 1091 MEEEKTEMIRSYIQEVVQYIKRLEEAQS---KRQEKLVEKHKEIRQQILDEKPKGEGSSS 1147
EEE+ E + + Q +KR +E + KR+E+ +E R+Q L + E
Sbjct: 430 -EEERHEQ-KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER 487
Query: 1148 FL 1149
+L
Sbjct: 488 WL 489
Score = 43.5 bits (101), Expect = 0.001
Identities = 50/245 (20%), Positives = 104/245 (42%), Gaps = 26/245 (10%)
Query: 906 EAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAA 965
E Q E +QQ+ L ++ KE + +R +K ++E + RR A
Sbjct: 795 ERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE--------EEQLQRRERA 846
Query: 966 LEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDK--------QQQQLL 1017
+ ++D ++ + ++ L+ E ++ L K ++QQLL
Sbjct: 847 QQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL 906
Query: 1018 NLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELK-------K 1070
+E+ E+ +KR + Q + E+ Q + + L+E EK +++ + K
Sbjct: 907 QEEEEELQREEREKRRRQEQERQYREE--EQLQQEEEQLLREEREKRRRQERERQYRKDK 964
Query: 1071 KMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQ-EKLVEKHK 1129
K+ +K ++ + E K + Q E+K QE Q ++ E + +++ E+ K
Sbjct: 965 KLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKD 1024
Query: 1130 EIRQQ 1134
E++Q+
Sbjct: 1025 ELQQE 1029
Score = 42.7 bits (99), Expect = 0.002
Identities = 50/257 (19%), Positives = 116/257 (45%), Gaps = 28/257 (10%)
Query: 906 EAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHH---KKTTDLIKEHTTKYNEIQ---NDY 959
E Q E ++++ +L+++ + + ++R ++ L +E + E Q
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382
Query: 960 LRRRAAL--EKSAKKDSKKKSEPSSPDHGSSTIEQDLAA---LDAEMTQKLIDLKDKQQQ 1014
LRR L E+ +++ + + E EQ L L E ++ + K +Q++
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER 442
Query: 1015 QLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDK 1074
+ L++EQ + KRE + Q + ++LK E+E++E K+++
Sbjct: 443 REQRLKREQEERRDWLKREE---------ETERHEQERRKQQLKRDQEEERRERWLKLEE 493
Query: 1075 KRQEKITEAKSKDKSQMEEEKTEM------IRSYIQEVVQYIKRLEEAQSKRQEKLV--E 1126
+ + + E + + + +EE+ E +Q+ ++ ++L Q +R+E+L+ E
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE 553
Query: 1127 KHKEIRQQILDEKPKGE 1143
+ K + Q+ +++ K E
Sbjct: 554 EEKRLEQERREQRLKRE 570
Score = 40.0 bits (92), Expect = 0.013
Identities = 46/241 (19%), Positives = 119/241 (49%), Gaps = 22/241 (9%)
Query: 904 EVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRR 963
++E + +E K++ + +K+ +E ++ KR ++T +E E + LRR+
Sbjct: 1298 QLEREEQKEAKRRDRKSQEEKQLLREERE-EKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356
Query: 964 AALEKSAKKDSK-KKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQE 1022
++D K ++ E + G +E++ E +K + K++QQL +E
Sbjct: 1357 -------ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFL----KEEQQLRCQERE 1405
Query: 1023 QYYSE----KYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQE 1078
Q + K+++ E ++ EE Q + ++ + +E+++L+++ +K +E
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE 1465
Query: 1079 KITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDE 1138
+ + +++ Q+ ++ + R +++E Q ++R E + R+++L + +E ++ L+E
Sbjct: 1466 EEQLLQEREEQQLHRQERD--RKFLEE-EQQLRRQERDRKFREQEL--RSQEPERKFLEE 1520
Query: 1139 K 1139
+
Sbjct: 1521 E 1521
Score = 39.7 bits (91), Expect = 0.017
Identities = 42/242 (17%), Positives = 116/242 (47%), Gaps = 17/242 (7%)
Query: 899 QSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQND 958
+ +L E E Q + ++ + F++ + + ++ ++ RH + +E E +
