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Search of human proteins with 29029595
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
(956 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29029595 glutamate receptor KA1 precursor [Homo sapiens] 1925 0.0
gi|29029597 glutamate receptor KA2 precursor [Homo sapiens] 1311 0.0
gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ... 705 0.0
gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2 ... 691 0.0
gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor ... 680 0.0
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ... 669 0.0
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p... 664 0.0
gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [H... 520 e-147
gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [H... 520 e-147
gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2 p... 514 e-145
gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1 p... 513 e-145
gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2 pr... 510 e-144
gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [H... 509 e-144
gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1 pre... 509 e-144
gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2 p... 496 e-140
gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1 p... 494 e-139
gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens] 305 1e-82
gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [H... 297 4e-80
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 241 2e-63
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 238 3e-62
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 238 3e-62
gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor ... 179 1e-44
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ... 176 9e-44
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ... 176 9e-44
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr... 176 9e-44
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [... 176 9e-44
gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor ... 174 4e-43
gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate... 150 5e-36
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat... 147 6e-35
gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3 p... 76 1e-13
>gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
Length = 956
Score = 1925 bits (4986), Expect = 0.0
Identities = 956/956 (100%), Positives = 956/956 (100%)
Query: 1 MPRVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLG 60
MPRVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLG
Sbjct: 1 MPRVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLG 60
Query: 61 KAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFK 120
KAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFK
Sbjct: 61 KAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFK 120
Query: 121 VAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLR 180
VAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLR
Sbjct: 121 VAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLR 180
Query: 181 QFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAY 240
QFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAY
Sbjct: 181 QFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAY 240
Query: 241 YTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTG 300
YTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTG
Sbjct: 241 YTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTG 300
Query: 301 PALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLT 360
PALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLT
Sbjct: 301 PALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLT 360
Query: 361 GHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVV 420
GHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVV
Sbjct: 361 GHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVV 420
Query: 421 TTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANG 480
TTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANG
Sbjct: 421 TTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANG 480
Query: 481 TWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFL 540
TWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFL
Sbjct: 481 TWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFL 540
Query: 541 DPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFP 600
DPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFP
Sbjct: 541 DPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFP 600
Query: 601 VGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLA 660
VGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLA
Sbjct: 601 VGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLA 660
Query: 661 DQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAF 720
DQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAF
Sbjct: 661 DQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAF 720
Query: 721 LLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILK 780
LLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILK
Sbjct: 721 LLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILK 780
Query: 781 RKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVS 840
RKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVS
Sbjct: 781 RKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVS 840
Query: 841 VCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPDQ 900
VCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPDQ
Sbjct: 841 VCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPDQ 900
Query: 901 LAQRLAQEAALVARGCTHIRVCPECRRFQGLRARPSPARSEESLEWEKTTNSSEPE 956
LAQRLAQEAALVARGCTHIRVCPECRRFQGLRARPSPARSEESLEWEKTTNSSEPE
Sbjct: 901 LAQRLAQEAALVARGCTHIRVCPECRRFQGLRARPSPARSEESLEWEKTTNSSEPE 956
>gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
Length = 980
Score = 1311 bits (3393), Expect = 0.0
Identities = 662/947 (69%), Positives = 766/947 (80%), Gaps = 24/947 (2%)
Query: 6 APLVLLPAWLVMVACSPH-----SLRIAAILDDPMECSRGERLSITLAKNRINRAPERLG 60
A L+LL L++ SP SLR+AAILDD C RGERL++ LA+ +IN E
Sbjct: 3 AELLLL---LIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPA 59
Query: 61 KAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFK 120
KA+VEVDIFEL RDS+YET +TMCQILPKGVV+VLGPSSSPAS+S +S+ICGEKE+PH K
Sbjct: 60 KARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIK 119
Query: 121 VAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLR 180
V PEE + Q+ RF +++L+PSN D+S+AV+ IL FN +A LICAKAECLL LE+L+R
Sbjct: 120 VGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVR 179
Query: 181 QFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAY 240
FLISK+TLSVRMLDD+RDPTPLLKEIRDDK +TIII ANAS+SH IL KA+ELGM SA+
Sbjct: 180 GFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAF 239
Query: 241 YTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTG 300
Y YI T ++F + +D +V+D NILGFS+FN SH F+ EF +SLN SW+ENC+ + G
Sbjct: 240 YKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLG 299
Query: 301 PALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLT 360
PALS+AL+FDAV+ VV+AV+ELNRSQEIGVKPL+C SA IW HGTSLMNYLRMVE +GLT
Sbjct: 300 PALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLT 359
Query: 361 GHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVV 420
G +EFNSKGQR+NY L+IL+ +R G R+IG W+ L+M++ N+S TL N TLVV
Sbjct: 360 GRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVV 419
Query: 421 TTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANG 480
TTILENPY+M + N Q + GN+R+EGFCVDML+ELAE+LRF Y++RLV DG+YG PE NG
Sbjct: 420 TTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNG 479
Query: 481 TWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFL 540
+WTGMVGELI RKADLAVA TITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFL
Sbjct: 480 SWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFL 539
Query: 541 DPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFP 600
DPFSP VWLFMLLAYLAVSCVLFL ARL+PYEWY+PHPC + R ++L NQY+LGNSLWFP
Sbjct: 540 DPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFP 599
Query: 601 VGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLA 660
VGGFMQQGS I PRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRM+VP+ES DDLA
Sbjct: 600 VGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLA 659
Query: 661 DQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAF 720
DQT IEYGTIH GS+MTFFQNSRYQTYQRMWNYM SKQPSVFVKSTEEGIARVLNS YAF
Sbjct: 660 DQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAF 719
Query: 721 LLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILK 780
LLESTMNEY+R+ NCNLTQIGGLLDTKGYGIGMP+GS FRDE LAILQLQENNRLEILK
Sbjct: 720 LLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILK 779
Query: 781 RKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHS-EATEV 839
RKWWEGG+CPKEEDHRAKGLGMENIGGIF+VLICGLI+A+F+A++EF+W+ R S E+ EV
Sbjct: 780 RKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEV 839
Query: 840 SVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPD 899
SVCQEM+ ELR + C+ + RRRR P R + R LSNGKL AG
Sbjct: 840 SVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALL--SLRAVREMRLSNGKLYSAGAGG 897
Query: 900 QLA------QRLAQEAA-------LVARGCTHIRVCPECRRFQGLRA 933
QRL + CTH+RVC ECRR Q LRA
Sbjct: 898 DAGSAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRA 944
>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
precursor [Homo sapiens]
Length = 908
Score = 705 bits (1819), Expect = 0.0
Identities = 395/907 (43%), Positives = 551/907 (60%), Gaps = 32/907 (3%)
Query: 3 RVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRG-ERLSITLAKNRINRAPERLGK 61
R + L+L W+ + H LR I + G E L+ A N INR L
Sbjct: 14 RRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPN 73
Query: 62 AKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKV 121
+ D ++ +E ++ C L GV A+ GPS S +S++ + +IC VPH +
Sbjct: 74 TTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHS-SSANAVQSICNALGVPHIQT 132
Query: 122 APEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQ 181
+ V F ++L+P + +S A+ ++ FF T ++ + L+ L++L++
Sbjct: 133 RWKHQVSDNKDSFY-VSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKA 191
Query: 182 FLISKDTLSVRMLD-DTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAY 240
L +R L DT+D PLLKE++ K +I + M+ IL +A +GM++ Y
Sbjct: 192 PSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEY 251
Query: 241 YTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQ-ENCDHVPFT 299
