Search of human proteins with 32483357

Search of human proteins with 32483357

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
         (278 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...   543   e-155
gi|126723750 dehydrogenase/reductase (SDR family) member 4 like ...   438   e-123
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ...   374   e-104
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi...   320   7e-88
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap...   270   1e-72
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]    115   4e-26
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]             114   1e-25
gi|40254992 carbonic reductase 4 [Homo sapiens]                       112   3e-25
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]          110   2e-24
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]    104   1e-22
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...    97   1e-20
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]        91   1e-18
gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]                 89   3e-18
gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]        88   7e-18
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]      84   1e-16
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]       84   1e-16
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    83   2e-16
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]     81   9e-16
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...    80   3e-15
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...    79   4e-15
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]         78   7e-15
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]          77   1e-14
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo...    75   8e-14
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi...    74   1e-13
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]    73   3e-13
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [...    71   9e-13
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]           69   3e-12
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ...    68   8e-12
gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]            67   2e-11
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...    67   2e-11

>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score =  543 bits (1399), Expect = e-155
 Identities = 278/278 (100%), Positives = 278/278 (100%)

Query: 1   MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVV 60
           MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVV
Sbjct: 1   MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVV 60

Query: 61  VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVN 120
           VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVN
Sbjct: 61  VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVN 120

Query: 121 PFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFS 180
           PFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFS
Sbjct: 121 PFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFS 180

Query: 181 PYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIR 240
           PYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIR
Sbjct: 181 PYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIR 240

Query: 241 RLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL 278
           RLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL
Sbjct: 241 RLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL 278


>gi|126723750 dehydrogenase/reductase (SDR family) member 4 like 1
           [Homo sapiens]
          Length = 281

 Score =  438 bits (1127), Expect = e-123
 Identities = 228/281 (81%), Positives = 247/281 (87%), Gaps = 3/281 (1%)

Query: 1   MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVV 60
           MHKA L G CARA  SVR+ASSGMTRRDPL NKVALVTASTD IGFA+A+RLAQDGAHVV
Sbjct: 1   MHKARLRGHCARAGKSVRLASSGMTRRDPLTNKVALVTASTDWIGFAVAQRLAQDGAHVV 60

Query: 61  VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDIL---VSNA 117
           VS RKQQNVDQAVATLQGEGLS+TGTVCHVGK +D ERLVATA+KLHG IDIL   ++N+
Sbjct: 61  VSRRKQQNVDQAVATLQGEGLSMTGTVCHVGKMKDWERLVATAMKLHGVIDILSLSITNS 120

Query: 118 AVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSP 177
               F+ +++   EE WD+ LDIN KA ALM KAVVPEMEKRGGGSV  ++S+AAF P P
Sbjct: 121 KRGLFWFTLLQTAEEAWDRNLDINGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLP 180

Query: 178 GFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETL 237
           GFSPYNVSKTALLGL KTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETL
Sbjct: 181 GFSPYNVSKTALLGLNKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETL 240

Query: 238 RIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL 278
           RIRRLGEPED  GIVSFLCSEDASY+TGETV+VGGGTPSRL
Sbjct: 241 RIRRLGEPEDSLGIVSFLCSEDASYLTGETVMVGGGTPSRL 281


>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
           [Homo sapiens]
          Length = 232

 Score =  374 bits (961), Expect = e-104
 Identities = 197/210 (93%), Positives = 198/210 (94%)

Query: 1   MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVV 60
           M  A LLGLCA A  SVRMASS MTRRDPL NKVALVTASTDGIGFAIARRLAQD AHVV
Sbjct: 1   MQMARLLGLCAWARKSVRMASSRMTRRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVV 60

Query: 61  VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVN 120
           VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVA AVKLHGGIDILVSNAAVN
Sbjct: 61  VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVN 120

Query: 121 PFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFS 180
           PFFGS+MDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFS
Sbjct: 121 PFFGSLMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFS 180

Query: 181 PYNVSKTALLGLTKTLAIELAPRNIRVNCL 210
           PYNVSKTALLGL  TLAIELAPRNIRVNCL
Sbjct: 181 PYNVSKTALLGLNNTLAIELAPRNIRVNCL 210


>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
           sapiens]
          Length = 280

 Score =  320 bits (821), Expect = 7e-88
 Identities = 162/263 (61%), Positives = 209/263 (79%), Gaps = 3/263 (1%)

