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Search of human proteins with 29029597
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
(980 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29029597 glutamate receptor KA2 precursor [Homo sapiens] 1957 0.0
gi|29029595 glutamate receptor KA1 precursor [Homo sapiens] 1311 0.0
gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ... 725 0.0
gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor ... 709 0.0
gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2 ... 708 0.0
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ... 706 0.0
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p... 691 0.0
gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2 p... 528 e-150
gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1 p... 528 e-149
gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [H... 521 e-148
gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [H... 521 e-147
gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2 pr... 508 e-143
gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [H... 507 e-143
gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1 pre... 507 e-143
gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1 p... 500 e-141
gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2 p... 499 e-141
gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens] 301 2e-81
gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [H... 298 2e-80
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 251 2e-66
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 241 2e-63
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 241 2e-63
gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor ... 186 9e-47
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ... 179 1e-44
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ... 179 1e-44
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr... 179 1e-44
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [... 172 1e-42
gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor ... 166 1e-40
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat... 146 1e-34
gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate... 144 4e-34
gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3 p... 86 1e-16
>gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
Length = 980
Score = 1957 bits (5071), Expect = 0.0
Identities = 980/980 (100%), Positives = 980/980 (100%)
Query: 1 MPAELLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAK 60
MPAELLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAK
Sbjct: 1 MPAELLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAK 60
Query: 61 ARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKV 120
ARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKV
Sbjct: 61 ARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKV 120
Query: 121 GPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRG 180
GPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRG
Sbjct: 121 GPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRG 180
Query: 181 FLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFY 240
FLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFY
Sbjct: 181 FLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFY 240
Query: 241 KYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGP 300
KYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGP
Sbjct: 241 KYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGP 300
Query: 301 ALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTG 360
ALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTG
Sbjct: 301 ALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTG 360
Query: 361 RVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVT 420
RVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVT
Sbjct: 361 RVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVT 420
Query: 421 TILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGS 480
TILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGS
Sbjct: 421 TILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGS 480
Query: 481 WTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLD 540
WTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLD
Sbjct: 481 WTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLD 540
Query: 541 PFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPV 600
PFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPV
Sbjct: 541 PFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPV 600
Query: 601 GGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLAD 660
GGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLAD
Sbjct: 601 GGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLAD 660
Query: 661 QTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFL 720
QTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFL
Sbjct: 661 QTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFL 720
Query: 721 LESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKR 780
LESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKR
Sbjct: 721 LESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKR 780
Query: 781 KWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVS 840
KWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVS
Sbjct: 781 KWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVS 840
Query: 841 VCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAG 900
VCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAG
Sbjct: 841 VCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAG 900
Query: 901 SAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGVPAEA 960
SAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGVPAEA
Sbjct: 901 SAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGVPAEA 960
Query: 961 TSPPRPRPGPAGPRELAEHE 980
TSPPRPRPGPAGPRELAEHE
Sbjct: 961 TSPPRPRPGPAGPRELAEHE 980
>gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
Length = 956
Score = 1311 bits (3393), Expect = 0.0
Identities = 662/947 (69%), Positives = 766/947 (80%), Gaps = 24/947 (2%)
Query: 3 AELLLL---LIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPA 59
A L+LL L++ SP SLR+AAILDD C RGERL++ LA+ +IN E
Sbjct: 6 APLVLLPAWLVMVACSPH-----SLRIAAILDDPMECSRGERLSITLAKNRINRAPERLG 60
Query: 60 KARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIK 119
KA+VEVDIFEL RDS+YET +TMCQILPKGVV+VLGPSSSPAS+S +S+ICGEKE+PH K
Sbjct: 61 KAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFK 120
Query: 120 VGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVR 179
V PEE + Q+ RF +++L+PSN D+S+AV+ IL FN +A LICAKAECLL LE+L+R
Sbjct: 121 VAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLR 180
Query: 180 GFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAF 239
FLISK+TLSVRMLDD+RDPTPLLKEIRDDK +TIII ANAS+SH IL KA+ELGM SA+
Sbjct: 181 QFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAY 240
Query: 240 YKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLG 299
Y YI T ++F + +D +V+D NILGFS+FN SH F+ EF +SLN SW+ENC+ + G
Sbjct: 241 YTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTG 300
Query: 300 PALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLT 359
PALS+AL+FDAV+ VV+AV+ELNRSQEIGVKPL+C SA IW HGTSLMNYLRMVE +GLT
Sbjct: 301 PALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLT 360
Query: 360 GRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVV 419
G +EFNSKGQR+NY L+IL+ +R G R+IG W+ L+M++ N+S TL N TLVV
Sbjct: 361 GHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVV 420
Query: 420 TTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNG 479
TTILENPY+M + N Q + GN+R+EGFCVDML+ELAE+LRF Y++RLV DG+YG PE NG
Sbjct: 421 TTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANG 480
Query: 480 SWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFL 539
+WTGMVGELI RKADLAVA TITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFL
Sbjct: 481 TWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFL 540
Query: 540 DPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFP 599
DPFSP VWLFMLLAYLAVSCVLFL ARL+PYEWY+PHPC + R ++L NQY+LGNSLWFP
Sbjct: 541 DPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFP 600
Query: 600 VGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLA 659
VGGFMQQGS I PRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRM+VP+ES DDLA
Sbjct: 601 VGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLA 660
Query: 660 DQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAF 719
DQT IEYGTIH GS+MTFFQNSRYQTYQRMWNYM SKQPSVFVKSTEEGIARVLNS YAF
Sbjct: 661 DQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAF 720
Query: 720 LLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILK 779
LLESTMNEY+R+ NCNLTQIGGLLDTKGYGIGMP+GS FRDE LAILQLQENNRLEILK
Sbjct: 721 LLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILK 780
Query: 780 RKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEV 839
RKWWEGG+CPKEEDHRAKGLGMENIGGIF+VLICGLI+A+F+A++EF+W+ R S E+ EV
Sbjct: 781 RKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHS-EATEV 839
Query: 840 SVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALL--SLRAVREMRLSNGKLYSAGAGG 897
SVCQEM+ ELR + C+ + RRRR P R + R LSNGKL AG
Sbjct: 840 SVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPD 899
Query: 898 DAGSAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRA 944
QRL + CTH+RVC ECRR Q LRA
Sbjct: 900 QLA------QRLAQEAA-------LVARGCTHIRVCPECRRFQGLRA 933
>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
precursor [Homo sapiens]
Length = 908
Score = 725 bits (1871), Expect = 0.0
Identities = 399/879 (45%), Positives = 552/879 (62%), Gaps = 29/879 (3%)
Query: 5 LLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRG-ERLALALAREQINGIIEVPAKARV 63
LL LL + ++ + VL R I + G E LA A IN + +
Sbjct: 20 LLCLLWIGYSQGTTHVL---RFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTL 76
Query: 64 EVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPE 123
D ++ +E + C L GV ++ GPS S +SA+ V IC +PHI+ +
Sbjct: 77 TYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHS-SSANAVQSICNALGVPHIQTRWK 135
Query: 124 ETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLI 183
F VSLYP +S A+ +++ F + + +++ + L+RL+EL++
Sbjct: 136 HQVSDNKDSFY-VSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSR 194
Query: 184 SKETLSVRMLD-DSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKY 242