Y YIFT L+ ++ VN+ GF I N + S+ + W E P
Sbjct: 252 YHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQ----VSSIIEKWSMERLQAPPKP 307
Query: 300 GPAL-------SSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLR 352
L +AL++DAV+ V AVQ+ ++ V L C + W+ GT M+ ++
Sbjct: 308 DSGLLDGFMTTDAALMYDAVHVVSVAVQQF---PQMTVSSLQCNRHKPWRFGTRFMSLIK 364
Query: 353 MVELEGLTGHIEFN-SKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYA--SNI 409
EGLTG I FN + G R+++ L ++ G +IG W A GL+M +NI
Sbjct: 365 EAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANI 424
Query: 410 SDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVG 469
+D+L N +L+VTTILE PY++ K + + + GNDR+EG+C+D+L+EL+ IL F Y+IRLV
Sbjct: 425 TDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVE 484
Query: 470 DGVYGVPE-ANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRV 528
DG YG + ANG W GMV ELI KADLAVA L IT REKVIDFSKPFMTLGISILYR
Sbjct: 485 DGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRK 544
Query: 529 HMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLV 588
G PG FSFL+P SP +W+++LLAYL VSCVLF++AR +PYEWY+PHPC +++
Sbjct: 545 PNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDS-DVVE 603
Query: 589 NQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQR 648
N ++L NS WF VG MQQGS + P+ALSTR V G+WW FTLIIISSYTANLAAFLTV+R
Sbjct: 604 NNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVER 663
Query: 649 MDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEE 708
M+ PI+S DDLA QT IEYG + G++MTFF+ S+ TY +MW +M S++ SV VKS EE
Sbjct: 664 MESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEE 723
Query: 709 GIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAIL 768
GI RVL S+YAFL+EST E+ QRNCNLTQIGGL+D+KGYG+G P+GS +RD+ +AIL
Sbjct: 724 GIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAIL 783
Query: 769 QLQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFL 828
QLQE +L ++K KWW G CP+EE A LG++NIGGIF+VL GL++++F+A+ EFL
Sbjct: 784 QLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFL 843
Query: 829 W-TLRHSEATEVSVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATL 887
+ + ++++ + S C MV ELR + CQ RR P P I + T
Sbjct: 844 YKSKKNAQLEKRSFCSAMVEELRMSLKCQ-------RRLKHKPQAPVIVKTEEVINMHTF 896
Query: 888 SNGKLCG 894
++ +L G
Sbjct: 897 NDRRLPG 903
>gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2
precursor [Homo sapiens]
Length = 869
Score = 691 bits (1783), Expect = 0.0
Identities = 379/850 (44%), Positives = 526/850 (61%), Gaps = 24/850 (2%)
Query: 3 RVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRG-ERLSITLAKNRINRAPERLGK 61
R + L+L W+ + H LR I + G E L+ A N INR L
Sbjct: 14 RRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPN 73
Query: 62 AKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKV 121
+ D ++ +E ++ C L GV A+ GPS S +S++ + +IC VPH +
Sbjct: 74 TTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHS-SSANAVQSICNALGVPHIQT 132
Query: 122 APEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQ 181
+ V F ++L+P + +S A+ ++ FF T ++ + L+ L++L++
Sbjct: 133 RWKHQVSDNKDSFY-VSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKA 191
Query: 182 FLISKDTLSVRMLD-DTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAY 240
L +R L DT+D PLLKE++ K +I + M+ IL +A +GM++ Y
Sbjct: 192 PSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEY 251
Query: 241 YTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQ-ENCDHVPFT 299
Y YIFT L+ ++ VN+ GF I N + S+ + W E P
Sbjct: 252 YHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQ----VSSIIEKWSMERLQAPPKP 307
Query: 300 GPAL-------SSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLR 352
L +AL++DAV+ V AVQ+ ++ V L C + W+ GT M+ ++
Sbjct: 308 DSGLLDGFMTTDAALMYDAVHVVSVAVQQF---PQMTVSSLQCNRHKPWRFGTRFMSLIK 364
Query: 353 MVELEGLTGHIEFN-SKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYA--SNI 409
EGLTG I FN + G R+++ L ++ G +IG W A GL+M +NI
Sbjct: 365 EAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANI 424
Query: 410 SDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVG 469
+D+L N +L+VTTILE PY++ K + + + GNDR+EG+C+D+L+EL+ IL F Y+IRLV
Sbjct: 425 TDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVE 484
Query: 470 DGVYGVPE-ANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRV 528
DG YG + ANG W GMV ELI KADLAVA L IT REKVIDFSKPFMTLGISILYR
Sbjct: 485 DGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRK 544
Query: 529 HMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLV 588
G PG FSFL+P SP +W+++LLAYL VSCVLF++AR +PYEWY+PHPC +++
Sbjct: 545 PNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDS-DVVE 603
Query: 589 NQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQR 648
N ++L NS WF VG MQQGS + P+ALSTR V G+WW FTLIIISSYTANLAAFLTV+R
Sbjct: 604 NNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVER 663
Query: 649 MDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEE 708
M+ PI+S DDLA QT IEYG + G++MTFF+ S+ TY +MW +M S++ SV VKS EE
Sbjct: 664 MESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEE 723
Query: 709 GIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAIL 768
GI RVL S+YAFL+EST E+ QRNCNLTQIGGL+D+KGYG+G P+GS +RD+ +AIL
Sbjct: 724 GIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAIL 783
Query: 769 QLQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFL 828
QLQE +L ++K KWW G CP+EE A LG++NIGGIF+VL GL++++F+A+ EFL
Sbjct: 784 QLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFL 843
Query: 829 WTLRHSEATE 838
+ + + E
Sbjct: 844 YKSKKNAQLE 853
>gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
[Homo sapiens]
Length = 919
Score = 680 bits (1754), Expect = 0.0
Identities = 377/887 (42%), Positives = 537/887 (60%), Gaps = 36/887 (4%)
Query: 6 APLVLLPAWLVMVACSPHSLRIAAIL---DDP-MECSRGERLSITLAKNRINRAPERLGK 61
A L++ W+ PH +RI I D P + E + + N INR L
Sbjct: 17 AGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPN 76
Query: 62 AKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKV 121
+ DI + +E + C L GVVA+ GPS ++++ S IC EVPH ++
Sbjct: 77 TTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQS-ICNALEVPHIQL 135
Query: 122 APEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQ 181
+ F +NL+P +S A+ ++ + +A ++ + L+ L++L+
Sbjct: 136 RWKHHPLDNKDTFY-VNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMA 194
Query: 182 FLISKDTLSVRMLD-DTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAY 240
L +R L D+ D PLLKE++ + II + +M+ IL +A +GM++ Y
Sbjct: 195 PSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEY 254
Query: 241 YTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHA--------FFQEFAQSLNQSWQEN 292
Y +IFT L+ ++ VN+ GF I N + + E Q+ +S
Sbjct: 255 YHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGL 314
Query: 293 CDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLR 352
D V T +ALL+DAV+ V Q R+ ++ V L C + W+ G MN+++
Sbjct: 315 LDGVMMT----DAALLYDAVHIVSVCYQ---RAPQMTVNSLQCHRHKAWRFGGRFMNFIK 367
Query: 353 MVELEGLTGHIEFN-SKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYAS--NI 409
+ EGLTG I FN + G R+++ L I+ +G ++G W A+GL++ N+
Sbjct: 368 EAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNV 427
Query: 410 SDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVG 469
+D+L N +L+VTT+LE P++M + + + + GNDR+EG+C+D+LKELA IL F+Y+IRLV
Sbjct: 428 TDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVE 487
Query: 470 DGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVH 529
DG YG + G W GMV ELI KADLAVA LTIT REK IDFSKPFMTLG+SILYR
Sbjct: 488 DGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKP 547
Query: 530 MGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVN 589
G P FSFL+P SP +W+++LLAYL VSCVLF++AR +PYEWY HPC G ++ N
Sbjct: 548 NGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG-SEVVEN 606
Query: 590 QYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRM 649
++L NS WF +G MQQGS + P+ALSTR + G+WW FTLIIISSYTANLAAFLTV+RM
Sbjct: 607 NFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERM 666
Query: 650 DVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEG 709
+ PI+S DDLA QT IEYG + G++MTFF+ S+ T+++MW +M SK PS VK+ EEG
Sbjct: 667 ESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSK-PSALVKNNEEG 725
Query: 710 IARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQ 769
I R L ++YA L+EST EY QRNCNLTQIGGL+D+KGYGIG P+GS +RD+ +AILQ
Sbjct: 726 IQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQ 785
Query: 770 LQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLW 829
LQE ++L I+K KWW G CP+EE+ A LG++ IGGIF+VL GL++++ +A+ EF++
Sbjct: 786 LQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVY 845
Query: 830 TLRH-SEATEVSVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPI 875
LR +E + S C + E+R + CQ R P+PP+
Sbjct: 846 KLRKTAEREQRSFCSTVADEIRFSLTCQ--------RRVKHKPQPPM 884
>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
precursor [Homo sapiens]
Length = 905
Score = 669 bits (1727), Expect = 0.0
Identities = 370/852 (43%), Positives = 519/852 (60%), Gaps = 23/852 (2%)
Query: 16 VMVACSPHSLRIAAILDD-PMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFELLRD 74
++ +P LRI I + E E L+ A INR + + DI +
Sbjct: 28 ILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLF 87
Query: 75 SEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVA---PEEFVKFQF 131
+E + C L GV A+ GPS S +S S + +IC EVPH + P K F
Sbjct: 88 DSFEASRRACDQLALGVAALFGPSHS-SSVSAVQSICNALEVPHIQTRWKHPSVDNKDLF 146
Query: 132 QRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSV 191
+NL+P IS A+ ++ ++N T ++ + L+ L++L++ + +
Sbjct: 147 Y----INLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKI 202
Query: 192 RMLDD-TRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEF 250
R L +D PLLKE++ K +I + + IL + +GM++ YY Y FT L+
Sbjct: 203 RQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDL 262
Query: 251 SLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTG-----PALSS 305
++ VN+ GF + N + + + + P TG +
Sbjct: 263 FALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME-RLQAPPRPETGLLDGMMTTEA 321
Query: 306 ALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEF 365
AL++DAVY V A +R+ ++ V L C + W+ G MN ++ +GLTGHI F
Sbjct: 322 ALMYDAVYMVAIAS---HRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITF 378
Query: 366 N-SKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSM-DSHL-YASNISDTLFNTTLVVTT 422
N + G R ++ L I+ G +IG W+ GL+M DS+ +SNI+D+L N TL+VTT
