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Search of human proteins with 28875799
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28875799 cholecystokinin B receptor [Homo sapiens]
(447 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28875799 cholecystokinin B receptor [Homo sapiens] 894 0.0
gi|4502607 cholecystokinin A receptor [Homo sapiens] 385 e-107
gi|222080109 orexin receptor 2 [Homo sapiens] 155 5e-38
gi|222080095 orexin receptor 1 [Homo sapiens] 144 2e-34
gi|5453796 neuropeptide Y receptor Y5 [Homo sapiens] 122 5e-28
gi|62865887 G protein-coupled receptor 54 [Homo sapiens] 122 7e-28
gi|4507681 thyrotropin-releasing hormone receptor [Homo sapiens] 122 9e-28
gi|149944554 somatostatin receptor 4 [Homo sapiens] 121 1e-27
gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens] 120 3e-27
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 118 1e-26
gi|4502333 arginine vasopressin receptor 1B [Homo sapiens] 117 2e-26
gi|11545887 neuropeptide FF receptor 1 [Homo sapiens] 115 8e-26
gi|16604258 neuropeptide FF receptor 2 isoform 2 [Homo sapiens] 114 1e-25
gi|221316654 neuropeptide FF receptor 2 isoform 1 [Homo sapiens] 114 1e-25
gi|221316652 neuropeptide FF receptor 2 isoform 3 [Homo sapiens] 114 1e-25
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 113 3e-25
gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa... 109 4e-24
gi|188497623 neuromedin U receptor 1 [Homo sapiens] 109 4e-24
gi|4505447 neuropeptide Y receptor Y2 [Homo sapiens] 108 8e-24
gi|4505445 neuropeptide Y receptor Y1 [Homo sapiens] 108 1e-23
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] 108 1e-23
gi|157738685 G protein-coupled receptor 103 [Homo sapiens] 107 3e-23
gi|4503907 galanin receptor 3 [Homo sapiens] 106 4e-23
gi|4758474 G protein-coupled receptor 10 [Homo sapiens] 103 3e-22
gi|7669548 tachykinin receptor 3 [Homo sapiens] 102 9e-22
gi|4503905 galanin receptor 2 [Homo sapiens] 100 3e-21
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 100 3e-21
gi|63477962 opioid receptor, delta 1 [Homo sapiens] 100 3e-21
gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo s... 98 2e-20
gi|157426873 tachykinin receptor 2 [Homo sapiens] 97 3e-20
>gi|28875799 cholecystokinin B receptor [Homo sapiens]
Length = 447
Score = 894 bits (2309), Expect = 0.0
Identities = 447/447 (100%), Positives = 447/447 (100%)
Query: 1 MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL 60
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL
Sbjct: 1 MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL 60
Query: 61 YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF 120
YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
Sbjct: 61 YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF 120
Query: 121 IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL 180
IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL
Sbjct: 121 IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL 180
Query: 181 LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL 240
LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL
Sbjct: 181 LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL 240
Query: 241 ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS 300
ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS
Sbjct: 241 ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS 300
Query: 301 RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG 360
RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG
Sbjct: 301 RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG 360
Query: 361 PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL 420
PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL
Sbjct: 361 PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL 420
Query: 421 PDEDPPTPSIASLSRLSYTTISTLGPG 447
PDEDPPTPSIASLSRLSYTTISTLGPG
Sbjct: 421 PDEDPPTPSIASLSRLSYTTISTLGPG 447
>gi|4502607 cholecystokinin A receptor [Homo sapiens]
Length = 428
Score = 385 bits (989), Expect = e-107
Identities = 212/413 (51%), Positives = 274/413 (66%), Gaps = 37/413 (8%)
Query: 49 TRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACM 108
++E + A++I LY++IFL+SV GN L+I VL ++R+RTVTN FLLSLAVSDL+L + CM
Sbjct: 36 SKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCM 95
Query: 109 PFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTR 168
PF L+PNL+ FIFG+ +CK +Y MG SVSVST +LVAI+LERY AIC+PLQ+RVWQT+
Sbjct: 96 PFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTK 155
Query: 169 SHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQ----CVHRWPSARVRQTWSVLLLL 224
SHA +VI ATW LS +M PYP+Y+ + P Q C P+ ++Q+W LLL
Sbjct: 156 SHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLL 215
Query: 225 LLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETG 284
+LF IPG+VM VAYGLIS ELY G++F+ ++ R +P T
Sbjct: 216 ILFLIPGIVMMVAYGLISLELYQGIKFEASQKKSAKER-----------------KPSTT 258
Query: 285 AVG--EDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQ-------AKLLAKKRVVRML 335
+ G EDSDGCY+Q R LEL L+ GS SR + A L+AKKRV+RML
Sbjct: 259 SSGKYEDSDGCYLQKTRPPRKLELRQLST---GSSSRANRIRSNSSAANLMAKKRVIRML 315
Query: 336 LVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHR 395
+VIVVLFFLCW+P++SAN WRA+D A R LSG PISFI LLSY S+CVNP++YCFM++
Sbjct: 316 IVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNK 375
Query: 396 RFRQACLETCARCCPR--PPRARPRALPDEDPPTPSIASLSRLSYTTISTLGP 446
RFR + T CCP PP AR +E+ T ASLSR SY+ +S P
Sbjct: 376 RFRLGFMATFP-CCPNPGPPGARGEVGEEEEGGTTG-ASLSRFSYSHMSASVP 426
>gi|222080109 orexin receptor 2 [Homo sapiens]
Length = 444
Score = 155 bits (393), Expect = 5e-38
Identities = 101/369 (27%), Positives = 179/369 (48%), Gaps = 56/369 (15%)
Query: 56 IRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPN 115
+ I Y ++F++++ GN+L+ V + + +RTVTN F+++L+++D+L+ + C+P TL+ +