Sbjct: 1625 EQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRK--FREEEQLLQEGEEQ 1682
Query: 959 YLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLN 1018
LRR+ K +++ + + + E+ + ++ ++ ++ K ++++QL
Sbjct: 1683 QLRRQERDRKFREEEQQLRRQER---------ERKFLQEEQQLRRQELERKFREEEQL-- 1731
Query: 1019 LRQEQYYSEKYQKREHIKLLIQK-LTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQ 1077
RQE + ++ + K+L ++ L EE Q + ++ ++ E+E+ +++ + R
Sbjct: 1732 -RQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRS 1790
Query: 1078 EKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILD 1137
++ ++ K +++ Q+ +E+ E Q +Y E+ Q + QE+ + + ++ RQ +
Sbjct: 1791 QE-SDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERD-RQYRAE 1848
Query: 1138 EK 1139
E+
Sbjct: 1849 EQ 1850
Score = 38.5 bits (88), Expect = 0.038
Identities = 49/252 (19%), Positives = 119/252 (47%), Gaps = 22/252 (8%)
Query: 904 EVEAQTIEELKQQKSFVKLQKKHYKE-MKDLVKRHH---KKTTDLIKEHTTKYNE-IQND 958
E Q + +Q++ +L+++ +E ++ +KR H ++ +L +E + E I++
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSR 700
Query: 959 YLRRRAALEKSAK-KDSKKKSEPSSPDHGSSTIEQD--LAALDAEMTQKLIDLKDKQQQQ 1015
+ + LE A + SK S P + EQ+ ++E+ + + +QQQ+
Sbjct: 701 IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQE 760
Query: 1016 LLNLR------QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELK 1069
R Q + SE+ ++R + +++ + + Q ++ + + E+E+KE +
Sbjct: 761 EEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQR 820
Query: 1070 KKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHK 1129
++ ++R+ K+ +EEE+ R Q++ + L+E Q +R+ + + +
Sbjct: 821 RRQRRERE--------KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ 872
Query: 1130 EIRQQILDEKPK 1141
+ R Q+ +E+ +
Sbjct: 873 KWRWQLEEERKR 884
Score = 36.6 bits (83), Expect = 0.14
Identities = 55/232 (23%), Positives = 108/232 (46%), Gaps = 39/232 (16%)
Query: 913 LKQQKSFVKLQKKHYKEMKDLVK-RHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAK 971
L++QK V+ Q++ K M+D + R + L +E K+ E ++ L + ++ +
Sbjct: 1583 LEEQK--VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE--DEQLLQEREEQQLHR 1638
Query: 972 KDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQK 1031
++ +K P EQ L + D K ++++QLL +EQ + +
Sbjct: 1639 QERDRKFLEEEPQLRRQEREQQL--------RHDRDRKFREEEQLLQEGEEQQLRRQERD 1690
Query: 1032 REHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQM 1091
R+ + + QL++ E+E+K L+++ +RQE E K +++ Q+
Sbjct: 1691 RKFRE-------------EEQQLRRQ----ERERKFLQEEQQLRRQE--LERKFREEEQL 1731
Query: 1092 EEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKGE 1143
+E TE + QE +Y K LEE Q + + + +++R+Q D K + E
Sbjct: 1732 RQE-TEQEQLRRQE--RYRKILEEEQLRPE----REEQQLRRQERDRKFREE 1776
Score = 33.9 bits (76), Expect = 0.93
Identities = 40/252 (15%), Positives = 116/252 (46%), Gaps = 18/252 (7%)
Query: 899 QSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVK-----RHHKKTTDLIKEHTTKYN 953
+ +L E E Q + ++ + F + + +H ++ + ++ R ++ +KE
Sbjct: 1342 EQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRC 1401
Query: 954 EIQNDYLR--RRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLID---L 1008
+ + LR R + ++ S+++ + + Q+ E Q+L
Sbjct: 1402 QEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHR 1461
Query: 1009 KDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLK-EICEKEKKE 1067
K ++++QLL R+EQ + ++E + +++ + + ++ + ++ + E E+K
Sbjct: 1462 KFREEEQLLQEREEQ----QLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKF 1517