L +R L D++D PLLKE++ K +I D + ++ IL++A +GM + +Y Y
Sbjct: 195 YNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHY 254
Query: 243 ILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPAL 302
I TT+D L ++ N+ GF + NT + + +M E +A L
Sbjct: 255 IFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSM---ERLQAPPKPDSGL 311
Query: 303 -------SAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEY 355
AALM+DAVHVV AV++ ++ V L C W GT M+ ++ +
Sbjct: 312 LDGFMTTDAALMYDAVHVVSVAVQQF---PQMTVSSLQCNRHKPWRFGTRFMSLIKEAHW 368
Query: 356 DGLTGRVEFN-SKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLD--INLSQTL 412
+GLTGR+ FN + G RT++ L ++ +G +IG W L M + N++ +L
Sbjct: 369 EGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSL 428
Query: 413 ANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLY 472
+N++L+VTTILE PYV+ + + + L GN+RFEG+C+D+LREL+ +L F Y +RLVEDG Y
Sbjct: 429 SNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKY 488
Query: 473 GAPEP-NGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGR 531
GA + NG W GMV ELI+ KADLAVA IT REKVIDFSKPFMTLGISILYR G
Sbjct: 489 GAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGT 548
Query: 532 KPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYT 591
PG FSFL+P SP +W+++LLAYL VSCVLF+ AR SPYEWYNPHPC ++EN +T
Sbjct: 549 NPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPC-NPDSDVVENNFT 607
Query: 592 LGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVP 651
L NS WF VG MQQGSE+MP+ALSTR V G+WW FTLIIISSYTANLAAFLTV+RME P
Sbjct: 608 LLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESP 667
Query: 652 VESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIAR 711
++SADDLA QT IEYG + G+TMTFF+ S+ TY +MW +M S++ SV VKS EEGI R
Sbjct: 668 IDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQR 727
Query: 712 VLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQE 771
VL S YAFL+EST E+ + NCNLTQIGGL+D+KGYG+G P+GSP+RD+IT+AILQLQE
Sbjct: 728 VLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQE 787
Query: 772 NNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTR 831
+L ++K KWW G CP+EE A LG++NIGGIFIVL GL+++VFVAV EF++ ++
Sbjct: 788 EGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSK 847
Query: 832 RSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGP 870
++A+ E+ S C M++ELR ++ C++ R + +P P
Sbjct: 848 KNAQLEKRSFCSAMVEELRMSLKCQR----RLKHKPQAP 882
>gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
[Homo sapiens]
Length = 919
Score = 709 bits (1831), Expect = 0.0
Identities = 375/828 (45%), Positives = 531/828 (64%), Gaps = 15/828 (1%)
Query: 66 DIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEET 125
DI + +E T C L GVV++ GPS + + V IC E+PHI++ +
Sbjct: 82 DIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCT-NAVQSICNALEVPHIQLRWKHH 140
Query: 126 PRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISK 185
P L V+LYP +S A+ +++ + SA+++ + L+RL+EL+
Sbjct: 141 P-LDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYN 199
Query: 186 ETLSVRMLD-DSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYIL 244
L +R L DS D PLLKE++ + II D + +++ IL++A +GM + +Y +I
Sbjct: 200 IRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIF 259
Query: 245 TTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRE---NCEASTYLGPA 301
TT+D L L+ N+ GF + N +P V +M + E+ G
Sbjct: 260 TTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVM 319
Query: 302 LS-AALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTG 360
++ AAL++DAVH+V + R+ ++ V L C W G MN+++ +++GLTG
Sbjct: 320 MTDAALLYDAVHIVSVCYQ---RAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTG 376
Query: 361 RVEFN-SKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMN--ATTLDINLSQTLANKTL 417
R+ FN + G RT++ L I+ G ++GVW L + A N++ +L N++L
Sbjct: 377 RIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSL 436
Query: 418 VVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEP 477
+VTT+LE P+VM R + + L GN+RFEG+C+D+L+ELA +L F Y +RLVEDG YGA +
Sbjct: 437 IVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDD 496
Query: 478 NGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS 537
G W GMV ELI+ KADLAVA TIT REK IDFSKPFMTLG+SILYR G P FS
Sbjct: 497 KGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFS 556
Query: 538 FLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLW 597
FL+P SP +W+++LLAYL VSCVLF+ AR SPYEWY+ HPC ++EN +TL NS W
Sbjct: 557 FLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPC-NPGSEVVENNFTLLNSFW 615
Query: 598 FPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADD 657
F +G MQQGSE+MP+ALSTR + G+WW FTLIIISSYTANLAAFLTV+RME P++SADD
Sbjct: 616 FGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD 675
Query: 658 LADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRY 717
LA QT IEYG + G+TMTFF+ S+ T+++MW +M SK PS VK+ EEGI R L + Y
Sbjct: 676 LAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSK-PSALVKNNEEGIQRALTADY 734
Query: 718 AFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEI 777
A L+EST EY + NCNLTQIGGL+D+KGYGIG P+GSP+RD+IT+AILQLQE ++L I
Sbjct: 735 ALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHI 794
Query: 778 LKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESE 837
+K KWW G CP+EE+ A LG++ IGGIFIVL GL+++V VAV EF++ R++AE E
Sbjct: 795 MKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAERE 854
Query: 838 EVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRL 885
+ S C + E+R +++C++ + + + + A++++ + RL
Sbjct: 855 QRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRL 902
>gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2
precursor [Homo sapiens]
Length = 869
Score = 708 bits (1827), Expect = 0.0
Identities = 390/849 (45%), Positives = 535/849 (63%), Gaps = 25/849 (2%)
Query: 5 LLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRG-ERLALALAREQINGIIEVPAKARV 63
LL LL + ++ + VL R I + G E LA A IN + +
Sbjct: 20 LLCLLWIGYSQGTTHVL---RFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTL 76
Query: 64 EVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPE 123
D ++ +E + C L GV ++ GPS S +SA+ V IC +PHI+ +
Sbjct: 77 TYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHS-SSANAVQSICNALGVPHIQTRWK 135
Query: 124 ETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLI 183
F VSLYP +S A+ +++ F + + +++ + L+RL+EL++
Sbjct: 136 HQVSDNKDSFY-VSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSR 194
Query: 184 SKETLSVRMLD-DSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKY 242
L +R L D++D PLLKE++ K +I D + ++ IL++A +GM + +Y Y
Sbjct: 195 YNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHY 254
Query: 243 ILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPAL 302
I TT+D L ++ N+ GF + NT + + +M E +A L
Sbjct: 255 IFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSM---ERLQAPPKPDSGL 311
Query: 303 -------SAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEY 355
AALM+DAVHVV AV++ ++ V L C W GT M+ ++ +
Sbjct: 312 LDGFMTTDAALMYDAVHVVSVAVQQF---PQMTVSSLQCNRHKPWRFGTRFMSLIKEAHW 368
Query: 356 DGLTGRVEFN-SKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLD--INLSQTL 412
+GLTGR+ FN + G RT++ L ++ +G +IG W L M + N++ +L
Sbjct: 369 EGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSL 428
Query: 413 ANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLY 472
+N++L+VTTILE PYV+ + + + L GN+RFEG+C+D+LREL+ +L F Y +RLVEDG Y
Sbjct: 429 SNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKY 488
Query: 473 GAPEP-NGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGR 531
GA + NG W GMV ELI+ KADLAVA IT REKVIDFSKPFMTLGISILYR G
Sbjct: 489 GAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGT 548
Query: 532 KPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYT 591
PG FSFL+P SP +W+++LLAYL VSCVLF+ AR SPYEWYNPHPC ++EN +T
Sbjct: 549 NPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPC-NPDSDVVENNFT 607
Query: 592 LGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVP 651
L NS WF VG MQQGSE+MP+ALSTR V G+WW FTLIIISSYTANLAAFLTV+RME P
Sbjct: 608 LLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESP 667
Query: 652 VESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIAR 711
++SADDLA QT IEYG + G+TMTFF+ S+ TY +MW +M S++ SV VKS EEGI R
Sbjct: 668 IDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQR 727
Query: 712 VLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQE 771
VL S YAFL+EST E+ + NCNLTQIGGL+D+KGYG+G P+GSP+RD+IT+AILQLQE
Sbjct: 728 VLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQE 787
Query: 772 NNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTR 831
+L ++K KWW G CP+EE A LG++NIGGIFIVL GL+++VFVAV EF++ ++
Sbjct: 788 EGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSK 847
Query: 832 RSAESEEVS 840
++A+ E+ S
Sbjct: 848 KNAQLEKES 856
>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
precursor [Homo sapiens]
Length = 905
Score = 706 bits (1823), Expect = 0.0
Identities = 378/843 (44%), Positives = 530/843 (62%), Gaps = 22/843 (2%)
Query: 40 ERLALALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSS 99
E LA A IN + + DI + +E + C L GV ++ GPS S
Sbjct: 54 EELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHS 113
Query: 100 PASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYP 159
+S S V IC E+PHI+ + P + ++LYP +S A+ ++ +N+
Sbjct: 114 -SSVSAVQSICNALEVPHIQTRWKH-PSVDNKDLFYINLYPDYAAISRAILDLVLYYNWK 171
Query: 160 SASLICAKAECLLRLEELVRGFLISKETLSVRMLDD-SRDPTPLLKEIRDDKVSTIIIDA 218
+ +++ + L+RL+EL++ + +R L ++D PLLKE++ K +I D
Sbjct: 172 TVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDC 231
Query: 219 NASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYP 278
+ + IL++ +GM + +Y Y TT+D L L+ N+ GF + N +P
Sbjct: 232 SHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVS 291
Query: 279 EFVRSLNMSWRENCEASTYLGPAL-------SAALMFDAVHVVVSAVRELNRSQEIGVKP 331
+ +M E +A L AALM+DAV++V A +R+ ++ V
Sbjct: 292 SIIEKWSM---ERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIAS---HRASQLTVSS 345
Query: 332 LACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFN-SKGQRTNYTLRILEKSRQGHREIGV 390
L C W G MN ++ +DGLTG + FN + G R ++ L I+ +G +IG+
Sbjct: 346 LQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKIGI 405
Query: 391 WYSNRTLAMNATTLD--INLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCV 448
W SN L M + D N++ +LAN+TL+VTTILE PYVM R + + L GN+RFEG+C+
Sbjct: 406 WNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCL 465
