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Search of human proteins with 29648315
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29648315 small G protein signaling modulator 3 [Homo
sapiens]
(749 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29648315 small G protein signaling modulator 3 [Homo sapiens] 1509 0.0
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 204 2e-52
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 201 2e-51
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 182 1e-45
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 175 2e-43
gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso... 164 2e-40
gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso... 164 2e-40
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso... 164 2e-40
gi|156231067 TBC1 domain family, member 8 [Homo sapiens] 157 3e-38
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 131 2e-30
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 126 8e-29
gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 122 1e-27
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 121 2e-27
gi|68299759 ecotropic viral integration site 5 [Homo sapiens] 120 4e-27
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 120 4e-27
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 119 1e-26
gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 116 9e-26
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 116 9e-26
gi|38570103 TBC1 domain family, member 8B (with GRAM domain) iso... 114 3e-25
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 108 2e-23
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 107 5e-23
gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 103 4e-22
gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 103 4e-22
gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 103 4e-22
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 102 1e-21
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 102 1e-21
gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens] 86 2e-16
gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens] 86 2e-16
gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens] 86 2e-16
gi|148806902 TBC1 domain family, member 12 [Homo sapiens] 76 1e-13
>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
Length = 749
Score = 1509 bits (3908), Expect = 0.0
Identities = 749/749 (100%), Positives = 749/749 (100%)
Query: 1 MSGSHTPACGPFSALTPSIWPQEILAKYTQKEESAEQPEFYYDEFGFRVYKEEGDEPGSS 60
MSGSHTPACGPFSALTPSIWPQEILAKYTQKEESAEQPEFYYDEFGFRVYKEEGDEPGSS
Sbjct: 1 MSGSHTPACGPFSALTPSIWPQEILAKYTQKEESAEQPEFYYDEFGFRVYKEEGDEPGSS 60
Query: 61 LLANSPLMEDAPQRLRWQAHLEFTHNHDVGDLTWDKIAVSLPRSEKLRSLVLAGIPHGMR 120
LLANSPLMEDAPQRLRWQAHLEFTHNHDVGDLTWDKIAVSLPRSEKLRSLVLAGIPHGMR
Sbjct: 61 LLANSPLMEDAPQRLRWQAHLEFTHNHDVGDLTWDKIAVSLPRSEKLRSLVLAGIPHGMR 120
Query: 121 PQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSIG 180
PQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSIG
Sbjct: 121 PQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSIG 180
Query: 181 VPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFWMMSAIIEDLLPASYFSTT 240
VPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFWMMSAIIEDLLPASYFSTT
Sbjct: 181 VPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFWMMSAIIEDLLPASYFSTT 240
Query: 241 LLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDL 300
LLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDL
Sbjct: 241 LLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDL 300
Query: 301 FFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLSDIPSQMEDAELLLGVAMRLAGS 360
FFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLSDIPSQMEDAELLLGVAMRLAGS
Sbjct: 301 FFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLSDIPSQMEDAELLLGVAMRLAGS 360
Query: 361 LTDVAVETQRRKHLAYLIADQGQLLGAGTLTNLSQVVRRRTQRRKSTITALLFGEDDLEA 420
LTDVAVETQRRKHLAYLIADQGQLLGAGTLTNLSQVVRRRTQRRKSTITALLFGEDDLEA
Sbjct: 361 LTDVAVETQRRKHLAYLIADQGQLLGAGTLTNLSQVVRRRTQRRKSTITALLFGEDDLEA 420
Query: 421 LKAKNIKQTELVADLREAILRVARHFQCTDPKNCSVELTPDYSMESHQRDHENYVACSRS 480
LKAKNIKQTELVADLREAILRVARHFQCTDPKNCSVELTPDYSMESHQRDHENYVACSRS
Sbjct: 421 LKAKNIKQTELVADLREAILRVARHFQCTDPKNCSVELTPDYSMESHQRDHENYVACSRS 480
Query: 481 HRRRAKALLDFERHDDDELGFRKNDIITIVSQKDEHCWVGELNGLRGWFPAKFVEVLDER 540
HRRRAKALLDFERHDDDELGFRKNDIITIVSQKDEHCWVGELNGLRGWFPAKFVEVLDER
Sbjct: 481 HRRRAKALLDFERHDDDELGFRKNDIITIVSQKDEHCWVGELNGLRGWFPAKFVEVLDER 540
Query: 541 SKEYSIAGDDSVTEGVTDLVRGTLCPALKALFEHGLKKPSLLGGACHPWLFIEEAAGREV 600
SKEYSIAGDDSVTEGVTDLVRGTLCPALKALFEHGLKKPSLLGGACHPWLFIEEAAGREV
Sbjct: 541 SKEYSIAGDDSVTEGVTDLVRGTLCPALKALFEHGLKKPSLLGGACHPWLFIEEAAGREV 600
Query: 601 ERDFASVYSRLVLCKTFRLDEDGKVLTPEELLYRAVQSVNVTHDAVHAQMDVKLRSLICV 660
ERDFASVYSRLVLCKTFRLDEDGKVLTPEELLYRAVQSVNVTHDAVHAQMDVKLRSLICV
Sbjct: 601 ERDFASVYSRLVLCKTFRLDEDGKVLTPEELLYRAVQSVNVTHDAVHAQMDVKLRSLICV 660
Query: 661 GLNEQVLHLWLEVLCSSLPTVEKWYQPWSFLRSPGWVQIKCELRVLCCFAFSLSQDWELP 720
