Search of human proteins with 32484977

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|32484977 angiomotin like 2 [Homo sapiens]
         (780 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|32484977 angiomotin like 2 [Homo sapiens]                         1520   0.0  
gi|22027646 angiomotin like 1 [Homo sapiens]                          534   e-151
gi|166064029 angiomotin isoform 1 [Homo sapiens]                      446   e-125
gi|19111150 angiomotin isoform 2 [Homo sapiens]                       395   e-109
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        79   1e-14
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        79   1e-14
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         79   1e-14
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         79   1e-14
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         79   1e-14
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         79   1e-14
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         79   1e-14
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         79   1e-14
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m...    75   2e-13
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m...    75   2e-13
gi|148762940 DVL-binding protein DAPLE [Homo sapiens]                  73   9e-13
gi|16262452 cingulin [Homo sapiens]                                    73   1e-12
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    72   3e-12
gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo sapi...    70   6e-12
gi|88196790 coiled-coil domain containing 88 [Homo sapiens]            70   6e-12
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           70   1e-11
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           70   1e-11
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           70   1e-11
gi|148746195 trichohyalin [Homo sapiens]                               70   1e-11
gi|41872583 Rho-associated, coiled-coil containing protein kinas...    69   1e-11
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...    69   1e-11
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    69   2e-11
gi|203096856 kinesin family member 7 [Homo sapiens]                    68   3e-11
gi|21735548 centrosomal protein 2 [Homo sapiens]                       67   8e-11
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       67   8e-11
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    66   1e-10

>gi|32484977 angiomotin like 2 [Homo sapiens]
          Length = 780

 Score = 1520 bits (3935), Expect = 0.0
 Identities = 780/780 (100%), Positives = 780/780 (100%)

Query: 1   MRTLEDSSGTVLHRLIQEQLRYGNLTETRTLLAIQQQALRGGAGTGGTGSPQASLEILAP 60
           MRTLEDSSGTVLHRLIQEQLRYGNLTETRTLLAIQQQALRGGAGTGGTGSPQASLEILAP
Sbjct: 1   MRTLEDSSGTVLHRLIQEQLRYGNLTETRTLLAIQQQALRGGAGTGGTGSPQASLEILAP 60

Query: 61  EDSQVLQQATRQEPQGQEHQGGENHLAENTLYRLCPQPSKGEELPTYEEAKAHSQYYAAQ 120
           EDSQVLQQATRQEPQGQEHQGGENHLAENTLYRLCPQPSKGEELPTYEEAKAHSQYYAAQ
Sbjct: 61  EDSQVLQQATRQEPQGQEHQGGENHLAENTLYRLCPQPSKGEELPTYEEAKAHSQYYAAQ 120

Query: 121 QAGTRPHAGDRDPRGAPGGSRRQDEALRELRHGHVRSLSERLLQLSLERNGARAPSHMSS 180
           QAGTRPHAGDRDPRGAPGGSRRQDEALRELRHGHVRSLSERLLQLSLERNGARAPSHMSS
Sbjct: 121 QAGTRPHAGDRDPRGAPGGSRRQDEALRELRHGHVRSLSERLLQLSLERNGARAPSHMSS 180

Query: 181 SHSFPQLARNQQGPPLRGPPAEGPESRGPPPQYPHVVLAHETTTAVTDPRYRARGSPHFQ 240
           SHSFPQLARNQQGPPLRGPPAEGPESRGPPPQYPHVVLAHETTTAVTDPRYRARGSPHFQ
Sbjct: 181 SHSFPQLARNQQGPPLRGPPAEGPESRGPPPQYPHVVLAHETTTAVTDPRYRARGSPHFQ 240

Query: 241 HAEVRILQAQVPPVFLQQQQQYQYLQQSQEHPPPPHPAALGHGPLSSLSPPAVEGPVSAQ 300
           HAEVRILQAQVPPVFLQQQQQYQYLQQSQEHPPPPHPAALGHGPLSSLSPPAVEGPVSAQ
Sbjct: 241 HAEVRILQAQVPPVFLQQQQQYQYLQQSQEHPPPPHPAALGHGPLSSLSPPAVEGPVSAQ 300

Query: 301 ASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHE 360
           ASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHE
Sbjct: 301 ASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHE 360

Query: 361 SLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMV 420
           SLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMV
Sbjct: 361 SLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMV 420

Query: 421 AKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQ 480
           AKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQ
Sbjct: 421 AKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQ 480

Query: 481 AYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGS 540
           AYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGS
Sbjct: 481 AYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGS 540

Query: 541 PELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIR 600
           PELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIR
Sbjct: 541 PELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIR 600

Query: 601 HSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQG 660
           HSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQG
Sbjct: 601 HSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQG 660

Query: 661 SLRPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPARLTTADRAPTEEPVVTAPPAAHA 720
           SLRPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPARLTTADRAPTEEPVVTAPPAAHA
Sbjct: 661 SLRPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPARLTTADRAPTEEPVVTAPPAAHA 720

Query: 721 KHGSRDGSTQTEGPPDSTSTCLPPEPDSLLGCSSSQRAASLDSVATSRVQDLSDMVEILI 780
           KHGSRDGSTQTEGPPDSTSTCLPPEPDSLLGCSSSQRAASLDSVATSRVQDLSDMVEILI
Sbjct: 721 KHGSRDGSTQTEGPPDSTSTCLPPEPDSLLGCSSSQRAASLDSVATSRVQDLSDMVEILI 780


>gi|22027646 angiomotin like 1 [Homo sapiens]
          Length = 956

 Score =  534 bits (1375), Expect = e-151
 Identities = 356/810 (43%), Positives = 463/810 (57%), Gaps = 94/810 (11%)

Query: 1   MRTLEDSS-GTVLHRLIQEQLRYGNLTETRTLLAIQQQALRGGAGTGGTGSPQASLEILA 59
           MR  ED++ GTVL RLIQEQLRYG  TE   LLAIQ QA  G AG     +  +S E L 
Sbjct: 87  MRGSEDAAAGTVLQRLIQEQLRYGTPTENMNLLAIQHQAT-GSAGPAHPTNNFSSTENLT 145

Query: 60  PEDSQVLQQATRQEPQGQEHQGGENHLAENTLYRLCPQPSKGEELPTYEEAKAHSQYYAA 119
            ED Q++ Q+ RQEPQGQEHQ  +N + E  +    PQ +  EELPTYEEAKA SQ++  
Sbjct: 146 QEDPQMVYQSARQEPQGQEHQV-DNTVMEKQVRSTQPQQNN-EELPTYEEAKAQSQFFRG 203

Query: 120 QQA-----GTRPH----AGDRDPRG----------APGGSRRQDEALRELRHGHVRSLSE 160
           QQ      G   H    AG    +           A  G   +DEAL+EL+ GHVRSLSE
Sbjct: 204 QQQQQQQQGAVGHGYYMAGGTSQKSRTEGRPTVNRANSGQAHKDEALKELKQGHVRSLSE 263

Query: 161 RLLQLSLERNGARAPSHMSSSHSFPQLARNQQGPPLRGPPAEGPESRGPPPQYP------ 214
           R++QLSLERNGA+   H+  S +     +   GP    P  +  + RGPPP+YP      
Sbjct: 264 RIMQLSLERNGAK--QHLPGSGNGKGF-KVGGGPSPAQPAGKVLDPRGPPPEYPFKTKQM 320

Query: 215 ---------HVVLAHETTTAVTDPRYRARGSPHFQHAEVRILQAQVPPVF--LQQQQQYQ 263
                    H +   +    +     +   +P     +V +L+ Q PP +    +  Q  
Sbjct: 321 MSPVSKTQEHGLFYGDQHPGMLHEMVKPYPAPQPVRTDVAVLRYQPPPEYGVTSRPCQLP 380

Query: 264 YLQQSQEHPPPPHPAALGHGPLSSLSPP-------AVEGPVSAQASSATSGSAHLAQMEA 316
           +    Q+H P     +   GPL S+S P           P  A + S   G    A +E 
Sbjct: 381 FPSTMQQHSPMSSQTSSASGPLHSVSLPLPLPMALGAPQPPPAASPSQQLGPDAFAIVER 440

Query: 317 VLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTM 376
             +    L  +N  L +EL+   + A ++ K E E+QR+SEA+ESL ++++KRE+L+K M
Sbjct: 441 AQQMVEILTEENRVLHQELQGYYDNADKLHKFEKELQRISEAYESLVKSTTKRESLDKAM 500

Query: 377 RNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAK--LLAQSYEQQQEQ 434
           RNK++ E+RRL DFNRDLR+RLE+ANR+L+S+  E   G +D  A+    +Q+ E  +E+
Sbjct: 501 RNKLEGEIRRLHDFNRDLRDRLETANRQLSSREYE---GHEDKAAEGHYASQNKEFLKEK 557

Query: 435 EKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALG 494
           EKLE E+A +R A ED RR  E+L+QAL NAQ R  + EEELR+KQAYVEKVE+LQQAL 
Sbjct: 558 EKLEMELAAVRTASEDHRRHIEILDQALSNAQARVIKLEEELREKQAYVEKVEKLQQALT 617

Query: 495 QLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLRE 554
           QLQ+ACEKREQ+E RLRT LE+EL ALR QQ+      G+      PE +A  L E +RE
Sbjct: 618 QLQSACEKREQMERRLRTWLERELDALRTQQKH-----GNGQPANMPEYNAPALLELVRE 672

Query: 555 KEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSF--- 611
           KEE+ILALEADMTKWEQKYLEE  +R FAM+AAATAAA+RDTT+I HS   S   S    
Sbjct: 673 KEERILALEADMTKWEQKYLEESTIRHFAMNAAATAAAERDTTIINHSRNGSYGESSLEA 732

Query: 612 -----NEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQGSLRPAK 666
                 E ++    R Q+ME  +K LHA+I+EKDA+IKVLQQRSR+D GK    SLRPA+
Sbjct: 733 HIWQEEEEVVQANRRCQDMEYTIKNLHAKIIEKDAMIKVLQQRSRKDAGKTDSSSLRPAR 792

Query: 667 SVPSVFAAAAAGTQG-------------------WQG-----LSSSERQTADAPARLTTA 702
           SVPS+  AAA GT                     W+G     L     + A AP      
Sbjct: 793 SVPSI--AAATGTHSRQTSLTSSQLAEEKKEEKTWKGSIGLLLGKEHHEHASAPLLPPPP 850

Query: 703 DRAPTEEPVVTAPPAAHAKHGSRDGSTQTE 732
             A +     TA  +AHAK GS+D STQT+
Sbjct: 851 TSALSSIASTTAASSAHAKTGSKDSSTQTD 880


>gi|166064029 angiomotin isoform 1 [Homo sapiens]
          Length = 1084

 Score =  446 bits (1146), Expect = e-125
 Identities = 342/895 (38%), Positives = 454/895 (50%), Gaps = 184/895 (20%)

Query: 5   EDSSG--TVLHRLIQEQLRYGNLTETRTLLAIQQQALRGGAG-TGGTGSPQASLEILAPE 61
           E  SG  TVL RL+QEQLRYGN +E R+LLAI QQA   G     G+G+P    ++L+P+
Sbjct: 6   EQPSGGTTVLQRLLQEQLRYGNPSENRSLLAIHQQATGNGPPFPSGSGNPGPQSDVLSPQ 65

Query: 62  D--SQVLQQATRQEPQGQEHQGGENHLAENTLYRLCPQPSKGEELPTYEEAKAHSQYYAA 119
           D   Q++  A RQEPQGQE Q  EN + E    +L P+    EELPTYEEAK  SQY+  
Sbjct: 66  DHHQQLVAHAARQEPQGQEIQS-ENLIMEK---QLSPRMQNNEELPTYEEAKVQSQYFRG 121

Query: 120 QQAGT-------------------RPHAGDRDPRGAPGGSRRQDEALRELRHGHVRSLSE 160
           QQ  +                   RP     +P     G   QDE LR+L+ GHVRSLSE
Sbjct: 122 QQHASVGAAFYVTGVTNQKMRTEGRPSVQRLNP-----GKMHQDEGLRDLKQGHVRSLSE 176

Query: 161 RLLQLSLERNGARA-PSHMSSSHSFPQ---LARN---------QQGPPLRGPPAEGPESR 207
           RL+Q+SL  +G +A P   S+  S PQ   L +N          QGP       +G E R
Sbjct: 177 RLMQMSLATSGVKAHPPVTSAPLSPPQPNDLYKNPTSSSEFYKAQGPLPNQHSLKGMEHR 236

Query: 208 GPPPQYPHVVLAHETTTAVTDPRYRARGSPHFQH-------AEVRILQAQVPPVF-LQQQ 259
           GPPP+YP   +  ++       + +  G  + +H        E ++++ Q PP +   + 
Sbjct: 237 GPPPEYPFKGMPPQSVVC----KPQEPGHFYSEHRLNQPGRTEGQLMRYQHPPEYGAARP 292

Query: 260 QQYQYLQQSQEHPPPPHPAALGHGPLSSL----SPPAVEGPVSAQASSAT--------SG 307
            Q   L  S  +  P       H P SSL    S P ++ P S + S A           
Sbjct: 293 AQDISLPLSARNSQP-------HSPTSSLTSGGSLPLLQSPPSTRLSPARHPLVPNQGDH 345

Query: 308 SAHLAQMEAVLRENARLQRDNERL-----------------------QRELESSAEKAGR 344
           SAHL + +     N   Q D+ RL                       Q++ +   ++ G 
Sbjct: 346 SAHLPRPQQHFLPNQAHQGDHYRLSQPGLSQQQQQQQQQHHHHHHHQQQQQQQPQQQPGE 405

Query: 345 IEKLESEIQRLSEAHES--------LTRASSKREALEKTMRN----------------KM 380
                   Q  S +++         ++RA    E L    RN                K+
Sbjct: 406 AYSAMPRAQPSSASYQPVPADPFAIVSRAQQMVEILSDENRNLRQELEGCYEKVARLQKV 465

Query: 381 DSEMRRLQD--------------------------------FNRDLRERLESANRRLASK 408
           ++E++R+ +                                FNRDLRERLE+AN++LA K
Sbjct: 466 ETEIQRVSEAYENLVKSSSKREALEKAMRNKLEGEIRRMHDFNRDLRERLETANKQLAEK 525

Query: 409 TQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGR 468
             E    ++  +++L A++ E Q+E+EKLE E+A  R   EDQRR  E+ +QAL NAQ +
Sbjct: 526 EYEGSEDTRKTISQLFAKNKESQREKEKLEAELATARSTNEDQRRHIEIRDQALSNAQAK 585

Query: 469 AARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQA 528
             + EEEL+KKQ YV+KVE++QQAL QLQAACEKREQLE RLRTRLE+EL++LR QQRQ 
Sbjct: 586 VVKLEEELKKKQVYVDKVEKMQQALVQLQAACEKREQLEHRLRTRLERELESLRIQQRQ- 644

Query: 529 GAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAA 588
               G+       E +A  L E LREKEE+ILALEADMTKWEQKYLEE  MR FA+DAAA
Sbjct: 645 ----GNCQPTNVSEYNAAALMELLREKEERILALEADMTKWEQKYLEENVMRHFALDAAA 700

Query: 589 TAAAQRDTTLIRHSPQPSPSSSF-------NEGLLTGGHRHQEMESRLKVLHAQILEKDA 641
           T AAQRDTT+I HSP  S  ++         E +L    R  +ME R+K LHAQI+EKDA
Sbjct: 701 TVAAQRDTTVISHSPNTSYDTALEARIQKEEEEILMANKRCLDMEGRIKTLHAQIIEKDA 760

Query: 642 VIKVLQQRSRRDPGKAIQGS-LRPAKSVPSVFAAAAAGTQGWQGLSSS---ERQTAD--- 694
           +IKVLQQRSR++P K  Q S +RPAKS+ S+  A +        L+ S   E +  D   
Sbjct: 761 MIKVLQQRSRKEPSKTEQLSCMRPAKSLMSISNAGSGLLSHSSTLTGSPIMEEKRDDKSW 820

Query: 695 ---------APARLTTADRAPTEEPVVTAPPAAHAKHGSRDGSTQTEGPPDSTST 740
                       R       P+  P  T   +AH+K GSRD STQTE   +S  T
Sbjct: 821 KGSLGILLGGDYRAEYVPSTPSPVPPSTPLLSAHSKTGSRDCSTQTERGTESNKT 875


>gi|19111150 angiomotin isoform 2 [Homo sapiens]
          Length = 675

 Score =  395 bits (1014), Expect = e-109
 Identities = 229/440 (52%), Positives = 293/440 (66%), Gaps = 28/440 (6%)

Query: 324 LQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMDSE 383
           L  +N  L++ELE   EK  R++K+E+EIQR+SEA+E+L ++SSKREALEK MRNK++ E
Sbjct: 32  LSDENRNLRQELEGCYEKVARLQKVETEIQRVSEAYENLVKSSSKREALEKAMRNKLEGE 91

Query: 384 MRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMAL 443
           +RR+ DFNRDLRERLE+AN++LA K  E    ++  +++L A++ E Q+E+EKLE E+A 
Sbjct: 92  IRRMHDFNRDLRERLETANKQLAEKEYEGSEDTRKTISQLFAKNKESQREKEKLEAELAT 151

Query: 444 LRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKR 503
            R   EDQRR  E+ +QAL NAQ +  + EEEL+KKQ YV+KVE++QQAL QLQAACEKR
Sbjct: 152 ARSTNEDQRRHIEIRDQALSNAQAKVVKLEEELKKKQVYVDKVEKMQQALVQLQAACEKR 211

Query: 504 EQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALE 563
           EQLE RLRTRLE+EL++LR QQRQ     G+       E +A  L E LREKEE+ILALE
Sbjct: 212 EQLEHRLRTRLERELESLRIQQRQ-----GNCQPTNVSEYNAAALMELLREKEERILALE 266

Query: 564 ADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSF-------NEGLL 616
           ADMTKWEQKYLEE  MR FA+DAAAT AAQRDTT+I HSP  S  ++         E +L
Sbjct: 267 ADMTKWEQKYLEENVMRHFALDAAATVAAQRDTTVISHSPNTSYDTALEARIQKEEEEIL 326

Query: 617 TGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQGS-LRPAKSVPSVFAAA 675
               R  +ME R+K LHAQI+EKDA+IKVLQQRSR++P K  Q S +RPAKS+ S+  A 
Sbjct: 327 MANKRCLDMEGRIKTLHAQIIEKDAMIKVLQQRSRKEPSKTEQLSCMRPAKSLMSISNAG 386

Query: 676 AAGTQGWQGLSSS---ERQTAD------------APARLTTADRAPTEEPVVTAPPAAHA 720
           +        L+ S   E +  D               R       P+  P  T   +AH+
Sbjct: 387 SGLLSHSSTLTGSPIMEEKRDDKSWKGSLGILLGGDYRAEYVPSTPSPVPPSTPLLSAHS 446

Query: 721 KHGSRDGSTQTEGPPDSTST 740
           K GSRD STQTE   +S  T
Sbjct: 447 KTGSRDCSTQTERGTESNKT 466



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 67/311 (21%), Positives = 123/311 (39%), Gaps = 42/311 (13%)

Query: 452 RRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLR 511
           ++  E+L     N +       E++ + Q    +++R+ +A   L  +  KRE LE  +R
Sbjct: 26  QQMVEILSDENRNLRQELEGCYEKVARLQKVETEIQRVSEAYENLVKSSSKREALEKAMR 85

Query: 512 TRLEQELKA-------LRAQQRQAGAPGGSSGSGGSPE----LSAL----RLSEQLREKE 556
            +LE E++        LR +   A          GS +    +S L    + S++ +EK 
Sbjct: 86  NKLEGEIRRMHDFNRDLRERLETANKQLAEKEYEGSEDTRKTISQLFAKNKESQREKEKL 145

Query: 557 EQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLL 616
           E  LA      + +++++E   +R  A+  A     + +  L +            + L+
Sbjct: 146 EAELATARSTNEDQRRHIE---IRDQALSNAQAKVVKLEEELKKKQVYVDKVEKMQQALV 202

Query: 617 ---TGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQGSLRPAKSVPSVFA 673
                  + +++E RL+      LE++     +QQR         QG+ +P     S + 
Sbjct: 203 QLQAACEKREQLEHRLRTR----LERELESLRIQQR---------QGNCQPTN--VSEYN 247

Query: 674 AAAAGTQGWQGLSSSERQTADAPARLTTADRAPTEEPVVT--APPAAHAKHGSRDGSTQT 731
           AAA      + L   E +     A +T  ++   EE V+   A  AA      RD +  +
Sbjct: 248 AAAL----MELLREKEERILALEADMTKWEQKYLEENVMRHFALDAAATVAAQRDTTVIS 303

Query: 732 EGPPDSTSTCL 742
             P  S  T L
Sbjct: 304 HSPNTSYDTAL 314


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 88/309 (28%), Positives = 137/309 (44%), Gaps = 27/309 (8%)

Query: 297  VSAQASSATSGSAHLAQMEAVLRENAR-LQRDNERLQ----RELESSAEKAGRIEKLESE 351
            + A    A +G A L      +R NA    R  E+ +    R+ + +AE+  R  + E  
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989

Query: 352  IQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQE 411
            +Q+   A E   R   ++ ALE+  R K   E  R       LRER E  + R     QE
Sbjct: 1990 VQKSLAAEEEAAR--QRKAALEEVERLKAKVEEARR------LRERAEQESARQLQLAQE 2041

Query: 412  A--QAGSQDMVAKLLAQSYEQQQEQEKLEREMAL---LRGAIEDQRRRAELLEQALGNAQ 466
            A  +    +  A   A   ++Q+ Q+ L++E ++   LRG  E  RR AE  E+A   A+
Sbjct: 2042 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2101

Query: 467  GRAARAEEELRKKQAYVEKVERLQQALGQLQAACEK-REQLELRLRTRLEQELKALRAQQ 525
              AA++  ++ + +   +  E   QA  Q QAA EK R++ E     R + E  ALR +Q
Sbjct: 2102 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ 2161

Query: 526  RQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMD 585
                A               LR   Q+ E+E   L L+ + T  ++  L+E   R   + 
Sbjct: 2162 ----AADAEMEKHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQR---LK 2213

Query: 586  AAATAAAQR 594
            A AT AA++
Sbjct: 2214 AEATEAARQ 2222



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 69/307 (22%), Positives = 141/307 (45%), Gaps = 19/307 (6%)

Query: 298  SAQASSATSGSAHLAQMEAVLRENA--RLQRDNERLQRELESSAE------KAGRIEKLE 349
            + Q ++     A L Q +  L +    RLQ D E++ ++L    +      +A R  +LE
Sbjct: 2318 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2377

Query: 350  --SEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLAS 407
              +E +RL      ++RA ++ E   +  R + +    +L       R  L +  +    
Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH------RTELATQEKVTLV 2431

Query: 408  KTQEAQAGSQDMVAKLLAQSY-EQQQEQEKLEREMALLRGAIEDQR--RRAELLEQALGN 464
            +T E Q    D  A+ L ++  E ++E+EKL++E  LL+   E+ +  ++ +LL++    
Sbjct: 2432 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2491

Query: 465  AQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQ 524
             Q   +  +  L++++   ++  +L+Q      A  ++  + + R + ++EQE + L A 
Sbjct: 2492 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2551

Query: 525  QRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAM 584
              +A      +  G   +   L+  EQ R ++E++LA E    + + + LEE+     A 
Sbjct: 2552 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2611

Query: 585  DAAATAA 591
                TA+
Sbjct: 2612 SEEVTAS 2618



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 83/331 (25%), Positives = 147/331 (44%), Gaps = 31/331 (9%)

Query: 293  VEGPVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEI 352
            VE  +  Q   A + +   AQ E   +E    QR  E + R  E++ +   +   ++ E+
Sbjct: 1365 VEAALEKQRQLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVDAQQQKRSIQEEL 1422

Query: 353  QRLSEAHESLTRASSKREALEKTMRNKMDSEMR--RLQ-DFNRDLRERLESANRRLASKT 409
            Q+L ++ E+  +A +++    +  R +++ E+R  RLQ +     R   E   + L ++ 
Sbjct: 1423 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1482

Query: 410  QEAQA---GSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQ 466
            +EA+A    +Q+   +L  Q  ++ Q + + E E+A    A  +  R  +   QAL   +
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1542

Query: 467  GRAARAEEELRKKQAYVEKVERLQQALGQLQAA------------CEKREQLELRLR--- 511
             +A  AE  LR  QA VE+  ++Q AL   Q +             EK  QLE  L+   
Sbjct: 1543 LQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1600

Query: 512  ---TRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREK-EEQILALEADMT 567
                +L +E  A R  Q+QA A      +    E   L+ +E LR + + + +A +  + 
Sbjct: 1601 VAVAQLREE--AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658

Query: 568  KWEQKYLEERAMRQFAMDAAATAAAQRDTTL 598
            + E +  +E A R+      A   A R   L
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQREL 1689



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 79/379 (20%), Positives = 158/379 (41%), Gaps = 31/379 (8%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREA 371
            A+ E    +  + Q + ERL+R+++  +++     K ++E++  S        A  K+ A
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASRVKAEAEAAREKQRA 1534

Query: 372  LE--KTMRNKMDSEMRRLQDFN----RDLRERLESANRRLASKTQEAQAGSQDMVAKLLA 425
            L+  + +R + +   RRL+       R ++  LE+A R   ++ Q  +A   +  A+L  
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1594

Query: 426  QSYEQ-------QQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRK 478
               E+       ++E E+  ++ A    A E+  R  E  +     A     +AEE  ++
Sbjct: 1595 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1654

Query: 479  KQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSG 538
            K     + E+ ++   +      K E+  +R R   EQEL+    +QRQ     G++   
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE----KQRQLAE--GTAQQR 1708

Query: 539  GSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTL 598
             + E   +RL  +  + E+Q   LE ++ + +++       RQ      A   A+ +  L
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768

Query: 599  IRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAI 658
               +     S S +E       R +    R +    ++ E+ A ++ L + ++R    A 
Sbjct: 1769 ASKARAEEESRSTSE---KSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAE 1821

Query: 659  QGSLRPAKSVPSVFAAAAA 677
            + + R       V A   A
Sbjct: 1822 EDAARQRAEAERVLAEKLA 1840



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 98/399 (24%), Positives = 175/399 (43%), Gaps = 51/399 (12%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKRE 370
            LA+  A + E  RL+ + E   +E E+  E+  R+ + E+  +R  E   +  +A  +  
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894

Query: 371  ALEKTMRNKMDSEMRRLQDFNRD-LRERLESANRRLASKT--QEAQAGSQDM---VAKLL 424
              +  +R   DSE+ R +    D LR+R +     LA K   ++A AG  ++   + ++ 
Sbjct: 1895 LAQ--LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1952

Query: 425  AQSYEQQQEQEKLEREMALLRG-AIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYV 483
            + + +  + +E+ E E A  R  A E++RRR E  E+     Q   A  EE  R+++A +
Sbjct: 1953 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV----QKSLAAEEEAARQRKAAL 2008

Query: 484  EKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPEL 543
            E+VERL+  + + +           RLR R EQE     A+Q Q              + 
Sbjct: 2009 EEVERLKAKVEEAR-----------RLRERAEQE----SARQLQLAQEAAQKRLQAEEKA 2053

Query: 544  SALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDA-AATAAAQRDTTLIRHS 602
             A  + ++ +E ++    L+ + +  +Q   E  A R+ A +A  A   A+R+    R  
Sbjct: 2054 HAFAVQQKEQELQQ---TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110

Query: 603  PQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQGSL 662
             + +      E L        +  ++ +   A+ L K+A     Q+ +RR   +A Q +L
Sbjct: 2111 VEEA------ERLKQSAEEQAQARAQAQAA-AEKLRKEAE----QEAARR--AQAEQAAL 2157

Query: 663  RPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPARLTT 701
            R  +      AA A   +  +    + RQ A     LTT
Sbjct: 2158 RQKQ------AADAEMEKHKKFAEQTLRQKAQVEQELTT 2190



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 84/351 (23%), Positives = 157/351 (44%), Gaps = 75/351 (21%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSK-- 368
            L + +AVL +    QR+ E+L R+L    E A  +     + +R  E  +++  A S+  
Sbjct: 1185 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1244

Query: 369  REAL--EKTMRNKMDSEMRRLQDFNR----------DLRERLESANRRLA-----SKTQE 411
            RE L  E+ +  +++    ++++  R          D   +L +   +L      +K  +
Sbjct: 1245 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1304

Query: 412  AQAGSQDMVA--------------------KLLAQSYEQQQEQEKL-------ERE-MAL 443
             Q+GS+ ++                     K ++++  + +E+E+L       ERE +A 
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1364

Query: 444  LRGAIEDQRRRAELLEQALGNAQGRAAR-----AEEELRKKQAYVEKVER---LQQALGQ 495
            +  A+E QR+ AE   QA   A+  A        EE +R+++A V+  ++   +Q+ L Q
Sbjct: 1365 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1424

Query: 496  LQAACE-----KREQLEL--RLRTRLEQELKALRAQ----QRQAGAPGGSSGSGGSPELS 544
            L+ + E     K  Q E   R R R+E+E++ +R Q    +RQ G        G   EL 
Sbjct: 1425 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG--------GAEGELQ 1476

Query: 545  ALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRD 595
            ALR   +  E +++    EA+  +  Q   E +  RQ  ++ A+   A+ +
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLR-RQVQDESQRKRQAEVELASRVKAEAE 1526



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 74/331 (22%), Positives = 141/331 (42%), Gaps = 42/331 (12%)

Query: 313  QMEAVLRENARLQ--------RDNERLQRELESSAEK-------AGRIEKLESEIQRLSE 357
            QME + +  AR++        RD +  QR L+  AEK       A R+     E  RL +
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2295

Query: 358  -AHESLTR--------ASSKREALEKTMRNKMDSEMRRLQ-DFNRDLRERLESANRRLAS 407
             A E L +           K +A+++  R K ++E+ + Q +  ++   RL+    ++A 
Sbjct: 2296 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2355

Query: 408  KTQEAQAGSQDMVAKLLAQSYEQQQEQEKLE---REMALLRGAIEDQRRRAELLEQALGN 464
            +  E   G Q  +     +  E   E E+L+    EM+  +   E+  +R     + +G 
Sbjct: 2356 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2415

Query: 465  AQGRAARAEEEL--------RKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQ 516
               R   A +E          ++Q      ERL++A+ +L+   EK +Q E +L     +
Sbjct: 2416 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLKSE 2474

Query: 517  ELKALRAQQ--RQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQ-KY 573
            E++ ++ +Q  ++  A   S  S     L   R  EQ + K EQ+   + ++ K +Q + 
Sbjct: 2475 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL--FQDEVAKAQQLRE 2532

Query: 574  LEERAMRQFAMDAAATAAAQRDTTLIRHSPQ 604
             ++R  +Q   +     A+  +    +H  +
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 80/317 (25%), Positives = 135/317 (42%), Gaps = 43/317 (13%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEK-LESEIQRLSEAHESLTRASSKRE 370
            A+   V  E A+   + E LQ +  S AEK  ++E+ L+ E   +++  E   R + ++ 
Sbjct: 1560 ARQVQVALETAQRSAEAE-LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1618

Query: 371  ALEKTMRNKMDSEMRRLQ-DFNRDLRERLESAN----RRLASKTQEAQAGSQDMVAKLLA 425
              E+  R + + E+ R Q   N  LR RL++      + LA    E Q    +  A+   
Sbjct: 1619 EAERA-REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1677

Query: 426  QSYEQ--------QQEQEK--------------LEREMALLRGAIEDQRRRAELLEQALG 463
            ++ EQ        +QE EK               E+E+  LR   E   ++ +LLE+ L 
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737

Query: 464  NAQGRAARAEEELRKKQAYVEKVE-RLQQALGQLQAACEKREQLELRLRTRLEQELKALR 522
              Q  AA A ++ ++ +A + KV   ++  L     A E+      + + RLE E    R
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797

Query: 523  -----AQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILAL-EADMTKWE------ 570
                 A + +A A         + E +A + +E  R   E++ A+ EA   K E      
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857

Query: 571  QKYLEERAMRQFAMDAA 587
            +K  E   +R+ A D A
Sbjct: 1858 EKEAENERLRRLAEDEA 1874



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 38/171 (22%), Positives = 80/171 (46%), Gaps = 2/171 (1%)

Query: 322  ARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMD 381
            A L+R+ E+LQ+E +    K+  ++ ++ E Q L E         S++++L +  R  ++
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQQSFLSEKDSLLQRERF-IE 2510

Query: 382  SEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREM 441
             E  +L+   +D   + +        + Q+ +   Q +VA +      Q + +E + R+ 
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570

Query: 442  ALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQA 492
              L+   + +R++ ELL +     + +    EE+ R   A+ E+V   Q A
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621



 Score = 36.6 bits (83), Expect = 0.092
 Identities = 68/276 (24%), Positives = 111/276 (40%), Gaps = 48/276 (17%)

Query: 319  RENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTM-- 376
            RE A+   + ++ Q E+E   +   R   L +E +++    E    A + R  LE T+  
Sbjct: 1017 RECAQRIAEQQKAQAEVEGLGKGVAR---LSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073

Query: 377  ----RNKMDSEMRRLQDFNRDLR--ERLESANRRLASKTQEAQA---------GSQDMVA 421
                R+     + +L+  +  +R  +  E   R    + +EAQA          ++  + 
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1133

Query: 422  KLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQA 481
            KL AQ+  QQ   + L  E   LRGA E   R    L+Q  G       R  E  R ++ 
Sbjct: 1134 KLRAQAEAQQPTFDALRDE---LRGAQEVGER----LQQRHGE------RDVEVERWRER 1180

Query: 482  YVEKVERLQQALGQLQAACEKREQLELRLRTRLEQE------LKALRAQQRQAGAPGGSS 535
              + +ER Q  L Q      + EQL  +LR   E        L+  R +Q Q  A     
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA----- 1235

Query: 536  GSGGSPELSALRLSEQLREKEEQILALEADMTKWEQ 571
                 P   +  + EQLR+++  +  +E    K E+
Sbjct: 1236 ----MPLADSQAVREQLRQEQALLEEIERHGEKVEE 1267


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 88/309 (28%), Positives = 137/309 (44%), Gaps = 27/309 (8%)

Query: 297  VSAQASSATSGSAHLAQMEAVLRENAR-LQRDNERLQ----RELESSAEKAGRIEKLESE 351
            + A    A +G A L      +R NA    R  E+ +    R+ + +AE+  R  + E  
Sbjct: 1934 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1993

Query: 352  IQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQE 411
            +Q+   A E   R   ++ ALE+  R K   E  R       LRER E  + R     QE
Sbjct: 1994 VQKSLAAEEEAAR--QRKAALEEVERLKAKVEEARR------LRERAEQESARQLQLAQE 2045

Query: 412  A--QAGSQDMVAKLLAQSYEQQQEQEKLEREMAL---LRGAIEDQRRRAELLEQALGNAQ 466
            A  +    +  A   A   ++Q+ Q+ L++E ++   LRG  E  RR AE  E+A   A+
Sbjct: 2046 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2105

Query: 467  GRAARAEEELRKKQAYVEKVERLQQALGQLQAACEK-REQLELRLRTRLEQELKALRAQQ 525
              AA++  ++ + +   +  E   QA  Q QAA EK R++ E     R + E  ALR +Q
Sbjct: 2106 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ 2165

Query: 526  RQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMD 585
                A               LR   Q+ E+E   L L+ + T  ++  L+E   R   + 
Sbjct: 2166 ----AADAEMEKHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQR---LK 2217

Query: 586  AAATAAAQR 594
            A AT AA++
Sbjct: 2218 AEATEAARQ 2226



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 69/307 (22%), Positives = 141/307 (45%), Gaps = 19/307 (6%)

Query: 298  SAQASSATSGSAHLAQMEAVLRENA--RLQRDNERLQRELESSAE------KAGRIEKLE 349
            + Q ++     A L Q +  L +    RLQ D E++ ++L    +      +A R  +LE
Sbjct: 2322 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2381

Query: 350  --SEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLAS 407
              +E +RL      ++RA ++ E   +  R + +    +L       R  L +  +    
Sbjct: 2382 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH------RTELATQEKVTLV 2435

Query: 408  KTQEAQAGSQDMVAKLLAQSY-EQQQEQEKLEREMALLRGAIEDQR--RRAELLEQALGN 464
            +T E Q    D  A+ L ++  E ++E+EKL++E  LL+   E+ +  ++ +LL++    
Sbjct: 2436 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2495

Query: 465  AQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQ 524
             Q   +  +  L++++   ++  +L+Q      A  ++  + + R + ++EQE + L A 
Sbjct: 2496 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2555

Query: 525  QRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAM 584
              +A      +  G   +   L+  EQ R ++E++LA E    + + + LEE+     A 
Sbjct: 2556 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2615

Query: 585  DAAATAA 591
                TA+
Sbjct: 2616 SEEVTAS 2622



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 83/331 (25%), Positives = 147/331 (44%), Gaps = 31/331 (9%)

Query: 293  VEGPVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEI 352
            VE  +  Q   A + +   AQ E   +E    QR  E + R  E++ +   +   ++ E+
Sbjct: 1369 VEAALEKQRQLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVDAQQQKRSIQEEL 1426

Query: 353  QRLSEAHESLTRASSKREALEKTMRNKMDSEMR--RLQ-DFNRDLRERLESANRRLASKT 409
            Q+L ++ E+  +A +++    +  R +++ E+R  RLQ +     R   E   + L ++ 
Sbjct: 1427 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1486