Query: 10  CARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNV 69
           CAR   SVRM+S+G+ R+  LAN+VA+VT ST GIGFAIARRLA+DGAHVV+SSRKQQNV
Sbjct: 16  CARL--SVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNV 73

Query: 70  DQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDV 129
           D+A+A LQGEGLSV G VCHVGKAEDRE+LVA A++  GG+D LV +A VNP  GS +  
Sbjct: 74  DRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGT 133

Query: 130 TEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTAL 189
           +E++WDK L +NVK+PAL+   ++P ME R  G+V++VSSIAA++P      YNVSKTAL
Sbjct: 134 SEQIWDKILSVNVKSPALLLSQLLPYMENR-RGAVILVSSIAAYNPVVALGVYNVSKTAL 192

Query: 190 LGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCA 249
           LGLT+TLA+ELAP++IRVNC+ PG+IKT FS++   ++   ++ KE  +++R+GE EDCA
Sbjct: 193 LGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESEDCA 252

Query: 250 GIVSFLCSEDASYITGETVVVGG 272
           GIVSFLCS DASY+ GE + V G
Sbjct: 253 GIVSFLCSPDASYVNGENIAVAG 275


>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
           sapiens]
          Length = 300

 Score =  270 bits (690), Expect = 1e-72
 Identities = 137/214 (64%), Positives = 175/214 (81%), Gaps = 3/214 (1%)

Query: 10  CARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNV 69
           CAR   SVRM+S+G+ R+  LAN+VA+VT ST GIGFAIARRLA+DGAHVV+SSRKQQNV
Sbjct: 16  CARL--SVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNV 73

Query: 70  DQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDV 129
           D+A+A LQGEGLSV G VCHVGKAEDRE+LVA A++  GG+D LV +A VNP  GS +  
Sbjct: 74  DRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGT 133

Query: 130 TEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTAL 189
           +E++WDK L +NVK+PAL+   ++P ME R  G+V++VSSIAA++P      YNVSKTAL
Sbjct: 134 SEQIWDKILSVNVKSPALLLSQLLPYMENR-RGAVILVSSIAAYNPVVALGVYNVSKTAL 192

Query: 190 LGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRML 223
           LGLT+TLA+ELAP++IRVNC+ PG+IKT FS+++
Sbjct: 193 LGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVV 226


>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
          Length = 303

 Score =  115 bits (288), Expect = 4e-26
 Identities = 82/253 (32%), Positives = 128/253 (50%), Gaps = 13/253 (5%)

Query: 30  LANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQG-----EGLSVT 84
           L  +VA+VT    GIG AI + L + G++VV++SRK + +  A   LQ      +   V 
Sbjct: 16  LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75

Query: 85  GTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKA 144
              C++   E+   LV + +   G I+ LV+N     F      ++ + W   L+ N+  
Sbjct: 76  PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGG-GQFLSPAEHISSKGWHAVLETNLTG 134

Query: 145 PALMTKAVVPEMEKRGGGSVV--IVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAP 202
              M KAV     K  GGS+V  IV + A F   P       ++  +  LTK+LA+E A 
Sbjct: 135 TFYMCKAVYSSWMKEHGGSIVNIIVPTKAGF---PLAVHSGAARAGVYNLTKSLALEWAC 191

Query: 203 RNIRVNCLAPGLI--KTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDA 260
             IR+NC+APG+I  +T+        +   E   + +  +R+G PE+ + +V FL S  A
Sbjct: 192 SGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSPAA 251

Query: 261 SYITGETVVVGGG 273
           S+ITG++V V GG
Sbjct: 252 SFITGQSVDVDGG 264


>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
          Length = 244

 Score =  114 bits (284), Expect = 1e-25
 Identities = 79/245 (32%), Positives = 124/245 (50%), Gaps = 10/245 (4%)

Query: 30  LANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCH 89
           LA +  LVT +  GIG    + L   GA VV  SR Q ++D  V    G    +      
Sbjct: 5   LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVCVD 60

Query: 90  VGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMT 149
           +G  E  ER + +     G +D+LV+NAAV       ++VT+E +D++ ++N++A   ++
Sbjct: 61  LGDWEATERALGSV----GPVDLLVNNAAV-ALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115

Query: 150 KAVVPEMEKRG-GGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVN 208
           + V   +  RG  G++V VSS  +       S Y  +K AL  LTK +A+EL P  IRVN
Sbjct: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175

Query: 209 CLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETV 268
            + P ++ TS  +  W D  K ++M   + + +  E E     + FL S+ +   TG T+
Sbjct: 176 AVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235

