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Search of human proteins with 28610147
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28610147 interleukin 6 signal transducer isoform 1 precursor
[Homo sapiens]
(918 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28610147 interleukin 6 signal transducer isoform 1 precursor ... 1888 0.0
gi|28610149 interleukin 6 signal transducer isoform 2 precursor ... 674 0.0
gi|115430248 gp130-like monocyte receptor [Homo sapiens] 255 1e-67
gi|4503081 colony stimulating factor 3 receptor isoform a precur... 249 1e-65
gi|27437045 colony stimulating factor 3 receptor isoform d precu... 245 1e-64
gi|24496783 colony stimulating factor 3 receptor isoform c precu... 241 2e-63
gi|27437042 colony stimulating factor 3 receptor isoform b precu... 215 2e-55
gi|4504993 leukemia inhibitory factor receptor precursor [Homo s... 187 4e-47
gi|189083786 leukemia inhibitory factor receptor precursor [Homo... 187 4e-47
gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens] 167 3e-41
gi|4557040 oncostatin M receptor [Homo sapiens] 135 1e-31
gi|4758062 cytokine receptor-like factor 1 [Homo sapiens] 122 2e-27
gi|51093381 leptin receptor isoform 3 [Homo sapiens] 103 7e-22
gi|51093379 leptin receptor isoform 2 [Homo sapiens] 103 7e-22
gi|40254464 leptin receptor isoform 1 [Homo sapiens] 103 7e-22
gi|4759328 class I cytokine receptor [Homo sapiens] 87 9e-17
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 80 9e-15
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 80 9e-15
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 80 9e-15
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 76 1e-13
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 76 1e-13
gi|222352127 sidekick 2 [Homo sapiens] 75 4e-13
gi|119220552 sidekick 1 [Homo sapiens] 74 6e-13
gi|24430212 interleukin 23 receptor precursor [Homo sapiens] 74 8e-13
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 74 8e-13
gi|4506107 prolactin receptor [Homo sapiens] 73 1e-12
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 73 1e-12
gi|22212918 ciliary neurotrophic factor receptor preproprotein [... 67 6e-11
gi|4502931 ciliary neurotrophic factor receptor preproprotein [H... 67 6e-11
gi|110349719 titin isoform N2-A [Homo sapiens] 62 3e-09
>gi|28610147 interleukin 6 signal transducer isoform 1 precursor
[Homo sapiens]
Length = 918
Score = 1888 bits (4891), Expect = 0.0
Identities = 918/918 (100%), Positives = 918/918 (100%)
Query: 1 MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV 60
MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV
Sbjct: 1 MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV 60
Query: 61 NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI 120
NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI
Sbjct: 61 NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI 120
Query: 121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT 180
ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT
Sbjct: 121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT 180
Query: 181 SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240
SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL
Sbjct: 181 SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240
Query: 241 KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR 300
KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR
Sbjct: 241 KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR 300
Query: 301 CMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEAN 360
CMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEAN
Sbjct: 301 CMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEAN 360
Query: 361 GKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACD 420
GKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACD
Sbjct: 361 GKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACD 420
Query: 421 FQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRT 480
FQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRT
Sbjct: 421 FQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRT 480
Query: 481 YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWD 540
YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWD
Sbjct: 481 YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWD 540
Query: 541 QLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGG 600
QLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGG
Sbjct: 541 QLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGG 600
Query: 601 KDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSK 660
KDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSK
Sbjct: 601 KDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSK 660
Query: 661 SHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKIN 720
SHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKIN
Sbjct: 661 SHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKIN 720
Query: 721 TEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRS 780
TEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRS
Sbjct: 721 TEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRS 780
Query: 781 ESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSV 840
ESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSV
Sbjct: 781 ESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSV 840
Query: 841 NEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEG 900
NEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEG
Sbjct: 841 NEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEG 900
Query: 901 MPKSYLPQTVRQGGYMPQ 918
MPKSYLPQTVRQGGYMPQ
Sbjct: 901 MPKSYLPQTVRQGGYMPQ 918
>gi|28610149 interleukin 6 signal transducer isoform 2 precursor
[Homo sapiens]
Length = 329
Score = 674 bits (1739), Expect = 0.0
Identities = 324/324 (100%), Positives = 324/324 (100%)
Query: 1 MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV 60
MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV
Sbjct: 1 MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV 60
Query: 61 NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI 120
NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI
Sbjct: 61 NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI 120
Query: 121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT 180
ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT
Sbjct: 121 ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT 180
Query: 181 SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240
SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL
Sbjct: 181 SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240
Query: 241 KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR 300
KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR
Sbjct: 241 KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR 300
Query: 301 CMKEDGKGYWSDWSEEASGITYED 324
CMKEDGKGYWSDWSEEASGITYED
Sbjct: 301 CMKEDGKGYWSDWSEEASGITYED 324
>gi|115430248 gp130-like monocyte receptor [Homo sapiens]
Length = 764
Score = 255 bits (652), Expect = 1e-67
Identities = 163/551 (29%), Positives = 268/551 (48%), Gaps = 14/551 (2%)
Query: 126 PEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWAT-HKFADCKAKRDTP---TS 181
P KP+N+SC+ K + C W G+ET T +T+K +A K +C T S
Sbjct: 54 PAKPENISCVYYYRKNLTCTWSPGKETSY-TQYTVKRTYAFGEKHDNCTTNSSTSENRAS 112
Query: 182 CTVDYSTVYFV-NIEVWVEAENALGKVTSDHINFDPVYKV-KPNPPHNLSVINSEELSSI 239
C+ + N + VEAEN G + S H+ + + + K PP V + +
Sbjct: 113 CSFFLPRITIPDNYTIEVEAENGDGVIKS-HMTYWRLENIAKTEPPKIFRVKPVLGIKRM 171
Query: 240 LKLTWTNPSIKSVII-LKYNIQYRTKDASTWSQIP-PEDTASTRSSFTVQDLKPFTEYVF 297
+++ W P + V LKY +++RT ++++W ++ ++ ++ + L+PFTEYV
Sbjct: 172 IQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTEYVI 231
Query: 298 RIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPF 357
+RC ++ K +WSDWS+E G+T E+ P W + P+ G R V+L+WK
Sbjct: 232 ALRCAVKESK-FWSDWSQEKMGMTEEEAPCGL-ELWRVLKPAEADGRRPVRLLWKKARGA 289
Query: 358 EANGKILDYEVTLTRWKSHLQNYTVNAT--KLTVNLTNDRYLATLTVRNLVGKSDAAVLT 415
K L Y + + T+N T +L ++L + + ++ N +GKS A L
Sbjct: 290 PVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKSPVATLR 349
Query: 416 IPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDG 475
IPA ++ + ++A ++ L V+W + V +++EW D P W+
Sbjct: 350 IPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEPTTLSWESVSQ 409
Query: 476 TVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEA 535
+ T + L CY I+V P+ D G P SI+AY K+ PS+GP + + +G
Sbjct: 410 ATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKVENIGVKTV 469
Query: 536 VLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAY 595
+ W ++P + G I NYTIFY+ G + V+SS +Y L SL T Y+V++ A
Sbjct: 470 TITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMAS 529
Query: 596 TDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNV 655
T GG +G F T F+ EI I + L+ +L V + K + + WP V
Sbjct: 530 TSAGGTNGTSINFKTLSFSVFEIILITSLIGGGLLILIILTVAYGLKKPNKLTHLCWPTV 589
Query: 656 PDPSKSHIAQW 666
P+P++S IA W
Sbjct: 590 PNPAESSIATW 600
>gi|4503081 colony stimulating factor 3 receptor isoform a precursor
[Homo sapiens]
Length = 836
Score = 249 bits (635), Expect = 1e-65
Identities = 227/813 (27%), Positives = 357/813 (43%), Gaps = 76/813 (9%)
Query: 6 TWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN-Y 64
TW AL I L S L+ CG+IS +P+V L TA C++K+ C H++
Sbjct: 10 TWA--ALIILLLPGS----LEECGHISVSAPIVHLGDPITASCIIKQNCS---HLDPEPQ 60
Query: 65 IVWKTNHFTIP--KEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS 122
I+W+ P ++Q S +T + L+C L +G Q + + + +
Sbjct: 61 ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSC-CLNWGNSLQILDQVELRA 119
Query: 123 GLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKS-------EWATHKFADCKA 174
G PP P NLSC++N + C+W+ G ETHL T+FTLKS + DC
Sbjct: 120 GYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVP 179
Query: 175 KRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234
K C + + N+ +WV+AENALG S + DP+ VK PP ++ S
Sbjct: 180 KDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSP 239
Query: 235 ELS----SILKLTWTNPSIKSVIILKYNIQYRT-KDASTWSQIPPEDTASTRSSFTVQDL 289
E + L+L W I K ++++ + ++W+ + P + + + + L
Sbjct: 240 EAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ--YELCGL 297
Query: 290 KPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK---IDPSHTQGYRT 346
P T Y +IRC++ G+WSDWS T E P+ W++ +DP RT
Sbjct: 298 LPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP------RT 351
Query: 347 VQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTV----NATKL--TVNLTNDRYLATL 400
VQL WK +P E +G+I Y V+ W+ Q + N T+L T +L ++ L
Sbjct: 352 VQLFWKPVPLEEDSGRIQGYVVS---WRPSGQAGAILPLCNTTELSCTFHLPSEAQEVAL 408
Query: 401 TVRNLVGKSDAAVLTIPACDFQATHPVMD-LKAFPKD-NMLWVEWTTPRESVKKYILEWC 458
N G S P ++ P + L A +D + LWV W P + Y++EW
Sbjct: 409 VAYNSAGTSRPT----PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG 464
Query: 459 VLSDKAPCITD-WQQE-DGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQ 516
+ A W+ E +G L+ N+ + Y I VTP+Y D G + + AY ++
Sbjct: 465 LGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQE 524
Query: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTE 576
PS P + K +GK A LEW P ++ + +YTIF+ + +++S
Sbjct: 525 MAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRG 584
Query: 577 YTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLG 636
+ L L +LY + + A + G + T T E+ I+ L LLT L G
Sbjct: 585 FVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCG 644
Query: 637 V--LFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVV 694
L C R K +WP+VPDP+ S + W P F Q+ G +
Sbjct: 645 TAWLCCSPNR---KNPLWPSVPDPAHSSLGSWVPTIMEEDAF----QLPGLGTPPITKLT 697
Query: 695 EIEANDKKPFPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPSISSSDENESSQNTS 754
+E ++KKP P +S + + + T + + G S++P +S TS
Sbjct: 698 VLEEDEKKPVP--WESHNSSETCGLPTLVQTYVLQGDPRAVSTQP--------QSQSGTS 747
Query: 755 STVQYSTVVHSGYRHQVPSVQVFSRSESTQPLL 787
V Y ++ S P + R +STQPLL
Sbjct: 748 DQVLYGQLLGS---PTSPGPGHYLRCDSTQPLL 777
>gi|27437045 colony stimulating factor 3 receptor isoform d
precursor [Homo sapiens]
Length = 783
Score = 245 bits (626), Expect = 1e-64
Identities = 208/731 (28%), Positives = 325/731 (44%), Gaps = 63/731 (8%)
Query: 6 TWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN-Y 64
TW AL I L S L+ CG+IS +P+V L TA C++K+ C H++
Sbjct: 10 TWA--ALIILLLPGS----LEECGHISVSAPIVHLGDPITASCIIKQNCS---HLDPEPQ 60
Query: 65 IVWKTNHFTIP--KEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS 122
I+W+ P ++Q S +T + L+C L +G Q + + + +
Sbjct: 61 ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSC-CLNWGNSLQILDQVELRA 119
Query: 123 GLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKS-------EWATHKFADCKA 174
G PP P NLSC++N + C+W+ G ETHL T+FTLKS + DC
Sbjct: 120 GYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVP 179
Query: 175 KRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234
K C + + N+ +WV+AENALG S + DP+ VK PP ++ S
Sbjct: 180 KDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSP 239
Query: 235 ELS----SILKLTWTNPSIKSVIILKYNIQYRT-KDASTWSQIPPEDTASTRSSFTVQDL 289
E + L+L W I K ++++ + ++W+ + P + + + + L
Sbjct: 240 EAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ--YELCGL 297
Query: 290 KPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK---IDPSHTQGYRT 346
P T Y +IRC++ G+WSDWS T E P+ W++ +DP RT
Sbjct: 298 LPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP------RT 351
Query: 347 VQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTV----NATKL--TVNLTNDRYLATL 400
VQL WK +P E +G+I Y V+ W+ Q + N T+L T +L ++ L
Sbjct: 352 VQLFWKPVPLEEDSGRIQGYVVS---WRPSGQAGAILPLCNTTELSCTFHLPSEAQEVAL 408
Query: 401 TVRNLVGKSDAAVLTIPACDFQATHPVMD-LKAFPKD-NMLWVEWTTPRESVKKYILEWC 458
N G S P ++ P + L A +D + LWV W P + Y++EW
Sbjct: 409 VAYNSAGTSRPT----PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG 464
Query: 459 VLSDKAPCITD-WQQE-DGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQ 516
+ A W+ E +G L+ N+ + Y I VTP+Y D G + + AY ++
Sbjct: 465 LGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQE 524
Query: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTE 576
PS P + K +GK A LEW P ++ + +YTIF+ + +++S
Sbjct: 525 MAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRG 584
Query: 577 YTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLG 636
+ L L +LY + + A + G + T T E+ I+ L LLT L G
Sbjct: 585 FVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCG 644
Query: 637 V--LFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVV 694
L C R K +WP+VPDP+ S + W P F Q+ G +
Sbjct: 645 TAWLCCSPNR---KNPLWPSVPDPAHSSLGSWVPTIMEEDAF----QLPGLGTPPITKLT 697
Query: 695 EIEANDKKPFP 705
+E ++KKP P
Sbjct: 698 VLEEDEKKPVP 708
>gi|24496783 colony stimulating factor 3 receptor isoform c
precursor [Homo sapiens]
Length = 863
Score = 241 bits (615), Expect = 2e-63
Identities = 200/694 (28%), Positives = 312/694 (44%), Gaps = 59/694 (8%)
Query: 6 TWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN-Y 64
TW AL I L S L+ CG+IS +P+V L TA C++K+ C H++
Sbjct: 10 TWA--ALIILLLPGS----LEECGHISVSAPIVHLGDPITASCIIKQNCS---HLDPEPQ 60
Query: 65 IVWKTNHFTIP--KEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS 122
I+W+ P ++Q S +T + L+C L +G Q + + + +
Sbjct: 61 ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSC-CLNWGNSLQILDQVELRA 119
Query: 123 GLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKS-------EWATHKFADCKA 174
G PP P NLSC++N + C+W+ G ETHL T+FTLKS + DC