Query: 410  QEAQA---GSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQ 466
            +EA+A    +Q+   +L  Q  ++ Q + + E E+A    A  +  R  +   QAL   +
Sbjct: 1487 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1546

Query: 467  GRAARAEEELRKKQAYVEKVERLQQALGQLQAA------------CEKREQLELRLR--- 511
             +A  AE  LR  QA VE+  ++Q AL   Q +             EK  QLE  L+   
Sbjct: 1547 LQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1604

Query: 512  ---TRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREK-EEQILALEADMT 567
                +L +E  A R  Q+QA A      +    E   L+ +E LR + + + +A +  + 
Sbjct: 1605 VAVAQLREE--AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1662

Query: 568  KWEQKYLEERAMRQFAMDAAATAAAQRDTTL 598
            + E +  +E A R+      A   A R   L
Sbjct: 1663 QAEAEKQKEEAEREARRRGKAEEQAVRQREL 1693



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 79/379 (20%), Positives = 158/379 (41%), Gaps = 31/379 (8%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREA 371
            A+ E    +  + Q + ERL+R+++  +++     K ++E++  S        A  K+ A
Sbjct: 1484 ARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASRVKAEAEAAREKQRA 1538

Query: 372  LE--KTMRNKMDSEMRRLQDFN----RDLRERLESANRRLASKTQEAQAGSQDMVAKLLA 425
            L+  + +R + +   RRL+       R ++  LE+A R   ++ Q  +A   +  A+L  
Sbjct: 1539 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1598

Query: 426  QSYEQ-------QQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRK 478
               E+       ++E E+  ++ A    A E+  R  E  +     A     +AEE  ++
Sbjct: 1599 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1658

Query: 479  KQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSG 538
            K     + E+ ++   +      K E+  +R R   EQEL+    +QRQ     G++   
Sbjct: 1659 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE----KQRQLAE--GTAQQR 1712

Query: 539  GSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTL 598
             + E   +RL  +  + E+Q   LE ++ + +++       RQ      A   A+ +  L
Sbjct: 1713 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1772

Query: 599  IRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAI 658
               +     S S +E       R +    R +    ++ E+ A ++ L + ++R    A 
Sbjct: 1773 ASKARAEEESRSTSE---KSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAE 1825

Query: 659  QGSLRPAKSVPSVFAAAAA 677
            + + R       V A   A
Sbjct: 1826 EDAARQRAEAERVLAEKLA 1844



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 98/399 (24%), Positives = 175/399 (43%), Gaps = 51/399 (12%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKRE 370
            LA+  A + E  RL+ + E   +E E+  E+  R+ + E+  +R  E   +  +A  +  
Sbjct: 1839 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1898

Query: 371  ALEKTMRNKMDSEMRRLQDFNRD-LRERLESANRRLASKT--QEAQAGSQDM---VAKLL 424
              +  +R   DSE+ R +    D LR+R +     LA K   ++A AG  ++   + ++ 
Sbjct: 1899 LAQ--LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1956

Query: 425  AQSYEQQQEQEKLEREMALLRG-AIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYV 483
            + + +  + +E+ E E A  R  A E++RRR E  E+     Q   A  EE  R+++A +
Sbjct: 1957 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV----QKSLAAEEEAARQRKAAL 2012

Query: 484  EKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPEL 543
            E+VERL+  + + +           RLR R EQE     A+Q Q              + 
Sbjct: 2013 EEVERLKAKVEEAR-----------RLRERAEQE----SARQLQLAQEAAQKRLQAEEKA 2057

Query: 544  SALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDA-AATAAAQRDTTLIRHS 602
             A  + ++ +E ++    L+ + +  +Q   E  A R+ A +A  A   A+R+    R  
Sbjct: 2058 HAFAVQQKEQELQQ---TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2114

Query: 603  PQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQGSL 662
             + +      E L        +  ++ +   A+ L K+A     Q+ +RR   +A Q +L
Sbjct: 2115 VEEA------ERLKQSAEEQAQARAQAQAA-AEKLRKEAE----QEAARR--AQAEQAAL 2161

Query: 663  RPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPARLTT 701
            R  +      AA A   +  +    + RQ A     LTT
Sbjct: 2162 RQKQ------AADAEMEKHKKFAEQTLRQKAQVEQELTT 2194



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 84/351 (23%), Positives = 157/351 (44%), Gaps = 75/351 (21%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSK-- 368
            L + +AVL +    QR+ E+L R+L    E A  +     + +R  E  +++  A S+  
Sbjct: 1189 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1248

Query: 369  REAL--EKTMRNKMDSEMRRLQDFNR----------DLRERLESANRRLA-----SKTQE 411
            RE L  E+ +  +++    ++++  R          D   +L +   +L      +K  +
Sbjct: 1249 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1308

Query: 412  AQAGSQDMVA--------------------KLLAQSYEQQQEQEKL-------ERE-MAL 443
             Q+GS+ ++                     K ++++  + +E+E+L       ERE +A 
Sbjct: 1309 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1368

Query: 444  LRGAIEDQRRRAELLEQALGNAQGRAAR-----AEEELRKKQAYVEKVER---LQQALGQ 495
            +  A+E QR+ AE   QA   A+  A        EE +R+++A V+  ++   +Q+ L Q
Sbjct: 1369 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1428

Query: 496  LQAACE-----KREQLEL--RLRTRLEQELKALRAQ----QRQAGAPGGSSGSGGSPELS 544
            L+ + E     K  Q E   R R R+E+E++ +R Q    +RQ G        G   EL 
Sbjct: 1429 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG--------GAEGELQ 1480

Query: 545  ALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRD 595
            ALR   +  E +++    EA+  +  Q   E +  RQ  ++ A+   A+ +
Sbjct: 1481 ALRARAEEAEAQKRQAQEEAERLR-RQVQDESQRKRQAEVELASRVKAEAE 1530



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 74/331 (22%), Positives = 141/331 (42%), Gaps = 42/331 (12%)

Query: 313  QMEAVLRENARLQ--------RDNERLQRELESSAEK-------AGRIEKLESEIQRLSE 357
            QME + +  AR++        RD +  QR L+  AEK       A R+     E  RL +
Sbjct: 2240 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2299

Query: 358  -AHESLTR--------ASSKREALEKTMRNKMDSEMRRLQ-DFNRDLRERLESANRRLAS 407
             A E L +           K +A+++  R K ++E+ + Q +  ++   RL+    ++A 
Sbjct: 2300 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2359

Query: 408  KTQEAQAGSQDMVAKLLAQSYEQQQEQEKLE---REMALLRGAIEDQRRRAELLEQALGN 464
            +  E   G Q  +     +  E   E E+L+    EM+  +   E+  +R     + +G 
Sbjct: 2360 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2419

Query: 465  AQGRAARAEEEL--------RKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQ 516
               R   A +E          ++Q      ERL++A+ +L+   EK +Q E +L     +
Sbjct: 2420 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLKSE 2478

Query: 517  ELKALRAQQ--RQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQ-KY 573
            E++ ++ +Q  ++  A   S  S     L   R  EQ + K EQ+   + ++ K +Q + 
Sbjct: 2479 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL--FQDEVAKAQQLRE 2536

Query: 574  LEERAMRQFAMDAAATAAAQRDTTLIRHSPQ 604
             ++R  +Q   +     A+  +    +H  +
Sbjct: 2537 EQQRQQQQMEQERQRLVASMEEARRRQHEAE 2567



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 80/317 (25%), Positives = 135/317 (42%), Gaps = 43/317 (13%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEK-LESEIQRLSEAHESLTRASSKRE 370
            A+   V  E A+   + E LQ +  S AEK  ++E+ L+ E   +++  E   R + ++ 
Sbjct: 1564 ARQVQVALETAQRSAEAE-LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1622

Query: 371  ALEKTMRNKMDSEMRRLQ-DFNRDLRERLESAN----RRLASKTQEAQAGSQDMVAKLLA 425
              E+  R + + E+ R Q   N  LR RL++      + LA    E Q    +  A+   
Sbjct: 1623 EAERA-REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1681

Query: 426  QSYEQ--------QQEQEK--------------LEREMALLRGAIEDQRRRAELLEQALG 463
            ++ EQ        +QE EK               E+E+  LR   E   ++ +LLE+ L 
Sbjct: 1682 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1741

Query: 464  NAQGRAARAEEELRKKQAYVEKVE-RLQQALGQLQAACEKREQLELRLRTRLEQELKALR 522
              Q  AA A ++ ++ +A + KV   ++  L     A E+      + + RLE E    R
Sbjct: 1742 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1801

Query: 523  -----AQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILAL-EADMTKWE------ 570
                 A + +A A         + E +A + +E  R   E++ A+ EA   K E      
Sbjct: 1802 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1861

Query: 571  QKYLEERAMRQFAMDAA 587
            +K  E   +R+ A D A
Sbjct: 1862 EKEAENERLRRLAEDEA 1878



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 38/171 (22%), Positives = 80/171 (46%), Gaps = 2/171 (1%)

Query: 322  ARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMD 381
            A L+R+ E+LQ+E +    K+  ++ ++ E Q L E         S++++L +  R  ++
Sbjct: 2457 AELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQQSFLSEKDSLLQRERF-IE 2514

Query: 382  SEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREM 441
             E  +L+   +D   + +        + Q+ +   Q +VA +      Q + +E + R+ 
Sbjct: 2515 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2574

Query: 442  ALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQA 492
              L+   + +R++ ELL +     + +    EE+ R   A+ E+V   Q A
Sbjct: 2575 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2625



 Score = 36.6 bits (83), Expect = 0.092
 Identities = 68/276 (24%), Positives = 111/276 (40%), Gaps = 48/276 (17%)

Query: 319  RENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTM-- 376
            RE A+   + ++ Q E+E   +   R   L +E +++    E    A + R  LE T+  
Sbjct: 1021 RECAQRIAEQQKAQAEVEGLGKGVAR---LSAEAEKVLALPEPSPAAPTLRSELELTLGK 1077

Query: 377  ----RNKMDSEMRRLQDFNRDLR--ERLESANRRLASKTQEAQA---------GSQDMVA 421
                R+     + +L+  +  +R  +  E   R    + +EAQA          ++  + 
Sbjct: 1078 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1137

Query: 422  KLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQA 481
            KL AQ+  QQ   + L  E   LRGA E   R    L+Q  G       R  E  R ++ 
Sbjct: 1138 KLRAQAEAQQPTFDALRDE---LRGAQEVGER----LQQRHGE------RDVEVERWRER 1184

Query: 482  YVEKVERLQQALGQLQAACEKREQLELRLRTRLEQE------LKALRAQQRQAGAPGGSS 535
              + +ER Q  L Q      + EQL  +LR   E        L+  R +Q Q  A     
Sbjct: 1185 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA----- 1239

Query: 536  GSGGSPELSALRLSEQLREKEEQILALEADMTKWEQ 571
                 P   +  + EQLR+++  +  +E    K E+
Sbjct: 1240 ----MPLADSQAVREQLRQEQALLEEIERHGEKVEE 1271


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 88/309 (28%), Positives = 137/309 (44%), Gaps = 27/309 (8%)

Query: 297  VSAQASSATSGSAHLAQMEAVLRENAR-LQRDNERLQ----RELESSAEKAGRIEKLESE 351
            + A    A +G A L      +R NA    R  E+ +    R+ + +AE+  R  + E  
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989

Query: 352  IQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQE 411
            +Q+   A E   R   ++ ALE+  R K   E  R       LRER E  + R     QE
Sbjct: 1990 VQKSLAAEEEAAR--QRKAALEEVERLKAKVEEARR------LRERAEQESARQLQLAQE 2041

Query: 412  A--QAGSQDMVAKLLAQSYEQQQEQEKLEREMAL---LRGAIEDQRRRAELLEQALGNAQ 466
            A  +    +  A   A   ++Q+ Q+ L++E ++   LRG  E  RR AE  E+A   A+
Sbjct: 2042 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2101

Query: 467  GRAARAEEELRKKQAYVEKVERLQQALGQLQAACEK-REQLELRLRTRLEQELKALRAQQ 525
              AA++  ++ + +   +  E   QA  Q QAA EK R++ E     R + E  ALR +Q
Sbjct: 2102 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ 2161

Query: 526  RQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMD 585
                A               LR   Q+ E+E   L L+ + T  ++  L+E   R   + 
Sbjct: 2162 ----AADAEMEKHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQR---LK 2213

Query: 586  AAATAAAQR 594
            A AT AA++
Sbjct: 2214 AEATEAARQ 2222



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 69/307 (22%), Positives = 141/307 (45%), Gaps = 19/307 (6%)

Query: 298  SAQASSATSGSAHLAQMEAVLRENA--RLQRDNERLQRELESSAE------KAGRIEKLE 349
            + Q ++     A L Q +  L +    RLQ D E++ ++L    +      +A R  +LE
Sbjct: 2318 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2377

Query: 350  --SEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLAS 407
              +E +RL      ++RA ++ E   +  R + +    +L       R  L +  +    
Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH------RTELATQEKVTLV 2431

Query: 408  KTQEAQAGSQDMVAKLLAQSY-EQQQEQEKLEREMALLRGAIEDQR--RRAELLEQALGN 464
            +T E Q    D  A+ L ++  E ++E+EKL++E  LL+   E+ +  ++ +LL++    
Sbjct: 2432 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2491

Query: 465  AQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQ 524
             Q   +  +  L++++   ++  +L+Q      A  ++  + + R + ++EQE + L A 
Sbjct: 2492 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2551

Query: 525  QRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAM 584
              +A      +  G   +   L+  EQ R ++E++LA E    + + + LEE+     A 
Sbjct: 2552 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2611

Query: 585  DAAATAA 591
                TA+
Sbjct: 2612 SEEVTAS 2618



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 83/331 (25%), Positives = 147/331 (44%), Gaps = 31/331 (9%)

Query: 293  VEGPVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEI 352
            VE  +  Q   A + +   AQ E   +E    QR  E + R  E++ +   +   ++ E+
Sbjct: 1365 VEAALEKQRQLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVDAQQQKRSIQEEL 1422

Query: 353  QRLSEAHESLTRASSKREALEKTMRNKMDSEMR--RLQ-DFNRDLRERLESANRRLASKT 409
            Q+L ++ E+  +A +++    +  R +++ E+R  RLQ +     R   E   + L ++ 
Sbjct: 1423 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1482

Query: 410  QEAQA---GSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQ 466
            +EA+A    +Q+   +L  Q  ++ Q + + E E+A    A  +  R  +   QAL   +
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1542

Query: 467  GRAARAEEELRKKQAYVEKVERLQQALGQLQAA------------CEKREQLELRLR--- 511
             +A  AE  LR  QA VE+  ++Q AL   Q +             EK  QLE  L+   
Sbjct: 1543 LQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1600

Query: 512  ---TRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREK-EEQILALEADMT 567
                +L +E  A R  Q+QA A      +    E   L+ +E LR + + + +A +  + 
Sbjct: 1601 VAVAQLREE--AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658

Query: 568  KWEQKYLEERAMRQFAMDAAATAAAQRDTTL 598
            + E +  +E A R+      A   A R   L
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQREL 1689



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 79/379 (20%), Positives = 158/379 (41%), Gaps = 31/379 (8%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREA 371
            A+ E    +  + Q + ERL+R+++  +++     K ++E++  S        A  K+ A
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASRVKAEAEAAREKQRA 1534

Query: 372  LE--KTMRNKMDSEMRRLQDFN----RDLRERLESANRRLASKTQEAQAGSQDMVAKLLA 425
            L+  + +R + +   RRL+       R ++  LE+A R   ++ Q  +A   +  A+L  
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1594

Query: 426  QSYEQ-------QQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRK 478
               E+       ++E E+  ++ A    A E+  R  E  +     A     +AEE  ++
Sbjct: 1595 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1654

Query: 479  KQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSG 538
            K     + E+ ++   +      K E+  +R R   EQEL+    +QRQ     G++   
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE----KQRQLAE--GTAQQR 1708

Query: 539  GSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTL 598
             + E   +RL  +  + E+Q   LE ++ + +++       RQ      A   A+ +  L
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768

Query: 599  IRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAI 658
               +     S S +E       R +    R +    ++ E+ A ++ L + ++R    A 
Sbjct: 1769 ASKARAEEESRSTSE---KSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAE 1821

Query: 659  QGSLRPAKSVPSVFAAAAA 677
            + + R       V A   A
Sbjct: 1822 EDAARQRAEAERVLAEKLA 1840



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 98/399 (24%), Positives = 175/399 (43%), Gaps = 51/399 (12%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKRE 370
            LA+  A + E  RL+ + E   +E E+  E+  R+ + E+  +R  E   +  +A  +  
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894

Query: 371  ALEKTMRNKMDSEMRRLQDFNRD-LRERLESANRRLASKT--QEAQAGSQDM---VAKLL 424
              +  +R   DSE+ R +    D LR+R +     LA K   ++A AG  ++   + ++ 
Sbjct: 1895 LAQ--LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1952

Query: 425  AQSYEQQQEQEKLEREMALLRG-AIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYV 483
            + + +  + +E+ E E A  R  A E++RRR E  E+     Q   A  EE  R+++A +
Sbjct: 1953 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV----QKSLAAEEEAARQRKAAL 2008

Query: 484  EKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPEL 543
            E+VERL+  + + +           RLR R EQE     A+Q Q              + 
Sbjct: 2009 EEVERLKAKVEEAR-----------RLRERAEQE----SARQLQLAQEAAQKRLQAEEKA 2053

Query: 544  SALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDA-AATAAAQRDTTLIRHS 602
             A  + ++ +E ++    L+ + +  +Q   E  A R+ A +A  A   A+R+    R  
Sbjct: 2054 HAFAVQQKEQELQQ---TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110

Query: 603  PQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQGSL 662
             + +      E L        +  ++ +   A+ L K+A     Q+ +RR   +A Q +L
Sbjct: 2111 VEEA------ERLKQSAEEQAQARAQAQAA-AEKLRKEAE----QEAARR--AQAEQAAL 2157

Query: 663  RPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPARLTT 701
            R  +      AA A   +  +    + RQ A     LTT
Sbjct: 2158 RQKQ------AADAEMEKHKKFAEQTLRQKAQVEQELTT 2190



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 84/351 (23%), Positives = 157/351 (44%), Gaps = 75/351 (21%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSK-- 368
            L + +AVL +    QR+ E+L R+L    E A  +     + +R  E  +++  A S+  
Sbjct: 1185 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1244

Query: 369  REAL--EKTMRNKMDSEMRRLQDFNR----------DLRERLESANRRLA-----SKTQE 411
            RE L  E+ +  +++    ++++  R          D   +L +   +L      +K  +
Sbjct: 1245 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1304

Query: 412  AQAGSQDMVA--------------------KLLAQSYEQQQEQEKL-------ERE-MAL 443
             Q+GS+ ++                     K ++++  + +E+E+L       ERE +A 
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1364

Query: 444  LRGAIEDQRRRAELLEQALGNAQGRAAR-----AEEELRKKQAYVEKVER---LQQALGQ 495
            +  A+E QR+ AE   QA   A+  A        EE +R+++A V+  ++   +Q+ L Q
Sbjct: 1365 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1424

Query: 496  LQAACE-----KREQLEL--RLRTRLEQELKALRAQ----QRQAGAPGGSSGSGGSPELS 544
            L+ + E     K  Q E   R R R+E+E++ +R Q    +RQ G        G   EL 
Sbjct: 1425 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG--------GAEGELQ 1476

Query: 545  ALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRD 595
            ALR   +  E +++    EA+  +  Q   E +  RQ  ++ A+   A+ +
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLR-RQVQDESQRKRQAEVELASRVKAEAE 1526



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 74/331 (22%), Positives = 141/331 (42%), Gaps = 42/331 (12%)

Query: 313  QMEAVLRENARLQ--------RDNERLQRELESSAEK-------AGRIEKLESEIQRLSE 357
            QME + +  AR++        RD +  QR L+  AEK       A R+     E  RL +
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2295

Query: 358  -AHESLTR--------ASSKREALEKTMRNKMDSEMRRLQ-DFNRDLRERLESANRRLAS 407
             A E L +           K +A+++  R K ++E+ + Q +  ++   RL+    ++A 
Sbjct: 2296 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2355

Query: 408  KTQEAQAGSQDMVAKLLAQSYEQQQEQEKLE---REMALLRGAIEDQRRRAELLEQALGN 464
            +  E   G Q  +     +  E   E E+L+    EM+  +   E+  +R     + +G 
Sbjct: 2356 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2415

Query: 465  AQGRAARAEEEL--------RKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQ 516
               R   A +E          ++Q      ERL++A+ +L+   EK +Q E +L     +
Sbjct: 2416 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLKSE 2474

Query: 517  ELKALRAQQ--RQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQ-KY 573
            E++ ++ +Q  ++  A   S  S     L   R  EQ + K EQ+   + ++ K +Q + 
Sbjct: 2475 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL--FQDEVAKAQQLRE 2532

Query: 574  LEERAMRQFAMDAAATAAAQRDTTLIRHSPQ 604
             ++R  +Q   +     A+  +    +H  +
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 80/317 (25%), Positives = 135/317 (42%), Gaps = 43/317 (13%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEK-LESEIQRLSEAHESLTRASSKRE 370
            A+   V  E A+   + E LQ +  S AEK  ++E+ L+ E   +++  E   R + ++ 
Sbjct: 1560 ARQVQVALETAQRSAEAE-LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1618

Query: 371  ALEKTMRNKMDSEMRRLQ-DFNRDLRERLESAN----RRLASKTQEAQAGSQDMVAKLLA 425
              E+  R + + E+ R Q   N  LR RL++      + LA    E Q    +  A+   
Sbjct: 1619 EAERA-REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1677

Query: 426  QSYEQ--------QQEQEK--------------LEREMALLRGAIEDQRRRAELLEQALG 463
            ++ EQ        +QE EK               E+E+  LR   E   ++ +LLE+ L 
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737

Query: 464  NAQGRAARAEEELRKKQAYVEKVE-RLQQALGQLQAACEKREQLELRLRTRLEQELKALR 522
              Q  AA A ++ ++ +A + KV   ++  L     A E+      + + RLE E    R
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797

Query: 523  -----AQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILAL-EADMTKWE------ 570
                 A + +A A         + E +A + +E  R   E++ A+ EA   K E      
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857

Query: 571  QKYLEERAMRQFAMDAA 587
            +K  E   +R+ A D A
Sbjct: 1858 EKEAENERLRRLAEDEA 1874



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 38/171 (22%), Positives = 80/171 (46%), Gaps = 2/171 (1%)

Query: 322  ARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMD 381
            A L+R+ E+LQ+E +    K+  ++ ++ E Q L E         S++++L +  R  ++
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQQSFLSEKDSLLQRERF-IE 2510

Query: 382  SEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREM 441
             E  +L+   +D   + +        + Q+ +   Q +VA +      Q + +E + R+ 
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570

Query: 442  ALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQA 492
              L+   + +R++ ELL +     + +    EE+ R   A+ E+V   Q A
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621



 Score = 36.6 bits (83), Expect = 0.092
 Identities = 68/276 (24%), Positives = 111/276 (40%), Gaps = 48/276 (17%)

Query: 319  RENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTM-- 376
            RE A+   + ++ Q E+E   +   R   L +E +++    E    A + R  LE T+  
Sbjct: 1017 RECAQRIAEQQKAQAEVEGLGKGVAR---LSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073

Query: 377  ----RNKMDSEMRRLQDFNRDLR--ERLESANRRLASKTQEAQA---------GSQDMVA 421
                R+     + +L+  +  +R  +  E   R    + +EAQA          ++  + 
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1133

Query: 422  KLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQA 481
            KL AQ+  QQ   + L  E   LRGA E   R    L+Q  G       R  E  R ++ 
Sbjct: 1134 KLRAQAEAQQPTFDALRDE---LRGAQEVGER----LQQRHGE------RDVEVERWRER 1180

Query: 482  YVEKVERLQQALGQLQAACEKREQLELRLRTRLEQE------LKALRAQQRQAGAPGGSS 535
              + +ER Q  L Q      + EQL  +LR   E        L+  R +Q Q  A     
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA----- 1235

Query: 536  GSGGSPELSALRLSEQLREKEEQILALEADMTKWEQ 571
                 P   +  + EQLR+++  +  +E    K E+
Sbjct: 1236 ----MPLADSQAVREQLRQEQALLEEIERHGEKVEE 1267


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 88/309 (28%), Positives = 137/309 (44%), Gaps = 27/309 (8%)

Query: 297  VSAQASSATSGSAHLAQMEAVLRENAR-LQRDNERLQ----RELESSAEKAGRIEKLESE 351
            + A    A +G A L      +R NA    R  E+ +    R+ + +AE+  R  + E  
Sbjct: 1898 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1957

Query: 352  IQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQE 411
            +Q+   A E   R   ++ ALE+  R K   E  R       LRER E  + R     QE
Sbjct: 1958 VQKSLAAEEEAAR--QRKAALEEVERLKAKVEEARR------LRERAEQESARQLQLAQE 2009

Query: 412  A--QAGSQDMVAKLLAQSYEQQQEQEKLEREMAL---LRGAIEDQRRRAELLEQALGNAQ 466
            A  +    +  A   A   ++Q+ Q+ L++E ++   LRG  E  RR AE  E+A   A+
Sbjct: 2010 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2069

Query: 467  GRAARAEEELRKKQAYVEKVERLQQALGQLQAACEK-REQLELRLRTRLEQELKALRAQQ 525
              AA++  ++ + +   +  E   QA  Q QAA EK R++ E     R + E  ALR +Q
Sbjct: 2070 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ 2129

Query: 526  RQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMD 585
                A               LR   Q+ E+E   L L+ + T  ++  L+E   R   + 
Sbjct: 2130 ----AADAEMEKHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQR---LK 2181

Query: 586  AAATAAAQR 594
            A AT AA++
Sbjct: 2182 AEATEAARQ 2190



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 69/307 (22%), Positives = 141/307 (45%), Gaps = 19/307 (6%)

Query: 298  SAQASSATSGSAHLAQMEAVLRENA--RLQRDNERLQRELESSAE------KAGRIEKLE 349
            + Q ++     A L Q +  L +    RLQ D E++ ++L    +      +A R  +LE
Sbjct: 2286 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2345

Query: 350  --SEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLAS 407
              +E +RL      ++RA ++ E   +  R + +    +L       R  L +  +    
Sbjct: 2346 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH------RTELATQEKVTLV 2399

Query: 408  KTQEAQAGSQDMVAKLLAQSY-EQQQEQEKLEREMALLRGAIEDQR--RRAELLEQALGN 464
            +T E Q    D  A+ L ++  E ++E+EKL++E  LL+   E+ +  ++ +LL++    
Sbjct: 2400 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2459

Query: 465  AQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQ 524
             Q   +  +  L++++   ++  +L+Q      A  ++  + + R + ++EQE + L A 
Sbjct: 2460 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2519

Query: 525  QRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAM 584
              +A      +  G   +   L+  EQ R ++E++LA E    + + + LEE+     A 
Sbjct: 2520 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2579

Query: 585  DAAATAA 591
                TA+
Sbjct: 2580 SEEVTAS 2586



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 83/331 (25%), Positives = 147/331 (44%), Gaps = 31/331 (9%)

Query: 293  VEGPVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEI 352
            VE  +  Q   A + +   AQ E   +E    QR  E + R  E++ +   +   ++ E+
Sbjct: 1333 VEAALEKQRQLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVDAQQQKRSIQEEL 1390

Query: 353  QRLSEAHESLTRASSKREALEKTMRNKMDSEMR--RLQ-DFNRDLRERLESANRRLASKT 409
            Q+L ++ E+  +A +++    +  R +++ E+R  RLQ +     R   E   + L ++ 
Sbjct: 1391 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1450

Query: 410  QEAQA---GSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQ 466
            +EA+A    +Q+   +L  Q  ++ Q + + E E+A    A  +  R  +   QAL   +
Sbjct: 1451 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1510

Query: 467  GRAARAEEELRKKQAYVEKVERLQQALGQLQAA------------CEKREQLELRLR--- 511
             +A  AE  LR  QA VE+  ++Q AL   Q +             EK  QLE  L+   
Sbjct: 1511 LQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1568

Query: 512  ---TRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREK-EEQILALEADMT 567
                +L +E  A R  Q+QA A      +    E   L+ +E LR + + + +A +  + 
Sbjct: 1569 VAVAQLREE--AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1626

Query: 568  KWEQKYLEERAMRQFAMDAAATAAAQRDTTL 598
            + E +  +E A R+      A   A R   L
Sbjct: 1627 QAEAEKQKEEAEREARRRGKAEEQAVRQREL 1657



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 79/379 (20%), Positives = 158/379 (41%), Gaps = 31/379 (8%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREA 371
            A+ E    +  + Q + ERL+R+++  +++     K ++E++  S        A  K+ A
Sbjct: 1448 ARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASRVKAEAEAAREKQRA 1502

Query: 372  LE--KTMRNKMDSEMRRLQDFN----RDLRERLESANRRLASKTQEAQAGSQDMVAKLLA 425
            L+  + +R + +   RRL+       R ++  LE+A R   ++ Q  +A   +  A+L  
Sbjct: 1503 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1562

Query: 426  QSYEQ-------QQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRK 478
               E+       ++E E+  ++ A    A E+  R  E  +     A     +AEE  ++
Sbjct: 1563 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1622

Query: 479  KQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSG 538
            K     + E+ ++   +      K E+  +R R   EQEL+    +QRQ     G++   
Sbjct: 1623 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE----KQRQLAE--GTAQQR 1676

Query: 539  GSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTL 598
             + E   +RL  +  + E+Q   LE ++ + +++       RQ      A   A+ +  L
Sbjct: 1677 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1736

Query: 599  IRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAI 658
               +     S S +E       R +    R +    ++ E+ A ++ L + ++R    A 
Sbjct: 1737 ASKARAEEESRSTSE---KSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAE 1789

Query: 659  QGSLRPAKSVPSVFAAAAA 677
            + + R       V A   A
Sbjct: 1790 EDAARQRAEAERVLAEKLA 1808



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 98/399 (24%), Positives = 175/399 (43%), Gaps = 51/399 (12%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKRE 370
            LA+  A + E  RL+ + E   +E E+  E+  R+ + E+  +R  E   +  +A  +  
Sbjct: 1803 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1862

Query: 371  ALEKTMRNKMDSEMRRLQDFNRD-LRERLESANRRLASKT--QEAQAGSQDM---VAKLL 424
              +  +R   DSE+ R +    D LR+R +     LA K   ++A AG  ++   + ++ 
Sbjct: 1863 LAQ--LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1920

Query: 425  AQSYEQQQEQEKLEREMALLRG-AIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYV 483
            + + +  + +E+ E E A  R  A E++RRR E  E+     Q   A  EE  R+++A +
Sbjct: 1921 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV----QKSLAAEEEAARQRKAAL 1976

Query: 484  EKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPEL 543
            E+VERL+  + + +           RLR R EQE     A+Q Q              + 
Sbjct: 1977 EEVERLKAKVEEAR-----------RLRERAEQE----SARQLQLAQEAAQKRLQAEEKA 2021

Query: 544  SALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDA-AATAAAQRDTTLIRHS 602
             A  + ++ +E ++    L+ + +  +Q   E  A R+ A +A  A   A+R+    R  
Sbjct: 2022 HAFAVQQKEQELQQ---TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2078

Query: 603  PQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQGSL 662
             + +      E L        +  ++ +   A+ L K+A     Q+ +RR   +A Q +L
Sbjct: 2079 VEEA------ERLKQSAEEQAQARAQAQAA-AEKLRKEAE----QEAARR--AQAEQAAL 2125

Query: 663  RPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPARLTT 701
            R  +      AA A   +  +    + RQ A     LTT
Sbjct: 2126 RQKQ------AADAEMEKHKKFAEQTLRQKAQVEQELTT 2158



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 84/351 (23%), Positives = 157/351 (44%), Gaps = 75/351 (21%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSK-- 368
            L + +AVL +    QR+ E+L R+L    E A  +     + +R  E  +++  A S+  
Sbjct: 1153 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1212

Query: 369  REAL--EKTMRNKMDSEMRRLQDFNR----------DLRERLESANRRLA-----SKTQE 411
            RE L  E+ +  +++    ++++  R          D   +L +   +L      +K  +
Sbjct: 1213 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1272

Query: 412  AQAGSQDMVA--------------------KLLAQSYEQQQEQEKL-------ERE-MAL 443
             Q+GS+ ++                     K ++++  + +E+E+L       ERE +A 
Sbjct: 1273 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1332

Query: 444  LRGAIEDQRRRAELLEQALGNAQGRAAR-----AEEELRKKQAYVEKVER---LQQALGQ 495
            +  A+E QR+ AE   QA   A+  A        EE +R+++A V+  ++   +Q+ L Q
Sbjct: 1333 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1392

Query: 496  LQAACE-----KREQLEL--RLRTRLEQELKALRAQ----QRQAGAPGGSSGSGGSPELS 544
            L+ + E     K  Q E   R R R+E+E++ +R Q    +RQ G        G   EL 
Sbjct: 1393 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG--------GAEGELQ 1444

Query: 545  ALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRD 595
            ALR   +  E +++    EA+  +  Q   E +  RQ  ++ A+   A+ +
Sbjct: 1445 ALRARAEEAEAQKRQAQEEAERLR-RQVQDESQRKRQAEVELASRVKAEAE 1494



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 74/331 (22%), Positives = 141/331 (42%), Gaps = 42/331 (12%)

Query: 313  QMEAVLRENARLQ--------RDNERLQRELESSAEK-------AGRIEKLESEIQRLSE 357
            QME + +  AR++        RD +  QR L+  AEK       A R+     E  RL +
Sbjct: 2204 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2263

Query: 358  -AHESLTR--------ASSKREALEKTMRNKMDSEMRRLQ-DFNRDLRERLESANRRLAS 407
             A E L +           K +A+++  R K ++E+ + Q +  ++   RL+    ++A 
Sbjct: 2264 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2323

Query: 408  KTQEAQAGSQDMVAKLLAQSYEQQQEQEKLE---REMALLRGAIEDQRRRAELLEQALGN 464
            +  E   G Q  +     +  E   E E+L+    EM+  +   E+  +R     + +G 
Sbjct: 2324 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2383

Query: 465  AQGRAARAEEEL--------RKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQ 516
               R   A +E          ++Q      ERL++A+ +L+   EK +Q E +L     +
Sbjct: 2384 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLKSE 2442

Query: 517  ELKALRAQQ--RQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQ-KY 573
            E++ ++ +Q  ++  A   S  S     L   R  EQ + K EQ+   + ++ K +Q + 
Sbjct: 2443 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL--FQDEVAKAQQLRE 2500

Query: 574  LEERAMRQFAMDAAATAAAQRDTTLIRHSPQ 604
             ++R  +Q   +     A+  +    +H  +
Sbjct: 2501 EQQRQQQQMEQERQRLVASMEEARRRQHEAE 2531



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 80/317 (25%), Positives = 135/317 (42%), Gaps = 43/317 (13%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEK-LESEIQRLSEAHESLTRASSKRE 370
            A+   V  E A+   + E LQ +  S AEK  ++E+ L+ E   +++  E   R + ++ 
Sbjct: 1528 ARQVQVALETAQRSAEAE-LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1586

Query: 371  ALEKTMRNKMDSEMRRLQ-DFNRDLRERLESAN----RRLASKTQEAQAGSQDMVAKLLA 425
              E+  R + + E+ R Q   N  LR RL++      + LA    E Q    +  A+   
Sbjct: 1587 EAERA-REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1645

Query: 426  QSYEQ--------QQEQEK--------------LEREMALLRGAIEDQRRRAELLEQALG 463
            ++ EQ        +QE EK               E+E+  LR   E   ++ +LLE+ L 
Sbjct: 1646 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1705

Query: 464  NAQGRAARAEEELRKKQAYVEKVE-RLQQALGQLQAACEKREQLELRLRTRLEQELKALR 522
              Q  AA A ++ ++ +A + KV   ++  L     A E+      + + RLE E    R
Sbjct: 1706 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1765

Query: 523  -----AQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILAL-EADMTKWE------ 570
                 A + +A A         + E +A + +E  R   E++ A+ EA   K E      
Sbjct: 1766 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1825

Query: 571  QKYLEERAMRQFAMDAA 587
            +K  E   +R+ A D A
Sbjct: 1826 EKEAENERLRRLAEDEA 1842



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 38/171 (22%), Positives = 80/171 (46%), Gaps = 2/171 (1%)

Query: 322  ARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMD 381
            A L+R+ E+LQ+E +    K+  ++ ++ E Q L E         S++++L +  R  ++
Sbjct: 2421 AELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQQSFLSEKDSLLQRERF-IE 2478

Query: 382  SEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREM 441
             E  +L+   +D   + +        + Q+ +   Q +VA +      Q + +E + R+ 
Sbjct: 2479 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2538

Query: 442  ALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQA 492
              L+   + +R++ ELL +     + +    EE+ R   A+ E+V   Q A
Sbjct: 2539 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2589



 Score = 36.6 bits (83), Expect = 0.092
 Identities = 68/276 (24%), Positives = 111/276 (40%), Gaps = 48/276 (17%)

Query: 319  RENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTM-- 376
            RE A+   + ++ Q E+E   +   R   L +E +++    E    A + R  LE T+  
Sbjct: 985  RECAQRIAEQQKAQAEVEGLGKGVAR---LSAEAEKVLALPEPSPAAPTLRSELELTLGK 1041