GLNEQVLHLWLEVLCSSLPTVEKWYQPWSFLRSPGWVQIKCELRVLCCFAFSLSQDWELP
Sbjct: 661 GLNEQVLHLWLEVLCSSLPTVEKWYQPWSFLRSPGWVQIKCELRVLCCFAFSLSQDWELP 720
Query: 721 AKREAQQPLKEGVRDMLVKHHLFSWDVDG 749
AKREAQQPLKEGVRDMLVKHHLFSWDVDG
Sbjct: 721 AKREAQQPLKEGVRDMLVKHHLFSWDVDG 749
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 204 bits (520), Expect = 2e-52
Identities = 128/387 (33%), Positives = 197/387 (50%), Gaps = 30/387 (7%)
Query: 6 TPACGPFSALTPSIWPQEILAKYTQKEESAEQPE---------FYYDEFGFRVYKEEGDE 56
TP C T + Q L + + ES EQPE YD +GFR E+ +E
Sbjct: 551 TPVCSEDQGPTREVIAQ--LLEDALQVESQEQPEQAFVKPHLVSEYDIYGFRTVPEDDEE 608
Query: 57 PGSSLLANSPLMEDAPQRLRWQAHLEFTHNHDVGD-LTWDKIAVSLPRSE-----KLRSL 110
L+A ++ L T N +V + W+ S E +L++L
Sbjct: 609 --EKLVAKVRALD--------LKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNL 658
Query: 111 VLAGIPHGMRPQLWMRLSGALQKKRNSELS---YREIVKNSSNDETIAAKQIEKDLLRTM 167
+ AGIPH R ++W +K ++ +++ + + A+KQIE DLLRT+
Sbjct: 659 IRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDLLRTL 718
Query: 168 PSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFWMMSAI 227
P+N ++ S G+ +LR VL A +W P+IGYCQG + A LL+LE+EDAFW + I
Sbjct: 719 PNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTI 778
Query: 228 IEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFLTAFAS 287
+E +P Y++ TLLG Q DQRV R L+ + LPRL +++ ++ +LIT +WFL F
Sbjct: 779 VEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVD 838
Query: 288 VVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLSDIPSQMEDA 347
V +L +IWD F YEG +V+F+ L + KEEE+++ ++S SIF L + DA
Sbjct: 839 SVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFTRTILDA 898
Query: 348 ELLLGVAMRLAGSLTDVAVETQRRKHL 374
L+ ++ + +R HL
Sbjct: 899 RKLISISFGDLNPFPLRQIRNRRAYHL 925
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 201 bits (511), Expect = 2e-51
Identities = 124/360 (34%), Positives = 188/360 (52%), Gaps = 30/360 (8%)
Query: 6 TPACGPFSALTPSIWPQEILAKYTQKEESAEQPE---------FYYDEFGFRVYKEEGDE 56
TP C T + Q L + + ES EQPE YD +GFR E+ +E
Sbjct: 551 TPVCSEDQGPTREVIAQ--LLEDALQVESQEQPEQAFVKPHLVSEYDIYGFRTVPEDDEE 608
Query: 57 PGSSLLANSPLMEDAPQRLRWQAHLEFTHNHDVGD-LTWDKIAVSLPRSE-----KLRSL 110
L+A ++ L T N +V + W+ S E +L++L
Sbjct: 609 --EKLVAKVRALD--------LKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNL 658
Query: 111 VLAGIPHGMRPQLWMRLSGALQKKRNSELS---YREIVKNSSNDETIAAKQIEKDLLRTM 167
+ AGIPH R ++W +K ++ +++ + + A+KQIE DLLRT+
Sbjct: 659 IRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDLLRTL 718
Query: 168 PSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFWMMSAI 227
P+N ++ S G+ +LR VL A +W P+IGYCQG + A LL+LE+EDAFW + I
Sbjct: 719 PNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTI 778
Query: 228 IEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFLTAFAS 287
+E +P Y++ TLLG Q DQRV R L+ + LPRL +++ ++ +LIT +WFL F
Sbjct: 779 VEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVD 838
Query: 288 VVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLSDIPSQMEDA 347
V +L +IWD F YEG +V+F+ L + KEEE+++ ++S SIF L + DA
Sbjct: 839 SVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFTRTILDA 898
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 182 bits (461), Expect = 1e-45
Identities = 131/394 (33%), Positives = 189/394 (47%), Gaps = 55/394 (13%)
Query: 42 YDEFGFRVYKEEGDEPGSSLLANSPLME------------DAPQRLRWQAHLEFTHNHDV 89
YDE+GF + E LLA +E D P R RW A +
Sbjct: 560 YDEYGFLTVPDYEVED-LKLLAKIQALESRSHHLLGLEAVDRPLRERWAA---------L 609
Query: 90 GDLTWDKIAVSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSS 149
GDL S +L+ L+ AG+P RP++W L + ++ Y+E++
Sbjct: 610 GDLV---------PSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQ 660
Query: 150 NDETIAAKQIEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAA 209
E AA+QIE DL RT P+N F S +LRRVL A +W P IGYCQG +AA
Sbjct: 661 AREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAA 720
Query: 210 CLLLFLEEED-AFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQE 268
LL LEEE+ AFW + AI+E ++PA Y+ TL Q DQRVL+ L+ + LPRL L +
Sbjct: 721 IALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQ 780
Query: 269 HDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSE 328
H ++LSL+T +WFL FA + +LLR+WD F YEG++ E+E+++ +
Sbjct: 781 HHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGTK-----------YNEKEILRLQ 829
Query: 329 NSASIFNTLSDIPSQMEDAELLLGVAMRLAGSLTDVAVETQRRKHLAYLIADQGQLLGAG 388
N I+ L + ++ L+ +A + R H L A+
Sbjct: 830 NGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAE-------- 881
Query: 389 TLTNLSQVVRRRTQRRKSTITALLFG---EDDLE 419
L L Q+ +RR S A+ G ED++E
Sbjct: 882 -LRELEQLKAEYLERRASRRRAVSEGCASEDEVE 914
>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
sapiens]
Length = 1266
Score = 175 bits (443), Expect = 2e-43
Identities = 96/265 (36%), Positives = 152/265 (57%), Gaps = 4/265 (1%)
Query: 99 VSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQ 158
+ + R+EK R LVL GIP MR +LW+ LSGA+ +K Y ++V+ S +A ++