Query: 269 VVGGG 273
            V GG
Sbjct: 236 PVEGG 240


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score =  112 bits (281), Expect = 3e-25
 Identities = 80/242 (33%), Positives = 125/242 (51%), Gaps = 11/242 (4%)

Query: 32  NKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVG 91
           +KV  V   + GIG A+A+ +A+ G  + V +R  +    A   L G+ L+ +   C V 
Sbjct: 2   DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFS---CDVA 58

Query: 92  KAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKA 151
           K  D +       K  G ++ LV+ A +N     +   TE++  + L  N+    L  KA
Sbjct: 59  KEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQ-LHTNLLGSMLTCKA 117

Query: 152 VVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLA 211
            +  M ++ GGS+V V SI     + G S Y+ SK  L+G ++ LA E+A + IRVN +A
Sbjct: 118 AMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVA 177

Query: 212 PGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVG 271
           PG + T  ++ L     KEE +K+ + + R GE  + A  V FL   ++ YITG  +VV 
Sbjct: 178 PGFVHTDMTKDL-----KEEHLKKNIPLGRFGETIEVAHAVVFLL--ESPYITGHVLVVD 230

Query: 272 GG 273
           GG
Sbjct: 231 GG 232


>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
          Length = 261

 Score =  110 bits (274), Expect = 2e-24
 Identities = 78/252 (30%), Positives = 124/252 (49%), Gaps = 10/252 (3%)

Query: 30  LANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSV------ 83
           L + +ALVT +  GIG A++ RLA +GA V      +    + V  L G G         
Sbjct: 9   LRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGN 68

Query: 84  -TGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINV 142
                  V +A     L+            +V + A       ++ ++E+ WDK + +N+
Sbjct: 69  HAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNL 128

Query: 143 KAPALMTKAVVPEMEKRG-GGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELA 201
           K   L+T+A    +   G  GS++ +SSI     + G + Y  SK  ++GLT+T A EL 
Sbjct: 129 KGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELG 188

Query: 202 PRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDAS 261
              IR N + PG I T  ++ +   ++  + + E + +  LG+PED A +V+FL SED+ 
Sbjct: 189 RHGIRCNSVLPGFIATPMTQKV--PQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSG 246

Query: 262 YITGETVVVGGG 273
           YITG +V V GG
Sbjct: 247 YITGTSVEVTGG 258


>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
          Length = 245

 Score =  104 bits (259), Expect = 1e-22
 Identities = 73/251 (29%), Positives = 131/251 (52%), Gaps = 19/251 (7%)

Query: 30  LANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQA--VATLQGEGLSVTGTV 87
           L  KV ++TA+  GIG A A   A++GA V+ +   +  + +      +Q   L VT   
Sbjct: 4   LDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVTKKK 63

Query: 88  CHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPAL 147
                A + ERL           D+L  N A     G+++D  E+ WD ++++NV++  L
Sbjct: 64  QIDQFANEVERL-----------DVLF-NVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYL 111

Query: 148 MTKAVVPEMEKRGGGSVVIVSSIA-AFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIR 206
           M KA +P+M  +  G+++ +SS+A +         Y+ +K A++GLTK++A +   + IR
Sbjct: 112 MIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIR 171

Query: 207 VNCLAPGLIKT-SFSRMLWMDKEKEESMKETLRIRRLGE---PEDCAGIVSFLCSEDASY 262
            NC+ PG + T S    +      EE+  + L+ ++ G     E+ A +  +L S++++Y
Sbjct: 172 CNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAY 231

Query: 263 ITGETVVVGGG 273
           +TG  V++ GG
Sbjct: 232 VTGNPVIIDGG 242


>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score = 97.4 bits (241), Expect = 1e-20
 Identities = 68/247 (27%), Positives = 122/247 (49%), Gaps = 10/247 (4%)

Query: 31  ANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHV 90
           A KV +VT    GIG  I R     GA VV+  + +         L G        +C V
Sbjct: 8   AGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPG----AVFILCDV 63

Query: 91  GKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTK 150
            + +D + LV+  ++  G +D +V+NA  +P      + + + + + L++N+     +TK
Sbjct: 64  TQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTK 123

Query: 151 AVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCL 210
             +P + K  G  + I S + A   +    PY  +K A+  +TK LA++ +P  +RVNC+
Sbjct: 124 LALPYLRKSQGNVINISSLVGAIGQAQAV-PYVATKGAVTAMTKALALDESPYGVRVNCI 182