Query: 377  ----RNKMDSEMRRLQDFNRDLR--ERLESANRRLASKTQEAQA---------GSQDMVA 421
                R+     + +L+  +  +R  +  E   R    + +EAQA          ++  + 
Sbjct: 1042 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1101

Query: 422  KLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQA 481
            KL AQ+  QQ   + L  E   LRGA E   R    L+Q  G       R  E  R ++ 
Sbjct: 1102 KLRAQAEAQQPTFDALRDE---LRGAQEVGER----LQQRHGE------RDVEVERWRER 1148

Query: 482  YVEKVERLQQALGQLQAACEKREQLELRLRTRLEQE------LKALRAQQRQAGAPGGSS 535
              + +ER Q  L Q      + EQL  +LR   E        L+  R +Q Q  A     
Sbjct: 1149 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA----- 1203

Query: 536  GSGGSPELSALRLSEQLREKEEQILALEADMTKWEQ 571
                 P   +  + EQLR+++  +  +E    K E+
Sbjct: 1204 ----MPLADSQAVREQLRQEQALLEEIERHGEKVEE 1235


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 88/309 (28%), Positives = 137/309 (44%), Gaps = 27/309 (8%)

Query: 297  VSAQASSATSGSAHLAQMEAVLRENAR-LQRDNERLQ----RELESSAEKAGRIEKLESE 351
            + A    A +G A L      +R NA    R  E+ +    R+ + +AE+  R  + E  
Sbjct: 2067 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2126

Query: 352  IQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQE 411
            +Q+   A E   R   ++ ALE+  R K   E  R       LRER E  + R     QE
Sbjct: 2127 VQKSLAAEEEAAR--QRKAALEEVERLKAKVEEARR------LRERAEQESARQLQLAQE 2178

Query: 412  A--QAGSQDMVAKLLAQSYEQQQEQEKLEREMAL---LRGAIEDQRRRAELLEQALGNAQ 466
            A  +    +  A   A   ++Q+ Q+ L++E ++   LRG  E  RR AE  E+A   A+
Sbjct: 2179 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2238

Query: 467  GRAARAEEELRKKQAYVEKVERLQQALGQLQAACEK-REQLELRLRTRLEQELKALRAQQ 525
              AA++  ++ + +   +  E   QA  Q QAA EK R++ E     R + E  ALR +Q
Sbjct: 2239 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ 2298

Query: 526  RQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMD 585
                A               LR   Q+ E+E   L L+ + T  ++  L+E   R   + 
Sbjct: 2299 ----AADAEMEKHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQR---LK 2350

Query: 586  AAATAAAQR 594
            A AT AA++
Sbjct: 2351 AEATEAARQ 2359



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 69/307 (22%), Positives = 141/307 (45%), Gaps = 19/307 (6%)

Query: 298  SAQASSATSGSAHLAQMEAVLRENA--RLQRDNERLQRELESSAE------KAGRIEKLE 349
            + Q ++     A L Q +  L +    RLQ D E++ ++L    +      +A R  +LE
Sbjct: 2455 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514

Query: 350  --SEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLAS 407
              +E +RL      ++RA ++ E   +  R + +    +L       R  L +  +    
Sbjct: 2515 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH------RTELATQEKVTLV 2568

Query: 408  KTQEAQAGSQDMVAKLLAQSY-EQQQEQEKLEREMALLRGAIEDQR--RRAELLEQALGN 464
            +T E Q    D  A+ L ++  E ++E+EKL++E  LL+   E+ +  ++ +LL++    
Sbjct: 2569 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2628

Query: 465  AQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQ 524
             Q   +  +  L++++   ++  +L+Q      A  ++  + + R + ++EQE + L A 
Sbjct: 2629 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2688

Query: 525  QRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAM 584
              +A      +  G   +   L+  EQ R ++E++LA E    + + + LEE+     A 
Sbjct: 2689 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2748

Query: 585  DAAATAA 591
                TA+
Sbjct: 2749 SEEVTAS 2755



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 83/331 (25%), Positives = 147/331 (44%), Gaps = 31/331 (9%)

Query: 293  VEGPVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEI 352
            VE  +  Q   A + +   AQ E   +E    QR  E + R  E++ +   +   ++ E+
Sbjct: 1502 VEAALEKQRQLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVDAQQQKRSIQEEL 1559

Query: 353  QRLSEAHESLTRASSKREALEKTMRNKMDSEMR--RLQ-DFNRDLRERLESANRRLASKT 409
            Q+L ++ E+  +A +++    +  R +++ E+R  RLQ +     R   E   + L ++ 
Sbjct: 1560 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1619

Query: 410  QEAQA---GSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQ 466
            +EA+A    +Q+   +L  Q  ++ Q + + E E+A    A  +  R  +   QAL   +
Sbjct: 1620 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1679

Query: 467  GRAARAEEELRKKQAYVEKVERLQQALGQLQAA------------CEKREQLELRLR--- 511
             +A  AE  LR  QA VE+  ++Q AL   Q +             EK  QLE  L+   
Sbjct: 1680 LQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1737

Query: 512  ---TRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREK-EEQILALEADMT 567
                +L +E  A R  Q+QA A      +    E   L+ +E LR + + + +A +  + 
Sbjct: 1738 VAVAQLREE--AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1795

Query: 568  KWEQKYLEERAMRQFAMDAAATAAAQRDTTL 598
            + E +  +E A R+      A   A R   L
Sbjct: 1796 QAEAEKQKEEAEREARRRGKAEEQAVRQREL 1826



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 79/379 (20%), Positives = 158/379 (41%), Gaps = 31/379 (8%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREA 371
            A+ E    +  + Q + ERL+R+++  +++     K ++E++  S        A  K+ A
Sbjct: 1617 ARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASRVKAEAEAAREKQRA 1671

Query: 372  LE--KTMRNKMDSEMRRLQDFN----RDLRERLESANRRLASKTQEAQAGSQDMVAKLLA 425
            L+  + +R + +   RRL+       R ++  LE+A R   ++ Q  +A   +  A+L  
Sbjct: 1672 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1731

Query: 426  QSYEQ-------QQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRK 478
               E+       ++E E+  ++ A    A E+  R  E  +     A     +AEE  ++
Sbjct: 1732 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1791

Query: 479  KQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSG 538
            K     + E+ ++   +      K E+  +R R   EQEL+    +QRQ     G++   
Sbjct: 1792 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE----KQRQLAE--GTAQQR 1845

Query: 539  GSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTL 598
             + E   +RL  +  + E+Q   LE ++ + +++       RQ      A   A+ +  L
Sbjct: 1846 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1905

Query: 599  IRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAI 658
               +     S S +E       R +    R +    ++ E+ A ++ L + ++R    A 
Sbjct: 1906 ASKARAEEESRSTSE---KSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAE 1958

Query: 659  QGSLRPAKSVPSVFAAAAA 677
            + + R       V A   A
Sbjct: 1959 EDAARQRAEAERVLAEKLA 1977



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 98/399 (24%), Positives = 175/399 (43%), Gaps = 51/399 (12%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKRE 370
            LA+  A + E  RL+ + E   +E E+  E+  R+ + E+  +R  E   +  +A  +  
Sbjct: 1972 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 2031

Query: 371  ALEKTMRNKMDSEMRRLQDFNRD-LRERLESANRRLASKT--QEAQAGSQDM---VAKLL 424
              +  +R   DSE+ R +    D LR+R +     LA K   ++A AG  ++   + ++ 
Sbjct: 2032 LAQ--LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 2089

Query: 425  AQSYEQQQEQEKLEREMALLRG-AIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYV 483
            + + +  + +E+ E E A  R  A E++RRR E  E+     Q   A  EE  R+++A +
Sbjct: 2090 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV----QKSLAAEEEAARQRKAAL 2145

Query: 484  EKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPEL 543
            E+VERL+  + + +           RLR R EQE     A+Q Q              + 
Sbjct: 2146 EEVERLKAKVEEAR-----------RLRERAEQE----SARQLQLAQEAAQKRLQAEEKA 2190

Query: 544  SALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDA-AATAAAQRDTTLIRHS 602
             A  + ++ +E ++    L+ + +  +Q   E  A R+ A +A  A   A+R+    R  
Sbjct: 2191 HAFAVQQKEQELQQ---TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2247

Query: 603  PQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQGSL 662
             + +      E L        +  ++ +   A+ L K+A     Q+ +RR   +A Q +L
Sbjct: 2248 VEEA------ERLKQSAEEQAQARAQAQAA-AEKLRKEAE----QEAARR--AQAEQAAL 2294

Query: 663  RPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPARLTT 701
            R  +      AA A   +  +    + RQ A     LTT
Sbjct: 2295 RQKQ------AADAEMEKHKKFAEQTLRQKAQVEQELTT 2327



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 84/351 (23%), Positives = 157/351 (44%), Gaps = 75/351 (21%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSK-- 368
            L + +AVL +    QR+ E+L R+L    E A  +     + +R  E  +++  A S+  
Sbjct: 1322 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1381

Query: 369  REAL--EKTMRNKMDSEMRRLQDFNR----------DLRERLESANRRLA-----SKTQE 411
            RE L  E+ +  +++    ++++  R          D   +L +   +L      +K  +
Sbjct: 1382 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1441

Query: 412  AQAGSQDMVA--------------------KLLAQSYEQQQEQEKL-------ERE-MAL 443
             Q+GS+ ++                     K ++++  + +E+E+L       ERE +A 
Sbjct: 1442 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1501

Query: 444  LRGAIEDQRRRAELLEQALGNAQGRAAR-----AEEELRKKQAYVEKVER---LQQALGQ 495
            +  A+E QR+ AE   QA   A+  A        EE +R+++A V+  ++   +Q+ L Q
Sbjct: 1502 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1561

Query: 496  LQAACE-----KREQLEL--RLRTRLEQELKALRAQ----QRQAGAPGGSSGSGGSPELS 544
            L+ + E     K  Q E   R R R+E+E++ +R Q    +RQ G        G   EL 
Sbjct: 1562 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG--------GAEGELQ 1613

Query: 545  ALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRD 595
            ALR   +  E +++    EA+  +  Q   E +  RQ  ++ A+   A+ +
Sbjct: 1614 ALRARAEEAEAQKRQAQEEAERLR-RQVQDESQRKRQAEVELASRVKAEAE 1663



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 74/331 (22%), Positives = 141/331 (42%), Gaps = 42/331 (12%)

Query: 313  QMEAVLRENARLQ--------RDNERLQRELESSAEK-------AGRIEKLESEIQRLSE 357
            QME + +  AR++        RD +  QR L+  AEK       A R+     E  RL +
Sbjct: 2373 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2432

Query: 358  -AHESLTR--------ASSKREALEKTMRNKMDSEMRRLQ-DFNRDLRERLESANRRLAS 407
             A E L +           K +A+++  R K ++E+ + Q +  ++   RL+    ++A 
Sbjct: 2433 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2492

Query: 408  KTQEAQAGSQDMVAKLLAQSYEQQQEQEKLE---REMALLRGAIEDQRRRAELLEQALGN 464
            +  E   G Q  +     +  E   E E+L+    EM+  +   E+  +R     + +G 
Sbjct: 2493 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2552

Query: 465  AQGRAARAEEEL--------RKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQ 516
               R   A +E          ++Q      ERL++A+ +L+   EK +Q E +L     +
Sbjct: 2553 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLKSE 2611

Query: 517  ELKALRAQQ--RQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQ-KY 573
            E++ ++ +Q  ++  A   S  S     L   R  EQ + K EQ+   + ++ K +Q + 
Sbjct: 2612 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL--FQDEVAKAQQLRE 2669

Query: 574  LEERAMRQFAMDAAATAAAQRDTTLIRHSPQ 604
             ++R  +Q   +     A+  +    +H  +
Sbjct: 2670 EQQRQQQQMEQERQRLVASMEEARRRQHEAE 2700



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 80/317 (25%), Positives = 135/317 (42%), Gaps = 43/317 (13%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEK-LESEIQRLSEAHESLTRASSKRE 370
            A+   V  E A+   + E LQ +  S AEK  ++E+ L+ E   +++  E   R + ++ 
Sbjct: 1697 ARQVQVALETAQRSAEAE-LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1755

Query: 371  ALEKTMRNKMDSEMRRLQ-DFNRDLRERLESAN----RRLASKTQEAQAGSQDMVAKLLA 425
              E+  R + + E+ R Q   N  LR RL++      + LA    E Q    +  A+   
Sbjct: 1756 EAERA-REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1814

Query: 426  QSYEQ--------QQEQEK--------------LEREMALLRGAIEDQRRRAELLEQALG 463
            ++ EQ        +QE EK               E+E+  LR   E   ++ +LLE+ L 
Sbjct: 1815 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1874

Query: 464  NAQGRAARAEEELRKKQAYVEKVE-RLQQALGQLQAACEKREQLELRLRTRLEQELKALR 522
              Q  AA A ++ ++ +A + KV   ++  L     A E+      + + RLE E    R
Sbjct: 1875 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1934

Query: 523  -----AQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILAL-EADMTKWE------ 570
                 A + +A A         + E +A + +E  R   E++ A+ EA   K E      
Sbjct: 1935 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1994

Query: 571  QKYLEERAMRQFAMDAA 587
            +K  E   +R+ A D A
Sbjct: 1995 EKEAENERLRRLAEDEA 2011



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 38/171 (22%), Positives = 80/171 (46%), Gaps = 2/171 (1%)

Query: 322  ARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMD 381
            A L+R+ E+LQ+E +    K+  ++ ++ E Q L E         S++++L +  R  ++
Sbjct: 2590 AELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQQSFLSEKDSLLQRERF-IE 2647

Query: 382  SEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREM 441
             E  +L+   +D   + +        + Q+ +   Q +VA +      Q + +E + R+ 
Sbjct: 2648 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2707

Query: 442  ALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQA 492
              L+   + +R++ ELL +     + +    EE+ R   A+ E+V   Q A
Sbjct: 2708 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2758



 Score = 36.6 bits (83), Expect = 0.092
 Identities = 68/276 (24%), Positives = 111/276 (40%), Gaps = 48/276 (17%)

Query: 319  RENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTM-- 376
            RE A+   + ++ Q E+E   +   R   L +E +++    E    A + R  LE T+  
Sbjct: 1154 RECAQRIAEQQKAQAEVEGLGKGVAR---LSAEAEKVLALPEPSPAAPTLRSELELTLGK 1210

Query: 377  ----RNKMDSEMRRLQDFNRDLR--ERLESANRRLASKTQEAQA---------GSQDMVA 421
                R+     + +L+  +  +R  +  E   R    + +EAQA          ++  + 
Sbjct: 1211 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1270

Query: 422  KLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQA 481
            KL AQ+  QQ   + L  E   LRGA E   R    L+Q  G       R  E  R ++ 
Sbjct: 1271 KLRAQAEAQQPTFDALRDE---LRGAQEVGER----LQQRHGE------RDVEVERWRER 1317

Query: 482  YVEKVERLQQALGQLQAACEKREQLELRLRTRLEQE------LKALRAQQRQAGAPGGSS 535
              + +ER Q  L Q      + EQL  +LR   E        L+  R +Q Q  A     
Sbjct: 1318 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA----- 1372

Query: 536  GSGGSPELSALRLSEQLREKEEQILALEADMTKWEQ 571
                 P   +  + EQLR+++  +  +E    K E+
Sbjct: 1373 ----MPLADSQAVREQLRQEQALLEEIERHGEKVEE 1404


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 88/309 (28%), Positives = 137/309 (44%), Gaps = 27/309 (8%)

Query: 297  VSAQASSATSGSAHLAQMEAVLRENAR-LQRDNERLQ----RELESSAEKAGRIEKLESE 351
            + A    A +G A L      +R NA    R  E+ +    R+ + +AE+  R  + E  
Sbjct: 1908 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1967

Query: 352  IQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQE 411
            +Q+   A E   R   ++ ALE+  R K   E  R       LRER E  + R     QE
Sbjct: 1968 VQKSLAAEEEAAR--QRKAALEEVERLKAKVEEARR------LRERAEQESARQLQLAQE 2019

Query: 412  A--QAGSQDMVAKLLAQSYEQQQEQEKLEREMAL---LRGAIEDQRRRAELLEQALGNAQ 466
            A  +    +  A   A   ++Q+ Q+ L++E ++   LRG  E  RR AE  E+A   A+
Sbjct: 2020 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2079

Query: 467  GRAARAEEELRKKQAYVEKVERLQQALGQLQAACEK-REQLELRLRTRLEQELKALRAQQ 525
              AA++  ++ + +   +  E   QA  Q QAA EK R++ E     R + E  ALR +Q
Sbjct: 2080 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ 2139

Query: 526  RQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMD 585
                A               LR   Q+ E+E   L L+ + T  ++  L+E   R   + 
Sbjct: 2140 ----AADAEMEKHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQR---LK 2191

Query: 586  AAATAAAQR 594
            A AT AA++
Sbjct: 2192 AEATEAARQ 2200



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 69/307 (22%), Positives = 141/307 (45%), Gaps = 19/307 (6%)

Query: 298  SAQASSATSGSAHLAQMEAVLRENA--RLQRDNERLQRELESSAE------KAGRIEKLE 349
            + Q ++     A L Q +  L +    RLQ D E++ ++L    +      +A R  +LE
Sbjct: 2296 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2355

Query: 350  --SEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLAS 407
              +E +RL      ++RA ++ E   +  R + +    +L       R  L +  +    
Sbjct: 2356 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH------RTELATQEKVTLV 2409

Query: 408  KTQEAQAGSQDMVAKLLAQSY-EQQQEQEKLEREMALLRGAIEDQR--RRAELLEQALGN 464
            +T E Q    D  A+ L ++  E ++E+EKL++E  LL+   E+ +  ++ +LL++    
Sbjct: 2410 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2469

Query: 465  AQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQ 524
             Q   +  +  L++++   ++  +L+Q      A  ++  + + R + ++EQE + L A 
Sbjct: 2470 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2529

Query: 525  QRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAM 584
              +A      +  G   +   L+  EQ R ++E++LA E    + + + LEE+     A 
Sbjct: 2530 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2589

Query: 585  DAAATAA 591
                TA+
Sbjct: 2590 SEEVTAS 2596



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 83/331 (25%), Positives = 147/331 (44%), Gaps = 31/331 (9%)

Query: 293  VEGPVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEI 352
            VE  +  Q   A + +   AQ E   +E    QR  E + R  E++ +   +   ++ E+
Sbjct: 1343 VEAALEKQRQLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVDAQQQKRSIQEEL 1400

Query: 353  QRLSEAHESLTRASSKREALEKTMRNKMDSEMR--RLQ-DFNRDLRERLESANRRLASKT 409
            Q+L ++ E+  +A +++    +  R +++ E+R  RLQ +     R   E   + L ++ 
Sbjct: 1401 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1460

Query: 410  QEAQA---GSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQ 466
            +EA+A    +Q+   +L  Q  ++ Q + + E E+A    A  +  R  +   QAL   +
Sbjct: 1461 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1520

Query: 467  GRAARAEEELRKKQAYVEKVERLQQALGQLQAA------------CEKREQLELRLR--- 511
             +A  AE  LR  QA VE+  ++Q AL   Q +             EK  QLE  L+   
Sbjct: 1521 LQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1578

Query: 512  ---TRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREK-EEQILALEADMT 567
                +L +E  A R  Q+QA A      +    E   L+ +E LR + + + +A +  + 
Sbjct: 1579 VAVAQLREE--AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1636

Query: 568  KWEQKYLEERAMRQFAMDAAATAAAQRDTTL 598
            + E +  +E A R+      A   A R   L
Sbjct: 1637 QAEAEKQKEEAEREARRRGKAEEQAVRQREL 1667



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 79/379 (20%), Positives = 158/379 (41%), Gaps = 31/379 (8%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREA 371
            A+ E    +  + Q + ERL+R+++  +++     K ++E++  S        A  K+ A
Sbjct: 1458 ARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASRVKAEAEAAREKQRA 1512

Query: 372  LE--KTMRNKMDSEMRRLQDFN----RDLRERLESANRRLASKTQEAQAGSQDMVAKLLA 425
            L+  + +R + +   RRL+       R ++  LE+A R   ++ Q  +A   +  A+L  
Sbjct: 1513 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1572

Query: 426  QSYEQ-------QQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRK 478
               E+       ++E E+  ++ A    A E+  R  E  +     A     +AEE  ++
Sbjct: 1573 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1632

Query: 479  KQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSG 538
            K     + E+ ++   +      K E+  +R R   EQEL+    +QRQ     G++   
Sbjct: 1633 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE----KQRQLAE--GTAQQR 1686

Query: 539  GSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTL 598
             + E   +RL  +  + E+Q   LE ++ + +++       RQ      A   A+ +  L
Sbjct: 1687 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1746

Query: 599  IRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAI 658
               +     S S +E       R +    R +    ++ E+ A ++ L + ++R    A 
Sbjct: 1747 ASKARAEEESRSTSE---KSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAE 1799

Query: 659  QGSLRPAKSVPSVFAAAAA 677
            + + R       V A   A
Sbjct: 1800 EDAARQRAEAERVLAEKLA 1818



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 98/399 (24%), Positives = 175/399 (43%), Gaps = 51/399 (12%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKRE 370
            LA+  A + E  RL+ + E   +E E+  E+  R+ + E+  +R  E   +  +A  +  
Sbjct: 1813 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1872

Query: 371  ALEKTMRNKMDSEMRRLQDFNRD-LRERLESANRRLASKT--QEAQAGSQDM---VAKLL 424
              +  +R   DSE+ R +    D LR+R +     LA K   ++A AG  ++   + ++ 
Sbjct: 1873 LAQ--LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1930

Query: 425  AQSYEQQQEQEKLEREMALLRG-AIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYV 483
            + + +  + +E+ E E A  R  A E++RRR E  E+     Q   A  EE  R+++A +
Sbjct: 1931 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV----QKSLAAEEEAARQRKAAL 1986

Query: 484  EKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPEL 543
            E+VERL+  + + +           RLR R EQE     A+Q Q              + 
Sbjct: 1987 EEVERLKAKVEEAR-----------RLRERAEQE----SARQLQLAQEAAQKRLQAEEKA 2031

Query: 544  SALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDA-AATAAAQRDTTLIRHS 602
             A  + ++ +E ++    L+ + +  +Q   E  A R+ A +A  A   A+R+    R  
Sbjct: 2032 HAFAVQQKEQELQQ---TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2088

Query: 603  PQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQGSL 662
             + +      E L        +  ++ +   A+ L K+A     Q+ +RR   +A Q +L
Sbjct: 2089 VEEA------ERLKQSAEEQAQARAQAQAA-AEKLRKEAE----QEAARR--AQAEQAAL 2135

Query: 663  RPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPARLTT 701
            R  +      AA A   +  +    + RQ A     LTT
Sbjct: 2136 RQKQ------AADAEMEKHKKFAEQTLRQKAQVEQELTT 2168



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 84/351 (23%), Positives = 157/351 (44%), Gaps = 75/351 (21%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSK-- 368
            L + +AVL +    QR+ E+L R+L    E A  +     + +R  E  +++  A S+  
Sbjct: 1163 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1222

Query: 369  REAL--EKTMRNKMDSEMRRLQDFNR----------DLRERLESANRRLA-----SKTQE 411
            RE L  E+ +  +++    ++++  R          D   +L +   +L      +K  +
Sbjct: 1223 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1282

Query: 412  AQAGSQDMVA--------------------KLLAQSYEQQQEQEKL-------ERE-MAL 443
             Q+GS+ ++                     K ++++  + +E+E+L       ERE +A 
Sbjct: 1283 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1342

Query: 444  LRGAIEDQRRRAELLEQALGNAQGRAAR-----AEEELRKKQAYVEKVER---LQQALGQ 495
            +  A+E QR+ AE   QA   A+  A        EE +R+++A V+  ++   +Q+ L Q
Sbjct: 1343 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1402

Query: 496  LQAACE-----KREQLEL--RLRTRLEQELKALRAQ----QRQAGAPGGSSGSGGSPELS 544
            L+ + E     K  Q E   R R R+E+E++ +R Q    +RQ G        G   EL 
Sbjct: 1403 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG--------GAEGELQ 1454

Query: 545  ALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRD 595
            ALR   +  E +++    EA+  +  Q   E +  RQ  ++ A+   A+ +
Sbjct: 1455 ALRARAEEAEAQKRQAQEEAERLR-RQVQDESQRKRQAEVELASRVKAEAE 1504



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 74/331 (22%), Positives = 141/331 (42%), Gaps = 42/331 (12%)

Query: 313  QMEAVLRENARLQ--------RDNERLQRELESSAEK-------AGRIEKLESEIQRLSE 357
            QME + +  AR++        RD +  QR L+  AEK       A R+     E  RL +
Sbjct: 2214 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2273

Query: 358  -AHESLTR--------ASSKREALEKTMRNKMDSEMRRLQ-DFNRDLRERLESANRRLAS 407
             A E L +           K +A+++  R K ++E+ + Q +  ++   RL+    ++A 
Sbjct: 2274 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2333

Query: 408  KTQEAQAGSQDMVAKLLAQSYEQQQEQEKLE---REMALLRGAIEDQRRRAELLEQALGN 464
            +  E   G Q  +     +  E   E E+L+    EM+  +   E+  +R     + +G 
Sbjct: 2334 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2393

Query: 465  AQGRAARAEEEL--------RKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQ 516
               R   A +E          ++Q      ERL++A+ +L+   EK +Q E +L     +
Sbjct: 2394 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLKSE 2452

Query: 517  ELKALRAQQ--RQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQ-KY 573
            E++ ++ +Q  ++  A   S  S     L   R  EQ + K EQ+   + ++ K +Q + 
Sbjct: 2453 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL--FQDEVAKAQQLRE 2510

Query: 574  LEERAMRQFAMDAAATAAAQRDTTLIRHSPQ 604
             ++R  +Q   +     A+  +    +H  +
Sbjct: 2511 EQQRQQQQMEQERQRLVASMEEARRRQHEAE 2541



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 80/317 (25%), Positives = 135/317 (42%), Gaps = 43/317 (13%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEK-LESEIQRLSEAHESLTRASSKRE 370
            A+   V  E A+   + E LQ +  S AEK  ++E+ L+ E   +++  E   R + ++ 
Sbjct: 1538 ARQVQVALETAQRSAEAE-LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1596

Query: 371  ALEKTMRNKMDSEMRRLQ-DFNRDLRERLESAN----RRLASKTQEAQAGSQDMVAKLLA 425
              E+  R + + E+ R Q   N  LR RL++      + LA    E Q    +  A+   
Sbjct: 1597 EAERA-REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1655

Query: 426  QSYEQ--------QQEQEK--------------LEREMALLRGAIEDQRRRAELLEQALG 463
            ++ EQ        +QE EK               E+E+  LR   E   ++ +LLE+ L 
Sbjct: 1656 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1715

Query: 464  NAQGRAARAEEELRKKQAYVEKVE-RLQQALGQLQAACEKREQLELRLRTRLEQELKALR 522
              Q  AA A ++ ++ +A + KV   ++  L     A E+      + + RLE E    R
Sbjct: 1716 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1775

Query: 523  -----AQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILAL-EADMTKWE------ 570
                 A + +A A         + E +A + +E  R   E++ A+ EA   K E      
Sbjct: 1776 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1835

Query: 571  QKYLEERAMRQFAMDAA 587
            +K  E   +R+ A D A
Sbjct: 1836 EKEAENERLRRLAEDEA 1852



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 38/171 (22%), Positives = 80/171 (46%), Gaps = 2/171 (1%)

Query: 322  ARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMD 381
            A L+R+ E+LQ+E +    K+  ++ ++ E Q L E         S++++L +  R  ++
Sbjct: 2431 AELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQQSFLSEKDSLLQRERF-IE 2488

Query: 382  SEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREM 441
             E  +L+   +D   + +        + Q+ +   Q +VA +      Q + +E + R+ 
Sbjct: 2489 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2548

Query: 442  ALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQA 492
              L+   + +R++ ELL +     + +    EE+ R   A+ E+V   Q A
Sbjct: 2549 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2599



 Score = 36.6 bits (83), Expect = 0.092
 Identities = 68/276 (24%), Positives = 111/276 (40%), Gaps = 48/276 (17%)

Query: 319  RENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTM-- 376
            RE A+   + ++ Q E+E   +   R   L +E +++    E    A + R  LE T+  
Sbjct: 995  RECAQRIAEQQKAQAEVEGLGKGVAR---LSAEAEKVLALPEPSPAAPTLRSELELTLGK 1051

Query: 377  ----RNKMDSEMRRLQDFNRDLR--ERLESANRRLASKTQEAQA---------GSQDMVA 421
                R+     + +L+  +  +R  +  E   R    + +EAQA          ++  + 
Sbjct: 1052 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1111

Query: 422  KLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQA 481
            KL AQ+  QQ   + L  E   LRGA E   R    L+Q  G       R  E  R ++ 
Sbjct: 1112 KLRAQAEAQQPTFDALRDE---LRGAQEVGER----LQQRHGE------RDVEVERWRER 1158

Query: 482  YVEKVERLQQALGQLQAACEKREQLELRLRTRLEQE------LKALRAQQRQAGAPGGSS 535
              + +ER Q  L Q      + EQL  +LR   E        L+  R +Q Q  A     
Sbjct: 1159 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA----- 1213

Query: 536  GSGGSPELSALRLSEQLREKEEQILALEADMTKWEQ 571
                 P   +  + EQLR+++  +  +E    K E+
Sbjct: 1214 ----MPLADSQAVREQLRQEQALLEEIERHGEKVEE 1245


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 88/309 (28%), Positives = 137/309 (44%), Gaps = 27/309 (8%)

Query: 297  VSAQASSATSGSAHLAQMEAVLRENAR-LQRDNERLQ----RELESSAEKAGRIEKLESE 351
            + A    A +G A L      +R NA    R  E+ +    R+ + +AE+  R  + E  
Sbjct: 1916 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1975

Query: 352  IQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQE 411
            +Q+   A E   R   ++ ALE+  R K   E  R       LRER E  + R     QE
Sbjct: 1976 VQKSLAAEEEAAR--QRKAALEEVERLKAKVEEARR------LRERAEQESARQLQLAQE 2027

Query: 412  A--QAGSQDMVAKLLAQSYEQQQEQEKLEREMAL---LRGAIEDQRRRAELLEQALGNAQ 466
            A  +    +  A   A   ++Q+ Q+ L++E ++   LRG  E  RR AE  E+A   A+
Sbjct: 2028 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2087

Query: 467  GRAARAEEELRKKQAYVEKVERLQQALGQLQAACEK-REQLELRLRTRLEQELKALRAQQ 525
              AA++  ++ + +   +  E   QA  Q QAA EK R++ E     R + E  ALR +Q
Sbjct: 2088 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ 2147

Query: 526  RQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMD 585
                A               LR   Q+ E+E   L L+ + T  ++  L+E   R   + 
Sbjct: 2148 ----AADAEMEKHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQR---LK 2199

Query: 586  AAATAAAQR 594
            A AT AA++
Sbjct: 2200 AEATEAARQ 2208



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 69/307 (22%), Positives = 141/307 (45%), Gaps = 19/307 (6%)

Query: 298  SAQASSATSGSAHLAQMEAVLRENA--RLQRDNERLQRELESSAE------KAGRIEKLE 349
            + Q ++     A L Q +  L +    RLQ D E++ ++L    +      +A R  +LE
Sbjct: 2304 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2363

Query: 350  --SEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLAS 407
              +E +RL      ++RA ++ E   +  R + +    +L       R  L +  +    
Sbjct: 2364 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH------RTELATQEKVTLV 2417

Query: 408  KTQEAQAGSQDMVAKLLAQSY-EQQQEQEKLEREMALLRGAIEDQR--RRAELLEQALGN 464
            +T E Q    D  A+ L ++  E ++E+EKL++E  LL+   E+ +  ++ +LL++    
Sbjct: 2418 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2477

Query: 465  AQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQ 524
             Q   +  +  L++++   ++  +L+Q      A  ++  + + R + ++EQE + L A 
Sbjct: 2478 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2537

Query: 525  QRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAM 584
              +A      +  G   +   L+  EQ R ++E++LA E    + + + LEE+     A 
Sbjct: 2538 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2597

Query: 585  DAAATAA 591
                TA+
Sbjct: 2598 SEEVTAS 2604



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 83/331 (25%), Positives = 147/331 (44%), Gaps = 31/331 (9%)

Query: 293  VEGPVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEI 352
            VE  +  Q   A + +   AQ E   +E    QR  E + R  E++ +   +   ++ E+
Sbjct: 1351 VEAALEKQRQLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVDAQQQKRSIQEEL 1408

Query: 353  QRLSEAHESLTRASSKREALEKTMRNKMDSEMR--RLQ-DFNRDLRERLESANRRLASKT 409
            Q+L ++ E+  +A +++    +  R +++ E+R  RLQ +     R   E   + L ++ 
Sbjct: 1409 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1468

Query: 410  QEAQA---GSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQ 466
            +EA+A    +Q+   +L  Q  ++ Q + + E E+A    A  +  R  +   QAL   +
Sbjct: 1469 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1528

Query: 467  GRAARAEEELRKKQAYVEKVERLQQALGQLQAA------------CEKREQLELRLR--- 511
             +A  AE  LR  QA VE+  ++Q AL   Q +             EK  QLE  L+   
Sbjct: 1529 LQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1586

Query: 512  ---TRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREK-EEQILALEADMT 567
                +L +E  A R  Q+QA A      +    E   L+ +E LR + + + +A +  + 
Sbjct: 1587 VAVAQLREE--AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1644

Query: 568  KWEQKYLEERAMRQFAMDAAATAAAQRDTTL 598
            + E +  +E A R+      A   A R   L
Sbjct: 1645 QAEAEKQKEEAEREARRRGKAEEQAVRQREL 1675



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 79/379 (20%), Positives = 158/379 (41%), Gaps = 31/379 (8%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREA 371
            A+ E    +  + Q + ERL+R+++  +++     K ++E++  S        A  K+ A
Sbjct: 1466 ARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASRVKAEAEAAREKQRA 1520

Query: 372  LE--KTMRNKMDSEMRRLQDFN----RDLRERLESANRRLASKTQEAQAGSQDMVAKLLA 425
            L+  + +R + +   RRL+       R ++  LE+A R   ++ Q  +A   +  A+L  
Sbjct: 1521 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1580

Query: 426  QSYEQ-------QQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRK 478
               E+       ++E E+  ++ A    A E+  R  E  +     A     +AEE  ++
Sbjct: 1581 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1640

Query: 479  KQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSG 538
            K     + E+ ++   +      K E+  +R R   EQEL+    +QRQ     G++   
Sbjct: 1641 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE----KQRQLAE--GTAQQR 1694

Query: 539  GSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTL 598
             + E   +RL  +  + E+Q   LE ++ + +++       RQ      A   A+ +  L
Sbjct: 1695 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1754

Query: 599  IRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAI 658
               +     S S +E       R +    R +    ++ E+ A ++ L + ++R    A 
Sbjct: 1755 ASKARAEEESRSTSE---KSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAE 1807

Query: 659  QGSLRPAKSVPSVFAAAAA 677
            + + R       V A   A
Sbjct: 1808 EDAARQRAEAERVLAEKLA 1826



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 98/399 (24%), Positives = 175/399 (43%), Gaps = 51/399 (12%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKRE 370
            LA+  A + E  RL+ + E   +E E+  E+  R+ + E+  +R  E   +  +A  +  
Sbjct: 1821 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1880

Query: 371  ALEKTMRNKMDSEMRRLQDFNRD-LRERLESANRRLASKT--QEAQAGSQDM---VAKLL 424
              +  +R   DSE+ R +    D LR+R +     LA K   ++A AG  ++   + ++ 
Sbjct: 1881 LAQ--LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1938

Query: 425  AQSYEQQQEQEKLEREMALLRG-AIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYV 483
            + + +  + +E+ E E A  R  A E++RRR E  E+     Q   A  EE  R+++A +
Sbjct: 1939 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV----QKSLAAEEEAARQRKAAL 1994

Query: 484  EKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPEL 543
            E+VERL+  + + +           RLR R EQE     A+Q Q              + 
Sbjct: 1995 EEVERLKAKVEEAR-----------RLRERAEQE----SARQLQLAQEAAQKRLQAEEKA 2039

Query: 544  SALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDA-AATAAAQRDTTLIRHS 602
             A  + ++ +E ++    L+ + +  +Q   E  A R+ A +A  A   A+R+    R  
Sbjct: 2040 HAFAVQQKEQELQQ---TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2096

Query: 603  PQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQGSL 662
             + +      E L        +  ++ +   A+ L K+A     Q+ +RR   +A Q +L
Sbjct: 2097 VEEA------ERLKQSAEEQAQARAQAQAA-AEKLRKEAE----QEAARR--AQAEQAAL 2143

Query: 663  RPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPARLTT 701
            R  +      AA A   +  +    + RQ A     LTT
Sbjct: 2144 RQKQ------AADAEMEKHKKFAEQTLRQKAQVEQELTT 2176



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 84/351 (23%), Positives = 157/351 (44%), Gaps = 75/351 (21%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSK-- 368
            L + +AVL +    QR+ E+L R+L    E A  +     + +R  E  +++  A S+  
Sbjct: 1171 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1230

Query: 369  REAL--EKTMRNKMDSEMRRLQDFNR----------DLRERLESANRRLA-----SKTQE 411
            RE L  E+ +  +++    ++++  R          D   +L +   +L      +K  +
Sbjct: 1231 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1290