Sbjct: 120 GYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVP 179
Query: 175 KRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234
K C + + N+ +WV+AENALG S + DP+ VK PP ++ S
Sbjct: 180 KDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSP 239
Query: 235 ELS----SILKLTWTNPSIKSVIILKYNIQYRT-KDASTWSQIPPEDTASTRSSFTVQDL 289
E + L+L W I K ++++ + ++W+ + P + + + + L
Sbjct: 240 EAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ--YELCGL 297
Query: 290 KPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK---IDPSHTQGYRT 346
P T Y +IRC++ G+WSDWS T E P+ W++ +DP RT
Sbjct: 298 LPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP------RT 351
Query: 347 VQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTV----NATKL--TVNLTNDRYLATL 400
VQL WK +P E +G+I Y V+ W+ Q + N T+L T +L ++ L
Sbjct: 352 VQLFWKPVPLEEDSGRIQGYVVS---WRPSGQAGAILPLCNTTELSCTFHLPSEAQEVAL 408
Query: 401 TVRNLVGKSDAAVLTIPACDFQATHPVMD-LKAFPKD-NMLWVEWTTPRESVKKYILEWC 458
N G S P ++ P + L A +D + LWV W P + Y++EW
Sbjct: 409 VAYNSAGTSRPT----PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG 464
Query: 459 VLSDKAPCITD-WQQE-DGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQ 516
+ A W+ E +G L+ N+ + Y I VTP+Y D G + + AY ++
Sbjct: 465 LGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQE 524
Query: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTE 576
PS P + K +GK A LEW P ++ + +YTIF+ + +++S
Sbjct: 525 MAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRG 584
Query: 577 YTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLG 636
+ L L +LY + + A + G + T T E+ I+ L LLT L G
Sbjct: 585 FVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCG 644
Query: 637 V--LFCFNKRDLIKKHIWPNVPDPSKSHIAQWSP 668
L C R K +WP+VPDP+ S + W P
Sbjct: 645 TAWLCCSPNR---KNPLWPSVPDPAHSSLGSWVP 675
>gi|27437042 colony stimulating factor 3 receptor isoform b
precursor [Homo sapiens]
Length = 769
Score = 215 bits (547), Expect = 2e-55
Identities = 179/634 (28%), Positives = 285/634 (44%), Gaps = 54/634 (8%)
Query: 6 TWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN-Y 64
TW AL I L S L+ CG+IS +P+V L TA C++K+ C H++
Sbjct: 10 TWA--ALIILLLPGS----LEECGHISVSAPIVHLGDPITASCIIKQNCS---HLDPEPQ 60
Query: 65 IVWKTNHFTIP--KEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS 122
I+W+ P ++Q S +T + L+C L +G Q + + + +
Sbjct: 61 ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSC-CLNWGNSLQILDQVELRA 119
Query: 123 GLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKS-------EWATHKFADCKA 174
G PP P NLSC++N + C+W+ G ETHL T+FTLKS + DC
Sbjct: 120 GYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVP 179
Query: 175 KRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234
K C + + N+ +WV+AENALG S + DP+ VK PP ++ S
Sbjct: 180 KDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSP 239
Query: 235 ELS----SILKLTWTNPSIKSVIILKYNIQYRT-KDASTWSQIPPEDTASTRSSFTVQDL 289
E + L+L W I K ++++ + ++W+ + P + + + + L
Sbjct: 240 EAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ--YELCGL 297
Query: 290 KPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK---IDPSHTQGYRT 346
P T Y +IRC++ G+WSDWS T E P+ W++ +DP RT
Sbjct: 298 LPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP------RT 351
Query: 347 VQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTV----NATKL--TVNLTNDRYLATL 400
VQL WK +P E +G+I Y V+ W+ Q + N T+L T +L ++ L
Sbjct: 352 VQLFWKPVPLEEDSGRIQGYVVS---WRPSGQAGAILPLCNTTELSCTFHLPSEAQEVAL 408
Query: 401 TVRNLVGKSDAAVLTIPACDFQATHPVMD-LKAFPKD-NMLWVEWTTPRESVKKYILEWC 458
N G S P ++ P + L A +D + LWV W P + Y++EW
Sbjct: 409 VAYNSAGTSRPT----PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG 464
Query: 459 VLSDKAPCITD-WQQE-DGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQ 516
+ A W+ E +G L+ N+ + Y I VTP+Y D G + + AY ++
Sbjct: 465 LGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQE 524
Query: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTE 576
PS P + K +GK A LEW P ++ + +YTIF+ + +++S
Sbjct: 525 MAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRG 584
Query: 577 YTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTT 610
+ L L +LY + + A + G + T T
Sbjct: 585 FVLHGLEPASLYHIHLMAASQAGATNSTVLTLMT 618
>gi|4504993 leukemia inhibitory factor receptor precursor [Homo
sapiens]
Length = 1097
Score = 187 bits (475), Expect = 4e-47
Identities = 166/667 (24%), Positives = 282/667 (42%), Gaps = 67/667 (10%)
Query: 31 ISPESPVVQLHSNFTAVCVLKEKCMDYF--HVNANYIVWKTNHFTIPKEQYTIINRTASS 88
+ P+ V+ + S+ T CV +EK + H N I + I ++ + ++
Sbjct: 254 VFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTN 313
Query: 89 VTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDG 148
V FT E N++G I +G PP+ P+ L+C ++ K++ C W+
Sbjct: 314 VVFTT------------------EDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNP 355
Query: 149 GRETHL----ETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVW---VEAE 201
GR T L T++TL + + K+ K + + PT+ + N E++ + A
Sbjct: 356 GRVTALVGPRATSYTLVESF-SGKYVRLK-RAEAPTNESYQLLFQMLPNQEIYNFTLNAH 413
Query: 202 NALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQY 261
N LG+ S I + KV P+ P + V + S+ +KL+W P + I I+
Sbjct: 414 NPLGRSQST-ILVNITEKVYPHTPTSFKV--KDINSTAVKLSWHLPGNFAKINFLCEIEI 470
Query: 262 RTKDASTWSQIPPEDTASTRSSFTV--QDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASG 319
+ K S Q SS+ V L P+T Y FRIRC E WS WS +
Sbjct: 471 K-KSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTET-FWKWSKWSNKKQH 528
Query: 320 ITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLT--RWKSHL 377
+T E PSK P W + + + + + WK LP EANGKIL Y V+ + L
Sbjct: 529 LTTEASPSKGPDTWRE----WSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSL 584
Query: 378 QNYTVNATKLTVNLTNDRYLATLTVRNLVGK---SDAAVLTIPACDFQATHPVMDLKAFP 434
K + L + Y+ ++ +N VG S A + IP D + V K
Sbjct: 585 SEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKG-- 642
Query: 435 KDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGN-LAESKCYL 493
+ + W Y+++WC S PC+ DW++ T + + Y
Sbjct: 643 ----ILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYN 698
Query: 494 ITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRN 553
+ G S+ Y+++ P P + + +++W+ +PV+ GF+R
Sbjct: 699 FFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRG 758
Query: 554 YTIFY----------RTIIGNETAVNV----DSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
Y ++ R + + + V D S ++ L T Y + + AYTD G
Sbjct: 759 YLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGG 818
Query: 600 GKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPS 659
T + + G I AI++PV +A ++ + +L C+ KR+ IK+ +P++P+P
Sbjct: 819 VGPEKSMYVVTKENSVGLIIAILIPVAVAVIVGVVTSIL-CYRKREWIKETFYPDIPNPE 877
Query: 660 KSHIAQW 666
Q+
Sbjct: 878 NCKALQF 884
>gi|189083786 leukemia inhibitory factor receptor precursor [Homo
sapiens]
Length = 1097
Score = 187 bits (475), Expect = 4e-47
Identities = 166/667 (24%), Positives = 282/667 (42%), Gaps = 67/667 (10%)
Query: 31 ISPESPVVQLHSNFTAVCVLKEKCMDYF--HVNANYIVWKTNHFTIPKEQYTIINRTASS 88
+ P+ V+ + S+ T CV +EK + H N I + I ++ + ++
Sbjct: 254 VFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTN 313
Query: 89 VTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDG 148
V FT E N++G I +G PP+ P+ L+C ++ K++ C W+
Sbjct: 314 VVFTT------------------EDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNP 355
Query: 149 GRETHL----ETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVW---VEAE 201
GR T L T++TL + + K+ K + + PT+ + N E++ + A
Sbjct: 356 GRVTALVGPRATSYTLVESF-SGKYVRLK-RAEAPTNESYQLLFQMLPNQEIYNFTLNAH 413
Query: 202 NALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQY 261
N LG+ S I + KV P+ P + V + S+ +KL+W P + I I+
Sbjct: 414 NPLGRSQST-ILVNITEKVYPHTPTSFKV--KDINSTAVKLSWHLPGNFAKINFLCEIEI 470
Query: 262 RTKDASTWSQIPPEDTASTRSSFTV--QDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASG 319
+ K S Q SS+ V L P+T Y FRIRC E WS WS +
Sbjct: 471 K-KSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTET-FWKWSKWSNKKQH 528
Query: 320 ITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLT--RWKSHL 377
+T E PSK P W + + + + + WK LP EANGKIL Y V+ + L
Sbjct: 529 LTTEASPSKGPDTWRE----WSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSL 584
Query: 378 QNYTVNATKLTVNLTNDRYLATLTVRNLVGK---SDAAVLTIPACDFQATHPVMDLKAFP 434
K + L + Y+ ++ +N VG S A + IP D + V K
Sbjct: 585 SEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKG-- 642
Query: 435 KDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGN-LAESKCYL 493
+ + W Y+++WC S PC+ DW++ T + + Y
Sbjct: 643 ----ILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYN 698
Query: 494 ITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRN 553
+ G S+ Y+++ P P + + +++W+ +PV+ GF+R
Sbjct: 699 FFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRG 758
Query: 554 YTIFY----------RTIIGNETAVNV----DSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
Y ++ R + + + V D S ++ L T Y + + AYTD G
Sbjct: 759 YLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGG 818
Query: 600 GKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPS 659
T + + G I AI++PV +A ++ + +L C+ KR+ IK+ +P++P+P
Sbjct: 819 VGPEKSMYVVTKENSVGLIIAILIPVAVAVIVGVVTSIL-CYRKREWIKETFYPDIPNPE 877
Query: 660 KSHIAQW 666
Q+
Sbjct: 878 NCKALQF 884
>gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens]
Length = 862
Score = 167 bits (424), Expect = 3e-41
Identities = 168/640 (26%), Positives = 264/640 (41%), Gaps = 63/640 (9%)
Query: 72 FTIPKEQYTIINRTASSVTFTDIASLNIQLT----------CNILTFGQLEQNVYGITII 121
F + I+ + + F SLN Q+T C + E + G I
Sbjct: 60 FHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIF 119
Query: 122 SGLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKR---- 176
G+ PE+P+NLSCI E + C W+ GR+THL T +TL+ + + K
Sbjct: 120 VGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCD 179
Query: 177 --DTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234
D + T + N V A N+LG +S F + V+P PP ++ + +
Sbjct: 180 YLDFGINLTPESPES---NFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQK 236
Query: 235 ELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTE 294
S L W + + +L ++YR ++ W+ + + + + DLKPFTE
Sbjct: 237 ASVSRCTLYWRDEGL----VLLNRLRYRPSNSRLWNMV---NVTKAKGRHDLLDLKPFTE 289
Query: 295 YVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWY---KIDPSHTQGYRTVQLVW 351
Y F+I KG WSDWSE T E+ P+ WY ID S Q + L W
Sbjct: 290 YEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQ----ISLFW 345
Query: 352 KTLPPFEANGKILDYEVT---LTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGK 408
K L EA GKIL Y+VT LT K+ QN T + + TV + ++ N G
Sbjct: 346 KNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGS 405
Query: 409 S-DAAVLTIPACDFQATHP-VMDLKAFPKDNMLWVEWTTPRE---SVKKYILEWCVL--S 461
S + + C+ P + + DN+L V W PR+ +V++Y++EW L
Sbjct: 406 SLPTRINIMNLCEAGLLAPRQVSANSEGMDNIL-VTWQPPRKDPSAVQEYVVEWRELHPG 464
Query: 462 DKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSK 521
+W + + N+ CY I V + D G SI K P
Sbjct: 465 GDTQVPLNWLRSRPYNVSALISENIKSYICYEIRVYALSGD-QGGCSSILGNSKHKAPLS 523
Query: 522 GPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNE----TAVNVDSSHTEY 577
GP + K ++ W+ +PV Q G + +Y I+++ N + S +
Sbjct: 524 GPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSH 583
Query: 578 TLSSLTSDTLYMVRMAAYTDEG-GKDGPEFTFTTPKFAQGEIE--AIVVP-VCLAFLLTT 633
++SL Y++ M A T G G E F QG+ A V P +C+A ++
Sbjct: 584 PINSLQPRVTYVLWMTALTAAGESSHGNEREFC----LQGKANWMAFVAPSICIAIIMVG 639
Query: 634 LLGVLFCFNKRDLIKKHIWP-----NVPDPSKSHIAQWSP 668
+ + K ++ + P +PDP+ S A+ P
Sbjct: 640 IFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTCAKKYP 679
>gi|4557040 oncostatin M receptor [Homo sapiens]
Length = 979
Score = 135 bits (341), Expect = 1e-31
Identities = 140/587 (23%), Positives = 232/587 (39%), Gaps = 56/587 (9%)
Query: 109 GQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHL------ETNFTLKS 162
G + + + GI + E+PK+ SC + K + C WD G +T L ++TL
Sbjct: 220 GNVSEGMKGIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFE 279
Query: 163 EWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKP 222
++ K C K T D Y + AEN L K S +I F+ ++V
Sbjct: 280 SFSGEKKL-CTHKNWCNWQITQDSQETY----NFTLIAENYLRK-RSVNILFNLTHRVYL 333
Query: 223 NPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRS 282
P +++ N ++I +TW SI++ I+ + + +
Sbjct: 334 MNPFSVNFENVNATNAI--MTWKVHSIRNNFTYLCQIELHGEGKMMQYNV----SIKVNG 387
Query: 283 SFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQ 342
+ + +L+P TEY+ R+RC WS+WS + + T E PS+AP W + S
Sbjct: 388 EYFLSELEPATEYMARVRCADASHFWKWSEWSGQ-NFTTLEAAPSEAPDVWRIV--SLEP 444
Query: 343 GYRTVQLVWKTLPPFEANGKILDYEVTLTRW----KSHLQNYTVNATKLTVNLTNDRYLA 398
G TV L WK L ANGKIL Y V + S L + A + L Y
Sbjct: 445 GNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPANSTKLILDRCSYQI 504
Query: 399 TLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWC 458
+ N VG S A+V+ I A V + + + + W V Y+++WC
Sbjct: 505 CVIANNSVGASPASVIVISA--DPENKEVEEERIAGTEGGFSLSWKPQPGDVIGYVVDWC 562
Query: 459 VLSDKAPCITDWQQEDGTVHRTYLR------GNLAESKCYLITVTPVYADGPGSPESIKA 512
+ W+ T + G + + Y ++ + E
Sbjct: 563 DHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIAC----LLEKKTG 618
Query: 513 YLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGN-----ETA 567
Y ++ PS P V + + L W + Q GFI+ Y ++ ++ E A
Sbjct: 619 YSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFEKA 678
Query: 568 VNVDSS-----------HTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQG 616
V D S + +L ++ Y + +T G +GP TFT
Sbjct: 679 VLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAG--EGPSATFTKVT-TPD 735
Query: 617 EIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHI 663
E ++++ + L + LL ++ C+ K IK+ +P++PDP KS I
Sbjct: 736 EHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKSSI 782
>gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]
Length = 422
Score = 122 bits (306), Expect = 2e-27
Identities = 85/302 (28%), Positives = 136/302 (45%), Gaps = 17/302 (5%)
Query: 31 ISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVT 90
ISP+ P + + S+ A C + D A + W N +P E ++N + ++
Sbjct: 43 ISPQDPTLLIGSSLLATCSVHG---DPPGATAEGLYWTLNGRRLPPELSRVLNASTLALA 99
Query: 91 FTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGR 150
++ + N++ + + G + GLPPEKP N+SC K + C W G
Sbjct: 100 LANLNGSRQRSGDNLVCHARDGSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPGA 159
Query: 151 --ETHLETNFTLKSEWATHKFADCKAKRDT--PTSCTVDYSTVYFVNIEVWVEAENALGK 206
ET L TN++LK + + + + T P SC + F E+WVEA N LG
Sbjct: 160 HGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEATNRLGS 219
Query: 207 VTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTN-PSIKSVII-LKYNIQYRTK 264
SD + D + V +PP ++ V L L + W + P++K + KY I+YR +
Sbjct: 220 ARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVE 279
Query: 265 DASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRC-----MKEDGKGYWSDWSEEASG 319
D+ W + D S ++S + LKP T Y ++RC G WS+WS +
Sbjct: 280 DSVDWKVV---DDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAA 336
Query: 320 IT 321
T
Sbjct: 337 ST 338
>gi|51093381 leptin receptor isoform 3 [Homo sapiens]
Length = 958
Score = 103 bits (257), Expect = 7e-22
Identities = 114/510 (22%), Positives = 202/510 (39%), Gaps = 47/510 (9%)
Query: 33 PESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFT-IPKEQYTIINRTASSVTF 91
P + + SN + C+ K++ V + IVW N IP+ QY +++ S VTF
Sbjct: 337 PPKILTSVGSNVSFHCIYKKENKI---VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTF 393
Query: 92 TDIA--------SLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMR 143