Query: 211 APGLIKTS-FSRMLWMDKEKEESMKETL---RIRRLGEPEDCAGIVSFLCSEDASYITGE 266
           +PG I T  +  +  +  +   +++E +    + R+G+P +      FL SE A++ TG 
Sbjct: 183 SPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASE-ANFCTGI 241

Query: 267 TVVVGGG 273
            ++V GG
Sbjct: 242 ELLVTGG 248


>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
          Length = 260

 Score = 90.5 bits (223), Expect = 1e-18
 Identities = 75/259 (28%), Positives = 132/259 (50%), Gaps = 20/259 (7%)

Query: 19  MASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQG 78
           MA  GM R     +++ALVT ++ GIG A+AR L Q G  VV  +R   N+++  A  + 
Sbjct: 1   MARPGMER---WRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKS 57

Query: 79  EGLSVTGTV----CHVGKAEDRERLVATAVKLHGGIDILVSNAAV-NPFFGSIMDVTEEV 133
            G    GT+    C +   ED   + +     H G+DI ++NA +  P   +++  +   
Sbjct: 58  AG--YPGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARP--DTLLSGSTSG 113

Query: 134 WDKTLDINVKAPALMTKAVVPEMEKRG--GGSVVIVSSIAAFS--PSPGFSPYNVSKTAL 189
           W    ++NV A ++ T+     M++R    G ++ ++S++     P      Y+ +K A+
Sbjct: 114 WKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAV 173

Query: 190 LGLTKTLAIEL--APRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPED 247
             LT+ L  EL  A  +IR  C++PG+++T F+  L  DK+ E++     +++ L +PED
Sbjct: 174 TALTEGLRQELREAQTHIRATCISPGVVETQFAFKL-HDKDPEKAAATYEQMKCL-KPED 231

Query: 248 CAGIVSFLCSEDASYITGE 266
            A  V ++ S  A    G+
Sbjct: 232 VAEAVIYVLSTPAHIQIGD 250


>gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]
          Length = 292

 Score = 89.4 bits (220), Expect = 3e-18
 Identities = 77/252 (30%), Positives = 115/252 (45%), Gaps = 11/252 (4%)

Query: 28  DPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTV 87
           D L +KVA +T    GIGF IA    + G H V++SR    V  A   L G     TG  
Sbjct: 24  DLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAG----ATGRR 79

Query: 88  CHVGKAEDRE-----RLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINV 142
           C     + R        V  A+K  G IDIL++ AA N F      ++   +   +DI+ 
Sbjct: 80  CLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGN-FLCPAGALSFNAFKTVMDIDT 138

Query: 143 KAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAP 202
                +++ +  +  +  GG +V +++               +K A+  +T+ LA+E  P
Sbjct: 139 SGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGP 198

Query: 203 RNIRVNCLAPGLIK-TSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDAS 261
           +NIRVN LAPG I  T   R L   +    +      ++RLG   + A  V +L S  AS
Sbjct: 199 QNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLAS 258

Query: 262 YITGETVVVGGG 273
           Y+TG  +V  GG
Sbjct: 259 YVTGAVLVADGG 270


>gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
          Length = 335

 Score = 88.2 bits (217), Expect = 7e-18
 Identities = 70/245 (28%), Positives = 118/245 (48%), Gaps = 6/245 (2%)

Query: 33  KVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGE-GLSVTGTVCHVG 91
           KVA +T    G+G  +   L+  GA  V++SRK   +      +  + G  V    C V 
Sbjct: 60  KVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVR 119

Query: 92  KAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKA 151
             +  +  V+  +K+ G  +I+++NAA N F      ++   W    DI +   A +T  
Sbjct: 120 DPDMVQNTVSELIKVAGHPNIVINNAAGN-FISPTERLSPNAWKTITDIVLNGTAFVTLE 178

Query: 152 VVPEMEK-RGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCL 210
           +  ++ K + G + + +++I A + S    P   +K  +  ++K+LA E     +R N +
Sbjct: 179 IGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVI 238

Query: 211 APGLIKT--SFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETV 268
            PG IKT  +FSR L      E+ M   +   RLG  E+ A + +FLCS+ AS+I G  +
Sbjct: 239 QPGPIKTKGAFSR-LDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVI 297