Query: 449 DMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITAEREK 508
D+L+EL+ +L F Y ++LV DG YGA G W GMV ELI+ +ADLAVA TIT REK
Sbjct: 466 DLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREK 525
Query: 509 VIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLS 568
VIDFSKPFMTLGISILYR G PG FSFL+P SP +W+++LLA L VSCVLF+ AR +
Sbjct: 526 VIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFT 585
Query: 569 PYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFT 628
PYEWYNPHPC ++EN +TL NS WF VG MQQGSE+MP+ALSTR V G+WW FT
Sbjct: 586 PYEWYNPHPC-NPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFT 644
Query: 629 LIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQR 688
LIIISSYTANLAAFLTV+RME P++SADDLA QT IEYG + GSTMTFF+ S+ TY++
Sbjct: 645 LIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEK 704
Query: 689 MWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGY 748
MW +M S+Q + V++++EGI RVL + YA L+EST EY + NCNLTQIGGL+D+KGY
Sbjct: 705 MWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGY 764
Query: 749 GIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIF 808
G+G P+GSP+RD+IT+AILQLQE +L ++K KWW G CP+E++ A LG+ENIGGIF
Sbjct: 765 GVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIF 824
Query: 809 IVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPG 868
IVL GL+++VFVA+ EFI+ +R++ + E+ +++EL +S + + +++ R
Sbjct: 825 IVLAAGLVLSVFVAIGEFIYKSRKNNDIEQCLSFNAIMEEL--GISLKNQKKIKKKSRTK 882
Query: 869 GPS 871
G S
Sbjct: 883 GKS 885
>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
precursor [Homo sapiens]
Length = 918
Score = 691 bits (1783), Expect = 0.0
Identities = 372/825 (45%), Positives = 516/825 (62%), Gaps = 35/825 (4%)
Query: 40 ERLALALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSS 99
E LA A IN + + DI + +E + C L GV ++ GPS S
Sbjct: 54 EELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHS 113
Query: 100 PASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYP 159
+S S V IC E+PHI+ + P + ++LYP +S A+ ++ +N+
Sbjct: 114 -SSVSAVQSICNALEVPHIQTRWKH-PSVDNKDLFYINLYPDYAAISRAILDLVLYYNWK 171
Query: 160 SASLICAKAECLLRLEELVRGFLISKETLSVRMLDD-SRDPTPLLKEIRDDKVSTIIIDA 218
+ +++ + L+RL+EL++ + +R L ++D PLLKE++ K +I D
Sbjct: 172 TVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDC 231
Query: 219 NASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYP 278
+ + IL++ +GM + +Y Y TT+D L L+ N+ GF + N +P
Sbjct: 232 SHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVS 291
Query: 279 EFVRSLNMSWRENCEASTYLGPAL-------SAALMFDAVHVVVSAVRELNRSQEIGVKP 331
+ +M E +A L AALM+DAV++V A +R+ ++ V
Sbjct: 292 SIIEKWSM---ERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIAS---HRASQLTVSS 345
Query: 332 LACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFN-SKGQRTNYTLRILEKSRQGH----- 385
L C W G MN ++ +DGLTG + FN + G R ++ L I+ +G
Sbjct: 346 LQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAG 405
Query: 386 ----------REIGVWYSNRTLAMNATTLD--INLSQTLANKTLVVTTILENPYVMRRPN 433
++IG+W SN L M + D N++ +LAN+TL+VTTILE PYVM R +
Sbjct: 406 EVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKS 465
Query: 434 FQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKA 493
+ L GN+RFEG+C+D+L+EL+ +L F Y ++LV DG YGA G W GMV ELI+ +A
Sbjct: 466 DKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRA 525
Query: 494 DLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLA 553
DLAVA TIT REKVIDFSKPFMTLGISILYR G PG FSFL+P SP +W+++LLA
Sbjct: 526 DLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLA 585
Query: 554 YLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPR 613
L VSCVLF+ AR +PYEWYNPHPC ++EN +TL NS WF VG MQQGSE+MP+
Sbjct: 586 CLGVSCVLFVIARFTPYEWYNPHPC-NPDSDVVENNFTLLNSFWFGVGALMQQGSELMPK 644
Query: 614 ALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGS 673
ALSTR V G+WW FTLIIISSYTANLAAFLTV+RME P++SADDLA QT IEYG + GS
Sbjct: 645 ALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGS 704
Query: 674 TMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLN 733
TMTFF+ S+ TY++MW +M S+Q + V++++EGI RVL + YA L+EST EY + N
Sbjct: 705 TMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRN 764
Query: 734 CNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEED 793
CNLTQIGGL+D+KGYG+G P+GSP+RD+IT+AILQLQE +L ++K KWW G CP+E++
Sbjct: 765 CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDN 824
Query: 794 HRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEE 838
A LG+ENIGGIFIVL GL+++VFVA+ EFI+ +R++ + E+
Sbjct: 825 KEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQ 869
>gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2
precursor [Homo sapiens]
Length = 894
Score = 528 bits (1361), Expect = e-150
Identities = 316/818 (38%), Positives = 459/818 (56%), Gaps = 56/818 (6%)
Query: 56 EVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEI 115
E P VD L + + T+ C +GV ++ G S +T++ CG
Sbjct: 66 EKPFHLNYHVD--HLDSSNSFSVTNAFCSQFSRGVYAIFG-FYDQMSMNTLTSFCGALHT 122
Query: 116 PHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLE 175
+ TP +P++ DV + + L K E + L
Sbjct: 123 SFV------TPS-----------FPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLY 165
Query: 176 ELVRGFLISKETL-------------SVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASI 222
+ RGF I + + SV + D ++ +++E+ + +ID
Sbjct: 166 DTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVER 225
Query: 223 SHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFV- 281
+ IL + LG S Y Y+L + F + L+ ++ +NI GF + N +P +F+
Sbjct: 226 INTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQ 285
Query: 282 RSLNMSWRENCEASTYLGPA-LSAALMFDAVHVVVSAVRELNR-----SQEIGVKPLACT 335
R + + RE EA P ++AL DA+ V+ A R L R S+
Sbjct: 286 RWVRLDEREFPEAKN--APLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLAN 343
Query: 336 SANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNR 395
A W G + L+MV+ G+TG ++F++ G+RTNYT+ + E G R+ G W
Sbjct: 344 PAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYE 403
Query: 396 TLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELA 455
+ N S + N+T+VVTTILE+PYVM + N + L GNER+EG+CVD+ E+A
Sbjct: 404 RFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIA 463
Query: 456 ELLRFRYRLRLVEDGLYGAPEPNGS-WTGMVGELINRKADLAVAAFTITAEREKVIDFSK 514
+ +R +Y+L +V DG YGA +P W GMVGEL+ +AD+AVA TIT RE+VIDFSK
Sbjct: 464 KHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSK 523
Query: 515 PFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWY- 573
PFM+LGISI+ + KPG FSFLDP + +W+ ++ AY+ VS VLFL +R SPYEW+
Sbjct: 524 PFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHL 583
Query: 574 ---NPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLI 630
N P P N++ + NSLWF +G FMQQG +I PR+LS R V GVWW FTLI
Sbjct: 584 EDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLI 643
Query: 631 IISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMW 690
IISSYTANLAAFLTV+RM P+ESA+DLA QT I YGT+ +GST FF+ S+ Y++MW
Sbjct: 644 IISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMW 703
Query: 691 NYMQSKQPSVFVKSTEEGIARVLNS--RYAFLLESTMNEY-HRRLNCNLTQIGGLLDTKG 747
+YM+S +PSVF K+T +G+ARV S ++AFLLESTMNEY +R C+ ++GG LD+KG
Sbjct: 704 SYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKG 763
Query: 748 YGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWW-EGGRCPK---EEDHRAKGLGMEN 803
YG+ P GS + + LA+L+L E L+ LK KWW + G C + + L + N
Sbjct: 764 YGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSN 823
Query: 804 IGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSV 841
+ G+F +L+ GL +A+ VA++EF + +R AES+ + +
Sbjct: 824 VAGVFYILVGGLGLAMMVALIEFCYKSR--AESKRMKL 859
>gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
precursor [Homo sapiens]
Length = 894
Score = 528 bits (1359), Expect = e-149
Identities = 316/818 (38%), Positives = 459/818 (56%), Gaps = 56/818 (6%)
Query: 56 EVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEI 115
E P VD L + + T+ C +GV ++ G S +T++ CG
Sbjct: 66 EKPFHLNYHVD--HLDSSNSFSVTNAFCSQFSRGVYAIFG-FYDQMSMNTLTSFCGALHT 122
Query: 116 PHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLE 175
+ TP +P++ DV + + L K E + L
Sbjct: 123 SFV------TPS-----------FPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLY 165
Query: 176 ELVRGFLISKETL-------------SVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASI 222
+ RGF I + + SV + D ++ +++E+ + +ID
Sbjct: 166 DTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVER 225
Query: 223 SHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFV- 281
+ IL + LG S Y Y+L + F + L+ ++ +NI GF + N +P +F+
Sbjct: 226 INTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQ 285
Query: 282 RSLNMSWRENCEASTYLGPA-LSAALMFDAVHVVVSAVRELNR-----SQEIGVKPLACT 335
R + + RE EA P ++AL DA+ V+ A R L R S+
Sbjct: 286 RWVRLDEREFPEAKN--APLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLAN 343
Query: 336 SANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNR 395
A W G + L+MV+ G+TG ++F++ G+RTNYT+ + E G R+ G W
Sbjct: 344 PAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYE 403
Query: 396 TLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELA 455
+ N S + N+T+VVTTILE+PYVM + N + L GNER+EG+CVD+ E+A
Sbjct: 404 RFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIA 463
Query: 456 ELLRFRYRLRLVEDGLYGAPEPNGS-WTGMVGELINRKADLAVAAFTITAEREKVIDFSK 514
+ +R +Y+L +V DG YGA +P W GMVGEL+ +AD+AVA TIT RE+VIDFSK
Sbjct: 464 KHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSK 523
Query: 515 PFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWY- 573
PFM+LGISI+ + KPG FSFLDP + +W+ ++ AY+ VS VLFL +R SPYEW+
Sbjct: 524 PFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHL 583
Query: 574 ---NPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLI 630
N P P N++ + NSLWF +G FMQQG +I PR+LS R V GVWW FTLI
Sbjct: 584 EDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLI 643
Query: 631 IISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMW 690
IISSYTANLAAFLTV+RM P+ESA+DLA QT I YGT+ +GST FF+ S+ Y++MW
Sbjct: 644 IISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMW 703
Query: 691 NYMQSKQPSVFVKSTEEGIARVLNS--RYAFLLESTMNEY-HRRLNCNLTQIGGLLDTKG 747
+YM+S +PSVF K+T +G+ARV S ++AFLLESTMNEY +R C+ ++GG LD+KG
Sbjct: 704 SYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKG 763
Query: 748 YGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWW-EGGRCPKEED---HRAKGLGMEN 803
YG+ P GS + LA+L+L E L+ LK KWW + G C ++ + L + N