Query: 1068 LKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEK 1127
L+++ RQ++ + +++ +E+ + R Q+ + + E+ + +R+E+ + +
Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR---QDRDRKFREEEQLRQEREEQQLSR 1574
Query: 1128 HKEIRQQILDEK 1139
+ R+ L+E+
Sbjct: 1575 QERDRKFRLEEQ 1586
>gi|28460688 taxilin [Homo sapiens]
Length = 546
Score = 62.4 bits (150), Expect = 2e-09
Identities = 72/320 (22%), Positives = 139/320 (43%), Gaps = 24/320 (7%)
Query: 841 EADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKT-----E 895
EA P E E PS+A PA ++ P+ P A G+++ ++ E
Sbjct: 24 EAGP-EGAQERPSQA--APAVEAEGPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQLE 80
Query: 896 DLIQSVLTE----------VEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLI 945
D++ + + + + E +KS + + E +V + +
Sbjct: 81 DILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDP 140
Query: 946 KEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKL 1005
+ ++ D RR +K AK K+ + + ST E+ LAAL + + L
Sbjct: 141 NTEEIRQSDEVGDRDHRRPQEKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELL 200
Query: 1006 IDLKDKQQQ-QLLNLRQEQYYSEKYQKR-EHIKLLI--QKLTDVAEECQNNQLKKLKEIC 1061
+ ++ Q+Q +LL +Q Q EK R EH K ++ KL + E Q + +E
Sbjct: 201 EEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGV 260
Query: 1062 EKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQ 1121
++ ++E +K+ + ++T + + + E+ +R E+ + +K+L E R+
Sbjct: 261 QRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELRE 320
Query: 1122 EKL--VEKHKEIRQQILDEK 1139
E + V KHK+++QQ++D K
Sbjct: 321 EHIDKVFKHKDLQQQLVDAK 340
Score = 51.6 bits (122), Expect = 4e-06
Identities = 65/264 (24%), Positives = 118/264 (44%), Gaps = 45/264 (17%)
Query: 917 KSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKK 976
+S + ++H + +K+ + ++ + KE T+ + ND + +E+ +++SK
Sbjct: 242 ESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSHFQVTLNDI---QLQMEQHNERNSKL 298
Query: 977 KSEPSS-PDHGSSTIEQ--------DLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSE 1027
+ E + IEQ D ++ Q+L+D K +Q Q++L +E++ E
Sbjct: 299 RQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQAQEMLKEAEERHQRE 358
Query: 1028 K-----------------YQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKK 1070
K Q+ H+K + T+ EE QN L K E+ K+E++K
Sbjct: 359 KDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNT-LSKSSEVFTTFKQEMEK 417
Query: 1071 KMDK-KRQEKIT-------EAKSKDKSQMEEEKTEMIRSYIQEVVQY-IKRLEEAQSKRQ 1121
K K+ EK T E+ +K +M EEKT +R E +Q I+RLE K
Sbjct: 418 MTKKIKKLEKETTMYRSRWESSNKALLEMAEEKT--VRDKELEGLQVKIQRLE----KLC 471
Query: 1122 EKLVEKHKEIRQQILDEKPKGEGS 1145
L + ++ +++ D G+GS
Sbjct: 472 RALQTERNDLNKRVQDLSAGGQGS 495
>gi|33946313 ninein isoform 4 [Homo sapiens]
Length = 2096
Score = 62.0 bits (149), Expect = 3e-09
Identities = 58/252 (23%), Positives = 113/252 (44%), Gaps = 8/252 (3%)
Query: 904 EVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRR 963
E+E + KQ V KK + MK +RH +T L K+ + NEI L+ +
Sbjct: 634 ELEDKVRHYEKQLDETVVSCKKAQENMK---QRHENETHTLEKQISDLKNEIAE--LQGQ 688
Query: 964 AALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQ 1023
AA+ K A ++ + E E+ + Q ++LK + Q + +E+
Sbjct: 689 AAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFERER 748
Query: 1024 YYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEA 1083
E Q + ++ LT E+ QL L E EK+EL+K++ +K Q ++ E
Sbjct: 749 ---EGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEG 805