Query: 412  AQAGSQDMVA--------------------KLLAQSYEQQQEQEKL-------ERE-MAL 443
             Q+GS+ ++                     K ++++  + +E+E+L       ERE +A 
Sbjct: 1291 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1350

Query: 444  LRGAIEDQRRRAELLEQALGNAQGRAAR-----AEEELRKKQAYVEKVER---LQQALGQ 495
            +  A+E QR+ AE   QA   A+  A        EE +R+++A V+  ++   +Q+ L Q
Sbjct: 1351 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1410

Query: 496  LQAACE-----KREQLEL--RLRTRLEQELKALRAQ----QRQAGAPGGSSGSGGSPELS 544
            L+ + E     K  Q E   R R R+E+E++ +R Q    +RQ G        G   EL 
Sbjct: 1411 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG--------GAEGELQ 1462

Query: 545  ALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRD 595
            ALR   +  E +++    EA+  +  Q   E +  RQ  ++ A+   A+ +
Sbjct: 1463 ALRARAEEAEAQKRQAQEEAERLR-RQVQDESQRKRQAEVELASRVKAEAE 1512



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 74/331 (22%), Positives = 141/331 (42%), Gaps = 42/331 (12%)

Query: 313  QMEAVLRENARLQ--------RDNERLQRELESSAEK-------AGRIEKLESEIQRLSE 357
            QME + +  AR++        RD +  QR L+  AEK       A R+     E  RL +
Sbjct: 2222 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2281

Query: 358  -AHESLTR--------ASSKREALEKTMRNKMDSEMRRLQ-DFNRDLRERLESANRRLAS 407
             A E L +           K +A+++  R K ++E+ + Q +  ++   RL+    ++A 
Sbjct: 2282 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2341

Query: 408  KTQEAQAGSQDMVAKLLAQSYEQQQEQEKLE---REMALLRGAIEDQRRRAELLEQALGN 464
            +  E   G Q  +     +  E   E E+L+    EM+  +   E+  +R     + +G 
Sbjct: 2342 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2401

Query: 465  AQGRAARAEEEL--------RKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQ 516
               R   A +E          ++Q      ERL++A+ +L+   EK +Q E +L     +
Sbjct: 2402 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLKSE 2460

Query: 517  ELKALRAQQ--RQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQ-KY 573
            E++ ++ +Q  ++  A   S  S     L   R  EQ + K EQ+   + ++ K +Q + 
Sbjct: 2461 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL--FQDEVAKAQQLRE 2518

Query: 574  LEERAMRQFAMDAAATAAAQRDTTLIRHSPQ 604
             ++R  +Q   +     A+  +    +H  +
Sbjct: 2519 EQQRQQQQMEQERQRLVASMEEARRRQHEAE 2549



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 80/317 (25%), Positives = 135/317 (42%), Gaps = 43/317 (13%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEK-LESEIQRLSEAHESLTRASSKRE 370
            A+   V  E A+   + E LQ +  S AEK  ++E+ L+ E   +++  E   R + ++ 
Sbjct: 1546 ARQVQVALETAQRSAEAE-LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1604

Query: 371  ALEKTMRNKMDSEMRRLQ-DFNRDLRERLESAN----RRLASKTQEAQAGSQDMVAKLLA 425
              E+  R + + E+ R Q   N  LR RL++      + LA    E Q    +  A+   
Sbjct: 1605 EAERA-REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1663

Query: 426  QSYEQ--------QQEQEK--------------LEREMALLRGAIEDQRRRAELLEQALG 463
            ++ EQ        +QE EK               E+E+  LR   E   ++ +LLE+ L 
Sbjct: 1664 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1723

Query: 464  NAQGRAARAEEELRKKQAYVEKVE-RLQQALGQLQAACEKREQLELRLRTRLEQELKALR 522
              Q  AA A ++ ++ +A + KV   ++  L     A E+      + + RLE E    R
Sbjct: 1724 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1783

Query: 523  -----AQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILAL-EADMTKWE------ 570
                 A + +A A         + E +A + +E  R   E++ A+ EA   K E      
Sbjct: 1784 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1843

Query: 571  QKYLEERAMRQFAMDAA 587
            +K  E   +R+ A D A
Sbjct: 1844 EKEAENERLRRLAEDEA 1860



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 38/171 (22%), Positives = 80/171 (46%), Gaps = 2/171 (1%)

Query: 322  ARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMD 381
            A L+R+ E+LQ+E +    K+  ++ ++ E Q L E         S++++L +  R  ++
Sbjct: 2439 AELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQQSFLSEKDSLLQRERF-IE 2496

Query: 382  SEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREM 441
             E  +L+   +D   + +        + Q+ +   Q +VA +      Q + +E + R+ 
Sbjct: 2497 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2556

Query: 442  ALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQA 492
              L+   + +R++ ELL +     + +    EE+ R   A+ E+V   Q A
Sbjct: 2557 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2607



 Score = 36.6 bits (83), Expect = 0.092
 Identities = 68/276 (24%), Positives = 111/276 (40%), Gaps = 48/276 (17%)

Query: 319  RENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTM-- 376
            RE A+   + ++ Q E+E   +   R   L +E +++    E    A + R  LE T+  
Sbjct: 1003 RECAQRIAEQQKAQAEVEGLGKGVAR---LSAEAEKVLALPEPSPAAPTLRSELELTLGK 1059

Query: 377  ----RNKMDSEMRRLQDFNRDLR--ERLESANRRLASKTQEAQA---------GSQDMVA 421
                R+     + +L+  +  +R  +  E   R    + +EAQA          ++  + 
Sbjct: 1060 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1119

Query: 422  KLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQA 481
            KL AQ+  QQ   + L  E   LRGA E   R    L+Q  G       R  E  R ++ 
Sbjct: 1120 KLRAQAEAQQPTFDALRDE---LRGAQEVGER----LQQRHGE------RDVEVERWRER 1166

Query: 482  YVEKVERLQQALGQLQAACEKREQLELRLRTRLEQE------LKALRAQQRQAGAPGGSS 535
              + +ER Q  L Q      + EQL  +LR   E        L+  R +Q Q  A     
Sbjct: 1167 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA----- 1221

Query: 536  GSGGSPELSALRLSEQLREKEEQILALEADMTKWEQ 571
                 P   +  + EQLR+++  +  +E    K E+
Sbjct: 1222 ----MPLADSQAVREQLRQEQALLEEIERHGEKVEE 1253


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 88/309 (28%), Positives = 137/309 (44%), Gaps = 27/309 (8%)

Query: 297  VSAQASSATSGSAHLAQMEAVLRENAR-LQRDNERLQ----RELESSAEKAGRIEKLESE 351
            + A    A +G A L      +R NA    R  E+ +    R+ + +AE+  R  + E  
Sbjct: 1957 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2016

Query: 352  IQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQE 411
            +Q+   A E   R   ++ ALE+  R K   E  R       LRER E  + R     QE
Sbjct: 2017 VQKSLAAEEEAAR--QRKAALEEVERLKAKVEEARR------LRERAEQESARQLQLAQE 2068

Query: 412  A--QAGSQDMVAKLLAQSYEQQQEQEKLEREMAL---LRGAIEDQRRRAELLEQALGNAQ 466
            A  +    +  A   A   ++Q+ Q+ L++E ++   LRG  E  RR AE  E+A   A+
Sbjct: 2069 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2128

Query: 467  GRAARAEEELRKKQAYVEKVERLQQALGQLQAACEK-REQLELRLRTRLEQELKALRAQQ 525
              AA++  ++ + +   +  E   QA  Q QAA EK R++ E     R + E  ALR +Q
Sbjct: 2129 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ 2188

Query: 526  RQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMD 585
                A               LR   Q+ E+E   L L+ + T  ++  L+E   R   + 
Sbjct: 2189 ----AADAEMEKHKKFAEQTLRQKAQV-EQELTTLRLQLEETDHQKNLLDEELQR---LK 2240

Query: 586  AAATAAAQR 594
            A AT AA++
Sbjct: 2241 AEATEAARQ 2249



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 69/307 (22%), Positives = 141/307 (45%), Gaps = 19/307 (6%)

Query: 298  SAQASSATSGSAHLAQMEAVLRENA--RLQRDNERLQRELESSAE------KAGRIEKLE 349
            + Q ++     A L Q +  L +    RLQ D E++ ++L    +      +A R  +LE
Sbjct: 2345 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2404

Query: 350  --SEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLAS 407
              +E +RL      ++RA ++ E   +  R + +    +L       R  L +  +    
Sbjct: 2405 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH------RTELATQEKVTLV 2458

Query: 408  KTQEAQAGSQDMVAKLLAQSY-EQQQEQEKLEREMALLRGAIEDQR--RRAELLEQALGN 464
            +T E Q    D  A+ L ++  E ++E+EKL++E  LL+   E+ +  ++ +LL++    
Sbjct: 2459 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2518

Query: 465  AQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQ 524
             Q   +  +  L++++   ++  +L+Q      A  ++  + + R + ++EQE + L A 
Sbjct: 2519 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2578

Query: 525  QRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAM 584
              +A      +  G   +   L+  EQ R ++E++LA E    + + + LEE+     A 
Sbjct: 2579 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2638

Query: 585  DAAATAA 591
                TA+
Sbjct: 2639 SEEVTAS 2645



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 83/331 (25%), Positives = 147/331 (44%), Gaps = 31/331 (9%)

Query: 293  VEGPVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEI 352
            VE  +  Q   A + +   AQ E   +E    QR  E + R  E++ +   +   ++ E+
Sbjct: 1392 VEAALEKQRQLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVDAQQQKRSIQEEL 1449

Query: 353  QRLSEAHESLTRASSKREALEKTMRNKMDSEMR--RLQ-DFNRDLRERLESANRRLASKT 409
            Q+L ++ E+  +A +++    +  R +++ E+R  RLQ +     R   E   + L ++ 
Sbjct: 1450 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1509

Query: 410  QEAQA---GSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQ 466
            +EA+A    +Q+   +L  Q  ++ Q + + E E+A    A  +  R  +   QAL   +
Sbjct: 1510 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1569

Query: 467  GRAARAEEELRKKQAYVEKVERLQQALGQLQAA------------CEKREQLELRLR--- 511
             +A  AE  LR  QA VE+  ++Q AL   Q +             EK  QLE  L+   
Sbjct: 1570 LQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1627

Query: 512  ---TRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREK-EEQILALEADMT 567
                +L +E  A R  Q+QA A      +    E   L+ +E LR + + + +A +  + 
Sbjct: 1628 VAVAQLREE--AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1685

Query: 568  KWEQKYLEERAMRQFAMDAAATAAAQRDTTL 598
            + E +  +E A R+      A   A R   L
Sbjct: 1686 QAEAEKQKEEAEREARRRGKAEEQAVRQREL 1716



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 79/379 (20%), Positives = 158/379 (41%), Gaps = 31/379 (8%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREA 371
            A+ E    +  + Q + ERL+R+++  +++     K ++E++  S        A  K+ A
Sbjct: 1507 ARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASRVKAEAEAAREKQRA 1561

Query: 372  LE--KTMRNKMDSEMRRLQDFN----RDLRERLESANRRLASKTQEAQAGSQDMVAKLLA 425
            L+  + +R + +   RRL+       R ++  LE+A R   ++ Q  +A   +  A+L  
Sbjct: 1562 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1621

Query: 426  QSYEQ-------QQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRK 478
               E+       ++E E+  ++ A    A E+  R  E  +     A     +AEE  ++
Sbjct: 1622 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1681

Query: 479  KQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSG 538
            K     + E+ ++   +      K E+  +R R   EQEL+    +QRQ     G++   
Sbjct: 1682 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE----KQRQLAE--GTAQQR 1735

Query: 539  GSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTL 598
             + E   +RL  +  + E+Q   LE ++ + +++       RQ      A   A+ +  L
Sbjct: 1736 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1795

Query: 599  IRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAI 658
               +     S S +E       R +    R +    ++ E+ A ++ L + ++R    A 
Sbjct: 1796 ASKARAEEESRSTSE---KSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAE 1848

Query: 659  QGSLRPAKSVPSVFAAAAA 677
            + + R       V A   A
Sbjct: 1849 EDAARQRAEAERVLAEKLA 1867



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 98/399 (24%), Positives = 175/399 (43%), Gaps = 51/399 (12%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKRE 370
            LA+  A + E  RL+ + E   +E E+  E+  R+ + E+  +R  E   +  +A  +  
Sbjct: 1862 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1921

Query: 371  ALEKTMRNKMDSEMRRLQDFNRD-LRERLESANRRLASKT--QEAQAGSQDM---VAKLL 424
              +  +R   DSE+ R +    D LR+R +     LA K   ++A AG  ++   + ++ 
Sbjct: 1922 LAQ--LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1979

Query: 425  AQSYEQQQEQEKLEREMALLRG-AIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYV 483
            + + +  + +E+ E E A  R  A E++RRR E  E+     Q   A  EE  R+++A +
Sbjct: 1980 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV----QKSLAAEEEAARQRKAAL 2035

Query: 484  EKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPEL 543
            E+VERL+  + + +           RLR R EQE     A+Q Q              + 
Sbjct: 2036 EEVERLKAKVEEAR-----------RLRERAEQE----SARQLQLAQEAAQKRLQAEEKA 2080

Query: 544  SALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDA-AATAAAQRDTTLIRHS 602
             A  + ++ +E ++    L+ + +  +Q   E  A R+ A +A  A   A+R+    R  
Sbjct: 2081 HAFAVQQKEQELQQ---TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2137

Query: 603  PQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQGSL 662
             + +      E L        +  ++ +   A+ L K+A     Q+ +RR   +A Q +L
Sbjct: 2138 VEEA------ERLKQSAEEQAQARAQAQAA-AEKLRKEAE----QEAARR--AQAEQAAL 2184

Query: 663  RPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPARLTT 701
            R  +      AA A   +  +    + RQ A     LTT
Sbjct: 2185 RQKQ------AADAEMEKHKKFAEQTLRQKAQVEQELTT 2217



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 84/351 (23%), Positives = 157/351 (44%), Gaps = 75/351 (21%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSK-- 368
            L + +AVL +    QR+ E+L R+L    E A  +     + +R  E  +++  A S+  
Sbjct: 1212 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1271

Query: 369  REAL--EKTMRNKMDSEMRRLQDFNR----------DLRERLESANRRLA-----SKTQE 411
            RE L  E+ +  +++    ++++  R          D   +L +   +L      +K  +
Sbjct: 1272 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1331

Query: 412  AQAGSQDMVA--------------------KLLAQSYEQQQEQEKL-------ERE-MAL 443
             Q+GS+ ++                     K ++++  + +E+E+L       ERE +A 
Sbjct: 1332 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1391

Query: 444  LRGAIEDQRRRAELLEQALGNAQGRAAR-----AEEELRKKQAYVEKVER---LQQALGQ 495
            +  A+E QR+ AE   QA   A+  A        EE +R+++A V+  ++   +Q+ L Q
Sbjct: 1392 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1451

Query: 496  LQAACE-----KREQLEL--RLRTRLEQELKALRAQ----QRQAGAPGGSSGSGGSPELS 544
            L+ + E     K  Q E   R R R+E+E++ +R Q    +RQ G        G   EL 
Sbjct: 1452 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG--------GAEGELQ 1503

Query: 545  ALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRD 595
            ALR   +  E +++    EA+  +  Q   E +  RQ  ++ A+   A+ +
Sbjct: 1504 ALRARAEEAEAQKRQAQEEAERLR-RQVQDESQRKRQAEVELASRVKAEAE 1553



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 74/331 (22%), Positives = 141/331 (42%), Gaps = 42/331 (12%)

Query: 313  QMEAVLRENARLQ--------RDNERLQRELESSAEK-------AGRIEKLESEIQRLSE 357
            QME + +  AR++        RD +  QR L+  AEK       A R+     E  RL +
Sbjct: 2263 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2322

Query: 358  -AHESLTR--------ASSKREALEKTMRNKMDSEMRRLQ-DFNRDLRERLESANRRLAS 407
             A E L +           K +A+++  R K ++E+ + Q +  ++   RL+    ++A 
Sbjct: 2323 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2382

Query: 408  KTQEAQAGSQDMVAKLLAQSYEQQQEQEKLE---REMALLRGAIEDQRRRAELLEQALGN 464
            +  E   G Q  +     +  E   E E+L+    EM+  +   E+  +R     + +G 
Sbjct: 2383 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2442

Query: 465  AQGRAARAEEEL--------RKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQ 516
               R   A +E          ++Q      ERL++A+ +L+   EK +Q E +L     +
Sbjct: 2443 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLKSE 2501

Query: 517  ELKALRAQQ--RQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQ-KY 573
            E++ ++ +Q  ++  A   S  S     L   R  EQ + K EQ+   + ++ K +Q + 
Sbjct: 2502 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL--FQDEVAKAQQLRE 2559

Query: 574  LEERAMRQFAMDAAATAAAQRDTTLIRHSPQ 604
             ++R  +Q   +     A+  +    +H  +
Sbjct: 2560 EQQRQQQQMEQERQRLVASMEEARRRQHEAE 2590



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 80/317 (25%), Positives = 135/317 (42%), Gaps = 43/317 (13%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEK-LESEIQRLSEAHESLTRASSKRE 370
            A+   V  E A+   + E LQ +  S AEK  ++E+ L+ E   +++  E   R + ++ 
Sbjct: 1587 ARQVQVALETAQRSAEAE-LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1645

Query: 371  ALEKTMRNKMDSEMRRLQ-DFNRDLRERLESAN----RRLASKTQEAQAGSQDMVAKLLA 425
              E+  R + + E+ R Q   N  LR RL++      + LA    E Q    +  A+   
Sbjct: 1646 EAERA-REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1704

Query: 426  QSYEQ--------QQEQEK--------------LEREMALLRGAIEDQRRRAELLEQALG 463
            ++ EQ        +QE EK               E+E+  LR   E   ++ +LLE+ L 
Sbjct: 1705 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1764

Query: 464  NAQGRAARAEEELRKKQAYVEKVE-RLQQALGQLQAACEKREQLELRLRTRLEQELKALR 522
              Q  AA A ++ ++ +A + KV   ++  L     A E+      + + RLE E    R
Sbjct: 1765 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1824

Query: 523  -----AQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILAL-EADMTKWE------ 570
                 A + +A A         + E +A + +E  R   E++ A+ EA   K E      
Sbjct: 1825 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1884

Query: 571  QKYLEERAMRQFAMDAA 587
            +K  E   +R+ A D A
Sbjct: 1885 EKEAENERLRRLAEDEA 1901



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 38/171 (22%), Positives = 80/171 (46%), Gaps = 2/171 (1%)

Query: 322  ARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMD 381
            A L+R+ E+LQ+E +    K+  ++ ++ E Q L E         S++++L +  R  ++
Sbjct: 2480 AELEREKEKLQQEAKLLQLKSEEMQTVQQE-QLLQETQALQQSFLSEKDSLLQRERF-IE 2537

Query: 382  SEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREM 441
             E  +L+   +D   + +        + Q+ +   Q +VA +      Q + +E + R+ 
Sbjct: 2538 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2597

Query: 442  ALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQA 492
              L+   + +R++ ELL +     + +    EE+ R   A+ E+V   Q A
Sbjct: 2598 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2648



 Score = 36.6 bits (83), Expect = 0.092
 Identities = 68/276 (24%), Positives = 111/276 (40%), Gaps = 48/276 (17%)

Query: 319  RENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTM-- 376
            RE A+   + ++ Q E+E   +   R   L +E +++    E    A + R  LE T+  
Sbjct: 1044 RECAQRIAEQQKAQAEVEGLGKGVAR---LSAEAEKVLALPEPSPAAPTLRSELELTLGK 1100

Query: 377  ----RNKMDSEMRRLQDFNRDLR--ERLESANRRLASKTQEAQA---------GSQDMVA 421
                R+     + +L+  +  +R  +  E   R    + +EAQA          ++  + 
Sbjct: 1101 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1160

Query: 422  KLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQA 481
            KL AQ+  QQ   + L  E   LRGA E   R    L+Q  G       R  E  R ++ 
Sbjct: 1161 KLRAQAEAQQPTFDALRDE---LRGAQEVGER----LQQRHGE------RDVEVERWRER 1207

Query: 482  YVEKVERLQQALGQLQAACEKREQLELRLRTRLEQE------LKALRAQQRQAGAPGGSS 535
              + +ER Q  L Q      + EQL  +LR   E        L+  R +Q Q  A     
Sbjct: 1208 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA----- 1262

Query: 536  GSGGSPELSALRLSEQLREKEEQILALEADMTKWEQ 571
                 P   +  + EQLR+++  +  +E    K E+
Sbjct: 1263 ----MPLADSQAVREQLRQEQALLEEIERHGEKVEE 1294


>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 62/273 (22%), Positives = 132/273 (48%), Gaps = 22/273 (8%)

Query: 313 QMEAVLRENARLQRDNERLQRELESSAEKAGRI----EKLESEIQRLSEAHESLTRASSK 368
           Q E +  +  ++ R  E+++ + E   E+  ++    EK+  + +++ E  E + R   K
Sbjct: 337 QEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEK 396

Query: 369 REALEKTMRNKMDSEMRRLQDFNRDLRE------RLESANRRLASKTQEAQAGSQDMVAK 422
               E+  + KM  + +++++ +  +RE      R E   R L    Q+ +   +++  K
Sbjct: 397 IREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEK 456

Query: 423 LLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELL--EQALGNAQGRAARAEEEL---- 476
           +  +  + Q+++EK++R+   ++   E   R+ +LL  E+ +   + +  R EE++    
Sbjct: 457 MQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQE 516

Query: 477 RKKQAYVEKVERLQQALGQLQAAC----EKREQLELRLRTRLEQELKALRAQQRQAGAPG 532
            K Q   EK++R ++ + + +       EK ++ E+RL+  LE+ L  L  +    G  G
Sbjct: 517 EKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQ-ELEERLGKLGQKAELLGGAG 575

Query: 533 GSSGSGGSPELSALRLSEQLREKEEQILALEAD 565
             SGS   P L+ + L  +L+ +E Q L  + D
Sbjct: 576 RESGSQRLPTLTPI-LQVELKSQEAQSLQQQQD 607



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 53/271 (19%), Positives = 121/271 (44%), Gaps = 11/271 (4%)

Query: 313 QMEAVLRENARLQRDNERL---QRELESSAEKAGRIE-KLESEIQRLSEAHESLTRASSK 368
           Q E + R+  ++Q   E++   + ++    EK  R E K+  + +++ E  + + R   K
Sbjct: 295 QEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEK 354

Query: 369 REALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSY 428
               E+ +R + + +M R ++  R+  E+++     +  + ++ +   +    K+  Q  
Sbjct: 355 IREQEEKIREQ-EEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEK 413

Query: 429 EQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVER 488
           + +++ EK+  +   +    E  R   E+++      +    + +EE  K Q   EK++R
Sbjct: 414 KMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQR 473

Query: 489 LQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRL 548
            ++ + + +    ++E+L  +     EQE K  R +++               E    R 
Sbjct: 474 QEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKM----WEQEEKMQEQEEKMQRQ 529

Query: 549 SEQLREKEEQILALEADMTKWEQKY--LEER 577
            E++RE+E ++   E  M + E +   LEER
Sbjct: 530 EEKMREQEVRLWQQEEKMQEQEVRLQELEER 560



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 57/274 (20%), Positives = 123/274 (44%), Gaps = 30/274 (10%)

Query: 312 AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREA 371
           AQ+E     N   Q+  E++ R+ E   E+    EK+  +  ++ E  E + R   K   
Sbjct: 280 AQVEENELWNLLNQQQEEKMWRQEEKIQEQE---EKMCEQELKIREQEEKMWRQEEKMHE 336

Query: 372 LEKTMRNKMDSEMR---RLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSY 428
            E+ +R + D   R   ++++    +RE+ E   R+   K +E     Q+   ++  Q  
Sbjct: 337 QEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQ-EEKIREQDEKIQEQEEEMWRQEE 395

Query: 429 EQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKV-E 487
           + ++++EK + +M      + +Q  +    E+ +   + +    EE ++ ++  + +V E
Sbjct: 396 KIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEE 455

Query: 488 RLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALR 547
           ++Q+   ++Q   EK ++ E +++   EQE K  R ++                    L+
Sbjct: 456 KMQEEEEKMQEQEEKIQRQEEKIQ---EQEEKTWRQEK-------------------LLK 493

Query: 548 LSEQLREKEEQILALEADMTKWEQKYLEERAMRQ 581
             E++ E+EE++   E  M + E+K  E+    Q
Sbjct: 494 QEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQ 527



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 60/286 (20%), Positives = 128/286 (44%), Gaps = 22/286 (7%)

Query: 377 RNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMV-----AKLLAQSYEQQ 431
           RN +  E   L++ N +L+E+L    R + S+  E Q   +D+      A+LL    + Q
Sbjct: 208 RNTITDE--ELKEKNAELQEKL----RLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQ 261

Query: 432 QEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYV-EKVERLQ 490
            E ++L +E+  +   ++ Q    EL        + +  R EE++++++  + E+  +++
Sbjct: 262 VEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIR 321

Query: 491 QALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSE 550
           +   ++    EK  + E ++R   EQE K  R +++               E    R  E
Sbjct: 322 EQEEKMWRQEEKMHEQEEKIR---EQEDKMWRQEEKIRE----QEEKIREQEEKMWRQEE 374

Query: 551 QLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSS 610
           ++RE++E+I   E +M + E+K  E+   RQ  M        ++D  +     Q      
Sbjct: 375 KIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKI---REQEEEMWR 431

Query: 611 FNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGK 656
             E +       Q+ E +L+ +  ++ E++  ++  +++ +R   K
Sbjct: 432 QEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEK 477


>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 62/273 (22%), Positives = 132/273 (48%), Gaps = 22/273 (8%)

Query: 313 QMEAVLRENARLQRDNERLQRELESSAEKAGRI----EKLESEIQRLSEAHESLTRASSK 368
           Q E +  +  ++ R  E+++ + E   E+  ++    EK+  + +++ E  E + R   K
Sbjct: 337 QEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEK 396

Query: 369 REALEKTMRNKMDSEMRRLQDFNRDLRE------RLESANRRLASKTQEAQAGSQDMVAK 422
               E+  + KM  + +++++ +  +RE      R E   R L    Q+ +   +++  K
Sbjct: 397 IREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEK 456

Query: 423 LLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELL--EQALGNAQGRAARAEEEL---- 476
           +  +  + Q+++EK++R+   ++   E   R+ +LL  E+ +   + +  R EE++    
Sbjct: 457 MQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQE 516

Query: 477 RKKQAYVEKVERLQQALGQLQAAC----EKREQLELRLRTRLEQELKALRAQQRQAGAPG 532
            K Q   EK++R ++ + + +       EK ++ E+RL+  LE+ L  L  +    G  G
Sbjct: 517 EKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQ-ELEERLGKLGQKAELLGGAG 575

Query: 533 GSSGSGGSPELSALRLSEQLREKEEQILALEAD 565
             SGS   P L+ + L  +L+ +E Q L  + D
Sbjct: 576 RESGSQRLPTLTPI-LQVELKSQEAQSLQQQQD 607



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 53/271 (19%), Positives = 121/271 (44%), Gaps = 11/271 (4%)

Query: 313 QMEAVLRENARLQRDNERL---QRELESSAEKAGRIE-KLESEIQRLSEAHESLTRASSK 368
           Q E + R+  ++Q   E++   + ++    EK  R E K+  + +++ E  + + R   K
Sbjct: 295 QEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEK 354

Query: 369 REALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSY 428
               E+ +R + + +M R ++  R+  E+++     +  + ++ +   +    K+  Q  
Sbjct: 355 IREQEEKIREQ-EEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEK 413

Query: 429 EQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVER 488
           + +++ EK+  +   +    E  R   E+++      +    + +EE  K Q   EK++R
Sbjct: 414 KMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQR 473

Query: 489 LQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRL 548
            ++ + + +    ++E+L  +     EQE K  R +++               E    R 
Sbjct: 474 QEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKM----WEQEEKMQEQEEKMQRQ 529

Query: 549 SEQLREKEEQILALEADMTKWEQKY--LEER 577
            E++RE+E ++   E  M + E +   LEER
Sbjct: 530 EEKMREQEVRLWQQEEKMQEQEVRLQELEER 560



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 57/274 (20%), Positives = 123/274 (44%), Gaps = 30/274 (10%)

Query: 312 AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREA 371
           AQ+E     N   Q+  E++ R+ E   E+    EK+  +  ++ E  E + R   K   
Sbjct: 280 AQVEENELWNLLNQQQEEKMWRQEEKIQEQE---EKMCEQELKIREQEEKMWRQEEKMHE 336

Query: 372 LEKTMRNKMDSEMR---RLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSY 428
            E+ +R + D   R   ++++    +RE+ E   R+   K +E     Q+   ++  Q  
Sbjct: 337 QEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQ-EEKIREQDEKIQEQEEEMWRQEE 395

Query: 429 EQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKV-E 487
           + ++++EK + +M      + +Q  +    E+ +   + +    EE ++ ++  + +V E
Sbjct: 396 KIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEE 455

Query: 488 RLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALR 547
           ++Q+   ++Q   EK ++ E +++   EQE K  R ++                    L+
Sbjct: 456 KMQEEEEKMQEQEEKIQRQEEKIQ---EQEEKTWRQEK-------------------LLK 493

Query: 548 LSEQLREKEEQILALEADMTKWEQKYLEERAMRQ 581
             E++ E+EE++   E  M + E+K  E+    Q
Sbjct: 494 QEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQ 527



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 72/333 (21%), Positives = 148/333 (44%), Gaps = 31/333 (9%)

Query: 336 ESSAEKAGRIEKLESEIQ-----RLSEAHESLTRASSKREALEKTM-RNKMDSEMRRLQD 389
           E +A+K      LE  +      R+    E LT+   +R+AL   + RN +  E   L++
Sbjct: 164 EVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTK---ERDALSLELYRNTITDE--ELKE 218

Query: 390 FNRDLRERLESANRRLASKTQEAQAGSQDMV-----AKLLAQSYEQQQEQEKLEREMALL 444
            N +L+E+L    R + S+  E Q   +D+      A+LL    + Q E ++L +E+  +
Sbjct: 219 KNAELQEKL----RLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSV 274

Query: 445 RGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYV-EKVERLQQALGQLQAACEKR 503
              ++ Q    EL        + +  R EE++++++  + E+  ++++   ++    EK 
Sbjct: 275 SAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKM 334

Query: 504 EQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALE 563
            + E ++R   EQE K  R +++               E    R  E++RE++E+I   E
Sbjct: 335 HEQEEKIR---EQEDKMWRQEEKIRE----QEEKIREQEEKMWRQEEKIREQDEKIQEQE 387

Query: 564 ADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQ 623
            +M + E+K  E+   RQ  M        ++D  +     Q        E +       Q
Sbjct: 388 EEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKI---REQEEEMWRQEEKIRELEEMMQ 444

Query: 624 EMESRLKVLHAQILEKDAVIKVLQQRSRRDPGK 656
           + E +L+ +  ++ E++  ++  +++ +R   K
Sbjct: 445 DQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEK 477


>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
          Length = 2028

 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 79/309 (25%), Positives = 140/309 (45%), Gaps = 58/309 (18%)

Query: 297 VSAQASSATSGSAHLAQMEAVLRENARLQR---DNERLQRELESSAEKAGRIEKLESEIQ 353
           VS++A        + A  + V   N +L +   +  +L R+LE + EK  R EKLE E+Q
Sbjct: 579 VSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ 638

Query: 354 RLSEAHESLTR-------ASSKREALE----------KTMRNKMDSEMRRLQDFNRDLRE 396
           RL E +  L R       A+ K EALE          +T+R  +D+    LQ+ +  L E
Sbjct: 639 RLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDT----LQNVSLQL-E 693

Query: 397 RLESANRRLASKTQEAQAGSQDM------VAKLLAQSYEQQQEQEKLEREMALLRGAIED 450
            LE  N++L ++  E +   + M      +A++  ++ + ++E+E+L + + LL+     
Sbjct: 694 GLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKAL--- 750

Query: 451 QRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRL 510
             +++E LE +  +      R ++ L        K + L+  LG+L+A            
Sbjct: 751 -GKKSERLELSYQSVSAENLRLQQSLESSS---HKTQTLESELGELEAE----------- 795

Query: 511 RTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWE 570
           R  L ++L+ALR    Q          G   +  AL       EK++++L  EA    W+
Sbjct: 796 RQALRRDLEALRLANAQL--------EGAEKDRKALEQEVAQLEKDKKLLEKEAKRL-WQ 846

Query: 571 QKYLEERAM 579
           Q  L++  +
Sbjct: 847 QVELKDAVL 855



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 116/509 (22%), Positives = 196/509 (38%), Gaps = 67/509 (13%)

Query: 308 SAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASS 367
           SAHL      L +NA L  D  R     E +   + RI KLE E Q L    + L  AS 
Sbjct: 429 SAHLGWELEQLSKNADLS-DASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASL 487

Query: 368 KREA-------LEKTMRN------KMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQA 414
             E        LEK          K+ +++ R +  N+DL    E+ +  L  + ++ Q+
Sbjct: 488 VLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDL----ETLSEELIREKEQLQS 543

Query: 415 GSQDMVAKLLAQSYEQQQEQEKLEREMALLR--------GAIEDQRRRAELLEQALGNAQ 466
             + + A    Q  + +QE++ L R M  LR          ++D  +  + L Q +  A 
Sbjct: 544 DMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEAN 603

Query: 467 GRAARAE----------EELRKKQAYVEKVER----LQQALGQ-------LQAACEKREQ 505
           G+ ++ E          E+ ++K    EK+ER    LQ+  G+       L+ A EK E 
Sbjct: 604 GKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEA 663

Query: 506 LE-----LRLRTR-LEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQI 559
           LE     L+L  R L + L  L+    Q       +    +  L   RL E +R    ++
Sbjct: 664 LEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKL 723

Query: 560 LALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGG 619
             +E +  + E++  E R      +D       + +   + +    + +    + L +  
Sbjct: 724 AQMERENQQLEREKEELRK----NVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSS 779

Query: 620 HRHQEMESRLKVLHA--QILEKDAVIKVL---QQRSRRDPGKAIQGSLRPAKSVPSVFAA 674
           H+ Q +ES L  L A  Q L +D     L   Q        KA++  +   +    +   
Sbjct: 780 HKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEK 839

Query: 675 AAAGTQGWQGLSSSERQTADAPARLTTAD---RAPTEEPVVTAPPAAHAKHGSRDGSTQT 731
            A   + WQ +   +    D+ A+L+  +   RA  +E       A   K   +D    T
Sbjct: 840 EA--KRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLT 897

Query: 732 EGPPDSTSTCLPPEPDSLLGCSSSQRAAS 760
           +       T      D +L    SQ+ +S
Sbjct: 898 KQVTVHARTLTTLREDLVLEKLKSQQLSS 926



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 73/296 (24%), Positives = 129/296 (43%), Gaps = 31/296 (10%)

Query: 297  VSAQASSATSGSAHL-AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRL 355
            +  + S+ +S SA L AQ   +   +   + +NE LQR+ E   +     E L  + + L
Sbjct: 1118 LQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQE---QLTAAYEALLQDHEHL 1174

Query: 356  SEAHESLTRASSKREAL------EKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKT 409
               HE   R S++ EAL       KT+   ++ E + L + + D+ +R      R    T
Sbjct: 1175 GTLHE---RQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLT 1231

Query: 410  QEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMAL---LRGAIEDQRRRAELLEQALGNAQ 466
             E +A  Q+     LA   E Q+ + +L+R   L   L+G  E+     + L+ +L NAQ
Sbjct: 1232 TEREALQQEQRTNALAMG-ENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQ 1290

Query: 467  GRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQR 526
                    EL + QA  ++++   Q +       +   +L  RL+  LE+E   L +Q +
Sbjct: 1291 -------LELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQ 1343

Query: 527  QAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQF 582
                    S          +   EQ  E+++Q +     + + ++K LEE+ M Q+
Sbjct: 1344 LL------SQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEK-LEEKIMDQY 1392



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 76/359 (21%), Positives = 142/359 (39%), Gaps = 52/359 (14%)

Query: 313 QMEAVLRENARLQRD--NERLQR-ELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKR 369
           +++ V +EN +L  D  + R  R EL+S  EKA R+E+LE E+ R  E    +    ++ 
Sbjct: 290 ELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARM 349

Query: 370 EALEK-----TMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAG---SQDMVA 421
           E L +          M  E         D    LE  N +L SK  + +      +  + 
Sbjct: 350 EELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIE 409

Query: 422 KLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGN--------AQGRAARAE 473
           +LL ++   +  Q++   E A L   +E   + A+L + +  +        A  R  + E
Sbjct: 410 ELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLE 469

Query: 474 EELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGG 533
           +E +  Q+ ++ +      L +    C + E+   +L  ++E+    L  +++       
Sbjct: 470 KENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQ------- 522

Query: 534 SSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQ 593
                 + +L  L   E +REKE+    L++DM     + L+    RQ            
Sbjct: 523 -----SNQDLETLS-EELIREKEQ----LQSDM-----ETLKADKARQIKDLEQEKDHLN 567