Sbjct: 764 YGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSN 823
Query: 804 IGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSV 841
+ G+F +L+ GL +A+ VA++EF + +R AES+ + +
Sbjct: 824 VAGVFYILVGGLGLAMMVALIEFCYKSR--AESKRMKL 859
>gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [Homo
sapiens]
Length = 906
Score = 521 bits (1343), Expect = e-148
Identities = 312/833 (37%), Positives = 463/833 (55%), Gaps = 34/833 (4%)
Query: 58 PAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPH 117
P K ++DI + +E T C KGV ++ G + + ++ CG +
Sbjct: 52 PPKLLPQIDIVNIS--DSFEMTYRFCSQFSKGVYAIFG-FYERRTVNMLTSFCGALHVCF 108
Query: 118 IKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEEL 177
I Q++ + L P +D A+ I+ + + I L L+++
Sbjct: 109 ITPSFPVDTSNQFV----LQLRPELQD---ALISIIDHYKWQKFVYIYDADRGLSVLQKV 161
Query: 178 VRGFLISK-ETLSVRMLDDSRDPTPLL-KEIRDDKVSTIIIDANASISHLILRKASELGM 235
+ + +V +L + + +L +++ K +++D + + IL + +L
Sbjct: 162 LDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEK 221
Query: 236 TSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEAS 295
Y YIL + F + L+ E +N+ GF + N + + ++ S +
Sbjct: 222 NGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRV 281
Query: 296 TYLGPALSAALMFDAVHVVVSAVRELNR-----SQEIGVKPLACTSANIWPHGTSLMNYL 350
+ P ++AL +D V V+ A + L R S+ A W G + L
Sbjct: 282 DWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRAL 341
Query: 351 RMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINL-S 409
+ V ++GLTG V+FN KG+RTNYTL ++E G R+IG W + AT +
Sbjct: 342 QQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDN 401
Query: 410 QTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVED 469
++ N+T +VTTILE+PYVM + N GN+R+EG+CV++ E+A+ + + YRL +V D
Sbjct: 402 SSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSD 461
Query: 470 GLYGAPEPNG-SWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVH 528
G YGA +P+ +W GMVGEL+ +AD+AVA TIT RE+VIDFSKPFM+LGISI+ +
Sbjct: 462 GKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKP 521
Query: 529 MGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILE- 587
KPG FSFLDP + +W+ ++ AY+ VS VLFL +R SPYEW++ R
Sbjct: 522 QKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEE-FEEGRDQTTSD 580
Query: 588 --NQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTV 645
N++ + NSLWF +G FMQQG +I PR+LS R V GVWW FTLIIISSYTANLAAFLTV
Sbjct: 581 QSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV 640
Query: 646 QRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKST 705
+RM P+ESA+DLA QT I YGT+ AGST FF+ S+ +++MW YM+S +PSVFV++T
Sbjct: 641 ERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTT 700
Query: 706 EEGIARVLNS--RYAFLLESTMNEY-HRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEI 762
EEG+ RV S +YA+LLESTMNEY +R C+ ++GG LD+KGYGI P GS R+ +
Sbjct: 701 EEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPV 760
Query: 763 TLAILQLQENNRLEILKRKWW-EGGRCPK---EEDHRAKGLGMENIGGIFIVLICGLIIA 818
LA+L+L E L+ LK KWW + G C + + L + N+ G+F +LI GL +A
Sbjct: 761 NLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLA 820
Query: 819 VFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPS 871
+ VA++EF + + RS C Q + A+ +TS R G S
Sbjct: 821 MLVALIEFCYKS-RSESKRMKGFCLIPQQSINEAI---RTSTLPRNSGAGASS 869
>gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [Homo
sapiens]
Length = 906
Score = 521 bits (1341), Expect = e-147
Identities = 312/833 (37%), Positives = 463/833 (55%), Gaps = 34/833 (4%)
Query: 58 PAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPH 117
P K ++DI + +E T C KGV ++ G + + ++ CG +
Sbjct: 52 PPKLLPQIDIVNIS--DSFEMTYRFCSQFSKGVYAIFG-FYERRTVNMLTSFCGALHVCF 108
Query: 118 IKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEEL 177
I Q++ + L P +D A+ I+ + + I L L+++
Sbjct: 109 ITPSFPVDTSNQFV----LQLRPELQD---ALISIIDHYKWQKFVYIYDADRGLSVLQKV 161
Query: 178 VRGFLISK-ETLSVRMLDDSRDPTPLL-KEIRDDKVSTIIIDANASISHLILRKASELGM 235
+ + +V +L + + +L +++ K +++D + + IL + +L
Sbjct: 162 LDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEK 221
Query: 236 TSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEAS 295
Y YIL + F + L+ E +N+ GF + N + + ++ S +
Sbjct: 222 NGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRV 281
Query: 296 TYLGPALSAALMFDAVHVVVSAVRELNR-----SQEIGVKPLACTSANIWPHGTSLMNYL 350
+ P ++AL +D V V+ A + L R S+ A W G + L
Sbjct: 282 DWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRAL 341
Query: 351 RMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINL-S 409
+ V ++GLTG V+FN KG+RTNYTL ++E G R+IG W + AT +
Sbjct: 342 QQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDN 401
Query: 410 QTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVED 469
++ N+T +VTTILE+PYVM + N GN+R+EG+CV++ E+A+ + + YRL +V D
Sbjct: 402 SSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSD 461
Query: 470 GLYGAPEPNG-SWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVH 528
G YGA +P+ +W GMVGEL+ +AD+AVA TIT RE+VIDFSKPFM+LGISI+ +
Sbjct: 462 GKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKP 521
Query: 529 MGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILE- 587
KPG FSFLDP + +W+ ++ AY+ VS VLFL +R SPYEW++ R
Sbjct: 522 QKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEE-FEEGRDQTTSD 580
Query: 588 --NQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTV 645
N++ + NSLWF +G FMQQG +I PR+LS R V GVWW FTLIIISSYTANLAAFLTV
Sbjct: 581 QSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV 640
Query: 646 QRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKST 705
+RM P+ESA+DLA QT I YGT+ AGST FF+ S+ +++MW YM+S +PSVFV++T
Sbjct: 641 ERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTT 700
Query: 706 EEGIARVLNS--RYAFLLESTMNEY-HRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEI 762
EEG+ RV S +YA+LLESTMNEY +R C+ ++GG LD+KGYGI P GS R +
Sbjct: 701 EEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRGPV 760
Query: 763 TLAILQLQENNRLEILKRKWW-EGGRCPKEED---HRAKGLGMENIGGIFIVLICGLIIA 818
LA+L+L E L+ LK KWW + G C ++ + L + N+ G+F +LI GL +A
Sbjct: 761 NLAVLKLSEQGVLDKLKSKWWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLA 820
Query: 819 VFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPS 871
+ VA++EF + + RS C Q + A+ +TS R G S
Sbjct: 821 MLVALIEFCYKS-RSESKRMKGFCLIPQQSINEAI---RTSTLPRNSGAGASS 869
>gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2
precursor [Homo sapiens]
Length = 883
Score = 508 bits (1308), Expect = e-143
Identities = 300/805 (37%), Positives = 454/805 (56%), Gaps = 38/805 (4%)
Query: 62 RVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVG 121
R+ I L+ + + T+ C +GV ++ G S +T++ CG + I
Sbjct: 57 RLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFG-FYDKKSVNTITSFCGTLHVSFI--- 112
Query: 122 PEETPRLQYLRFASVSLYP----SNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEEL 177
TP F + +P D+ A+ +++ + + + + L L+ +
Sbjct: 113 ---TPS-----FPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAV 164
Query: 178 VRGFLISKETLSV----RMLDDSRDPT--PLLKEIRDDKVSTIIIDANASISHLILRKAS 231
+ K ++ + +D +D L +++ K +I+D + I+ +
Sbjct: 165 LDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVI 224
Query: 232 ELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWREN 291
+G Y YI+ + F L I +N+ GF + + +F+ + +
Sbjct: 225 TIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKE 284
Query: 292 CEASTYLGPALSAALMFDAVHVVVSAVRELNRSQ-EIGVKPLA----CTSANIWPHGTSL 346
+ ++AL +DAV V+ A R L + + EI + A A W G +
Sbjct: 285 YPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEI 344
Query: 347 MNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDI 406
L+ V+ +GL+G ++F+ G+R NYT+ I+E G R+IG W + + T L
Sbjct: 345 ERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPS 404
Query: 407 -NLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLR 465
N + L NKT+VVTTILE+PYVM + N + L GNER+EG+CVD+ E+A+ F+Y+L
Sbjct: 405 GNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLT 464
Query: 466 LVEDGLYGAPEPNGS-WTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISIL 524
+V DG YGA + + W GMVGEL+ KAD+A+A TIT RE+VIDFSKPFM+LGISI+
Sbjct: 465 IVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIM 524
Query: 525 YRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPH--PCLRAR 582
+ KPG FSFLDP + +W+ ++ AY+ VS VLFL +R SPYEW+ +
Sbjct: 525 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQ 584
Query: 583 PHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAF 642
N++ + NSLWF +G FM+QG +I PR+LS R V GVWW FTLIIISSYTANLAAF
Sbjct: 585 SSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAF 644
Query: 643 LTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFV 702
LTV+RM P+ESA+DL+ QT I YGT+ +GST FF+ S+ + +MW YM+S +PSVFV
Sbjct: 645 LTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFV 704
Query: 703 KSTEEGIARVLNS--RYAFLLESTMNEY-HRRLNCNLTQIGGLLDTKGYGIGMPLGSPFR 759
++T EG+ARV S +YA+LLESTMNEY +R C+ ++GG LD+KGYGI P GS R
Sbjct: 705 RTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLR 764
Query: 760 DEITLAILQLQENNRLEILKRKWW-EGGRCPK---EEDHRAKGLGMENIGGIFIVLICGL 815
+ + LA+L+L E L+ LK KWW + G C + + L + N+ G+F +L+ GL
Sbjct: 765 NAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGL 824
Query: 816 IIAVFVAVMEFIWSTRRSAESEEVS 840
+A+ VA++EF + +R A+ +V+
Sbjct: 825 GLAMLVALIEFCYKSRAEAKRMKVA 849
>gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [Homo
sapiens]
Length = 836
Score = 507 bits (1306), Expect = e-143
Identities = 300/805 (37%), Positives = 454/805 (56%), Gaps = 38/805 (4%)
Query: 62 RVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVG 121
R+ I L+ + + T+ C +GV ++ G S +T++ CG + I
Sbjct: 10 RLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFG-FYDKKSVNTITSFCGTLHVSFI--- 65
Query: 122 PEETPRLQYLRFASVSLYP----SNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEEL 177
TP F + +P D+ A+ +++ + + + + L L+ +
Sbjct: 66 ---TPS-----FPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAV 117
Query: 178 VRGFLISKETLSV----RMLDDSRDPT--PLLKEIRDDKVSTIIIDANASISHLILRKAS 231
+ K ++ + +D +D L +++ K +I+D + I+ +
Sbjct: 118 LDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVI 177
Query: 232 ELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWREN 291
+G Y YI+ + F L I +N+ GF + + +F+ + +
Sbjct: 178 TIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKE 237
Query: 292 CEASTYLGPALSAALMFDAVHVVVSAVRELNRSQ-EIGVKPLA----CTSANIWPHGTSL 346
+ ++AL +DAV V+ A R L + + EI + A A W G +