Sbjct: 500 ICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEE 559
Query: 159 IEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEE 218
IE+DL R++P + F +G+ LRRVL A A+ P IGYCQ +V + LLL+ +EE
Sbjct: 560 IERDLHRSLPEHPAF--QNEMGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEE 617
Query: 219 DAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITL 278
+AFW++ A+ E +LP Y++T ++G DQ V L Y+P+L +Q+ + +S I+L
Sbjct: 618 EAFWLLVALCERMLP-DYYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGV-ISTISL 675
Query: 279 HWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLS 338
WFLT F SV+ + + + D FFYEG +V+FQL L +L ++L+ ++ L
Sbjct: 676 SWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDGEAMTVLG 735
Query: 339 DIPSQMEDAELLLGVAMRLAGSLTD 363
+ + + L L L+D
Sbjct: 736 RYLDSVTNKDSTLPPIPHLHSLLSD 760
>gi|45597177 TBC1 domain family, member 9B (with GRAM domain)
isoform b [Homo sapiens]
Length = 1233
Score = 164 bits (416), Expect = 2e-40
Identities = 89/227 (39%), Positives = 140/227 (61%), Gaps = 4/227 (1%)
Query: 99 VSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQ 158
V + R+ K R+LVL GIP +R +LW+ SGA + Y E+V+ S+ ++A ++
Sbjct: 493 VCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEE 552
Query: 159 IEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEE 218
IE+DL R+MP + F + +G+ LRRVL A A+ P IGYCQ +V + LLL+ EE
Sbjct: 553 IERDLHRSMPEHPAFQN--ELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEE 610
Query: 219 DAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITL 278
+AFW++ A+ E +LP Y++T ++G DQ + L +LP+L + +Q+ + +S I+L
Sbjct: 611 EAFWLLVALCERMLP-DYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGV-ISSISL 668
Query: 279 HWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELI 325
WFLT F SV+ + + I D FFYEG +V+ Q+ L +L E+L+
Sbjct: 669 SWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLL 715
>gi|45597175 TBC1 domain family, member 9B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1250
Score = 164 bits (416), Expect = 2e-40
Identities = 89/227 (39%), Positives = 140/227 (61%), Gaps = 4/227 (1%)
Query: 99 VSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQ 158
V + R+ K R+LVL GIP +R +LW+ SGA + Y E+V+ S+ ++A ++
Sbjct: 493 VCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEE 552
Query: 159 IEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEE 218
IE+DL R+MP + F + +G+ LRRVL A A+ P IGYCQ +V + LLL+ EE
Sbjct: 553 IERDLHRSMPEHPAFQN--ELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEE 610
Query: 219 DAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITL 278
+AFW++ A+ E +LP Y++T ++G DQ + L +LP+L + +Q+ + +S I+L
Sbjct: 611 EAFWLLVALCERMLP-DYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGV-ISSISL 668
Query: 279 HWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELI 325
WFLT F SV+ + + I D FFYEG +V+ Q+ L +L E+L+
Sbjct: 669 SWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLL 715
>gi|38570101 TBC1 domain family, member 8B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1120
Score = 164 bits (416), Expect = 2e-40
Identities = 89/240 (37%), Positives = 143/240 (59%), Gaps = 4/240 (1%)
Query: 99 VSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQ 158
VS+ R++K R LV+ GIP +R +LWM SGA+ + Y E+V+ S +A ++
Sbjct: 472 VSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEE 531
Query: 159 IEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEE 218
IE+DL R++P + F S G+ LRRVL A A+ P+IGYCQ ++ + LLL+ +EE
Sbjct: 532 IERDLRRSLPEHPAFQS--DTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEE 589
Query: 219 DAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITL 278
+AFW++ A+ E +LP YF+ ++G DQ V LI +LP+L + + + S ++L
Sbjct: 590 EAFWLLVAVCERMLP-DYFNRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTF-FSSVSL 647
Query: 279 HWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLS 338
WFLT F SV+ I+ + + D FFY+G + + QL L +L ++L+ ++ A L+
Sbjct: 648 SWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLTCKDDAEAVTALN 707
>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
Length = 1140
Score = 157 bits (397), Expect = 3e-38
Identities = 86/240 (35%), Positives = 139/240 (57%), Gaps = 4/240 (1%)
Query: 99 VSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQ 158
V + R+EK+R LV GIP +R +LW+ S A+ + Y +V+ S + ++
Sbjct: 490 VCMFRTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEESLGKCCLVTEE 549
Query: 159 IEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEE 218
IE+DL R++P + F + G+ LRRVL A A P+IGYCQ ++ + LLL+ +EE
Sbjct: 550 IERDLHRSLPEHPAFQN--ETGIAALRRVLTAYAHRNPKIGYCQSMNILTSVLLLYTKEE 607
Query: 219 DAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITL 278
+AFW++ A+ E +LP YF+ ++G Q DQ V LI +LP L + + + L+ ++L
Sbjct: 608 EAFWLLVAVCERMLP-DYFNHRVIGAQVDQSVFEELIKGHLPELAEHMNDLS-ALASVSL 665
Query: 279 HWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLS 338
WFLT F S++ ++ + + D FFY+G + +FQL L +L E+L S++ LS
Sbjct: 666 SWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAEDLCSSKDDGQALMILS 725
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 131 bits (330), Expect = 2e-30
Identities = 84/283 (29%), Positives = 143/283 (50%), Gaps = 7/283 (2%)
Query: 101 LPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIE 160
+PRS ++ V G+P R ++WM LSGA + + Y ++++ N A I
Sbjct: 55 VPRSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDA--IR 112
Query: 161 KDLLRTMPSNACFASMGSIGVPR-LRRVLRALAWLYPEIGYCQGTGMVAACLLLFLE-EE 218
DL RT P N F + R L VL A +GYCQG +A L+L EE
Sbjct: 113 TDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEE 172
Query: 219 DAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITL 278
++FW++ A++ +LP Y+S +LG++TDQ VL L+ LP + L++ + +L+
Sbjct: 173 ESFWLLDALVGRILP-DYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVS 231
Query: 279 HWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLS 338
WF+ F ++ ++ +LRIWD F EGS+++F++ L ++ +E ++++ + I +
Sbjct: 232 RWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFK 291
Query: 339 DIP--SQMEDAELLLGVAMRLAGSLTDVAVETQRRKHLAYLIA 379
I S + + + GSL+ V R A L+A
Sbjct: 292 QITKGSFVMECHTFMQKIFSEPGSLSMATVAKLRESCRARLLA 334
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 126 bits (316), Expect = 8e-29
Identities = 87/275 (31%), Positives = 131/275 (47%), Gaps = 19/275 (6%)
Query: 43 DEFGFRVYKEEGDEPGSSLLANSPLMEDAPQRLRWQAHLEFTHNHDVGDLTWDKIAVSLP 102
D+FGF V G + L PL + +W L+ +N WDK
Sbjct: 56 DKFGFIV----GSQGAEGALEEVPLEVLRQRESKW---LDMLNN-------WDKWMAK-- 99
Query: 103 RSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIEKD 162
+ +K+R GIP +R + W LSG K + + + E+ + + + + IE+D
Sbjct: 100 KHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDV--IERD 157
Query: 163 LLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFW 222
L R P + F S G G L RVL+A PE GYCQ +AA LL+ + E AFW
Sbjct: 158 LHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFW 217
Query: 223 MMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFL 282
+ I E LP Y+S L +Q D +L L+ + P K L I+ L WF+
Sbjct: 218 CLVQICEKYLP-GYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFM 276
Query: 283 TAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGML 317
AF+ + +LR+WD+FF EG +++F++ L +L
Sbjct: 277 CAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLL 311
>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
Length = 446
Score = 122 bits (306), Expect = 1e-27
Identities = 81/248 (32%), Positives = 125/248 (50%), Gaps = 7/248 (2%)
Query: 103 RSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIEKD 162
R +K++ GIP +R + W L GA ++NS +Y+E+ + + + + + I +D
Sbjct: 81 RYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWM--ETIGRD 138
Query: 163 LLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFW 222
L R P + F S G L +VL+A PE GYCQ G VAA LL+ L E+AFW
Sbjct: 139 LHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFW 198
Query: 223 MMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFL 282
+ I E LP Y+ + V+ D V L+ + LP + K LQ+ + L WFL
Sbjct: 199 CLVQICEVYLP-GYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFL 257
Query: 283 TAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLSDI-- 340
FA + +LR+WD F EG+RVLF++ L ++ L Q + TL +
Sbjct: 258 CLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRA 317
Query: 341 --PSQMED 346
P+Q+++
Sbjct: 318 IPPAQLQE 325
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 121 bits (304), Expect = 2e-27
Identities = 93/345 (26%), Positives = 156/345 (45%), Gaps = 24/345 (6%)
Query: 43 DEFGFRVYKEEGDEPGSSLLANSPLMEDAPQRLRWQAHLEFTHNHDVGDLTWDKIAVSLP 102
D++GF G + SL ++ P+ + L+W L+ N WDK
Sbjct: 305 DKYGFL----GGSQYSGSLESSIPVDVARQRELKW---LDMFSN-------WDKWLSR-- 348
Query: 103 RSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIEKD 162
R +K++ GIP +R + W LS + + + + E+ + + + + IEKD
Sbjct: 349 RFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDV--IEKD 406
Query: 163 LLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFW 222
L R P + FA+ G G L R+L+A P+ GYCQ VAA LL+ + E AFW
Sbjct: 407 LHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFW 466
Query: 223 MMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFL 282
+ I + LP Y+S L +Q D + L+ + P + L+ I+ L WF+
Sbjct: 467 CLVQICDKYLP-GYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFM 525
Query: 283 TAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHL---KEEELIQSENSASIFNTLSD 339
FA + +LR+WD+FF EG +++F++ L +L E+L + L +
Sbjct: 526 CIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRN 585
Query: 340 IPSQMEDAELLLGVAMRLAGSLTDVAVETQRRKHLAYLIADQGQL 384
+P Q + L+ L +T+ +E + L +G+L
Sbjct: 586 LPQQCMQEDFLVHEVTNL--PVTEALIERENAAQLKKWRETRGEL 628
>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
Length = 810
Score = 120 bits (302), Expect = 4e-27
Identities = 96/374 (25%), Positives = 163/374 (43%), Gaps = 34/374 (9%)
Query: 6 TPACGPFSALTPSIWPQEILAKYTQKEESAEQPEFYYDEFGFRVYKEEGDEPGSSLLANS 65
TPA P S S E+LAK ++ E D R GSSL+++S
Sbjct: 67 TPALSPSSPSQLSPDDLELLAKLEEQNRLLET-----DSKSLRSVNGSRRNSGSSLVSSS 121