Query: 1084 KSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKGE 1143
+ K +++ +++ + + + +R E A + + ++ K++++Q +EK + E
Sbjct: 806 REKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWE 865
Query: 1144 GSSSFLSETCHE 1155
L++ C E
Sbjct: 866 FEKDELTQECAE 877
Score = 45.4 bits (106), Expect = 3e-04
Identities = 56/261 (21%), Positives = 114/261 (43%), Gaps = 31/261 (11%)
Query: 893 KTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKY 952
K + +S L +E + +ELK + + +K ++ KD + + + +L+KE +
Sbjct: 830 KVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKRE 889
Query: 953 NEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQ 1012
+ R LEK+ K+ S +E+ D E L ++ + Q
Sbjct: 890 KTTSLVLTQEREMLEKTYKEHL-----------NSMVVERQQLLQDLE---DLRNVSETQ 935
Query: 1013 QQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKM 1072
Q L + E S K + RE ++L Q +E+ + +L++L+ ++E++E+ K+
Sbjct: 936 QSLLSDQILELKSSHKRELREREEVLCQ--AGASEQLASQRLERLEMEHDQERQEMMSKL 993
Query: 1073 --DKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKE 1130
+ + E +++++M E ++S I+E+ Q L QS
Sbjct: 994 LAMENIHKATCETADRERAEMSTE-ISRLQSKIKEMQQATSPLSMLQSG----------- 1041
Query: 1131 IRQQILDEKPKGEGSSSFLSE 1151
Q I +E+ +G+G+ S L +
Sbjct: 1042 -CQVIGEEEVEGDGALSLLQQ 1061
Score = 43.5 bits (101), Expect = 0.001
Identities = 52/230 (22%), Positives = 102/230 (44%), Gaps = 30/230 (13%)
Query: 913 LKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKK 972
L++ + + Q KH++ + + +KT ++E T K E ++++ L K+
Sbjct: 1437 LEENTTLLGFQDKHFQHQATIAELELEKTK--LQELTRKLKERVTILVKQKDVLSHGEKE 1494
Query: 973 DSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLK---DKQQQQLLNLRQEQYYSEKY 1029
+ K + DL +EM QK+ L+ +K QQ+ LR E +
Sbjct: 1495 EELK------------AMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE 1542
Query: 1030 QKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKS 1089
++KL Q +K + + K++ +KM + +++I+E K K++
Sbjct: 1543 DSISNLKL------GTLNGSQEEMWQKTETV--KQENAAVQKMVENLKKQISELKIKNQ- 1593
Query: 1090 QMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEK 1139
Q++ E TE+ Q+ Q ++L+E + E L +K KE L+E+
Sbjct: 1594 QLDLENTELS----QKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEER 1639
Score = 36.6 bits (83), Expect = 0.14
Identities = 43/217 (19%), Positives = 104/217 (47%), Gaps = 24/217 (11%)
Query: 911 EELKQQKSFVKLQKKHYKEMKDLVKRHHKKT---TDLIKEHTTKYNEIQNDYLRRRAALE 967
EELK +++ ++ +L++ +K +++ T NE ++ +
Sbjct: 1495 EELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE-EDSISNLKLGTL 1553
Query: 968 KSAKKDSKKKSEPSSPDHGSSTIEQDLAALDA---EMTQKLIDLKDKQQQQLLNLRQEQY 1024
++++ +K+E T++Q+ AA+ + +++ +LK K QQ L+L +
Sbjct: 1554 NGSQEEMWQKTE---------TVKQENAAVQKMVENLKKQISELKIKNQQ--LDLENTEL 1602
Query: 1025 YSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAK 1084
+ Q +E ++ L Q+LT++ + + E E+EK LK+++++ + + T
Sbjct: 1603 SQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLV- 1661
Query: 1085 SKDKSQMEEEKTEM-IRSYIQEVVQYIKRLEEAQSKR 1120
S +E E +E+ I+++I + ++ + E + K+
Sbjct: 1662 ----SSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1694
Score = 32.7 bits (73), Expect = 2.1
Identities = 32/118 (27%), Positives = 54/118 (45%), Gaps = 11/118 (9%)
Query: 1019 LRQEQYYSEKYQKREHIKLLIQKLTD----VAEECQNNQLKKLKEICEKEKKELKKKMDK 1074
+R+++ K E +K L+ D E L+KL E ++ LK ++ K
Sbjct: 386 VREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRK 445
Query: 1075 KRQEKITEAKSKDKSQMEEE----KTE--MIRSYIQEVVQYIKRLEEAQSKRQEKLVE 1126