++ + + CN +Y I + + E L+ KM
Sbjct: 394 FNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLT-------KMT 446
Query: 144 CEWDGGR-----ETHLETNFTLKSEWAT-----HKFA---DCKAKRDTPTSCTVDYSTVY 190
C W E+ L+ + S + + H + DC + D C + ++
Sbjct: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECI--FQPIF 504
Query: 191 FVN-IEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249
++ +W+ ++LG + S P VKP PP ++ + + +LK++W P
Sbjct: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIG-LLKISWEKPVF 563
Query: 250 KSVIILKYNIQYRTKDAST-WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
L++ I+Y W D S S V DL Y ++RC + DG G
Sbjct: 564 PENN-LQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL--CAVYAVQVRCKRLDGLG 620
Query: 309 YWSDWSEEASGITYEDR-PSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYE 367
YWS+WS A + + + P + P FW I+ + + V L+WK L ++ + Y
Sbjct: 621 YWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYV 680
Query: 368 VT-LTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHP 426
+ T N TK T T + T+ N +G S A + +
Sbjct: 681 INHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNI 740
Query: 427 VMDLKAFP-KDNMLWVEWTTPRESVK--KYILEWCVLSDKAPCITDWQQEDGTVHRTYLR 483
V L A+P + + V W K +I+EW L++ W + +V + Y+
Sbjct: 741 VQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGE--IKWLRISSSVKKYYIH 798
Query: 484 GNLAESKCYLITVTPVYADGPGSPESIKAY 513
+ + Y ++ P++ +G G P+ I ++
Sbjct: 799 DHFIPIEKYQFSLYPIFMEGVGKPKIINSF 828
Score = 52.0 bits (123), Expect = 3e-06
Identities = 33/117 (28%), Positives = 61/117 (52%), Gaps = 15/117 (12%)
Query: 206 KVTSDHINFD-------PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYN 258
K+TS + F P+ VKP+PP L + +++ + LK++W++P + + +
Sbjct: 214 KITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--LKISWSSPPL-----VPFP 266
Query: 259 IQYRTKDASTWSQIPPE-DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314
+QY+ K + + + E D + +S V + P + Y ++R + DG G WSDWS
Sbjct: 267 LQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323
>gi|51093379 leptin receptor isoform 2 [Homo sapiens]
Length = 896
Score = 103 bits (257), Expect = 7e-22
Identities = 114/510 (22%), Positives = 202/510 (39%), Gaps = 47/510 (9%)
Query: 33 PESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFT-IPKEQYTIINRTASSVTF 91
P + + SN + C+ K++ V + IVW N IP+ QY +++ S VTF
Sbjct: 337 PPKILTSVGSNVSFHCIYKKENKI---VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTF 393
Query: 92 TDIA--------SLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMR 143
++ + + CN +Y I + + E L+ KM
Sbjct: 394 FNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLT-------KMT 446
Query: 144 CEWDGGR-----ETHLETNFTLKSEWAT-----HKFA---DCKAKRDTPTSCTVDYSTVY 190
C W E+ L+ + S + + H + DC + D C + ++
Sbjct: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECI--FQPIF 504
Query: 191 FVN-IEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249
++ +W+ ++LG + S P VKP PP ++ + + +LK++W P
Sbjct: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIG-LLKISWEKPVF 563
Query: 250 KSVIILKYNIQYRTKDAST-WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
L++ I+Y W D S S V DL Y ++RC + DG G
Sbjct: 564 PENN-LQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL--CAVYAVQVRCKRLDGLG 620
Query: 309 YWSDWSEEASGITYEDR-PSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYE 367
YWS+WS A + + + P + P FW I+ + + V L+WK L ++ + Y
Sbjct: 621 YWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYV 680
Query: 368 VT-LTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHP 426
+ T N TK T T + T+ N +G S A + +
Sbjct: 681 INHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNI 740
Query: 427 VMDLKAFP-KDNMLWVEWTTPRESVK--KYILEWCVLSDKAPCITDWQQEDGTVHRTYLR 483
V L A+P + + V W K +I+EW L++ W + +V + Y+
Sbjct: 741 VQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGE--IKWLRISSSVKKYYIH 798
Query: 484 GNLAESKCYLITVTPVYADGPGSPESIKAY 513
+ + Y ++ P++ +G G P+ I ++
Sbjct: 799 DHFIPIEKYQFSLYPIFMEGVGKPKIINSF 828
Score = 52.0 bits (123), Expect = 3e-06
Identities = 33/117 (28%), Positives = 61/117 (52%), Gaps = 15/117 (12%)
Query: 206 KVTSDHINFD-------PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYN 258
K+TS + F P+ VKP+PP L + +++ + LK++W++P + + +
Sbjct: 214 KITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--LKISWSSPPL-----VPFP 266
Query: 259 IQYRTKDASTWSQIPPE-DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314
+QY+ K + + + E D + +S V + P + Y ++R + DG G WSDWS
Sbjct: 267 LQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323
>gi|40254464 leptin receptor isoform 1 [Homo sapiens]
Length = 1165
Score = 103 bits (257), Expect = 7e-22
Identities = 114/510 (22%), Positives = 202/510 (39%), Gaps = 47/510 (9%)
Query: 33 PESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFT-IPKEQYTIINRTASSVTF 91
P + + SN + C+ K++ V + IVW N IP+ QY +++ S VTF
Sbjct: 337 PPKILTSVGSNVSFHCIYKKENKI---VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTF 393
Query: 92 TDIA--------SLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMR 143
++ + + CN +Y I + + E L+ KM
Sbjct: 394 FNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLT-------KMT 446
Query: 144 CEWDGGR-----ETHLETNFTLKSEWAT-----HKFA---DCKAKRDTPTSCTVDYSTVY 190
C W E+ L+ + S + + H + DC + D C + ++
Sbjct: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECI--FQPIF 504
Query: 191 FVN-IEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249
++ +W+ ++LG + S P VKP PP ++ + + +LK++W P
Sbjct: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIG-LLKISWEKPVF 563
Query: 250 KSVIILKYNIQYRTKDAST-WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
L++ I+Y W D S S V DL Y ++RC + DG G
Sbjct: 564 PENN-LQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL--CAVYAVQVRCKRLDGLG 620
Query: 309 YWSDWSEEASGITYEDR-PSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYE 367
YWS+WS A + + + P + P FW I+ + + V L+WK L ++ + Y
Sbjct: 621 YWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYV 680
Query: 368 VT-LTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHP 426
+ T N TK T T + T+ N +G S A + +
Sbjct: 681 INHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNI 740
Query: 427 VMDLKAFP-KDNMLWVEWTTPRESVK--KYILEWCVLSDKAPCITDWQQEDGTVHRTYLR 483
V L A+P + + V W K +I+EW L++ W + +V + Y+
Sbjct: 741 VQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGE--IKWLRISSSVKKYYIH 798
Query: 484 GNLAESKCYLITVTPVYADGPGSPESIKAY 513
+ + Y ++ P++ +G G P+ I ++
Sbjct: 799 DHFIPIEKYQFSLYPIFMEGVGKPKIINSF 828
Score = 52.0 bits (123), Expect = 3e-06
Identities = 33/117 (28%), Positives = 61/117 (52%), Gaps = 15/117 (12%)
Query: 206 KVTSDHINFD-------PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYN 258
K+TS + F P+ VKP+PP L + +++ + LK++W++P + + +
Sbjct: 214 KITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGN--LKISWSSPPL-----VPFP 266
Query: 259 IQYRTKDASTWSQIPPE-DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314
+QY+ K + + + E D + +S V + P + Y ++R + DG G WSDWS
Sbjct: 267 LQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323
>gi|4759328 class I cytokine receptor [Homo sapiens]
Length = 636
Score = 86.7 bits (213), Expect = 9e-17
Identities = 105/498 (21%), Positives = 180/498 (36%), Gaps = 34/498 (6%)
Query: 219 KVKPNPPH-NLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDT 277
++KPN P V SE+ + W P+ S +L YR + W+ + PE
Sbjct: 125 QMKPNAPRLGPDVDFSEDDPLEATVHWAPPTWPSHKVLICQFHYRRCQEAAWTLLEPELK 184
Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKID 337
+ +QDL+ T Y RC E + W +WS ++++ PS W +
Sbjct: 185 TIPLTPVEIQDLELATGYKVYGRCRMEKEEDLWGEWSPI---LSFQTPPSAPKDVWVSGN 241
Query: 338 PSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYL 397
T G L+WK A G + + W + T + +
Sbjct: 242 LCGTPGGEEPLLLWK------APGPCVQVSYKVWFWVGGRELSPEGITCCCSLIPSGAEW 295
Query: 398 ATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEW 457
A ++ N L++ D + + + + L V W +++++W
Sbjct: 296 ARVSAVNATSWEPLTNLSLVCLDSASAPRSVAVSSIAGSTELLVTWQPGPGEPLEHVVDW 355
Query: 458 CVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQA 517
D + +W + L GN Y ITVT V A G S S+ + ++
Sbjct: 356 ARDGDPLEKL-NWVRLPPGNLSALLPGNFTVGVPYRITVTAVSASGLASASSVWGFREEL 414
Query: 518 PPSKGPTV-RTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTE 576
P GPT+ R + + W ++P G + +YT+ ++ +NV +
Sbjct: 415 APLVGPTLWRLQDAPPGTPAIAWGEVPRHQLRGHLTHYTLCAQSGTSPSVCMNVSGNTQS 474
Query: 577 YTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLG 636
TL L + A+ G GP P + V+P L LLG
Sbjct: 475 VTLPDLPWGPCELWVTASTIAGQGPPGPILRLHLP---DNTLRWKVLPGILFLWGLFLLG 531
Query: 637 VLF-------CFNKR-DLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNF 688
C++ R ++ + +W VPDP+ S Q PH +Q+
Sbjct: 532 CGLSLATSGRCYHLRHKVLPRWVWEKVPDPANSSSGQ--PH---------MEQVPEAQPL 580
Query: 689 TDVSVVEIEANDKKPFPE 706
D+ ++E+E + P E
Sbjct: 581 GDLPILEVEEMEPPPVME 598
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 80.1 bits (196), Expect = 9e-15
Identities = 115/411 (27%), Positives = 180/411 (43%), Gaps = 56/411 (13%)
Query: 219 KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDAST-WSQIPPEDT 277
K P PP V +E ++ + LTW + + + V Y IQ++ K++ + +I +
Sbjct: 320 KALPKPPGTPVV--TESTATSITLTWDSGNPEPVSY--YIIQHKPKNSEELYKEI--DGV 373
Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKID 337
A+TR ++V L P+++Y FR+ + G+G SE T E PS AP
Sbjct: 374 ATTR--YSVAGLSPYSDYEFRVVAVNNIGRG---PPSEPVLTQTSEQAPSSAPRDVQARM 428
Query: 338 PSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKS-HLQNY---TVNATKLTV--NL 391
S T T+ + WK P E NG+I Y V T + H+ N+ V +++T NL
Sbjct: 429 LSST----TILVQWKE--PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 482
Query: 392 TNDR-----YLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPK-DNMLWVEWTT 445
+ LA ++ + SD V+T Q ++ KA P+ + + + WT
Sbjct: 483 VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP----LNFKAEPESETSILLSWTP 538
Query: 446 PR-ESVKKYILEWCVLSD----KAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVY 500
PR +++ Y L V D + IT E GT +R L+G L + Y +
Sbjct: 539 PRSDTIANYEL---VYKDGEHGEEQRITI---EPGTSYR--LQG-LKPNSLYYFRLAARS 589
Query: 501 ADGPG-SPESIKAYLKQAPPSKGPT-VRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY 558
G G S I A Q+ PS P + ++ W PV+ QNG I Y+I Y
Sbjct: 590 PQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 649
Query: 559 RTIIGNE----TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPE 605
+ G + + + S T+Y L L T Y + + A+TD G GPE
Sbjct: 650 TAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVG--PGPE 698
Score = 56.6 bits (135), Expect = 1e-07
Identities = 90/405 (22%), Positives = 146/405 (36%), Gaps = 45/405 (11%)
Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTR 281
P P N E S +L +WT P +S I Y + Y+ + +I T
Sbjct: 516 PGQPLNFKAEPESETSILL--SWTPP--RSDTIANYELVYKDGEHGEEQRI----TIEPG 567
Query: 282 SSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHT 341
+S+ +Q LKP + Y FR+ G G + E S T + +PS P PS T
Sbjct: 568 TSYRLQGLKPNSLYYFRLAARSPQGLGAST---AEISARTMQSKPSAPPQDISCTSPSST 624
Query: 342 QGYRTVQLVWKTLPPFEANGKILDYEVTLTRW-----KSH-LQNYTVNATKLTVNLTND- 394
++ + W+ P + NG I +Y + T K H + + TK +
Sbjct: 625 ----SILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKW 680
Query: 395 -RYLATLTVRNLVGKS--DAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTP----- 446
Y T+T VG +VL D + P + V W +P
Sbjct: 681 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 740
Query: 447 RESVKKYILEWC-----------VLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLIT 495
++ Y + + +L D W+ +D T H + G E+ Y +T
Sbjct: 741 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETS-YSLT 799
Query: 496 VTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYT 555
VT G G+ K P + N A+++W PVD G ++ Y
Sbjct: 800 VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHP-PVDT-FGPLQGYR 857
Query: 556 I-FYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
+ F R + T + +T + + Y+ R++A G
Sbjct: 858 LKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVG 902
Score = 43.9 bits (102), Expect = 7e-04
Identities = 91/416 (21%), Positives = 148/416 (35%), Gaps = 68/416 (16%)
Query: 237 SSILKLTWTNPSIKSVIILKYNIQYR---TKDASTWSQIPPEDTASTRSSFTVQDLKPFT 293
S+ + + W P + I Y + Y T+ + W + D+ T T+ +L P
Sbjct: 431 STTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT----TIGNLVPQK 486
Query: 294 EYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKT 353
Y ++ G G S + IT P + +F K +P + ++ L W
Sbjct: 487 TYSVKVLAFTSIGDG---PLSSDIQVITQTGVPGQPLNF--KAEP---ESETSILLSWT- 537
Query: 354 LPPFEANGKILDYEVTLTRWK-SHLQNYTVN---ATKLTVNLTNDRYLATLTVRNLVGK- 408
PP + I +YE+ + Q T+ + +L N Y L R+ G
Sbjct: 538 -PP--RSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLG 594
Query: 409 SDAAVLTIPACDFQATHPVMDLKAF-PKDNMLWVEWTTPR-ESVKKYILEWCVLSDKAPC 466
+ A ++ + + P D+ P + V W P E I E+ +
Sbjct: 595 ASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIK------ 648
Query: 467 ITDWQQEDGTVHRT---------YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLK-- 515
T ED H YL L + Y ITVT GPG PES+ ++
Sbjct: 649 YTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG-PESLSVLIRTN 707
Query: 516 ----QAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNV- 570
PP K V + V + W + Q+G IR Y + Y + E
Sbjct: 708 EDVPSGPPRK---VEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPM 764
Query: 571 --------------DSSHTEYTLSSLTSDTLYMVRMAAYT--DEGGKDGPEFTFTT 610
D++ + +S L +T Y + + AYT +G + P+ TT
Sbjct: 765 LKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 820
Score = 38.1 bits (87), Expect = 0.038
Identities = 32/109 (29%), Positives = 46/109 (42%), Gaps = 14/109 (12%)
Query: 507 PESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNET 566
PE + Q S+G T L W + +NG I YT+ YR I N
Sbjct: 914 PEEVPTGFPQNLHSEGTT-------STSVQLSWQPPVLAERNGIITKYTLLYRDI--NIP 964
Query: 567 AVNVDS----SHTEYTLSSLTSDTLYMVRMAAYTDEG-GKDGPEFTFTT 610
+ ++ + T TL+ L DT Y V++ A+T +G G P F T
Sbjct: 965 LLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1013
Score = 30.8 bits (68), Expect = 6.1
Identities = 24/80 (30%), Positives = 38/80 (47%), Gaps = 10/80 (12%)
Query: 237 SSILKLTWTNPSI--KSVIILKYNIQYRTKDASTWSQ---IPPEDTASTRSSFTVQDLKP 291
S+ ++L+W P + ++ II KY + YR + I P DT + T+ LKP
Sbjct: 932 STSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT-----TMTLTGLKP 986
Query: 292 FTEYVFRIRCMKEDGKGYWS 311
T Y ++R G G +S
Sbjct: 987 DTTYDVKVRAHTSKGPGPYS 1006
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform
2 precursor [Homo sapiens]
Length = 1899
Score = 80.1 bits (196), Expect = 9e-15
Identities = 115/411 (27%), Positives = 180/411 (43%), Gaps = 56/411 (13%)
Query: 219 KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDAST-WSQIPPEDT 277
K P PP V +E ++ + LTW + + + V Y IQ++ K++ + +I +
Sbjct: 307 KALPKPPGTPVV--TESTATSITLTWDSGNPEPVSY--YIIQHKPKNSEELYKEI--DGV 360
Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKID 337
A+TR ++V L P+++Y FR+ + G+G SE T E PS AP
Sbjct: 361 ATTR--YSVAGLSPYSDYEFRVVAVNNIGRG---PPSEPVLTQTSEQAPSSAPRDVQARM 415
Query: 338 PSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKS-HLQNY---TVNATKLTV--NL 391
S T T+ + WK P E NG+I Y V T + H+ N+ V +++T NL
Sbjct: 416 LSST----TILVQWKE--PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 469
Query: 392 TNDR-----YLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPK-DNMLWVEWTT 445
+ LA ++ + SD V+T Q ++ KA P+ + + + WT
Sbjct: 470 VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP----LNFKAEPESETSILLSWTP 525