Query: 269 VVGGG 273
              GG
Sbjct: 298 KFDGG 302


>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 84.0 bits (206), Expect = 1e-16
 Identities = 64/197 (32%), Positives = 103/197 (52%), Gaps = 9/197 (4%)

Query: 26  RRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTG 85
           R + L  K  +VT ++ GIG  +A  LA+ GAHVVV++R ++ + + V+     G +   
Sbjct: 28  RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAH 87

Query: 86  TVCHVGKAED---RERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINV 142
            +   G  ED    E+ VA A KL GG+D+L+ N   N       D    V  K++++N 
Sbjct: 88  YI--AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHV-RKSMEVNF 144

Query: 143 KAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIE--L 200
            +  ++T A +P M K+  GS+V+VSS+A     P  + Y+ SK AL G   ++  E  +
Sbjct: 145 LSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV 203

Query: 201 APRNIRVNCLAPGLIKT 217
           +  N+ +     GLI T
Sbjct: 204 SRVNVSITLCVLGLIDT 220


>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 84.0 bits (206), Expect = 1e-16
 Identities = 64/197 (32%), Positives = 103/197 (52%), Gaps = 9/197 (4%)

Query: 26  RRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTG 85
           R + L  K  +VT ++ GIG  +A  LA+ GAHVVV++R ++ + + V+     G +   
Sbjct: 28  RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAH 87

Query: 86  TVCHVGKAED---RERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINV 142
            +   G  ED    E+ VA A KL GG+D+L+ N   N       D    V  K++++N 
Sbjct: 88  YI--AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHV-RKSMEVNF 144

Query: 143 KAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIE--L 200
            +  ++T A +P M K+  GS+V+VSS+A     P  + Y+ SK AL G   ++  E  +
Sbjct: 145 LSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV 203

Query: 201 APRNIRVNCLAPGLIKT 217
           +  N+ +     GLI T
Sbjct: 204 SRVNVSITLCVLGLIDT 220


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 83.2 bits (204), Expect = 2e-16
 Identities = 62/206 (30%), Positives = 96/206 (46%), Gaps = 25/206 (12%)

Query: 30  LANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCH 89
           L N V ++T +T G+G   A+     GA +V+  R    +++ +  L         T  H
Sbjct: 50  LRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIREL---------TASH 100

Query: 90  VGKAE------------DRERLVATAVKL---HGGIDILVSNAAVNPFFGSIMDVTEEVW 134
             K +            D   +VA A ++    G +DILV+NA ++ + G+IMD T +V 
Sbjct: 101 ATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGIS-YRGTIMDTTVDVD 159

Query: 135 DKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTK 194
            + ++ N   P  +TKA++P M KR  G +V +SSI      P  S Y  SK A      
Sbjct: 160 KRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFD 219

Query: 195 TLAIELAPRNIRVNCLAPGLIKTSFS 220
            L  E+    I V  ++PG I T+ S
Sbjct: 220 CLRAEMEQYEIEVTVISPGYIHTNLS 245


>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
          Length = 736

 Score = 81.3 bits (199), Expect = 9e-16
 Identities = 74/255 (29%), Positives = 119/255 (46%), Gaps = 26/255 (10%)

Query: 33  KVALVTASTDGIGFAIARRLAQDGAHVVVSS---------RKQQNVDQAVATLQGEGLSV 83
           +V LVT +  G+G A A   A+ GA VVV+          +     D+ V  ++  G   
Sbjct: 10  RVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKA 69

Query: 84  TGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVK 143
              V +    E+ E++V TA+   G ID++V+NA +     S   +++E WD    ++++
Sbjct: 70  ---VANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRD-RSFARISDEDWDIIHRVHLR 125

Query: 144 APALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPR 203
               +T+A    M+K+  G +++ SS +    + G + Y+ +K  LLGL  +LAIE    
Sbjct: 126 GSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKS 185

Query: 204 NIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYI 263
           NI  N +AP     + SRM        E + E L+      PE  A +V +LC E     
Sbjct: 186 NIHCNTIAP----NAGSRM--TQTVMPEDLVEALK------PEYVAPLVLWLCHESCEE- 232

Query: 264 TGETVVVGGGTPSRL 278
            G    VG G   +L
Sbjct: 233 NGGLFEVGAGWIGKL 247


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 57/219 (26%), Positives = 101/219 (46%), Gaps = 8/219 (3%)

Query: 26  RRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTG 85
           RR  +A ++ L+T +  GIG       A+  + +V+    ++ V++  A  +  G++   
Sbjct: 30  RRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHA 89