Sbjct: 238 YPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEI 297
Query: 347 MNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDI 406
L+ V+ +GL+G ++F+ G+R NYT+ I+E G R+IG W + + T L
Sbjct: 298 ERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPS 357
Query: 407 -NLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLR 465
N + L NKT+VVTTILE+PYVM + N + L GNER+EG+CVD+ E+A+ F+Y+L
Sbjct: 358 GNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLT 417
Query: 466 LVEDGLYGAPEPNGS-WTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISIL 524
+V DG YGA + + W GMVGEL+ KAD+A+A TIT RE+VIDFSKPFM+LGISI+
Sbjct: 418 IVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIM 477
Query: 525 YRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPH--PCLRAR 582
+ KPG FSFLDP + +W+ ++ AY+ VS VLFL +R SPYEW+ +
Sbjct: 478 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQ 537
Query: 583 PHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAF 642
N++ + NSLWF +G FM+QG +I PR+LS R V GVWW FTLIIISSYTANLAAF
Sbjct: 538 SSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAF 597
Query: 643 LTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFV 702
LTV+RM P+ESA+DL+ QT I YGT+ +GST FF+ S+ + +MW YM+S +PSVFV
Sbjct: 598 LTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFV 657
Query: 703 KSTEEGIARVLNS--RYAFLLESTMNEY-HRRLNCNLTQIGGLLDTKGYGIGMPLGSPFR 759
++T EG+ARV S +YA+LLESTMNEY +R C+ ++GG LD+KGYGI P GS R
Sbjct: 658 RTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLR 717
Query: 760 DEITLAILQLQENNRLEILKRKWW-EGGRCPKEED---HRAKGLGMENIGGIFIVLICGL 815
+ LA+L+L E L+ LK KWW + G C ++ + L + N+ G+F +L+ GL
Sbjct: 718 TPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGL 777
Query: 816 IIAVFVAVMEFIWSTRRSAESEEVS 840
+A+ VA++EF + +R A+ +V+
Sbjct: 778 GLAMLVALIEFCYKSRAEAKRMKVA 802
>gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1
precursor [Homo sapiens]
Length = 883
Score = 507 bits (1306), Expect = e-143
Identities = 300/805 (37%), Positives = 454/805 (56%), Gaps = 38/805 (4%)
Query: 62 RVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVG 121
R+ I L+ + + T+ C +GV ++ G S +T++ CG + I
Sbjct: 57 RLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFG-FYDKKSVNTITSFCGTLHVSFI--- 112
Query: 122 PEETPRLQYLRFASVSLYP----SNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEEL 177
TP F + +P D+ A+ +++ + + + + L L+ +
Sbjct: 113 ---TPS-----FPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAV 164
Query: 178 VRGFLISKETLSV----RMLDDSRDPT--PLLKEIRDDKVSTIIIDANASISHLILRKAS 231
+ K ++ + +D +D L +++ K +I+D + I+ +
Sbjct: 165 LDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVI 224
Query: 232 ELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWREN 291
+G Y YI+ + F L I +N+ GF + + +F+ + +
Sbjct: 225 TIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKE 284
Query: 292 CEASTYLGPALSAALMFDAVHVVVSAVRELNRSQ-EIGVKPLA----CTSANIWPHGTSL 346
+ ++AL +DAV V+ A R L + + EI + A A W G +
Sbjct: 285 YPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEI 344
Query: 347 MNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDI 406
L+ V+ +GL+G ++F+ G+R NYT+ I+E G R+IG W + + T L
Sbjct: 345 ERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPS 404
Query: 407 -NLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLR 465
N + L NKT+VVTTILE+PYVM + N + L GNER+EG+CVD+ E+A+ F+Y+L
Sbjct: 405 GNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLT 464
Query: 466 LVEDGLYGAPEPNGS-WTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISIL 524
+V DG YGA + + W GMVGEL+ KAD+A+A TIT RE+VIDFSKPFM+LGISI+
Sbjct: 465 IVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIM 524
Query: 525 YRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPH--PCLRAR 582
+ KPG FSFLDP + +W+ ++ AY+ VS VLFL +R SPYEW+ +
Sbjct: 525 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQ 584
Query: 583 PHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAF 642
N++ + NSLWF +G FM+QG +I PR+LS R V GVWW FTLIIISSYTANLAAF
Sbjct: 585 SSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAF 644
Query: 643 LTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFV 702
LTV+RM P+ESA+DL+ QT I YGT+ +GST FF+ S+ + +MW YM+S +PSVFV
Sbjct: 645 LTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFV 704
Query: 703 KSTEEGIARVLNS--RYAFLLESTMNEY-HRRLNCNLTQIGGLLDTKGYGIGMPLGSPFR 759
++T EG+ARV S +YA+LLESTMNEY +R C+ ++GG LD+KGYGI P GS R
Sbjct: 705 RTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLR 764
Query: 760 DEITLAILQLQENNRLEILKRKWW-EGGRCPKEED---HRAKGLGMENIGGIFIVLICGL 815
+ LA+L+L E L+ LK KWW + G C ++ + L + N+ G+F +L+ GL
Sbjct: 765 TPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGL 824
Query: 816 IIAVFVAVMEFIWSTRRSAESEEVS 840
+A+ VA++EF + +R A+ +V+
Sbjct: 825 GLAMLVALIEFCYKSRAEAKRMKVA 849
>gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1
precursor [Homo sapiens]
Length = 902
Score = 500 bits (1288), Expect = e-141
Identities = 308/845 (36%), Positives = 465/845 (55%), Gaps = 56/845 (6%)
Query: 41 RLALALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSP 100
RLA+ L N E P VD ++ + + T+ C +GV ++ G
Sbjct: 45 RLAIFLHNTSPNAS-EAPFNLVPHVD--NIETANSFAVTNAFCSQYSRGVFAIFGLYDK- 100
Query: 101 ASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPS 160
S T++ C I I Q++ + L PS L+ +L + +
Sbjct: 101 RSVHTLTSFCSALHISLITPSFPTEGESQFV----LQLRPSLRGALLS---LLDHYEW-- 151
Query: 161 ASLICAKAECLLRLEELVRGFLISKETL----------SVRMLDDSRDPT--PLLKEIRD 208
C + L + RG+ I + + S +++ D + LL+E+
Sbjct: 152 --------NCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDR 203
Query: 209 DKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFS 268
+ +ID IL + +G Y YI+ + F + L+ + +N+ GF
Sbjct: 204 RQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQ 263
Query: 269 MFNTSHPFYPEFV-RSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEI 327
+ + + P + + R + RE + T P ++AL +D V V+ R L R Q+I
Sbjct: 264 LVDFNTPMVIKLMDRWKKLDQREYPGSET--PPKYTSALTYDGVLVMAETFRSLRR-QKI 320
Query: 328 GVK------PLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKS 381
+ A W G + L+ V GLTG V+F+ G+R NYT+ + E
Sbjct: 321 DISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELK 380
Query: 382 RQGHREIGVW--YSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSG 439
G R++G W L + TL N + + N+T+VVTTI+E+PYVM + N + G
Sbjct: 381 STGPRKVGYWNDMDKLVLIQDVPTLG-NDTAAIENRTVVVTTIMESPYVMYKKNHEMFEG 439
Query: 440 NERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGS-WTGMVGELINRKADLAVA 498
N+++EG+CVD+ E+A+ + +Y++ +V DG YGA + + W GMVGEL+ KA++A+A
Sbjct: 440 NDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIA 499
Query: 499 AFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVS 558
TIT RE+VIDFSKPFM+LGISI+ + KPG FSFLDP + +W+ ++ AY+ VS
Sbjct: 500 PLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVS 559
Query: 559 CVLFLAARLSPYEWYNPHP--CLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALS 616
VLFL +R SPYEW+ P N++ + NSLWF +G FMQQG +I PR+LS
Sbjct: 560 VVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLS 619
Query: 617 TRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMT 676
R V GVWW FTLIIISSYTANLAAFLTV+RM P+ESA+DLA QT I YGT+ +GST
Sbjct: 620 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKE 679
Query: 677 FFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNS--RYAFLLESTMNEY-HRRLN 733
FF+ S+ Y++MW YM+S +PSVF ++T EG+ARV S ++AFLLESTMNEY +R
Sbjct: 680 FFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKP 739
Query: 734 CNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWW-EGGRC-PKE 791
C+ ++GG LD+KGYG+ P GS + LA+L+L E L+ LK KWW + G C PK+
Sbjct: 740 CDTMKVGGNLDSKGYGVATPKGSSLGTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKD 799
Query: 792 EDHRAK--GLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQEL 849
+ K L + N+ G+F +L+ GL +A+ VA++EF + +R A+ +++ + + +
Sbjct: 800 SGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSEAIRNKA 859
Query: 850 RHAVS 854
R +++
Sbjct: 860 RLSIT 864
>gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2
precursor [Homo sapiens]
Length = 884
Score = 499 bits (1285), Expect = e-141
Identities = 305/831 (36%), Positives = 456/831 (54%), Gaps = 56/831 (6%)
Query: 41 RLALALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSP 100
RLA+ L N E P VD ++ + + T+ C +GV ++ G
Sbjct: 45 RLAIFLHNTSPNAS-EAPFNLVPHVD--NIETANSFAVTNAFCSQYSRGVFAIFGLYDK- 100
Query: 101 ASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPS 160
S T++ C I I Q++ + L PS L+ +L + +
Sbjct: 101 RSVHTLTSFCSALHISLITPSFPTEGESQFV----LQLRPSLRGALLS---LLDHYEW-- 151
Query: 161 ASLICAKAECLLRLEELVRGFLISKETL----------SVRMLDDSRDPT--PLLKEIRD 208
C + L + RG+ I + + S +++ D + LL+E+
Sbjct: 152 --------NCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDR 203
Query: 209 DKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFS 268
+ +ID IL + +G Y YI+ + F + L+ + +N+ GF
Sbjct: 204 RQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQ 263
Query: 269 MFNTSHPFYPEFV-RSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEI 327
+ + + P + + R + RE + T P ++AL +D V V+ R L R Q+I
Sbjct: 264 LVDFNTPMVIKLMDRWKKLDQREYPGSET--PPKYTSALTYDGVLVMAETFRSLRR-QKI 320
Query: 328 GVK------PLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKS 381
+ A W G + L+ V GLTG V+F+ G+R NYT+ + E
Sbjct: 321 DISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELK 380
Query: 382 RQGHREIGVW--YSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSG 439
G R++G W L + TL N + + N+T+VVTTI+E+PYVM + N + G
Sbjct: 381 STGPRKVGYWNDMDKLVLIQDVPTLG-NDTAAIENRTVVVTTIMESPYVMYKKNHEMFEG 439
Query: 440 NERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGS-WTGMVGELINRKADLAVA 498
N+++EG+CVD+ E+A+ + +Y++ +V DG YGA + + W GMVGEL+ KA++A+A
Sbjct: 440 NDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIA 499
Query: 499 AFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVS 558
TIT RE+VIDFSKPFM+LGISI+ + KPG FSFLDP + +W+ ++ AY+ VS
Sbjct: 500 PLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVS 559
Query: 559 CVLFLAARLSPYEWYNPHP--CLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALS 616
VLFL +R SPYEW+ P N++ + NSLWF +G FMQQG +I PR+LS
Sbjct: 560 VVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLS 619
Query: 617 TRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMT 676
R V GVWW FTLIIISSYTANLAAFLTV+RM P+ESA+DLA QT I YGT+ +GST