Query: 594 RDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRR 652
           R    +R   Q S  +           R +++E   K LH  + E +  +  L+   R+
Sbjct: 568 RAMWSLRERSQVSSEA-----------RMKDVEKENKALHQTVTEANGKLSQLEFEKRQ 615



 Score = 30.4 bits (67), Expect = 6.6
 Identities = 40/197 (20%), Positives = 76/197 (38%), Gaps = 28/197 (14%)

Query: 340  EKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLE 399
            EKA    +LESE+Q L +  E+L +   + + L+ + ++                     
Sbjct: 988  EKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAG------------------ 1029

Query: 400  SANRRLASKTQEAQA---GSQDMVAKLLA---QSYEQQQEQEKLEREMALLRGAIEDQRR 453
                + A+  Q  +A   G ++   +LL    ++ E ++    L+ E  LL+  ++    
Sbjct: 1030 ----KTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLET 1085

Query: 454  RAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTR 513
            +       +   Q ++A  +E     Q    K++     L    AA   +  L     T 
Sbjct: 1086 QNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTA 1145

Query: 514  LEQELKALRAQQRQAGA 530
             E E ++L+ QQ Q  A
Sbjct: 1146 KETENESLQRQQEQLTA 1162


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 108/447 (24%), Positives = 182/447 (40%), Gaps = 109/447 (24%)

Query: 253 PVFLQQQQQYQYLQQSQEHPPP---PHPAALGHGPLSSLSPPAVEGPVSAQASSATSGSA 309
           P  LQ +     L+  QE  PP    H  A  +G L        EG   ++ S     S 
Sbjct: 287 PTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILR-------EGSSESETSVRRKVSL 339

Query: 310 HLAQMEAVLRENA----------RLQRDNERLQRELESSAEKAGRIEKLESEIQR-LSEA 358
            L +M+ ++  ++           L R  E LQR+L+   +K  ++E  +  ++R L E 
Sbjct: 340 VLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEK 399

Query: 359 HESLTRASS--KREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQA-- 414
            E  +R     +R   E    NK    M+RL D   DLR  LE+    L +K +  Q   
Sbjct: 400 TEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPE 459

Query: 415 GSQDMVAKLLAQSYE--------QQQEQEKL---EREMALLRGAIEDQ------------ 451
            +++++ K L ++ E        +Q+ +E+L   ERE+  L+GA++++            
Sbjct: 460 PAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVR 519

Query: 452 ---RRRAELLEQALGNAQGRAARAEEELRKKQAYV------------------------- 483
              +R  E L +++ +A    A  E E +K  A V                         
Sbjct: 520 QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNK 579

Query: 484 -------------------------EKVERLQQALGQLQAACEKREQLELRLR--TRLEQ 516
                                    EK+E LQ+ L Q +A+     Q+E+  +   R ++
Sbjct: 580 EDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQE 639

Query: 517 ELKALRAQQRQAGAPGGSSGSGGSPELSALRL-SEQLREKEEQILALEADMTKWEQKYLE 575
           ELK L+A+++     G         +L+ LR+ +++ RE EEQ L L+  + +  Q   E
Sbjct: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQD-CE 698

Query: 576 ERAMRQFAMDAAATAAAQR----DTTL 598
           E +  +   +A AT   QR    +TTL
Sbjct: 699 EASKAKMVAEAEATVLGQRRAAVETTL 725



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 80/360 (22%), Positives = 155/360 (43%), Gaps = 62/360 (17%)

Query: 314  MEAVLRENA-RLQRDNERLQRELESSAEKAGRIEKLESEIQ-RLSEAHESLTRASSKREA 371
            +EA LR+   RL+ + ++L+  L +S E+ G +   +  ++ RL EA   L R   +++ 
Sbjct: 759  VEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQT 818

Query: 372  LEKTMRN--KMDSEMRR----LQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLA 425
            L + +    K    +RR    L++  R L   ++  N+ L    ++++   Q + A+L  
Sbjct: 819  LNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQL-- 876

Query: 426  QSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEK 485
                 +  +EK  RE+A       D +R+A+          G  +R ++E          
Sbjct: 877  -----EDYKEKARREVA-------DAQRQAKDWASEAEKTSGGLSRLQDE---------- 914

Query: 486  VERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSA 545
            ++RL+QAL   QA          R   RL++EL A R Q        G      + + S 
Sbjct: 915  IQRLRQALQASQAE---------RDTARLDKELLAQRLQ--------GLEQEAENKKRSQ 957

Query: 546  LRLSEQLREKEEQILALEADMTKWEQ--KYLEERAMR------QFAMDAAATAAAQRD-- 595
               + QL+  EE++  LE ++ + +   + L +R  R      Q   +     +A++D  
Sbjct: 958  DDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLE 1017

Query: 596  ---TTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRR 652
                +L R +       + +EG         ++ES+ ++L  ++  ++    VLQ  +R+
Sbjct: 1018 CDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRK 1077



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 57/252 (22%), Positives = 117/252 (46%), Gaps = 28/252 (11%)

Query: 283  GPLSSLSPPAVEGPVSAQASSATSGSAHL------AQMEAVLRENARLQRDNERLQRELE 336
            G LS L         + QAS A   +A L       +++ + +E    +R  +   R+L+
Sbjct: 906  GGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLK 965

Query: 337  SSAEKAGRIE-KLESEIQRLSEAHESLTRASSKREAL------EKTMRNKMDSEMRRLQD 389
               EK  R+E +L+ E   +    + + R   + + L      E++ R  ++ +   L+ 
Sbjct: 966  GLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLER 1025

Query: 390  FNRDLRERLESAN--RRLASKTQEAQAGSQDMVAKLLAQSYEQ---QQEQEKLEREMALL 444
             N+DL+ RL S+   ++ ++   + ++ +Q +  +L A+  E+   Q    KLER++  L
Sbjct: 1026 QNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKEL 1085

Query: 445  RGAIEDQRR----RAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQAAC 500
               IED+R+    + + L   +   + +   AEEE+ +     +K +R      +++   
Sbjct: 1086 SIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQR------EVEEQH 1139

Query: 501  EKREQLELRLRT 512
            E  EQL+ R+++
Sbjct: 1140 EVNEQLQARIKS 1151



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 60/226 (26%), Positives = 96/226 (42%), Gaps = 31/226 (13%)

Query: 329 ERLQRELESSAEKAG---RIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMR 385
           E LQRELE +   AG   ++E L+ E+ R  E  + L      +E   +    +++ ++ 
Sbjct: 608 EVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLA 667

Query: 386 RLQ---DFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMA 442
            L+   D  R+L E+     + L    Q+ +  S+   AK++A++      Q +   E  
Sbjct: 668 VLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASK---AKMVAEAEATVLGQRRAAVETT 724

Query: 443 LLRGAIEDQ--RRRAELLEQALGNAQGRA-------ARAEEELRK----KQAYVEKVERL 489
           L     E+   RRR   LEQ L   +G         AR  ++L++    KQ   E +   
Sbjct: 725 LRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNAS 784

Query: 490 QQALGQLQAACEKREQLELRLR------TRLEQELKALRAQQRQAG 529
           Q+  G L AA   +  LE RL        RL QE + L     + G
Sbjct: 785 QEEEGSLAAA---KRALEARLEEAQRGLARLGQEQQTLNRALEEEG 827


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 80/308 (25%), Positives = 138/308 (44%), Gaps = 34/308 (11%)

Query: 310  HLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQR-LSEAHESLTRASSK 368
            H  Q +  ++E   LQ   E L+ E+E+      +IEK  S++ R L E  E L  AS  
Sbjct: 1104 HSLQFQKKIKE---LQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGA 1160

Query: 369  REALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSY 428
              A +  M  K ++E ++++   RDL E     +   A+  ++ QA   D VA+L  Q  
Sbjct: 1161 TSA-QIEMNKKREAEFQKMR---RDL-EEATLQHEATAATLRKKQA---DSVAELGEQID 1212

Query: 429  EQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVE---- 484
              Q+ ++KLE+E + L+  I+D     E L ++  N +      E++  + +A  E    
Sbjct: 1213 NLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQ 1272

Query: 485  -------KVERLQQALGQLQAACEKREQLELRL---RTRLEQELKALRAQ-QRQAGAPGG 533
                   +  RLQ   G+L    E++E L  +L   +  L Q+L+ L+ Q + +  A   
Sbjct: 1273 LIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNA 1332

Query: 534  SSGSGGSPELSALRLSEQLREKEEQILALE-------ADMTKWEQKYLEERAMRQFAMDA 586
             + +  S       L EQ  E++E    L+       +++ +W  KY  +   R   ++ 
Sbjct: 1333 MAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEE 1392

Query: 587  AATAAAQR 594
            A    AQR
Sbjct: 1393 AKKKLAQR 1400



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 80/354 (22%), Positives = 152/354 (42%), Gaps = 37/354 (10%)

Query: 323  RLQRDNERLQRELESSAEKAGRIEKLESEIQR-LSEAHESLTRASSKREALEKTMRNKMD 381
            RLQ + E L R+LE S      ++K +    + L+E  + L  + ++ EA +K  R+ + 
Sbjct: 1424 RLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRS-LS 1482

Query: 382  SEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREM 441
            +E+ ++++   ++ ++LE+  RR     QE  +   + +A+      E ++ ++ +E+E 
Sbjct: 1483 TELFKMRNAYEEVVDQLETL-RRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEK 1541

Query: 442  ALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACE 501
            + L+ A+E+     E  E  +   Q   ++ + EL +K   +EK E ++Q     Q A E
Sbjct: 1542 SDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRK--VIEKDEEIEQLKRNSQRAAE 1599

Query: 502  KREQL----------ELRLRTRLEQELKALRAQ-----QRQAGAPGGSSGSGGSPELSAL 546
              + +           LRL+ ++E +L  +  Q     ++ A          G  + S L
Sbjct: 1600 ALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQL 1659

Query: 547  RLSEQLREKE---EQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSP 603
             L + LR  E   EQ+  +E    +     LEE    + A++         +  L+  S 
Sbjct: 1660 HLDDALRSNEDLKEQLAIVE----RRNGLLLEELEEMKVALEQTERTRRLSEQELLDASD 1715

Query: 604  QPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKA 657
            +     S N  L+          +  K L A I +  A ++   Q SR    KA
Sbjct: 1716 RVQLLHSQNTSLI----------NTKKKLEADIAQCQAEVENSIQESRNAEEKA 1759



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 47/232 (20%), Positives = 97/232 (41%), Gaps = 28/232 (12%)

Query: 313  QMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREAL 372
            Q++ + R   +L+++   L+ E++  A     + K +S I+R     E        ++  
Sbjct: 1210 QIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQ 1269

Query: 373  EKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQ 432
            +  + + ++ +  RLQ  N +L  R+E     ++  T+  QA +Q      L +   Q +
Sbjct: 1270 QTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQ-----LEELKRQME 1324

Query: 433  EQEKLEREMA-----------LLRGAIEDQRRRAELLEQALGNAQGRAA----------- 470
            E+ K +  MA           LLR   E+++     L++AL  A    A           
Sbjct: 1325 EETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAI 1384

Query: 471  -RAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKAL 521
             R EE    K+   ++++  ++      + C   E+ + RL+  +E  ++ L
Sbjct: 1385 QRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDL 1436



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 75/345 (21%), Positives = 146/345 (42%), Gaps = 48/345 (13%)

Query: 293  VEGPVSAQASSATSGSAHLAQMEAVL--------RENARLQRDNERLQRELES------- 337
            VEG +  + S        L+Q+++ L         E  +L+R+++R    L+S       
Sbjct: 1551 VEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIR 1610

Query: 338  SAEKAGRIEK-LESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDF---NRD 393
            S   A R++K +E ++  +        R  ++ +   +T++ ++      L D    N D
Sbjct: 1611 SRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNED 1670

Query: 394  LRERLESANRR---LASKTQEAQAG-----------------SQDMVAKLLAQSYEQQQE 433
            L+E+L    RR   L  + +E +                   + D V  L +Q+      
Sbjct: 1671 LKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINT 1730

Query: 434  QEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQ---AYVEKVER-L 489
            ++KLE ++A  +  +E+  + +   E+    A   AA   EEL+K+Q   A++E++++ L
Sbjct: 1731 KKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1790

Query: 490  QQALGQLQAACEKREQLEL----RLRTRLEQELKALRAQQRQAGAPGGSSGSGGSP-ELS 544
            +Q +  LQ   ++ EQL L    +   +LE  ++ L  +       G  +  G    E  
Sbjct: 1791 EQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERK 1850

Query: 545  ALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAAT 589
               ++ Q  E  + IL L+  + K + K    +   + A + A T
Sbjct: 1851 VKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANT 1895



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 61/227 (26%), Positives = 98/227 (43%), Gaps = 28/227 (12%)

Query: 313  QMEAVLRENARLQR-----DNERLQRELESSAEKAGRIEKLESE----IQRLSEAHESLT 363
            Q E      A LQR     ++E  Q   +   +   R E+LE       QRL EA E+  
Sbjct: 1350 QYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTE 1409

Query: 364  RASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKL 423
             A+SK  +LEKT + ++  E   ++D  RDL ER  +A   L  K +       +   KL
Sbjct: 1410 TANSKCASLEKT-KQRLQGE---VEDLMRDL-ERSHTACATLDKKQRNFDKVLAEWKQKL 1464

Query: 424  ---LAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQ 480
                A+    Q+E   L  E+  +R A E+   + E L +   N Q   +   E++ +  
Sbjct: 1465 DESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETG 1524

Query: 481  AYVEKVER-----------LQQALGQLQAACEKREQLELRLRTRLEQ 516
              +++ E+           LQ AL +++ + E  E   LR++  L Q
Sbjct: 1525 KNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQ 1571



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 64/275 (23%), Positives = 121/275 (44%), Gaps = 40/275 (14%)

Query: 323  RLQRDNERLQRELESSAEKAGRIE----KLESEIQRLSEAHES----LTRASSKREALEK 374
            +++++    + ++++ +E+   +E    KL  E + L EAH+     L     K   L K
Sbjct: 967  KVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIK 1026

Query: 375  TMRNKMDSEMRRLQ---DFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQ 431
             +  K++ +   L+   +  + LR  LE A R+L    + +Q    D+         ++Q
Sbjct: 1027 -INAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDL-------ENDKQ 1078

Query: 432  QEQEKLER---EMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKK---QAYVEK 485
            Q +EKL++   E++ L+  I+D++  +   ++ +   Q R    EEE+  +   +A +EK
Sbjct: 1079 QIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEK 1138

Query: 486  ------------VERLQQALGQLQAACE---KREQLELRLRTRLEQELKALRAQQRQAGA 530
                         ERL++A G   A  E   KRE    ++R  LE+      A       
Sbjct: 1139 QRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK 1198

Query: 531  PGGSSGSGGSPELSALRLSEQLREKEEQILALEAD 565
                S +    ++  L+  +Q  EKE+  L +E D
Sbjct: 1199 KQADSVAELGEQIDNLQRVKQKLEKEKSELKMEID 1233



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 53/243 (21%), Positives = 99/243 (40%), Gaps = 28/243 (11%)

Query: 349  ESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASK 408
            E E+  + E  E      ++ EA  K +  KM S ++   D    L+ + E+ N   A +
Sbjct: 850  EKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQ--LQVQSETENLMDAEE 907

Query: 409  TQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQ----RRRAELLEQALGN 464
              E    S+ ++   + +  E+ +E+E++  E+   +  +ED+    +R  + LE  L  
Sbjct: 908  RCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTK 967

Query: 465  -------AQGRAARAEEELRKKQAYVEKV--------ERLQQALGQLQAACEKREQLELR 509
                    + +     EE+   +  + K+        E  QQ L  LQ   +K   L ++
Sbjct: 968  VEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGL-IK 1026

Query: 510  LRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKW 569
            +  +LEQ+   L     Q              E +  +L   L+  +E I+ LE D  + 
Sbjct: 1027 INAKLEQQTDDLEGSLEQ------EKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQI 1080

Query: 570  EQK 572
            E+K
Sbjct: 1081 EEK 1083


>gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo
           sapiens]
          Length = 1002

 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 88/351 (25%), Positives = 149/351 (42%), Gaps = 62/351 (17%)

Query: 265 LQQSQEHPPPPHPAALGHGPLSSLSPPAVEGPVSAQASSATSGSAHLA-QMEAVLREN-- 321
           L+     PPPP P A          P  VE  + A+A         LA Q++A +++N  
Sbjct: 442 LRNQMAEPPPPEPPA---------GPSEVEQQLQAEAEHLRKELEGLAGQLQAQVQDNEG 492

Query: 322 -ARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKM 380
            +RL R+ E    ELE +AE  G                    +A ++R+ LE TM+N  
Sbjct: 493 LSRLNREQEERLLELERAAELWGE-------------------QAEARRQILE-TMQNDR 532

Query: 381 DSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKL--- 437
            +  R L   NR+L+E+L          T E    + ++ + L ++ + +++  +KL   
Sbjct: 533 TTISRALSQ-NRELKEQLAELQSGFVKLTNE----NMEITSALQSEQHVKRELGKKLGEL 587

Query: 438 EREMALLRGAIEDQRRRAELLEQA----LGNAQGRAARAEEELRKKQA-------YVEKV 486
           + +++ L+  +E + + A+ L+Q     LG+ Q   A  ++   +K+          + V
Sbjct: 588 QEKLSELKETVELKSQEAQSLQQQRDQYLGHLQQYVAAYQQLTSEKEVLHNQLLLQTQLV 647

Query: 487 ERLQQALGQLQAACEKREQLELRLRTRLE---QELKALRAQQRQAGAPGGSSGSGGSPEL 543
           ++LQQ   Q +A  E   Q     + RLE   Q+ + LRAQ      PG   G     E 
Sbjct: 648 DQLQQQEAQGKAVAEMARQELQETQERLEAATQQNQQLRAQLSLMAHPGEGDGLDREEE- 706

Query: 544 SALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQR 594
                 E   E+EE+ +A+   M    +      AM  F   A A+A  ++
Sbjct: 707 ------EDEEEEEEEAVAVPQPMPSIPEDLESREAMVAFFNSAVASAEEEQ 751



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 87/403 (21%), Positives = 161/403 (39%), Gaps = 58/403 (14%)

Query: 297 VSAQASSATSGSAHLAQMEAVLR----ENARLQRDNERLQRELESS-----AEKAGRIEK 347
           VS Q   A   +  L +    LR    +N +   D ++ + ELE        EKAG    
Sbjct: 275 VSTQQKKADRYNKELTKERDALRLELYKNTQSNEDLKQEKSELEEKLRVLVTEKAGMQLN 334

Query: 348 LESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLAS 407
           LE   ++L      L + SS+ EA +   + +   E R           +LE+   ++  
Sbjct: 335 LEELQKKLEMTELLLQQFSSRCEAPDANQQLQQAMEERA----------QLEAHLGQVME 384

Query: 408 KTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQG 467
             ++ Q         L  +S   +Q  +++  ++  LR   E    R + LE +L   + 
Sbjct: 385 SVRQLQMERDKYAENLKGESAMWRQRMQQMSEQVHTLREEKECSMSRVQELETSLAELRN 444

Query: 468 RAAR------------AEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLE 515
           + A              E++L+ +  ++ K   L+   GQLQA  +  E L    R + E
Sbjct: 445 QMAEPPPPEPPAGPSEVEQQLQAEAEHLRK--ELEGLAGQLQAQVQDNEGLSRLNREQEE 502

Query: 516 QELKALRAQQ---RQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQK 572
           + L+  RA +    QA A      +  +   +  R   Q RE +EQ+  L++   K   +
Sbjct: 503 RLLELERAAELWGEQAEARRQILETMQNDRTTISRALSQNRELKEQLAELQSGFVKLTNE 562

Query: 573 YLE-----------ERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGH- 620
            +E           +R + +   +     +  ++T  ++     S     ++ L   GH 
Sbjct: 563 NMEITSALQSEQHVKRELGKKLGELQEKLSELKETVELKSQEAQSLQQQRDQYL---GHL 619

Query: 621 -----RHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAI 658
                 +Q++ S  +VLH Q+L +  ++  LQQ+  +  GKA+
Sbjct: 620 QQYVAAYQQLTSEKEVLHNQLLLQTQLVDQLQQQEAQ--GKAV 660



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 119/563 (21%), Positives = 201/563 (35%), Gaps = 68/563 (12%)

Query: 52  QASLEILAPEDSQVLQQATRQEPQGQEHQG----------------GENHLAENTLYRLC 95
           Q S    AP+ +Q LQQA  +  Q + H G                 EN   E+ ++R  
Sbjct: 351 QFSSRCEAPDANQQLQQAMEERAQLEAHLGQVMESVRQLQMERDKYAENLKGESAMWRQR 410

Query: 96  PQPSKGEELPTYEEAKAHS----QYYAAQQAGTRPHAGDRDPRGAPGGSRRQDEALR-EL 150
            Q    E++ T  E K  S    Q      A  R    +  P   P G    ++ L+ E 
Sbjct: 411 MQ-QMSEQVHTLREEKECSMSRVQELETSLAELRNQMAEPPPPEPPAGPSEVEQQLQAEA 469

Query: 151 RHGHVRSLSERLLQLSLERNGARAPSHMSSSHSFPQLARNQQGPPLRGPPAEGPESRGPP 210
            H          L+  LE    +  + +  +    +L R Q+   L    A   E  G  
Sbjct: 470 EH----------LRKELEGLAGQLQAQVQDNEGLSRLNREQEERLLELERAA--ELWGEQ 517

Query: 211 PQYPHVVLAHETTTAVTDPRYRARGSPHFQHAEVRILQAQVPPVFLQ---QQQQYQYLQQ 267
            +    +L        T  R  +      Q+ E++   A++   F++   +  +     Q
Sbjct: 518 AEARRQILETMQNDRTTISRALS------QNRELKEQLAELQSGFVKLTNENMEITSALQ 571

Query: 268 SQEHPPPPHPAALGH--GPLSSLSPPAVEGPVSAQASSATSGSAHLAQMEAVLRENARLQ 325
           S++H        LG     LS L    VE       S       +L  ++  +    +L 
Sbjct: 572 SEQHVKRELGKKLGELQEKLSELKE-TVELKSQEAQSLQQQRDQYLGHLQQYVAAYQQLT 630

Query: 326 RDNERLQRELESSAEKAGRIEKLESE--------IQRLSEAHESLTRASSKREALEKTMR 377
            + E L  +L    +   ++++ E++         Q L E  E L  A+ + + L   + 
Sbjct: 631 SEKEVLHNQLLLQTQLVDQLQQQEAQGKAVAEMARQELQETQERLEAATQQNQQLRAQL- 689

Query: 378 NKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKL 437
             + +        +R+  E  E       +  Q   +  +D+ ++    ++         
Sbjct: 690 -SLMAHPGEGDGLDREEEEDEEEEEEEAVAVPQPMPSIPEDLESREAMVAFFNSAVASA- 747

Query: 438 EREMALLRGAIEDQRRRAELLEQALGNAQ--GRAARAEEELRKKQAYVEKVERLQQALGQ 495
           E E A LRG +++QR R   L   L +AQ    AA             E    LQ A+ +
Sbjct: 748 EEEQARLRGQLKEQRVRCRRLAHLLASAQKEPEAAAPAPGTGGDSVCGETHRALQGAMEK 807

Query: 496 LQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALR---LSEQL 552
           LQ+   +  Q +  L+ R+E+       + R     G +   G    L   +   L E+ 
Sbjct: 808 LQSRFMELMQEKADLKERVEE------LEHRCIQLSGETDTIGEYIALYQSQRAVLKERH 861

Query: 553 REKEEQILALEADMTKWEQKYLE 575
           REKEE I  L  D  + + K LE
Sbjct: 862 REKEEYISRLAQDKEEMKVKLLE 884


>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
          Length = 1476

 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 154/617 (24%), Positives = 238/617 (38%), Gaps = 117/617 (18%)

Query: 16   IQEQLRYGNLTETRTLLAIQQQALRGGAGT--GGTGSPQASLEILAPEDSQVLQQ----- 68
            +Q+++R       RTL   + + LRG      G  G     LE  AP +  VL       
Sbjct: 449  LQDEVREAEAGRLRTLER-ENRELRGLLQVLQGQPGGQHPLLE--APREDPVLPVLEEAP 505

Query: 69   ----ATRQEPQG---QEHQGGEN--HLAENTLYRLCPQPSKGEELPTYEEAKAHSQYYAA 119
                A    PQG   +   GG     LA   L  +    ++  + P  +  +A S     
Sbjct: 506  QTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPL--- 562

Query: 120  QQAGTRPHAGDRDPR--GAPGGSRRQDEALRELRHGHVRSLSERLLQLSLERNGAR--AP 175
            Q A   P A D  P+  G+P  ++   E     + G   SL         +  G +  AP
Sbjct: 563  QAAAMDPQASDWSPQESGSPVETQESPE-----KAGRRSSLQSPASVAPPQGPGTKIQAP 617

Query: 176  SHMSSSHSFPQLARNQQGPPLRGPPAEGPESRGPPPQYPHVVLAHETTTAVTDPRYRARG 235
              +       +  + +  P   G   EGPE + P P  P  V   E            + 
Sbjct: 618  QLLGGETEGREAPQGELVPEAWGLRQEGPEHK-PGPSEPSSVQLEE------------QE 664

Query: 236  SPHFQHAEVRILQAQVPPVFLQQQQQYQYLQQSQEHPPPPHPAALGHGPLSSLSPPAVEG 295
             P+ Q  ++   QA+        ++  Q L+ +   P    P     G   +L     EG
Sbjct: 665  GPN-QGLDLATGQAEA-------REHDQRLEGTVRDPAWQKPQQKSEG---ALEVQVWEG 713

Query: 296  PVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRL 355
            P+  +  S  SG   +A+ EA+  E A+L+R  E L  ELE+ A K   +E   +E  RL
Sbjct: 714  PIPGE--SLASG---VAEQEALREEVAQLRRKAEALGDELEAQARK---LEAQNTEAARL 765

Query: 356  SEAHESLTRASSK--REALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQ 413
            S+      RA ++  REA  +                   LRE +E+A + L S +QE +
Sbjct: 766  SKELAQARRAEAEAHREAEAQAWEQAR-------------LREAVEAAGQELESASQERE 812

Query: 414  AGSQDMVA-------------KLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQ 460
            A  + + A             +L AQS   ++  + LE E        E +RR  E L+ 
Sbjct: 813  ALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQA 872

Query: 461  ALGNAQGR------------------AARAEEELRKKQAYVEKVERLQQAL-GQLQAACE 501
             L  A  R                  A   +E LR+K++  ++ + L+Q L  +LQAA  
Sbjct: 873  ELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAAT 932

Query: 502  KREQLELRLRTR---LEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQ 558
             +E+  + L+TR   LE+EL  LR  Q  AG            E   +RL E   E+   
Sbjct: 933  SKEEALMELKTRALQLEEELFQLR--QGPAGLGPKKRAEPQLVETQNVRLIEV--ERSNA 988

Query: 559  ILALEADMTKWEQKYLE 575
            +L  E    + + ++LE
Sbjct: 989  MLVAEKAALQGQLQHLE 1005



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 66/264 (25%), Positives = 116/264 (43%), Gaps = 50/264 (18%)

Query: 296 PVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRL 355
           P +   + A   S HLA   A     A+L+R  + L+ + E   +    ++ LE+EI+RL
Sbjct: 241 PEAPSRAPAEGPSHHLALQLA--NAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRL 298

Query: 356 SEAHESLTRASSKREAL--EKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQ 413
            +  ++L+  + + E    E     +    + RLQ+  R  RERL++A            
Sbjct: 299 RQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAA------------ 346

Query: 414 AGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAE 473
                       ++Y+ Q E+E++      L G +E  +    LLE+ L  A+ R AR  
Sbjct: 347 ------------EAYKSQLEEERV------LSGVLEASKA---LLEEQLEAARERCARLH 385

Query: 474 EELRKKQAYVEKVERLQQALGQLQAACEK-REQLELRLRTRLEQELKALRAQQRQAGAPG 532
           E  R+          L+  LG+  A  +  R Q++      +E EL+  R+ +   G+PG
Sbjct: 386 ETQRENLL-------LRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPG 438

Query: 533 GSSGSGGSPELSALRLSEQLREKE 556
            +  +G +P      L +++RE E
Sbjct: 439 EAPLAGAAPS-----LQDEVREAE 457



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 81/312 (25%), Positives = 143/312 (45%), Gaps = 37/312 (11%)

Query: 283  GPLSSLSPPAVEGPVSAQASSATSGSAHLAQMEAVLR-ENARLQRDNERLQRELESSAEK 341
            G L SL   A E  +  Q+  A   S+ L   ++VL  +   L R  E L+ E+ ++ + 
Sbjct: 1006 GQLGSLQGRAQE--LLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQS 1063

Query: 342  AGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESA 401
                E+   + Q L   H++L +   ++EA       +++  + R +D   ++R  LE A
Sbjct: 1064 Q---EETRGQQQALLRDHKALAQLQRRQEA-------ELEGLLVRHRDLKANMRA-LELA 1112

Query: 402  NRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRR------RA 455
            +R L  + ++ QA      A + AQ      E+E+L ++    RG  E+ RR      RA
Sbjct: 1113 HRELQGRHEQLQAQR----ASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRA 1168

Query: 456  ELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLEL---RLRT 512
            ++L   L   +G       ELR + A +E +ER Q  + Q Q   E  +QL+L   RL T
Sbjct: 1169 QMLLAELSRERGELQGERGELRGRLARLE-LERAQLEM-QSQQLRESNQQLDLSACRLTT 1226

Query: 513  RLE--QELKALRAQQRQAGAPGGSSGSGGSPEL------SALRLSEQLREKEEQILALEA 564
            + E   +L++ + ++ +       + S  + EL      S   L  + RE  +Q+ AL  
Sbjct: 1227 QCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRR 1286

Query: 565  DMTKWEQKYLEE 576
            +  K  +K +++
Sbjct: 1287 EKQKLVEKIMDQ 1298



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 81/311 (26%), Positives = 131/311 (42%), Gaps = 58/311 (18%)

Query: 305  TSGSAHLAQMEAVLRENARLQRDNER--------------LQRELESSA-EKAGRIEKLE 349
            + G  HL + E   RE   LQ + E+              LQRELE +A E+   + + E
Sbjct: 851  SEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKE 910

Query: 350  SEIQRLSEAHESL-----TRASSKREALE--KTMRNKMDSEMRRLQDFNRDLRERLESAN 402
            S+ QR     + L       A+SK EAL   KT   +++ E+ +L+     L  + + A 
Sbjct: 911  SQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPK-KRAE 969

Query: 403  RRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQAL 462
             +L           +   A L+A+    Q + + LE ++  L+G      R  ELL Q+ 
Sbjct: 970  PQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQG------RAQELLLQSQ 1023

Query: 463  GNAQGRAARAE----------EELRKKQAYVEKVERL-----QQALGQLQAACEKREQLE 507
              AQ  ++R +          +EL +K   +E+  R      ++  GQ QA     + L 
Sbjct: 1024 -RAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKAL- 1081

Query: 508  LRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLS-EQLREKEEQILALEADM 566
             +L+ R E EL+ L  + R   A            + AL L+  +L+ + EQ+ A  A +
Sbjct: 1082 AQLQRRQEAELEGLLVRHRDLKA-----------NMRALELAHRELQGRHEQLQAQRASV 1130

Query: 567  TKWEQKYLEER 577
               E   L ER
Sbjct: 1131 EAQEVALLAER 1141



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 69/310 (22%), Positives = 119/310 (38%), Gaps = 36/310 (11%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREA 371
            AQ  A+L E  RL +D  R QR LE        + +L+SE  R       L+R   + + 
Sbjct: 1132 AQEVALLAERERLMQDGHR-QRGLEEE------LRRLQSEHDRAQMLLAELSRERGELQG 1184

Query: 372  LEKTMRN---KMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSY 428
                +R    +++ E  +L+  ++ LRE  +  +      T + +  +Q        +S 
Sbjct: 1185 ERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQ-------LRSA 1237

Query: 429  EQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVER 488
            ++++ ++ L    AL        R   ELLE++L +         E L +  A   + ++
Sbjct: 1238 QEEENRQLLAEVQAL-------SRENRELLERSLESRDHLHREQREYLDQLNALRREKQK 1290

Query: 489  LQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPG----GSSGSGGSPELS 544
            L + +       E       +  + L  ++K L   +R+ G PG    G+ G+G +  L 
Sbjct: 1291 LVEKIMDQYRVLEPVPLPRTKKGSWLADKVKRLMRPRREGGPPGGLRLGADGAGSTESLG 1350

Query: 545  ALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQ 604
                +E    +       EAD T         RA     +     A  QR   L    P 
Sbjct: 1351 GPPETELPEGR-------EADGTGSPSPAPMRRAQSSLCLRDETLAGGQR-RKLSSRFPV 1402

Query: 605  PSPSSSFNEG 614
               S SF+ G
Sbjct: 1403 GRSSESFSPG 1412



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 113/513 (22%), Positives = 185/513 (36%), Gaps = 85/513 (16%)

Query: 241 HAEVRILQAQVPPVFLQQQQQYQYLQQSQEHPPPPHPAALGHGPLSSLSPPAVEGPVSAQ 300
           HAE+  L+ QV  +  +  +    LQ+S E PPP  P   G  PL+  +P   +    A+
Sbjct: 402 HAELDSLRHQVDQLAEENVELELELQRSLE-PPPGSP---GEAPLAGAAPSLQDEVREAE 457

Query: 301 ASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESE-----IQRL 355
           A           ++  + REN  L+   + LQ       +  G+   LE+      +  L
Sbjct: 458 AG----------RLRTLERENRELRGLLQVLQ------GQPGGQHPLLEAPREDPVLPVL 501

Query: 356 SEAHESLTRASSKREALEKTMRN-----------KMDSEMRRLQDFNRDLRERLESANRR 404
            EA ++        + L +  R+            +DS +    +  +      + A   
Sbjct: 502 EEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESP 561

Query: 405 LASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMAL--------------------- 443
           L +   + QA   D   +      E Q+  EK  R  +L                     
Sbjct: 562 LQAAAMDPQAS--DWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQL 619

Query: 444 LRGAIEDQRR-RAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEK 502
           L G  E +   + EL+ +A G  Q                +E+ E   Q L       E 
Sbjct: 620 LGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEA 679

Query: 503 RE---QLELRLRTRLEQELK-----ALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLRE 554
           RE   +LE  +R    Q+ +     AL  Q  +   PG S  SG + + +      QLR 
Sbjct: 680 REHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRR 739

Query: 555 KEEQIL-ALEADMTKWEQKYLEE-RAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFN 612
           K E +   LEA   K E +  E  R  ++ A    A A A R+        Q    +   
Sbjct: 740 KAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREA-----EAQAWEQARLR 794

Query: 613 EGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQGSLRPAKSVPSVF 672
           E +   G   QE+ES  +       E++A+++ L    R       +GS   A+S  +  
Sbjct: 795 EAVEAAG---QELESASQ-------EREALVEALAAAGRERRQWEREGSRLRAQSEAAEE 844

Query: 673 AAAAAGTQGWQGLSSSERQTADAPARLTTADRA 705
                 ++G Q L  +ER+  +  A     ++A
Sbjct: 845 RMQVLESEGRQHLEEAERERREKEALQAELEKA 877



 Score = 35.0 bits (79), Expect = 0.27
 Identities = 53/240 (22%), Positives = 96/240 (40%), Gaps = 56/240 (23%)

Query: 294 EGPVSAQASSATSGSAHLAQMEAVLRENARLQRDN------------------------- 328
           EGP    A    +  A L ++   L E A L  D+                         
Sbjct: 250 EGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQA 309

Query: 329 ---ERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMR 385
              E  + E E+  E+AGR+ +L+ E++R  E  ++     S+ E  E+ +   +++   
Sbjct: 310 KRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEE-ERVLSGVLEASKA 368

Query: 386 RLQDFNRDLRERL----ESANRRLASKTQEAQAGSQ-DMVAKLLAQSYEQQQEQE-KLER 439
            L++     RER     E+    L  +T+  +A ++ D +   + Q  E+  E E +L+R
Sbjct: 369 LLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQR 428

Query: 440 EM---------ALLRGA---IEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVE 487
            +         A L GA   ++D+ R AE          GR    E E R+ +  ++ ++
Sbjct: 429 SLEPPPGSPGEAPLAGAAPSLQDEVREAE---------AGRLRTLERENRELRGLLQVLQ 479


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 80/375 (21%), Positives = 153/375 (40%), Gaps = 36/375 (9%)

Query: 298  SAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRE--LESSAEKAGR-----IEKLES 350
            +A A +   G A    ++++    A L    E L+ E    + AEK  R     +E L  
Sbjct: 1119 AALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRG 1178

Query: 351  EIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQ 410
            E++   ++  +     SKRE     ++  ++ E R  +   ++LR+R   A   LA + +
Sbjct: 1179 ELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLE 1238

Query: 411  EAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAA 470
            +A+ G        LA     + E  +L  E++ L+ A ++  +R   LE  L   QGRA 
Sbjct: 1239 QARRGKGAWEKTRLA----LEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAG 1294

Query: 471  RAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLE------QELKALRAQ 524
              E   R +    EK++R Q  L  +  A  + E   +RL   L        + + L  +
Sbjct: 1295 DGE---RARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQE 1351

Query: 525  QRQAGAPGGSSGSGGSPELSALRLSEQLREKE-------EQILALEADMTKWEQKYLEER 577
            + +A    GS       E + LR  EQL E+         ++   +A +++W ++  EE 
Sbjct: 1352 ETRAKLALGSRVRAMEAEAAGLR--EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEA 1409