Query: 66 PLMEDAPQRLRWQAHLEFTHNHDVGDLTWDKIA-----VSLPRSEKLRSLVLAGIPHGMR 120
A +H + + W +I V + ++++ LV GIPH R
Sbjct: 122 ------------SASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFR 169
Query: 121 PQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSIG 180
+W L A + Y E++K +S E K I +D+ RT P + F S+G
Sbjct: 170 AIVWQLLCSAQSMPIKDQ--YSELLKMTSPCE----KLIRRDIARTYPEHNFFKEKDSLG 223
Query: 181 VPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFWMMSAIIEDLLPASYFSTT 240
L V++A + + E+GYCQG+ + LL+ + EE+AF + +++D F +
Sbjct: 224 QEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPS 283
Query: 241 LLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDL 300
+ + +I ++LP L Q S+ WFLT F + + + RI+D+
Sbjct: 284 MAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDI 343
Query: 301 FFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLSDIPSQMEDAELLLGVAMRLAGS 360
F EG ++F++ L +L + + EL+Q + + + IP Q + GV +L +
Sbjct: 344 FMSEGLEIVFRVGLALLQMNQAELMQLDMEGMLQHFQKVIPHQFD------GVPDKLIQA 397
Query: 361 LTDVAVETQRRKHL 374
V +++ K L
Sbjct: 398 AYQVKYNSKKMKKL 411
>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
[Homo sapiens]
Length = 1168
Score = 120 bits (302), Expect = 4e-27
Identities = 107/397 (26%), Positives = 186/397 (46%), Gaps = 44/397 (11%)
Query: 94 WDKIAVSLPRS------EKLRSLVLAGIPHGMRPQLWMRLSGALQ-------KKRNSELS 140
W+K+ + RS EK+ S V G+P R ++W L+ K++ ++
Sbjct: 774 WEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVP 833
Query: 141 YREIVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGY 200
Y+E++K ++ + I DL RT P++ F++ G L +L+A + L E+GY
Sbjct: 834 YKELLKQLTSQQ----HAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGY 889
Query: 201 CQGTGMVAACLLLFLEEEDAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLP 260
CQG VA LLL + EE+AF M+ ++ D+ + ++ +Q L L+ Y
Sbjct: 890 CQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHR 949
Query: 261 RLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLK 320
L L+EH+I SL WFLT FAS + + R++D+ F +G+ V+F++ L +L
Sbjct: 950 DLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSH 1009
Query: 321 EEELIQSENSASIFNTL-SDIPS----QME---DAELLLGVAMRLAGSLTDVAVETQRRK 372
+ ++Q EN +I + + S +P+ QME + + +A +L +V + +
Sbjct: 1010 KPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQL--QAYEVEYHVLQEE 1067
Query: 373 HLAYLIADQGQLLGAGTLTNLS------------QVVRRRTQRRKSTITALLFGEDDL-E 419
+ Q + TN S QV R Q ++TI LL E L +
Sbjct: 1068 LIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQ 1127
Query: 420 ALKAKNIKQTELVADLREAILRVA----RHFQCTDPK 452
A+ ++++ L+ + E R A R +CT P+
Sbjct: 1128 AMLTLELERSALLQTVEELRRRSAEPSDREPECTQPE 1164
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 119 bits (297), Expect = 1e-26
Identities = 81/272 (29%), Positives = 136/272 (50%), Gaps = 20/272 (7%)
Query: 92 LTWDKIAVSLPRS-----EKLRSLVLAGIPHGMRPQLWMRLSGALQ---------KKRNS 137
+TWDK ++ E + +L+ G+P R ++W L ALQ K++
Sbjct: 891 ITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFL--ALQYRLRHRLPNKQQPP 948
Query: 138 ELSYREIVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPE 197
++SY+E++K T I DL RT P++ F+ G L +L+A + L E
Sbjct: 949 DISYKELLKQL----TAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKE 1004
Query: 198 IGYCQGTGMVAACLLLFLEEEDAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQ 257
+GYCQG VA LLL + EE AF M+ ++ DL + ++ +Q L L+
Sbjct: 1005 VGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHD 1064
Query: 258 YLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGML 317
Y L L+E++I SL WFLT FAS + + R++D+ F +G+ V+F++ L +L
Sbjct: 1065 YHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLL 1124
Query: 318 HLKEEELIQSENSASIFNTLSDIPSQMEDAEL 349
+E +++ E+ +I L + M +E+
Sbjct: 1125 SSQETLIMECESFENIVEFLKNTLPDMNTSEM 1156
>gi|229577000 ecotropic viral integration site 5-like isoform 1
[Homo sapiens]
Length = 805
Score = 116 bits (290), Expect = 9e-26
Identities = 87/327 (26%), Positives = 150/327 (45%), Gaps = 31/327 (9%)
Query: 7 PACGPFSALTPSIWPQEI--LAKYTQKEESAEQPEFYYDEFGFRVYKEEGDEPGSSLLAN 64
P C P S + ++ P E+ LAK ++ E D R GSSL+++
Sbjct: 19 PTCSPTSD-SENLSPDELELLAKLEEQNRLLEA-----DSKSMRSMNGSRRNSGSSLVSS 72
Query: 65 SPLMEDAPQRLRWQAHLEFTHNHDVGDLTWDKIAVSLP----RSEKL-RSLVLAGIPHGM 119
S A +H + + W +IA R EKL + L+ GIPH
Sbjct: 73 S------------SASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHF 120
Query: 120 RPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSI 179
R +W L A ++ Y E++K SS E K I +D+ RT P + F S+
Sbjct: 121 RAIVWQLLCSATDMPVKNQ--YSELLKMSSPCE----KLIRRDIARTYPEHEFFKGQDSL 174
Query: 180 GVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFWMMSAIIEDLLPASYFST 239
G L V++A + + E+GYCQG+ + LL+ + EE+AF + ++++ F
Sbjct: 175 GQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKP 234
Query: 240 TLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWD 299
++ + +++ + LP L+ + S+ WFLT F + + + R++D
Sbjct: 235 SMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFD 294
Query: 300 LFFYEGSRVLFQLTLGMLHLKEEELIQ 326
+F YEG ++F++ L +L + + EL+Q