Sbjct: 620 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKE 679
Query: 677 FFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNS--RYAFLLESTMNEY-HRRLN 733
FF+ S+ Y++MW YM+S +PSVF ++T EG+ARV S ++AFLLESTMNEY +R
Sbjct: 680 FFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKP 739
Query: 734 CNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWW-EGGRCPK-- 790
C+ ++GG LD+KGYG+ P GS + + LA+L+L E L+ LK KWW + G C
Sbjct: 740 CDTMKVGGNLDSKGYGVATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGG 799
Query: 791 -EEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVS 840
+ + L + N+ G+F +L+ GL +A+ VA++EF + +R A+ +V+
Sbjct: 800 GDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVA 850
>gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]
Length = 1007
Score = 301 bits (772), Expect = 2e-81
Identities = 184/557 (33%), Positives = 297/557 (53%), Gaps = 41/557 (7%)
Query: 302 LSAALMFDAVHVVVSAV-RELNRSQEIGVKPLACTSANI--WPHGTSLMNYLRMVEYDGL 358
+S ++D V ++ +A ++L + + L+C N W G S++ ++ GL
Sbjct: 322 ISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGL 381
Query: 359 TGRVEFNSKGQRTNYTLRIL-----EKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLA 413
TG +EF G N IL E+ +G R++G W N +N + D L +
Sbjct: 382 TGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCW--NPVTGLNGSLTDKKLENNMR 439
Query: 414 NKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYG 473
L V T+LE P+VM N L ++++GF +D+L L+ L F Y + + D YG
Sbjct: 440 GVVLRVVTVLEEPFVMVSEN--VLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYG 497
Query: 474 APEPNGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKP 533
+P+ +G+W G+VGEL+ ++AD+ ++A TIT +RE V+DF+ +M + +L R +
Sbjct: 498 SPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR-RAEKTV 556
Query: 534 GYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLG 593
F+ L PF ++W + L V +++L W NP P L+ TL
Sbjct: 557 DMFACLAPFDLSLWACIAGTVLLVGLLVYLL------NWLNP-PRLQMGSM---TSTTLY 606
Query: 594 NSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVE 653
NS+WF G F+QQG E+ L+TR + G WW F LI+ISSYTANLAAFLT+ R+E ++
Sbjct: 607 NSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQ 666
Query: 654 SADDLADQTNIEYGTIHAGSTM---------TFFQNSRYQTYQRMWNYMQSKQPSVFVKS 704
S DL+ QT I YGT+ + F ++S Y RM N + +V
Sbjct: 667 SLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVL--E 724
Query: 705 TEEGIARVLNSRYAFLLESTMNEY--HRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEI 762
++ GI +V YAF+ ++ + EY +C+ IG + +GYGI + GSP+RD
Sbjct: 725 SQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRDVF 784
Query: 763 TLAILQLQENNRLEILKRKWW-EGGRCP--KEEDHRAKG--LGMENIGGIFIVLICGLII 817
+ IL+LQ+N ++ILK KWW + G+C D + KG L +++ G+F +L G+++
Sbjct: 785 SQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVL 844
Query: 818 AVFVAVMEFIWSTRRSA 834
+ F+A++E W+ R+ +
Sbjct: 845 SCFIAMLETWWNKRKGS 861
>gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [Homo
sapiens]
Length = 1009
Score = 298 bits (762), Expect = 2e-80
Identities = 190/556 (34%), Positives = 287/556 (51%), Gaps = 39/556 (7%)
Query: 302 LSAALMFDAVHVVVSAV-RELNRSQEIGVKPLACT--SANIWPHGTSLMNYLRMVEYDGL 358
+S ++D+V ++ +A R+L + + L C S W G S+++ ++ GL
Sbjct: 318 ISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGL 377
Query: 359 TGRVEFNSKGQRTNYTLRIL-----EKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLA 413
TG +EF IL E + R++ W S + L N + + + L
Sbjct: 378 TGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGL--NGSLQERPMGSRLQ 435
Query: 414 NKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYG 473
TL V T+LE P+VM N L +R++GF +D+L LA+ L F+Y + DG YG
Sbjct: 436 GLTLKVVTVLEEPFVMVAENI--LGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYG 493
Query: 474 APEPNGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKP 533
N SW GM+GELI+++ADLA++A TIT ERE V+DFSK +M + IL + K
Sbjct: 494 HQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIK-KPEEKI 552
Query: 534 GYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYN---PHPCLRARPHILENQY 590
FS PF AVW + A V ++F+ R+ + P P A
Sbjct: 553 SIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASA--------- 603
Query: 591 TLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEV 650
TL +++W G F+QQG E +++ R V G WW FTLI+ SSYTANLAAFLTV RM+
Sbjct: 604 TLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDN 663
Query: 651 PVESADDLADQTNIEYGTIHAGSTMTFFQN------SRYQTYQRMWNYM-QSKQPSVFVK 703
P+ + DL+ Q + YGT+ + +F+ + T+ +W + ++ V
Sbjct: 664 PIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVS 723
Query: 704 STEEGIARVLNSRYAFLLESTMNEYHRRL--NCNLTQIGGLLDTKGYGIGMPLGSPFRDE 761
S EGI + YAFL + + EY +C++T IG + +KGYGI + GSP+RD
Sbjct: 724 SPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDL 783
Query: 762 ITLAILQLQENNRLEILKRKWW-EGGRCPKEEDHRA----KGLGMENIGGIFIVLICGLI 816
+ IL+LQ+ L++LK+KWW GRC A K L + + G+F +L GL+
Sbjct: 784 FSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLL 843
Query: 817 IAVFVAVMEFIWSTRR 832
+A VA +E W++ R
Sbjct: 844 LACLVAALELWWNSNR 859
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 251 bits (641), Expect = 2e-66
Identities = 206/752 (27%), Positives = 335/752 (44%), Gaps = 92/752 (12%)
Query: 196 SRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLD 255
+++ T LL E ++ + II+ A+ + + R A+ L MT + Y +++
Sbjct: 201 TKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLV----------- 249
Query: 256 GIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVV 315
G E S N L ++ P+ + L + +N +A + DAV VV
Sbjct: 250 GEREISGNALRYA---------PDGILGLQLINGKN-----------ESAHISDAVGVVA 289
Query: 316 SAVRELNRSQEIGVKPLACT-SANIWPHGTSLMNYLRMVEY-DGLTGRVEFNSKGQRTNY 373
AV EL + I P C + NIW G L +Y DG+TGRVEFN G R
Sbjct: 290 QAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFA 349
Query: 374 TLRILEKSRQGHREIGVWYSNRTLAMNATTL----DINLSQTLANKT-LVVTTILENPYV 428
I+ + ++G++ + + + + + T L + TI + P+V
Sbjct: 350 NYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFV 409
Query: 429 MRRPNFQALSGNERFE-------------------------------GFCVDMLRELAEL 457
+P + E F GFC+D+L +LA
Sbjct: 410 YVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLART 469
Query: 458 LRFRYRLRLVEDGLYGAPEP-NGS----WTGMVGELINRKADLAVAAFTITAEREKVIDF 512
+ F Y + LV DG +G E N S W GM+GEL++ +AD+ VA TI ER + I+F
Sbjct: 470 MNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEF 529
Query: 513 SKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEW 572
SKPF G++IL + + R SF+ PF +WL + L+ V+ +L+L R SP+
Sbjct: 530 SKPFKYQGLTILVKKEIPRST-LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGR 588
Query: 573 YNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQG-SEIMPRALSTRCVSGVWWAFTLII 631
+ + E+ TL +++WF G + G E PR+ S R + VW F +II
Sbjct: 589 FKVN-----SEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMII 643
Query: 632 ISSYTANLAAFLTVQRMEVPVESADD---LADQTNIEYGTIHAGSTMTFFQNSRYQTYQR 688
++SYTANLAAFL + R E + +D Y T+ S +F+ R
Sbjct: 644 VASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFR--RQVELST 701
Query: 689 MWNYMQSKQPSVFVKSTEEGIARVL-NSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKG 747
M+ +M+ +S E I V N +AF+ +S + E+ C+L G L G
Sbjct: 702 MYRHMEKHN----YESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSG 757
Query: 748 YGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGI 807
+GIGM SP++ ++L+IL+ EN +E L + W C + A L EN+ G+
Sbjct: 758 FGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPAT-LTFENMAGV 816
Query: 808 FIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRP 867
F+++ G++ +F+ +E + + A +++ + + R + RK+ R+ +
Sbjct: 817 FMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKK 876
Query: 868 GGPSRALLSLRAVREMRLSNGKLYSAGAGGDA 899
RA+ S A R + K S G G A
Sbjct: 877 KATFRAITSTLASSFKRRRSSKDTSTGGGRGA 908
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 241 bits (615), Expect = 2e-63
Identities = 192/694 (27%), Positives = 314/694 (45%), Gaps = 92/694 (13%)
Query: 196 SRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLD 255
+++ T LL E ++ + II+ A+ + + R A+ L MT + Y +++
Sbjct: 201 TKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLV----------- 249
Query: 256 GIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVV 315
G E S N L ++ P+ + L + +N +A + DAV VV
Sbjct: 250 GEREISGNALRYA---------PDGILGLQLINGKN-----------ESAHISDAVGVVA 289
Query: 316 SAVRELNRSQEIGVKPLACT-SANIWPHGTSLMNYLRMVEY-DGLTGRVEFNSKGQRTNY 373
AV EL + I P C + NIW G L +Y DG+TGRVEFN G R
Sbjct: 290 QAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFA 349
Query: 374 TLRILEKSRQGHREIGVWYSNRTLAMNATTL----DINLSQTLANKT-LVVTTILENPYV 428
I+ + ++G++ + + + + + T L + TI + P+V
Sbjct: 350 NYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFV 409
Query: 429 MRRPNFQALSGNERFE-------------------------------GFCVDMLRELAEL 457
+P + E F GFC+D+L +LA
Sbjct: 410 YVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLART 469
Query: 458 LRFRYRLRLVEDGLYGAPEP-NGS----WTGMVGELINRKADLAVAAFTITAEREKVIDF 512
+ F Y + LV DG +G E N S W GM+GEL++ +AD+ VA TI ER + I+F
Sbjct: 470 MNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEF 529
Query: 513 SKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEW 572
SKPF G++IL + + R SF+ PF +WL + L+ V+ +L+L R SP+
Sbjct: 530 SKPFKYQGLTILVKKEIPRST-LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGR 588
Query: 573 YNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQG-SEIMPRALSTRCVSGVWWAFTLII 631
+ + E+ TL +++WF G + G E PR+ S R + VW F +II
Sbjct: 589 FKVN-----SEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMII 643
Query: 632 ISSYTANLAAFLTVQRMEVPVESADD---LADQTNIEYGTIHAGSTMTFFQNSRYQTYQR 688
++SYTANLAAFL + R E + +D Y T+ S +F+ R
Sbjct: 644 VASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFR--RQVELST 701
Query: 689 MWNYMQSKQPSVFVKSTEEGIARVL-NSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKG 747
M+ +M+ +S E I V N +AF+ +S + E+ C+L G L G
Sbjct: 702 MYRHMEKHN----YESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSG 757
Query: 748 YGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGI 807
+GIGM SP++ ++L+IL+ EN +E L + W C + A L EN+ G+
Sbjct: 758 FGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPAT-LTFENMAGV 816
Query: 808 FIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSV 841
F+++ G++ +F+ +E + + A +++ +
Sbjct: 817 FMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQL 850
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 241 bits (615), Expect = 2e-63