Sbjct: 379 NKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTT 438
Query: 423 ILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTW 482
ILE PY+M + + + + GNDR+EG+C+D+LKEL+ IL F Y ++LV DG YG G W
Sbjct: 439 ILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEW 498
Query: 483 TGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDP 542
GMV ELI +ADLAVA LTIT REKVIDFSKPFMTLGISILYR G PG FSFL+P
Sbjct: 499 NGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNP 558
Query: 543 FSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVG 602
SP +W+++LLA L VSCVLF++AR TPYEWY+PHPC +++ N ++L NS WF VG
Sbjct: 559 LSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDS-DVVENNFTLLNSFWFGVG 617
Query: 603 GFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQ 662
MQQGS + P+ALSTR V G+WW FTLIIISSYTANLAAFLTV+RM+ PI+S DDLA Q
Sbjct: 618 ALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ 677
Query: 663 TAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLL 722
T IEYG + GS+MTFF+ S+ TY++MW +M S+Q + V++++EGI RVL ++YA L+
Sbjct: 678 TKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLM 737
Query: 723 ESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRK 782
EST EY QRNCNLTQIGGL+D+KGYG+G P+GS +RD+ +AILQLQE +L ++K K
Sbjct: 738 ESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEK 797
Query: 783 WWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVSVC 842
WW G CP+E++ A LG+ENIGGIF+VL GL++++F+A+ EF++ R + E +
Sbjct: 798 WWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQCLS 857
Query: 843 QEMVTELRSIIL 854
+ E I L
Sbjct: 858 FNAIMEELGISL 869
>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
precursor [Homo sapiens]
Length = 918
Score = 664 bits (1712), Expect = 0.0
Identities = 368/855 (43%), Positives = 518/855 (60%), Gaps = 38/855 (4%)
Query: 16 VMVACSPHSLRIAAILDD-PMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFELLRD 74
++ +P LRI I + E E L+ A INR + + DI +
Sbjct: 28 ILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLF 87
Query: 75 SEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVA---PEEFVKFQF 131
+E + C L GV A+ GPS S +S S + +IC EVPH + P K F
Sbjct: 88 DSFEASRRACDQLALGVAALFGPSHS-SSVSAVQSICNALEVPHIQTRWKHPSVDNKDLF 146
Query: 132 QRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSV 191
+NL+P IS A+ ++ ++N T ++ + L+ L++L++ + +
Sbjct: 147 Y----INLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKI 202
Query: 192 RMLDD-TRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEF 250
R L +D PLLKE++ K +I + + IL + +GM++ YY Y FT L+
Sbjct: 203 RQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDL 262
Query: 251 SLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTG-----PALSS 305
++ VN+ GF + N + + + + P TG +
Sbjct: 263 FALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME-RLQAPPRPETGLLDGMMTTEA 321
Query: 306 ALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEF 365
AL++DAVY V A +R+ ++ V L C + W+ G MN ++ +GLTGHI F
Sbjct: 322 ALMYDAVYMVAIAS---HRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITF 378
Query: 366 N-SKGQRSNYALKILQFTRNG---------------FRQIGQWHVAEGLSM-DSHL-YAS 407
N + G R ++ L I+ G +++IG W+ GL+M DS+ +S
Sbjct: 379 NKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSS 438
Query: 408 NISDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRL 467
NI+D+L N TL+VTTILE PY+M + + + + GNDR+EG+C+D+LKEL+ IL F Y ++L
Sbjct: 439 NITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKL 498
Query: 468 VGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYR 527
V DG YG G W GMV ELI +ADLAVA LTIT REKVIDFSKPFMTLGISILYR
Sbjct: 499 VPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYR 558
Query: 528 VHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLL 587
G PG FSFL+P SP +W+++LLA L VSCVLF++AR TPYEWY+PHPC +++
Sbjct: 559 KPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDS-DVV 617
Query: 588 VNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQ 647
N ++L NS WF VG MQQGS + P+ALSTR V G+WW FTLIIISSYTANLAAFLTV+
Sbjct: 618 ENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVE 677
Query: 648 RMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTE 707
RM+ PI+S DDLA QT IEYG + GS+MTFF+ S+ TY++MW +M S+Q + V++++
Sbjct: 678 RMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSD 737
Query: 708 EGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAI 767
EGI RVL ++YA L+EST EY QRNCNLTQIGGL+D+KGYG+G P+GS +RD+ +AI
Sbjct: 738 EGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAI 797
Query: 768 LQLQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEF 827
LQLQE +L ++K KWW G CP+E++ A LG+ENIGGIF+VL GL++++F+A+ EF
Sbjct: 798 LQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEF 857
Query: 828 LWTLRHSEATEVSVC 842
++ R + E + C
Sbjct: 858 IYKSRKNNDIEQAFC 872
>gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [Homo
sapiens]
Length = 906
Score = 520 bits (1340), Expect = e-147
Identities = 323/878 (36%), Positives = 482/878 (54%), Gaps = 57/878 (6%)
Query: 16 VMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFELLRDS 75
V+ A P++++I + P + S+ E + A +++ P+ L ++DI +
Sbjct: 16 VVGANFPNNIQIGGLF--PNQQSQ-EHAAFRFALSQLTEPPKLLP----QIDIVNI--SD 66
Query: 76 EYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEV----PHFKV-APEEFVKFQ 130
+E C KGV A+ G + +++++ CG V P F V +FV
Sbjct: 67 SFEMTYRFCSQFSKGVYAIFG-FYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFV--- 122
Query: 131 FQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISK-DTL 189
L L P D A+ I++ + I L L+K+L
Sbjct: 123 ------LQLRPELQD---ALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVT 173
Query: 190 SVRMLDDTRDPTPLL-KEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNL 248
+V +L T + +L +++ K +++ + + IL + +L Y YI NL
Sbjct: 174 AVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANL 233
Query: 249 EFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALSSALL 308
F ++ + N+ GF + N + + Q S + V + P +SAL
Sbjct: 234 GFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALT 293
Query: 309 FDAVYAVVTAVQELNR-----SQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHI 363
+D V + A Q L R S+ A W G + L+ V EGLTG++
Sbjct: 294 YDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNV 353
Query: 364 EFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEG-LSMDSHLYASNISDTLFNTTLVVTT 422
+FN KG+R+NY L +++ +G R+IG W+ + + + A + ++ N T +VTT
Sbjct: 354 QFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTT 413
Query: 423 ILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANG-T 481
ILE+PY+MLK N + EGNDRYEG+CV++ E+A+ + ++Y++ +V DG YG + +
Sbjct: 414 ILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKA 473
Query: 482 WTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLD 541
W GMVGEL+ +AD+AVA LTIT RE+VIDFSKPFM+LGISI+ + KPG FSFLD
Sbjct: 474 WNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD 533
Query: 542 PFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLV---NQYSLGNSLW 598
P + +W+ ++ AY+ VS VLFLV+R +PYEW+S +GR N++ + NSLW
Sbjct: 534 PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEE-FEEGRDQTTSDQSNEFGIFNSLW 592
Query: 599 FPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDD 658
F +G FMQQG I+PR+LS R V GVWW FTLIIISSYTANLAAFLTV+RM PIES +D
Sbjct: 593 FSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED 652
Query: 659 LADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS-- 716
LA QT I YGT+ GS+ FF+ S+ +++MW YM S +PSVFV++TEEG+ RV S
Sbjct: 653 LAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKG 712
Query: 717 NYAFLLESTMNEYYRQRN-CNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNR 775
YA+LLESTMNEY QR C+ ++GG LD+KGYGI P GS R+ +LA+L+L E
Sbjct: 713 KYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGL 772
Query: 776 LEILKRKWW-EGGKCPK---EEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTL 831
L+ LK KWW + G+C + + L + N+ G+F +LI GL +A+ +A++EF +
Sbjct: 773 LDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKS 832
Query: 832 RHSEATEVSVCQEMVTELRSIILCQDSIHPRRRRAAVP 869
R C ++ Q SI+ R + +P
Sbjct: 833 RSESKRMKGFC----------LIPQQSINEAIRTSTLP 860
>gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [Homo
sapiens]
Length = 906
Score = 520 bits (1338), Expect = e-147
Identities = 323/878 (36%), Positives = 482/878 (54%), Gaps = 57/878 (6%)
Query: 16 VMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFELLRDS 75
V+ A P++++I + P + S+ E + A +++ P+ L ++DI +
Sbjct: 16 VVGANFPNNIQIGGLF--PNQQSQ-EHAAFRFALSQLTEPPKLLP----QIDIVNI--SD 66
Query: 76 EYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEV----PHFKV-APEEFVKFQ 130
+E C KGV A+ G + +++++ CG V P F V +FV
Sbjct: 67 SFEMTYRFCSQFSKGVYAIFG-FYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFV--- 122
Query: 131 FQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISK-DTL 189
L L P D A+ I++ + I L L+K+L
Sbjct: 123 ------LQLRPELQD---ALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVT 173
Query: 190 SVRMLDDTRDPTPLL-KEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNL 248
+V +L T + +L +++ K +++ + + IL + +L Y YI NL
Sbjct: 174 AVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANL 233
Query: 249 EFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALSSALL 308
F ++ + N+ GF + N + + Q S + V + P +SAL
Sbjct: 234 GFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALT 293
Query: 309 FDAVYAVVTAVQELNR-----SQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHI 363
+D V + A Q L R S+ A W G + L+ V EGLTG++
Sbjct: 294 YDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNV 353
Query: 364 EFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEG-LSMDSHLYASNISDTLFNTTLVVTT 422
+FN KG+R+NY L +++ +G R+IG W+ + + + A + ++ N T +VTT
Sbjct: 354 QFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTT 413
Query: 423 ILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANG-T 481
ILE+PY+MLK N + EGNDRYEG+CV++ E+A+ + ++Y++ +V DG YG + +
Sbjct: 414 ILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKA 473
Query: 482 WTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLD 541
W GMVGEL+ +AD+AVA LTIT RE+VIDFSKPFM+LGISI+ + KPG FSFLD
Sbjct: 474 WNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD 533
Query: 542 PFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLV---NQYSLGNSLW 598
P + +W+ ++ AY+ VS VLFLV+R +PYEW+S +GR N++ + NSLW
Sbjct: 534 PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEE-FEEGRDQTTSDQSNEFGIFNSLW 592
Query: 599 FPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDD 658