Query: 578  AMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQIL 637
               +   +A   AA + +    R + +         G        + ++  L      + 
Sbjct: 1410 GALEAGEEARRRAAREAEALTQRLAEKTETVDRLERG-------RRRLQQELDDATMDLE 1462

Query: 638  EKDAVIKVLQQRSRR 652
            ++  ++  L+++ R+
Sbjct: 1463 QQRQLVSTLEKKQRK 1477



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 114/464 (24%), Positives = 186/464 (40%), Gaps = 96/464 (20%)

Query: 292  AVEGPVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRE-------LESSAEKAGR 344
            A+E    A+  +A    A   ++        RL+R   RLQ+E       LE   +    
Sbjct: 1411 ALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVST 1470

Query: 345  IEKLESEI-QRLSEAHESLTRASSKREALEKTMRNK--MDSEMRRLQDFNRDLRERLESA 401
            +EK + +  Q L+E   ++ RA  +RE  E   R +      + R  +  ++ RE LE  
Sbjct: 1471 LEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQ 1530

Query: 402  NRRLASKTQEAQAGSQDMVAKLLAQ-----------SYEQQQEQEKLEREMALLRGAIED 450
            NR L ++  EA   S+D V K + +           + + + +  +LE E+     A ED
Sbjct: 1531 NRALRAEL-EALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELT----AAED 1585

Query: 451  QRRRAELLEQAL-----GNAQGRAARAEEELRK--KQAYVEKVERLQQALGQLQAACEKR 503
             + R E+  QAL      + QGR    EE  R+  KQ    +VER ++          K+
Sbjct: 1586 AKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE---------RKQ 1636

Query: 504  EQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALR---------------- 547
              L +  R +LE EL+ L+AQ         S+G G    +  LR                
Sbjct: 1637 RTLAVAARKKLEGELEELKAQM-------ASAGQGKEEAVKQLRKMQAQMKELWREVEET 1689

Query: 548  ------LSEQLREKEEQILALEADMTKWEQKY-LEERAMRQFAMDAAATAAAQRDTTLIR 600
                  +  Q RE E+++  LEA++ + +++    +RA RQ   D    A    +  L  
Sbjct: 1690 RTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNL-- 1747

Query: 601  HSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQ- 659
                 S ++   E         +++E RL  L  ++ E+ +  ++L  R R+     +Q 
Sbjct: 1748 -----SKAAILEE--------KRQLEGRLGQLEEELEEEQSNSELLNDRYRK---LLLQV 1791

Query: 660  GSLRPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPARLTTAD 703
             SL    S    F+A A       G    ERQ  +   RL   D
Sbjct: 1792 ESLTTELSAERSFSAKAE-----SGRQQLERQIQELRGRLGEED 1830



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 80/380 (21%), Positives = 154/380 (40%), Gaps = 67/380 (17%)

Query: 311  LAQMEAVLRENAR-LQRDNERLQRELESSAEKAGRIEKLESEIQRLSE-----------A 358
            + + + VL+  A+ LQ+  E  Q+      E  GR+ +LE E  RL+E           A
Sbjct: 872  VTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEA 931

Query: 359  HESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQA---G 415
             E+  R +++++ LE  +     SE+        +   ++++  +RL    QE +A    
Sbjct: 932  EETRGRLAARKQELELVV-----SELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEA 986

Query: 416  SQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEE 475
             +    KL  +    + + +K E ++ LL        +  +LLE  L     +AA  EE+
Sbjct: 987  EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEK 1046

Query: 476  ---------------------LRKKQAYVEKVERLQQAL----GQLQAACEKREQLELRL 510
                                 LRK++   +++E+L++ L     +LQ    +++Q    L
Sbjct: 1047 VKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEEL 1106

Query: 511  RTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADM-TKW 569
            R +L ++ + L+A   +A   GG+            +L + LRE +  +   + D+ ++ 
Sbjct: 1107 RAQLGRKEEELQAALARAEDEGGARA----------QLLKSLREAQAALAEAQEDLESER 1156

Query: 570  EQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESRL 629
              +   E+  R    +  A      DT    ++ Q   S            R QE+    
Sbjct: 1157 VARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSK-----------REQEVTELK 1205

Query: 630  KVLHAQILEKDAVIKVLQQR 649
            K L  +    +A ++ L+QR
Sbjct: 1206 KTLEEETRIHEAAVQELRQR 1225



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 92/442 (20%), Positives = 162/442 (36%), Gaps = 119/442 (26%)

Query: 320  ENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHES--------LTRASSKREA 371
            +N++L ++ + L+  L   + +A   E+    + +L   +E+        L +    R+ 
Sbjct: 1018 QNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE 1077

Query: 372  LEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQA----------------- 414
            LEK ++ ++D E   LQ+   + ++R E    +L  K +E QA                 
Sbjct: 1078 LEK-LKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLK 1136

Query: 415  -----------GSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIED------------Q 451
                         +D+ ++ +A++  ++Q ++ L  E+  LRG +ED             
Sbjct: 1137 SLREAQAALAEAQEDLESERVARTKAEKQRRD-LGEELEALRGELEDTLDSTNAQQELRS 1195

Query: 452  RRRAEL--------------------LEQALGNAQGRAARAEEELRKKQAYVEK------ 485
            +R  E+                    L Q  G A G  A   E+ R+ +   EK      
Sbjct: 1196 KREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1255

Query: 486  --VERLQQALGQLQAACEKREQLELRLRTRLEQ-----------ELKALRAQQRQAGAPG 532
              V  L+  L  LQ A ++ EQ   RL  +L++             +A    QR      
Sbjct: 1256 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1315

Query: 533  GSSGSGGSPELSALRLSEQLREKEEQ---------------------ILALEADMTKWEQ 571
              SG+    E   +RLS++L   E Q                     + A+EA+     +
Sbjct: 1316 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLRE 1375

Query: 572  KYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESR-LK 630
            +  EE A R+ A     TA AQ      R   +         G L  G   +   +R  +
Sbjct: 1376 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEE--------AGALEAGEEARRRAAREAE 1427

Query: 631  VLHAQILEKDAVIKVLQQRSRR 652
             L  ++ EK   +  L++  RR
Sbjct: 1428 ALTQRLAEKTETVDRLERGRRR 1449



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 93/382 (24%), Positives = 155/382 (40%), Gaps = 67/382 (17%)

Query: 299  AQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESS-AEKAGRIEKLESEIQRLSE 357
            A  S   +  A  A +   L E A  +   ER  REL+++ A+ +    + E E   L  
Sbjct: 1358 ALGSRVRAMEAEAAGLREQLEEEAAAR---ERAGRELQTAQAQLSEWRRRQEEEAGALEA 1414

Query: 358  AHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQ 417
              E+  RA+ + EAL + +  K ++             +RLE   RRL  +  +A    +
Sbjct: 1415 GEEARRRAAREAEALTQRLAEKTETV------------DRLERGRRRLQQELDDATMDLE 1462

Query: 418  DMVAKLLAQSYEQQQ---EQEKLEREMALLRGAIEDQRRRAELLE-QALGNAQGRAARAE 473
                + L  + E++Q   +Q   E + A+LR   E +R  AE  E +A   +  RA   E
Sbjct: 1463 QQ--RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEE 1520

Query: 474  EELRKK------------QAYVEKVERLQQALGQLQAACEKREQLELRLR---TRLEQEL 518
            +E R++            +A +   + + +++ +L+ AC   EQ    LR   T LE EL
Sbjct: 1521 QEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1580

Query: 519  KA---------LRAQQRQAGAPGGSSGSGGSPELSALRLSEQLR--------EKEEQILA 561
             A         +  Q  +        G   + E    +L++QLR        E++++ LA
Sbjct: 1581 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLA 1640

Query: 562  LEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHR 621
            + A      +K LE       A  A+A    +     +R   Q      + E   T   R
Sbjct: 1641 VAA------RKKLEGELEELKAQMASAGQGKEEAVKQLR-KMQAQMKELWREVEETRTSR 1693

Query: 622  ------HQEMESRLKVLHAQIL 637
                  ++E E RLK L A++L
Sbjct: 1694 EEIFSQNRESEKRLKGLEAEVL 1715



 Score = 30.4 bits (67), Expect = 6.6
 Identities = 28/119 (23%), Positives = 49/119 (41%), Gaps = 19/119 (15%)

Query: 315  EAVLRENARLQRDNERLQRELESSAEKAG-RIEKLESEIQRLSEAHESLTRASSKREALE 373
            E  L+E      +  R+  +L    EK   R+++L+   ++L EA E  +RA + R    
Sbjct: 1873 EKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLK---RQLEEAEEEASRAQAGR---- 1925

Query: 374  KTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQ 432
                       RRLQ    D+ E  ES NR + +     + G      + + Q +  ++
Sbjct: 1926 -----------RRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEE 1973


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 80/375 (21%), Positives = 153/375 (40%), Gaps = 36/375 (9%)

Query: 298  SAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRE--LESSAEKAGR-----IEKLES 350
            +A A +   G A    ++++    A L    E L+ E    + AEK  R     +E L  
Sbjct: 1111 AALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRG 1170

Query: 351  EIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQ 410
            E++   ++  +     SKRE     ++  ++ E R  +   ++LR+R   A   LA + +
Sbjct: 1171 ELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLE 1230

Query: 411  EAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAA 470
            +A+ G        LA     + E  +L  E++ L+ A ++  +R   LE  L   QGRA 
Sbjct: 1231 QARRGKGAWEKTRLA----LEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAG 1286

Query: 471  RAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLE------QELKALRAQ 524
              E   R +    EK++R Q  L  +  A  + E   +RL   L        + + L  +
Sbjct: 1287 DGE---RARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQE 1343

Query: 525  QRQAGAPGGSSGSGGSPELSALRLSEQLREKE-------EQILALEADMTKWEQKYLEER 577
            + +A    GS       E + LR  EQL E+         ++   +A +++W ++  EE 
Sbjct: 1344 ETRAKLALGSRVRAMEAEAAGLR--EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEA 1401

Query: 578  AMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQIL 637
               +   +A   AA + +    R + +         G        + ++  L      + 
Sbjct: 1402 GALEAGEEARRRAAREAEALTQRLAEKTETVDRLERG-------RRRLQQELDDATMDLE 1454

Query: 638  EKDAVIKVLQQRSRR 652
            ++  ++  L+++ R+
Sbjct: 1455 QQRQLVSTLEKKQRK 1469



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 114/464 (24%), Positives = 186/464 (40%), Gaps = 96/464 (20%)

Query: 292  AVEGPVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRE-------LESSAEKAGR 344
            A+E    A+  +A    A   ++        RL+R   RLQ+E       LE   +    
Sbjct: 1403 ALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVST 1462

Query: 345  IEKLESEI-QRLSEAHESLTRASSKREALEKTMRNK--MDSEMRRLQDFNRDLRERLESA 401
            +EK + +  Q L+E   ++ RA  +RE  E   R +      + R  +  ++ RE LE  
Sbjct: 1463 LEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQ 1522

Query: 402  NRRLASKTQEAQAGSQDMVAKLLAQ-----------SYEQQQEQEKLEREMALLRGAIED 450
            NR L ++  EA   S+D V K + +           + + + +  +LE E+     A ED
Sbjct: 1523 NRALRAEL-EALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELT----AAED 1577

Query: 451  QRRRAELLEQAL-----GNAQGRAARAEEELRK--KQAYVEKVERLQQALGQLQAACEKR 503
             + R E+  QAL      + QGR    EE  R+  KQ    +VER ++          K+
Sbjct: 1578 AKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE---------RKQ 1628

Query: 504  EQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALR---------------- 547
              L +  R +LE EL+ L+AQ         S+G G    +  LR                
Sbjct: 1629 RTLAVAARKKLEGELEELKAQM-------ASAGQGKEEAVKQLRKMQAQMKELWREVEET 1681

Query: 548  ------LSEQLREKEEQILALEADMTKWEQKY-LEERAMRQFAMDAAATAAAQRDTTLIR 600
                  +  Q RE E+++  LEA++ + +++    +RA RQ   D    A    +  L  
Sbjct: 1682 RTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNL-- 1739

Query: 601  HSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQ- 659
                 S ++   E         +++E RL  L  ++ E+ +  ++L  R R+     +Q 
Sbjct: 1740 -----SKAAILEE--------KRQLEGRLGQLEEELEEEQSNSELLNDRYRK---LLLQV 1783

Query: 660  GSLRPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPARLTTAD 703
             SL    S    F+A A       G    ERQ  +   RL   D
Sbjct: 1784 ESLTTELSAERSFSAKAE-----SGRQQLERQIQELRGRLGEED 1822



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 80/380 (21%), Positives = 154/380 (40%), Gaps = 67/380 (17%)

Query: 311  LAQMEAVLRENAR-LQRDNERLQRELESSAEKAGRIEKLESEIQRLSE-----------A 358
            + + + VL+  A+ LQ+  E  Q+      E  GR+ +LE E  RL+E           A
Sbjct: 864  VTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEA 923

Query: 359  HESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQA---G 415
             E+  R +++++ LE  +     SE+        +   ++++  +RL    QE +A    
Sbjct: 924  EETRGRLAARKQELELVV-----SELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEA 978

Query: 416  SQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEE 475
             +    KL  +    + + +K E ++ LL        +  +LLE  L     +AA  EE+
Sbjct: 979  EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEK 1038

Query: 476  ---------------------LRKKQAYVEKVERLQQAL----GQLQAACEKREQLELRL 510
                                 LRK++   +++E+L++ L     +LQ    +++Q    L
Sbjct: 1039 VKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEEL 1098

Query: 511  RTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADM-TKW 569
            R +L ++ + L+A   +A   GG+            +L + LRE +  +   + D+ ++ 
Sbjct: 1099 RAQLGRKEEELQAALARAEDEGGARA----------QLLKSLREAQAALAEAQEDLESER 1148

Query: 570  EQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESRL 629
              +   E+  R    +  A      DT    ++ Q   S            R QE+    
Sbjct: 1149 VARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSK-----------REQEVTELK 1197

Query: 630  KVLHAQILEKDAVIKVLQQR 649
            K L  +    +A ++ L+QR
Sbjct: 1198 KTLEEETRIHEAAVQELRQR 1217



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 92/442 (20%), Positives = 162/442 (36%), Gaps = 119/442 (26%)

Query: 320  ENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHES--------LTRASSKREA 371
            +N++L ++ + L+  L   + +A   E+    + +L   +E+        L +    R+ 
Sbjct: 1010 QNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE 1069

Query: 372  LEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQA----------------- 414
            LEK ++ ++D E   LQ+   + ++R E    +L  K +E QA                 
Sbjct: 1070 LEK-LKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLK 1128

Query: 415  -----------GSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIED------------Q 451
                         +D+ ++ +A++  ++Q ++ L  E+  LRG +ED             
Sbjct: 1129 SLREAQAALAEAQEDLESERVARTKAEKQRRD-LGEELEALRGELEDTLDSTNAQQELRS 1187

Query: 452  RRRAEL--------------------LEQALGNAQGRAARAEEELRKKQAYVEK------ 485
            +R  E+                    L Q  G A G  A   E+ R+ +   EK      
Sbjct: 1188 KREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1247

Query: 486  --VERLQQALGQLQAACEKREQLELRLRTRLEQ-----------ELKALRAQQRQAGAPG 532
              V  L+  L  LQ A ++ EQ   RL  +L++             +A    QR      
Sbjct: 1248 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1307

Query: 533  GSSGSGGSPELSALRLSEQLREKEEQ---------------------ILALEADMTKWEQ 571
              SG+    E   +RLS++L   E Q                     + A+EA+     +
Sbjct: 1308 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLRE 1367

Query: 572  KYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESR-LK 630
            +  EE A R+ A     TA AQ      R   +         G L  G   +   +R  +
Sbjct: 1368 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEE--------AGALEAGEEARRRAAREAE 1419

Query: 631  VLHAQILEKDAVIKVLQQRSRR 652
             L  ++ EK   +  L++  RR
Sbjct: 1420 ALTQRLAEKTETVDRLERGRRR 1441



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 93/382 (24%), Positives = 155/382 (40%), Gaps = 67/382 (17%)

Query: 299  AQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESS-AEKAGRIEKLESEIQRLSE 357
            A  S   +  A  A +   L E A  +   ER  REL+++ A+ +    + E E   L  
Sbjct: 1350 ALGSRVRAMEAEAAGLREQLEEEAAAR---ERAGRELQTAQAQLSEWRRRQEEEAGALEA 1406

Query: 358  AHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQ 417
              E+  RA+ + EAL + +  K ++             +RLE   RRL  +  +A    +
Sbjct: 1407 GEEARRRAAREAEALTQRLAEKTETV------------DRLERGRRRLQQELDDATMDLE 1454

Query: 418  DMVAKLLAQSYEQQQ---EQEKLEREMALLRGAIEDQRRRAELLE-QALGNAQGRAARAE 473
                + L  + E++Q   +Q   E + A+LR   E +R  AE  E +A   +  RA   E
Sbjct: 1455 QQ--RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEE 1512

Query: 474  EELRKK------------QAYVEKVERLQQALGQLQAACEKREQLELRLR---TRLEQEL 518
            +E R++            +A +   + + +++ +L+ AC   EQ    LR   T LE EL
Sbjct: 1513 QEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1572

Query: 519  KA---------LRAQQRQAGAPGGSSGSGGSPELSALRLSEQLR--------EKEEQILA 561
             A         +  Q  +        G   + E    +L++QLR        E++++ LA
Sbjct: 1573 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLA 1632

Query: 562  LEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHR 621
            + A      +K LE       A  A+A    +     +R   Q      + E   T   R
Sbjct: 1633 VAA------RKKLEGELEELKAQMASAGQGKEEAVKQLR-KMQAQMKELWREVEETRTSR 1685

Query: 622  ------HQEMESRLKVLHAQIL 637
                  ++E E RLK L A++L
Sbjct: 1686 EEIFSQNRESEKRLKGLEAEVL 1707



 Score = 30.4 bits (67), Expect = 6.6
 Identities = 28/119 (23%), Positives = 49/119 (41%), Gaps = 19/119 (15%)

Query: 315  EAVLRENARLQRDNERLQRELESSAEKAG-RIEKLESEIQRLSEAHESLTRASSKREALE 373
            E  L+E      +  R+  +L    EK   R+++L+   ++L EA E  +RA + R    
Sbjct: 1865 EKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLK---RQLEEAEEEASRAQAGR---- 1917

Query: 374  KTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQ 432
                       RRLQ    D+ E  ES NR + +     + G      + + Q +  ++
Sbjct: 1918 -----------RRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEE 1965


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 80/375 (21%), Positives = 153/375 (40%), Gaps = 36/375 (9%)

Query: 298  SAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRE--LESSAEKAGR-----IEKLES 350
            +A A +   G A    ++++    A L    E L+ E    + AEK  R     +E L  
Sbjct: 1152 AALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRG 1211

Query: 351  EIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQ 410
            E++   ++  +     SKRE     ++  ++ E R  +   ++LR+R   A   LA + +
Sbjct: 1212 ELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLE 1271

Query: 411  EAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAA 470
            +A+ G        LA     + E  +L  E++ L+ A ++  +R   LE  L   QGRA 
Sbjct: 1272 QARRGKGAWEKTRLA----LEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAG 1327

Query: 471  RAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLE------QELKALRAQ 524
              E   R +    EK++R Q  L  +  A  + E   +RL   L        + + L  +
Sbjct: 1328 DGE---RARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQE 1384

Query: 525  QRQAGAPGGSSGSGGSPELSALRLSEQLREKE-------EQILALEADMTKWEQKYLEER 577
            + +A    GS       E + LR  EQL E+         ++   +A +++W ++  EE 
Sbjct: 1385 ETRAKLALGSRVRAMEAEAAGLR--EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEA 1442

Query: 578  AMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQIL 637
               +   +A   AA + +    R + +         G        + ++  L      + 
Sbjct: 1443 GALEAGEEARRRAAREAEALTQRLAEKTETVDRLERG-------RRRLQQELDDATMDLE 1495

Query: 638  EKDAVIKVLQQRSRR 652
            ++  ++  L+++ R+
Sbjct: 1496 QQRQLVSTLEKKQRK 1510



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 114/464 (24%), Positives = 186/464 (40%), Gaps = 96/464 (20%)

Query: 292  AVEGPVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRE-------LESSAEKAGR 344
            A+E    A+  +A    A   ++        RL+R   RLQ+E       LE   +    
Sbjct: 1444 ALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVST 1503

Query: 345  IEKLESEI-QRLSEAHESLTRASSKREALEKTMRNK--MDSEMRRLQDFNRDLRERLESA 401
            +EK + +  Q L+E   ++ RA  +RE  E   R +      + R  +  ++ RE LE  
Sbjct: 1504 LEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQ 1563

Query: 402  NRRLASKTQEAQAGSQDMVAKLLAQ-----------SYEQQQEQEKLEREMALLRGAIED 450
            NR L ++  EA   S+D V K + +           + + + +  +LE E+     A ED
Sbjct: 1564 NRALRAEL-EALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELT----AAED 1618

Query: 451  QRRRAELLEQAL-----GNAQGRAARAEEELRK--KQAYVEKVERLQQALGQLQAACEKR 503
             + R E+  QAL      + QGR    EE  R+  KQ    +VER ++          K+
Sbjct: 1619 AKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE---------RKQ 1669

Query: 504  EQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALR---------------- 547
              L +  R +LE EL+ L+AQ         S+G G    +  LR                
Sbjct: 1670 RTLAVAARKKLEGELEELKAQM-------ASAGQGKEEAVKQLRKMQAQMKELWREVEET 1722

Query: 548  ------LSEQLREKEEQILALEADMTKWEQKY-LEERAMRQFAMDAAATAAAQRDTTLIR 600
                  +  Q RE E+++  LEA++ + +++    +RA RQ   D    A    +  L  
Sbjct: 1723 RTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNL-- 1780

Query: 601  HSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQ- 659
                 S ++   E         +++E RL  L  ++ E+ +  ++L  R R+     +Q 
Sbjct: 1781 -----SKAAILEE--------KRQLEGRLGQLEEELEEEQSNSELLNDRYRK---LLLQV 1824

Query: 660  GSLRPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPARLTTAD 703
             SL    S    F+A A       G    ERQ  +   RL   D
Sbjct: 1825 ESLTTELSAERSFSAKAE-----SGRQQLERQIQELRGRLGEED 1863



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 80/380 (21%), Positives = 154/380 (40%), Gaps = 67/380 (17%)

Query: 311  LAQMEAVLRENAR-LQRDNERLQRELESSAEKAGRIEKLESEIQRLSE-----------A 358
            + + + VL+  A+ LQ+  E  Q+      E  GR+ +LE E  RL+E           A
Sbjct: 905  VTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEA 964

Query: 359  HESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQA---G 415
             E+  R +++++ LE  +     SE+        +   ++++  +RL    QE +A    
Sbjct: 965  EETRGRLAARKQELELVV-----SELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEA 1019

Query: 416  SQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEE 475
             +    KL  +    + + +K E ++ LL        +  +LLE  L     +AA  EE+
Sbjct: 1020 EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEK 1079

Query: 476  ---------------------LRKKQAYVEKVERLQQAL----GQLQAACEKREQLELRL 510
                                 LRK++   +++E+L++ L     +LQ    +++Q    L
Sbjct: 1080 VKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEEL 1139

Query: 511  RTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADM-TKW 569
            R +L ++ + L+A   +A   GG+            +L + LRE +  +   + D+ ++ 
Sbjct: 1140 RAQLGRKEEELQAALARAEDEGGARA----------QLLKSLREAQAALAEAQEDLESER 1189

Query: 570  EQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESRL 629
              +   E+  R    +  A      DT    ++ Q   S            R QE+    
Sbjct: 1190 VARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSK-----------REQEVTELK 1238

Query: 630  KVLHAQILEKDAVIKVLQQR 649
            K L  +    +A ++ L+QR
Sbjct: 1239 KTLEEETRIHEAAVQELRQR 1258



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 92/442 (20%), Positives = 162/442 (36%), Gaps = 119/442 (26%)

Query: 320  ENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHES--------LTRASSKREA 371
            +N++L ++ + L+  L   + +A   E+    + +L   +E+        L +    R+ 
Sbjct: 1051 QNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE 1110

Query: 372  LEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQA----------------- 414
            LEK ++ ++D E   LQ+   + ++R E    +L  K +E QA                 
Sbjct: 1111 LEK-LKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLK 1169

Query: 415  -----------GSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIED------------Q 451
                         +D+ ++ +A++  ++Q ++ L  E+  LRG +ED             
Sbjct: 1170 SLREAQAALAEAQEDLESERVARTKAEKQRRD-LGEELEALRGELEDTLDSTNAQQELRS 1228

Query: 452  RRRAEL--------------------LEQALGNAQGRAARAEEELRKKQAYVEK------ 485
            +R  E+                    L Q  G A G  A   E+ R+ +   EK      
Sbjct: 1229 KREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1288

Query: 486  --VERLQQALGQLQAACEKREQLELRLRTRLEQ-----------ELKALRAQQRQAGAPG 532
              V  L+  L  LQ A ++ EQ   RL  +L++             +A    QR      
Sbjct: 1289 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1348

Query: 533  GSSGSGGSPELSALRLSEQLREKEEQ---------------------ILALEADMTKWEQ 571
              SG+    E   +RLS++L   E Q                     + A+EA+     +
Sbjct: 1349 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLRE 1408

Query: 572  KYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESR-LK 630
            +  EE A R+ A     TA AQ      R   +         G L  G   +   +R  +
Sbjct: 1409 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEE--------AGALEAGEEARRRAAREAE 1460

Query: 631  VLHAQILEKDAVIKVLQQRSRR 652
             L  ++ EK   +  L++  RR
Sbjct: 1461 ALTQRLAEKTETVDRLERGRRR 1482



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 93/382 (24%), Positives = 155/382 (40%), Gaps = 67/382 (17%)

Query: 299  AQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESS-AEKAGRIEKLESEIQRLSE 357
            A  S   +  A  A +   L E A  +   ER  REL+++ A+ +    + E E   L  
Sbjct: 1391 ALGSRVRAMEAEAAGLREQLEEEAAAR---ERAGRELQTAQAQLSEWRRRQEEEAGALEA 1447

Query: 358  AHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQ 417
              E+  RA+ + EAL + +  K ++             +RLE   RRL  +  +A    +
Sbjct: 1448 GEEARRRAAREAEALTQRLAEKTETV------------DRLERGRRRLQQELDDATMDLE 1495

Query: 418  DMVAKLLAQSYEQQQ---EQEKLEREMALLRGAIEDQRRRAELLE-QALGNAQGRAARAE 473
                + L  + E++Q   +Q   E + A+LR   E +R  AE  E +A   +  RA   E
Sbjct: 1496 QQ--RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEE 1553

Query: 474  EELRKK------------QAYVEKVERLQQALGQLQAACEKREQLELRLR---TRLEQEL 518
            +E R++            +A +   + + +++ +L+ AC   EQ    LR   T LE EL
Sbjct: 1554 QEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1613

Query: 519  KA---------LRAQQRQAGAPGGSSGSGGSPELSALRLSEQLR--------EKEEQILA 561
             A         +  Q  +        G   + E    +L++QLR        E++++ LA
Sbjct: 1614 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLA 1673

Query: 562  LEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHR 621
            + A      +K LE       A  A+A    +     +R   Q      + E   T   R
Sbjct: 1674 VAA------RKKLEGELEELKAQMASAGQGKEEAVKQLR-KMQAQMKELWREVEETRTSR 1726

Query: 622  ------HQEMESRLKVLHAQIL 637
                  ++E E RLK L A++L
Sbjct: 1727 EEIFSQNRESEKRLKGLEAEVL 1748



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 87/413 (21%), Positives = 156/413 (37%), Gaps = 100/413 (24%)

Query: 274  PPHPAALGHGPLSSLSPPAVEGPVS-AQASSATSG------------SAHLAQMEAVLRE 320
            PP P        S++SPP VEG V   Q SS   G            +      E++ R 
Sbjct: 663  PPSPPGSAERCSSAISPPGVEGIVGLEQVSSLGDGPPGGRPRRGMFRTVGQLYKESLSRL 722

Query: 321  NARLQRDNERLQRELESSAEK-AGRIEK------------LES------------EIQRL 355
             A L   N    R +  + EK AG++E             LE               Q  
Sbjct: 723  MATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEF 782

Query: 356  SEAHESLTRAS------SKREALEKTMRN-KMDSEMRRLQD----FNRDLRERL-ESANR 403
             + +E LT  +        ++A EK ++  ++D  + R+      F   +  +L E  + 
Sbjct: 783  RQRYEILTPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDL 842

Query: 404  RLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEK--------------------------- 436
            ++       QA ++  +A+   Q  +QQQ   +                           
Sbjct: 843  KVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPL 902

Query: 437  --LEREMALLRGAIEDQRRRAELLEQA---LGNAQGRAARAEEE----LRKKQAYVEKVE 487
              + R+  +L+   ++ ++  EL +Q+   +G  QGR A+ EEE      + +A  E   
Sbjct: 903  LQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCA 962

Query: 488  RLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQ-----------AGAPGGSSG 536
              ++  G+L A  ++ E +   L  R+ +E +  R  Q +                   G
Sbjct: 963  EAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 1022

Query: 537  SGGSPELSALRLSEQLREKEEQILALEADMTKW--EQKYLEERAMRQFAMDAA 587
            +    +L  +    ++++ EE +L LE   +K   E+K LE+R + +F+  AA
Sbjct: 1023 ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDR-LAEFSSQAA 1074



 Score = 30.4 bits (67), Expect = 6.6
 Identities = 28/119 (23%), Positives = 49/119 (41%), Gaps = 19/119 (15%)

Query: 315  EAVLRENARLQRDNERLQRELESSAEKAG-RIEKLESEIQRLSEAHESLTRASSKREALE 373
            E  L+E      +  R+  +L    EK   R+++L+   ++L EA E  +RA + R    
Sbjct: 1906 EKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLK---RQLEEAEEEASRAQAGR---- 1958

Query: 374  KTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQ 432
                       RRLQ    D+ E  ES NR + +     + G      + + Q +  ++
Sbjct: 1959 -----------RRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEE 2006


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 69/279 (24%), Positives = 126/279 (45%), Gaps = 30/279 (10%)

Query: 315 EAVLR-ENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALE 373
           E VLR E  +LQ +  + QREL+   E+  ++E+ E   +R  E  +       +R   E
Sbjct: 250 ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQ------QRLRRE 303

Query: 374 KTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKL------LAQS 427
           + +R K + E R  Q+  R+ +ER E    R   + +  Q   ++   +         Q 
Sbjct: 304 QQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQ 363

Query: 428 YEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVE 487
             ++QE+E+ E+++       E Q RR + L +     + +  R E++LR++Q    ++ 
Sbjct: 364 LRREQEEERREQQLRR-----EQQLRREQQLRREQQLRREQQLRREQQLRREQ----QLR 414

Query: 488 RLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALR 547
           R QQ   + Q    +REQ E R   + EQE +  R ++ Q            +      R
Sbjct: 415 REQQLRREQQL---RREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER 471

Query: 548 LSEQLR-----EKEEQILALEADMTKWEQKYLEERAMRQ 581
             +QL+     E+ E+ L LE +  + +Q+  E++  R+
Sbjct: 472 RKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE 510



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 75/290 (25%), Positives = 129/290 (44%), Gaps = 28/290 (9%)

Query: 313  QMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREAL 372
            + E   RE  +LQ++ E+L RE      +  R  +   + +   +  + L     KR   
Sbjct: 925  EQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQ 984

Query: 373  EKTMRNKMDSEMRRLQDFNRDLRERLESANR----RLASKTQEAQAGSQDMVA-----KL 423
            E+  + + + E++  Q+  + LRE  E   R    R   K  E Q   + ++      + 
Sbjct: 985  EREKKYREEEELQ--QEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR 1042

Query: 424  LAQSYEQQQEQEKLEREMALLRGAIEDQRRRAEL-----LEQALGNAQGRAARAEEELRK 478
            L +   Q +E+E+L++E   L G   + RRR EL      E+ L   + +  R E E R+
Sbjct: 1043 LQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRR 1102

Query: 479  KQ---AYVEKVERLQQALGQ-LQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGS 534
            +Q       + E LQQ   Q L+   EKR + EL  + R E+E+     QQ +       
Sbjct: 1103 RQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEV-----QQEEEQLLREE 1157

Query: 535  SGSGGSPELS-ALRLSEQLREKEEQILALEADMTKW--EQKYLEERAMRQ 581
                   EL    R  E+L+++EEQ+L  E +  +   E++Y EE  +++
Sbjct: 1158 PEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQR 1207



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 81/353 (22%), Positives = 148/353 (41%), Gaps = 39/353 (11%)

Query: 325 QRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASS-KREALEKTMRNKMDSE 383
           +R  ++L+RE E   E+  + ++ E  +Q+   + + L R    +RE L K    K   +
Sbjct: 501 ERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQ 560

Query: 384 MRRLQDFNRDLRERLESANRRLASKTQEAQAGSQD--MVAKLLAQSYEQQQEQEKLEREM 441
            RR Q   R+  ER +   +R   + Q+     Q+  +  +L  +  E+ +++E+  RE 
Sbjct: 561 ERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER--REQ 618

Query: 442 ALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAY--VEKVERLQQAL------ 493
            L R   E++RR+  L  +     + +  R E++ R++Q     E+ ERL+Q L      
Sbjct: 619 RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEE 678

Query: 494 --GQLQAACEKREQLELRLRTRL-----EQELKALRAQQRQAGAPGGSSGSGGSPELSAL 546
              + + A E++EQ   R+++R+     + E +A   Q +    P    G     E    
Sbjct: 679 ERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE---- 734

Query: 547 RLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPS 606
              E+ R +E ++   E +    +Q+  EE   R F     A   ++R    +   P   
Sbjct: 735 -QEEKRRRRESELQWQEEERAHRQQQ--EEEQRRDFTWQWQAEEKSERGRQRLSARP--- 788

Query: 607 PSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQ 659
           P     E  L    R Q  +  L          +   K  ++R RR+  K +Q
Sbjct: 789 PLREQRERQLRAEERQQREQRFL---------PEEEEKEQRRRQRREREKELQ 832



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 68/256 (26%), Positives = 109/256 (42%), Gaps = 24/256 (9%)

Query: 327 DNERLQRELESSAEKAGRIEKLESEIQRLSEA-HESLTRASSKREALEKTMRNKMDSE-- 383
           D E+L+R       + GR EK +   +R      E   +   KRE + +    K+  E  
Sbjct: 206 DEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265

Query: 384 --MRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREM 441
              R LQ+    LR +LE    R   + +E Q        +L  +  E+++EQ++  RE 
Sbjct: 266 QRQRELQEEEEQLR-KLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ 324

Query: 442 ALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACE 501
              R   E++R +    EQ     Q      EEE R++Q   E+ E  ++   QL+   +
Sbjct: 325 QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ--QLRREQQ 382

Query: 502 KREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILA 561
            R + +LR   +L +E +  R QQ +                  LR  +QLR   EQ L 
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLR--------------REQQLRREQQLR--REQQLR 426

Query: 562 LEADMTKWEQKYLEER 577
            E +  + EQK+ +ER
Sbjct: 427 REQEEERHEQKHEQER 442



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 79/345 (22%), Positives = 147/345 (42%), Gaps = 51/345 (14%)

Query: 319 RENARLQRDNERLQRELESSAEKAGRIE---KLESEIQRLSE--AHESLTRASSKREALE 373
           R   +L+R+ ++L+RE +   E+  R E   + E +++R  +    + L R    R   E
Sbjct: 372 RREQQLRRE-QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQE 430

Query: 374 KTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQE 433
           +    +   + RR Q   R+  ER +   R   ++  E +   Q +         ++ QE
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL---------KRDQE 481

Query: 434 QEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQAL 493
           +E+ ER + L     E++R + E  EQ L   Q    R E+ L+++    E+ ERLQQ L
Sbjct: 482 EERRERWLKLEE---EERREQQERREQQLRREQ--EERREQRLKRQ----EEEERLQQRL 532

Query: 494 GQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLR 553
              Q    +REQ E R +    +E K L  ++R+                   RL  +  
Sbjct: 533 RSEQQL--RREQEERREQLLKREEEKRLEQERREQ------------------RLKREQE 572

Query: 554 EKEEQILALEAD-----MTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPS 608
           E+ +Q+L  E +     + + +++ LE+R  R+           +R+  L R  P+    
Sbjct: 573 ERRDQLLKREEERRQQRLKREQEERLEQRLKREEV--ERLEQEERREQRLKREEPEEERR 630

Query: 609 SSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRD 653
               +       R Q++    +    Q L+++   + L+QR +R+
Sbjct: 631 QQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 60/273 (21%), Positives = 120/273 (43%), Gaps = 37/273 (13%)

Query: 320 ENARLQRDNERLQRELE---SSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTM 376
           E A  Q+  E  +R+      + EK+ R  +  S    L E  E   RA  +++  ++ +
Sbjct: 752 ERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFL 811

Query: 377 RNKMDSEMRRLQDFNRD-----LRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQ 431
             + + E RR Q   R+     L E  +   R  A + QE + G Q+          +Q+
Sbjct: 812 PEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE----------DQE 861