Query: 446 PR-ESVKKYILEWCVLSD----KAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVY 500
PR +++ Y L V D + IT E GT +R L+G L + Y +
Sbjct: 526 PRSDTIANYEL---VYKDGEHGEEQRITI---EPGTSYR--LQG-LKPNSLYYFRLAARS 576
Query: 501 ADGPG-SPESIKAYLKQAPPSKGPT-VRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY 558
G G S I A Q+ PS P + ++ W PV+ QNG I Y+I Y
Sbjct: 577 PQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 636
Query: 559 RTIIGNE----TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPE 605
+ G + + + S T+Y L L T Y + + A+TD G GPE
Sbjct: 637 TAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVG--PGPE 685
Score = 56.6 bits (135), Expect = 1e-07
Identities = 90/405 (22%), Positives = 146/405 (36%), Gaps = 45/405 (11%)
Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTR 281
P P N E S +L +WT P +S I Y + Y+ + +I T
Sbjct: 503 PGQPLNFKAEPESETSILL--SWTPP--RSDTIANYELVYKDGEHGEEQRI----TIEPG 554
Query: 282 SSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHT 341
+S+ +Q LKP + Y FR+ G G + E S T + +PS P PS T
Sbjct: 555 TSYRLQGLKPNSLYYFRLAARSPQGLGAST---AEISARTMQSKPSAPPQDISCTSPSST 611
Query: 342 QGYRTVQLVWKTLPPFEANGKILDYEVTLTRW-----KSH-LQNYTVNATKLTVNLTND- 394
++ + W+ P + NG I +Y + T K H + + TK +
Sbjct: 612 ----SILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKW 667
Query: 395 -RYLATLTVRNLVGKS--DAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTP----- 446
Y T+T VG +VL D + P + V W +P
Sbjct: 668 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 727
Query: 447 RESVKKYILEWC-----------VLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLIT 495
++ Y + + +L D W+ +D T H + G E+ Y +T
Sbjct: 728 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETS-YSLT 786
Query: 496 VTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYT 555
VT G G+ K P + N A+++W PVD G ++ Y
Sbjct: 787 VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHP-PVDT-FGPLQGYR 844
Query: 556 I-FYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
+ F R + T + +T + + Y+ R++A G
Sbjct: 845 LKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVG 889
Score = 43.9 bits (102), Expect = 7e-04
Identities = 91/416 (21%), Positives = 148/416 (35%), Gaps = 68/416 (16%)
Query: 237 SSILKLTWTNPSIKSVIILKYNIQYR---TKDASTWSQIPPEDTASTRSSFTVQDLKPFT 293
S+ + + W P + I Y + Y T+ + W + D+ T T+ +L P
Sbjct: 418 STTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT----TIGNLVPQK 473
Query: 294 EYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKT 353
Y ++ G G S + IT P + +F K +P + ++ L W
Sbjct: 474 TYSVKVLAFTSIGDG---PLSSDIQVITQTGVPGQPLNF--KAEP---ESETSILLSWT- 524
Query: 354 LPPFEANGKILDYEVTLTRWK-SHLQNYTVN---ATKLTVNLTNDRYLATLTVRNLVGK- 408
PP + I +YE+ + Q T+ + +L N Y L R+ G
Sbjct: 525 -PP--RSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLG 581
Query: 409 SDAAVLTIPACDFQATHPVMDLKAF-PKDNMLWVEWTTPR-ESVKKYILEWCVLSDKAPC 466
+ A ++ + + P D+ P + V W P E I E+ +
Sbjct: 582 ASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIK------ 635
Query: 467 ITDWQQEDGTVHRT---------YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLK-- 515
T ED H YL L + Y ITVT GPG PES+ ++
Sbjct: 636 YTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG-PESLSVLIRTN 694
Query: 516 ----QAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNV- 570
PP K V + V + W + Q+G IR Y + Y + E
Sbjct: 695 EDVPSGPPRK---VEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPM 751
Query: 571 --------------DSSHTEYTLSSLTSDTLYMVRMAAYT--DEGGKDGPEFTFTT 610
D++ + +S L +T Y + + AYT +G + P+ TT
Sbjct: 752 LKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 807
Score = 38.1 bits (87), Expect = 0.038
Identities = 32/109 (29%), Positives = 46/109 (42%), Gaps = 14/109 (12%)
Query: 507 PESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNET 566
PE + Q S+G T L W + +NG I YT+ YR I N
Sbjct: 901 PEEVPTGFPQNLHSEGTT-------STSVQLSWQPPVLAERNGIITKYTLLYRDI--NIP 951
Query: 567 AVNVDS----SHTEYTLSSLTSDTLYMVRMAAYTDEG-GKDGPEFTFTT 610
+ ++ + T TL+ L DT Y V++ A+T +G G P F T
Sbjct: 952 LLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1000
Score = 30.8 bits (68), Expect = 6.1
Identities = 24/80 (30%), Positives = 38/80 (47%), Gaps = 10/80 (12%)
Query: 237 SSILKLTWTNPSI--KSVIILKYNIQYRTKDASTWSQ---IPPEDTASTRSSFTVQDLKP 291
S+ ++L+W P + ++ II KY + YR + I P DT + T+ LKP
Sbjct: 919 STSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADT-----TMTLTGLKP 973
Query: 292 FTEYVFRIRCMKEDGKGYWS 311
T Y ++R G G +S
Sbjct: 974 DTTYDVKVRAHTSKGPGPYS 993
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform
3 precursor [Homo sapiens]
Length = 1903
Score = 80.1 bits (196), Expect = 9e-15
Identities = 115/411 (27%), Positives = 180/411 (43%), Gaps = 56/411 (13%)
Query: 219 KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDAST-WSQIPPEDT 277
K P PP V +E ++ + LTW + + + V Y IQ++ K++ + +I +
Sbjct: 320 KALPKPPGTPVV--TESTATSITLTWDSGNPEPVSY--YIIQHKPKNSEELYKEI--DGV 373
Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKID 337
A+TR ++V L P+++Y FR+ + G+G SE T E PS AP
Sbjct: 374 ATTR--YSVAGLSPYSDYEFRVVAVNNIGRG---PPSEPVLTQTSEQAPSSAPRDVQARM 428
Query: 338 PSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKS-HLQNY---TVNATKLTV--NL 391
S T T+ + WK P E NG+I Y V T + H+ N+ V +++T NL
Sbjct: 429 LSST----TILVQWKE--PEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 482
Query: 392 TNDR-----YLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPK-DNMLWVEWTT 445
+ LA ++ + SD V+T Q ++ KA P+ + + + WT
Sbjct: 483 VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP----LNFKAEPESETSILLSWTP 538
Query: 446 PR-ESVKKYILEWCVLSD----KAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVY 500
PR +++ Y L V D + IT E GT +R L+G L + Y +
Sbjct: 539 PRSDTIANYEL---VYKDGEHGEEQRITI---EPGTSYR--LQG-LKPNSLYYFRLAARS 589
Query: 501 ADGPG-SPESIKAYLKQAPPSKGPT-VRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY 558
G G S I A Q+ PS P + ++ W PV+ QNG I Y+I Y
Sbjct: 590 PQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 649
Query: 559 RTIIGNE----TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPE 605
+ G + + + S T+Y L L T Y + + A+TD G GPE
Sbjct: 650 TAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVG--PGPE 698
Score = 48.1 bits (113), Expect = 4e-05
Identities = 89/415 (21%), Positives = 166/415 (40%), Gaps = 43/415 (10%)
Query: 221 KPN-PPHNLSVINSEELSSILKLTWTNPSIKSV--IILKYNIQYRTKDASTWSQIPPEDT 277
KP+ PP ++S S +SIL ++W P ++ II +Y+I+Y D
Sbjct: 608 KPSAPPQDISC-TSPSSTSIL-VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGI 665
Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGI--TYEDRPSKAPSFWYK 335
S + + ++ L+ +TEY + + G G E S + T ED PS P K
Sbjct: 666 PSDTTKYLLEQLEKWTEYRITVTAHTDVGPG-----PESLSVLIRTNEDVPSGPPR---K 717
Query: 336 IDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQN--------YTVNATKL 387
++ +V++ W++ P + +G+I Y+V R ++ +A +
Sbjct: 718 VEVEAVNS-TSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDM 776
Query: 388 TVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAF--PKDNMLWVEWTT 445
++ +LTV K D A P + N ++W
Sbjct: 777 IISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHP 836
Query: 446 PRES---VKKYILEWCVLSDKAPCIT-DWQQEDGTVHRTYLRGNLAESKCYLITVTPVYA 501
P ++ ++ Y L++ D P T ++ +++ T ++ + Y+ ++
Sbjct: 837 PVDTFGPLQGYRLKFG-RKDMEPLTTLEFSEKEDHFTAT----DIHKGASYVFRLSARNK 891
Query: 502 DGPGSPESIKAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRT 560
G G + + + P+ P + ++ L W + +NG I YT+ YR
Sbjct: 892 VGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 951
Query: 561 IIGNETAVNVDS----SHTEYTLSSLTSDTLYMVRMAAYTDEG-GKDGPEFTFTT 610
I N + ++ + T TL+ L DT Y V++ A+T +G G P F T
Sbjct: 952 I--NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1004
Score = 43.9 bits (102), Expect = 7e-04
Identities = 90/407 (22%), Positives = 147/407 (36%), Gaps = 59/407 (14%)
Query: 237 SSILKLTWTNPSIKSVIILKYNIQYR---TKDASTWSQIPPEDTASTRSSFTVQDLKPFT 293
S+ + + W P + I Y + Y T+ + W + D+ T T+ +L P
Sbjct: 431 STTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT----TIGNLVPQK 486
Query: 294 EYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKT 353
Y ++ G G S + IT P + +F K +P + ++ L W
Sbjct: 487 TYSVKVLAFTSIGDG---PLSSDIQVITQTGVPGQPLNF--KAEP---ESETSILLSWT- 537
Query: 354 LPPFEANGKILDYEVTLTRWK-SHLQNYTVN---ATKLTVNLTNDRYLATLTVRNLVGK- 408
PP + I +YE+ + Q T+ + +L N Y L R+ G
Sbjct: 538 -PP--RSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLG 594
Query: 409 SDAAVLTIPACDFQATHPVMDLKAF-PKDNMLWVEWTTPR-ESVKKYILEWCVLSDKAPC 466
+ A ++ + + P D+ P + V W P E I E+ +
Sbjct: 595 ASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIK------ 648
Query: 467 ITDWQQEDGTVHRT---------YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLK-- 515
T ED H YL L + Y ITVT GPG PES+ ++
Sbjct: 649 YTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG-PESLSVLIRTN 707
Query: 516 ----QAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVN-- 569
PP K V + V + W + Q+G IR Y + Y + E
Sbjct: 708 EDVPSGPPRK---VEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPM 764
Query: 570 ----VDSSHTEYTLSSLTSDTLYMVRMAAYT--DEGGKDGPEFTFTT 610
+ + + +S L +T Y + + AYT +G + P+ TT
Sbjct: 765 LKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 811
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform
1 precursor [Homo sapiens]
Length = 1907
Score = 76.3 bits (186), Expect = 1e-13
Identities = 109/411 (26%), Positives = 165/411 (40%), Gaps = 55/411 (13%)
Query: 219 KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTA 278
K P PP +L V +E ++ + LTW + + + V Y IQYR A T D
Sbjct: 316 KALPKPPIDLVV--TETTATSVTLTWDSGNSEPVTY--YGIQYRA--AGTEGPFQEVDGV 369
Query: 279 STRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDP 338
+T + +++ L PF+EY FR+ + G+G SE T E PS P +
Sbjct: 370 AT-TRYSIGGLSPFSEYAFRVLAVNSIGRG---PPSEAVRARTGEQAPSSPP----RRVQ 421
Query: 339 SHTQGYRTVQLVWKTLPPFEANGKILDYEVTLT--------RWKSHLQNYTVNAT--KLT 388
+ T+ + W+ PP E NG + Y V T W H + + T L
Sbjct: 422 ARMLSASTMLVQWE--PPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLL 479
Query: 389 VNLTND-RYLATLTVRNLVGKSDAAVLT---IPA--CDFQATHPVMDLKAFPKDNMLWVE 442
+T R LA V + V T +PA DFQA ++++ + + W+
Sbjct: 480 PGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQA-----EVESDTRIQLSWL- 533
Query: 443 WTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRT--YLRGNLAESKCYLITVTPVY 500
P+E + Y L + D+ QQ T T Y +L Y +
Sbjct: 534 -LPPQERIIMYELVYWAAEDED------QQHKVTFDPTSSYTLEDLKPDTLYRFQLAARS 586
Query: 501 ADGPG-SPESIKAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY 558
G G +I+A Q+ PS P V +G + W P D +NG I Y++ Y
Sbjct: 587 DMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAY 646
Query: 559 RTIIGNETAVNV----DSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPE 605
+ G + +V H+ + L L T Y V + A+TD G GPE
Sbjct: 647 EAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVG--PGPE 695
Score = 75.5 bits (184), Expect = 2e-13
Identities = 87/407 (21%), Positives = 167/407 (41%), Gaps = 51/407 (12%)
Query: 224 PPHNLSVINSEELSSILKLTWTNPSIKSV--IILKYNIQYRTKDASTWSQIPPEDTASTR 281
PP + ++ S+ ++++W P S +I +Y++ Y D + + +
Sbjct: 609 PPQKVMCVSMG--STTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREH 666
Query: 282 SSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGI---TYEDRPSKAPSFWYKIDP 338
SS+ + L+ +TEY +R + G G E+S + T ED PS P +++P
Sbjct: 667 SSWDLVGLEKWTEYRVWVRAHTDVGPG------PESSPVLVRTDEDVPSGPPRK-VEVEP 719
Query: 339 SHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTR---------------------WK-SH 376
++ V + WK P + +G+I Y+VT R W+
Sbjct: 720 LNSTA---VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEE 776
Query: 377 LQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKD 436
++Y + LT T +A T + +S ++T P M + +
Sbjct: 777 SEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGA--VPGRPTMMISTTAMN 834
Query: 437 NMLWVEWTTPRE---SVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYL 493
L ++W P+E + Y L++C + P D+ ++D + + L + Y+
Sbjct: 835 TAL-LQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDD----QHFTVTGLHKGTTYI 889
Query: 494 ITVTPVYADGPGSPESIKAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIR 552
+ G G + + PS P + + + L WD + +NG I
Sbjct: 890 FRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRII 949
Query: 553 NYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
+YT+ +R I + N+ ++ T +TL+ L DT Y +++ A+T +G
Sbjct: 950 SYTVVFRDINSQQELQNI-TTDTRFTLTGLKPDTTYDIKVRAWTSKG 995
Score = 52.0 bits (123), Expect = 3e-06
Identities = 83/411 (20%), Positives = 149/411 (36%), Gaps = 54/411 (13%)
Query: 235 ELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTE 294
E + ++L+W P + +I+ + + + +D ++ + T SS+T++DLKP T
Sbjct: 523 ESDTRIQLSWLLPPQERIIMYEL-VYWAAEDEDQQHKVTFDPT----SSYTLEDLKPDTL 577
Query: 295 YVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTL 354
Y F++ + G G ++ E T + PS P + + G TV++ W
Sbjct: 578 YRFQLAARSDMGVGVFTPTIEAR---TAQSTPSAPPQKVMCV----SMGSTTVRVSWVPP 630
Query: 355 PPFEANGKILDYEVTLTRW--------------KSHLQNYTVNATKLTVNLTNDRYLATL 400
P NG I Y V + H V K T Y +
Sbjct: 631 PADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWT------EYRVWV 684
Query: 401 TVRNLVGKS-DAAVLTIPACDFQATHPVMDLKAFPKDNM-LWVEWTTPRES-----VKKY 453
VG +++ + + + + P ++ P ++ + V W P S ++ Y
Sbjct: 685 RAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGY 744
Query: 454 ILEWCVLSDKAP-----------CITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYAD 502
+ + L + P W+ E+ + T + G L Y +TV
Sbjct: 745 QVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISG-LTPETTYSVTVAAYTTK 803
Query: 503 GPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY-RTI 561
G G+ K PT+ N A+L+W P G + Y + Y R
Sbjct: 804 GDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWH--PPKELPGELLGYRLQYCRAD 861
Query: 562 IGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPK 612
++ +T++ L T Y+ R+AA G + E TP+
Sbjct: 862 EARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPE 912
Score = 41.2 bits (95), Expect = 0.004
Identities = 97/412 (23%), Positives = 152/412 (36%), Gaps = 59/412 (14%)
Query: 237 SSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYV 296
+S + + W P + ++ Y + Y T D+ + TV L P Y
Sbjct: 427 ASTMLVQWEPPEEPNGLVRGYRVYY-TPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYS 485
Query: 297 FRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPP 356
R+ G G S + T + P++ F +++ S T+ +QL W LPP
Sbjct: 486 LRVLAFTAVGDGPPSPTIQVK---TQQGVPAQPADFQAEVE-SDTR----IQLSW-LLPP 536
Query: 357 FEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAV--- 413
E +I+ YE+ + Q + V + D TL L +SD V
Sbjct: 537 QE---RIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVF 593
Query: 414 -LTIPACDFQATHPVMDLKAF---PKDNMLWVEWTTP-RESVKKYILEWCVL------SD 462
TI A Q+T K + V W P +S I ++ V D
Sbjct: 594 TPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGED 653
Query: 463 KAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLK------Q 516
+ + D + H ++ L + Y + V GPG PES ++
Sbjct: 654 RGRHVVDGISRE---HSSWDLVGLEKWTEYRVWVRAHTDVGPG-PESSPVLVRTDEDVPS 709
Query: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPV-DVQNGFIRNYTIFY-RTIIGNETAVNV---- 570
PP K V + + + W +LPV Q+G IR Y + Y R G + +
Sbjct: 710 GPPRK---VEVEPLNSTAVHVYW-KLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDV 765
Query: 571 ----------DSSHTEYTLSSLTSDTLYMVRMAAYT--DEGGKDGPEFTFTT 610
+S E T+S LT +T Y V +AAYT +G + P+ TT
Sbjct: 766 MLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTT 817
Score = 30.4 bits (67), Expect = 7.9
Identities = 23/86 (26%), Positives = 40/86 (46%), Gaps = 9/86 (10%)