Sbjct: 56 VLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVD 115
Query: 116 LMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVI 175
+ T+ FG +CK + YL VSVSVS L+L IAL+R+ AIC PL + T A I
Sbjct: 116 ITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFK--STAKRARNSI 173
Query: 176 VATWLLSGLLMVPYPVYTVVQPVGPRVLQ-------CVHRWPSARVRQTWSVLLLLLLFF 228
V W++S ++M+P + V P + C RW + + + L+ +
Sbjct: 174 VIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYM 233
Query: 229 IPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGE 288
P +M +AY I R+L+ CR G
Sbjct: 234 APLCLMVLAYLQIFRKLW--------------------------------CRQIPGTSS- 260
Query: 289 DSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQA-----KLLAKKRVVRMLLVIVVLFF 343
V + +P ++ PG + SR + ++ A+++ RML++++++F
Sbjct: 261 ------VVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFA 314
Query: 344 LCWLPVYSANTWRAFDGPGAH---RALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQA 400
+C+LP+ N + G AH R A +F H L YA++ NP++Y F+ +FR+
Sbjct: 315 ICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREE 374
Query: 401 CLETCARCC 409
+ CC
Sbjct: 375 FKAAFSCCC 383
>gi|222080095 orexin receptor 1 [Homo sapiens]
Length = 425
Score = 144 bits (362), Expect = 2e-34
Identities = 108/399 (27%), Positives = 188/399 (47%), Gaps = 46/399 (11%)
Query: 56 IRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPN 115
+ I Y +F++++ GN L+ + + + +RTVTN F+++L+++D+L+ C+P +LL +
Sbjct: 48 VLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVD 107
Query: 116 LMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVI 175
+ +++FG +CK + YL VSVSV+ L+L IAL+R+ AIC PL + T A I
Sbjct: 108 ITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFK--STARRARGSI 165
Query: 176 VATWLLSGLLMVPYPVYTVVQPVGPRVLQ-------CVHRWPSARVRQTWSVLLLLLLFF 228
+ W +S +MVP V P + C RW + + ++ +
Sbjct: 166 LGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYL 225
Query: 229 IPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGE 288
P +MA+AY I R+L+ G + G + + ++ R L E G GE
Sbjct: 226 APLGLMAMAYFQIFRKLW-GRQIPGTTSALVRNWKRPSDQLGDL---------EQGLSGE 275
Query: 289 DSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLP 348
PR+R L ++ A+++ +ML+V++++F LC+LP
Sbjct: 276 PQ-------PRARAFL---------------AEVKQMRARRKTAKMLMVVLLVFALCYLP 313
Query: 349 VYSANTWRAFDG---PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETC 405
+ N + G + R A +F H L YA++ NP++Y F+ +FR+
Sbjct: 314 ISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAF 373
Query: 406 ARCCP--RPPRARPRALPDEDPPTPSIASLSRLSYTTIS 442
+ C P P + P S++ SR S + IS
Sbjct: 374 SCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKIS 412
>gi|5453796 neuropeptide Y receptor Y5 [Homo sapiens]
Length = 445
Score = 122 bits (307), Expect = 5e-28
Identities = 96/394 (24%), Positives = 168/394 (42%), Gaps = 66/394 (16%)
Query: 58 ITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLM 117
I LY + L+ GN+LI++ L R +T N + +LA SD+L+ + C PFTL L+
Sbjct: 45 IGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLL 104
Query: 118 GTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVA 177
++FG V+C + +L VSV VSTL L++IA+ RY I P+ + T +H +I
Sbjct: 105 DQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNL--TANHGYFLIAT 162
Query: 178 TWLLSGLLMVPYPVY----TVVQPVGPRVLQ----CVHRWPSARVRQTWSVLLLLLLFFI 229
W L + P PV+ + + G +L CV WPS R +++ LLL+ + +
Sbjct: 163 VWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYIL 222
Query: 230 PGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGED 289
P V + V++ + R + GL S+ ++R+ + +H + + P+ G
Sbjct: 223 PLVCLTVSHTSVCRSISCGL-------SNKENRLEENEMINLTLHPSKKSGPQVKLSGSH 275
Query: 290 SDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLL----------------------- 326
R + TA P P S+ +++L
Sbjct: 276 KWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPT 335
Query: 327 ----------------AKKRVVRM----------LLVIVVLFFLCWLPVYSANTWRAFDG 360
K+ V R+ L +++++F + W+P++ + F+
Sbjct: 336 CFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFND 395
Query: 361 PGAHRALSGAPISFIHLLSYASACVNPLVYCFMH 394
HLL S C+NP++Y F++
Sbjct: 396 NLISNRHFKLVYCICHLLGMMSCCLNPILYGFLN 429
>gi|62865887 G protein-coupled receptor 54 [Homo sapiens]
Length = 398
Score = 122 bits (306), Expect = 7e-28
Identities = 102/379 (26%), Positives = 167/379 (44%), Gaps = 64/379 (16%)
Query: 61 YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF 120
+A + L+ + GN L+I V+ + +RTVTN ++ +LA +D+ + C+PFT L + +
Sbjct: 49 FAALMLLGLVGNSLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGW 108
Query: 121 IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL 180
+ G +CK V+Y+ VSV + +L A++++R+ PL+A +T A V ++ W+
Sbjct: 109 VLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWV 168
Query: 181 LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL 240
S + P + P GPR C +PS + + +++ LL L+ +P + Y
Sbjct: 169 GSAAVSAPVLALHRLSP-GPRA-YCSEAFPSRALERAFALYNLLALYLLPLLATCACYAA 226
Query: 241 ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS 300
+ R L +DS Q +V + GAV
Sbjct: 227 MLRHLGRVAVRPAPADSALQGQVLAE---------------RAGAV-------------- 257
Query: 301 RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG 360
R ++L+A +V+LF CW P+ +A
Sbjct: 258 ------------------RAKVSRLVA---------AVVLLFAACWGPIQLFLVLQALGP 290
Query: 361 PGAHRALSGAPI---SFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARP 417
G+ S A ++ H +SY+++ +NPL+Y F+ FRQA C C PR PR RP
Sbjct: 291 AGSWHPRSYAAYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCP-CAPRRPR-RP 348
Query: 418 RALPDEDPPTPSIASLSRL 436
R DP P A L RL
Sbjct: 349 RRPGPSDPAAPH-AELLRL 366
>gi|4507681 thyrotropin-releasing hormone receptor [Homo sapiens]
Length = 398
Score = 122 bits (305), Expect = 9e-28
Identities = 89/372 (23%), Positives = 176/372 (47%), Gaps = 63/372 (16%)
Query: 56 IRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPN 115