Identities = 192/694 (27%), Positives = 314/694 (45%), Gaps = 92/694 (13%)
Query: 196 SRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLD 255
+++ T LL E ++ + II+ A+ + + R A+ L MT + Y +++
Sbjct: 201 TKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLV----------- 249
Query: 256 GIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVV 315
G E S N L ++ P+ + L + +N +A + DAV VV
Sbjct: 250 GEREISGNALRYA---------PDGILGLQLINGKN-----------ESAHISDAVGVVA 289
Query: 316 SAVRELNRSQEIGVKPLACT-SANIWPHGTSLMNYLRMVEY-DGLTGRVEFNSKGQRTNY 373
AV EL + I P C + NIW G L +Y DG+TGRVEFN G R
Sbjct: 290 QAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFA 349
Query: 374 TLRILEKSRQGHREIGVWYSNRTLAMNATTL----DINLSQTLANKT-LVVTTILENPYV 428
I+ + ++G++ + + + + + T L + TI + P+V
Sbjct: 350 NYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFV 409
Query: 429 MRRPNFQALSGNERFE-------------------------------GFCVDMLRELAEL 457
+P + E F GFC+D+L +LA
Sbjct: 410 YVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLART 469
Query: 458 LRFRYRLRLVEDGLYGAPEP-NGS----WTGMVGELINRKADLAVAAFTITAEREKVIDF 512
+ F Y + LV DG +G E N S W GM+GEL++ +AD+ VA TI ER + I+F
Sbjct: 470 MNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEF 529
Query: 513 SKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEW 572
SKPF G++IL + + R SF+ PF +WL + L+ V+ +L+L R SP+
Sbjct: 530 SKPFKYQGLTILVKKEIPRST-LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGR 588
Query: 573 YNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQG-SEIMPRALSTRCVSGVWWAFTLII 631
+ + E+ TL +++WF G + G E PR+ S R + VW F +II
Sbjct: 589 FKVN-----SEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMII 643
Query: 632 ISSYTANLAAFLTVQRMEVPVESADD---LADQTNIEYGTIHAGSTMTFFQNSRYQTYQR 688
++SYTANLAAFL + R E + +D Y T+ S +F+ R
Sbjct: 644 VASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFR--RQVELST 701
Query: 689 MWNYMQSKQPSVFVKSTEEGIARVL-NSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKG 747
M+ +M+ +S E I V N +AF+ +S + E+ C+L G L G
Sbjct: 702 MYRHMEKHN----YESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSG 757
Query: 748 YGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGI 807
+GIGM SP++ ++L+IL+ EN +E L + W C + A L EN+ G+
Sbjct: 758 FGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPAT-LTFENMAGV 816
Query: 808 FIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSV 841
F+++ G++ +F+ +E + + A +++ +
Sbjct: 817 FMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQL 850
>gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor
[Homo sapiens]
Length = 1336
Score = 186 bits (472), Expect = 9e-47
Identities = 220/901 (24%), Positives = 378/901 (41%), Gaps = 122/901 (13%)
Query: 2 PAELLLLLIVAFASPSCQVLSS----------------LRMAAILDDQTVCGRGERLALA 45
PA++LLLL +A ASP + L +A + RL A
Sbjct: 13 PAKMLLLLALACASPFPEEAPGPGGAGGPGGGLGGARPLNVALVFSGPAYAAEAARLGPA 72
Query: 46 LAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASAST 105
+A + ++V A V R + D + + GVV S +PA A
Sbjct: 73 VAAAVRSPGLDVRPVALVLNG--SDPRSLVLQLCDLLSGLRVHGVVFE-DDSRAPAVAPI 129
Query: 106 VSHICGEKEIPHIKVGPEE----TPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSA 161
+ + + +P + V TP+ + F + L S E + +L+ +++ S
Sbjct: 130 LDFLSAQTSLPIVAVHGGAALVLTPKEKGSTF--LQLGSSTEQQLQVIFEVLEEYDWTSF 187
Query: 162 SLICAKAE----CLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIID 217
+ +A L +E L G L+ E LD L ++R ++
Sbjct: 188 VAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLSAQLRSVSAQIRLLF 247
Query: 218 ANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFY 277
+ + R A E G+T + Y + + G + + G + P
Sbjct: 248 CAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPGGA------PLP 301
Query: 278 PEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSA 337
+ WR++ G A+ A + +R+ E+G C +
Sbjct: 302 AGLFAVRSAGWRDDLARRVAAGVAVVA-------RGAQALLRDYGFLPELGHD---CRAQ 351
Query: 338 NIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTL 397
N G SL Y + +D FN G N +L ++ +R E+ + +TL
Sbjct: 352 NRTHRGESLHRYFMNITWDNRD--YSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTL 409
Query: 398 AMNA---TTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGN-------------- 440
+ + L + L V T+ E P+V+ P +SG
Sbjct: 410 RLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPA-DPISGTCIRDSVPCRSQLNR 468
Query: 441 -------------ERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGE 487
+GFC+D+L+ LA + F Y L LV +G +G + +G W GM+GE
Sbjct: 469 THSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGK-KIDGVWNGMIGE 527
Query: 488 LINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSP 544
+ ++AD+A+ + TI ER +++DFS PF+ GIS++ + R G S FL+P+SP
Sbjct: 528 VFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVM----VARSNGTVSPSAFLEPYSP 583
Query: 545 AVWLFMLLAYLAVSCV-LFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGF 603
AVW+ M + L V V +F+ LSP YN RP + +T+G S+W
Sbjct: 584 AVWVMMFVMCLTVVAVTVFIFEYLSPV-GYNRSLATGKRPG--GSTFTIGKSIWLLWALV 640
Query: 604 MQQGSEI-MPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQ- 661
+ PR +++ + VW F +I ++SYTANLAAF+ E V++ L+D+
Sbjct: 641 FNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMI---QEEYVDTVSGLSDRK 697
Query: 662 --------TNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYM-QSKQPSVFVKSTEEGIARV 712
+++GT+ GST + + Y M +YM + QP V EE + ++
Sbjct: 698 FQRPQEQYPPLKFGTVPNGST----EKNIRSNYPDMHSYMVRYNQPRV-----EEALTQL 748
Query: 713 LNSRY-AFLLESTMNEYHRRLN--CNLTQIGG--LLDTKGYGIGMPLGSPFRDEITLAIL 767
+ AF+ ++ + Y R + C L IG + T GYGI + GS ++ I LA+L
Sbjct: 749 KAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALL 808
Query: 768 QLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFI 827
Q ++ +E+L+R W G + + + L ++N+ G+F + L++A+ ++++ F
Sbjct: 809 QFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYM----LLVAMGLSLLVFA 864
Query: 828 W 828
W
Sbjct: 865 W 865
>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
precursor [Homo sapiens]
Length = 1281
Score = 179 bits (454), Expect = 1e-44
Identities = 123/406 (30%), Positives = 207/406 (50%), Gaps = 34/406 (8%)
Query: 444 EGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTIT 503
+GFC+D+L++L+ ++F Y L LV +G +G + N W GM+GE++ ++A +AV + TI
Sbjct: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGK-KVNNVWNGMIGEVVYQRAVMAVGSLTIN 515
Query: 504 AEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPAVWLFMLLAYLAVSCV 560
ER +V+DFS PF+ GIS++ + R G S FL+PFS +VW+ M + L VS +
Sbjct: 516 EERSEVVDFSVPFVETGISVM----VSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAI 571
Query: 561 -LFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIM-PRALSTR 618
+F+ SP YN + PH +T+G ++W G + P+ +++
Sbjct: 572 AVFVFEYFSPV-GYNRNLAKGKAPH--GPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSK 628
Query: 619 CVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEY------GTIHAG 672
+ VW F +I ++SYTANLAAF+ + V D Q +Y GT+ G
Sbjct: 629 IMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNG 688
Query: 673 STMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRY-AFLLESTMNEYH-- 729
ST +N+ +Q M + Q K E+ + + + AF+ ++ + Y
Sbjct: 689 STERNIRNNYPYMHQYMTKFNQ--------KGVEDALVSLKTGKLDAFIYDAAVLNYKAG 740
Query: 730 RRLNCNLTQIGG--LLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGR 787
R C L IG + T GYGI + GSP++ +I LA+LQ + +E L+ W G
Sbjct: 741 RDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGIC 800
Query: 788 CPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVME--FIWSTR 831
++ + + L ++N+ G+F +L + +++ + E F W R
Sbjct: 801 HNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLR 846
>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 179 bits (454), Expect = 1e-44
Identities = 123/406 (30%), Positives = 207/406 (50%), Gaps = 34/406 (8%)
Query: 444 EGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTIT 503
+GFC+D+L++L+ ++F Y L LV +G +G + N W GM+GE++ ++A +AV + TI
Sbjct: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGK-KVNNVWNGMIGEVVYQRAVMAVGSLTIN 515
Query: 504 AEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPAVWLFMLLAYLAVSCV 560
ER +V+DFS PF+ GIS++ + R G S FL+PFS +VW+ M + L VS +
Sbjct: 516 EERSEVVDFSVPFVETGISVM----VSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAI 571
Query: 561 -LFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIM-PRALSTR 618
+F+ SP YN + PH +T+G ++W G + P+ +++
Sbjct: 572 AVFVFEYFSPV-GYNRNLAKGKAPH--GPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSK 628
Query: 619 CVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEY------GTIHAG 672
+ VW F +I ++SYTANLAAF+ + V D Q +Y GT+ G
Sbjct: 629 IMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNG 688
Query: 673 STMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRY-AFLLESTMNEYH-- 729
ST +N+ +Q M + Q K E+ + + + AF+ ++ + Y
Sbjct: 689 STERNIRNNYPYMHQYMTKFNQ--------KGVEDALVSLKTGKLDAFIYDAAVLNYKAG 740
Query: 730 RRLNCNLTQIGG--LLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGR 787
R C L IG + T GYGI + GSP++ +I LA+LQ + +E L+ W G
Sbjct: 741 RDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGIC 800
Query: 788 CPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVME--FIWSTR 831
++ + + L ++N+ G+F +L + +++ + E F W R
Sbjct: 801 HNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLR 846
>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 179 bits (454), Expect = 1e-44
Identities = 123/406 (30%), Positives = 207/406 (50%), Gaps = 34/406 (8%)
Query: 444 EGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTIT 503
+GFC+D+L++L+ ++F Y L LV +G +G + N W GM+GE++ ++A +AV + TI
Sbjct: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGK-KVNNVWNGMIGEVVYQRAVMAVGSLTIN 515
Query: 504 AEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPAVWLFMLLAYLAVSCV 560
ER +V+DFS PF+ GIS++ + R G S FL+PFS +VW+ M + L VS +
Sbjct: 516 EERSEVVDFSVPFVETGISVM----VSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAI 571
Query: 561 -LFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIM-PRALSTR 618
+F+ SP YN + PH +T+G ++W G + P+ +++
Sbjct: 572 AVFVFEYFSPV-GYNRNLAKGKAPH--GPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSK 628
Query: 619 CVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEY------GTIHAG 672
+ VW F +I ++SYTANLAAF+ + V D Q +Y GT+ G
Sbjct: 629 IMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNG 688
Query: 673 STMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRY-AFLLESTMNEYH-- 729
ST +N+ +Q M + Q K E+ + + + AF+ ++ + Y