+R E+I + K + ++E+E KTE IR + ++ RLE + EKL E
Sbjct: 446 ER-EQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAE 502
>gi|33946321 ninein isoform 5 [Homo sapiens]
Length = 2090
Score = 62.0 bits (149), Expect = 3e-09
Identities = 58/252 (23%), Positives = 113/252 (44%), Gaps = 8/252 (3%)
Query: 904 EVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRR 963
E+E + KQ V KK + MK +RH +T L K+ + NEI L+ +
Sbjct: 628 ELEDKVRHYEKQLDETVVSCKKAQENMK---QRHENETHTLEKQISDLKNEIAE--LQGQ 682
Query: 964 AALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQ 1023
AA+ K A ++ + E E+ + Q ++LK + Q + +E+
Sbjct: 683 AAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFERER 742
Query: 1024 YYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEA 1083
E Q + ++ LT E+ QL L E EK+EL+K++ +K Q ++ E
Sbjct: 743 ---EGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEG 799
Query: 1084 KSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKGE 1143
+ K +++ +++ + + + +R E A + + ++ K++++Q +EK + E
Sbjct: 800 REKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWE 859
Query: 1144 GSSSFLSETCHE 1155
L++ C E
Sbjct: 860 FEKDELTQECAE 871
Score = 45.4 bits (106), Expect = 3e-04
Identities = 56/261 (21%), Positives = 114/261 (43%), Gaps = 31/261 (11%)
Query: 893 KTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKY 952
K + +S L +E + +ELK + + +K ++ KD + + + +L+KE +
Sbjct: 824 KVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKRE 883
Query: 953 NEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQ 1012
+ R LEK+ K+ S +E+ D E L ++ + Q
Sbjct: 884 KTTSLVLTQEREMLEKTYKEHL-----------NSMVVERQQLLQDLE---DLRNVSETQ 929
Query: 1013 QQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKM 1072
Q L + E S K + RE ++L Q +E+ + +L++L+ ++E++E+ K+
Sbjct: 930 QSLLSDQILELKSSHKRELREREEVLCQ--AGASEQLASQRLERLEMEHDQERQEMMSKL 987
Query: 1073 --DKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKE 1130
+ + E +++++M E ++S I+E+ Q L QS
Sbjct: 988 LAMENIHKATCETADRERAEMSTE-ISRLQSKIKEMQQATSPLSMLQSG----------- 1035
Query: 1131 IRQQILDEKPKGEGSSSFLSE 1151
Q I +E+ +G+G+ S L +
Sbjct: 1036 -CQVIGEEEVEGDGALSLLQQ 1055
Score = 43.5 bits (101), Expect = 0.001
Identities = 52/230 (22%), Positives = 102/230 (44%), Gaps = 30/230 (13%)
Query: 913 LKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKK 972
L++ + + Q KH++ + + +KT ++E T K E ++++ L K+
Sbjct: 1431 LEENTTLLGFQDKHFQHQATIAELELEKTK--LQELTRKLKERVTILVKQKDVLSHGEKE 1488
Query: 973 DSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLK---DKQQQQLLNLRQEQYYSEKY 1029
+ K + DL +EM QK+ L+ +K QQ+ LR E +
Sbjct: 1489 EELK------------AMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE 1536
Query: 1030 QKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKS 1089
++KL Q +K + + K++ +KM + +++I+E K K++
Sbjct: 1537 DSISNLKL------GTLNGSQEEMWQKTETV--KQENAAVQKMVENLKKQISELKIKNQ- 1587
Query: 1090 QMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEK 1139
Q++ E TE+ Q+ Q ++L+E + E L +K KE L+E+
Sbjct: 1588 QLDLENTELS----QKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEER 1633
Score = 36.6 bits (83), Expect = 0.14
Identities = 43/217 (19%), Positives = 104/217 (47%), Gaps = 24/217 (11%)
Query: 911 EELKQQKSFVKLQKKHYKEMKDLVKRHHKKT---TDLIKEHTTKYNEIQNDYLRRRAALE 967
EELK +++ ++ +L++ +K +++ T NE ++ +
Sbjct: 1489 EELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE-EDSISNLKLGTL 1547
Query: 968 KSAKKDSKKKSEPSSPDHGSSTIEQDLAALDA---EMTQKLIDLKDKQQQQLLNLRQEQY 1024