+ I L +I + + GN+++++V+ ++ +RT TN +L+SLAV+DL++ VA + +
Sbjct: 27 VTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDS 86
Query: 116 LMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVI 175
+ G++++G V C ++YL + ++ S+ S+ A +ERY AIC P++A+ T S A ++I
Sbjct: 87 IYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKII 146
Query: 176 VATWLLSGL------LMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLL---LL 226
+ W + L ++ + T + V+ C ++ R +S + L+ +
Sbjct: 147 IFVWAFTSLYCMLWFFLLDLNISTYKDAI---VISCGYKIS----RNYYSPIYLMDFGVF 199
Query: 227 FFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAV 286
+ +P ++ V YG I+R L+L + S + ++ + HQN T
Sbjct: 200 YVVPMILATVLYGFIARILFL-------NPIPSDPKENSKTWKNDSTHQNTNLNVNT--- 249
Query: 287 GEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCW 346
S+ C+ + + ++K+V +ML V+V+LF L W
Sbjct: 250 ---SNRCF---------------------------NSTVSSRKQVTKMLAVVVILFALLW 279
Query: 347 LPVYSANTWRAF-DGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETC 405
+P + +F P + F + Y ++ +NP++Y M ++FR A + C
Sbjct: 280 MPYRTLVVVNSFLSSPFQENWF----LLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLC 335
Query: 406 ARCCPRPPRARP 417
C + P +P
Sbjct: 336 N--CKQKPTEKP 345
>gi|149944554 somatostatin receptor 4 [Homo sapiens]
Length = 388
Score = 121 bits (303), Expect = 1e-27
Identities = 93/358 (25%), Positives = 163/358 (45%), Gaps = 87/358 (24%)
Query: 60 LYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGT 119
+YA++ L+ + GN L+I V+ +++T TN +LL+LAV+D L ++ +PF +
Sbjct: 53 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLS-VPFVASSAALRH 111
Query: 120 FIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATW 179
+ FG+V+C+AV + G+++ S L ++++RY A+ PL+A ++ S A + + W
Sbjct: 112 WPFGSVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVW 171
Query: 180 LLSGLLMVPYPVYTVVQPV-GPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAY 238
L S L+ +P ++ +P G + + C +WP WS + ++ F +
Sbjct: 172 LASLLVTLPIAIFADTRPARGGQAVACNLQWP----HPAWSAVFVVYTFLL--------- 218
Query: 239 GLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLP 298
G + L +GL CY+ +
Sbjct: 219 GFLLPVLAIGL-------------------------------------------CYLLIV 235
Query: 299 RSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAF 358
A+ L A Q + ++K++ R++L++VV+F LCW+P Y F
Sbjct: 236 GKMRAVALRA-----------GWQQRRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNLF 284
Query: 359 ----DGPGAHRALSGAPISFIHLLSYASACVNPLVYCFM---HRRFRQACLETCARCC 409
D H +L +LSYA++C NP++Y F+ RRF Q L C RCC
Sbjct: 285 VTSLDATVNHVSL---------ILSYANSCANPILYGFLSDNFRRFFQRVL--CLRCC 331
>gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]
Length = 462
Score = 120 bits (300), Expect = 3e-27
Identities = 117/446 (26%), Positives = 181/446 (40%), Gaps = 76/446 (17%)
Query: 16 GPGASLCRPGAPLLNSSSVGNLSCE---PPRIRGAGTRELELAIRITLYAVIFLMSVGGN 72
GP AS GA S V N S PPR + + LA + + + +V GN
Sbjct: 17 GPNAS----GAGERGSGGVANASGASWGPPRGQYSAGAVAGLA---AVVGFLIVFTVVGN 69
Query: 73 MLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSY 132
+L+++ + SR LR N FL+SLA +D+L+A MPF+L LM + FG V C
Sbjct: 70 VLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLA 129
Query: 133 LMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVY 192
L + + S + L AI+L+RY ++ + ++ + +T IVA WL+S ++ P V
Sbjct: 130 LDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVS 189
Query: 193 TVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLL-LFFIPGVVMAVAYGLISRELYLGLRF 251
QP G QC +TW +L + FF P ++M + Y I R L R
Sbjct: 190 LYRQPDGAAYPQC------GLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRT 243
Query: 252 DGDSDS----DSQSRVRNQG-GLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALE- 305
+ + D S G G +NG C P V D + R R AL
Sbjct: 244 LSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRR 303
Query: 306 -----------------------------LTALTAPGPG-----SGSRPTQAKL------ 325
LTA +PGPG + SR + L
Sbjct: 304 GGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRA 363
Query: 326 -----------LAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISF 374
+KR +L V++ +F LCW P + + + + G F
Sbjct: 364 RSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQ--VPGPLFKF 421
Query: 375 IHLLSYASACVNPLVYCFMHRRFRQA 400
+ Y ++ +NP++Y ++ FR++
Sbjct: 422 FFWIGYCNSSLNPVIYTVFNQDFRRS 447
>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
Length = 408
Score = 118 bits (295), Expect = 1e-26
Identities = 111/401 (27%), Positives = 168/401 (41%), Gaps = 57/401 (14%)
Query: 53 ELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTL 112
E A+ L A+ L +VGGN+L+IV + + RL+T+TN F+ SLA +DL++ + +P
Sbjct: 36 EAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAA 95
Query: 113 LPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAA 172
L G + G C+ + + + V+ S +L A+A++RY A+ PL+ T+ A
Sbjct: 96 TLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCAR 155
Query: 173 RVIVATWLLSGLLMVPYPVYTVVQPVG-----------PRVLQCVHRWPSARVRQTWSVL 221
+V W++S + P+ + VG PR P + + S
Sbjct: 156 TAVVLVWVVSAAVSFA-PIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFY 214
Query: 222 L-LLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCR 280
L LL++ F+ V VA +R+L L G + ++ P V G C
Sbjct: 215 LPLLVMLFVYARVFVVA----TRQLRLLRGELGRFPPEESPPAPSRSLAPAPV---GTCA 267
Query: 281 PETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVV 340
P G P G RP + L + R + L +I+
Sbjct: 268 PPEGV----------------------------PACGRRPARLLPLREHRALCTLGLIMG 299
Query: 341 LFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQA 400
F LCWLP + AN RA GP + G ++ L YA++ NPL+YC FR A
Sbjct: 300 TFTLCWLPFFLANVLRALGGPS---LVPGPAFLALNWLGYANSAFNPLIYC-RSPDFRSA 355
Query: 401 CLETCARCCPRPP-----RARPRALPDEDPPTPSIASLSRL 436
RC R P ARP P P S + RL
Sbjct: 356 FRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRL 396