F +G FMQQG I+PR+LS R V GVWW FTLIIISSYTANLAAFLTV+RM PIES +D
Sbjct: 593 FSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED 652
Query: 659 LADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS-- 716
LA QT I YGT+ GS+ FF+ S+ +++MW YM S +PSVFV++TEEG+ RV S
Sbjct: 653 LAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKG 712
Query: 717 NYAFLLESTMNEYYRQRN-CNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNR 775
YA+LLESTMNEY QR C+ ++GG LD+KGYGI P GS R +LA+L+L E
Sbjct: 713 KYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGV 772
Query: 776 LEILKRKWW-EGGKCPKEED---HRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTL 831
L+ LK KWW + G+C ++ + L + N+ G+F +LI GL +A+ +A++EF +
Sbjct: 773 LDKLKSKWWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKS 832
Query: 832 RHSEATEVSVCQEMVTELRSIILCQDSIHPRRRRAAVP 869
R C ++ Q SI+ R + +P
Sbjct: 833 RSESKRMKGFC----------LIPQQSINEAIRTSTLP 860
>gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2
precursor [Homo sapiens]
Length = 894
Score = 514 bits (1324), Expect = e-145
Identities = 283/661 (42%), Positives = 405/661 (61%), Gaps = 19/661 (2%)
Query: 190 SVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLE 249
SV + D ++ +++E+ + +I +TIL + LG S Y Y+ NL
Sbjct: 192 SVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLG 251
Query: 250 FSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALSSALLF 309
F+ ++ ++ NI GF I N + Q+F Q + + +SAL
Sbjct: 252 FTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTH 311
Query: 310 DAVYAVVTAVQELNRSQEIGVKPLSCGS-----AQIWQHGTSLMNYLRMVELEGLTGHIE 364
DA+ + A + L R + + S G A W G + L+MV+++G+TG+I+
Sbjct: 312 DAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQ 371
Query: 365 FNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTIL 424
F++ G+R+NY + + + +G R+ G W+ E S SN S + N T+VVTTIL
Sbjct: 372 FDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASSENRTIVVTTIL 431
Query: 425 ENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGV--PEANGTW 482
E+PY+M K NH+++EGN+RYEG+CVD+ E+A+ +R YK+ +VGDG YG PE W
Sbjct: 432 ESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETK-IW 490
Query: 483 TGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDP 542
GMVGEL+ +AD+AVA LTIT RE+VIDFSKPFM+LGISI+ + KPG FSFLDP
Sbjct: 491 NGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDP 550
Query: 543 FSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLV----NQYSLGNSLW 598
+ +W+ ++ AY+ VS VLFLV+R +PYEW+ + R N++ + NSLW
Sbjct: 551 LAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLW 610
Query: 599 FPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDD 658
F +G FMQQG I+PR+LS R V GVWW FTLIIISSYTANLAAFLTV+RM PIES +D
Sbjct: 611 FSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED 670
Query: 659 LADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS-- 716
LA QT I YGT+ GS+ FF+ S+ Y++MW+YM S +PSVF K+T +G+ARV S
Sbjct: 671 LAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKG 730
Query: 717 NYAFLLESTMNEYYRQRN-CNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNR 775
+AFLLESTMNEY QR C+ ++GG LD+KGYG+ P GS + +LA+L+L E
Sbjct: 731 KFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLNEQGL 790
Query: 776 LEILKRKWW-EGGKCPK---EEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTL 831
L+ LK KWW + G+C + + L + N+ G+F +L+ GL +A+ +A++EF +
Sbjct: 791 LDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKS 850
Query: 832 R 832
R
Sbjct: 851 R 851
>gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
precursor [Homo sapiens]
Length = 894
Score = 513 bits (1322), Expect = e-145
Identities = 283/661 (42%), Positives = 405/661 (61%), Gaps = 19/661 (2%)
Query: 190 SVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLE 249
SV + D ++ +++E+ + +I +TIL + LG S Y Y+ NL
Sbjct: 192 SVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLG 251
Query: 250 FSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALSSALLF 309
F+ ++ ++ NI GF I N + Q+F Q + + +SAL
Sbjct: 252 FTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTH 311
Query: 310 DAVYAVVTAVQELNRSQEIGVKPLSCGS-----AQIWQHGTSLMNYLRMVELEGLTGHIE 364
DA+ + A + L R + + S G A W G + L+MV+++G+TG+I+
Sbjct: 312 DAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQ 371
Query: 365 FNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTIL 424
F++ G+R+NY + + + +G R+ G W+ E S SN S + N T+VVTTIL
Sbjct: 372 FDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASSENRTIVVTTIL 431
Query: 425 ENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGV--PEANGTW 482
E+PY+M K NH+++EGN+RYEG+CVD+ E+A+ +R YK+ +VGDG YG PE W
Sbjct: 432 ESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETK-IW 490
Query: 483 TGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDP 542
GMVGEL+ +AD+AVA LTIT RE+VIDFSKPFM+LGISI+ + KPG FSFLDP
Sbjct: 491 NGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDP 550
Query: 543 FSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLV----NQYSLGNSLW 598
+ +W+ ++ AY+ VS VLFLV+R +PYEW+ + R N++ + NSLW
Sbjct: 551 LAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLW 610
Query: 599 FPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDD 658
F +G FMQQG I+PR+LS R V GVWW FTLIIISSYTANLAAFLTV+RM PIES +D
Sbjct: 611 FSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED 670
Query: 659 LADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS-- 716
LA QT I YGT+ GS+ FF+ S+ Y++MW+YM S +PSVF K+T +G+ARV S
Sbjct: 671 LAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKG 730
Query: 717 NYAFLLESTMNEYYRQRN-CNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNR 775
+AFLLESTMNEY QR C+ ++GG LD+KGYG+ P GS +LA+L+L E
Sbjct: 731 KFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGI 790
Query: 776 LEILKRKWW-EGGKCPKEED---HRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTL 831
L+ LK KWW + G+C ++ + L + N+ G+F +L+ GL +A+ +A++EF +
Sbjct: 791 LDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKS 850
Query: 832 R 832
R
Sbjct: 851 R 851
>gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2
precursor [Homo sapiens]
Length = 883
Score = 510 bits (1314), Expect = e-144
Identities = 301/796 (37%), Positives = 449/796 (56%), Gaps = 41/796 (5%)
Query: 75 SEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVKFQFQRF 134
+ + C +GV A+ G S + I++ CG V F F
Sbjct: 69 NSFAVTNAFCSQFSRGVYAIFG-FYDKKSVNTITSFCGTLHV-----------SFITPSF 116
Query: 135 TTLNLHP----SNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLS 190
T HP D+ A+ ++ ++ + L L+ +L K ++
Sbjct: 117 PTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVT 176
Query: 191 V----RMLDDTRDPT--PLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYI 244
+ +D +D L +++ K +I+ + I+ + +G Y YI
Sbjct: 177 AINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYI 236
Query: 245 FTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALS 304
NL F+ + + N+ GF I + + +F + + ++ T +
Sbjct: 237 IANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYT 296
Query: 305 SALLFDAVYAVVTAVQELNRSQEIGVKPLS------CGSAQIWQHGTSLMNYLRMVELEG 358
SAL +DAV + A + L R Q I + A W G + L+ V++EG
Sbjct: 297 SALTYDAVQVMTEAFRNL-RKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEG 355
Query: 359 LTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMD-SHLYASNISDTLFNTT 417
L+G+I+F+ G+R NY + I++ NG R+IG W + + + + L + N + L N T
Sbjct: 356 LSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKT 415
Query: 418 LVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPE 477
+VVTTILE+PY+M+K NH+ +EGN+RYEG+CVD+ E+A+ F YK+ +VGDG YG +
Sbjct: 416 VVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD 475
Query: 478 ANGT-WTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGY 536
A+ W GMVGEL+ KAD+A+A LTIT RE+VIDFSKPFM+LGISI+ + KPG
Sbjct: 476 ADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 535
Query: 537 FSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPH--PCAQGRCNLLVNQYSLG 594
FSFLDP + +W+ ++ AY+ VS VLFLV+R +PYEW++ + + + N++ +
Sbjct: 536 FSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIF 595
Query: 595 NSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIE 654
NSLWF +G FM+QG I+PR+LS R V GVWW FTLIIISSYTANLAAFLTV+RM PIE
Sbjct: 596 NSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIE 655
Query: 655 SVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVL 714
S +DL+ QT I YGT+ GS+ FF+ S+ + +MW YM S +PSVFV++T EG+ARV
Sbjct: 656 SAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVR 715
Query: 715 NS--NYAFLLESTMNEYYRQRN-CNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQ 771
S YA+LLESTMNEY QR C+ ++GG LD+KGYGI P GS R+ +LA+L+L
Sbjct: 716 KSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLN 775
Query: 772 ENNRLEILKRKWW-EGGKCPK---EEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEF 827
E L+ LK KWW + G+C + + L + N+ G+F +L+ GL +A+ +A++EF
Sbjct: 776 EQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEF 835
Query: 828 LWTLRHSEATEVSVCQ 843
+ R +EA + V +
Sbjct: 836 CYKSR-AEAKRMKVAK 850
>gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [Homo
sapiens]
Length = 836
Score = 509 bits (1312), Expect = e-144
Identities = 301/796 (37%), Positives = 449/796 (56%), Gaps = 41/796 (5%)
Query: 75 SEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVKFQFQRF 134
+ + C +GV A+ G S + I++ CG V F F
Sbjct: 22 NSFAVTNAFCSQFSRGVYAIFG-FYDKKSVNTITSFCGTLHV-----------SFITPSF 69
Query: 135 TTLNLHP----SNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLS 190
T HP D+ A+ ++ ++ + L L+ +L K ++
Sbjct: 70 PTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVT 129
Query: 191 V----RMLDDTRDPT--PLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYI 244
+ +D +D L +++ K +I+ + I+ + +G Y YI
Sbjct: 130 AINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYI 189
Query: 245 FTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALS 304
NL F+ + + N+ GF I + + +F + + ++ T +
Sbjct: 190 IANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYT 249
Query: 305 SALLFDAVYAVVTAVQELNRSQEIGVKPLS------CGSAQIWQHGTSLMNYLRMVELEG 358
SAL +DAV + A + L R Q I + A W G + L+ V++EG
Sbjct: 250 SALTYDAVQVMTEAFRNL-RKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEG 308
Query: 359 LTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMD-SHLYASNISDTLFNTT 417
L+G+I+F+ G+R NY + I++ NG R+IG W + + + + L + N + L N T
Sbjct: 309 LSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKT 368
Query: 418 LVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPE 477