Query: 86  TVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAP 145
            V      E+  R +    K  G + I+V+NA    +   ++   +E   KT ++N+   
Sbjct: 90  YVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGT-VYPADLLSTKDEEITKTFEVNILGH 148

Query: 146 ALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIE---LAP 202
             +TKA++P M +R  G +V V+S+      P   PY  SK A +G  + L  E   L  
Sbjct: 149 FWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGK 208

Query: 203 RNIRVNCLAPGLIKTSF----SRMLWMDKEKEESMKETL 237
             I+ +CL P  + T F    S  LW   E +E ++  +
Sbjct: 209 TGIKTSCLCPVFVNTGFTKNPSTRLWPVLETDEVVRSLI 247


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score = 79.0 bits (193), Expect = 4e-15
 Identities = 66/215 (30%), Positives = 96/215 (44%), Gaps = 20/215 (9%)

Query: 33  KVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATL--QGEGLSVTGTVCHV 90
           KVALVT +  GIG A A  L   GA V +     +   Q  A L  Q E        C V
Sbjct: 6   KVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDV 65

Query: 91  GKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTK 150
              +         V   G +DILV+NA VN          E+ W+KTL IN+ +    T 
Sbjct: 66  ADQQQLRDTFRKVVDHFGRLDILVNNAGVN---------NEKNWEKTLQINLVSVISGTY 116

Query: 151 AVVPEMEKRGGGS---VVIVSSIAAFSPSPGFSPYNVSKTALLGLTKT--LAIELAPRNI 205
             +  M K+ GG    ++ +SS+A   P      Y  SK  ++G T++  LA  L    +
Sbjct: 117 LGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGV 176

Query: 206 RVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIR 240
           R+N + PG + T+    +    EKEE+M + +  +
Sbjct: 177 RLNAICPGFVNTAILESI----EKEENMGQYIEYK 207


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score = 78.2 bits (191), Expect = 7e-15
 Identities = 59/200 (29%), Positives = 92/200 (46%), Gaps = 10/200 (5%)

Query: 26  RRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTG 85
           RR  +  ++ L+T +  GIG   A   A+  + +V+    +  +++  A  +G G  V  
Sbjct: 30  RRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHT 89

Query: 86  TVCHVGKAEDRERLVATAVKLH---GGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINV 142
            V      ED   + ++A K+    G + ILV+NA V  +   +    +   +KT ++NV
Sbjct: 90  FVVDCSNRED---IYSSAKKVKAEIGDVSILVNNAGV-VYTSDLFATQDPQIEKTFEVNV 145

Query: 143 KAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAP 202
            A    TKA +P M K   G +V V+S A     P    Y  SK A +G  KTL  ELA 
Sbjct: 146 LAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAA 205

Query: 203 ---RNIRVNCLAPGLIKTSF 219
                ++  CL P  + T F
Sbjct: 206 LQITGVKTTCLCPNFVNTGF 225


>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
          Length = 311

 Score = 77.4 bits (189), Expect = 1e-14
 Identities = 55/195 (28%), Positives = 92/195 (47%), Gaps = 4/195 (2%)

Query: 31  ANKVALVTASTDGIGFAIARRLAQDGA--HVVVSSRKQQNVDQAVATLQGEGLSVTGTVC 88
           A +  L++  + GIG  +A +LA D    + VV++ +     + +    GE L  T TV 
Sbjct: 4   APRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVA 63

Query: 89  HVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALM 148
            +    D E +      + G +D+LV+NA +    G +  ++        D N      +
Sbjct: 64  QLDVCSD-ESVAQCLSCIQGEVDVLVNNAGMG-LVGPLEGLSLAAMQNVFDTNFFGAVRL 121

Query: 149 TKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVN 208
            KAV+P M++R  G +V++SS+           Y  SK AL G  ++LAI+L   NI ++
Sbjct: 122 VKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFIS 181

Query: 209 CLAPGLIKTSFSRML 223
            + PG + T F   L
Sbjct: 182 LVEPGPVVTEFEGKL 196


>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
           sapiens]
          Length = 330

 Score = 74.7 bits (182), Expect = 8e-14
 Identities = 56/189 (29%), Positives = 97/189 (51%), Gaps = 5/189 (2%)

Query: 35  ALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAE 94
           A+V+ +TDGIG A A  LA  G ++++ SR ++ + Q VA    +   V   +     + 
Sbjct: 70  AVVSGATDGIGKAYAEELASRGLNIILISRNEEKL-QVVAKDIADTYKVETDIIVADFSS 128