>gi|4502333 arginine vasopressin receptor 1B [Homo sapiens]
Length = 424
Score = 117 bits (294), Expect = 2e-26
Identities = 104/384 (27%), Positives = 164/384 (42%), Gaps = 61/384 (15%)
Query: 50 RELELA-IRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACM 108
R+ ELA + I + A + +++ GGN+ +++ LG R R+ + F+L LA++DL +A+
Sbjct: 29 RDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVAL--- 85
Query: 109 PFTLLPNLMGTFIFG----TVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARV 164
F +LP L+ + ++C+AV YL +S+ ST L+A+ L+RY A+C PL++ +
Sbjct: 86 -FQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRS-L 143
Query: 165 WQTRSHAARVIVATWLLSGLLMVP----YPVYTVVQPVGPRVLQCVHRWP------SARV 214
Q +I A WLL+ + +P + + V+Q G VL C W R
Sbjct: 144 QQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQ--GSGVLDC---WADFGFPWGPRA 198
Query: 215 RQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVH 274
TW+ L +F +P ++ Y LI E+ L +V+ Q G
Sbjct: 199 YLTWTT---LAIFVLPVTMLTACYSLICHEICKNL------------KVKTQAWRVG--- 240
Query: 275 QNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRM 334
G R RP+ A T G S AK R V+M
Sbjct: 241 -GGGWR-----------------TWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKM 282
Query: 335 LLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMH 394
VIV+ + CW P +S W +D + + LL ++C NP +Y +
Sbjct: 283 TFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFN 342
Query: 395 RRFRQACLETCARCCPRPPRARPR 418
L A C PR R R
Sbjct: 343 SHLLPRPLRHLACCGGPQPRMRRR 366
>gi|11545887 neuropeptide FF receptor 1 [Homo sapiens]
Length = 430
Score = 115 bits (288), Expect = 8e-26
Identities = 71/202 (35%), Positives = 109/202 (53%), Gaps = 13/202 (6%)
Query: 55 AIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLP 114
A+ I YA+IFL+ + GN L+ ++ +R + TVTN F+L+LAVSDLL+ + CMP TL+
Sbjct: 44 AMFIVAYALIFLLCMVGNTLVCFIVLKNRHMHTVTNMFILNLAVSDLLVGIFCMPTTLVD 103
Query: 115 NLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARV 174
NL+ + F CK + G+SVS S +LVAIA+ER+ I P + ++ T A
Sbjct: 104 NLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKL--TLRKALVT 161
Query: 175 IVATWLLSGLLMVPYPVYTVVQ------PVGPR-----VLQCVHRWPSARVRQTWSVLLL 223
I W L+ L+M P V V V R + C WP +R+ ++ +L
Sbjct: 162 IAVIWALALLIMCPSAVTLTVTREEHHFMVDARNRSYPLYSCWEAWPEKGMRRVYTTVLF 221
Query: 224 LLLFFIPGVVMAVAYGLISREL 245
++ P ++ V Y I+R+L
Sbjct: 222 SHIYLAPLALIVVMYARIARKL 243
Score = 52.4 bits (124), Expect = 8e-07
Identities = 36/126 (28%), Positives = 56/126 (44%), Gaps = 9/126 (7%)
Query: 300 SRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYS---ANTWR 356
+R A +L P PG + RVV ML+++ + F L WLP+++ +
Sbjct: 237 ARIARKLCQAPGPAPGGEEAADPRASRRRARVVHMLVMVALFFTLSWLPLWALLLLIDYG 296
Query: 357 AFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFR---QACLETCARCCPRPP 413
P H A F H L++ ++ NP++Y + + FR QA AR CPRP
Sbjct: 297 QLSAPQLHLVTVYA-FPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFR--ARLCPRPS 353
Query: 414 RARPRA 419
+ A
Sbjct: 354 GSHKEA 359
>gi|16604258 neuropeptide FF receptor 2 isoform 2 [Homo sapiens]
Length = 420
Score = 114 bits (286), Expect = 1e-25
Identities = 92/364 (25%), Positives = 159/364 (43%), Gaps = 78/364 (21%)
Query: 55 AIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLP 114
AI I Y +IF + + GN ++ ++ ++ + TVTN F+L+LA+SDLL+ + CMP TLL
Sbjct: 46 AIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLD 105
Query: 115 NLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARV 174
N++ + FG +CK + G+SV+ S +LVAIA++R+ + P + ++ T A +
Sbjct: 106 NIIAGWPFGNTMCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKL--TIKTAFVI 163
Query: 175 IVATWLLSGLLMVPYPVYTVVQ-------------PVGPRVLQCVHRWPSARVRQTWSVL 221
I+ W+L+ +M P V VQ P V C WP+ +R+ ++ +
Sbjct: 164 IMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQNKTSP-VYWCREDWPNQEMRKIYTTV 222
Query: 222 LLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRP 281
L ++ P ++ + YG I L+ AV GR
Sbjct: 223 LFANIYLAPLSLIVIMYGRIGISLF-----------------------RAAVPHTGRKNQ 259
Query: 282 ETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVL 341
E V SR Q K++ +V +L +
Sbjct: 260 EQWHV------------------------------VSRKKQ-KIIKMLLIVALLFI---- 284
Query: 342 FFLCWLPVYSANTWRAFD--GPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQ 399
L WLP+++ + P + ++ F H L++ ++ VNP++Y F + FR+
Sbjct: 285 --LSWLPLWTLMMLSDYADLSPNELQIINIYIYPFAHWLAFGNSSVNPIIYGFFNENFRR 342
Query: 400 ACLE 403
E
Sbjct: 343 GFQE 346
>gi|221316654 neuropeptide FF receptor 2 isoform 1 [Homo sapiens]
Length = 522
Score = 114 bits (286), Expect = 1e-25
Identities = 92/364 (25%), Positives = 159/364 (43%), Gaps = 78/364 (21%)
Query: 55 AIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLP 114
AI I Y +IF + + GN ++ ++ ++ + TVTN F+L+LA+SDLL+ + CMP TLL
Sbjct: 148 AIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLD 207
Query: 115 NLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARV 174
N++ + FG +CK + G+SV+ S +LVAIA++R+ + P + ++ T A +
Sbjct: 208 NIIAGWPFGNTMCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKL--TIKTAFVI 265
Query: 175 IVATWLLSGLLMVPYPVYTVVQ-------------PVGPRVLQCVHRWPSARVRQTWSVL 221
I+ W+L+ +M P V VQ P V C WP+ +R+ ++ +
Sbjct: 266 IMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQNKTSP-VYWCREDWPNQEMRKIYTTV 324
Query: 222 LLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRP 281
L ++ P ++ + YG I L+ AV GR
Sbjct: 325 LFANIYLAPLSLIVIMYGRIGISLF-----------------------RAAVPHTGRKNQ 361
Query: 282 ETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVL 341
E V SR Q K++ +V +L +
Sbjct: 362 EQWHV------------------------------VSRKKQ-KIIKMLLIVALLFI---- 386
Query: 342 FFLCWLPVYSANTWRAFD--GPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQ 399
L WLP+++ + P + ++ F H L++ ++ VNP++Y F + FR+
Sbjct: 387 --LSWLPLWTLMMLSDYADLSPNELQIINIYIYPFAHWLAFGNSSVNPIIYGFFNENFRR 444
Query: 400 ACLE 403