Query: 225 PHNLSVINSEELSSILKLTWTNPSI--KSVIILKYNIQYRTKDASTWSQIPPEDTASTRS 282
P NL V +S +L W P + ++ I+ Y + +R D ++ ++ +T +
Sbjct: 919 PQNLHVTGLT--TSTTELAWDPPVLAERNGRIISYTVVFR--DINSQQEL---QNITTDT 971
Query: 283 SFTVQDLKPFTEYVFRIRCMKEDGKG 308
FT+ LKP T Y ++R G G
Sbjct: 972 RFTLTGLKPDTTYDIKVRAWTSKGSG 997
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform
2 precursor [Homo sapiens]
Length = 1898
Score = 76.3 bits (186), Expect = 1e-13
Identities = 109/411 (26%), Positives = 165/411 (40%), Gaps = 55/411 (13%)
Query: 219 KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTA 278
K P PP +L V +E ++ + LTW + + + V Y IQYR A T D
Sbjct: 316 KALPKPPIDLVV--TETTATSVTLTWDSGNSEPVTY--YGIQYRA--AGTEGPFQEVDGV 369
Query: 279 STRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDP 338
+T + +++ L PF+EY FR+ + G+G SE T E PS P +
Sbjct: 370 AT-TRYSIGGLSPFSEYAFRVLAVNSIGRG---PPSEAVRARTGEQAPSSPP----RRVQ 421
Query: 339 SHTQGYRTVQLVWKTLPPFEANGKILDYEVTLT--------RWKSHLQNYTVNAT--KLT 388
+ T+ + W+ PP E NG + Y V T W H + + T L
Sbjct: 422 ARMLSASTMLVQWE--PPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLL 479
Query: 389 VNLTND-RYLATLTVRNLVGKSDAAVLT---IPA--CDFQATHPVMDLKAFPKDNMLWVE 442
+T R LA V + V T +PA DFQA ++++ + + W+
Sbjct: 480 PGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQA-----EVESDTRIQLSWL- 533
Query: 443 WTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRT--YLRGNLAESKCYLITVTPVY 500
P+E + Y L + D+ QQ T T Y +L Y +
Sbjct: 534 -LPPQERIIMYELVYWAAEDED------QQHKVTFDPTSSYTLEDLKPDTLYRFQLAARS 586
Query: 501 ADGPG-SPESIKAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY 558
G G +I+A Q+ PS P V +G + W P D +NG I Y++ Y
Sbjct: 587 DMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAY 646
Query: 559 RTIIGNETAVNV----DSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPE 605
+ G + +V H+ + L L T Y V + A+TD G GPE
Sbjct: 647 EAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVG--PGPE 695
Score = 74.7 bits (182), Expect = 4e-13
Identities = 87/400 (21%), Positives = 167/400 (41%), Gaps = 46/400 (11%)
Query: 224 PPHNLSVINSEELSSILKLTWTNPSIKSV--IILKYNIQYRTKDASTWSQIPPEDTASTR 281
PP + ++ S+ ++++W P S +I +Y++ Y D + + +
Sbjct: 609 PPQKVMCVSMG--STTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREH 666
Query: 282 SSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGI---TYEDRPSKAPSFWYKIDP 338
SS+ + L+ +TEY +R + G G E+S + T ED PS P +++P
Sbjct: 667 SSWDLVGLEKWTEYRVWVRAHTDVGPG------PESSPVLVRTDEDVPSGPPRK-VEVEP 719
Query: 339 SHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKS---------------HLQNYTVN 383
++ V + WK P + +G+I Y+VT R ++ Q T++
Sbjct: 720 LNSTA---VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTIS 776
Query: 384 ATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEW 443
LT T +A T + +S ++T P M + + L ++W
Sbjct: 777 G--LTPETTYSVTVAAYTTKGDGARSKPKIVTTTGA--VPGRPTMMISTTAMNTAL-LQW 831
Query: 444 TTPRE---SVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVY 500
P+E + Y L++C + P D+ ++D + + L + Y+ +
Sbjct: 832 HPPKELPGELLGYRLQYCRADEARPNTIDFGKDD----QHFTVTGLHKGTTYIFRLAAKN 887
Query: 501 ADGPGSPESIKAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYR 559
G G + + PS P + + + L WD + +NG I +YT+ +R
Sbjct: 888 RAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR 947
Query: 560 TIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
I + N+ ++ T +TL+ L DT Y +++ A+T +G
Sbjct: 948 DINSQQELQNI-TTDTRFTLTGLKPDTTYDIKVRAWTSKG 986
Score = 46.2 bits (108), Expect = 1e-04
Identities = 83/404 (20%), Positives = 147/404 (36%), Gaps = 49/404 (12%)
Query: 235 ELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTE 294
E + ++L+W P + +I+ + + + +D ++ + T SS+T++DLKP T
Sbjct: 523 ESDTRIQLSWLLPPQERIIMYEL-VYWAAEDEDQQHKVTFDPT----SSYTLEDLKPDTL 577
Query: 295 YVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTL 354
Y F++ + G G ++ E T + PS P + + G TV++ W
Sbjct: 578 YRFQLAARSDMGVGVFTPTIEAR---TAQSTPSAPPQKVMCV----SMGSTTVRVSWVPP 630
Query: 355 PPFEANGKILDYEVTLTRW--------------KSHLQNYTVNATKLTVNLTNDRYLATL 400
P NG I Y V + H V K T Y +
Sbjct: 631 PADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWT------EYRVWV 684
Query: 401 TVRNLVGKS-DAAVLTIPACDFQATHPVMDLKAFPKDNM-LWVEWTTPRES-----VKKY 453
VG +++ + + + + P ++ P ++ + V W P S ++ Y
Sbjct: 685 RAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGY 744
Query: 454 ILEWCVLSDKAP----CITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPES 509
+ + L + P I D + T + G L Y +TV G G+
Sbjct: 745 QVTYVRLENGEPRGLPIIQDVMLAEA--QETTISG-LTPETTYSVTVAAYTTKGDGARSK 801
Query: 510 IKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY-RTIIGNETAV 568
K PT+ N A+L+W P G + Y + Y R +
Sbjct: 802 PKIVTTTGAVPGRPTMMISTTAMNTALLQWH--PPKELPGELLGYRLQYCRADEARPNTI 859
Query: 569 NVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPK 612
+ +T++ L T Y+ R+AA G + E TP+
Sbjct: 860 DFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPE 903
Score = 42.0 bits (97), Expect = 0.003
Identities = 96/403 (23%), Positives = 151/403 (37%), Gaps = 50/403 (12%)
Query: 237 SSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYV 296
+S + + W P + ++ Y + Y T D+ + TV L P Y
Sbjct: 427 ASTMLVQWEPPEEPNGLVRGYRVYY-TPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYS 485
Query: 297 FRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPP 356
R+ G G S + T + P++ F +++ S T+ +QL W LPP
Sbjct: 486 LRVLAFTAVGDGPPSPTIQVK---TQQGVPAQPADFQAEVE-SDTR----IQLSW-LLPP 536
Query: 357 FEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAV--- 413
E +I+ YE+ + Q + V + D TL L +SD V
Sbjct: 537 QE---RIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVF 593
Query: 414 -LTIPACDFQATHPVMDLKAF---PKDNMLWVEWTTP-RESVKKYILEWCVL------SD 462
TI A Q+T K + V W P +S I ++ V D
Sbjct: 594 TPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGED 653
Query: 463 KAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLK------Q 516
+ + D + H ++ L + Y + V GPG PES ++
Sbjct: 654 RGRHVVDGISRE---HSSWDLVGLEKWTEYRVWVRAHTDVGPG-PESSPVLVRTDEDVPS 709
Query: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPV-DVQNGFIRNYTIFYRTIIGNETA---VNVD- 571
PP K V + + + W +LPV Q+G IR Y + Y + E + D
Sbjct: 710 GPPRK---VEVEPLNSTAVHVYW-KLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDV 765
Query: 572 --SSHTEYTLSSLTSDTLYMVRMAAYT--DEGGKDGPEFTFTT 610
+ E T+S LT +T Y V +AAYT +G + P+ TT
Sbjct: 766 MLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTT 808
Score = 30.4 bits (67), Expect = 7.9
Identities = 23/86 (26%), Positives = 40/86 (46%), Gaps = 9/86 (10%)
Query: 225 PHNLSVINSEELSSILKLTWTNPSI--KSVIILKYNIQYRTKDASTWSQIPPEDTASTRS 282
P NL V +S +L W P + ++ I+ Y + +R D ++ ++ +T +
Sbjct: 910 PQNLHVTGLT--TSTTELAWDPPVLAERNGRIISYTVVFR--DINSQQEL---QNITTDT 962
Query: 283 SFTVQDLKPFTEYVFRIRCMKEDGKG 308
FT+ LKP T Y ++R G G
Sbjct: 963 RFTLTGLKPDTTYDIKVRAWTSKGSG 988
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 74.7 bits (182), Expect = 4e-13
Identities = 134/595 (22%), Positives = 219/595 (36%), Gaps = 92/595 (15%)
Query: 104 NILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWD-------GGRETHLET 156
N + G Q V G T S +P P N+S + M W G +
Sbjct: 1179 NAIGSGPWSQTVVGRTRES-VPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKV 1237
Query: 157 NFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINF-D 215
+ K +F + T +V EV V A +G + H +
Sbjct: 1238 MYKEKDSDTQPRFWLVEGNSSRSAQLT---GLGKYVLYEVQVLAFTRIGDGSPSHPPILE 1294
Query: 216 PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPE 275
P PP + ++ E ++ ++L W P+ + IIL Y I +R + +T + E
Sbjct: 1295 RTLDDVPGPP--MGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRL-NTTTANTATVE 1351
Query: 276 DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK 335
A + +T LKP + Y+FRI G W + + EA +T E R P
Sbjct: 1352 VLAPSARQYTATGLKPESVYLFRITAQTRKG---WGE-AAEALVVTTEKRDRPQPPSRPM 1407
Query: 336 IDPSHTQGYRTVQLVWKTLPPFEANGKILDY-----EVTLTRWKSHLQNYTVNATKLTVN 390
+ + R+V L W+ P + + Y E+ RW H + + NA+ V+
Sbjct: 1408 VQQEDVRA-RSVLLSWE--PGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVD 1464
Query: 391 LTND--RYLATLTVRNLVGKSD-----AAVLTIPACDFQATHPVMDLKAFPKDNMLWVEW 443
Y + N +G S+ ++ T+ A +A ++ + ++L + W
Sbjct: 1465 RLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAP-TILSVTPHTTTSVL-IRW 1522
Query: 444 TTPRESVKKYIL----------------------------EWCVLSD-------KAPCIT 468
P E IL W L+ P +T
Sbjct: 1523 QPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLT 1582
Query: 469 DWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGP-TVRT 527
++ ++ HR Y ++V +GP SP + ++ +A P+ P V
Sbjct: 1583 QYELDNLNKHRRYE---------IRMSVYNAVGEGPSSPPQ-EVFVGEAVPTAAPRNVVV 1632
Query: 528 KKVGKNEAVLEWDQLPVDVQNGFIRNYTI-FYRTIIGN--ETAVNVDSSHTEYTLSSLTS 584
+ + W+ P+D QNG I+ Y I F+ GN E + + L +LT
Sbjct: 1633 HGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTG 1692
Query: 585 DTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAF--LLTTLLGV 637
T YMV +AA+ G DGP +TP Q + A P + F L TT + V
Sbjct: 1693 YTAYMVSVAAFNAAG--DGPR---STPTQGQTQQAAPSAPSSVKFSELTTTSVNV 1742
Score = 45.1 bits (105), Expect = 3e-04
Identities = 118/529 (22%), Positives = 193/529 (36%), Gaps = 58/529 (10%)
Query: 109 GQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHK 168
GQ ++ +++ P P+N+ + + +W E+H N LK +
Sbjct: 674 GQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESH--QNGILKGYIIRYC 731
Query: 169 FADC------KAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGK-VTSDHINFDPVYKVK 221
A K D + + + + N E+ V A N+ G V S + + V
Sbjct: 732 LAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVP 791
Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSV--IILKYNI---QYRTKDASTWSQIPPED 276
PP N+ + S+ ++ TW PS + + I Y + + ++ T P
Sbjct: 792 TVPPGNVHAEATN--STTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNF 849
Query: 277 TASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAP--SFWY 334
S F V LK FTEY + C G G S T+ED P SF
Sbjct: 850 QDSIHVGF-VSGLKKFTEYFTSVLCFTTPGDG---PRSTPQLVRTHEDVPGPVGHLSFSE 905
Query: 335 KIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEV-------TLTRWKSHLQNYTV--NAT 385
+D S +++ W+ P E NG + Y + T TR +L N T+ T
Sbjct: 906 ILDTS-------LKVSWQ--EPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVT 956
Query: 386 KLTVNLTNDRYLATLTVRNLVGKSDAAVLTI-----PACDFQATHPVMDLKAFPKDNMLW 440
LT T +A +T + G+ + TI P T+ + + +
Sbjct: 957 GLTALTTYTIEVAAMTSK---GQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQF 1013
Query: 441 VEWTTPRESVKKYILE--WCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTP 498
+ S+ ++++E V+ + + Q + R+ +L CY +
Sbjct: 1014 RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQ 1073
Query: 499 VYADG--PGSPESIKAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRN-- 553
V G P S S K QAPP P V + + L W LP NG +
Sbjct: 1074 VNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVG 1133
Query: 554 YTIFYRTIIGNETAVN---VDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
Y I Y G+ ++ D +YT+ L T Y V++ A+ G
Sbjct: 1134 YKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG 1182
Score = 45.1 bits (105), Expect = 3e-04
Identities = 99/465 (21%), Positives = 168/465 (36%), Gaps = 72/465 (15%)
Query: 196 VWVEAENALGKVT-SDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVII 254
V V+A NA+G S + V + P N+S + + S +++ + + ++ ++
Sbjct: 1173 VQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLV 1232
Query: 255 LKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWS 314
L Y + Y+ KD+ T + + S+RS+ + L + Y ++ G G S
Sbjct: 1233 LGYKVMYKEKDSDTQPRFWLVEGNSSRSA-QLTGLGKYVLYEVQVLAFTRIGDG--SPSH 1289
Query: 315 EEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWK 374
T +D P P T +V+L+W+ PP NG IL Y++T
Sbjct: 1290 PPILERTLDDVP--GPPMGILFPEVRT---TSVRLIWQ--PPAAPNGIILAYQIT----- 1337
Query: 375 SHLQNYTVNATKLTVNLTNDR------------YLATLTVRNLVGKSDAAVLTIPACDFQ 422
L T N + V + R YL +T + G +AA + + +
Sbjct: 1338 HRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKR 1397
Query: 423 -----ATHPVMDLKAFPKDNML--WVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDG 475
+ P++ + ++L W + V+ Y ++ L W
Sbjct: 1398 DRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGR-----WALHSA 1452
Query: 476 TVHR---TYLRGNLAESKCYLITV--TPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKV 530
+V +++ L Y V T D S ES QA P + PT+ +
Sbjct: 1453 SVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTP 1512
Query: 531 GKNEAVL-EWDQLPVDVQNGFIRNYTIFYRTI------------IGNETAVNVD------ 571
+VL W D NG + + I YR + I N A +
Sbjct: 1513 HTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYS 1572
Query: 572 ------SSHTEYTLSSLTSDTLYMVRMAAY--TDEGGKDGPEFTF 608
S T+Y L +L Y +RM+ Y EG P+ F
Sbjct: 1573 MRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVF 1617
Score = 43.9 bits (102), Expect = 7e-04
Identities = 99/435 (22%), Positives = 162/435 (37%), Gaps = 63/435 (14%)
Query: 225 PHNLSVINSEELSSILKLTWT-------NPSIKSVIILKYNIQYRTKDA--STWSQIPPE 275
P N+S+ + E S L L W N + +SV Y I+Y D T S + +
Sbjct: 1100 PANVSLRTASETS--LWLRWMPLPEMEYNGNPESV---GYKIKYSRSDGHGKTLSHVVQD 1154
Query: 276 DTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK 335
+T++DL+ +TEY +++ G G WS+ G T E PS P+
Sbjct: 1155 ---RVERDYTIEDLEEWTEYRVQVQAFNAIGSG---PWSQTVVGRTRESVPSSGPTNVSA 1208
Query: 336 IDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDR 395
+ + + ++ + W +P + NG +L Y+V S Q + + N
Sbjct: 1209 LATTSS----SMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQ------PRFWLVEGNSS 1258
Query: 396 YLATLTVRNLVGKSDAAVLTIPAC-DFQATHP-----VMDLKAFPKDNMLWVEWTT---- 445
A LT + VL D +HP +D P +L+ E T
Sbjct: 1259 RSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVR 1318
Query: 446 ----PRESVKKYILEWCVLS--DKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPV 499
P + IL + + + T + R Y L YL +T
Sbjct: 1319 LIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQ 1378
Query: 500 YADGPGSPESIKAYL-------KQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIR 552
G G E+ +A + + PPS+ P V+ + V +L W+ P +R
Sbjct: 1379 TRKGWG--EAAEALVVTTEKRDRPQPPSR-PMVQQEDVRARSVLLSWE--PGSDGLSPVR 1433
Query: 553 NYTIFYRTIIGNETAV---NVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPE--FT 607
YTI R + A+ +V + + + + L T Y R+ A D G + E +
Sbjct: 1434 YYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESES 1493
Query: 608 FTTPKFAQGEIEAIV 622
TT + A E I+
Sbjct: 1494 LTTLQAAPDEAPTIL 1508
Score = 43.5 bits (101), Expect = 0.001
Identities = 35/143 (24%), Positives = 66/143 (46%), Gaps = 9/143 (6%)
Query: 224 PPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSS 283
P H ++ +++ E +I LTWT P + +++Y ++ +A + D +T S
Sbjct: 593 PEHPVATLSTVERRAI-NLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKAT--S 649
Query: 284 FTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQG 343
TV+ L P Y FR+ + + GKG +S++ ++ + P AP I T
Sbjct: 650 VTVKGLVPARSYQFRLCAVNDVGKG---QFSKDTERVSLPEEPPTAPP-QNVIASGRTN- 704
Query: 344 YRTVQLVWKTLPPFEANGKILDY 366
+++ + W+ P NG + Y
Sbjct: 705 -QSIMIQWQPPPESHQNGILKGY 726
Score = 40.8 bits (94), Expect = 0.006
Identities = 46/199 (23%), Positives = 77/199 (38%), Gaps = 11/199 (5%)
Query: 409 SDAAVLTIPACDFQATHPVMDLKAFPKD--NMLWVEWTTPRESVKKYILEWCVLSDKAPC 466
S +A L + HPV L + N+ W + + +YILE + + AP
Sbjct: 579 SRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILE--MSENNAPW 636
Query: 467 ITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPG--SPESIKAYLKQAPPSKGPT 524
D ++G L ++ Y + V G G S ++ + L + PP+ P
Sbjct: 637 TVLLASVDPKATSVTVKG-LVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQ 695