Query: 95  DRERLVATAVKLHG-GIDILVSNAAV-NPFFGSIMDVTEE-VWDKTLDINVKAPALMTKA 151
            RE  +     L    + ILV+N  V  P+      ++E+ +WD  +++N+ A +LM   
Sbjct: 129 GREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWD-IINVNIAAASLMVHV 187

Query: 152 VVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLA 211
           V+P M +R  G++V +SS +   P+P  + ++ SK  L   ++ L  E A + I V  L 
Sbjct: 188 VLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLI 247

Query: 212 PGLIKTSFS 220
           P  + TS +
Sbjct: 248 PFYVATSMT 256


>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
           sapiens]
          Length = 328

 Score = 73.9 bits (180), Expect = 1e-13
 Identities = 56/201 (27%), Positives = 94/201 (46%), Gaps = 19/201 (9%)

Query: 30  LANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGL---SVTGT 86
           +A  V L+T  + GIG  +A RLA D +       +   V   +  L+ +G    +    
Sbjct: 1   MARTVVLITGCSSGIGLHLAVRLASDPS-------QSFKVYATLRDLKTQGRLWEAARAL 53

Query: 87  VCHVGKAE-------DRERLVATAVKL-HGGIDILVSNAAVNPFFGSIMDVTEEVWDKTL 138
            C  G  E       D + + A   ++  G +D+LV NA +    G +  + E+     L
Sbjct: 54  ACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLG-LLGPLEALGEDAVASVL 112

Query: 139 DINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAI 198
           D+NV     M +A +P+M++RG G V++  S+      P    Y  SK AL GL ++LA+
Sbjct: 113 DVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAV 172

Query: 199 ELAPRNIRVNCLAPGLIKTSF 219
            L P  + ++ +  G + T+F
Sbjct: 173 LLLPFGVHLSLIECGPVHTAF 193


>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
          Length = 312

 Score = 72.8 bits (177), Expect = 3e-13
 Identities = 59/217 (27%), Positives = 108/217 (49%), Gaps = 15/217 (6%)

Query: 12  RAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQ 71
           R W     A  G     P   + A+VT STDGIG + A  LA+ G  VV+ SR +  +DQ
Sbjct: 35  RVWGVGNEAGVG-----PGLGEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQ 89

Query: 72  AVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDI--LVSNAAVN----PFFGS 125
             + ++ +    T T+     +ED    + T +    G++I  LV+N  ++     +F  
Sbjct: 90  VSSEIKEKFKVETRTIAVDFASEDIYDKIKTGL---AGLEIGILVNNVGMSYEYPEYFLD 146

Query: 126 IMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVS 185
           + D+ + V  K ++IN+ +   MT+ V+P M +R  G+++ +SS +   P P  + Y+ +
Sbjct: 147 VPDL-DNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSAT 205

Query: 186 KTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRM 222
           KT +   ++ L  E   + + V  + P  + T  +++
Sbjct: 206 KTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLAKI 242


>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
           [Homo sapiens]
          Length = 261

 Score = 71.2 bits (173), Expect = 9e-13
 Identities = 66/250 (26%), Positives = 111/250 (44%), Gaps = 17/250 (6%)

Query: 34  VALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKA 93
           VA++T    G+G A A RL   GA  V+        +     L   G +       V   
Sbjct: 12  VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL---GNNCVFAPADVTSE 68

Query: 94  EDRERLVATAVKLHGGIDILVSNAAVNPFFGSI-----MDVTEEVWDKTLDINVKAPALM 148
           +D +  +A A    G +D+ V+ A +     +         T E + + LD+N+     +
Sbjct: 69  KDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNV 128

Query: 149 TKAVVPEMEK----RGG--GSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAP 202
            + V  EM +    +GG  G ++  +S+AAF    G + Y+ SK  ++G+T  +A +LAP
Sbjct: 129 IRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAP 188

Query: 203 RNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASY 262
             IRV  +APGL  T     L  +K       +     RLG+P + A +V  +   +  +
Sbjct: 189 IGIRVMTIAPGLFGTPLLTSL-PEKVCNFLASQVPFPSRLGDPAEYAHLVQAII--ENPF 245

Query: 263 ITGETVVVGG 272
           + GE + + G
Sbjct: 246 LNGEVIRLDG 255


>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
          Length = 309

 Score = 69.3 bits (168), Expect = 3e-12
 Identities = 51/195 (26%), Positives = 89/195 (45%), Gaps = 5/195 (2%)