+VVTTILE+PY+M+K NH+ +EGN+RYEG+CVD+ E+A+ F YK+ +VGDG YG +
Sbjct: 369 VVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD 428
Query: 478 ANGT-WTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGY 536
A+ W GMVGEL+ KAD+A+A LTIT RE+VIDFSKPFM+LGISI+ + KPG
Sbjct: 429 ADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 488
Query: 537 FSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPH--PCAQGRCNLLVNQYSLG 594
FSFLDP + +W+ ++ AY+ VS VLFLV+R +PYEW++ + + + N++ +
Sbjct: 489 FSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIF 548
Query: 595 NSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIE 654
NSLWF +G FM+QG I+PR+LS R V GVWW FTLIIISSYTANLAAFLTV+RM PIE
Sbjct: 549 NSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIE 608
Query: 655 SVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVL 714
S +DL+ QT I YGT+ GS+ FF+ S+ + +MW YM S +PSVFV++T EG+ARV
Sbjct: 609 SAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVR 668
Query: 715 NS--NYAFLLESTMNEYYRQRN-CNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQ 771
S YA+LLESTMNEY QR C+ ++GG LD+KGYGI P GS R +LA+L+L
Sbjct: 669 KSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLS 728
Query: 772 ENNRLEILKRKWW-EGGKCPKEED---HRAKGLGMENIGGIFVVLICGLIVAIFMAMLEF 827
E L+ LK KWW + G+C ++ + L + N+ G+F +L+ GL +A+ +A++EF
Sbjct: 729 EQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEF 788
Query: 828 LWTLRHSEATEVSVCQ 843
+ R +EA + V +
Sbjct: 789 CYKSR-AEAKRMKVAK 803
>gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1
precursor [Homo sapiens]
Length = 883
Score = 509 bits (1312), Expect = e-144
Identities = 301/796 (37%), Positives = 449/796 (56%), Gaps = 41/796 (5%)
Query: 75 SEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVKFQFQRF 134
+ + C +GV A+ G S + I++ CG V F F
Sbjct: 69 NSFAVTNAFCSQFSRGVYAIFG-FYDKKSVNTITSFCGTLHV-----------SFITPSF 116
Query: 135 TTLNLHP----SNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLS 190
T HP D+ A+ ++ ++ + L L+ +L K ++
Sbjct: 117 PTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVT 176
Query: 191 V----RMLDDTRDPT--PLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYI 244
+ +D +D L +++ K +I+ + I+ + +G Y YI
Sbjct: 177 AINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYI 236
Query: 245 FTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALS 304
NL F+ + + N+ GF I + + +F + + ++ T +
Sbjct: 237 IANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYT 296
Query: 305 SALLFDAVYAVVTAVQELNRSQEIGVKPLS------CGSAQIWQHGTSLMNYLRMVELEG 358
SAL +DAV + A + L R Q I + A W G + L+ V++EG
Sbjct: 297 SALTYDAVQVMTEAFRNL-RKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEG 355
Query: 359 LTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMD-SHLYASNISDTLFNTT 417
L+G+I+F+ G+R NY + I++ NG R+IG W + + + + L + N + L N T
Sbjct: 356 LSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKT 415
Query: 418 LVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPE 477
+VVTTILE+PY+M+K NH+ +EGN+RYEG+CVD+ E+A+ F YK+ +VGDG YG +
Sbjct: 416 VVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD 475
Query: 478 ANGT-WTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGY 536
A+ W GMVGEL+ KAD+A+A LTIT RE+VIDFSKPFM+LGISI+ + KPG
Sbjct: 476 ADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 535
Query: 537 FSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPH--PCAQGRCNLLVNQYSLG 594
FSFLDP + +W+ ++ AY+ VS VLFLV+R +PYEW++ + + + N++ +
Sbjct: 536 FSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIF 595
Query: 595 NSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIE 654
NSLWF +G FM+QG I+PR+LS R V GVWW FTLIIISSYTANLAAFLTV+RM PIE
Sbjct: 596 NSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIE 655
Query: 655 SVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVL 714
S +DL+ QT I YGT+ GS+ FF+ S+ + +MW YM S +PSVFV++T EG+ARV
Sbjct: 656 SAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVR 715
Query: 715 NS--NYAFLLESTMNEYYRQRN-CNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQ 771
S YA+LLESTMNEY QR C+ ++GG LD+KGYGI P GS R +LA+L+L
Sbjct: 716 KSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLS 775
Query: 772 ENNRLEILKRKWW-EGGKCPKEED---HRAKGLGMENIGGIFVVLICGLIVAIFMAMLEF 827
E L+ LK KWW + G+C ++ + L + N+ G+F +L+ GL +A+ +A++EF
Sbjct: 776 EQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEF 835
Query: 828 LWTLRHSEATEVSVCQ 843
+ R +EA + V +
Sbjct: 836 CYKSR-AEAKRMKVAK 850
>gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2
precursor [Homo sapiens]
Length = 884
Score = 496 bits (1277), Expect = e-140
Identities = 276/666 (41%), Positives = 398/666 (59%), Gaps = 28/666 (4%)
Query: 203 LLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDR 262
LL+E+ + +I IL + +G Y YI NL F ++ +
Sbjct: 197 LLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGG 256
Query: 263 VNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTG----PALSSALLFDAVYAVVTA 318
N+ GF + + F L W++ D + G P +SAL +D V +
Sbjct: 257 ANVTGFQLVD----FNTPMVIKLMDRWKK-LDQREYPGSETPPKYTSALTYDGVLVMAET 311
Query: 319 VQELNRSQEIGVKPLS------CGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRS 372
+ L R Q+I + A W G + L+ V ++GLTG+++F+ G+R
Sbjct: 312 FRSLRR-QKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRV 370
Query: 373 NYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYA-SNISDTLFNTTLVVTTILENPYLML 431
NY + + + G R++G W+ + L + + N + + N T+VVTTI+E+PY+M
Sbjct: 371 NYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVTTIMESPYVMY 430
Query: 432 KGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGT-WTGMVGELI 490
K NH+ EGND+YEG+CVD+ E+A+ + YKI +V DG YG +A+ W GMVGEL+
Sbjct: 431 KKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELV 490
Query: 491 ARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLF 550
KA++A+A LTIT RE+VIDFSKPFM+LGISI+ + KPG FSFLDP + +W+
Sbjct: 491 YGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMC 550
Query: 551 MLLAYLAVSCVLFLVARLTPYEWYSPHP--CAQGRCNLLVNQYSLGNSLWFPVGGFMQQG 608
++ AY+ VS VLFLV+R +PYEW++ P +G + N++ + NSLWF +G FMQQG
Sbjct: 551 IVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQG 610
Query: 609 STIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYG 668
I+PR+LS R V GVWW FTLIIISSYTANLAAFLTV+RM PIES +DLA QT I YG
Sbjct: 611 CDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYG 670
Query: 669 TIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS--NYAFLLESTM 726
T+ GS+ FF+ S+ Y++MW YM S +PSVF ++T EG+ARV S +AFLLESTM
Sbjct: 671 TLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTM 730
Query: 727 NEYYRQRN-CNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWW- 784
NEY QR C+ ++GG LD+KGYG+ P GS + +LA+L+L E L+ LK KWW
Sbjct: 731 NEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWY 790
Query: 785 EGGKCPK---EEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVSV 841
+ G+C + + L + N+ G+F +L+ GL +A+ +A++EF + R +EA + V
Sbjct: 791 DKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR-AEAKRMKV 849
Query: 842 CQEMVT 847
+ T
Sbjct: 850 AKSAQT 855
>gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1
precursor [Homo sapiens]
Length = 902
Score = 494 bits (1273), Expect = e-139
Identities = 275/651 (42%), Positives = 393/651 (60%), Gaps = 27/651 (4%)
Query: 203 LLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDR 262
LL+E+ + +I IL + +G Y YI NL F ++ +
Sbjct: 197 LLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGG 256
Query: 263 VNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTG----PALSSALLFDAVYAVVTA 318
N+ GF + + F L W++ D + G P +SAL +D V +
Sbjct: 257 ANVTGFQLVD----FNTPMVIKLMDRWKK-LDQREYPGSETPPKYTSALTYDGVLVMAET 311
Query: 319 VQELNRSQEIGVKPLS------CGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRS 372
+ L R Q+I + A W G + L+ V ++GLTG+++F+ G+R
Sbjct: 312 FRSLRR-QKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRV 370
Query: 373 NYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYA-SNISDTLFNTTLVVTTILENPYLML 431
NY + + + G R++G W+ + L + + N + + N T+VVTTI+E+PY+M
Sbjct: 371 NYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVTTIMESPYVMY 430
Query: 432 KGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGT-WTGMVGELI 490
K NH+ EGND+YEG+CVD+ E+A+ + YKI +V DG YG +A+ W GMVGEL+
Sbjct: 431 KKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELV 490
Query: 491 ARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLF 550
KA++A+A LTIT RE+VIDFSKPFM+LGISI+ + KPG FSFLDP + +W+
Sbjct: 491 YGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMC 550
Query: 551 MLLAYLAVSCVLFLVARLTPYEWYSPHP--CAQGRCNLLVNQYSLGNSLWFPVGGFMQQG 608
++ AY+ VS VLFLV+R +PYEW++ P +G + N++ + NSLWF +G FMQQG
Sbjct: 551 IVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQG 610
Query: 609 STIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYG 668
I+PR+LS R V GVWW FTLIIISSYTANLAAFLTV+RM PIES +DLA QT I YG
Sbjct: 611 CDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYG 670
Query: 669 TIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS--NYAFLLESTM 726
T+ GS+ FF+ S+ Y++MW YM S +PSVF ++T EG+ARV S +AFLLESTM
Sbjct: 671 TLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTM 730
Query: 727 NEYYRQRN-CNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWW- 784
NEY QR C+ ++GG LD+KGYG+ P GS +LA+L+L E L+ LK KWW
Sbjct: 731 NEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLGTPVNLAVLKLSEAGVLDKLKNKWWY 790
Query: 785 EGGKC-PKEEDHRAK--GLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLR 832
+ G+C PK+ + K L + N+ G+F +L+ GL +A+ +A++EF + R
Sbjct: 791 DKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR 841
>gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]
Length = 1007
Score = 305 bits (782), Expect = 1e-82
Identities = 206/659 (31%), Positives = 337/659 (51%), Gaps = 50/659 (7%)
Query: 204 LKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRV 263
L RD I++ N + + + + + E +V+ +I N E + + LV R
Sbjct: 220 LNRYRDTLRRAILV-MNPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELV--RR 276
Query: 264 NILGFSIFNQSHAFFQEFAQSL----NQSWQENCDHV-PFT-GPALSSALLFDAVYAVVT 317
+I +I Q+ Q +Q ++ CD PF +S+ ++D V +
Sbjct: 277 SIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLAN 336
Query: 318 AV-QELNRSQEIGVKPLSC--GSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNY 374
A ++L + + LSC +++ WQ G S++ ++ + GLTG +EF G N
Sbjct: 337 AFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNV 396
Query: 375 ALKIL-----QFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTILENPYL 429