Sbjct: 295 IFMYEGLEIVFRVGLALLQVNQAELMQ 321
>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
sapiens]
Length = 794
Score = 116 bits (290), Expect = 9e-26
Identities = 87/327 (26%), Positives = 150/327 (45%), Gaps = 31/327 (9%)
Query: 7 PACGPFSALTPSIWPQEI--LAKYTQKEESAEQPEFYYDEFGFRVYKEEGDEPGSSLLAN 64
P C P S + ++ P E+ LAK ++ E D R GSSL+++
Sbjct: 19 PTCSPTSD-SENLSPDELELLAKLEEQNRLLEA-----DSKSMRSMNGSRRNSGSSLVSS 72
Query: 65 SPLMEDAPQRLRWQAHLEFTHNHDVGDLTWDKIAVSLP----RSEKL-RSLVLAGIPHGM 119
S A +H + + W +IA R EKL + L+ GIPH
Sbjct: 73 S------------SASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHF 120
Query: 120 RPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSI 179
R +W L A ++ Y E++K SS E K I +D+ RT P + F S+
Sbjct: 121 RAIVWQLLCSATDMPVKNQ--YSELLKMSSPCE----KLIRRDIARTYPEHEFFKGQDSL 174
Query: 180 GVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFWMMSAIIEDLLPASYFST 239
G L V++A + + E+GYCQG+ + LL+ + EE+AF + ++++ F
Sbjct: 175 GQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKP 234
Query: 240 TLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWD 299
++ + +++ + LP L+ + S+ WFLT F + + + R++D
Sbjct: 235 SMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFD 294
Query: 300 LFFYEGSRVLFQLTLGMLHLKEEELIQ 326
+F YEG ++F++ L +L + + EL+Q
Sbjct: 295 IFMYEGLEIVFRVGLALLQVNQAELMQ 321
>gi|38570103 TBC1 domain family, member 8B (with GRAM domain)
isoform b [Homo sapiens]
Length = 632
Score = 114 bits (285), Expect = 3e-25
Identities = 59/145 (40%), Positives = 92/145 (63%), Gaps = 3/145 (2%)
Query: 99 VSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQ 158
VS+ R++K R LV+ GIP +R +LWM SGA+ + Y E+V+ S +A ++
Sbjct: 472 VSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEE 531
Query: 159 IEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEE 218
IE+DL R++P + F S G+ LRRVL A A+ P+IGYCQ ++ + LLL+ +EE
Sbjct: 532 IERDLRRSLPEHPAFQS--DTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEE 589
Query: 219 DAFWMMSAIIEDLLPASYFSTTLLG 243
+AFW++ A+ E +LP YF+ ++G
Sbjct: 590 EAFWLLVAVCERMLP-DYFNRRIIG 613
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 108 bits (269), Expect = 2e-23
Identities = 71/270 (26%), Positives = 128/270 (47%), Gaps = 9/270 (3%)
Query: 103 RSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIEKD 162
R + L +LV +G+P +R ++W L+G + + YR ++ S E++ I +D
Sbjct: 527 RPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLD-RYRILITKDSAQESV----ITRD 581
Query: 163 LLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFW 222
+ RT P++ F G G L ++ +A + +IGYCQG +AA LLL + EE AF
Sbjct: 582 IHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFC 641
Query: 223 MMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFL 282
++ I+ D + + L L+ + LP L + ++E + WFL
Sbjct: 642 VLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFL 701
Query: 283 TAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLSDIPS 342
T F + + ++ I DL EG ++F + L +L +E+L+Q++ ++ +P
Sbjct: 702 TLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPK 761
Query: 343 QMEDAELLLGVAMRLAGSLTDVAVETQRRK 372
+ E A RL ++ V T++ K
Sbjct: 762 RYRAEE----NARRLMEQACNIKVPTKKLK 787
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 107 bits (266), Expect = 5e-23
Identities = 72/258 (27%), Positives = 121/258 (46%), Gaps = 8/258 (3%)
Query: 103 RSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIEKD 162
R ++L SLV G+P +R ++W L+G E I K S D I +D
Sbjct: 555 RPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKESPQDSAIT-----RD 609
Query: 163 LLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFW 222
+ RT P++ F G G L ++ +A + EIGYCQG +AA LLL + EE AF
Sbjct: 610 INRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFS 669
Query: 223 MMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFL 282
++ I+ D F + L L+ +Y+P L + +E + WFL
Sbjct: 670 VLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFL 729
Query: 283 TAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLSDIPS 342
T F + + ++ I DL EG V+F + LG+L +++L+ ++ ++ +P
Sbjct: 730 TLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPK 789
Query: 343 QM---EDAELLLGVAMRL 357
+ E+A+ L+ +A +
Sbjct: 790 RYRSEENAKKLMELACNM 807
>gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 103 bits (258), Expect = 4e-22
Identities = 78/258 (30%), Positives = 128/258 (49%), Gaps = 25/258 (9%)
Query: 114 GIPHGMRPQLWMRLSG------ALQKKRNSELSYREIVKNSSNDETIAAKQIEKDLLRTM 167
GIP R ++W+ L+ A+ + ++ E S+ D+ QI KDL RT
Sbjct: 86 GIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNE---RSNPDDDSMGIQIVKDLHRTG 142
Query: 168 PSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLE--EEDAFWMMS 225
S+ C V L+RVL A A +GYCQG ++AA +L +E E DA +M
Sbjct: 143 CSSYCGQEAEQDRVV-LKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMI 201
Query: 226 AIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRL----DKLLQEHDIE--------- 272
+I+ +LP SYF L + D V R L+ LP L D L + + E
Sbjct: 202 YLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPL 261