E
Sbjct: 445 GFQE 448
>gi|221316652 neuropeptide FF receptor 2 isoform 3 [Homo sapiens]
Length = 423
Score = 114 bits (286), Expect = 1e-25
Identities = 92/364 (25%), Positives = 159/364 (43%), Gaps = 78/364 (21%)
Query: 55 AIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLP 114
AI I Y +IF + + GN ++ ++ ++ + TVTN F+L+LA+SDLL+ + CMP TLL
Sbjct: 49 AIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLD 108
Query: 115 NLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARV 174
N++ + FG +CK + G+SV+ S +LVAIA++R+ + P + ++ T A +
Sbjct: 109 NIIAGWPFGNTMCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKL--TIKTAFVI 166
Query: 175 IVATWLLSGLLMVPYPVYTVVQ-------------PVGPRVLQCVHRWPSARVRQTWSVL 221
I+ W+L+ +M P V VQ P V C WP+ +R+ ++ +
Sbjct: 167 IMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQNKTSP-VYWCREDWPNQEMRKIYTTV 225
Query: 222 LLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRP 281
L ++ P ++ + YG I L+ AV GR
Sbjct: 226 LFANIYLAPLSLIVIMYGRIGISLF-----------------------RAAVPHTGRKNQ 262
Query: 282 ETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVL 341
E V SR Q K++ +V +L +
Sbjct: 263 EQWHV------------------------------VSRKKQ-KIIKMLLIVALLFI---- 287
Query: 342 FFLCWLPVYSANTWRAFD--GPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQ 399
L WLP+++ + P + ++ F H L++ ++ VNP++Y F + FR+
Sbjct: 288 --LSWLPLWTLMMLSDYADLSPNELQIINIYIYPFAHWLAFGNSSVNPIIYGFFNENFRR 345
Query: 400 ACLE 403
E
Sbjct: 346 GFQE 349
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 113 bits (283), Expect = 3e-25
Identities = 95/363 (26%), Positives = 160/363 (44%), Gaps = 44/363 (12%)
Query: 62 AVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFI 121
A LM+V GN+L+I+ + +R L+TVTN F+++LAV+DLLL+ +PF+ ++G +
Sbjct: 104 AAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWA 163
Query: 122 FGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLL 181
FG C + + + + S LSL I+++RY + L+ T AA ++ W++
Sbjct: 164 FGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVV 223
Query: 182 SGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLI 241
+ L++ P+ +PV P R+ ++V + F++P V+ V Y +
Sbjct: 224 A-LVVSVGPLLGWKEPVPPD-----ERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRV 277
Query: 242 -------SRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCY 294
+R L G++ + S+ R+ +G GA GA G S +
Sbjct: 278 YVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGA----------DGAHGMRSAKGH 327
Query: 295 VQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANT 354
R +L + L K +K+ + L ++V +F LCW P +
Sbjct: 328 T----FRSSLSVRLL--------------KFSREKKAAKTLAIVVGVFVLCWFPFFFV-- 367
Query: 355 WRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPR 414
S I L Y ++CVNPL+Y R F++A L C R R
Sbjct: 368 -LPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR 426
Query: 415 ARP 417
RP
Sbjct: 427 RRP 429
>gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo
sapiens]
Length = 471
Score = 109 bits (273), Expect = 4e-24
Identities = 95/378 (25%), Positives = 174/378 (46%), Gaps = 40/378 (10%)
Query: 29 LNSSSVGNLSCE----PPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRR 84
++S + NLSCE P + +E + +T AV+ ++++ GN+L+I+ + L ++
Sbjct: 47 VDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLT--AVVIILTIAGNILVIMAVSLEKK 104
Query: 85 LRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMG-TFIFGTVICKAVSYLMGVSVSVSTL 143
L+ TN FL+SLA++D+LL MP ++L L G + + +C YL + + S +
Sbjct: 105 LQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIM 164
Query: 144 SLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVL 203
L AI+L+RY AI P+ + +R+ A I+A W +S + +P PV+ G +
Sbjct: 165 HLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVF------GLQDD 218
Query: 204 QCVHRWPSARVRQTWSVLL-LLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSR 262
V + S + VL+ + FFIP +M + Y L + L SD ++++
Sbjct: 219 SKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATL-CVSDLGTRAK 277
Query: 263 VRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQ 322
+ + LP + S + + PG +G R T
Sbjct: 278 LASFSFLPQSSLS------------------------SEKLFQRSIHREPGSYTGRR-TM 312
Query: 323 AKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYAS 382
+ +++ ++L ++ LF + W P + N + + GA ++ + Y S
Sbjct: 313 QSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLS 372
Query: 383 ACVNPLVYCFMHRRFRQA 400
+ VNPLVY ++ +R A
Sbjct: 373 SAVNPLVYTLFNKTYRSA 390
>gi|188497623 neuromedin U receptor 1 [Homo sapiens]
Length = 426
Score = 109 bits (273), Expect = 4e-24
Identities = 122/426 (28%), Positives = 180/426 (42%), Gaps = 85/426 (19%)
Query: 36 NLSCEPPRIRGAGTRELELAIRI-TLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLL 94
NL+ E R++ G ++ EL + I Y +IF++ GN L +V+ + +RT TN +L
Sbjct: 41 NLTDEALRLKYLGPQQTELFMPICATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLF 100
Query: 95 SLAVSDLLLAVACMPFTLLPNLMG-TFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERY 153
SLAVSDLL+ + +P L F+ G C + L + S L++ A+++ERY
Sbjct: 101 SLAVSDLLVLLVGLPLELYEMWHNYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERY 160
Query: 154 SAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPV-----GPRVLQCVHR 208
A+ PLQAR TR+H RV+ A W L+ L +P ++ + GP V
Sbjct: 161 VAVVHPLQARSMVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCM 220
Query: 209 WPSARVRQTWSVLLLLLLFF-IPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQG 267
R V LLFF +P +M+V Y L +GLR
Sbjct: 221 LVRPRALYNMVVQTTALLFFCLPMAIMSVLY------LLIGLRL---------------- 258
Query: 268 GLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLA 327
R E + +++ G RSR L Q
Sbjct: 259 ------------RRERLLLMQEAKGRGSAAARSRYTCRL---------------QQHDRG 291
Query: 328 KKRVVRMLLVIVVLFFLCWLPVYSANT-WRAFD--GPGAHRALSGAPISFIHLLS----Y 380
+++V +ML V+VV+F +CW P ++ W G H A +H++S Y
Sbjct: 292 RRQVTKMLFVLVVVFGICWAPFHADRVMWSVVSQWTDGLHLA-----FQHVHVISGIFFY 346