Query: 27  RDPLANKVALVTASTDGIGFAIARRLAQDGAHVVV-SSRKQQNVDQAVATLQGEGLSVTG 85
           R  +A ++ L+T +  G+G  +A + A+ G+ +V+    K+ N +      +     V  
Sbjct: 35  RKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHA 94

Query: 86  TVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAP 145
             C   + E   R+     K  G + IL++NA +       +D  +E+ +K+ D+N KA 
Sbjct: 95  YTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTG-KKFLDCPDELMEKSFDVNFKAH 153

Query: 146 ALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIEL---AP 202
               KA +P M     G +V +SS A  S   G + Y  SK A  G  +++ +E      
Sbjct: 154 LWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQ 213

Query: 203 RNIRVNCLAPGLIKT 217
           + I+   + P  IKT
Sbjct: 214 KGIKTTIVCPFFIKT 228


>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
           sapiens]
          Length = 302

 Score = 68.2 bits (165), Expect = 8e-12
 Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 2/172 (1%)

Query: 30  LANKVALVTASTDGIGFAIARRLAQDGAH-VVVSSRKQQNVDQAVATLQGEGLSVTGTVC 88
           L+ +  L+T    GIG  +AR  A+ GA  +V+  R ++ + +    ++  G      +C
Sbjct: 36  LSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFIC 95

Query: 89  HVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALM 148
            VG  E+  +      +  G I ILV+NAAV     S+MD  ++   K+  IN       
Sbjct: 96  DVGNREEVYQTAKAVREKVGDITILVNNAAV-VHGKSLMDSDDDALLKSQHINTLGQFWT 154

Query: 149 TKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIEL 200
           TKA +P M +   G +V ++S+ A S  PG   Y  SK +     ++L + L
Sbjct: 155 TKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGL 206


>gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
          Length = 310

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 56/215 (26%), Positives = 101/215 (46%), Gaps = 9/215 (4%)

Query: 35  ALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGE-GLSVTGTVCHVGKA 93
           A++T + DGIG A +  LA+ G +VV+ SR  + ++     ++   G SV        K 
Sbjct: 51  AVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKD 110

Query: 94  EDRERLVATAVKLHGGIDILVSNAAVNPFF--GSIMDVTEEVWDKTLDINVKAPALMTKA 151
           +  E +      L   I ILV+N  + P       ++  +E+    +  N+ +   MT+ 
Sbjct: 111 DIYEHIKEKLAGLE--IGILVNNVGMLPNLLPSHFLNAPDEI-QSLIHCNITSVVKMTQL 167

Query: 152 VVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLA 211
           ++  ME R  G ++ +SS  A  P P +S Y+ SK  +   +K L  E   + + +  L 
Sbjct: 168 ILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLT 227

Query: 212 PGLIKTSFSRML---WMDKEKEESMKETLRIRRLG 243
           P  + T+ ++ L    + K  +E +KE+L    +G
Sbjct: 228 PYAVSTAMTKYLNTNVITKTADEFVKESLNYVTIG 262


>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 49/191 (25%), Positives = 93/191 (48%), Gaps = 7/191 (3%)

Query: 28  DPLANKVALVTASTDGIGFAIARRLAQDG----AHVVVSSRKQQNVDQAVATLQGEGLSV 83
           +P+ +K  LVT    G GF++A+ L   G    A  ++  +    V +  +       +V
Sbjct: 51  EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110

Query: 84  TGTVCHVGKAEDRERLVATAVK-LHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINV 142
              VC   + E    +V +++K    G+  LV+NA ++ F G +   + E + +  ++N+
Sbjct: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTF-GEVEFTSLETYKQVAEVNL 169

Query: 143 KAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAP 202
                MTK+ +P + +R  G VV +SS+     +P  SPY ++K  +   +  L  E+ P
Sbjct: 170 WGTVRMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYP 228

Query: 203 RNIRVNCLAPG 213
             ++V+ + PG
Sbjct: 229 LGVKVSVVEPG 239


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,926,136
Number of Sequences: 37866
Number of extensions: 409810
Number of successful extensions: 1013
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 859
Number of HSP's gapped (non-prelim): 87
length of query: 278
length of database: 18,247,518
effective HSP length: 101
effective length of query: 177
effective length of database: 14,423,052
effective search space: 2552880204
effective search space used: 2552880204
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.