+IL + G R++G W+ GL+ L + + + L V T+LE P++
Sbjct: 397 HFEILGTNYGEELGRGVRKLGCWNPVTGLN--GSLTDKKLENNMRGVVLRVVTVLEEPFV 454
Query: 430 MLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGEL 489
M+ N + +Y+GF +D+L L+ L FNY+I + D YG P+ +GTW G+VGEL
Sbjct: 455 MVSEN--VLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGEL 512
Query: 490 IARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWL 549
+ ++AD+ ++ LTIT +RE V+DF+ +M + +L R + F+ L PF +W
Sbjct: 513 VFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR-RAEKTVDMFACLAPFDLSLWA 571
Query: 550 FMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGS 609
+ L V +++L+ W +P G + +L NS+WF G F+QQG
Sbjct: 572 CIAGTVLLVGLLVYLL------NWLNPPRLQMGS----MTSTTLYNSMWFVYGSFVQQGG 621
Query: 610 TIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGT 669
+ L+TR + G WW F LI+ISSYTANLAAFLT+ R++ I+S+ DL+ QT I YGT
Sbjct: 622 EVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTEIPYGT 681
Query: 670 IHGGSSM---------TFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAF 720
+ + F ++S Y RM N + +V ++ GI +V NYAF
Sbjct: 682 VLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVL--ESQAGIQKVKYGNYAF 739
Query: 721 LLESTMNEY--YRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEI 778
+ ++ + EY +C+ IG + +GYGI + GS +RD F IL+LQ+N ++I
Sbjct: 740 VWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDI 799
Query: 779 LKRKWW-EGGKCP--KEEDHRAKG--LGMENIGGIFVVLICGLIVAIFMAMLEFLWTLR 832
LK KWW + G+C D + KG L +++ G+F +L G++++ F+AMLE W R
Sbjct: 800 LKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETWWNKR 858
>gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [Homo
sapiens]
Length = 1009
Score = 297 bits (760), Expect = 4e-80
Identities = 257/929 (27%), Positives = 422/929 (45%), Gaps = 105/929 (11%)
Query: 11 LPAWLVMVACSPHSLR------IAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKV 64
L WL+ C S+R I AI ++ ++ +R+ LA + ++ + L K+
Sbjct: 4 LTLWLLPWICQCVSVRADSIIHIGAIFEE--NAAKDDRV-FQLAVSDLSLNDDILQSEKI 60
Query: 65 EVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPE 124
I + ++ ++ + C ++ +G++A++ S+ AS++ + ++ +PH V
Sbjct: 61 TYSIKVIEANNPFQAVQEACDLMTQGILALV-TSTGCASANALQSLTDAMHIPHLFVQRN 119
Query: 125 EFVKFQFQRFTTLNLHPSNTDISVAVAG------------ILNFFNCTTACLICAKAECL 172
+ T +L+PS + +A ++ + +
Sbjct: 120 PGGSPR----TACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDI 175
Query: 173 LNLEKLLRQFLISKDTLSVRMLDD----------TRDPTPLLKEIRDDKTATIIIHANAS 222
L+ L Q +S++ +D T T L RD I++ +
Sbjct: 176 RGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILL-LSPQ 234
Query: 223 MSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFA 282
+H+ + +A E + S ++F N E S D + L S + Q F
Sbjct: 235 GAHSFINEAVETNLASKDSHWVFVNEEIS--------DPEILDLVHSALGRMTVVRQIFP 286
Query: 283 QSL-NQSWQEN--------CDHVPFTGPA----LSSALLFDAVYAVVTAV-QELNRSQEI 328
+ NQ N CD P G +S+ L+D+V + A ++L +
Sbjct: 287 SAKDNQKCTRNNHRISSLLCD--PQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWH 344
Query: 329 GVKPLSC--GSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRN-- 384
+ L+C S + W G S+++ ++ + GLTG +EF +IL T +
Sbjct: 345 SMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSET 404
Query: 385 ---GFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTILENPYLMLKGNHQEMEGN 441
R++ W +GL+ L + L TL V T+LE P++M+ N +
Sbjct: 405 FGKDMRKLATWDSEKGLN--GSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENI--LGQP 460
Query: 442 DRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGL 501
RY+GF +D+L LA+ L F Y+I DG YG N +W GM+GELI+++ADLA++ +
Sbjct: 461 KRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAI 520
Query: 502 TITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCV 561
TIT ERE V+DFSK +M + IL + K FS PF VW + A V +
Sbjct: 521 TITPERESVVDFSKRYMDYSVGILIK-KPEEKISIFSLFAPFDFAVWACIAAAIPVVGVL 579
Query: 562 LFLVARLTPYEWYS---PHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALST 618
+F++ R+ S P P A +L +++W G F+QQG + +++
Sbjct: 580 IFVLNRIQAVRAQSAAQPRPSASA---------TLHSAIWIVYGAFVQQGGESSVNSMAM 630
Query: 619 RCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTF 678
R V G WW FTLI+ SSYTANLAAFLTV RMD PI + DL+ Q + YGT+ + +
Sbjct: 631 RIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEY 690
Query: 679 FQN------SRYQTYQRMWNYMYSKQPSV--FVKSTEEGIARVLNSNYAFLLESTMNEY- 729
F+ + T+ +W + SK V S EGI + NYAFL + + EY
Sbjct: 691 FRAKGTNPLEQDSTFAELWRTI-SKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYA 749
Query: 730 -YRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWW-EGG 787
+C++T IG + +KGYGI + GS +RD F IL+LQ+ L++LK+KWW G
Sbjct: 750 ALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMG 809
Query: 788 KCPKEEDHRA----KGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLR--HSEA--TEV 839
+C A K L + + G+F +L GL++A +A LE W H E +
Sbjct: 810 RCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPKEDK 869
Query: 840 SVCQEMVTELRSIILCQDSIHPRRRRAAV 868
V E V + ++ +D H + A++
Sbjct: 870 EVNLEQVHRRMNSLMDEDIAHKQISPASI 898
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 241 bits (615), Expect = 2e-63
Identities = 224/927 (24%), Positives = 395/927 (42%), Gaps = 125/927 (13%)
Query: 9 VLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDI 68
+L + AC P + I A+L R + + +N+A +R G K++++
Sbjct: 11 LLFSCSVARAACDPKIVNIGAVLST--------RKHEQMFREAVNQANKRHGSWKIQLNA 62
Query: 69 FELL-RDSEYETAETMCQILPKGVVAVLGPSSSPASS-----SIISNICGEKEVP----- 117
+ + + + A ++C+ L V + S P + + +S G +P
Sbjct: 63 TSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLT 122
Query: 118 -HFKVAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLE 176
+ ++ + F R H S+ + + ++ L+ + +
Sbjct: 123 TRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEM-----MRVYSWNHIILLVSDDHEGRAAQ 177
Query: 177 KLLRQFLISKDTLSVRMLD---DTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAE 233
K L L +++ + ++L T++ T LL E ++ + II+ A+ + T+ AA
Sbjct: 178 KRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAM 237
Query: 234 LGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENC 293
L M + Y ++ E S + D ILG + N +
Sbjct: 238 LNMTGSGYVWLVGEREISGNALRYAPD---GILGLQLINGKN------------------ 276
Query: 294 DHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSC-GSAQIWQHGTSLMNYLR 352
SA + DAV V AV EL + I P C G+ IW+ G L
Sbjct: 277 ----------ESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLM 326
Query: 353 MVEL-EGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLY-----A 406
+ +G+TG +EFN G R I+ Q+G ++ + D +
Sbjct: 327 SSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGET 386
Query: 407 SNISDTLFNTTLVVTTILENPYLMLK-------------------------GNHQEMEGN 441
+T L + TI + P++ +K G + G+
Sbjct: 387 EKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGS 446
Query: 442 DRYE------GFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGT-----WTGMVGELI 490
R+ GFC+D+L +LA + F Y++ LV DG +G E W GM+GEL+
Sbjct: 447 PRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELL 506
Query: 491 ARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLF 550
+ +AD+ VA LTI ER + I+FSKPF G++IL + + R SF+ PF +WL
Sbjct: 507 SGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRST-LDSFMQPFQSTLWLL 565
Query: 551 MLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQG-S 609
+ L+ V+ +L+L+ R +P+ + + + + +L +++WF G + G
Sbjct: 566 VGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEE-----DALTLSSAMWFSWGVLLNSGIG 620
Query: 610 TIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIE--- 666
APR+ S R + VW F +II++SYTANLAAFL + R + I ++D + +
Sbjct: 621 EGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFI 680
Query: 667 YGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVL-NSNYAFLLEST 725
Y T+ S +F+ Q + MY +S E I V N +AF+ +S
Sbjct: 681 YATVKQSSVDIYFRR------QVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSA 734
Query: 726 MNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWE 785
+ E+ + C+L G L G+GIGM S ++ L+IL+ EN +E L + W
Sbjct: 735 VLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVR 794
Query: 786 GGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVSVCQEM 845
+C + A L EN+ G+F+++ G++ IF+ +E + RH +A ++M
Sbjct: 795 YQECDSRSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYK-RHKDARR----KQM 848
Query: 846 VTELRSIILCQDSIHPRRRRAAVPPPR 872
++ + + ++ R+ A P P+
Sbjct: 849 QLAFAAVNVWRKNLQDRKSGRAEPDPK 875
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 238 bits (606), Expect = 3e-62
Identities = 219/891 (24%), Positives = 380/891 (42%), Gaps = 121/891 (13%)
Query: 9 VLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDI 68
+L + AC P + I A+L R + + +N+A +R G K++++
Sbjct: 11 LLFSCSVARAACDPKIVNIGAVLST--------RKHEQMFREAVNQANKRHGSWKIQLNA 62
Query: 69 FELL-RDSEYETAETMCQILPKGVVAVLGPSSSPASS-----SIISNICGEKEVP----- 117
+ + + + A ++C+ L V + S P + + +S G +P
Sbjct: 63 TSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLT 122
Query: 118 -HFKVAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLE 176
+ ++ + F R H S+ + + ++ L+ + +
Sbjct: 123 TRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEM-----MRVYSWNHIILLVSDDHEGRAAQ 177
Query: 177 KLLRQFLISKDTLSVRMLD---DTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAE 233
K L L +++ + ++L T++ T LL E ++ + II+ A+ + T+ AA
Sbjct: 178 KRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAM 237
Query: 234 LGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENC 293
L M + Y ++ E S + D ILG + N +
Sbjct: 238 LNMTGSGYVWLVGEREISGNALRYAPD---GILGLQLINGKN------------------ 276
Query: 294 DHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSC-GSAQIWQHGTSLMNYLR 352
SA + DAV V AV EL + I P C G+ IW+ G L
Sbjct: 277 ----------ESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLM 326
Query: 353 MVEL-EGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLY-----A 406
+ +G+TG +EFN G R I+ Q+G ++ + D +
Sbjct: 327 SSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGET 386
Query: 407 SNISDTLFNTTLVVTTILENPYLMLK-------------------------GNHQEMEGN 441
+T L + TI + P++ +K G + G+
Sbjct: 387 EKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGS 446
Query: 442 DRYE------GFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGT-----WTGMVGELI 490
R+ GFC+D+L +LA + F Y++ LV DG +G E W GM+GEL+
Sbjct: 447 PRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELL 506
Query: 491 ARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLF 550
+ +AD+ VA LTI ER + I+FSKPF G++IL + + R SF+ PF +WL