Query: 273 LSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSAS 332
++ T+ WFLT FA+ + + +L+IWD F+EGS ++ +++L + E++ E +
Sbjct: 262 TNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADE 321
Query: 333 IFNTLSDIPSQMEDAELL 350
++T+ + +M + +LL
Sbjct: 322 FYSTMGRLTQEMLENDLL 339
>gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 103 bits (258), Expect = 4e-22
Identities = 78/258 (30%), Positives = 128/258 (49%), Gaps = 25/258 (9%)
Query: 114 GIPHGMRPQLWMRLSG------ALQKKRNSELSYREIVKNSSNDETIAAKQIEKDLLRTM 167
GIP R ++W+ L+ A+ + ++ E S+ D+ QI KDL RT
Sbjct: 86 GIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNE---RSNPDDDSMGIQIVKDLHRTG 142
Query: 168 PSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLE--EEDAFWMMS 225
S+ C V L+RVL A A +GYCQG ++AA +L +E E DA +M
Sbjct: 143 CSSYCGQEAEQDRVV-LKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMI 201
Query: 226 AIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRL----DKLLQEHDIE--------- 272
+I+ +LP SYF L + D V R L+ LP L D L + + E
Sbjct: 202 YLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPL 261
Query: 273 LSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSAS 332
++ T+ WFLT FA+ + + +L+IWD F+EGS ++ +++L + E++ E +
Sbjct: 262 TNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADE 321
Query: 333 IFNTLSDIPSQMEDAELL 350
++T+ + +M + +LL
Sbjct: 322 FYSTMGRLTQEMLENDLL 339
>gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 103 bits (258), Expect = 4e-22
Identities = 78/258 (30%), Positives = 128/258 (49%), Gaps = 25/258 (9%)
Query: 114 GIPHGMRPQLWMRLSG------ALQKKRNSELSYREIVKNSSNDETIAAKQIEKDLLRTM 167
GIP R ++W+ L+ A+ + ++ E S+ D+ QI KDL RT
Sbjct: 86 GIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNE---RSNPDDDSMGIQIVKDLHRTG 142
Query: 168 PSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLE--EEDAFWMMS 225
S+ C V L+RVL A A +GYCQG ++AA +L +E E DA +M
Sbjct: 143 CSSYCGQEAEQDRVV-LKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMI 201
Query: 226 AIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRL----DKLLQEHDIE--------- 272
+I+ +LP SYF L + D V R L+ LP L D L + + E
Sbjct: 202 YLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPL 261
Query: 273 LSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSAS 332
++ T+ WFLT FA+ + + +L+IWD F+EGS ++ +++L + E++ E +
Sbjct: 262 TNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADE 321
Query: 333 IFNTLSDIPSQMEDAELL 350
++T+ + +M + +LL
Sbjct: 322 FYSTMGRLTQEMLENDLL 339
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 102 bits (254), Expect = 1e-21
Identities = 85/309 (27%), Positives = 140/309 (45%), Gaps = 17/309 (5%)
Query: 23 EILAKYTQKEESAE-QPEFYYDEFGFRVYKEEGDEPGSSLLANSPLMEDAPQRLRWQAHL 81
EI+AKY + E AE +P +++ + VYK D G P A +R Q HL
Sbjct: 17 EIVAKYDRGREGAEIEP---WEDADYLVYKVT-DRFGFLHEEELPDHNVAVER---QKHL 69
Query: 82 EFTHNHDVGDLT--WDKIAVSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSEL 139
E + W+K +EK + GIP +R ++W L + K +
Sbjct: 70 EIERTTKWLKMLKGWEKYK----NTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRD 125
Query: 140 SYREIVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIG 199
Y ++ K+ + + +QI+ D+ RT + F + L VL A + E+G
Sbjct: 126 LYSKL-KHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVG 184
Query: 200 YCQGTGMVAACLLLFLEEEDAFWMMSAIIEDLLPA--SYFSTTLLGVQTDQRVLRHLIVQ 257
YCQG + A LL+++ EEDAFW + + A +F + Q ++ +
Sbjct: 185 YCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNK 244
Query: 258 YLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGML 317
+L +L + L +I S T+ WF F L LRIWD++ +EG RVL ++ +L
Sbjct: 245 FLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTIL 304
Query: 318 HLKEEELIQ 326
L ++ L++
Sbjct: 305 KLHKKHLMK 313
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 102 bits (254), Expect = 1e-21
Identities = 85/309 (27%), Positives = 140/309 (45%), Gaps = 17/309 (5%)
Query: 23 EILAKYTQKEESAE-QPEFYYDEFGFRVYKEEGDEPGSSLLANSPLMEDAPQRLRWQAHL 81
EI+AKY + E AE +P +++ + VYK D G P A +R Q HL
Sbjct: 34 EIVAKYDRGREGAEIEP---WEDADYLVYKVT-DRFGFLHEEELPDHNVAVER---QKHL 86
Query: 82 EFTHNHDVGDLT--WDKIAVSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSEL 139
E + W+K +EK + GIP +R ++W L + K +
Sbjct: 87 EIERTTKWLKMLKGWEKYK----NTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRD 142
Query: 140 SYREIVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIG 199
Y ++ K+ + + +QI+ D+ RT + F + L VL A + E+G
Sbjct: 143 LYSKL-KHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVG 201
Query: 200 YCQGTGMVAACLLLFLEEEDAFWMMSAIIEDLLPA--SYFSTTLLGVQTDQRVLRHLIVQ 257
YCQG + A LL+++ EEDAFW + + A +F + Q ++ +
Sbjct: 202 YCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNK 261
Query: 258 YLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGML 317
+L +L + L +I S T+ WF F L LRIWD++ +EG RVL ++ +L
Sbjct: 262 FLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTIL 321
Query: 318 HLKEEELIQ 326
L ++ L++
Sbjct: 322 KLHKKHLMK 330
>gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]
Length = 413
Score = 85.5 bits (210), Expect = 2e-16
Identities = 69/271 (25%), Positives = 116/271 (42%), Gaps = 22/271 (8%)
Query: 104 SEKLRSLVLAGIPHGMRPQLWMRLSG--------------ALQKKRNSELSY------RE 143
S K+R L GIP +R ++W G A K+R LS E
Sbjct: 111 SRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENE 170
Query: 144 IVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQG 203
S+ D + + I+ D+ RT P N C G L +L A P++GY QG
Sbjct: 171 DAGFSAADREASLELIKLDISRTFP-NLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQG 229
Query: 204 TGMVAACLLLFLEEEDAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLD 263
+AA L+L L+ DAF S ++ ++F + T + LP+L
Sbjct: 230 MSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLF 289
Query: 264 KLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEE 323
+++++ + + W T ++ + + L RIWD+F +G LF+ LG+L L E+
Sbjct: 290 AHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKL-FED 348
Query: 324 LIQSENSASIFNTLSDIPSQMEDAELLLGVA 354
++ + + L+ +P + EL +A
Sbjct: 349 ILTKMDFIHMAQFLTRLPEDLPAEELFASIA 379
>gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 85.5 bits (210), Expect = 2e-16
Identities = 69/271 (25%), Positives = 116/271 (42%), Gaps = 22/271 (8%)
Query: 104 SEKLRSLVLAGIPHGMRPQLWMRLSG--------------ALQKKRNSELSY------RE 143
S K+R L GIP +R ++W G A K+R LS E
Sbjct: 391 SRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENE 450
Query: 144 IVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQG 203
S+ D + + I+ D+ RT P N C G L +L A P++GY QG
Sbjct: 451 DAGFSAADREASLELIKLDISRTFP-NLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQG 509
Query: 204 TGMVAACLLLFLEEEDAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLD 263
+AA L+L L+ DAF S ++ ++F + T + LP+L
Sbjct: 510 MSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLF 569
Query: 264 KLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEE 323
+++++ + + W T ++ + + L RIWD+F +G LF+ LG+L L E+
Sbjct: 570 AHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKL-FED 628
Query: 324 LIQSENSASIFNTLSDIPSQMEDAELLLGVA 354
++ + + L+ +P + EL +A
Sbjct: 629 ILTKMDFIHMAQFLTRLPEDLPAEELFASIA 659
>gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 85.5 bits (210), Expect = 2e-16
Identities = 69/271 (25%), Positives = 116/271 (42%), Gaps = 22/271 (8%)
Query: 104 SEKLRSLVLAGIPHGMRPQLWMRLSG--------------ALQKKRNSELSY------RE 143
S K+R L GIP +R ++W G A K+R LS E
Sbjct: 391 SRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENE 450
Query: 144 IVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQG 203
S+ D + + I+ D+ RT P N C G L +L A P++GY QG
Sbjct: 451 DAGFSAADREASLELIKLDISRTFP-NLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQG 509
Query: 204 TGMVAACLLLFLEEEDAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLD 263
+AA L+L L+ DAF S ++ ++F + T + LP+L
Sbjct: 510 MSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLF 569
Query: 264 KLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEE 323
+++++ + + W T ++ + + L RIWD+F +G LF+ LG+L L E+
Sbjct: 570 AHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKL-FED 628
Query: 324 LIQSENSASIFNTLSDIPSQMEDAELLLGVA 354
++ + + L+ +P + EL +A
Sbjct: 629 ILTKMDFIHMAQFLTRLPEDLPAEELFASIA 659
>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
Length = 775
Score = 76.3 bits (186), Expect = 1e-13
Identities = 62/269 (23%), Positives = 112/269 (41%), Gaps = 20/269 (7%)
Query: 104 SEKLRSLVLAGIPHGMRPQLWMRLSGA------------LQKKRNSELSYREIVKNSSN- 150
+ ++R L G+P +R ++W G L + + S+ E +
Sbjct: 474 TRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDTE 533
Query: 151 -----DETIAAKQIEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTG 205
D + + I+ D+ RT PS F G L +L A P++GY QG
Sbjct: 534 GVSVADREASLELIKLDISRTFPSLYIFQKGGPYH-DVLHSILGAYTCYRPDVGYVQGMS 592
Query: 206 MVAACLLLFLEEEDAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKL 265
+AA L+L LEE DAF + ++ ++F + + L +L
Sbjct: 593 FIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLH 652
Query: 266 LQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELI 325
+ + + + + W T ++ + + L R+WD+F +G LF+ LG+L L E+ L+
Sbjct: 653 FKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILL 712
Query: 326 QSENSASIFNTLSDIPSQMEDAELLLGVA 354
Q + I L+ +P + +L +A
Sbjct: 713 QMD-FIHIAQFLTKLPEDITSEKLFSCIA 740
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,892,893
Number of Sequences: 37866
Number of extensions: 1230392
Number of successful extensions: 3382
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 181
Number of HSP's successfully gapped in prelim test: 90
Number of HSP's that attempted gapping in prelim test: 2956
Number of HSP's gapped (non-prelim): 397
length of query: 749
length of database: 18,247,518
effective HSP length: 110
effective length of query: 639
effective length of database: 14,082,258
effective search space: 8998562862
effective search space used: 8998562862
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.