Query: 432 QEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQ 491
           + + + +R     R  +E++R+R      A    Q +  + ++ L++++  +++ ER ++
Sbjct: 862 RRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKR 921

Query: 492 ALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQ 551
              + +    + EQL+      L +E +  R Q+R+                   R  ++
Sbjct: 922 RRQEQERQYREEEQLQQEEEQLLREEREKRRRQERE----------------RQYRKDKK 965

Query: 552 LREKEEQILALEADMTK---WEQKYLEERAMRQ 581
           L++KEEQ+L  E +  +    E+KY EE  ++Q
Sbjct: 966 LQQKEEQLLGEEPEKRRRQEREKKYREEEELQQ 998



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 69/345 (20%), Positives = 151/345 (43%), Gaps = 27/345 (7%)

Query: 318 LRENARLQRDNERLQ---RELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEK 374
           L ++ R + D  R +   R+LE    +  R ++ E E + L+E  E     S K+E LE+
Sbjct: 109 LLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQE-RELAEGEEQ----SEKQERLEQ 163

Query: 375 TMRNKMDSEM-RRLQDFN-----RDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSY 428
             R + D E+ R+ Q++      R   E+L+S       +  + +   +  + +L  +  
Sbjct: 164 RDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGR 223

Query: 429 EQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVER 488
           E++Q+Q +  ++        ++ R+R  +L +     Q    + + EL++++  + K+ER
Sbjct: 224 EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLER 283

Query: 489 LQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRL 548
             Q L +     E++E+ + + R R EQ+L+  + ++R+              +    R 
Sbjct: 284 --QELRR-----ERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERRE 336

Query: 549 SEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPS 608
            +  RE+EE+    E  + + +++   E+ +R+   +       +R+  L R        
Sbjct: 337 QQLRREQEER---REQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQ 393

Query: 609 SSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRD 653
               E  L    R Q++    ++   Q L ++  ++  Q+  R +
Sbjct: 394 QLRREQQL---RREQQLRREQQLRREQQLRREQQLRREQEEERHE 435



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 67/269 (24%), Positives = 120/269 (44%), Gaps = 30/269 (11%)

Query: 319 RENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRN 378
           R +  L+R+ ER Q+ L+   E+         E++RL +      R   KRE  E+  R 
Sbjct: 574 RRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL--KREEPEEERRQ 631

Query: 379 KM----DSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQ 434
           ++    + E RR Q   R+ +ER E   +RL  + +E +          L Q  +++ E+
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERRE---QRLKREEEEER----------LEQRLKREHEE 678

Query: 435 EKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALG 494
           E+ E+E+     A E+Q +  E ++  +   Q    + E E   +Q+ V    R Q+   
Sbjct: 679 ERREQEL-----AEEEQEQARERIKSRIPKWQW---QLESEADARQSKVYSRPRKQEGQR 730

Query: 495 QLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQ--L 552
           + Q   EKR + E  L+ + E+     + ++ Q         +    E    RLS +  L
Sbjct: 731 RRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPL 790

Query: 553 REKEEQILALEADMTKWEQKYLEERAMRQ 581
           RE+ E+ L  E +  + EQ++L E   ++
Sbjct: 791 REQRERQLRAE-ERQQREQRFLPEEEEKE 818



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 93/408 (22%), Positives = 162/408 (39%), Gaps = 73/408 (17%)

Query: 313  QMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREAL 372
            Q E  LR   R QR+   L  E E    +  R E+ E E+Q L E  E L R    ++  
Sbjct: 793  QRERQLRAEERQQREQRFLPEEEEKEQRRRQRRER-EKELQFLEE-EEQLQRRERAQQLQ 850

Query: 373  EKTMRNKMDSEMRRLQDFNRD-----------------------LRERLESANRRLASKT 409
            E+    + D E RR Q+  RD                       L+E+L    + L  + 
Sbjct: 851  EEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE 910

Query: 410  QEAQAGSQDMVAKLLAQ-------SYEQQQEQ---------------------EKLEREM 441
            +E Q   ++   +   +         +Q++EQ                     +KL+++ 
Sbjct: 911  EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKE 970

Query: 442  ALLRGAIEDQRRRAE-----LLEQALGNAQGRAARAEEELRKKQAY---VEKVERLQQAL 493
              L G   ++RRR E       E+ L   + +  R E E R++Q +     K + LQQ  
Sbjct: 971  EQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEE 1030

Query: 494  GQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELS-ALRLSEQL 552
             QL    E+RE+  L+ R R  +E + L  QQ +    G    +    EL    R  E+L
Sbjct: 1031 EQLLR--EEREKRRLQERERQYREEEEL--QQEEEQLLGEERETRRRQELERQYRKEEEL 1086

Query: 553  REKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRD----TTLIRHSPQPSPS 608
            +++EEQ+L  E +  + +++  + R   +   +       +R+      L R   +    
Sbjct: 1087 QQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEV 1146

Query: 609  SSFNEGLL---TGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRD 653
                E LL       R QE+E + +       E++ +++  Q++ R++
Sbjct: 1147 QQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQE 1194



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 73/271 (26%), Positives = 119/271 (43%), Gaps = 37/271 (13%)

Query: 320  ENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHES-LTRASSKREALEKTMR- 377
            +  +   D ++L+R+      +  R  K   + Q L E  E  L R    R+ LE+  + 
Sbjct: 1593 QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQL 1652

Query: 378  NKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKL 437
             + + E +   D +R  RE       +L  + +E Q   Q+   K      E++Q+  + 
Sbjct: 1653 RRQEREQQLRHDRDRKFREE-----EQLLQEGEEQQLRRQERDRKFR----EEEQQLRRQ 1703

Query: 438  EREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRK--KQAYVEKVERLQQALGQ 495
            ERE   L+   E+Q+ R + LE        R  R EE+LR+  +Q  + + ER ++ L +
Sbjct: 1704 ERERKFLQ---EEQQLRRQELE--------RKFREEEQLRQETEQEQLRRQERYRKILEE 1752

Query: 496  LQAACEKRE-QLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLR- 553
             Q   E+ E QL  + R R  +E + LR ++ +       S           R  EQLR 
Sbjct: 1753 EQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESD-------RKFREEEQLRQ 1805

Query: 554  EKEEQILALEADMTKW----EQKYLEERAMR 580
            E+EEQ L  +    K+    EQ  LEE+  R
Sbjct: 1806 EREEQQLRPQQRDGKYRWEEEQLQLEEQEQR 1836



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 75/338 (22%), Positives = 140/338 (41%), Gaps = 30/338 (8%)

Query: 315 EAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEK 374
           E  LR   +L+R+ ++L+RE +   E+  R E+     Q+L    E   R   K E   +
Sbjct: 386 EQQLRREQQLRRE-QQLRREQQLRREQQLRREQQLRREQQLRREQEE-ERHEQKHEQERR 443

Query: 375 TMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQ 434
             R K + E RR      +  ER E   R+   K  + +   +  +     +  EQQ+ +
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR 503

Query: 435 E-KLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQAL 493
           E +L RE    R     ++   E L+Q L + Q +  R +EE R++    E+ +RL+Q  
Sbjct: 504 EQQLRREQEERREQRLKRQEEEERLQQRLRSEQ-QLRREQEERREQLLKREEEKRLEQER 562

Query: 494 GQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLR 553
            + +   E+ E+ +  L+   E+  + L+ +Q +                   RL ++L 
Sbjct: 563 REQRLKREQEERRDQLLKREEERRQQRLKREQEE-------------------RLEQRL- 602

Query: 554 EKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNE 613
            K E++  LE +  + ++   EE    +      +    +R    +R   Q        E
Sbjct: 603 -KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQER-----RE 656

Query: 614 GLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSR 651
             L      + +E RLK  H +   +  + +  Q+++R
Sbjct: 657 QRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 59/224 (26%), Positives = 103/224 (45%), Gaps = 25/224 (11%)

Query: 323  RLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKT-MRNKMD 381
            R +R+ + LQ E +   ++  R  + E ++++ +E  E L R    R+ LE+  +R + +
Sbjct: 1702 RQERERKFLQEEQQLRRQELERKFREEEQLRQETE-QEQLRRQERYRKILEEEQLRPERE 1760

Query: 382  SEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREM 441
             +  R Q+ +R  RE       +L  + +E Q  SQ+   K       +++EQ + ERE 
Sbjct: 1761 EQQLRRQERDRKFREE-----EQLRQEREEQQLRSQESDRKF------REEEQLRQEREE 1809

Query: 442  ALLRG-------AIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALG 494
              LR          E+++ + E  EQ L   + R  RAEE+     A  EK  R +Q L 
Sbjct: 1810 QQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQF----ATQEKSRREEQELW 1865

Query: 495  QLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSG 538
            Q +   ++R++ E +LR    +  +    + RQ G      G G
Sbjct: 1866 Q-EEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKG 1908



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 66/336 (19%), Positives = 133/336 (39%), Gaps = 29/336 (8%)

Query: 325  QRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEM 384
            +RD E+ +R  +         E+LE E Q+ ++  +  ++   +    E+  + +     
Sbjct: 1276 ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD 1335

Query: 385  RRLQDFNRDLRERLESANRRLAS--KTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMA 442
            R+ ++  + L+ER E   RR     K +E +   Q+   K L       +E+++L R+  
Sbjct: 1336 RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFL-------EEEQRLRRQER 1388

Query: 443  LLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQAA--- 499
              +   E+Q+ R +  EQ L   + R  R EE+   +Q    K    +Q + + +     
Sbjct: 1389 ERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKF 1448

Query: 500  CEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQI 559
             E+ +QL      +  +E + L+ ++ Q              +L       +  E+E+Q+
Sbjct: 1449 LEEEQQLRQERHRKFREEEQLLQEREEQ--------------QLHRQERDRKFLEEEQQL 1494

Query: 560  LALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGG 619
               E D    EQ+   +   R+F  +       QR    ++   Q        +      
Sbjct: 1495 RRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD 1554

Query: 620  HRHQEMESRLKVLHAQIL---EKDAVIKVLQQRSRR 652
             + +E E   +    Q L   E+D   ++ +Q+ RR
Sbjct: 1555 RKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRR 1590



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 72/337 (21%), Positives = 132/337 (39%), Gaps = 58/337 (17%)

Query: 313  QMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREAL 372
            ++E   R+   LQ++ E+L RE      +  R  +   E + L +  E L R     E  
Sbjct: 1075 ELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREE-EELQQEEEQLLR-----EER 1128

Query: 373  EKTMRNKMDSEMRRLQDFNRD----LRERLESANRRLASKTQEAQAGSQDMVAKLLAQSY 428
            EK  R +++ + R  ++  ++    LRE  E   R+   +    +   Q    +LL +  
Sbjct: 1129 EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQ 1188

Query: 429  E--------QQQEQEKLEREMALLRGAIEDQR------------------------RRAE 456
            E        Q +E+E+L+R+    R   EDQR                        R  E
Sbjct: 1189 EKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENE 1248

Query: 457  LLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQ--------AACEKREQLEL 508
               Q L ++Q R  +++++L+      ++ +R Q+     Q           E+ EQ E 
Sbjct: 1249 QFRQ-LEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEA 1307

Query: 509  RLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTK 568
            + R R  QE K L  ++R+       +      E       + L+E+EEQ L  +    K
Sbjct: 1308 KRRDRKSQEEKQLLREEREEKRRRQETDRKFREE------EQLLQEREEQPLRRQERDRK 1361

Query: 569  WEQKYLEERAM-RQFAMDAAATAAAQRDTTLIRHSPQ 604
            + ++ L  +   R+F  +       +R+   ++   Q
Sbjct: 1362 FREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 67/274 (24%), Positives = 109/274 (39%), Gaps = 33/274 (12%)

Query: 319  RENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRN 378
            RE     ++ ER   E E    +  R  K   E Q+L        R   +     +  + 
Sbjct: 1504 REQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL 1563

Query: 379  KMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQE--- 435
            + + E ++L    RD + RLE    R     QE +    +   +L  Q  +QQ  QE   
Sbjct: 1564 RQEREEQQLSRQERDRKFRLEEQKVR----RQEQERKFMEDEQQLRRQEGQQQLRQERDR 1619

Query: 436  KLEREMALLRGAIEDQRRRAELLEQAL-GNAQGRAARAEEELR--KKQAYVEKVERLQQA 492
            K   +  LL+   E Q  R E   + L    Q R    E++LR  + + + E+ + LQ+ 
Sbjct: 1620 KFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEG 1679

Query: 493  LGQ---LQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLS 549
              Q    Q    K  + E +LR R E+E K L+ +Q                +L    L 
Sbjct: 1680 EEQQLRRQERDRKFREEEQQLR-RQERERKFLQEEQ----------------QLRRQELE 1722

Query: 550  EQLREKEEQILALEADMTKWEQKY---LEERAMR 580
             + RE+E+     E +  + +++Y   LEE  +R
Sbjct: 1723 RKFREEEQLRQETEQEQLRRQERYRKILEEEQLR 1756



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 59/297 (19%), Positives = 124/297 (41%), Gaps = 25/297 (8%)

Query: 319  RENARLQRDNERLQRELESSAE-KAGRIEKLESEIQRLSEAHES-LTRASSKREALEKTM 376
            RE  +  R  ER ++ LE   + +  R  K   E Q L E  E  L R    R+ LE+  
Sbjct: 1433 REEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQ 1492

Query: 377  ---RNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQE 433
               R + D + R  +  +++   +     ++L  + ++ +   ++   +   +  +++Q+
Sbjct: 1493 QLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD 1552

Query: 434  QEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQAL 493
            +++  RE   LR   E+Q+   +  ++     + +  R E+E    + ++E  ++L++  
Sbjct: 1553 RDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQE----RKFMEDEQQLRRQE 1608

Query: 494  GQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLR 553
            GQ Q   E+  +     +   E+E + L  Q+R              P+L      +QLR
Sbjct: 1609 GQQQLRQERDRKFREDEQLLQEREEQQLHRQERD------RKFLEEEPQLRRQEREQQLR 1662

Query: 554  E------KEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQ 604
                   +EE+ L  E +    EQ+   +   R+F  +       +R+   ++   Q
Sbjct: 1663 HDRDRKFREEEQLLQEGE----EQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQ 1715


>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
           [Homo sapiens]
          Length = 1388

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 71/278 (25%), Positives = 125/278 (44%), Gaps = 34/278 (12%)

Query: 311 LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKRE 370
           L Q+E   RE A LQ  N   QR+ +  A+K      LE+++  L +  E L     KR 
Sbjct: 498 LRQLE---REKALLQHKNAEYQRKADHEADKK---RNLENDVNSLKDQLEDL----KKRN 547

Query: 371 ALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQ 430
              +    K++   R+L + N  LR   ++A R      ++ QA S   + +L + + + 
Sbjct: 548 QNSQISTEKVNQLQRQLDETNALLRTESDTAAR-----LRKTQAESSKQIQQLESNNRDL 602

Query: 431 QQE-------QEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYV 483
           Q +       + KLE+E   L+ A+E +RR      + + + QGR    EE+L+  +  +
Sbjct: 603 QDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILL 662

Query: 484 EKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPEL 543
            KVE  ++   QLQ      E+ +  +   +  +LK ++    Q  A           + 
Sbjct: 663 AKVELEKR---QLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEA---------EHKA 710

Query: 544 SALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQ 581
           +  RL+++ +  E    A    M + E+K LEER ++Q
Sbjct: 711 TKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQ 748



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 73/353 (20%), Positives = 152/353 (43%), Gaps = 34/353 (9%)

Query: 322  ARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALE----KTMR 377
            ARL   N+  +   E+ +E    +EK   E + L +  E+L   + KR +L     K  +
Sbjct: 713  ARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQ 772

Query: 378  NKMDSEMRRLQDFNRDLRE---RLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQ 434
             K++  +++    N D+R    ++E   ++      + +  +Q +    +++   +Q+  
Sbjct: 773  QKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENN 832

Query: 435  EKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALG 494
              +E +M L       +++ AEL ++   +A G+    +++L  +Q Y   + + Q  + 
Sbjct: 833  HLMEMKMNL-------EKQNAELRKER-QDADGQMKELQDQLEAEQ-YFSTLYKTQ--VR 881

Query: 495  QLQAACEKREQLELRLRTR---LEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQ 551
            +L+  CE++ +L   L+ +   L+ E  +L AQ         S     S  ++  + S+ 
Sbjct: 882  ELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARS--IAEEQYSDL 939

Query: 552  LREKEEQILALEADMTKWEQKYLE--------ERAMRQFAMDAAATAAAQRDTTLIRHSP 603
             +EK  + L ++  M + +Q+  E        E   R    D A  A  + +        
Sbjct: 940  EKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDV 999

Query: 604  QPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGK 656
            Q   S   +E +     + Q  E +L  L  + L+  AV K+ +  +R++P K
Sbjct: 1000 QEQLSRLKDEEISAAAIKAQ-FEKQL--LTERTLKTQAVNKLAEIMNRKEPVK 1049


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 82/310 (26%), Positives = 132/310 (42%), Gaps = 42/310 (13%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQR-LSEAHESLTRASSKRE 370
            AQM+  ++E   LQ   E L+ ELE+      R+EK  +E  R L E  E L  A     
Sbjct: 1151 AQMQKKIKE---LQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASA 1207

Query: 371  ALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQ 430
               +  R K ++E+ RL       R  LE A  R  +     +    +  A+L  Q    
Sbjct: 1208 GQREGCR-KREAELGRL-------RRELEEAALRHEATVAALRRKQAEGAAELGEQVDSL 1259

Query: 431  QQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVE--- 487
            Q+ ++KLE+E + LR  ++D     E L +A  +A+      E++L + +  VE+++   
Sbjct: 1260 QRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQL 1319

Query: 488  --------RLQQALGQLQAACEKREQLELRL---RTRLEQELKALRAQQRQAGAPGGSSG 536
                    RLQ   G+L    E++E L  +L   +    Q L+ LR Q  +       + 
Sbjct: 1320 ADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEE----SKAK 1375

Query: 537  SGGSPELSALR-----LSEQLREKEEQILALE-------ADMTKWEQKYLEERAMRQFAM 584
            S  +  + ALR     L EQ  E+ E    L+       A++ +W  KY  +   R   +
Sbjct: 1376 SALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEEL 1435

Query: 585  DAAATAAAQR 594
            + A    A R
Sbjct: 1436 EEAKKKLALR 1445



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 71/282 (25%), Positives = 121/282 (42%), Gaps = 34/282 (12%)

Query: 328  NERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRL 387
            +ERL+ E E +A+ A R  KLE E   L +  + L    +K E  ++   NK+ +    +
Sbjct: 972  SERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEM 1031

Query: 388  QDFNRDLRERLESANRRLASKTQEAQA---GSQDMVAKLLAQSYEQQQEQEKLE---REM 441
               +  +  RL    + L    Q+A       +D V+ L       +Q+ E LE    + 
Sbjct: 1032 AALDESV-ARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQE 1090

Query: 442  ALLRGAIEDQRRRAE----LLEQALGNAQGRAARAEEELRKKQAYVEKVE---------- 487
              LR   E  +R+ E    L ++++ +A     + EE+L+KK + + ++           
Sbjct: 1091 KKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLG 1150

Query: 488  -RLQQALGQLQAACEKRE---QLELRLRTRLE-------QELKALRAQQRQAGAPGGSSG 536
             ++Q+ + +LQA  E+ E   + E   R R+E       +EL+ L  +  +AG  G S+G
Sbjct: 1151 AQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAG--GASAG 1208

Query: 537  SGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERA 578
                       L    RE EE  L  EA +    +K  E  A
Sbjct: 1209 QREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAA 1250



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 67/270 (24%), Positives = 130/270 (48%), Gaps = 43/270 (15%)

Query: 294  EGPVSAQASSATSGSAHLAQMEAVL--------RENARLQRDNERLQRELESS--AEKAG 343
            EG +  + +        L+Q++A +         E A L+R+++R    L++S  AE   
Sbjct: 1597 EGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRA 1656

Query: 344  RIE------KLESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNR---DL 394
            R E      K+E ++  L       TR +++ +A  + M+ ++  E     +  R   +L
Sbjct: 1657 RNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAEL 1716

Query: 395  RERLESANRR---LASKTQEAQAG------SQDMVAKLLAQSYEQQQ-----------EQ 434
             E+ ++  RR   LA++ +E +A       S+ +  + L ++ E+             ++
Sbjct: 1717 HEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQK 1776

Query: 435  EKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQ---AYVEKVER-LQ 490
            +KLE ++A L G +E+  +     E+    A   AA   EEL+K+Q   A++E++++ L+
Sbjct: 1777 KKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLE 1836

Query: 491  QALGQLQAACEKREQLELRLRTRLEQELKA 520
            Q + +LQA  E+ EQ  LR   +  Q+L+A
Sbjct: 1837 QTVRELQARLEEAEQAALRGGKKQVQKLEA 1866



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 83/360 (23%), Positives = 159/360 (44%), Gaps = 30/360 (8%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQR-LSEAHESLTRASSKRE 370
            A+  ++ +   RLQ ++E +  ELE +   A  ++K +  ++R L E          + E
Sbjct: 1458 AKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELE 1517

Query: 371  ALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQ 430
            A ++  R  + +E+ RL+  + +  E LE+  R      QE  +   D V+       E 
Sbjct: 1518 AAQRESRG-LGTELFRLRHGHEEALEALETLKRE-NKNLQEEISDLTDQVSLSGKSIQEL 1575

Query: 431  QQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERL- 489
            ++ ++ LE E + ++ A+E+     EL E      Q   ++ + E+ +K A  EK E   
Sbjct: 1576 EKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLA--EKDEECA 1633

Query: 490  ------QQALGQLQAA--CEKREQLE-LRLRTRLEQELKALRAQQRQAGAPGGSSGSGGS 540
                  Q+A+  LQA+   E R + E LRL+ ++E +L  L  Q   A     +     +
Sbjct: 1634 NLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHA-TRQATEAQAAT 1692

Query: 541  PELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAM--------RQFAMDAAATAAA 592
              + A    EQ    EEQ LA E      + + LE RA          + A++    +  
Sbjct: 1693 RLMQAQLKEEQAGRDEEQRLAAELHE---QAQALERRASLLAAELEELRAALEQGERSRR 1749

Query: 593  QRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRR 652
              +  L+  + + +   S N GLL   ++ +++E+ L  L  ++ E     +  ++++++
Sbjct: 1750 LAEQELLEATERLNLLHSQNTGLL---NQKKKLEADLAQLSGEVEEAAQERREAEEKAKK 1806



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 77/352 (21%), Positives = 142/352 (40%), Gaps = 33/352 (9%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQ-RLSEAHESLTRASSKR 369
            L  +E + REN  LQ +   L  ++  S +    +EK +  ++   SE   +L  A    
Sbjct: 1541 LEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGAL 1600

Query: 370  EALE-KTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSY 428
            E  E KT+R +++     L     ++  +L   +   A+  +  Q   + + A L A++ 
Sbjct: 1601 ELEETKTLRIQLE-----LSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAET- 1654

Query: 429  EQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVER 488
              + E  +L+++M    G + D       LE  LG+A  +A  A+   R  QA +++ + 
Sbjct: 1655 RARNEALRLKKKM---EGDLND-------LELQLGHATRQATEAQAATRLMQAQLKEEQA 1704

Query: 489  LQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRL 548
             +    +L A   ++ Q   R  + L  EL+ LRA   Q              E S    
Sbjct: 1705 GRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQG-------------ERSRRLA 1751

Query: 549  SEQLREKEEQILALEADMT-KWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSP 607
             ++L E  E++  L +  T    QK   E  + Q + +    A  +R+    +     + 
Sbjct: 1752 EQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAE-EKAKKAITD 1810

Query: 608  SSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQ 659
            ++   E L         +E   K L   + E  A ++  +Q + R   K +Q
Sbjct: 1811 AAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQ 1862



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 92/422 (21%), Positives = 174/422 (41%), Gaps = 52/422 (12%)

Query: 319  RENARLQRDNERLQRELESSAEK----AGRIEKLESEIQRLSEAHES-------LTRASS 367
            R  A   +  E L+R+LE  ++     A  ++ L  +   L E HE        L R  S
Sbjct: 1352 RGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLS 1411

Query: 368  KREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAK----- 422
            K  A     R+K +++  +         E LE A ++LA + QEA+ G +   AK     
Sbjct: 1412 KANAEVAQWRSKYEADAIQ-------RTEELEEAKKKLALRLQEAEEGVEAANAKCSSLE 1464

Query: 423  -----LLAQSYEQQQEQEK-------LEREMALLRGAIEDQRRRAELLEQALGNAQGRAA 470
                 L  +S +   E E+       L+++   L  A+E++RR+ E +++ L  AQ  + 
Sbjct: 1465 KAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESR 1524

Query: 471  RAEEEL-RKKQAYVEKVERLQQALGQLQAACEK----REQLELRLRT--RLEQELKALRA 523
                EL R +  + E +E L+    + +   E+     +Q+ L  ++   LE+  KAL  
Sbjct: 1525 GLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEG 1584

Query: 524  QQRQ-AGAPGGSSGSGGSPELSALRLSEQLREKEEQI--LALEADMTKWEQKYLEERAMR 580
            ++ +   A   + G+    E   LR+  +L + + ++     E D      +   +RA+ 
Sbjct: 1585 EKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVE 1644

Query: 581  QFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGH---RHQEMESRLKVLHAQIL 637
                   A   A+ +   ++   +       N+  L  GH   +  E ++  +++ AQ+ 
Sbjct: 1645 SLQASLDAETRARNEALRLKKKME----GDLNDLELQLGHATRQATEAQAATRLMQAQLK 1700

Query: 638  EKDAVIKVLQQRSRRDPGKAIQGSLRPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPA 697
            E+ A     Q+ +     +A     R +     +    AA  QG +    +E++  +A  
Sbjct: 1701 EEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATE 1760

Query: 698  RL 699
            RL
Sbjct: 1761 RL 1762



 Score = 38.1 bits (87), Expect = 0.032
 Identities = 29/137 (21%), Positives = 62/137 (45%), Gaps = 7/137 (5%)

Query: 308  SAHLAQMEAVLREN-----ARLQRDNERLQRELESSAEKA-GRIEKLESEIQRLSEAHES 361
            SAHL +M+  L +      ARL+   +   R  +   +K   ++ +LE+E+    + H  
Sbjct: 1825 SAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAE 1884

Query: 362  LTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVA 421
              +   K E   K +  + + + + L    +DL ++L+S  +    + +EA+  +   +A
Sbjct: 1885 ALKGVRKHERRVKELAYQAEEDRKNLARM-QDLVDKLQSKVKSYKRQFEEAEQQANTNLA 1943

Query: 422  KLLAQSYEQQQEQEKLE 438
            K     +E    +E+ +
Sbjct: 1944 KYRKAQHELDDAEERAD 1960


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 66/285 (23%), Positives = 129/285 (45%), Gaps = 27/285 (9%)

Query: 294 EGPVSAQASSATSGSAHLAQMEAVLRENA-RLQRDNERLQRELESSAEKAGRIEKLESEI 352
           EG V  Q          + + E  + E   ++    E++Q++ E   E+  ++ K E   
Sbjct: 177 EGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQE--- 233

Query: 353 QRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEA 412
           +++ E  E + +   + +  E+ MR K + +MR  ++    +RE+ E   ++     QE 
Sbjct: 234 EQMGEQEEQVQKQEEQVQKQEEQMR-KQEEQMREQEE---QMREQEEQMLKQKEQTEQEE 289

Query: 413 QAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARA 472
           Q G Q+   + + +  EQ +EQE+  RE        E+Q  + E  EQ     +    + 
Sbjct: 290 QTGEQE---EQMREQEEQMREQEEQMREQEEQMREQEEQMGKQE--EQMWEQKEQMWEQK 344

Query: 473 EEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPG 532
           E+  ++++   E+ E++Q+   Q++   E+  + E ++R + EQ    +R Q+ Q G   
Sbjct: 345 EQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQ----MRKQEEQMGEQK 400

Query: 533 GSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEER 577
              G             EQ+RE+EEQ+   +  M K E+   E++
Sbjct: 401 EQMGEQ----------KEQMREQEEQMGEQKEQMRKQEEHMGEQK 435



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 62/292 (21%), Positives = 126/292 (43%), Gaps = 5/292 (1%)

Query: 290 PPAVEGPVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSA-EKAGRIEKL 348
           P   EG V  Q          + + E  +RE     R+ E   RE E    E+ G++ + 
Sbjct: 47  PLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 106

Query: 349 ESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLAS- 407
           E +++              ++E   +    ++  +  ++++    +RE+      +    
Sbjct: 107 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 166

Query: 408 KTQEAQAGSQD-MVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQ 466
           + QE Q   Q+  V +   Q  EQ+ +  + E +M      + +Q  + +  E+ +G  +
Sbjct: 167 REQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQE 226

Query: 467 GRAARAEEELRKKQAYVEKVE-RLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQ 525
            +  + EE++ +++  V+K E ++Q+   Q++   E+  + E ++R + EQ LK  + Q 
Sbjct: 227 EQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQ-KEQT 285

Query: 526 RQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEER 577
            Q    G         E       EQ+RE+EEQ+   E  M K E++  E++
Sbjct: 286 EQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQK 337



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 58/288 (20%), Positives = 121/288 (42%), Gaps = 12/288 (4%)

Query: 294 EGPVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSA-EKAGRIEKLESEI 352
           EG V  Q          + + E  +RE     R+ E   RE E    E+ G++ + E ++
Sbjct: 121 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 180

Query: 353 QRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEA 412
           +              ++E        +M  +  ++Q     + E+ E   +      QE 
Sbjct: 181 REQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRK------QEE 234

Query: 413 QAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAE--LLEQALGNAQGRAA 470
           Q G Q+   +   +  ++Q+EQ + + E   +R   E  R + E  L ++     + +  
Sbjct: 235 QMGEQEEQVQKQEEQVQKQEEQMRKQEEQ--MREQEEQMREQEEQMLKQKEQTEQEEQTG 292

Query: 471 RAEEELRKKQAYV-EKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAG 529
             EE++R+++  + E+ E++++   Q++   E+  + E ++  + EQ  +      +Q  
Sbjct: 293 EQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEE 352

Query: 530 APGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEER 577
             G         E    +  EQ+R++EEQ+   E  M K E++  E++
Sbjct: 353 QMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQK 400



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 47/238 (19%), Positives = 105/238 (44%), Gaps = 2/238 (0%)

Query: 346 EKLESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRL 405
           E+L+ +   L E  + +    S+ +   K ++ K++++   L    +   +  +   +  
Sbjct: 7   EELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEG 66

Query: 406 ASKTQEAQAGSQD-MVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGN 464
             + QE Q   Q+  V +   Q  EQ+ +  + E ++    G + +Q  +    E  +  
Sbjct: 67  QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 126

Query: 465 AQGRAARAEEELRKKQAYVEKVE-RLQQALGQLQAACEKREQLELRLRTRLEQELKALRA 523
            +G+    E ++R+++  V + E ++++  GQ++    +  + E ++R +  Q  +    
Sbjct: 127 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 186

Query: 524 QQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQ 581
            + Q G  G   G  G  E       EQ++++EEQ+   E  M K E++  E+    Q
Sbjct: 187 VREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQ 244


>gi|203096856 kinesin family member 7 [Homo sapiens]
          Length = 1343

 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 104/397 (26%), Positives = 171/397 (43%), Gaps = 69/397 (17%)

Query: 300  QASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAH 359
            Q   AT+    LAQ +  +RE A   R  E L  EL  + + A  + +  S  QR+ E  
Sbjct: 692  QVPPATASEWRLAQAQQKIRELAINIRMKEELIGELVRTGKAAQALNRQHS--QRIRELE 749

Query: 360  ESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDM 419
            +    A   R  L +  R   + E + LQD     R RL+   RR+A+      A SQ  
Sbjct: 750  Q---EAEQVRAELSEGQRQLRELEGKELQDAGE--RSRLQEFRRRVAA------AQSQVQ 798

Query: 420  VAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKK 479
            V K      E++Q  E+L    A     +++  R  +L+ Q  G  Q R     E+ R+ 
Sbjct: 799  VLK------EKKQATERLVSLSAQSEKRLQELERNVQLMRQQQGQLQRRLREETEQKRRL 852

Query: 480  QAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGG 539
            +A   ++ + Q  + +L+   E+++++ L+++T   +E+ A + ++R        SGS G
Sbjct: 853  EA---EMSKRQHRVKELELKHEQQQKI-LKIKT---EEIAAFQRKRR--------SGSNG 897

Query: 540  SPELSALRLSEQLREKEEQILALEADMTKWEQ-----KYLEERAMRQFAMDAAATAAAQR 594
            S     +   EQ ++ EEQ   L+ +M K  Q     + L E   ++ A+ A   A  Q 
Sbjct: 898  S-----VVSLEQQQKIEEQKKWLDQEMEKVLQQRRALEELGEELHKREAILAKKEALMQE 952

Query: 595  DTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQI------------------ 636
             T L   S +   S + NE ++    R + +E  L     Q+                  
Sbjct: 953  KTGL--ESKRLRSSQALNEDIVRVSSRLEHLEKELSEKSGQLRQGSAQSQQQIRGEIDSL 1010

Query: 637  -LEKDAVIKVLQQRSRRDPGKAIQGSLRPAKSVPSVF 672
              EKD+++K   QR   D GK  QGSL   +   ++F
Sbjct: 1011 RQEKDSLLK---QRLEID-GKLRQGSLLSPEEERTLF 1043



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 71/279 (25%), Positives = 115/279 (41%), Gaps = 38/279 (13%)

Query: 324  LQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMDSE 383
            L+   +  +R +  SA+   R+++LE  +Q + +    L R    R   E   + ++++E
Sbjct: 800  LKEKKQATERLVSLSAQSEKRLQELERNVQLMRQQQGQLQR----RLREETEQKRRLEAE 855

Query: 384  MRRLQDFNRDLRERLESANRRLASKTQEAQA-------GSQDMVAKLLAQSYEQQQEQEK 436
            M + Q   ++L  + E   + L  KT+E  A       GS   V  L     EQQQ+ E+
Sbjct: 856  MSKRQHRVKELELKHEQQQKILKIKTEEIAAFQRKRRSGSNGSVVSL-----EQQQKIEE 910

Query: 437  LEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQL 496
             ++ +      +  QRR  E L + L   +   A+ E  +++K     K  R  QAL + 
Sbjct: 911  QKKWLDQEMEKVLQQRRALEELGEELHKREAILAKKEALMQEKTGLESKRLRSSQALNED 970

Query: 497  QAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKE 556
                  R +        LE+EL     Q RQ  A       G   E+ +LR  +    K+
Sbjct: 971  IVRVSSRLE-------HLEKELSEKSGQLRQGSAQSQQQIRG---EIDSLRQEKDSLLKQ 1020

Query: 557  EQILALEADMTKWEQKYL---EERAMRQF-----AMDAA 587
                 LE D    +   L   EER + Q      A+DAA
Sbjct: 1021 R----LEIDGKLRQGSLLSPEEERTLFQLDEAIEALDAA 1055



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 58/247 (23%), Positives = 104/247 (42%), Gaps = 35/247 (14%)

Query: 286  SSLSPPAVEGPVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRI 345
            S+ S   + G + +      S      +++  LR+ + L  + ER   +L+ +      I
Sbjct: 996  SAQSQQQIRGEIDSLRQEKDSLLKQRLEIDGKLRQGSLLSPEEERTLFQLDEA------I 1049

Query: 346  EKLESEIQRLSEA---HESLTRAS-SKREALEKTMRNKMD----SEMRRL--QDFNRDLR 395
            E L++ I+  +EA    + + RAS S     E  +  K+     SE R L  + F++ + 
Sbjct: 1050 EALDAAIEYKNEAITCRQRVLRASASLLSQCEMNLMAKLSYLSSSETRALLCKYFDKVVT 1109

Query: 396  ERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQ---------EQEKLEREMALLRG 446
             R E   +++A    E Q   Q  +   L  + E+Q+         +Q++ E+ M LL  
Sbjct: 1110 LREEQHQQQIAFSELEMQLEEQQRLVYWLEVALERQRLEMDRQLTLQQKEHEQNMQLLLQ 1169

Query: 447  --------AIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQA 498
                     + D RR+ E   QAL    GR     +EL++K   V  V   +   G+ ++
Sbjct: 1170 QSRDHLGEGLADSRRQYEARIQALEKELGRYMWINQELKQKLGGVNAVGHSRG--GEKRS 1227

Query: 499  ACEKREQ 505
             C +  Q
Sbjct: 1228 LCSEGRQ 1234



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 58/319 (18%), Positives = 129/319 (40%), Gaps = 45/319 (14%)

Query: 303  SATSGSA-HLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHES 361
            S ++GS   L Q + +  +   L ++ E++ ++  +  E    + K E+ + +     + 
Sbjct: 893  SGSNGSVVSLEQQQKIEEQKKWLDQEMEKVLQQRRALEELGEELHKREAILAKKEALMQE 952

Query: 362  LTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVA 421
             T   SKR    + +   +     RL+   ++L E+     R+ ++++Q+   G  D + 
Sbjct: 953  KTGLESKRLRSSQALNEDIVRVSSRLEHLEKELSEK-SGQLRQGSAQSQQQIRGEIDSLR 1011

Query: 422  K----LLAQ--------------SYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALG 463
            +    LL Q              S E+++   +L+  +  L  AIE +       ++ L 
Sbjct: 1012 QEKDSLLKQRLEIDGKLRQGSLLSPEEERTLFQLDEAIEALDAAIEYKNEAITCRQRVLR 1071