Sbjct: 507 SGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRST-LDSFMQPFQSTLWLL 565
Query: 551 MLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQG-S 609
+ L+ V+ +L+L+ R +P+ + + + + +L +++WF G + G
Sbjct: 566 VGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEE-----DALTLSSAMWFSWGVLLNSGIG 620
Query: 610 TIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIE--- 666
APR+ S R + VW F +II++SYTANLAAFL + R + I ++D + +
Sbjct: 621 EGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFI 680
Query: 667 YGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVL-NSNYAFLLEST 725
Y T+ S +F+ Q + MY +S E I V N +AF+ +S
Sbjct: 681 YATVKQSSVDIYFRR------QVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSA 734
Query: 726 MNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWE 785
+ E+ + C+L G L G+GIGM S ++ L+IL+ EN +E L + W
Sbjct: 735 VLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVR 794
Query: 786 GGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEA 836
+C + A L EN+ G+F+++ G++ IF+ +E + RH +A
Sbjct: 795 YQECDSRSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYK-RHKDA 843
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 238 bits (606), Expect = 3e-62
Identities = 219/891 (24%), Positives = 380/891 (42%), Gaps = 121/891 (13%)
Query: 9 VLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDI 68
+L + AC P + I A+L R + + +N+A +R G K++++
Sbjct: 11 LLFSCSVARAACDPKIVNIGAVLST--------RKHEQMFREAVNQANKRHGSWKIQLNA 62
Query: 69 FELL-RDSEYETAETMCQILPKGVVAVLGPSSSPASS-----SIISNICGEKEVP----- 117
+ + + + A ++C+ L V + S P + + +S G +P
Sbjct: 63 TSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLT 122
Query: 118 -HFKVAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLE 176
+ ++ + F R H S+ + + ++ L+ + +
Sbjct: 123 TRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEM-----MRVYSWNHIILLVSDDHEGRAAQ 177
Query: 177 KLLRQFLISKDTLSVRMLD---DTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAE 233
K L L +++ + ++L T++ T LL E ++ + II+ A+ + T+ AA
Sbjct: 178 KRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAM 237
Query: 234 LGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENC 293
L M + Y ++ E S + D ILG + N +
Sbjct: 238 LNMTGSGYVWLVGEREISGNALRYAPD---GILGLQLINGKN------------------ 276
Query: 294 DHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSC-GSAQIWQHGTSLMNYLR 352
SA + DAV V AV EL + I P C G+ IW+ G L
Sbjct: 277 ----------ESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLM 326
Query: 353 MVEL-EGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLY-----A 406
+ +G+TG +EFN G R I+ Q+G ++ + D +
Sbjct: 327 SSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGET 386
Query: 407 SNISDTLFNTTLVVTTILENPYLMLK-------------------------GNHQEMEGN 441
+T L + TI + P++ +K G + G+
Sbjct: 387 EKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGS 446
Query: 442 DRYE------GFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGT-----WTGMVGELI 490
R+ GFC+D+L +LA + F Y++ LV DG +G E W GM+GEL+
Sbjct: 447 PRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELL 506
Query: 491 ARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLF 550
+ +AD+ VA LTI ER + I+FSKPF G++IL + + R SF+ PF +WL
Sbjct: 507 SGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRST-LDSFMQPFQSTLWLL 565
Query: 551 MLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQG-S 609
+ L+ V+ +L+L+ R +P+ + + + + +L +++WF G + G
Sbjct: 566 VGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEE-----DALTLSSAMWFSWGVLLNSGIG 620
Query: 610 TIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIE--- 666
APR+ S R + VW F +II++SYTANLAAFL + R + I ++D + +
Sbjct: 621 EGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFI 680
Query: 667 YGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVL-NSNYAFLLEST 725
Y T+ S +F+ Q + MY +S E I V N +AF+ +S
Sbjct: 681 YATVKQSSVDIYFRR------QVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSA 734
Query: 726 MNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWE 785
+ E+ + C+L G L G+GIGM S ++ L+IL+ EN +E L + W
Sbjct: 735 VLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVR 794
Query: 786 GGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEA 836
+C + A L EN+ G+F+++ G++ IF+ +E + RH +A
Sbjct: 795 YQECDSRSNAPAT-LTFENMAGVFMLVAGGIVAGIFLIFIEIAYK-RHKDA 843
>gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor
[Homo sapiens]
Length = 1336
Score = 179 bits (454), Expect = 1e-44
Identities = 134/462 (29%), Positives = 234/462 (50%), Gaps = 55/462 (11%)
Query: 445 EGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTIT 504
+GFC+D+LK LA + F+Y + LV +G +G + +G W GM+GE+ ++AD+A+ LTI
Sbjct: 485 KGFCIDILKRLAHTIGFSYDLYLVTNGKHG-KKIDGVWNGMIGEVFYQRADMAIGSLTIN 543
Query: 505 AEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPGVWLFMLLAYLAVSCV 561
ER +++DFS PF+ GIS++ + R G S FL+P+SP VW+ M + L V V
Sbjct: 544 EERSEIVDFSVPFVETGISVM----VARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAV 599
Query: 562 LFLVARLTPYEWYSP----HPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIA-PRAL 616
+ +E+ SP A G+ + +++G S+W + PR
Sbjct: 600 TVFI-----FEYLSPVGYNRSLATGK-RPGGSTFTIGKSIWLLWALVFNNSVPVENPRGT 653
Query: 617 STRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQ---------TAIEY 667
+++ + VW F +I ++SYTANLAAF+ + +++V L+D+ +++
Sbjct: 654 TSKIMVLVWAFFAVIFLASYTANLAAFMIQEEY---VDTVSGLSDRKFQRPQEQYPPLKF 710
Query: 668 GTIHGGSSMTFFQNSRYQTYQRMWNYMYS-KQPSVFVKSTEEGIARVLNSNY-AFLLEST 725
GT+ GS+ + + Y M +YM QP V EE + ++ AF+ ++
Sbjct: 711 GTVPNGST----EKNIRSNYPDMHSYMVRYNQPRV-----EEALTQLKAGKLDAFIYDAA 761
Query: 726 MNEYYRQRN--CNLTQIGG--LLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKR 781
+ Y +++ C L IG + T GYGI + GS ++ DLA+LQ ++ +E+L+R
Sbjct: 762 VLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLER 821
Query: 782 KWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFL--WTLRHSEATEV 839
W G + + + L ++N+ G+F +L+ + +++ + E L W LRH
Sbjct: 822 LWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTH 881
Query: 840 SVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRP 881
+ ++ R + C + AA PP +PP P + P
Sbjct: 882 RM-DFLLAFSRGMYSCCSA------EAAPPPAKPPPPPQPLP 916
>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
precursor [Homo sapiens]
Length = 1281
Score = 176 bits (446), Expect = 9e-44
Identities = 125/446 (28%), Positives = 218/446 (48%), Gaps = 47/446 (10%)
Query: 445 EGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTIT 504
+GFC+D+LK+L+ ++F Y + LV +G +G + N W GM+GE++ ++A +AV LTI
Sbjct: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHG-KKVNNVWNGMIGEVVYQRAVMAVGSLTIN 515
Query: 505 AEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPGVWLFMLLAYLAVSCV 561
ER +V+DFS PF+ GIS++ + R G S FL+PFS VW+ M + L VS +
Sbjct: 516 EERSEVVDFSVPFVETGISVM----VSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAI 571
Query: 562 LFLVARLTPYEWYSP----HPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIA-PRAL 616
V +E++SP A+G+ +++G ++W G + P+
Sbjct: 572 AVFV-----FEYFSPVGYNRNLAKGKAP-HGPSFTIGKAIWLLWGLVFNNSVPVQNPKGT 625
Query: 617 STRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEY------GTI 670
+++ + VW F +I ++SYTANLAAF+ + + + D Q +Y GT+
Sbjct: 626 TSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTV 685
Query: 671 HGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNY-AFLLESTMNEY 729
GS+ +N+ + YM+ K E+ + + AF+ ++ + Y
Sbjct: 686 PNGSTERNIRNN--------YPYMHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNY 737
Query: 730 Y--RQRNCNLTQIGG--LLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWE 785
R C L IG + T GYGI + GS ++ + DLA+LQ + +E L+ W
Sbjct: 738 KAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLT 797
Query: 786 GGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLE--FLWTLRHSEATEVSVCQ 843
G ++ + + L ++N+ G+F +L + +++ + E F W LR VC
Sbjct: 798 GICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRF---CFTGVCS 854
Query: 844 E----MVTELRSIILCQDSIHPRRRR 865
+ + + R I C +H ++
Sbjct: 855 DRPGLLFSISRGIYSCIHGVHIEEKK 880
>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 176 bits (446), Expect = 9e-44
Identities = 125/446 (28%), Positives = 218/446 (48%), Gaps = 47/446 (10%)
Query: 445 EGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTIT 504
+GFC+D+LK+L+ ++F Y + LV +G +G + N W GM+GE++ ++A +AV LTI
Sbjct: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHG-KKVNNVWNGMIGEVVYQRAVMAVGSLTIN 515
Query: 505 AEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPGVWLFMLLAYLAVSCV 561
ER +V+DFS PF+ GIS++ + R G S FL+PFS VW+ M + L VS +
Sbjct: 516 EERSEVVDFSVPFVETGISVM----VSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAI 571
Query: 562 LFLVARLTPYEWYSP----HPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIA-PRAL 616
V +E++SP A+G+ +++G ++W G + P+
Sbjct: 572 AVFV-----FEYFSPVGYNRNLAKGKAP-HGPSFTIGKAIWLLWGLVFNNSVPVQNPKGT 625
Query: 617 STRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEY------GTI 670
+++ + VW F +I ++SYTANLAAF+ + + + D Q +Y GT+
Sbjct: 626 TSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTV 685
Query: 671 HGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNY-AFLLESTMNEY 729
GS+ +N+ + YM+ K E+ + + AF+ ++ + Y
Sbjct: 686 PNGSTERNIRNN--------YPYMHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNY 737
Query: 730 Y--RQRNCNLTQIGG--LLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWE 785
R C L IG + T GYGI + GS ++ + DLA+LQ + +E L+ W
Sbjct: 738 KAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLT 797
Query: 786 GGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLE--FLWTLRHSEATEVSVCQ 843
G ++ + + L ++N+ G+F +L + +++ + E F W LR VC
Sbjct: 798 GICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRF---CFTGVCS 854
Query: 844 E----MVTELRSIILCQDSIHPRRRR 865
+ + + R I C +H ++
Sbjct: 855 DRPGLLFSISRGIYSCIHGVHIEEKK 880
>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 176 bits (446), Expect = 9e-44
Identities = 125/446 (28%), Positives = 218/446 (48%), Gaps = 47/446 (10%)
Query: 445 EGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTIT 504
+GFC+D+LK+L+ ++F Y + LV +G +G + N W GM+GE++ ++A +AV LTI
Sbjct: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHG-KKVNNVWNGMIGEVVYQRAVMAVGSLTIN 515
Query: 505 AEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPGVWLFMLLAYLAVSCV 561
ER +V+DFS PF+ GIS++ + R G S FL+PFS VW+ M + L VS +
Sbjct: 516 EERSEVVDFSVPFVETGISVM----VSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAI 571