Sbjct: 689 STERNIRNNYPYMHQYMTKFNQ--------KGVEDALVSLKTGKLDAFIYDAAVLNYKAG 740
Query: 730 RRLNCNLTQIGG--LLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGR 787
R C L IG + T GYGI + GSP++ +I LA+LQ + +E L+ W G
Sbjct: 741 RDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGIC 800
Query: 788 CPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVME--FIWSTR 831
++ + + L ++N+ G+F +L + +++ + E F W R
Sbjct: 801 HNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLR 846
>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor
[Homo sapiens]
Length = 1233
Score = 172 bits (436), Expect = 1e-42
Identities = 152/562 (27%), Positives = 249/562 (44%), Gaps = 62/562 (11%)
Query: 444 EGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTIT 503
+GFC+D+L++LA +++F Y L LV +G +G G W GM+GE+ ++AD+A+ + TI
Sbjct: 455 KGFCIDILKKLARVVKFSYDLYLVTNGKHGK-RVRGVWNGMIGEVYYKRADMAIGSLTIN 513
Query: 504 AEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPAVWLFMLLAYLAVSCV 560
ER +++DFS PF+ GIS++ + R G S FL+P+SPAVW+ M V C+
Sbjct: 514 EERSEIVDFSVPFVETGISVM----VARSNGTVSPSAFLEPYSPAVWVMMF-----VMCL 564
Query: 561 LFLAARLSPYEWYNP---HPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEI-MPRALS 616
+A + +E+++P + L +T+G S+W I PR +
Sbjct: 565 TVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTT 624
Query: 617 TRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQ------TNIEYGTIH 670
++ + VW F +I ++SYTANLAAF+ ++ V D Q +GT+
Sbjct: 625 SKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVP 684
Query: 671 AGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARV-LNSRYAFLLESTMNEY- 728
GST +++ + M + Q +S E+ + + + AF+ ++ + Y
Sbjct: 685 NGSTERNIRSNYRDMHTHMVKFNQ--------RSVEDALTSLKMGKLDAFIYDAAVLNYM 736
Query: 729 -HRRLNCNLTQIGG--LLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEG 785
+ C L IG + T GYGI M S ++ I LA+LQ + + L+ W G
Sbjct: 737 AGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSG 796
Query: 786 GRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFI--WSTRRSAESEEVSVCQ 843
++ + + L ++N+ G+F +L+ + +A+ V E + W R S + S
Sbjct: 797 ICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNS--SQLD 854
Query: 844 EMLQELRHAVSC----RKTSRSRRRRRP-----GGPSRALLSLRAVREMRLSNGKLYSAG 894
+L R SC + + R+ P + L L+A R+M + G S
Sbjct: 855 FLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAARDMVTTAGVSSSLD 914
Query: 895 AGGDAGSAHGGPQRLLDD---PGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGAPP 951
GG +R P P SG P PTP +G G P
Sbjct: 915 RATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEP----------SPTGWGPPD 964
Query: 952 RGLGVPAEATSPPRPRPGPAGP 973
G P RP GP
Sbjct: 965 GGRAALVRRAPQPPGRPPTPGP 986
>gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor
[Homo sapiens]
Length = 1484
Score = 166 bits (419), Expect = 1e-40
Identities = 115/408 (28%), Positives = 206/408 (50%), Gaps = 38/408 (9%)
Query: 444 EGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTIT 503
+GFC+D+L+++++ ++F Y L LV +G +G + NG+W GM+GE++ ++A +AV + TI
Sbjct: 458 KGFCIDILKKISKSVKFTYDLYLVTNGKHGK-KINGTWNGMIGEVVMKRAYMAVGSLTIN 516
Query: 504 AEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPAVWLFMLLAYLAVSCV 560
ER +V+DFS PF+ GIS++ + R G S FL+PFS VW+ M + L VS V
Sbjct: 517 EERSEVVDFSVPFIETGISVM----VSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAV 572
Query: 561 LFLAARLSPYEWYNP---HPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIM-PRALS 616
+E+++P + CL +T+G ++W G + P+ +
Sbjct: 573 AVFV-----FEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTT 627
Query: 617 TRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQ------TNIEYGTIH 670
++ + VW F +I ++SYTANLAAF+ + V D Q +GT+
Sbjct: 628 SKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVP 687
Query: 671 AGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRY-AFLLESTMNEY- 728
GST +N+ + + M + Q + ++ + + + AF+ ++ + Y
Sbjct: 688 NGSTERNIRNNYAEMHAYMGKFNQ--------RGVDDALLSLKTGKLDAFIYDAAVLNYM 739
Query: 729 -HRRLNCNLTQIGG--LLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEG 785
R C L IG + + GYGI + S ++ ++ LAILQL + +E L+ W G
Sbjct: 740 AGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTG 799
Query: 786 GRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVME--FIWSTR 831
++ + + L ++N+ G+F +L + +++ + E F W R
Sbjct: 800 ICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFR 847
>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate
3A [Homo sapiens]
Length = 1115
Score = 146 bits (368), Expect = 1e-34
Identities = 109/396 (27%), Positives = 191/396 (48%), Gaps = 32/396 (8%)
Query: 445 GFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITA 504
G+C+D+L ++AE + F + L +V DG YGA + NG WTG+VG+L+ A +AV +F+I
Sbjct: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWK-NGHWTGLVGDLLRGTAHMAVTSFSINT 636
Query: 505 EREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLA 564
R +VIDF+ PF + + IL R P +F+ P +WL + +A L ++ V
Sbjct: 637 ARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMWLGIFVA-LHITAVF--- 691
Query: 565 ARLSPYEWYNPH---PCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVS 621
L+ YEW +P P R R + L G + + P+ + R +
Sbjct: 692 --LTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFG---RTVAIKPPKCWTGRFLM 746
Query: 622 GVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLA---DQTNIEYGTIHAGSTMTFF 678
+W F + +S+YTANLAA + +++ + D +GT+ S +
Sbjct: 747 NLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYV 806
Query: 679 QNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRY---AFLLESTMNEYHRRL--N 733
+ Q++ M YM+ V +T +G+ + N AF+++ + +Y + +
Sbjct: 807 R----QSFPEMHEYMRRYN----VPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDAD 858
Query: 734 CNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEED 793
C L +G +GYGIG+P SP I+ I Q + + +++L KW+ C K
Sbjct: 859 CKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSF 918
Query: 794 HRAKGL--GMENIGGIFIVLICGLIIAVFVAVMEFI 827
+ L G+++ G+F++L G +++ + E I
Sbjct: 919 AVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHI 954
>gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
[Homo sapiens]
Length = 1043
Score = 144 bits (363), Expect = 4e-34
Identities = 150/583 (25%), Positives = 245/583 (42%), Gaps = 78/583 (13%)
Query: 445 GFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITA 504
G+C+D+L LAE F + L LV DG YGA +G WTG+VG+L+ +A +AV +F+I +
Sbjct: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALR-DGRWTGLVGDLLAGRAHMAVTSFSINS 536
Query: 505 EREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLA 564
R +V+DF+ PF + + I+ R P +W +L V L L
Sbjct: 537 ARSQVVDFTSPFFSTSLGIMVRAR--------DTASPIGAFMWPLHWSTWLGVFAALHLT 588
Query: 565 AR-LSPYEWYNPHPCL-RARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSG 622
A L+ YEW +P+ R R Y+ +L + + F + S P+ + R +
Sbjct: 589 ALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAI-LFRRTVSSKTPKCPTGRLLMN 647
Query: 623 VWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLA---DQTNIEYGTIHAGSTMTFFQ 679
+W F L+++SSYTANLAA + + + D +GT+ S + +
Sbjct: 648 LWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIK 707
Query: 680 NSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLN---SRYAFLLESTMNEYHRRL--NC 734
S + M + +T G+A + + AF+++ ++ +Y + +C
Sbjct: 708 KSFPDMHAHMRRHS--------APTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADC 759
Query: 735 NLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDH 794
L +G +GYGIG+P SP ++ I + + + +++L KW++ C K
Sbjct: 760 KLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFA 819
Query: 795 RAKGLGME--NIGGIFIVLICGLIIAVFVAVME---FIWSTRRSAESEEVSVCQEMLQEL 849
+ L M + G+F++L GL A+ ++ E F + R + + Q++
Sbjct: 820 VTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSRLQYWLHTSQKI 879
Query: 850 RHAVSCRKTSRSRR---RRRPGGPS---------------------RALLSLRAVREMRL 885
A++ S+ P GP RA+ R VR + L
Sbjct: 880 HRALNTEPPEGSKEETAEAEPSGPEVEQQQQQQDQPTAPEGWKRARRAVDKERRVRFL-L 938
Query: 886 SNGKLYSAGAGGDAGSA-HGGPQRLLDDPGPPSGARPAAPTPC------THVRVCQE--- 935
+ + A +A +A GP L PP+ AP P + V +E
Sbjct: 939 EPAVVVAPEADAEAEAAPREGPVWLCSYGRPPAARPTGAPQPGELQELERRIEVARERLR 998
Query: 936 ---CRRIQALRASGAGA--PPRGL----GVPAEATSPPRPRPG 969
RR Q L G A PR L PAEA P RPG
Sbjct: 999 QALVRRGQLLAQLGDSARHRPRRLLQARAAPAEA-PPHSGRPG 1040
>gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3
precursor [Homo sapiens]
Length = 433
Score = 86.3 bits (212), Expect = 1e-16
Identities = 96/404 (23%), Positives = 164/404 (40%), Gaps = 46/404 (11%)
Query: 41 RLALALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSP 100
RLA+ L N E P VD ++ + + T+ C +GV ++ G
Sbjct: 45 RLAIFLHNTSPNAS-EAPFNLVPHVD--NIETANSFAVTNAFCSQYSRGVFAIFGLYDK- 100
Query: 101 ASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPS 160
S T++ C I I Q++ + L PS L+ +L + +
Sbjct: 101 RSVHTLTSFCSALHISLITPSFPTEGESQFV----LQLRPSLRGALLS---LLDHYEW-- 151
Query: 161 ASLICAKAECLLRLEELVRGFLISKETL----------SVRMLDDSRDPT--PLLKEIRD 208
C + L + RG+ I + + S +++ D + LL+E+
Sbjct: 152 --------NCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDR 203
Query: 209 DKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFS 268
+ +ID IL + +G Y YI+ + F + L+ + +N+ GF
Sbjct: 204 RQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQ 263
Query: 269 MFNTSHPFYPEFV-RSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEI 327
+ + + P + + R + RE + T P ++AL +D V V+ R L R Q+I
Sbjct: 264 LVDFNTPMVIKLMDRWKKLDQREYPGSET--PPKYTSALTYDGVLVMAETFRSLRR-QKI 320
Query: 328 GVK------PLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKS 381
+ A W G + L+ V GLTG V+F+ G+R NYT+ + E
Sbjct: 321 DISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELK 380
Query: 382 RQGHREIGVW--YSNRTLAMNATTLDINLSQTLANKTLVVTTIL 423
G R++G W L + TL N + + N+T+VVTTI+
Sbjct: 381 STGPRKVGYWNDMDKLVLIQDVPTLG-NDTAAIENRTVVVTTIM 423
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,347,821
Number of Sequences: 37866
Number of extensions: 1862020
Number of successful extensions: 8950
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 156
Number of HSP's that attempted gapping in prelim test: 8403
Number of HSP's gapped (non-prelim): 511
length of query: 980
length of database: 18,247,518
effective HSP length: 112
effective length of query: 868
effective length of database: 14,006,526
effective search space: 12157664568
effective search space used: 12157664568
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.