Query: 381 ASACVNPLVYCFMHRRFRQACLET--CARCCPRPPRARPRALPDEDPPTPSIASLSRLSY 438
+ NP++Y M RFR+ E CC R RPR S SLSR+
Sbjct: 347 LGSAANPVLYSLMSSRFRETFQEALCLGACC---HRLRPR---------HSSHSLSRM-- 392
Query: 439 TTISTL 444
TT STL
Sbjct: 393 TTGSTL 398
>gi|4505447 neuropeptide Y receptor Y2 [Homo sapiens]
Length = 381
Score = 108 bits (271), Expect = 8e-24
Identities = 69/213 (32%), Positives = 119/213 (55%), Gaps = 10/213 (4%)
Query: 40 EPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVS 99
EP I E+++ + I Y I L+ V GN L+I V+ + +RTVTN F+ +LAV+
Sbjct: 37 EPELIDSTKLIEVQVVL-ILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVA 95
Query: 100 DLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRP 159
DLL+ C+PFTL LMG + G V+C V Y G++V VST++L IAL+R+ I
Sbjct: 96 DLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYH 155
Query: 160 LQARVWQTRSHAARVIVATWLLSGLLMVPYPV---YTVVQPVGP-RVLQCVHRWPSAR-- 213
L++++ ++ + +I W +S LL P + Y++++ + ++ C +WP
Sbjct: 156 LESKI--SKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKS 213
Query: 214 -VRQTWSVLLLLLLFFIPGVVMAVAYGLISREL 245
+S+ LL+L+ +P +++ +Y I +L
Sbjct: 214 IYGTVYSLSSLLILYVLPLGIISFSYTRIWSKL 246
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/81 (25%), Positives = 42/81 (51%), Gaps = 1/81 (1%)
Query: 328 KKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNP 387
+++ +ML+ +VV+F + WLP+++ D + H+++ S NP
Sbjct: 263 RQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANP 322
Query: 388 LVYCFMHRRFRQACLETCARC 408
L+Y +M+ +R+A L + RC
Sbjct: 323 LLYGWMNSNYRKAFL-SAFRC 342
>gi|4505445 neuropeptide Y receptor Y1 [Homo sapiens]
Length = 384
Score = 108 bits (270), Expect = 1e-23
Identities = 66/200 (33%), Positives = 112/200 (56%), Gaps = 16/200 (8%)
Query: 52 LELAIRITL---YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACM 108
L LA+ TL Y + ++ V GN+ +I+++ + +R VTN +++L+ SDLL+A+ C+
Sbjct: 35 LPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCL 94
Query: 109 PFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTR 168
PFT + LM ++FG +CK ++ VS++VS SLV IA+ER+ I P R W+
Sbjct: 95 PFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP---RGWRPN 151
Query: 169 S-HAARVIVATWLLSGLLMVPYPVYTVV--QPVGPRVLQ-------CVHRWPSARVRQTW 218
+ HA I W+L+ +P+ +Y V+ +P L C ++PS R ++
Sbjct: 152 NRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSY 211
Query: 219 SVLLLLLLFFIPGVVMAVAY 238
+ LLL+L +F P + + Y
Sbjct: 212 TTLLLVLQYFGPLCFIFICY 231
Score = 48.5 bits (114), Expect = 1e-05
Identities = 29/73 (39%), Positives = 41/73 (56%), Gaps = 4/73 (5%)
Query: 329 KRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFI--HLLSYASACVN 386
KR+ MLL IVV F +CWLP+ NT FD A + F+ HL + S CVN
Sbjct: 259 KRINIMLLSIVVAFAVCWLPLTIFNT--VFDWNHQIIATCNHNLLFLLCHLTAMISTCVN 316
Query: 387 PLVYCFMHRRFRQ 399
P+ Y F+++ F++
Sbjct: 317 PIFYGFLNKNFQR 329
>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
Length = 465
Score = 108 bits (269), Expect = 1e-23
Identities = 106/434 (24%), Positives = 180/434 (41%), Gaps = 74/434 (17%)
Query: 35 GNLSCEPPRIRGAGTRELELAIRITLYAV-----IFLMSVGGNMLIIVVLGLSRRLRTVT 89
GN S G G R ++++TL V + L++V GN+L+I+ + SR L+
Sbjct: 24 GNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQ 83
Query: 90 NAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIA 149
N FL+SLA +D+L+A +PF+L +MG + FG C+ L + + S + L AI+
Sbjct: 84 NLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAIS 143
Query: 150 LERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTV--------VQPVGPR 201
L+RY +I + ++ + +T +I+ W++S ++ P P+ ++ QP PR
Sbjct: 144 LDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFP-PLISIEKKGGGGGPQPAEPR 202
Query: 202 VLQCVHRW--PSARVRQTWSVLLLLLLFFI------------------PGVVMAVAYGLI 241
+W S+ + ++ L+++L ++ P V A G
Sbjct: 203 CEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTE 262
Query: 242 SRELYLG-LRFDGDSDSDSQSRVRNQGGLPG-----------------------AVHQNG 277
R LG R G ++++ G PG A G
Sbjct: 263 RRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPG 322
Query: 278 RCRPETGAVGEDSDGCYV-----QLPRSRPALELTALTAPGPG------SGSRPTQAKLL 326
RPE G G+ LPR P A GPG + + + +
Sbjct: 323 PRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQN 382
Query: 327 AKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVN 386
+KR +L V++ +F +CW P + T A G R L F Y ++ +N
Sbjct: 383 REKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV-GCSVPRTL----FKFFFWFGYCNSSLN 437
Query: 387 PLVYCFMHRRFRQA 400
P++Y + FR+A
Sbjct: 438 PVIYTIFNHDFRRA 451
>gi|157738685 G protein-coupled receptor 103 [Homo sapiens]
Length = 431
Score = 107 bits (266), Expect = 3e-23
Identities = 59/195 (30%), Positives = 107/195 (54%), Gaps = 9/195 (4%)
Query: 63 VIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIF 122
+IF +++ GN L+ V+ S+ +RTVTN F+ SLA+SDLL+ C+P T+L N+ ++
Sbjct: 54 LIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLG 113
Query: 123 GTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLS 182
G ICK V ++ +V L++ IA+ER+ + P + + T A ++ WL++
Sbjct: 114 GAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVA 173
Query: 183 GLLMVPYPVYTVVQ-------PVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMA 235
++V P++ V Q + C+ W S ++ ++ +L++LF +P +VM
Sbjct: 174 --VIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVML 231
Query: 236 VAYGLISRELYLGLR 250
+ Y I EL++ R
Sbjct: 232 ILYSKIGYELWIKKR 246
Score = 45.1 bits (105), Expect = 1e-04
Identities = 29/118 (24%), Positives = 52/118 (44%), Gaps = 11/118 (9%)
Query: 300 SRPALELTALTAPGPGSGSRPTQAKLLAK-----KRVVRMLLVIVVLFFLCWLPVYSANT 354
S+ EL G GS R K ++K KR V M++ +V LF +CW P + +
Sbjct: 235 SKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHM 294
Query: 355 WRAFDGPGAHRALSGAPI----SFIHLLSYASACVNPLVYCFMHRRFRQACLETCARC 408
+ + I + + ++ ++++ NP+VY FM+ F++ L C
Sbjct: 295 MIEYS--NFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYC 350