Query: 562 LFLVARLTPYEWYSP----HPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIA-PRAL 616
V +E++SP A+G+ +++G ++W G + P+
Sbjct: 572 AVFV-----FEYFSPVGYNRNLAKGKAP-HGPSFTIGKAIWLLWGLVFNNSVPVQNPKGT 625
Query: 617 STRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEY------GTI 670
+++ + VW F +I ++SYTANLAAF+ + + + D Q +Y GT+
Sbjct: 626 TSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTV 685
Query: 671 HGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNY-AFLLESTMNEY 729
GS+ +N+ + YM+ K E+ + + AF+ ++ + Y
Sbjct: 686 PNGSTERNIRNN--------YPYMHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNY 737
Query: 730 Y--RQRNCNLTQIGG--LLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWE 785
R C L IG + T GYGI + GS ++ + DLA+LQ + +E L+ W
Sbjct: 738 KAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLT 797
Query: 786 GGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLE--FLWTLRHSEATEVSVCQ 843
G ++ + + L ++N+ G+F +L + +++ + E F W LR VC
Sbjct: 798 GICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRF---CFTGVCS 854
Query: 844 E----MVTELRSIILCQDSIHPRRRR 865
+ + + R I C +H ++
Sbjct: 855 DRPGLLFSISRGIYSCIHGVHIEEKK 880
>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor
[Homo sapiens]
Length = 1233
Score = 176 bits (446), Expect = 9e-44
Identities = 163/643 (25%), Positives = 290/643 (45%), Gaps = 113/643 (17%)
Query: 314 AVVTAVQELNRSQEI--GVKPLSCGSAQIW-QHGT--------------------SLMNY 350
+VVT L+ Q++ GV L+ G+ W QHGT + +
Sbjct: 275 SVVTESWRLSLRQKVRDGVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRH 334
Query: 351 LRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNG-FRQIGQWHVAEGLSMDSH----LY 405
L V EG F+ G + ++ R+ + +G+W G+ + Y
Sbjct: 335 LLNVTWEGRD--FSFSPGGYLVQPTMVVIALNRHRLWEMVGRWE--HGVLYMKYPVWPRY 390
Query: 406 ASNISDTLFNTTLVVTTILENPYLMLKG-------------------NHQEMEGNDR--- 443
++++ + + L V T+ E P+++++ NH G+
Sbjct: 391 SASLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVAPYT 450
Query: 444 ---YEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAG 500
+GFC+D+LK+LA +++F+Y + LV +G +G G W GM+GE+ ++AD+A+
Sbjct: 451 KLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHG-KRVRGVWNGMIGEVYYKRADMAIGS 509
Query: 501 LTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPGVWLFMLLAYLA 557
LTI ER +++DFS PF+ GIS++ + R G S FL+P+SP VW+ M
Sbjct: 510 LTINEERSEIVDFSVPFVETGISVM----VARSNGTVSPSAFLEPYSPAVWVMMF----- 560
Query: 558 VSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQ------YSLGNSLWFPVGGFMQQGSTI 611
V C+ + + +E++SP Q NL + +++G S+W I
Sbjct: 561 VMCLTVVAITVFMFEYFSPVSYNQ---NLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPI 617
Query: 612 A-PRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQ-------- 662
PR +++ + VW F +I ++SYTANLAAF+ ++ I++V L+D+
Sbjct: 618 ENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQY---IDTVSGLSDKKFQRPQDQ 674
Query: 663 -TAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARV-LNSNYAF 720
+GT+ GS+ + + Y+ M +M +S E+ + + + AF
Sbjct: 675 YPPFRFGTVPNGST----ERNIRSNYRDMHTHMVKFNQ----RSVEDALTSLKMGKLDAF 726
Query: 721 LLESTMNEYY--RQRNCNLTQIGG--LLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRL 776
+ ++ + Y + C L IG + T GYGI M S ++ DLA+LQ +
Sbjct: 727 IYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGET 786
Query: 777 EILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFL--WTLRHS 834
+ L+ W G ++ + + L ++N+ G+F +L+ + +A+ + E L W LRHS
Sbjct: 787 QKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHS 846
Query: 835 EATEVSVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPE 877
S ++ R I C + ++ PPR P+
Sbjct: 847 -VPNSSQLDFLLAFSRGIYSCFSGV-----QSLASPPRQASPD 883
>gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor
[Homo sapiens]
Length = 1484
Score = 174 bits (441), Expect = 4e-43
Identities = 132/455 (29%), Positives = 223/455 (49%), Gaps = 53/455 (11%)
Query: 445 EGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTIT 504
+GFC+D+LK++++ ++F Y + LV +G +G + NGTW GM+GE++ ++A +AV LTI
Sbjct: 458 KGFCIDILKKISKSVKFTYDLYLVTNGKHG-KKINGTWNGMIGEVVMKRAYMAVGSLTIN 516
Query: 505 AEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPGVWLFMLLAYLAVSCV 561
ER +V+DFS PF+ GIS++ + R G S FL+PFS VW+ M + L VS V
Sbjct: 517 EERSEVVDFSVPFIETGISVM----VSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAV 572
Query: 562 LFLVARLTPYEWYSP---HPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIA-PRALS 617
V +E++SP + C +++G ++W G + P+ +
Sbjct: 573 AVFV-----FEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTT 627
Query: 618 TRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQ---------TAIEYG 668
++ + VW F +I ++SYTANLAAF+ + ++ V L+D+ +G
Sbjct: 628 SKIMVSVWAFFAVIFLASYTANLAAFMIQEEY---VDQVSGLSDKKFQRPNDFSPPFRFG 684
Query: 669 TIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNY-----AFLLE 723
T+ GS+ +N+ Y M YM K + G+ L S AF+ +
Sbjct: 685 TVPNGSTERNIRNN----YAEMHAYM--------GKFNQRGVDDALLSLKTGKLDAFIYD 732
Query: 724 STMNEYY--RQRNCNLTQIGG--LLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEIL 779
+ + Y R C L IG + + GYGI + S ++ + DLAILQL + +E L
Sbjct: 733 AAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEEL 792
Query: 780 KRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLE--FLWTLRHSEAT 837
+ W G ++ + + L ++N+ G+F +L + +++ + E F W RH
Sbjct: 793 EALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFRHCFMG 852
Query: 838 EVSVCQEMVTEL-RSIILCQDSIHPRRRRAAVPPP 871
S MV + R I C + R++ + P
Sbjct: 853 VCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSP 887
>gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
[Homo sapiens]
Length = 1043
Score = 150 bits (379), Expect = 5e-36
Identities = 109/393 (27%), Positives = 187/393 (47%), Gaps = 30/393 (7%)
Query: 446 GFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITA 505
G+C+D+L+ LAE F++++ LVGDG YG +G WTG+VG+L+A +A +AV +I +
Sbjct: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALR-DGRWTGLVGDLLAGRAHMAVTSFSINS 536
Query: 506 EREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLV 565
R +V+DF+ PF + + I+ R P +W +L V L L
Sbjct: 537 ARSQVVDFTSPFFSTSLGIMVRAR--------DTASPIGAFMWPLHWSTWLGVFAALHLT 588
Query: 566 AR-LTPYEWYSPHPCA-QGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSG 623
A LT YEW SP+ +GR V YS +L + + F + S+ P+ + R +
Sbjct: 589 ALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAI-LFRRTVSSKTPKCPTGRLLMN 647
Query: 624 VWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLA---DQTAIEYGTIHGGSSMTFFQ 680
+W F L+++SSYTANLAA + + + + D +GT+ S+ + +
Sbjct: 648 LWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIK 707
Query: 681 NSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSN---YAFLLESTMNEY--YRQRNC 735
S + M + +T G+A + + AF+++ ++ +Y +C
Sbjct: 708 KSFPDMHAHMRRHS--------APTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADC 759
Query: 736 NLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEEDH 795
L +G +GYGIG+P S I + + + +++L KW++ C K
Sbjct: 760 KLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFA 819
Query: 796 RAKGLGME--NIGGIFVVLICGLIVAIFMAMLE 826
+ L M + G+FV+L GL A+ ++ E
Sbjct: 820 VTETLQMSIYHFAGLFVLLCLGLGSALLSSLGE 852
>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate
3A [Homo sapiens]
Length = 1115
Score = 147 bits (370), Expect = 6e-35
Identities = 109/397 (27%), Positives = 194/397 (48%), Gaps = 34/397 (8%)
Query: 446 GFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITA 505
G+C+D+L+++AE + F++ + +VGDG YG + NG WTG+VG+L+ A +AV +I
Sbjct: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWK-NGHWTGLVGDLLRGTAHMAVTSFSINT 636
Query: 506 EREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLV 565
R +VIDF+ PF + + IL R P +F+ P +WL + +A L ++ V
Sbjct: 637 ARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMWLGIFVA-LHITAVF--- 691
Query: 566 ARLTPYEWYSPHPCA-QGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIA---PRALSTRCV 621
LT YEW SP +GR V +S ++ + + G T+A P+ + R +
Sbjct: 692 --LTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYA----LLFGRTVAIKPPKCWTGRFL 745
Query: 622 SGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLA---DQTAIEYGTIHGGSSMTF 678
+W F + +S+YTANLAA + +++ + + D +GT+ S+ +
Sbjct: 746 MNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDY 805
Query: 679 FQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNY---AFLLESTMNEY--YRQR 733
+ S + ++ M Y V +T +G+ + N AF+++ + +Y
Sbjct: 806 VRQSFPEMHEYMRRYN--------VPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDA 857
Query: 734 NCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEE 793
+C L +G +GYGIG+P S I Q + + +++L KW+ C K
Sbjct: 858 DCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRS 917
Query: 794 DHRAKGL--GMENIGGIFVVLICGLIVAIFMAMLEFL 828
+ L G+++ G+FV+L G ++I + E +
Sbjct: 918 FAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHI 954
>gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3
precursor [Homo sapiens]
Length = 433
Score = 76.3 bits (186), Expect = 1e-13
Identities = 61/241 (25%), Positives = 105/241 (43%), Gaps = 20/241 (8%)
Query: 203 LLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDR 262
LL+E+ + +I IL + +G Y YI NL F ++ +
Sbjct: 197 LLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGG 256
Query: 263 VNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTG----PALSSALLFDAVYAVVTA 318
N+ GF + + F L W++ D + G P +SAL +D V +
Sbjct: 257 ANVTGFQLVD----FNTPMVIKLMDRWKK-LDQREYPGSETPPKYTSALTYDGVLVMAET 311
Query: 319 VQELNRSQEIGVKPLS------CGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRS 372
+ L R Q+I + A W G + L+ V ++GLTG+++F+ G+R
Sbjct: 312 FRSLRR-QKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRV 370
Query: 373 NYALKILQFTRNGFRQIGQWHVAEGLSMDSHL-YASNISDTLFNTTLVVTTI---LENPY 428
NY + + + G R++G W+ + L + + N + + N T+VVTTI ++NP
Sbjct: 371 NYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVTTIMPLMKNPI 430
Query: 429 L 429
L
Sbjct: 431 L 431
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,685,373
Number of Sequences: 37866
Number of extensions: 1585420
Number of successful extensions: 5603
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 5384
Number of HSP's gapped (non-prelim): 64
length of query: 956
length of database: 18,247,518
effective HSP length: 112
effective length of query: 844
effective length of database: 14,006,526
effective search space: 11821507944
effective search space used: 11821507944
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.