Query: 464  NAQGRAARAEEELRKKQAYV--------------------EKVERLQQALGQLQAACEKR 503
             +    ++ E  L  K +Y+                    E+  + Q A  +L+   E++
Sbjct: 1072 ASASLLSQCEMNLMAKLSYLSSSETRALLCKYFDKVVTLREEQHQQQIAFSELEMQLEEQ 1131

Query: 504  EQLELRLRTRLEQELKALRAQ---QRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQIL 560
            ++L   L   LE++   +  Q   Q++            S +     L++  R+ E +I 
Sbjct: 1132 QRLVYWLEVALERQRLEMDRQLTLQQKEHEQNMQLLLQQSRDHLGEGLADSRRQYEARIQ 1191

Query: 561  ALEADMTK--WEQKYLEER 577
            ALE ++ +  W  + L+++
Sbjct: 1192 ALEKELGRYMWINQELKQK 1210


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 171/718 (23%), Positives = 282/718 (39%), Gaps = 146/718 (20%)

Query: 1    MRTLEDSSGTVLHRLIQEQLRYGNLT--ETRTLLAIQQQAL--RGGAGTGGTGSPQASLE 56
            ++ LED   T   ++++E L    L+  E    L  Q+Q +  R   G G + + + SLE
Sbjct: 1667 IQVLEDQR-TRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLE 1725

Query: 57   ----ILAPEDSQV------------LQQATRQEPQGQEHQGGENHLA----ENTLYRLCP 96
                IL  ++ +V            L+    Q+ QG   + GE  L     E  +  L  
Sbjct: 1726 HMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQ 1785

Query: 97   QPSKGEELPTYEEAKAHSQYYAAQQAGTRP----HAGDRDPRGAPGGSRRQDE---ALR- 148
            Q  +  E    +E    SQ   AQ+A  +      A  ++ + A G   R  E   AL+ 
Sbjct: 1786 QLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQG 1845

Query: 149  ELRHGHVRSLSERLLQLSLERNGARAPSHMSSSHSFPQLARNQQGPPLRGPPAEGPESR- 207
             L   H+ +L ER  +L   +  AR      +       A  +    LR    E  ++  
Sbjct: 1846 ALEQAHM-TLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALL 1904

Query: 208  GPPPQYPHVVLAHETTT-AVTDPRYRARGSPHFQHAEVRILQAQVPPVFLQQQQQYQYLQ 266
                Q       HE  T A+ D   +A+     +  E+  L+A+      Q++      +
Sbjct: 1905 ALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAE 1964

Query: 267  QSQEHPPPPHPAALG---HGPLSSLSPPAVEGPVSAQASSATSGSAHLAQMEAVLR---- 319
              QE     H A  G   H    +    ++E   +   +S  +  AH  Q+E  LR    
Sbjct: 1965 ALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEG 2024

Query: 320  ----------------ENARLQRDNE-RLQRELESSAEK--AGRIEK----------LES 350
                            + A  QRD E R Q+E E   EK  A R+++           E 
Sbjct: 2025 EIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQER 2084

Query: 351  EIQRLSEAHES-----LTRASSKREALE---KTMRN-------------------KMDSE 383
            E + +   H+S     LT A  ++E LE      RN                   K+DS 
Sbjct: 2085 EEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSL 2144

Query: 384  MRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLL-----------------AQ 426
              RLQ   R+L ERL++A R+  ++  E +  +QD+   L                  A 
Sbjct: 2145 EPRLQ---REL-ERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQAS 2200

Query: 427  SYEQQQEQEKLEREMALLRGAIEDQRRR-------AELLEQA-----LGNAQGRAARAEE 474
              E+  EQ++L+ E+ L R A+E +R         AEL  +      LG   G  A    
Sbjct: 2201 VLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSP 2260

Query: 475  ELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQ------ELKALRAQQRQA 528
            +  +KQ++ +++E LQQA+ +L+    + ++  ++LR+ LEQ      +LK    +  QA
Sbjct: 2261 DGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQA 2320

Query: 529  GAPGGSSGSGGSPELSALRLSEQ-----LREKEEQILALEADMT---KWEQKYLEERA 578
            G+   S  +  SP     R  +      + E +++++ L+A +T   K +Q Y+   A
Sbjct: 2321 GSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSA 2378



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 93/382 (24%), Positives = 160/382 (41%), Gaps = 60/382 (15%)

Query: 294  EGPVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEI- 352
            +GP  AQ  S       L  M+ +LR+           ++E+E   E    +++L+ ++ 
Sbjct: 1714 KGPSKAQRGS-------LEHMKLILRDK----------EKEVECQQEHIHELQELKDQLE 1756

Query: 353  QRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEA 412
            Q+L   H  +   S         + ++ + E+  LQ   ++ RE+ E   + L S+  EA
Sbjct: 1757 QQLQGLHRKVGETS--------LLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEA 1808

Query: 413  QAGSQDMVAKLLAQSYEQQQEQ---EKLEREMALLRGAIEDQRRRAELLEQALGNAQGRA 469
            Q        +L A   EQQQ Q   E+++ +   L+GA+E      +     L + + +A
Sbjct: 1809 QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQA 1868

Query: 470  ARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRL-------EQELKALR 522
             R EEEL  +     +V+ L++ LG L+A   ++E+  L L+ +        E E +AL+
Sbjct: 1869 RRLEEELAVEG---RRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQ 1925

Query: 523  AQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEAD------------MTKWE 570
                QA A           EL ALR   Q    +E+     A+            +   E
Sbjct: 1926 DSWLQAQAVLKER----DQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKE 1981

Query: 571  QKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGH-RHQEMESRL 629
            Q  LE+  + +    + AT  A  D     HS Q   +    EG +     R+QE   +L
Sbjct: 1982 QHLLEQAELSRSLEASTATLQASLDACQ-AHSRQLEEALRIQEGEIQDQDLRYQEDVQQL 2040

Query: 630  KVLHAQILEKDAVIKVLQQRSR 651
            +   AQ   +D  ++  Q+R +
Sbjct: 2041 QQALAQ---RDEELRHQQEREQ 2059



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 113/506 (22%), Positives = 187/506 (36%), Gaps = 93/506 (18%)

Query: 319  RENARLQRDNERLQRELESSAEKAGRIE-KLESEIQRLSEAHESLTRASSKREALEKTMR 377
            +E   LQ++ ++ Q + E   EKA  ++  LE     L E H  L     +   LE+ + 
Sbjct: 1817 QELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELA 1876

Query: 378  NKMDSEMRRLQDFNRDLRERLESANRRLASKTQEA--QAGSQDMVAKLLAQSY------- 428
             +    ++ L++   DLR       + L +  Q+   QA   ++  + L  S+       
Sbjct: 1877 VE-GRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVL 1935

Query: 429  -EQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNA---------------------- 465
             E+ QE E L  E    R   E  R RAE L++ALG A                      
Sbjct: 1936 KERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLE 1995

Query: 466  -------------QGRAARAEEELRKKQA--------YVEKVERLQQALGQLQAACEKRE 504
                         Q  + + EE LR ++         Y E V++LQQAL Q       ++
Sbjct: 1996 ASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQ 2055

Query: 505  QLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEA 564
            + E  L   L Q ++    Q++Q               L   R  E++R   + +  L+ 
Sbjct: 2056 EREQLLEKSLAQRVQENMIQEKQ--------------NLGQEREEEEIRGLHQSVRELQL 2101

Query: 565  DMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQE 624
             + + EQ+ LE R  +Q           + +   + HS + SP     E  L        
Sbjct: 2102 TLAQKEQEILELRETQQ-----------RNNLEALPHSHKTSP---MEEQSLKLDSLEPR 2147

Query: 625  MESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQGSLRPAKSVPSVFAAAAAGTQGWQG 684
            ++  L+ L A + + +A     ++   R+  + +  SL   K+  S     A   Q    
Sbjct: 2148 LQRELERLQAALRQTEA-----REIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVL 2202

Query: 685  LSSSERQTADAPARLTTADRAPTEEPVVTAPPAAHAKHGSRDGSTQTEGPPDSTSTCLPP 744
               SE+Q       LT   RA  +E + +    + A+ GSR       G          P
Sbjct: 2203 ERDSEQQRLQDELELTR--RALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEA--EP 2258

Query: 745  EPDSLLGCSSSQRAASLDSVATSRVQ 770
             PD +   S  QR   L   A +R++
Sbjct: 2259 SPDGMEKQSWRQRLEHLQQ-AVARLE 2283



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 84/350 (24%), Positives = 146/350 (41%), Gaps = 41/350 (11%)

Query: 329 ERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQ 388
           +RLQ+        AG+   L+ E+  LS+  E L +A   RE L + +   ++ E  RL+
Sbjct: 435 QRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKA---REELRQQL-EVLEQEAWRLR 490

Query: 389 DFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAI 448
             N +L+ + +SA  +   + +E     ++   +L       + +Q +   E+  LR A+
Sbjct: 491 RVNVELQLQGDSAQGQKEEQQEELHLAVRER-ERLQEMLMGLEAKQSESLSELITLREAL 549

Query: 449 EDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLEL 508
           E      ELL Q         ARAE+ + +  +       L+  +  L+AA  K   L  
Sbjct: 550 ESSHLEGELLRQEQTEVTAALARAEQSIAELSS---SENTLKTEVADLRAAAVKLSALNE 606

Query: 509 RL---RTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEAD 565
            L   +  L Q+L  L  + +                 S +  +EQ R   +  LA EA+
Sbjct: 607 ALALDKVGLNQQLLQLEEENQSV--------------CSRMEAAEQARNALQVDLA-EAE 651

Query: 566 MTK---WEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFN--EGLLTGGH 620
             +   WE+    E  +++     A   A  RD    +   Q   S S +  E   T   
Sbjct: 652 KRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLE 711

Query: 621 R-HQEMESRLKVLHAQILEKDAVIKV-------LQ--QRSRRDPGKAIQG 660
           + HQE + + +VL   + EK+A+++        LQ  +R R+D  + +QG
Sbjct: 712 QLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQG 761



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 94/412 (22%), Positives = 167/412 (40%), Gaps = 47/412 (11%)

Query: 313 QMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQ--------RLSEAHESLTR 364
           +++++ +E   LQ+  E L+++LE   ++A R+ ++  E+Q        +  E  E L  
Sbjct: 457 EVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHL 516

Query: 365 ASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESAN------RRLASKTQEAQAGSQD 418
           A  +RE L++ +      +   L +    LRE LES++      R+  ++   A A ++ 
Sbjct: 517 AVRERERLQEMLMGLEAKQSESLSEL-ITLREALESSHLEGELLRQEQTEVTAALARAEQ 575

Query: 419 MVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRK 478
            +A+L          +  L+ E+A LR A        E L         +  + EEE + 
Sbjct: 576 SIAEL-------SSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQS 628

Query: 479 KQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSG 538
             + +E  E+ + AL    A  EKR +      T LE +L+  +A++  A          
Sbjct: 629 VCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQ--KAEEAGAELQADLRDIQ 686

Query: 539 GSPELSALRLSEQLREKEEQILALEA--DMTKWEQKYL------EERAMRQFAMDAAATA 590
              E    +LSE   ++E     LE      K +++ L      +E  +R+ A       
Sbjct: 687 EEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQ 746

Query: 591 AAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRS 650
           A +RD   +  + Q    SS  E L +     Q+  S ++V   Q+   +  I+ + Q  
Sbjct: 747 AVERDRQDL--AEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQL---EVQIQTVTQAK 801

Query: 651 RRDPGKAIQGSLRPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPARLTTA 702
                + IQG +R  K            +Q  Q   ++ RQ A A     TA
Sbjct: 802 -----EVIQGEVRCLK-----LELDTERSQAEQERDAAARQLAQAEQEGKTA 843



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 90/477 (18%), Positives = 202/477 (42%), Gaps = 48/477 (10%)

Query: 313  QMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREAL 372
            Q++ V +    +Q +   L+ EL++   +A   ++ ++  ++L++A +    A  +++A 
Sbjct: 793  QIQTVTQAKEVIQGEVRCLKLELDTERSQAE--QERDAAARQLAQAEQEGKTALEQQKAA 850

Query: 373  EKTMRNKMDSEMRRLQDFNR-DLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQ 431
             +   N++  +  + + +++ +L + LES  R         +    +M      ++ + Q
Sbjct: 851  HEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEM------EAIQAQ 904

Query: 432  QEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERL-- 489
            +E+E+ + E AL +  +E ++ R  LLE  L   Q   A A ++L + +  + KV++L  
Sbjct: 905  REEERTQAESALCQMQLETEKERVSLLETLL-QTQKELADASQQLERLRQDM-KVQKLKE 962

Query: 490  QQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLS 549
            Q+  G LQ   ++ ++    L+    Q    L A Q ++           S     + L 
Sbjct: 963  QETTGILQTQLQEAQR---ELKEAARQHRDDLAALQEES----------SSLLQDKMDLQ 1009

Query: 550  EQLREKEEQILALEADMTKWEQKYLEE--------RAMRQFAMDAAATAAA--QRDTTLI 599
            +Q+ + + Q++A +      EQ+  E+        R  ++   + A+   +  +++  L+
Sbjct: 1010 KQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLL 1069

Query: 600  ----RHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDA--VIKVLQQRSRRD 653
                  S +    S+  + +       +E+ +++++L  ++ EK+A  + +  Q     +
Sbjct: 1070 VLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELE 1129

Query: 654  PGKAIQGSLRPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPARLTTADRAPTEEPVVT 713
                 +  LR      S++A  A   Q    L S+E Q     A     ++A  +  + +
Sbjct: 1130 ASHITEQQLR-----ASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLAS 1184

Query: 714  APPAAHAKHGS-RDGSTQTEGPPDSTSTCLPPEPDSLLGCSSSQRAASLDSVATSRV 769
               A     GS  +   +  G  DS  +    EPD     S  +R   L +++   V
Sbjct: 1185 LYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAV 1241



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 84/407 (20%), Positives = 172/407 (42%), Gaps = 82/407 (20%)

Query: 324  LQRDNERLQRELESSAEKAGRIEKLESEIQRL----SEAHESLTRASSKREALEK---TM 376
            L  D ++  +E++   E+   +EK  S ++ L     E  + LT    +   LEK   T 
Sbjct: 1461 LSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQ 1520

Query: 377  RNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEK 436
            RN ++ ++  L+  ++ +       ++R   +  + Q  + + +A  L +++ + + Q+K
Sbjct: 1521 RNVLEHQLLELEKKDQMIE------SQRGQVQDLKKQLVTLECLALELEENHHKMECQQK 1574

Query: 437  LEREM---------ALLRGAIEDQRRRAELLEQA--LGNAQGRAARAEEELRKKQAYV-- 483
            L +E+         AL    ++ + R  EL  Q+  + + +  +     EL+++   V  
Sbjct: 1575 LIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKS 1634

Query: 484  --EKVERLQQALGQLQAACEKREQLELRL-----------RTR----LEQELKALRAQQR 526
              E++E LQ+    L    E+R+Q EL L           RTR    LE++L+ ++   R
Sbjct: 1635 QREQIEELQRQKEHLTQDLERRDQ-ELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLR 1693

Query: 527  QAG----------------APGGSSGSGGSPELSALRLSEQLRE---KEEQILALEADMT 567
            + G                  G S    GS E   L L ++ +E   ++E I  L+    
Sbjct: 1694 ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKD 1753

Query: 568  KWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMES 627
            + EQ+   +   R+    +   +  +++  +++   Q        E    G  + Q ++S
Sbjct: 1754 QLEQQL--QGLHRKVGETSLLLSQREQEIVVLQQQLQ--------EAREQGELKEQSLQS 1803

Query: 628  RLKVLHAQILEKDAVIKVLQQRSRRDPGK---------AIQGSLRPA 665
            +L      + ++D  ++ LQQ  ++  G+         A+QG+L  A
Sbjct: 1804 QLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQA 1850



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 61/260 (23%), Positives = 108/260 (41%), Gaps = 49/260 (18%)

Query: 299  AQASSA--------TSGSAHLAQMEAVLRENARLQRDNER----------LQREL----E 336
            AQAS+A        T+ SA   + E V  E  R Q   E+          LQ  L    +
Sbjct: 1369 AQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQ 1428

Query: 337  SSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRN-KMDSEMRRLQDFNRDLR 395
            + AE+   +E L  +IQ L +  E + +A+ +  +L+   RN ++D +  ++Q+      
Sbjct: 1429 TLAEREEEVETLRGQIQELEKQRE-MQKAALELLSLDLKKRNQEVDLQQEQIQEL----- 1482

Query: 396  ERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQ-EKLEREMALLRGAIEDQRRR 454
            E+  S    L    QE +            Q    Q+EQ  +LE++    R  +E Q   
Sbjct: 1483 EKCRSVLEHLPMAVQERE------------QKLTVQREQIRELEKDRETQRNVLEHQLLE 1530

Query: 455  AELLEQALGNAQGRAARAEEELRKKQAYV-------EKVERLQQALGQLQAACEKREQLE 507
             E  +Q + + +G+    +++L   +           K+E  Q+ + +L+   E +    
Sbjct: 1531 LEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVAL 1590

Query: 508  LRLRTRLEQELKALRAQQRQ 527
              L   LE+  + L+AQ  Q
Sbjct: 1591 THLTLDLEERSQELQAQSSQ 1610



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 58/274 (21%), Positives = 116/274 (42%), Gaps = 34/274 (12%)

Query: 312 AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREA 371
           AQ+  +L +   L+++     +EL    +  G +EK E +  R++E    LT++  + E 
Sbjct: 244 AQLLLLLAKTQELEKEAHERSQEL-IQLKSQGDLEKAELQ-DRVTELSALLTQSQKQNED 301

Query: 372 LEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQ 431
            EK ++   ++ +  L+  + +L E   S +R    +    Q   +D+   ++ +     
Sbjct: 302 YEKMIKALRET-VEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIA 360

Query: 432 Q---EQEKLEREMALL-RGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVE 487
           Q    +  LE + ++  +   +D  +   L+   L              R++QA    V+
Sbjct: 361 QGSGHENSLELDSSIFSQFDYQDADKALTLVRSVL-------------TRRRQA----VQ 403

Query: 488 RLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQ-QRQAGAPGGSSGSGGSPELSAL 546
            L+Q L    A C++   L  +   + E+E KALR + Q+  G     +G     +    
Sbjct: 404 DLRQQL----AGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVD 459

Query: 547 RLSEQLREKEEQILALEADMTKWEQKYLEERAMR 580
            LS     KE ++L    +  + + + LE+ A R
Sbjct: 460 SLS-----KERELLQKAREELRQQLEVLEQEAWR 488



 Score = 30.8 bits (68), Expect = 5.0
 Identities = 31/118 (26%), Positives = 54/118 (45%), Gaps = 12/118 (10%)

Query: 399 ESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELL 458
           ++A+ R    +QEAQ     +V KL A+  + +   ++LE+ +    G I    +R E +
Sbjct: 35  QAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIP---QRWENV 91

Query: 459 EQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQ 516
           E+   N      R EEE        ++ E L +   QL+   EK + +   LR  +E+
Sbjct: 92  EEP--NLDELLVRLEEE-------QQRCESLAEVNTQLRLHMEKADVVNKALREDVEK 140


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 75/324 (23%), Positives = 138/324 (42%), Gaps = 34/324 (10%)

Query: 294  EGPVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQ 353
            E  ++ Q S          Q++  L+EN   Q   E L+ ELE+      ++EKL S++ 
Sbjct: 1086 EFDINQQNSKIEDEQVLALQLQKKLKEN---QARIEELEEELEAERTARAKVEKLRSDLS 1142

Query: 354  R-LSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEA 412
            R L E  E L  A     +++  M  K ++E ++       +R  LE A  +  +     
Sbjct: 1143 RELEEISERLEEAGG-ATSVQIEMNKKREAEFQK-------MRRDLEEATLQHEATAAAL 1194

Query: 413  QAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARA 472
            +    D VA+L  Q    Q+ ++KLE+E +  +  ++D     E + +A  N +  +   
Sbjct: 1195 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTL 1254

Query: 473  EEELRKKQAYVEKVER-----------LQQALGQLQAACEKREQLELRL---RTRLEQEL 518
            E++  + +  +E+ +R           LQ   G+L    E++E L  +L   +    Q++
Sbjct: 1255 EDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQM 1314

Query: 519  KALRAQQRQAG-APGGSSGSGGSPELSALRLSEQLREKEEQILALE-------ADMTKWE 570
            + L+ Q  + G A    + +  S       L EQ  E+ E    L+       +++ +W 
Sbjct: 1315 EDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWR 1374

Query: 571  QKYLEERAMRQFAMDAAATAAAQR 594
             KY  +   R   ++ A    AQR
Sbjct: 1375 TKYETDAIQRTEELEEAKKKLAQR 1398



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 79/399 (19%), Positives = 157/399 (39%), Gaps = 45/399 (11%)

Query: 294  EGPVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQ 353
            E  +  +A++A     H   +  +  +   LQR  ++L++E    +E    ++ + S ++
Sbjct: 1182 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE---KSEFKLELDDVTSNME 1238

Query: 354  RLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQ 413
            ++ +A  +L + S   E      R K++   R L DF    R +L++ N  LA + +E +
Sbjct: 1239 QIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQ-RAKLQTENGELARQLEEKE 1297

Query: 414  AGSQDMVAKLLAQSYEQQQEQEKLERE-----------------MALLRGAIEDQRRRAE 456
            A    +    L+ + + +  + +LE E                   LLR   E++     
Sbjct: 1298 ALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKA 1357

Query: 457  LLEQALGNAQGRAA------------RAEEELRKKQAYVEKVERLQQALGQLQAACEKRE 504
             L++ L  A    A            R EE    K+   ++++  ++A+  + A C   E
Sbjct: 1358 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLE 1417

Query: 505  QLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEA 564
            + + RL+  +E  +  +  ++  A A           ++    L+E  ++ EE    LE+
Sbjct: 1418 KTKHRLQNEIEDLM--VDVERSNAAAAALDKKQRNFDKI----LAEWKQKYEESQSELES 1471

Query: 565  DMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPS-SSFNEGLLTGGHRHQ 623
                  QK     +   F +  A   + +   T  R +       S   E L  GG    
Sbjct: 1472 S-----QKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVH 1526

Query: 624  EMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQGSL 662
            E+E   K L  + LE  + ++  +     + GK ++  L
Sbjct: 1527 ELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQL 1565



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 69/291 (23%), Positives = 130/291 (44%), Gaps = 32/291 (10%)

Query: 322  ARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMD 381
            A+++  NERL+ E E +AE   +  KLE E   L +  + L    +K E  +    NK+ 
Sbjct: 919  AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV- 977

Query: 382  SEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQ------QQEQE 435
                      ++L E +   +  +A  T+E +A  +     L     E+       + + 
Sbjct: 978  ----------KNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKV 1027

Query: 436  KLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEEL----RKKQAYVEKVERLQQ 491
            KLE+++  L G++E +++    LE+A    +G     +E +      K    EK+++ + 
Sbjct: 1028 KLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEF 1087

Query: 492  ALGQLQAACEKREQLELRLRTRLE------QELKALRAQQRQAGAPGGSSGSGGSPELSA 545
             + Q  +  E  + L L+L+ +L+      +EL+     +R A A      S  S EL  
Sbjct: 1088 DINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELE- 1146

Query: 546  LRLSEQLREKEEQILALEADMTKWEQKYLEE--RAMRQFAMDAAATAAAQR 594
              +SE+L E+     +++ +M K  +   ++  R + +  +   ATAAA R
Sbjct: 1147 -EISERL-EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR 1195



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 73/305 (23%), Positives = 132/305 (43%), Gaps = 26/305 (8%)

Query: 302  SSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRL-SEAHE 360
            S  TS  A       VLR   +++ D   ++ +L  +   A   +K    +Q L  +   
Sbjct: 1598 SLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQI 1657

Query: 361  SLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMV 420
             L  A    + L++ +   ++     LQ    +LR  +E   R      QE    S+  V
Sbjct: 1658 QLDDAVRANDDLKENIAI-VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE-RV 1715

Query: 421  AKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQ 480
              L +Q+     +++K+E ++  L+  +E+  +     E+    A   AA   EEL+K+Q
Sbjct: 1716 QLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ 1775

Query: 481  ---AYVEKVER-LQQALGQLQAACEKREQ------------LELRLRTRLEQELKALRAQ 524
               A++E++++ ++Q +  LQ   ++ EQ            LE R+R  LE EL+A   Q
Sbjct: 1776 DTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVR-ELEGELEA--EQ 1832

Query: 525  QRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAM 584
            +R A +  G   S    E     L+ Q  E ++ +L L+  + K + K    +   + A 
Sbjct: 1833 KRNAESVKGMRKS----ERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAE 1888

Query: 585  DAAAT 589
            + A T
Sbjct: 1889 EQANT 1893



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 52/222 (23%), Positives = 97/222 (43%), Gaps = 21/222 (9%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQ--------RLSEAHESL 362
            L  +E   REN  LQ +   L  +L    +    +EK+  +++         L EA  SL
Sbjct: 1494 LEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASL 1553

Query: 363  TRASSK--REALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMV 420
                 K  R  LE    N++ +E+ R      +  E+ +  ++R+    Q +        
Sbjct: 1554 EHEEGKILRAQLE---FNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSR 1610

Query: 421  AKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQ---GRAARAEEELR 477
             ++L    + + +  ++E +++       + +++ + L+  L + Q     A RA ++L+
Sbjct: 1611 NEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK 1670

Query: 478  KKQAYVEKVERLQQA-LGQLQAACEKREQLELRLRTRLEQEL 518
            +  A VE+   L QA L +L+A  E+ E    R R   EQEL
Sbjct: 1671 ENIAIVERRNNLLQAELEELRAVVEQTE----RSRKLAEQEL 1708



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 37/169 (21%), Positives = 77/169 (45%), Gaps = 9/169 (5%)

Query: 322  ARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMD 381
            A  ++  E  Q ELESS ++A     L +E+ +L  A+E         +   K ++ ++ 
Sbjct: 1456 AEWKQKYEESQSELESSQKEA---RSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS 1512

Query: 382  SEMRRLQDFNRDL------RERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQE 435
                +L +  +++      R++LE     L S  +EA+A  +    K+L    E  Q + 
Sbjct: 1513 DLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1572

Query: 436  KLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVE 484
            ++ER++A     +E  +R  + +  +L  +     R+  E+ + +  +E
Sbjct: 1573 EIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKME 1621



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 48/245 (19%), Positives = 108/245 (44%), Gaps = 57/245 (23%)

Query: 314  MEAVLRENARLQRDNERLQRELESS-------------------------AEKAGRIEKL 348
            +EAV  + + L++   RLQ E+E                           AE   + E+ 
Sbjct: 1406 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1465

Query: 349  ESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASK 408
            +SE++   +   SL+    K       ++N  +  +  L+ F R+ +   E     ++  
Sbjct: 1466 QSELESSQKEARSLSTELFK-------LKNAYEESLEHLETFKRENKNLQE----EISDL 1514

Query: 409  TQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGR 468
            T++   G +++        +E ++ +++LE E   L+ A+E+        E +L + +G+
Sbjct: 1515 TEQLGEGGKNV--------HELEKVRKQLEVEKLELQSALEE-------AEASLEHEEGK 1559

Query: 469  AARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKA----LRAQ 524
              RA+ E  + +A +E+  +L +   +++ A    +++   L+T L+ E ++    LR +
Sbjct: 1560 ILRAQLEFNQIKAEIER--KLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVK 1617

Query: 525  QRQAG 529
            ++  G
Sbjct: 1618 KKMEG 1622


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 71/306 (23%), Positives = 134/306 (43%), Gaps = 34/306 (11%)

Query: 312  AQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQR-LSEAHESLTRASSKRE 370
            +Q++  L+E   LQ   E L+ ELE+      ++EKL S++ R L E  E L  A     
Sbjct: 1102 SQLQKKLKE---LQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT- 1157

Query: 371  ALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQ 430
            +++  M  K ++E +++       R  LE A  +  +     +    D VA+L  Q    
Sbjct: 1158 SVQIEMNKKREAEFQKM-------RRDLEEATLQHEATAAALRKKHADSVAELGEQIDNL 1210

Query: 431  QQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVER-- 488
            Q+ ++KLE+E +  +  ++D     E + +A  N +      E+++ + ++  E+ +R  
Sbjct: 1211 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSV 1270

Query: 489  ---------LQQALGQLQAACEKREQLELRL---RTRLEQELKALRAQ-QRQAGAPGGSS 535
                     LQ   G+L    +++E L  +L   +    Q+L+ L+ Q + +  A    +
Sbjct: 1271 NDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALA 1330

Query: 536  GSGGSPELSALRLSEQLREKEEQILALE-------ADMTKWEQKYLEERAMRQFAMDAAA 588
             +  S       L EQ  E+ E    L+       +++ +W  KY  +   R   ++ A 
Sbjct: 1331 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 1390

Query: 589  TAAAQR 594
               AQR
Sbjct: 1391 KKLAQR 1396



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 71/291 (24%), Positives = 130/291 (44%), Gaps = 32/291 (10%)

Query: 322  ARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMD 381
            A+++  NERL+ E E +AE   +  KLE E   L    + L    +K E  +    NK+ 
Sbjct: 917  AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKV- 975

Query: 382  SEMRRLQDFNRDLRERLESANRRLASKTQEAQA---GSQDMVAKLLAQSYEQQ---QEQE 435
                      ++L E +   +  +A  T+E +A     Q  +  L A+  +     + + 
Sbjct: 976  ----------KNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV 1025

Query: 436  KLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEEL----RKKQAYVEKVERLQQ 491
            KLE+++  L G++E +++    LE+A    +G     +E +      KQ   E++++   
Sbjct: 1026 KLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDF 1085

Query: 492  ALGQLQAACEKREQLELRLRTRLE------QELKALRAQQRQAGAPGGSSGSGGSPELSA 545
             L  L A  E  + L  +L+ +L+      +EL+     +R A A      S  S EL  
Sbjct: 1086 ELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELE- 1144

Query: 546  LRLSEQLREKEEQILALEADMTKWEQKYLEE--RAMRQFAMDAAATAAAQR 594
              +SE+L E+     +++ +M K  +   ++  R + +  +   ATAAA R
Sbjct: 1145 -EISERL-EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR 1193



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 89/374 (23%), Positives = 149/374 (39%), Gaps = 53/374 (14%)

Query: 313  QMEAVLRENARLQR-----DNERLQRELESSAEKAGRIEKLESE----IQRLSEAHESLT 363
            Q E      A LQR     ++E  Q   +   +   R E+LE       QRL EA E++ 
Sbjct: 1346 QYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVE 1405

Query: 364  RASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKL 423
              ++K  +LEKT          RLQ+   DL   +E +N   A+  ++ +  + D +   
Sbjct: 1406 AVNAKCSSLEKT--------KHRLQNEIEDLMVDVERSNAAAAALDKKQR--NFDKILAE 1455

Query: 424  LAQSYEQ--------QQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQ--------- 466
              Q YE+        Q+E   L  E+  L+ A E+     E  ++   N Q         
Sbjct: 1456 WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1515

Query: 467  -GRAARAEEELRK--KQAYVEKVERLQQALGQLQAACEKRE------QLEL-RLRTRLEQ 516
             G + +   EL K  KQ   EK+E LQ AL + +A+ E  E      QLE  +++  +E+
Sbjct: 1516 LGSSGKTIHELEKVRKQLEAEKME-LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIER 1574

Query: 517  ELKALRAQQRQAGAPGGSSGSGGSPELSALRLS--EQLREKEEQILALEADMTKWEQKYL 574
            +L     +  QA              L A   S  E LR K++    +E D+ + E +  
Sbjct: 1575 KLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKK----MEGDLNEMEIQLS 1630

Query: 575  EERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHA 634
                M   A     +  +    T I+       +    E +     R+  +++ L+ L A
Sbjct: 1631 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1690

Query: 635  QILEKDAVIKVLQQ 648
             + + +   K+ +Q
Sbjct: 1691 VVEQTERSRKLAEQ 1704



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 63/276 (22%), Positives = 122/276 (44%), Gaps = 40/276 (14%)

Query: 322  ARLQRDNERLQRELESSAEKAGRIE----KLESEIQRLSEAHES----LTRASSKREALE 373
            A+++++    + ++++  E+   ++    KL  E + L EAH+     L     K   L 
Sbjct: 962  AKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLT 1021

Query: 374  KTMRNKMDSEMRRLQ---DFNRDLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQ 430
            K  + K++ ++  L+   +  + +R  LE A R+L    +  Q    D+         ++
Sbjct: 1022 KA-KVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL-------ENDK 1073

Query: 431  QQEQEKLER---EMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVE 487
            QQ  E+L++   E+  L   IED++     L++ L   Q R    EEEL  ++    KVE
Sbjct: 1074 QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVE 1133

Query: 488  RLQQALG-QLQAACEKREQ------LELRLRTRLEQELKALRAQ------QRQAGAPG-- 532
            +L+  L  +L+   E+ E+      +++ +  + E E + +R        Q +A A    
Sbjct: 1134 KLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR 1193

Query: 533  ---GSSGSGGSPELSALRLSEQLREKEEQILALEAD 565
                 S +    ++  L+  +Q  EKE+    LE D
Sbjct: 1194 KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELD 1229



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 79/325 (24%), Positives = 150/325 (46%), Gaps = 63/325 (19%)

Query: 313  QMEAVLRENARLQRDNERLQRELES---SAEKAGRIEKL------ESEIQRLSEAHESLT 363
            +ME   R + R+    + LQ  L++   S  +A R++K       E EIQ LS A+    
Sbjct: 1582 EMEQAKRNHLRVV---DSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQ-LSHANRMAA 1637

Query: 364  RASSKREALEKTMRN---KMDSEMRRLQDFNRDLRERLESANRR---LASKTQEAQA--- 414
             A  + ++L+  +++   ++D  +R     N DL+E +    RR   L ++ +E +A   
Sbjct: 1638 EAQKQVKSLQSLLKDTQIQLDDAVRA----NDDLKENIAIVERRNNLLQAELEELRAVVE 1693

Query: 415  ---GSQDMVAKLLAQSYEQQQ-----------EQEKLEREMALLRGAIEDQRRRAELLEQ 460
                S+ +  + L ++ E+ Q           +++K++ +++ L+  +E+  +     E+
Sbjct: 1694 QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEE 1753

Query: 461  ALGNAQGRAARAEEELRKKQ---AYVEKVER-LQQALGQLQAACEKREQ----------- 505
                A   AA   EEL+K+Q   A++E++++ ++Q +  LQ   ++ EQ           
Sbjct: 1754 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQ 1813

Query: 506  -LELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEA 564
             LE R+R  LE EL+A   Q+R A +  G   S    E     L+ Q  E  + +L L+ 
Sbjct: 1814 KLEARVR-ELENELEA--EQKRNAESVKGMRKS----ERRIKELTYQTEEDRKNLLRLQD 1866

Query: 565  DMTKWEQKYLEERAMRQFAMDAAAT 589
             + K + K    +   + A + A T
Sbjct: 1867 LVDKLQLKVKAYKRQAEEAEEQANT 1891



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 54/222 (24%), Positives = 97/222 (43%), Gaps = 21/222 (9%)

Query: 311  LAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQ--------RLSEAHESL 362
            L  +E   REN  LQ +   L  +L SS +    +EK+  +++         L EA  SL
Sbjct: 1492 LEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASL 1551

Query: 363  TRASSK--REALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMV 420
                 K  R  LE    N++ +E+ R      +  E+ +  + R+    Q +        
Sbjct: 1552 EHEEGKILRAQLE---FNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSR 1608

Query: 421  AKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQ---GRAARAEEELR 477
             + L    + + +  ++E +++       + +++ + L+  L + Q     A RA ++L+
Sbjct: 1609 NEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK 1668

Query: 478  KKQAYVEKVERLQQA-LGQLQAACEKREQLELRLRTRLEQEL 518
            +  A VE+   L QA L +L+A  E+ E    R R   EQEL
Sbjct: 1669 ENIAIVERRNNLLQAELEELRAVVEQTE----RSRKLAEQEL 1706



 Score = 31.2 bits (69), Expect = 3.9
 Identities = 33/169 (19%), Positives = 75/169 (44%), Gaps = 25/169 (14%)

Query: 422 KLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQA 481
           K L +S E+++E   ++ E   L+ A+E    R + LE+ + +           L++K  
Sbjct: 837 KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSL----------LQEKND 886

Query: 482 YVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGSP 541
              +V+  Q  L   +  C++  + +++L  ++++  + L  ++              + 
Sbjct: 887 LQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEM------------NA 934

Query: 542 ELSA--LRLSEQLREKEEQILALEADMTKWE-QKYLEERAMRQFAMDAA 587
           EL+A   +L ++  E +  I  LE  + K E +K+  E  ++    + A
Sbjct: 935 ELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMA 983


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.125    0.343 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,067,860
Number of Sequences: 37866
Number of extensions: 1820070
Number of successful extensions: 20212
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 321
Number of HSP's successfully gapped in prelim test: 1324
Number of HSP's that attempted gapping in prelim test: 11960
Number of HSP's gapped (non-prelim): 6070
length of query: 780
length of database: 18,247,518
effective HSP length: 110
effective length of query: 670
effective length of database: 14,082,258
effective search space: 9435112860
effective search space used: 9435112860
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.