Query: 525 VRTKKVGKNEAVL-EWDQLPVDVQNGFIRNYTIFYRTI---IGNETAVNVDSSHTEYTLS 580
N++++ +W P QNG ++ Y I Y +G + D+ L
Sbjct: 696 NVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLE 755
Query: 581 SLTSDTLYMVRMAAYTDEG 599
L T Y + +AAY G
Sbjct: 756 DLIIWTNYEIEVAAYNSAG 774
Score = 32.3 bits (72), Expect = 2.1
Identities = 25/91 (27%), Positives = 40/91 (43%), Gaps = 10/91 (10%)
Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWS----QIPPEDT 277
P PP ++ SS + + W++ I +Y I+ R D W IP E +
Sbjct: 1825 PGPPGVPIIVR---YSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVS 1881
Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
+ T F++ LKP Y FR+ + + G G
Sbjct: 1882 SYT---FSMDILKPGVSYDFRVIAVNDYGFG 1909
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 73.9 bits (180), Expect = 6e-13
Identities = 123/493 (24%), Positives = 199/493 (40%), Gaps = 64/493 (12%)
Query: 191 FVNIEVWVEAENALGK-VTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249
FV E+ V A +G V S + + P PP L V L+S+ ++ W P
Sbjct: 1346 FVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRL-VFPEVRLTSV-RIVWQPPEE 1403
Query: 250 KSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGY 309
+ IIL Y I YR +S + E A+ R FT DL P + Y+FR+ G
Sbjct: 1404 PNGIILGYQIAYRLASSSPHTFTTVEVGATVRQ-FTATDLAPESAYIFRLSAKTRQG--- 1459
Query: 310 WSDWSE--EASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDY- 366
W E EA+ IT E R AP + + R+++L W +P + I +
Sbjct: 1460 ---WGEPLEATVITTEKRERPAPPRELLVPQAEVTA-RSLRLQW--VPGSDGASPIRYFT 1513
Query: 367 ----EVTLTRWKSHLQNYTVNATKLTVNLTND--RYLATLTVRNLVGKSDAAVLTIPACD 420
E+ W+++ + + AT V+ Y L N +G SD + T
Sbjct: 1514 MQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTT 1573
Query: 421 FQAT--HPVMDLKAFPKD-NMLWVEWTTPRES-----VKKYILEWCVLSDKAPCITDW-- 470
Q P + A P + + ++W PR+ ++ Y + + L +A T+
Sbjct: 1574 LQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKT 1633
Query: 471 -------------QQEDGTVHR--TYLRGNLAESKCY-----LITVTPVYADGPGSPESI 510
Q TV+ T L K Y ++T + + P S +
Sbjct: 1634 LKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAP-V 1692
Query: 511 KAYLKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY-RTIIGNETAV 568
+ ++ +A P+ P V+ + ++ + WD P + QNG I+ Y I+Y NET
Sbjct: 1693 EVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEK 1752
Query: 569 N--VDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVC 626
+ L +LTS T Y+V ++A+ G DGP+ + P+ + A P
Sbjct: 1753 MKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAG--DGPK---SDPQQGRTHQAAPGAPSF 1807
Query: 627 LAF--LLTTLLGV 637
LAF + +T L V
Sbjct: 1808 LAFSEITSTTLNV 1820
Score = 58.9 bits (141), Expect = 2e-08
Identities = 86/402 (21%), Positives = 156/402 (38%), Gaps = 41/402 (10%)
Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTW----SQIPPEDT 277
P+ P NL V + S + L+W P + IL Y ++ +++ S W S + PE T
Sbjct: 668 PHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVEL-SENNSPWKVHLSNVGPEMT 726
Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKID 337
TV L P Y FR+ + E G+G +S E S + + P AP K
Sbjct: 727 G-----VTVSGLTPARTYQFRVCAVNEVGRG---QYSAETSRLMLPEEPPSAPP---KNI 775
Query: 338 PSHTQGYRTVQLVWKTLPPFEANGKILDY--EVTLTRWKSHLQNYTVNATKLTVNLTNDR 395
+ + +++ + W+ P E NG + Y L Q + + ++ L D
Sbjct: 776 VASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDL 835
Query: 396 YLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNM---------LWVEWTTP 446
+ T + + A + + T + + P N+ + W P
Sbjct: 836 IIWTQYEIQVAAYNGAGLGVFSRAVTEYT--LQGVPTAPPQNVQTEAVNSTTIQFLWNPP 893
Query: 447 RESVKKYI------LEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVY 500
+ I L W + +A + + VH ++ NL + Y +V
Sbjct: 894 PQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHIT-NLKKFTAYFTSVLCFT 952
Query: 501 ADGPGSPESIK-AYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYR 559
G G P + + + ++ P + ++ + W Q P++ +NG I Y I +
Sbjct: 953 TPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSW-QEPLE-KNGIITGYQISWE 1010
Query: 560 TIIGNETAV--NVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
N++ + ++S+ EY + L+S T Y + +AA T G
Sbjct: 1011 VYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVG 1052
Score = 52.8 bits (125), Expect = 1e-06
Identities = 122/527 (23%), Positives = 197/527 (37%), Gaps = 87/527 (16%)
Query: 125 PPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAK--RDTPTSC 182
P PKN+ + + +W ET E N L+ ++ A + + TS
Sbjct: 768 PSAPPKNIVASGRTNQSIMVQWQPPPET--EHNGVLRGYILRYRLAGLPGEYQQRNITSP 825
Query: 183 TVDYSTV----YFVNIEVWVEAENALGK-VTSDHINFDPVYKVKPNPPHNLSVINSEELS 237
V+Y V + E+ V A N G V S + + V PP N + +E ++
Sbjct: 826 EVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQN---VQTEAVN 882
Query: 238 SI-LKLTWTNPSIKSV--IILKYNIQYRTKDAS---TWSQIPPEDTASTRSSFTVQDLKP 291
S ++ W P + + I Y + DA T I P+ T +LK
Sbjct: 883 STTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHIT--NLKK 940
Query: 292 FTEYVFRIRCMKEDGKGYWSD----WSEEASGITYEDRPSKAP--SFWYKIDPSHTQGYR 345
FT Y + C G G S W T ED+P SF +D S
Sbjct: 941 FTAYFTSVLCFTTPGDGPPSTPQLVW-------TQEDKPGAVGHLSFTEILDTS------ 987
Query: 346 TVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQN-----YTVNATKLTVNLTNDRYLATL 400
+++ W+ P E NG I Y+++ W+ + +N +T+N+T + L T
Sbjct: 988 -LKVSWQE--PLEKNGIITGYQIS---WEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTY 1041
Query: 401 TVRNLVGKSDAAVLTIPACDFQATHPVM-----DLKAFPKDNMLWVEWTTPRE------- 448
T+ D A +T + + DL P + L + +PR
Sbjct: 1042 TI-------DVAAVTAVGTGLVTSSTISSGVPPDLPGAPSN--LVISNISPRSATLQFRP 1092
Query: 449 ------SVKKYILEWCV--LSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVY 500
S+ ++I+E V + D+ +T +++E+ + NL Y + V
Sbjct: 1093 GYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVN 1152
Query: 501 ADGPG--SPESIKAYLKQAPPSKGPT-VRTKKVGKNEAVLEWDQLPVDVQNGFIRN--YT 555
GP SP S QAPP PT V + + L W LP NG + Y
Sbjct: 1153 IVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYR 1212
Query: 556 I-FYRTIIGNETAVNV--DSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
I ++R+ + + V D E+T+ L Y ++M A+ G
Sbjct: 1213 IKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVG 1259
Score = 52.0 bits (123), Expect = 3e-06
Identities = 94/405 (23%), Positives = 154/405 (38%), Gaps = 45/405 (11%)
Query: 225 PHNLSVINSEELSSILKLTWT-------NPSIKSVIILKYNIQYRTKDASTWSQIPPEDT 277
P +++V + E S L+L W N + +SV Y I+Y D + S + +
Sbjct: 1177 PTSVTVRTASETS--LRLRWVPLPDSQYNGNPESV---GYRIKYWRSDLQS-SAVAQVVS 1230
Query: 278 ASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKID 337
FT+++L+ + EY +++ G G WSE G T E PS AP
Sbjct: 1231 DRLEREFTIEELEEWMEYELQMQAFNAVGAG---PWSEVVRGRTRESVPSAAPENVSAEA 1287
Query: 338 PSHTQGYRTVQLVWKTLPPFEANGKILDYEVTL------TRWKSHL--QNYTVNATKLTV 389
S TQ + L W ++P + NG IL Y++ +SH+ N+T +A +
Sbjct: 1288 VSSTQ----ILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGL 1343
Query: 390 NLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVE--WTTPR 447
L L + + L + A P + L FP+ + V W P
Sbjct: 1344 RKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRL-VFPEVRLTSVRIVWQPPE 1402
Query: 448 ES---VKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGP 504
E + Y + + + S T E G R + +LA Y+ ++ G
Sbjct: 1403 EPNGIILGYQIAYRLASSSPHTFT--TVEVGATVRQFTATDLAPESAYIFRLSAKTRQGW 1460
Query: 505 GSP---ESIKAYLKQAP-PSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRT 560
G P I ++ P P + V +V L+W +P IR +T+ R
Sbjct: 1461 GEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQW--VPGSDGASPIRYFTMQVRE 1518
Query: 561 IIGNE---TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKD 602
+ E + ++ T + L T Y +R+ A D G D
Sbjct: 1519 LPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSD 1563
Score = 47.0 bits (110), Expect = 8e-05
Identities = 93/424 (21%), Positives = 158/424 (37%), Gaps = 64/424 (15%)
Query: 221 KPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTAST 280
+P PP L V +E + L+L W S + I + +Q R W Q +
Sbjct: 1476 RPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEW-QTYSSSISHE 1534
Query: 281 RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGI-TYEDRPSKAPSFWYKIDPS 339
++ V L+PFT Y R++ + G SD+S E + T +D P + P P
Sbjct: 1535 ATACVVDRLRPFTSYKLRLKATNDIGD---SDFSSETEAVTTLQDVPGEPPGS-VSATPH 1590
Query: 340 HTQGYRTVQLVWKTLPPFEANGKI---------LDYEVTLTRWKSHLQN-------YTVN 383
T +V + W+ NG + L+YE L+N T
Sbjct: 1591 TTS---SVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQ 1647
Query: 384 ATKLTVNLTND-------------RYLATLTVRNLVGKSDA-AVLTIPACDFQATHPVMD 429
++ TVN ++ RY +T N++G+S A A + + + +
Sbjct: 1648 SSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQN 1707
Query: 430 LKAFP-KDNMLWVEW-TTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYL----- 482
++ P + L V W P ES I + + +A D Q E + +L
Sbjct: 1708 VQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEA----DSQNETEKMKVLFLPEPVV 1763
Query: 483 -RGNLAESKCYLITVTPVYA--DGPGS-PESIKAYLKQAPPSKGPTVRTKKVGKNEAVLE 538
NL YL++++ A DGP S P+ + + QA P + ++ +
Sbjct: 1764 RLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTH--QAAPGAPSFLAFSEITSTTLNVS 1821
Query: 539 WDQLPVDVQNGFIRNYTIFYRTI-----IGNETAVNVDSSHTEY-TLSSLTSDTLYMVRM 592
W + NG ++ Y + Y + + V V + + + LT Y R+
Sbjct: 1822 WGE--PAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRV 1879
Query: 593 AAYT 596
A T
Sbjct: 1880 QART 1883
Score = 30.4 bits (67), Expect = 7.9
Identities = 60/287 (20%), Positives = 109/287 (37%), Gaps = 53/287 (18%)
Query: 161 KSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGK--VTSDHINFDPVY 218
+ EW T+ + T+C VD F + ++ ++A N +G +S+ +
Sbjct: 1521 RGEWQTYS----SSISHEATACVVDRLRP-FTSYKLRLKATNDIGDSDFSSETEAVTTLQ 1575
Query: 219 KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSV--IILKYNIQYRT------------- 263
V PP ++S + +S + + W P +S+ ++ Y I YR
Sbjct: 1576 DVPGEPPGSVSA--TPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKT 1633
Query: 264 --------KDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSE 315
+ + S +++ST + + LK + Y + G+ S S
Sbjct: 1634 LKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGE---SPASA 1690
Query: 316 EASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKS 375
E P+ AP + +Q +++ W PP NG I Y++ W++
Sbjct: 1691 PVEVFVGEAAPAMAPQNVQVTPLTASQ----LEVTWDPPPPESQNGNIQGYKIYY--WEA 1744
Query: 376 HLQNYTVNATKLTV--------NLT-NDRYLATLTVRNLVG---KSD 410
QN T L + NLT + +YL +++ N G KSD
Sbjct: 1745 DSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSD 1791
>gi|24430212 interleukin 23 receptor precursor [Homo sapiens]
Length = 629
Score = 73.6 bits (179), Expect = 8e-13
Identities = 61/244 (25%), Positives = 112/244 (45%), Gaps = 18/244 (7%)
Query: 78 QYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQN-VYGITIISGLPPEKPKNLSCIV 136
Q T IN+T + + + + + + C ++ + G I SG PP+ P ++C++
Sbjct: 76 QITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVI 135
Query: 137 NE-GKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIE 195
E M C W+ G+ T+++T + + K + + ++ TS ++ ST +
Sbjct: 136 YEYSGNMTCTWNAGKLTYIDTKYVVHV-----KSLETEEEQQYLTSSYINISTDSLQGGK 190
Query: 196 ---VWVEAENALGKVTSD--HINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIK 250
VWV+A NALG S I+ D + IN+ +I + W + +
Sbjct: 191 KYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTI--IYWDSQT-- 246
Query: 251 SVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYW 310
++ + ++Y+ TW+ + DT T + L+P +YVF++RC +E GK YW
Sbjct: 247 TIEKVSCEMRYKATTNQTWN-VKEFDTNFTYVQQSEFYLEPNIKYVFQVRC-QETGKRYW 304
Query: 311 SDWS 314
WS
Sbjct: 305 QPWS 308
>gi|81158224 neuronal cell adhesion molecule isoform B precursor [Homo
sapiens]
Length = 1183
Score = 73.6 bits (179), Expect = 8e-13
Identities = 131/577 (22%), Positives = 219/577 (37%), Gaps = 72/577 (12%)
Query: 204 LGKVTSDHINFDPVYKVK--PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQY 261
+ T D ++ V V PNPP +L + +++L ++L+WT + I K+ I+Y
Sbjct: 611 VANTTLDSVSASAVLSVVDVPNPPFDLEL--TDQLDKSVQLSWTPGDDNNSPITKFIIEY 668
Query: 262 RTKDASTWSQIPPEDTASTRSSFTVQ-DLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGI 320
+DA + T + + T Q L P+ Y FR+ + GK S+ SE+ +
Sbjct: 669 --EDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQY--L 724
Query: 321 TYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTR------WK 374
T P K P+ ++ ++ V + WK L FE+NG L Y+V+ + W
Sbjct: 725 TKASEPDKNPT---AVEGLGSEPDNLV-ITWKPLNGFESNGPGLQYKVSWRQKDGDDEWT 780
Query: 375 S----HLQNYTVNATKLTVNLTNDRYLATLTVRNLVG--KSDAAVLTIPACDFQATHPVM 428
S ++ Y V+ T V YL + N +G A V+ D P
Sbjct: 781 SVVVANVSKYIVSGTPTFV-----PYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGN 835
Query: 429 DLKAFPKDNMLWVEW-TTPRESVKKY-----ILEWCVLSDKAPCITDWQQEDGTVHRTYL 482
+ V W P +S++ + I W S +++ T +
Sbjct: 836 VRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKT 895
Query: 483 RG---NLAESKCYLITVTPV--YADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVL 537
G L Y + V V +GP SP+ + + PS +++ + L
Sbjct: 896 HGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRV-FNTPEGVPSAPSSLKIVNPTLDSLTL 954
Query: 538 EWDQLPVDVQNGFIRNYTIFYRTI-----IGNETAVNVDSSHTEYTLSSLTSDTLYMVRM 592
EWD P NG + YT+ Y+ I +G + + ++ T +TL +L T Y
Sbjct: 955 EWD--PPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYF 1012
Query: 593 AAYTDEG-GKDGPEFTFTTPKFAQGEIEAIV------VPVCLAFLLTTLLGVLFCFNKRD 645
A T G G E TT A + + + + A L L+ ++ CF +R+
Sbjct: 1013 YAQTSAGSGSQITEEAVTTVDEAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRN 1072
Query: 646 LIKK---------HIWPNV-----PDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDV 691
K H P + D + + H P + + +D
Sbjct: 1073 KGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDD 1132
Query: 692 SVVEIEANDKKPFPEDLKSLDLF--KKEKINTEGHSS 726
S+V+ F ED + + KKEK EG+ S
Sbjct: 1133 SLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNES 1169
>gi|4506107 prolactin receptor [Homo sapiens]
Length = 622
Score = 73.2 bits (178), Expect = 1e-12
Identities = 57/203 (28%), Positives = 92/203 (45%), Gaps = 21/203 (10%)
Query: 124 LPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTL----KSEWATHKFADCKAKRDTP 179
LPP KP+ C + C W G + L TN++L + E H+ D P
Sbjct: 26 LPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYIT--GGP 83
Query: 180 TSCTV--DYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLS--VINSEE 235
SC Y++++ I + V A N +G SD + D Y V+P+PP L+ V E+
Sbjct: 84 NSCHFGKQYTSMWRTYI-MMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPED 142
Query: 236 LSSILKLTWTNPSIKSV----IILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKP 291
L + W+ P++ + L Y I+ + + A+ W A ++ F + L P
Sbjct: 143 RKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWE----IHFAGQQTEFKILSLHP 198
Query: 292 FTEYVFRIRCMKEDGKGYWSDWS 314
+Y+ ++RC + GYWS WS
Sbjct: 199 GQKYLVQVRCKPD--HGYWSAWS 219
>gi|81158226 neuronal cell adhesion molecule isoform A precursor [Homo
sapiens]
Length = 1304
Score = 73.2 bits (178), Expect = 1e-12
Identities = 108/444 (24%), Positives = 177/444 (39%), Gaps = 57/444 (12%)
Query: 216 PVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPE 275
PVY V PNPP +L + +++L ++L+WT + I K+ I+Y +DA +
Sbjct: 642 PVYDV-PNPPFDLEL--TDQLDKSVQLSWTPGDDNNSPITKFIIEY--EDAMHKPGLWHH 696
Query: 276 DTASTRSSFTVQ-DLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWY 334
T + + T Q L P+ Y FR+ + GK S+ SE+ +T P K P+
Sbjct: 697 QTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQY--LTKASEPDKNPT--- 751
Query: 335 KIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTR------WKS----HLQNYTVNA 384
++ ++ V + WK L FE+NG L Y+V+ + W S ++ Y V+
Sbjct: 752 AVEGLGSEPDNLV-ITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSG 810