++++ +K+E T++Q+ AA+ + +++ +LK K QQ L+L +
Sbjct: 1548 NGSQEEMWQKTE---------TVKQENAAVQKMVENLKKQISELKIKNQQ--LDLENTEL 1596
Query: 1025 YSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAK 1084
+ Q +E ++ L Q+LT++ + + E E+EK LK+++++ + + T
Sbjct: 1597 SQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLV- 1655
Query: 1085 SKDKSQMEEEKTEM-IRSYIQEVVQYIKRLEEAQSKR 1120
S +E E +E+ I+++I + ++ + E + K+
Sbjct: 1656 ----SSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1688
Score = 32.7 bits (73), Expect = 2.1
Identities = 32/118 (27%), Positives = 54/118 (45%), Gaps = 11/118 (9%)
Query: 1019 LRQEQYYSEKYQKREHIKLLIQKLTD----VAEECQNNQLKKLKEICEKEKKELKKKMDK 1074
+R+++ K E +K L+ D E L+KL E ++ LK ++ K
Sbjct: 380 VREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRK 439
Query: 1075 KRQEKITEAKSKDKSQMEEE----KTE--MIRSYIQEVVQYIKRLEEAQSKRQEKLVE 1126
+R E+I + K + ++E+E KTE IR + ++ RLE + EKL E
Sbjct: 440 ER-EQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAE 496
>gi|148536871 ninein isoform 1 [Homo sapiens]
Length = 2046
Score = 62.0 bits (149), Expect = 3e-09
Identities = 58/252 (23%), Positives = 113/252 (44%), Gaps = 8/252 (3%)
Query: 904 EVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRR 963
E+E + KQ V KK + MK +RH +T L K+ + NEI L+ +
Sbjct: 628 ELEDKVRHYEKQLDETVVSCKKAQENMK---QRHENETHTLEKQISDLKNEIAE--LQGQ 682
Query: 964 AALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQ 1023
AA+ K A ++ + E E+ + Q ++LK + Q + +E+
Sbjct: 683 AAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFERER 742
Query: 1024 YYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEA 1083
E Q + ++ LT E+ QL L E EK+EL+K++ +K Q ++ E
Sbjct: 743 ---EGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEG 799
Query: 1084 KSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKGE 1143
+ K +++ +++ + + + +R E A + + ++ K++++Q +EK + E
Sbjct: 800 REKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWE 859
Query: 1144 GSSSFLSETCHE 1155
L++ C E
Sbjct: 860 FEKDELTQECAE 871
Score = 45.4 bits (106), Expect = 3e-04
Identities = 56/261 (21%), Positives = 114/261 (43%), Gaps = 31/261 (11%)
Query: 893 KTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKY 952
K + +S L +E + +ELK + + +K ++ KD + + + +L+KE +
Sbjct: 824 KVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKRE 883
Query: 953 NEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQ 1012
+ R LEK+ K+ S +E+ D E L ++ + Q
Sbjct: 884 KTTSLVLTQEREMLEKTYKEHL-----------NSMVVERQQLLQDLE---DLRNVSETQ 929
Query: 1013 QQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKM 1072
Q L + E S K + RE ++L Q +E+ + +L++L+ ++E++E+ K+
Sbjct: 930 QSLLSDQILELKSSHKRELREREEVLCQ--AGASEQLASQRLERLEMEHDQERQEMMSKL 987
Query: 1073 --DKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKE 1130
+ + E +++++M E ++S I+E+ Q L QS
Sbjct: 988 LAMENIHKATCETADRERAEMSTE-ISRLQSKIKEMQQATSPLSMLQSG----------- 1035
Query: 1131 IRQQILDEKPKGEGSSSFLSE 1151
Q I +E+ +G+G+ S L +
Sbjct: 1036 -CQVIGEEEVEGDGALSLLQQ 1055
Score = 43.5 bits (101), Expect = 0.001
Identities = 52/230 (22%), Positives = 102/230 (44%), Gaps = 30/230 (13%)
Query: 913 LKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKK 972
L++ + + Q KH++ + + +KT ++E T K E ++++ L K+
Sbjct: 1431 LEENTTLLGFQDKHFQHQATIAELELEKTK--LQELTRKLKERVTILVKQKDVLSHGEKE 1488
Query: 973 DSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLK---DKQQQQLLNLRQEQYYSEKY 1029