>gi|4503907 galanin receptor 3 [Homo sapiens]
Length = 368
Score = 106 bits (265), Expect = 4e-23
Identities = 70/238 (29%), Positives = 125/238 (52%), Gaps = 14/238 (5%)
Query: 36 NLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVL-----GLSRRLRTVTN 90
N+S + P GA +A+ + ++A+IFL+ GN L++ VL + + T+
Sbjct: 6 NISLDSPGSVGA------VAVPV-VFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTD 58
Query: 91 AFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIAL 150
F+L+LAV+DL + C+PF + ++FG ++CKAV L+ +++ S+ +L A+++
Sbjct: 59 LFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSV 118
Query: 151 ERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWP 210
+RY A+ PL++R +T +A + WLL+ L PY Y G L CV W
Sbjct: 119 DRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALEL-CVPAWE 177
Query: 211 SARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGG 268
AR R+ V + +P V+++AYG R L+ + G + ++++ R + G
Sbjct: 178 DAR-RRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAG 234
>gi|4758474 G protein-coupled receptor 10 [Homo sapiens]
Length = 370
Score = 103 bits (257), Expect = 3e-22
Identities = 65/191 (34%), Positives = 111/191 (58%), Gaps = 5/191 (2%)
Query: 58 ITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLM 117
+ LY+V+ ++ + GN L+++V+ RRL VTN + +LA+SD+L+ AC+P TL
Sbjct: 64 VLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFE 123
Query: 118 GT-FIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIV 176
++FG +C V +L V+V VS +L IA++RY + PL+ R+ + +A ++
Sbjct: 124 PRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRI--SLRLSAYAVL 181
Query: 177 ATWLLSGLLMVPYPVYTVVQPVGPR-VLQCVHRWPS-ARVRQTWSVLLLLLLFFIPGVVM 234
A W LS +L +P V+T + P V C W S R RQ ++ LLL+ + +P +V+
Sbjct: 182 AIWALSAVLALPAAVHTYHVELKPHDVRLCEEFWGSQERQRQLYAWGLLLVTYLLPLLVI 241
Query: 235 AVAYGLISREL 245
++Y +S +L
Sbjct: 242 LLSYVRVSVKL 252
Score = 54.7 bits (130), Expect = 2e-07
Identities = 25/72 (34%), Positives = 40/72 (55%)
Query: 328 KKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNP 387
++R +L+V+VV+F +CWLP++ N R D G H L+ +SAC NP
Sbjct: 273 RRRTFCLLVVVVVVFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNP 332
Query: 388 LVYCFMHRRFRQ 399
+Y ++H FR+
Sbjct: 333 FIYAWLHDSFRE 344
>gi|7669548 tachykinin receptor 3 [Homo sapiens]
Length = 465
Score = 102 bits (253), Expect = 9e-22
Identities = 87/372 (23%), Positives = 161/372 (43%), Gaps = 96/372 (25%)
Query: 54 LAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLL 113
+A+ Y V+ ++V GN+++I ++ +R+RTVTN FL++LA SD +A +
Sbjct: 85 IALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFI 144
Query: 114 PNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAAR 173
L + FG C+ ++ +V S S+ AIA++RY AI PL+ R+ T +
Sbjct: 145 YALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKI-- 202
Query: 174 VIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSA-RVRQTWSVLLLLLLFFIPGV 232
VI + W+L+ LL P +Y+ + + R L C +WP + T+ +++++L++ P +
Sbjct: 203 VIGSIWILAFLLAFPQCLYSKTKVMPGRTL-CFVQWPEGPKQHFTYHIIVIILVYCFPLL 261
Query: 233 VMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDG 292
+M + Y ++ L+ G +P G+ D
Sbjct: 262 IMGITYTIVGITLW-------------------GGEIP----------------GDTCDK 286
Query: 293 CYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVY-- 350
+ QL R +++ ++++V+ F +CWLP +
Sbjct: 287 YHEQLKAKRKVVKM----------------------------MIIVVMTFAICWLPYHIY 318
Query: 351 --------SANTWRAFDGPGAHRALSGAPISFIHLLSY----ASACVNPLVYCFMHRRFR 398
N W+ I ++L S+ +S NP++YC +++RFR
Sbjct: 319 FILTAIYQQLNRWKY--------------IQQVYLASFWLAMSSTMYNPIIYCCLNKRFR 364
Query: 399 QACLETCARCCP 410
A + R CP
Sbjct: 365 -AGFKRAFRWCP 375
>gi|4503905 galanin receptor 2 [Homo sapiens]
Length = 387
Score = 100 bits (249), Expect = 3e-21
Identities = 63/201 (31%), Positives = 105/201 (52%), Gaps = 2/201 (0%)
Query: 46 GAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAV 105
G G E I L+A+IFL+ GN L++ VL + + TN F+L+L V+DL +
Sbjct: 17 GGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFIL 76
Query: 106 ACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVW 165
C+PF + ++FG+++CKAV +L+ +++ S+ +L A++L+RY AI PL +R
Sbjct: 77 CCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSREL 136
Query: 166 QTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLL 225
+T +A I W LS L PY Y Q + C W + R R+ + +
Sbjct: 137 RTPRNALAAIGLIWGLSLLFSGPYLSY-YRQSQLANLTVCHPAWSAPR-RRAMDICTFVF 194
Query: 226 LFFIPGVVMAVAYGLISRELY 246
+ +P +V+ + Y R L+
Sbjct: 195 SYLLPVLVLGLTYARTLRYLW 215
Score = 63.2 bits (152), Expect = 5e-10
Identities = 37/99 (37%), Positives = 53/99 (53%), Gaps = 7/99 (7%)
Query: 315 GSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISF 374
GSG+R AK++V RM+L++ LF LCW+P ++ F RA I
Sbjct: 224 GSGARR------AKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRI-L 276
Query: 375 IHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPP 413
HL+SYA++CVNP+VY + + FR+ CA R P
Sbjct: 277 SHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAP 315
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 100 bits (248), Expect = 3e-21
Identities = 106/425 (24%), Positives = 178/425 (41%), Gaps = 59/425 (13%)
Query: 15 PGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNML 74
PG G + P AP + +S T ++ + L +IF +V GN
Sbjct: 6 PGQGNNTTSPPAPFETGGNTTGISDV--------TVSYQVITSLLLGTLIFC-AVLGNAC 56
Query: 75 IIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLM 134
++ + L R L+ V N + SLAV+DL+++V +P L ++ + G V C L
Sbjct: 57 VVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALD 116
Query: 135 GVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTV 194
+ + S L L AIAL+RY AI P+ +T AA +I TWL+ L+ +P
Sbjct: 117 VLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIP------ 170
Query: 195 VQPVGPRVLQCVHRWPSARVRQT--WSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFD 252