Query: 385 TKLTVNLTNDRYLATLTVRNLVG--KSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVE 442
T V YL + N +G A V+ D P + V
Sbjct: 811 TPTFV-----PYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVH 865
Query: 443 W-TTPRESVKKY-----ILEWCVLSDKAPCITDWQQEDGTVHRTYLRG---NLAESKCYL 493
W P +S++ + I W S +++ T + G L Y
Sbjct: 866 WDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYT 925
Query: 494 ITVTPV--YADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFI 551
+ V V +GP SP+ + + PS +++ + LEWD P NG +
Sbjct: 926 LNVRVVNGKGEGPASPDRV-FNTPEGVPSAPSSLKIVNPTLDSLTLEWD--PPSHPNGIL 982
Query: 552 RNYTIFYRTI-----IGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG-GKDGPE 605
YT+ Y+ I +G + + ++ T +TL +L T Y A T G G E
Sbjct: 983 TEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITE 1042
Query: 606 FTFTT--------PKFAQGEIEAI 621
TT P G+++A+
Sbjct: 1043 EAVTTVDEAGILPPDVGAGKVQAV 1066
Score = 45.1 bits (105), Expect = 3e-04
Identities = 151/791 (19%), Positives = 277/791 (35%), Gaps = 128/791 (16%)
Query: 23 ELLDPCGYIS-PESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTI 81
E+ DP + PE VVQ S + C +K H + ++W ++ +P ++
Sbjct: 541 EIKDPTWIVKQPEYAVVQRGSMVSFECKVKHD-----HTLSLTVLWLKDNRELPSDERFT 595
Query: 82 INR--------------TASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPE 127
+++ T + V T + S++ +++ VY + P
Sbjct: 596 VDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDV-------PN 648
Query: 128 KPKNLSCIVNEGKKMRCEWDGGRETHLE-TNFTLKSEWATHKFADCKAKRDTP-TSCTVD 185
P +L K ++ W G + + T F ++ E A HK + + T T
Sbjct: 649 PPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQ 708
Query: 186 YSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWT 245
+VN V A N++GK + + K + +V L +TW
Sbjct: 709 LKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWK 768
Query: 246 --NPSIKSVIILKYNIQYRTKDAST-WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCM 302
N + L+Y + +R KD W+ + + S + V F Y+ +++ +
Sbjct: 769 PLNGFESNGPGLQYKVSWRQKDGDDEWTSV----VVANVSKYIVSGTPTFVPYLIKVQAL 824
Query: 303 KEDGKGYWSDWSEEASGITYEDRPSKAPS--------------FW----YKIDPSHTQGY 344
+ G ++ G + ED P AP W K H QGY
Sbjct: 825 NDMG---FAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGY 881
Query: 345 RTVQLVWKTLPPFEANGKILDYEV-TLTRWKSH--------LQNYTVNATKLTVNLTNDR 395
R WKT + N + ++ ++ T K+H +YT+N V + N +
Sbjct: 882 RIYY--WKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLN-----VRVVNGK 934
Query: 396 YLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRES---VKK 452
+ + V + V + P+ + +P +D L +EW P + +
Sbjct: 935 GEGPASP-DRVFNTPEGVPSAPS-SLKIVNPTLD--------SLTLEWDPPSHPNGILTE 984
Query: 453 YILEWCVLS---DKAPCI--------TDWQQED---GTVHRTYLRGNLAESKCYLIT--- 495
Y L++ ++ + P + T W ++ T ++ Y + IT
Sbjct: 985 YTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEA 1044
Query: 496 VTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYT 555
VT V G P+ ++ P T + A + W+ + N ++
Sbjct: 1045 VTTVDEAGILPPDVGAGKVQAVNPRISNL--TAAAAETYANISWEYEGPEHVNFYVEYGV 1102
Query: 556 IFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQ 615
+ E V+ S + + L L T Y VR+ A D G + T P A
Sbjct: 1103 AGSKEEWRKEI---VNGSRSFFGLKGLMPGTAYKVRVGAVGDSGFVSSEDVFETGPAMAS 1159
Query: 616 GEIEAIV----VPVCLAFLLTTLLGVLFCFNKRDLIKK---------HIWPNV-----PD 657
+++ + + A L L+ ++ CF +R+ K H P + D
Sbjct: 1160 RQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDD 1219
Query: 658 PSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLF--K 715
+ + H P + + +D S+V+ F ED + + K
Sbjct: 1220 GTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGK 1279
Query: 716 KEKINTEGHSS 726
KEK EG+ S
Sbjct: 1280 KEKEPAEGNES 1290
>gi|22212918 ciliary neurotrophic factor receptor preproprotein
[Homo sapiens]
Length = 372
Score = 67.4 bits (163), Expect = 6e-11
Identities = 56/209 (26%), Positives = 87/209 (41%), Gaps = 13/209 (6%)
Query: 123 GLPPEKPKNLSCIVNEGKK-MRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTS 181
GLPP +P LSC N K C W T++ F + + K C+
Sbjct: 106 GLPPREPV-LSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGS-KIMVCEKDPALKNR 163
Query: 182 CTVDYSTVYF-VNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240
C + Y ++ + +V + NALG + I FD VKP+PP N+ L
Sbjct: 164 CHIRYMHLFSTIKYKVSISVSNALGH-NATAITFDEFTIVKPDPPENVVARPVPSNPRRL 222
Query: 241 KLTWTNPSI---KSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVF 297
++TW PS LK+ ++YR W + D ++ T+ D EY+
Sbjct: 223 EVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDG----TAHTITDAYAGKEYII 278
Query: 298 RIRCMKEDGKGYWSDWSEEASGITYEDRP 326
++ K++ G WSDWS A + + P
Sbjct: 279 QVAA-KDNEIGTWSDWSVAAHATPWTEEP 306
>gi|4502931 ciliary neurotrophic factor receptor preproprotein [Homo
sapiens]
Length = 372
Score = 67.4 bits (163), Expect = 6e-11
Identities = 56/209 (26%), Positives = 87/209 (41%), Gaps = 13/209 (6%)
Query: 123 GLPPEKPKNLSCIVNEGKK-MRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTS 181
GLPP +P LSC N K C W T++ F + + K C+
Sbjct: 106 GLPPREPV-LSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGS-KIMVCEKDPALKNR 163
Query: 182 CTVDYSTVYF-VNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL 240
C + Y ++ + +V + NALG + I FD VKP+PP N+ L
Sbjct: 164 CHIRYMHLFSTIKYKVSISVSNALGH-NATAITFDEFTIVKPDPPENVVARPVPSNPRRL 222
Query: 241 KLTWTNPSI---KSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVF 297
++TW PS LK+ ++YR W + D ++ T+ D EY+
Sbjct: 223 EVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDG----TAHTITDAYAGKEYII 278
Query: 298 RIRCMKEDGKGYWSDWSEEASGITYEDRP 326
++ K++ G WSDWS A + + P
Sbjct: 279 QVAA-KDNEIGTWSDWSVAAHATPWTEEP 306
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 61.6 bits (148), Expect = 3e-09
Identities = 133/570 (23%), Positives = 211/570 (37%), Gaps = 63/570 (11%)
Query: 70 NHFTIPKEQYTIINRTASSVTFTDIASLNIQLTC----NILTFGQLEQNVYGI--TIISG 123
+H+ I K + + ++ T S T++ +LN ++T N F + N YGI + SG
Sbjct: 24835 SHYIIEKRETSRLSWTQVS---TEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESG 24891
Query: 124 --------LPPEKPKNLSCIVNEGKKMRCEW-----DGGRETHLETNFTLKSEWATHKFA 170
PP P M W DGG T +E K + ++
Sbjct: 24892 PVTACNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGG--TEIEGYILEKRDKEGVRWT 24949
Query: 171 DCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENA--LGKVTSDHINF---DPVYKVKPNPP 225
C K T V T + E V AENA +G+ + + + D +Y P PP
Sbjct: 24950 KCNKKTLTDLRLRVTGLTEGH-SYEFRVAAENAAGVGEPSEPSVFYRACDALYP--PGPP 25006
Query: 226 HNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQIPPEDTASTRSSF 284
N V ++ S + L W+ P +K Y ++ + A W+ P T F
Sbjct: 25007 SNPKVTDTSRSS--VSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPP-TGLQGKQF 25063
Query: 285 TVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEAS--GITYEDRPSKAPSFWYKIDPSHTQ 342
TV LK TEY FRI + +G G E A+ G + P D
Sbjct: 25064 TVTKLKENTEYNFRICAINSEGVG------EPATLPGSVVAQERIEPPEIELDADLRKVV 25117
Query: 343 GYR---TVQL--VWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYL 397
R T++L K P E + + +T ++T+ + RY
Sbjct: 25118 VLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRY- 25176
Query: 398 ATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTP----RESVKKY 453
LT+ N G S A + + D + + ++ KD++ + W P + Y
Sbjct: 25177 -NLTLENNSG-SKTAFVNVRVLDSPSAPVNLTIREVKKDSVT-LSWEPPLIDGGAKITNY 25233
Query: 454 ILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSP-ESIKA 512
I+E + KA + T+ NL E Y V G G P E+ +
Sbjct: 25234 IVEKRETTRKAYATI----TNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEP 25289
Query: 513 YLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDS 572
PP V V +N A ++W++ P I Y + +T + +
Sbjct: 25290 VKVSEPPLPPGRVTLVDVTRNTATIKWEK-PESDGGSKITGYVVEMQTKGSEKWSTCTQV 25348
Query: 573 SHTEYTLSSLTSDTLYMVRMAAYTDEGGKD 602
E T+S LT+ Y+ R+AA ++G D
Sbjct: 25349 KTLEATISGLTAGEEYVFRVAAVNEKGRSD 25378
Score = 59.3 bits (142), Expect = 2e-08
Identities = 115/452 (25%), Positives = 173/452 (38%), Gaps = 58/452 (12%)
Query: 195 EVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELS-SILKLTWTNPSIKSVI 253
E V AENA G + I+ + NPP +V+ + S + + L W+ P +
Sbjct: 28224 EFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGM 28283
Query: 254 -ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSD 312
I+ Y I+ D W ++ E TR +TV DL+ EY FR+ + GKG D
Sbjct: 28284 EIIGYIIEMCKADLGDWHKVNAEACVKTR--YTVTDLQAGEEYKFRVSAINGAGKG---D 28338
Query: 313 WSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRT-----VQLVWKTLPPFEANGKILDYE 367
E I DR + AP + T R + + ++ P A D
Sbjct: 28339 SCEVTGTIKAVDRLT-APELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSN 28397
Query: 368 VTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPV 427
++L R H + T N ND TLTV N G S + T+ D
Sbjct: 28398 LSL-RADIHTTDSFSTLTVENCN-RNDAGKYTLTVENNSG-SKSITFTVKVLDTPGPPGP 28454
Query: 428 MDLKAFPKDNMLWVEWTTP----RESVKKYILE--------WCVLSDKAPCITDWQQEDG 475
+ K + + + W P + Y++E W V+S+K
Sbjct: 28455 ITFKDVTRGSAT-LMWDAPLLDGGARIHHYVVEKREASRRSWQVISEKC----------- 28502
Query: 476 TVHRTYLRGNLAESKCYLITVTPVYADGPGS----PESIKAYLKQAPPSKGPTVRTKKVG 531
+ + +LAE Y V+ V G G PE I A + APP + V T
Sbjct: 28503 -TRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDT---S 28558
Query: 532 KNEAVLEWDQLPVDVQNGF-IRNYTIFYRTIIGNETAVNVDSSHTE---YTLSSLTSDTL 587
K+ AVL W L D G I Y + R + V++ HT+ +T+ L T
Sbjct: 28559 KSSAVLAW--LKPDHDGGSRITGYLLEMRQ---KGSDFWVEAGHTKQLTFTVERLVEKTE 28613
Query: 588 YMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIE 619
Y R+ A D G + P F++ + +IE
Sbjct: 28614 YEFRVKAKNDAGYSE-PREAFSSVIIKEPQIE 28644
Score = 55.5 bits (132), Expect = 2e-07
Identities = 100/407 (24%), Positives = 147/407 (36%), Gaps = 49/407 (12%)
Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQIPPEDTAST 280
P PP +L V S+ +L+W P +K Y I+ RT D W+++ P+ ++T
Sbjct: 15912 PGPPKDLKV--SDITRGSCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTT 15969
Query: 281 RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSH 340
F V DL +Y FR+R G G E T D P P K+
Sbjct: 15970 ---FVVPDLLSEQQYFFRVRAENRFGIG---PPVETIQRTTARD-PIYPPDPPIKLKIGL 16022
Query: 341 TQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWK---------SHLQNYTVNATKLTVN- 390
TV L WK P + + Y V W V + TV
Sbjct: 16023 IT-KNTVHLSWKP-PKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVED 16080
Query: 391 -LTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATH--PVMDLKAFPK-DNMLWVEWTTP 446
+ Y + N G S + T+ CD Q P +DLK F + + V
Sbjct: 16081 LVEGGEYEFRVKAVNAAGVSKPSA-TVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAK 16139
Query: 447 RESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLI------------ 494
+ V L W K P ++ ++ T++ + + C L+
Sbjct: 16140 IKGVPFPTLTWFKAPPKKP-----DNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLY 16194
Query: 495 TVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNY 554
T+T V G S E L + P GP ++ + V ++ L W P D I NY
Sbjct: 16195 TITAVNNLGTASKEMRLNVLGRPGPPVGP-IKFESVSADQMTLSWFP-PKDDGGSKITNY 16252
Query: 555 TIFYRTIIGNETAVNVDSSHTE--YTLSSLTSDTLYMVRMAAYTDEG 599
I R +T V+V S E YT+ L Y+ R+ A G
Sbjct: 16253 VIEKRE-ANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYG 16298
Score = 54.7 bits (130), Expect = 4e-07
Identities = 139/610 (22%), Positives = 219/610 (35%), Gaps = 94/610 (15%)
Query: 77 EQYTIINRTASSVTFTDIASLNIQLTC---------NILTFGQLEQNVYGI--------- 118
+ Y + R S + +T++AS +Q+T N F + N YG+
Sbjct: 21588 DHYIVQKRETSRLAWTNVAS-EVQVTKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPV 21646
Query: 119 -TIISGLPPEKPKNLSCIVNEGKKMRCEW-----DGGRETHLETNFTL-KSEWATHKFAD 171
+ PP+ PKN M W DGG E N+ + + + A ++
Sbjct: 21647 LAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEI---INYIVERRDKAGQRWIK 21703
Query: 172 CKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKV-----KPNPPH 226
C K T V T E + AENA G S P YK KP PP
Sbjct: 21704 CNKKTLTDLRYKVSGLTEGH-EYEFRIMAENAAG--ISAPSPTSPFYKACDTVFKPGPPG 21760
Query: 227 NLSVINSEELSSILKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQI-PPEDTASTRSSF 284
N V+++ S + + W P I Y ++ + W + PP +T S+
Sbjct: 21761 NPRVLDTSRSS--ISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKAT--SY 21816
Query: 285 TVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGY 344
T+ L EY RI M +G G G + P D
Sbjct: 21817 TITGLTENQEYKIRIYAMNSEGLGE----PALVPGTPKAEDRMLPPEIELDADLRKVVTI 21872
Query: 345 RT-------VQLVWKTLPPFE---ANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTN- 393
R V + + P + +G+ LD K+ +++ T + T L V N
Sbjct: 21873 RACCTLRLFVPIKGRPAPEVKWARDHGESLD--------KASIES-TSSYTLLIVGNVNR 21923
Query: 394 -DRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTP----RE 448
D LTV N G S +A + + D + +K K ++ + W P
Sbjct: 21924 FDSGKYILTVENSSG-SKSAFVNVRVLDTPGPPQDLKVKEVTKTSVT-LTWDPPLLDGGS 21981
Query: 449 SVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKC-YLITVTPVYADGPGSP 507
+K YI+E + KA + H+T + + + C Y V G G P
Sbjct: 21982 KIKNYIVEKRESTRKA-----YSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLP 22036
Query: 508 ----ESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIG 563
ES+KA + PP K + V +N L W++ P I Y + +T
Sbjct: 22037 AETAESVKASERPLPPGK---ITLMDVTRNSVSLSWEK-PEHDGGSRILGYIVEMQTKGS 22092
Query: 564 NETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVV 623
++ A TE T++ L Y R++A ++G D + + P A+ +V+
Sbjct: 22093 DKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPRQ--LSVPVIAKD----LVI 22146
Query: 624 PVCLAFLLTT 633
P L T
Sbjct: 22147 PPAFKLLFNT 22156
Score = 54.7 bits (130), Expect = 4e-07
Identities = 102/436 (23%), Positives = 167/436 (38%), Gaps = 54/436 (12%)
Query: 195 EVWVEAENALG----KVTSDHINF-DPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249
E V AENA G TS I DPV+ P+PP +++S + + + + W P
Sbjct: 26054 EYRVYAENAAGLSLPSETSPLIRAEDPVFL--PSPPSKPKIVDSGKTT--ITIAWVKPLF 26109
Query: 250 KS-VIILKYNIQYRTKDASTWSQIPPEDTASTRSS-FTVQDLKPFTEYVFRIRCMKEDGK 307
I Y ++Y+ D + W S R + +T+ L EYVFR++ + + G
Sbjct: 26110 DGGAPITGYTVEYKKSDDTDWKT----SIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGA 26165
Query: 308 GYWSDWSEEASGITYEDRP------SKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANG 361
SD S+ E+ P + K S T TV + +P
Sbjct: 26166 SDPSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTM---TVPFRGRPVP-----N 26217
Query: 362 KILDYEVTLTRWKSHLQNYTVNATKLTVNLT--NDRYLATLTVRNLVGKSDAAVLTIPAC 419
+ T R ++++ T + T LT+ ND TLT++N++ + + L +
Sbjct: 26218 VLWSKPDTDLRTRAYVDT-TDSRTSLTIENANRNDSGKYTLTIQNVLSAA-SLTLVVKVL 26275
Query: 420 DFQATHPVMDLKAFPKDNMLWVEWTTPRES----VKKYILEWCVLSDKAPCITDWQQEDG 475
D + ++ K++ + + W P VK Y +E S KA W
Sbjct: 26276 DTPGPPTNITVQDVTKESAV-LSWDVPENDGGAPVKNYHIEKREASKKA-----WVSVTN 26329
Query: 476 TVHR-TYLRGNLAESKCYLITVTPVYADGPGSP----ESIKAYLKQAPPSKGPTVRTKKV 530
+R +Y NL E Y V+ G G P E +K K +PP K + +
Sbjct: 26330 NCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEK---LGVTSI 26386
Query: 531 GKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVN-VDSSHTEYTLSSLTSDTLYM 589
K+ L W L + G + + G + V + T + +S L ++ Y
Sbjct: 26387 SKDSVSLTW--LKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLRENSEYF 26444
Query: 590 VRMAAYTDEGGKDGPE 605
R+ A G D E
Sbjct: 26445 FRVFAENQAGLSDPRE 26460
Score = 54.3 bits (129), Expect = 5e-07
Identities = 73/261 (27%), Positives = 103/261 (39%), Gaps = 40/261 (15%)
Query: 198 VEAENALGKVTSDHINFDPVYKVK-----PNPPHNLSVINSEELSSILKLTWTNPSIKS- 251
V A N +G T + + D + + P PP N+++ + + LTW P
Sbjct: 13164 VSARNRVG--TGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFG--VSLTWEPPEYDGG 13219
Query: 252 VIILKYNIQYRTKDASTWSQIPPEDTASTRS----SFTVQDLKPFTEYVFRIRCMKEDGK 307
I Y I+ R K + W DTA T S TV D+ EY FR+R G