+ K + DL +EM QK+ L+ +K QQ+ LR E +
Sbjct: 1489 EELK------------AMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE 1536
Query: 1030 QKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKS 1089
++KL Q +K + + K++ +KM + +++I+E K K++
Sbjct: 1537 DSISNLKL------GTLNGSQEEMWQKTETV--KQENAAVQKMVENLKKQISELKIKNQ- 1587
Query: 1090 QMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEK 1139
Q++ E TE+ Q+ Q ++L+E + E L +K KE L+E+
Sbjct: 1588 QLDLENTELS----QKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEER 1633
Score = 36.6 bits (83), Expect = 0.14
Identities = 43/217 (19%), Positives = 104/217 (47%), Gaps = 24/217 (11%)
Query: 911 EELKQQKSFVKLQKKHYKEMKDLVKRHHKKT---TDLIKEHTTKYNEIQNDYLRRRAALE 967
EELK +++ ++ +L++ +K +++ T NE ++ +
Sbjct: 1489 EELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE-EDSISNLKLGTL 1547
Query: 968 KSAKKDSKKKSEPSSPDHGSSTIEQDLAALDA---EMTQKLIDLKDKQQQQLLNLRQEQY 1024
++++ +K+E T++Q+ AA+ + +++ +LK K QQ L+L +
Sbjct: 1548 NGSQEEMWQKTE---------TVKQENAAVQKMVENLKKQISELKIKNQQ--LDLENTEL 1596
Query: 1025 YSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAK 1084
+ Q +E ++ L Q+LT++ + + E E+EK LK+++++ + + T
Sbjct: 1597 SQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLV- 1655
Query: 1085 SKDKSQMEEEKTEM-IRSYIQEVVQYIKRLEEAQSKR 1120
S +E E +E+ I+++I + ++ + E + K+
Sbjct: 1656 ----SSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1688
Score = 32.7 bits (73), Expect = 2.1
Identities = 32/118 (27%), Positives = 54/118 (45%), Gaps = 11/118 (9%)
Query: 1019 LRQEQYYSEKYQKREHIKLLIQKLTD----VAEECQNNQLKKLKEICEKEKKELKKKMDK 1074
+R+++ K E +K L+ D E L+KL E ++ LK ++ K
Sbjct: 380 VREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRK 439
Query: 1075 KRQEKITEAKSKDKSQMEEE----KTE--MIRSYIQEVVQYIKRLEEAQSKRQEKLVE 1126
+R E+I + K + ++E+E KTE IR + ++ RLE + EKL E
Sbjct: 440 ER-EQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAE 496
>gi|148536869 ninein isoform 2 [Homo sapiens]
Length = 2133
Score = 62.0 bits (149), Expect = 3e-09
Identities = 58/252 (23%), Positives = 113/252 (44%), Gaps = 8/252 (3%)
Query: 904 EVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRR 963
E+E + KQ V KK + MK +RH +T L K+ + NEI L+ +
Sbjct: 628 ELEDKVRHYEKQLDETVVSCKKAQENMK---QRHENETHTLEKQISDLKNEIAE--LQGQ 682
Query: 964 AALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQ 1023
AA+ K A ++ + E E+ + Q ++LK + Q + +E+
Sbjct: 683 AAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFERER 742
Query: 1024 YYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEA 1083
E Q + ++ LT E+ QL L E EK+EL+K++ +K Q ++ E
Sbjct: 743 ---EGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEG 799
Query: 1084 KSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKGE 1143
+ K +++ +++ + + + +R E A + + ++ K++++Q +EK + E
Sbjct: 800 REKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWE 859
Query: 1144 GSSSFLSETCHE 1155
L++ C E
Sbjct: 860 FEKDELTQECAE 871
Score = 45.4 bits (106), Expect = 3e-04
Identities = 56/261 (21%), Positives = 114/261 (43%), Gaps = 31/261 (11%)
Query: 893 KTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKY 952
K + +S L +E + +ELK + + +K ++ KD + + + +L+KE +
Sbjct: 824 KVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKRE 883
Query: 953 NEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQ 1012
+ R LEK+ K+ S +E+ D E L ++ + Q
Sbjct: 884 KTTSLVLTQEREMLEKTYKEHL-----------NSMVVERQQLLQDLE---DLRNVSETQ 929