+G R + + + + +++ F+IP ++M V YG I R +R
Sbjct: 171 -PMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKT 229
Query: 253 GDSDSDSQSRVRNQGGLP-------------------GAVHQNGRCRPETGAVGEDSDGC 293
+ + R+ G P G + G GAV + DG
Sbjct: 230 VKKVEKTGADTRH-GASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGA 288
Query: 294 YVQL------PRSRPALELTALTAPGPGS-------GSRPTQAK----LLAKKRVVRMLL 336
+++ S+ L L + P P + R +AK L +++ V+ L
Sbjct: 289 ALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLG 348
Query: 337 VIVVLFFLCWLPVYSANTWRAFDGPGAHR-ALSGAPISFIHLLSYASACVNPLVYCFMHR 395
+I+ F LCWLP + F H L GA I+ L Y+++ +NP++Y + ++
Sbjct: 349 IIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGA---IINWLGYSNSLLNPVIYAYFNK 405
Query: 396 RFRQA 400
F+ A
Sbjct: 406 DFQNA 410
>gi|63477962 opioid receptor, delta 1 [Homo sapiens]
Length = 372
Score = 100 bits (248), Expect = 3e-21
Identities = 69/237 (29%), Positives = 125/237 (52%), Gaps = 15/237 (6%)
Query: 33 SVGNLSCEPPRIRGAGTRELELAIRIT-LYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNA 91
S G + PP R A + L LAI IT LY+ + + + GN+L++ + +++T TN
Sbjct: 29 SAGANASGPPGARSASS--LALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNI 86
Query: 92 FLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALE 151
++ +LA++D L A + +PF LM T+ FG ++CKAV + ++ S +L ++++
Sbjct: 87 YIFNLALADAL-ATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVD 145
Query: 152 RYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPS 211
RY A+C P++A ++T + A + + W+L+ + VP V V +P V+ C+ ++PS
Sbjct: 146 RYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVV-CMLQFPS 204
Query: 212 ARVRQTW------SVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSR 262
+W + + L F +P +++ V YGL+ L G + D R
Sbjct: 205 ----PSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLR 257
Score = 52.8 bits (125), Expect = 6e-07
Identities = 30/98 (30%), Positives = 49/98 (50%), Gaps = 5/98 (5%)
Query: 316 SGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYS-ANTWRAFDGPGAHRALSGAPISF 374
SGS+ L +R+ RM+LV+V F +CW P++ W D L A +
Sbjct: 247 SGSKEKDRSL---RRITRMVLVVVGAFVVCWAPIHIFVIVWTLVD-IDRRDPLVVAALHL 302
Query: 375 IHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRP 412
L YA++ +NP++Y F+ F++ + C + C RP
Sbjct: 303 CIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRP 340
>gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo
sapiens]
Length = 481
Score = 97.8 bits (242), Expect = 2e-20
Identities = 96/359 (26%), Positives = 156/359 (43%), Gaps = 46/359 (12%)
Query: 60 LYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLM-G 118
L ++ + ++GGN L+I+ + L ++L+ TN FL+SLAV+DLL+ + MP LL +
Sbjct: 60 LILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEA 119
Query: 119 TFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVAT 178
+ V+C A +L + + S + L AI+++RY AI +P+QA + +R+ A I
Sbjct: 120 MWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVV 179
Query: 179 WLLSGLLMVPYPVYTVVQPV-GPRVLQCVHRWPSARVRQTWSVLLL---LLLFFIPGVVM 234
WL+S + +P P+ + V P + CV ++ + +L L FF P +M
Sbjct: 180 WLISIGIAIPVPIKGIETDVDNPNNITCV------LTKERFGDFMLFGSLAAFFTPLAIM 233
Query: 235 AVAYGL----ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDS 290
V Y L + ++ YL ++ R V Q R ET +
Sbjct: 234 IVTYFLTIHALQKKAYL---------VKNKPPQRLTWLTVSTVFQ----RDETPCSSPEK 280
Query: 291 DGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKK---------RVVRMLLVIVVL 341
L SR L P G + + + KK R ++L ++ L
Sbjct: 281 ---VAMLDGSRKDKAL-----PNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFL 332
Query: 342 FFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQA 400
F L W P + N L F+ + Y S+ VNPLVY ++ FR A
Sbjct: 333 FLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFV-WIGYVSSGVNPLVYTLFNKTFRDA 390
>gi|157426873 tachykinin receptor 2 [Homo sapiens]
Length = 398
Score = 97.1 bits (240), Expect = 3e-20
Identities = 63/197 (31%), Positives = 104/197 (52%), Gaps = 6/197 (3%)
Query: 53 ELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTL 112
+LA+ T Y + L++V GN ++I ++ RR+RTVTN F+++LA++DL +A F
Sbjct: 32 QLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNF 91
Query: 113 LPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAA 172
+ + FG C + ++ VS S+ AIA +RY AI P Q R+ + A
Sbjct: 92 VYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKA- 150
Query: 173 RVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQT---WSVLLLLLLFFI 229
VI WL++ L P Y+ V + +CV WP +T + ++++ L++F+
Sbjct: 151 -VIAGIWLVALALASPQCFYSTV-TMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFL 208
Query: 230 PGVVMAVAYGLISRELY 246
P VM VAY +I L+
Sbjct: 209 PLAVMFVAYSVIGLTLW 225
Score = 47.4 bits (111), Expect = 3e-05
Identities = 25/87 (28%), Positives = 47/87 (54%), Gaps = 3/87 (3%)
Query: 325 LLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAF-DGPGAHRALSGAPISFIHLLSYASA 383
L A K+ V+ ++++V+ F +CWLP + +F + H+ + ++ + L+ +S
Sbjct: 242 LQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLA-LFWLAMSST 300
Query: 384 CVNPLVYCFMHRRFRQACLETCARCCP 410
NP++YC ++ RFR RCCP
Sbjct: 301 MYNPIIYCCLNHRFRSG-FRLAFRCCP 326
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.139 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,366,702
Number of Sequences: 37866
Number of extensions: 951811
Number of successful extensions: 6544
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 566
Number of HSP's successfully gapped in prelim test: 206
Number of HSP's that attempted gapping in prelim test: 4874
Number of HSP's gapped (non-prelim): 1215
length of query: 447
length of database: 18,247,518
effective HSP length: 105
effective length of query: 342
effective length of database: 14,271,588
effective search space: 4880883096
effective search space used: 4880883096
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.