Query: 1013 QQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKM 1072
Q L + E S K + RE ++L Q +E+ + +L++L+ ++E++E+ K+
Sbjct: 930 QSLLSDQILELKSSHKRELREREEVLCQ--AGASEQLASQRLERLEMEHDQERQEMMSKL 987
Query: 1073 --DKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKE 1130
+ + E +++++M E ++S I+E+ Q L QS
Sbjct: 988 LAMENIHKATCETADRERAEMSTE-ISRLQSKIKEMQQATSPLSMLQSG----------- 1035
Query: 1131 IRQQILDEKPKGEGSSSFLSE 1151
Q I +E+ +G+G+ S L +
Sbjct: 1036 -CQVIGEEEVEGDGALSLLQQ 1055
Score = 43.5 bits (101), Expect = 0.001
Identities = 52/230 (22%), Positives = 102/230 (44%), Gaps = 30/230 (13%)
Query: 913 LKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKK 972
L++ + + Q KH++ + + +KT ++E T K E ++++ L K+
Sbjct: 1431 LEENTTLLGFQDKHFQHQATIAELELEKTK--LQELTRKLKERVTILVKQKDVLSHGEKE 1488
Query: 973 DSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLK---DKQQQQLLNLRQEQYYSEKY 1029
+ K + DL +EM QK+ L+ +K QQ+ LR E +
Sbjct: 1489 EELK------------AMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEE 1536
Query: 1030 QKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKS 1089
++KL Q +K + + K++ +KM + +++I+E K K++
Sbjct: 1537 DSISNLKL------GTLNGSQEEMWQKTETV--KQENAAVQKMVENLKKQISELKIKNQ- 1587
Query: 1090 QMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEK 1139
Q++ E TE+ Q+ Q ++L+E + E L +K KE L+E+
Sbjct: 1588 QLDLENTELS----QKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEER 1633
Score = 36.6 bits (83), Expect = 0.14
Identities = 43/217 (19%), Positives = 104/217 (47%), Gaps = 24/217 (11%)
Query: 911 EELKQQKSFVKLQKKHYKEMKDLVKRHHKKT---TDLIKEHTTKYNEIQNDYLRRRAALE 967
EELK +++ ++ +L++ +K +++ T NE ++ +
Sbjct: 1489 EELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE-EDSISNLKLGTL 1547
Query: 968 KSAKKDSKKKSEPSSPDHGSSTIEQDLAALDA---EMTQKLIDLKDKQQQQLLNLRQEQY 1024
++++ +K+E T++Q+ AA+ + +++ +LK K QQ L+L +
Sbjct: 1548 NGSQEEMWQKTE---------TVKQENAAVQKMVENLKKQISELKIKNQQ--LDLENTEL 1596
Query: 1025 YSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAK 1084
+ Q +E ++ L Q+LT++ + + E E+EK LK+++++ + + T
Sbjct: 1597 SQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLV- 1655
Query: 1085 SKDKSQMEEEKTEM-IRSYIQEVVQYIKRLEEAQSKR 1120
S +E E +E+ I+++I + ++ + E + K+
Sbjct: 1656 ----SSLEAELSEVKIQTHIVQQENHLLKDELEKMKQ 1688
Score = 32.7 bits (73), Expect = 2.1
Identities = 32/118 (27%), Positives = 54/118 (45%), Gaps = 11/118 (9%)
Query: 1019 LRQEQYYSEKYQKREHIKLLIQKLTD----VAEECQNNQLKKLKEICEKEKKELKKKMDK 1074
+R+++ K E +K L+ D E L+KL E ++ LK ++ K
Sbjct: 380 VREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRK 439
Query: 1075 KRQEKITEAKSKDKSQMEEE----KTE--MIRSYIQEVVQYIKRLEEAQSKRQEKLVE 1126
+R E+I + K + ++E+E KTE IR + ++ RLE + EKL E
Sbjct: 440 ER-EQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAE 496
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,887,943
Number of Sequences: 37866
Number of extensions: 2229487
Number of successful extensions: 20893
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 281
Number of HSP's successfully gapped in prelim test: 1107
Number of HSP's that attempted gapping in prelim test: 11965
Number of HSP's gapped (non-prelim): 6165
length of query: 1173
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1060
effective length of database: 13,968,660
effective search space: 14806779600
effective search space used: 14806779600
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.