Sbjct: 13220 AEITNYVIELRDKTSIRW------DTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGV 13273
Query: 308 GYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGK-ILDY 366
G S + +RPS + S Q +VQL W+ PP + G IL Y
Sbjct: 13274 GKPSAATPFVKVADPIERPSPPVNL-----TSSDQTQSSVQLKWE--PPLKDGGSPILGY 13326
Query: 367 EVTLTRWKSHLQNYTVNATKLTVNLT--------NDRYLATLTVRNLVGKSDAAVLTIP- 417
+ R + N+ KL LT ++YL ++ N G SD + + P
Sbjct: 13327 --IIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPL 13384
Query: 418 ACDFQATHPVMDLKAFPKDNM 438
D P MDL AF KD +
Sbjct: 13385 TADDAFVEPTMDLSAF-KDGL 13404
Score = 53.1 bits (126), Expect = 1e-06
Identities = 98/420 (23%), Positives = 159/420 (37%), Gaps = 36/420 (8%)
Query: 198 VEAENALGKVT-SDHINF----DPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKS- 251
V A NA G S+ NF +P Y P PP V+++ + S + L WT P
Sbjct: 29315 VTAVNAAGNSEPSEASNFISCREPSYT--PGPPSAPRVVDTTKHS--ISLAWTKPMYDGG 29370
Query: 252 VIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWS 311
I+ Y ++ + KD W ++ T + FTV DLK +Y FR+ + G S
Sbjct: 29371 TDIVGYVLEMQEKDTDQWYRVHTNATIRN-TEFTVPDLKMGQKYSFRVAAVNVKG---MS 29426
Query: 312 DWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLT 371
++SE + I +R + P D T R + + ++ +
Sbjct: 29427 EYSESIAEIEPVER-IEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGI 29485
Query: 372 RWKSHLQNYTVNATKLTVNLTNDRYLA---TLTVRNLVGKSDAAVLTIPACDFQATHPVM 428
S T + L + +RY A T+ N GK A VL + D P +
Sbjct: 29486 DLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVL-VKVYDTPGPCPSV 29544
Query: 429 DLKAFPKDNMLWVEWTTPR----ESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLR- 483
+K +D++ + W P V YI+E + + ++ +T R
Sbjct: 29545 KVKEVSRDSVT-ITWEIPTIDGGAPVNNYIVE-----KREAAMRAFKTVTTKCSKTLYRI 29598
Query: 484 GNLAESKCYLITVTPVYADGPGSP-ESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQL 542
L E Y V P G G P E+ A L P + V K+ L W++
Sbjct: 29599 SGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEK- 29657
Query: 543 PVDVQNGFIRNYTIFYRTIIGNE---TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
P+ + Y + G E V + + E+T++SL Y+ R+ A ++G
Sbjct: 29658 PLYDGGSRLTGY-VLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKG 29716
Score = 51.6 bits (122), Expect = 3e-06
Identities = 99/421 (23%), Positives = 165/421 (39%), Gaps = 46/421 (10%)
Query: 201 ENALGKVTSDHINFDPVYKV--KPNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILKY 257
EN+ GK + V KV P PP N++V + S+ + TW P I I+ Y
Sbjct: 19769 ENSCGKK-----EYTIVVKVLDTPGPPVNVTVKEISKDSAYV--TWEPPIIDGGSPIINY 19821
Query: 258 NIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEA 317
+Q R + +WS + E +++SF V +L+ Y FR+ E G G D E
Sbjct: 19822 VVQKRDAERKSWSTVTTE---CSKTSFRVANLEEGKSYFFRVFAENEYGIG---DPGETR 19875
Query: 318 SGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTL----TRW 373
+ P P K+ + + + WK P + +I+ Y V +W
Sbjct: 19876 DAVKASQTP--GPVVDLKV---RSVSKSSCSIGWKK-PHSDGGSRIIGYVVDFLTEENKW 19929
Query: 374 KSHLQNYTV--NATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLK 431
+ +++ ++ +A LT Y ++ N G+ + +T+ A D P +DLK
Sbjct: 19930 QRVMKSLSLQYSAKDLT---EGKEYTFRVSAENENGEGTPSEITVVARD-DVVAPDLDLK 19985
Query: 432 AFP------KDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGN 485
P K+N + P + + W D T E V+ T + +
Sbjct: 19986 GLPDLCYLAKENSNF-RLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYD 20044
Query: 486 LAESKC--YLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLP 543
+S Y IT+ V G+ SIK K P+ GP ++ +V L+W P
Sbjct: 20045 CQKSDAGKYTITLKNVAGTKEGT-ISIKVVGKPGIPT-GP-IKFDEVTAEAMTLKWAP-P 20100
Query: 544 VDVQNGFIRNYTIFYRTIIGNETAVNVDS-SHTEYTLSSLTSDTLYMVRMAAYTDEGGKD 602
D I NY + R + N+ + T + ++ L Y R++A G +
Sbjct: 20101 KDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGE 20160
Query: 603 G 603
G
Sbjct: 20161 G 20161
Score = 49.3 bits (116), Expect = 2e-05
Identities = 95/411 (23%), Positives = 150/411 (36%), Gaps = 64/411 (15%)
Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQIPPEDTAST 280
P PP NL+V + S+ L W P I +K Y I R ++ + + +
Sbjct: 24116 PGPPQNLAVKEVRKDSAFL--VWEPPIIDGGAKVKNYVIDKRESTRKAYANV---SSKCS 24170
Query: 281 RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSH 340
++SF V++L Y FR+ E G G E P P D S
Sbjct: 24171 KTSFKVENLTEGAIYYFRVMAENEFGVGV----PVETVDAVKAAEPPSPPGKVTLTDVSQ 24226
Query: 341 TQGYRTVQLVWKTLPPFEANGKILDYEVTL-----TRWKSHLQNYTVNATKLTVNLTNDR 395
T + L+W+ P + ++L Y V + +W ++ NA +T +
Sbjct: 24227 T----SASLMWEK-PEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAV-VTGLSSGQE 24280
Query: 396 YLATLTVRNLVGKSDAAVLTIPACDFQAT-HPVM-------------DLK------AFPK 435
Y + N GKSD VL +P T P + DLK P+
Sbjct: 24281 YQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPR 24340
Query: 436 DNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLR-GNLAESKCYLI 494
N+ WV+ P + + +E E T +++ GN + Y
Sbjct: 24341 PNISWVKDGEPLKQTTRVNVE----------------ETATSTVLHIKEGNKDDFGKY-- 24382
Query: 495 TVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNY 554
TVT + G + L++ P GP VR +V + V+ W+ P I NY
Sbjct: 24383 TVTATNSAGTATENLSVIVLEKPGPPVGP-VRFDEVSADFVVISWEP-PAYTGGCQISNY 24440
Query: 555 TIFYR-TIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGP 604
+ R T V+ + T ++ L + T Y R+ A + GK P
Sbjct: 24441 IVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFA-ENRYGKSAP 24490
Score = 47.0 bits (110), Expect = 8e-05
Identities = 80/358 (22%), Positives = 137/358 (38%), Gaps = 50/358 (13%)
Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTAST 280
P P +L V S+ + ++W P + Y ++ R D TWS + PE
Sbjct: 18699 PGPVSDLKV--SDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPE---VK 18753
Query: 281 RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSH 340
++SF V +L P EY FR+ + E G G +D + P P K++ +
Sbjct: 18754 KTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKP----VLASDPLSEPDPPRKLEVTE 18809
Query: 341 TQGYRTVQLVWKTLPPFEANGKILDYEVT--------LTRWKSH--LQNYTVNATKLTVN 390
+ L W LPP G +D +T RW + +++ ++ T L
Sbjct: 18810 -MTKNSATLAW--LPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLK-- 18864
Query: 391 LTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESV 450
+Y + RN VG +++P + + + + PK +L E T +
Sbjct: 18865 -EGKKYKFRVAARNAVG------VSLPR-EAEGVYEAKEQLLPPK--ILMPEQITIKAG- 18913
Query: 451 KKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLI------------TVTP 498
KK +E V P + ED V ++L + A+S LI ++T
Sbjct: 18914 KKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTA 18973
Query: 499 VYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTI 556
+ G + + IK + AP P + + L W +P++ I NY +
Sbjct: 18974 ENSSGTDT-QKIKVVVMDAPGPPQPPFDISDIDADACSLSW-HIPLEDGGSNITNYIV 19029
Score = 46.6 bits (109), Expect = 1e-04
Identities = 65/276 (23%), Positives = 111/276 (40%), Gaps = 35/276 (12%)
Query: 149 GRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVT 208
G+E T+K++ + A + P S D + +Y + +E N LG T
Sbjct: 14424 GKEVKASDRLTMKNDHIS-------AHLEVPKSVRAD-AGIYTITLE------NKLGSAT 14469
Query: 209 SDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKS-VIILKYNIQYRTKDAS 267
+ IN + P P ++ S+ S KLTW P IL Y ++ R
Sbjct: 14470 AS-INVKVIGL--PGPCKDIKA--SDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRR 14524
Query: 268 TWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPS 327
T+ P + + S+TV+DL P EY FR++ + + G G ++ E + + +D P
Sbjct: 14525 TYI---PVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGG---EYIELKNPVIAQD-PK 14577
Query: 328 KAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTL-----TRWKSHLQNYTV 382
+ P ++ H + + WK P ++ KI+ Y + RWK ++
Sbjct: 14578 QPPDPPVDVE-VHNPTAEAMTITWKP-PLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVP 14635
Query: 383 NATKLTVNLTNDR-YLATLTVRNLVGKSDAAVLTIP 417
T L + Y + N G S+ + T P
Sbjct: 14636 ILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPP 14671
Score = 45.8 bits (107), Expect = 2e-04
Identities = 72/342 (21%), Positives = 136/342 (39%), Gaps = 44/342 (12%)
Query: 221 KPNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTAS 279
+P PP L V+++ + S++L W P I Y ++ R K + W E +
Sbjct: 28545 QPAPPRRLDVVDTSKSSAVL--AWLKPDHDGGSRITGYLLEMRQKGSDFWV----EAGHT 28598
Query: 280 TRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPS 339
+ +FTV+ L TEY FR++ + G +S+ E S + ++ +I+P+
Sbjct: 28599 KQLTFTVERLVEKTEYEFRVKAKNDAG---YSEPREAFSSVIIKEP---------QIEPT 28646
Query: 340 HTQGYRTVQLV-WKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNAT-KLTVNLTNDRYL 397
T QL+ K PF + I WK L+ + T ++++ T DR
Sbjct: 28647 ADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWK--LEEMRLKETDRVSITTTKDRTT 28704
Query: 398 AT-------------LTVRNLVG-KSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEW 443
T LT+ N G K+ + + + T P+ ++ + ++ + + W
Sbjct: 28705 LTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPI-EVSSVSAESCV-LSW 28762
Query: 444 TTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLR-GNLAESKCYLITVTPVYAD 502
P++ I + ++ + T WQ + +V RT ++ +L + Y V+
Sbjct: 28763 GEPKDGGGTEITNY-IVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSSENRF 28821
Query: 503 GPGSPESIKAYLKQ---APPSKGPTVRTKKVGKNEAVLEWDQ 541
G P + + PPS V N + W++
Sbjct: 28822 GVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWEE 28863
Score = 44.3 bits (103), Expect = 5e-04
Identities = 94/374 (25%), Positives = 145/374 (38%), Gaps = 39/374 (10%)
Query: 241 KLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRI 299
KLTW +P I Y I+ R D W+ P TR + TVQ L Y FRI
Sbjct: 16634 KLTWFSPEDDGGSPITNYVIEKRESDRRAWT---PVTYTVTRQNATVQGLIQGKAYFFRI 16690
Query: 300 RCMKEDGKGYWSDWSEE---ASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPP 356
G G + + SE IT +RP TV L W P
Sbjct: 16691 AAENSIGMGPFVETSEALVIREPITVPERPEDL--------EVKEVTKNTVTLTWNP-PK 16741
Query: 357 FEANGKILDYEV---TLTRWKSH-LQNYTVNATKLTVN--LTNDRYLATLTVRNLVGKSD 410
++ +I++Y + + K H + N + + K TV D Y ++ N+VG+
Sbjct: 16742 YDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGK 16801
Query: 411 AAVLTIP-ACDFQATHPVMDLKAFPKDNMLWVE--WTTPRESVK-KYILEWCVLSDKAPC 466
+ T P C + P + L K + E T R S K K + W D+A
Sbjct: 16802 PSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSW--FKDEADV 16859
Query: 467 ITDWQQEDGTVHRTY----LRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKG 522
+ D + T T ++ ++S Y + V G + + + PP G
Sbjct: 16860 LEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQ-VNVVDRPGPP-VG 16917
Query: 523 PTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYT--LS 580
P V +V K+ V+ W + P+D I NY I + +G + + V S+ + T +S
Sbjct: 16918 P-VSFDEVTKDYMVISW-KPPLDDGGSKITNY-IIEKKEVGKDVWMPVTSASAKTTCKVS 16974
Query: 581 SLTSDTLYMVRMAA 594
L Y+ R+ A
Sbjct: 16975 KLLEGKDYIFRIHA 16988
Score = 44.3 bits (103), Expect = 5e-04
Identities = 47/184 (25%), Positives = 76/184 (41%), Gaps = 22/184 (11%)
Query: 164 WATHKFAD-CKAKRDTP---TSCTVDYSTVYFVNIE------VWVEAENALGKVTSDHIN 213
W T+ + C+AK S + +T VN+ V A+N G SD +
Sbjct: 30754 WITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFG--ISDPLE 30811
Query: 214 FDPVYKVKPNPPHNLSVINSEELSSILK----LTWTNP-SIKSVIILKYNIQYRTKDAST 268
V +K +P ++++ K + W P S I Y ++ R K +
Sbjct: 30812 VSSVVIIK-SPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNK 30870
Query: 269 WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSK 328
W + E+ T F+V++L EY FR++C G+ WS+ SE + D P +
Sbjct: 30871 WISVTTEEIRET--VFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPIT--PKSDVPIQ 30926
Query: 329 APSF 332
AP F
Sbjct: 30927 APHF 30930
Score = 42.7 bits (99), Expect = 0.002
Identities = 94/374 (25%), Positives = 139/374 (37%), Gaps = 63/374 (16%)
Query: 215 DPVYKVKP-NPPHNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQI 272
+PV + P +PP VIN S + L WT P L Y ++ R + +W +
Sbjct: 20266 EPVVALDPIDPPGKPEVINITRNS--VTLIWTEPKYDGGHKLTGYIVEKRDLPSKSWMKA 20323
Query: 273 PPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSF 332
+ +FTV DL +Y FRIR ++ G S SE I +D +AP+
Sbjct: 20324 NHVNVPEC--AFTVTDLVEGGKYEFRIRA--KNTAGAISAPSESTETIICKDE-YEAPTI 20378
Query: 333 WYKIDPSHTQGYRTVQLVWKTLPPFEANG-KILDYEVTLTRWKSHLQNYTVNATKLTVNL 391
+DP+ G L K N IL + + W + + +T +
Sbjct: 20379 --VLDPTIKDG-----LTIKAGDTIVLNAISILGKPLPKSSWSK--AGKDIRPSDIT-QI 20428
Query: 392 TNDRYLATLTVRNLVGKSDAAVLTIPACDFQATH------PVMDLKAFP--------KDN 437
T+ + LT++ K DA TI A + T V+D+ P
Sbjct: 20429 TSTPTSSMLTIKYATRK-DAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAE 20487
Query: 438 MLWVEWTTPRES----VKKYILE--------WCVLSDKAPCITDWQQEDGTVHRTYLRGN 485
+ WT P E +K YILE W V+S+ Q V ++GN
Sbjct: 20488 KATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDI-------QSCRHVATKLIQGN 20540
Query: 486 LAESKCYLITVTPVYADGPGSP---ESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQL 542
Y+ V+ V G G P E +K + PP V KN A + W +
Sbjct: 20541 E-----YIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTATVSWKR- 20594
Query: 543 PVDVQNGFIRNYTI 556
PVD I Y +
Sbjct: 20595 PVDDGGSEITGYHV 20608
Score = 42.4 bits (98), Expect = 0.002
Identities = 57/236 (24%), Positives = 88/236 (37%), Gaps = 32/236 (13%)
Query: 150 RETHLETNFTLKSEWATH-----KFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEA---- 200
RE H++ TL+ K K RD PT +D + V +E+ A
Sbjct: 17226 REQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGS-KLEIRNAAHEDG 17284
Query: 201 -------ENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNP-SIKSV 252
EN G T ++ + KP PP +L V SE LTW P
Sbjct: 17285 GIYSLTVENPAGSKT---VSVKVLVLDKPGPPRDLEV--SEIRKDSCYLTWKEPLDDGGS 17339
Query: 253 IILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSD 312
+I Y ++ R ++ WS P S + S + L +Y+FR+ + G+G + +
Sbjct: 17340 VITNYVVERRDVASAQWS---PLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVE 17396
Query: 313 WSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEV 368
+ + P P + +D T+ V LVW P + I Y V
Sbjct: 17397 TPKPIKALD-PLHPPGPPKDLHHVDVDKTE----VSLVWNK-PDRDGGSPITGYLV 17446
Score = 42.0 bits (97), Expect = 0.003
Identities = 83/409 (20%), Positives = 149/409 (36%), Gaps = 58/409 (14%)
Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIKS-VIILKYNIQYRTKDASTWSQIPPEDTAST 280
P PP + + +S + S + L W+ P + Y ++ R + W+ + + T
Sbjct: 27167 PGPPAKIRIADSTKSS--ITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRT 27224
Query: 281 RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSH 340
+ + V +LKP Y FR+ + G+G + +E + P +
Sbjct: 27225 -TEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIA 27283
Query: 341 TQGYRTVQLV-WKTLPPFEANGKILDYEVTLTRWKSHLQN------YTVNATKLTVNLT- 392
G L+ +K PP T+T W+ +N Y++ T + LT
Sbjct: 27284 KAGEDVQVLIPFKGRPP-----------PTVT-WRKDEKNLGSDARYSIENTDSSSLLTI 27331
Query: 393 -----NDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTP- 446
ND LT+ N VG+ ++ +++ D A + +K + + + W P
Sbjct: 27332 PQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGTVTLL-WDPPL 27390
Query: 447 ---RESVKKYILE--------WCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLIT 495
+ Y++E W V+S K T ++ D L+E +
Sbjct: 27391 IDGGSPIINYVIEKRDATKRTWSVVSHKCSS-TSFKLID-----------LSEKTPFFFR 27438
Query: 496 VTPVYADGPGSPESIKAYLKQAP-PSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNY 554
V G G P +K A P+ + K K +L W + D G +
Sbjct: 27439 VLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSWTK--PDFDGGSVITE 27496
Query: 555 TIFYRTIIGNETAVNVDSSHT-EYTLSSLTSDTLYMVRMAAYTDEGGKD 602
+ R G +T + S T E +S L ++ R+ A ++G D
Sbjct: 27497 YVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSD 27545
Score = 41.2 bits (95), Expect = 0.004
Identities = 48/195 (24%), Positives = 73/195 (37%), Gaps = 23/195 (11%)
Query: 125 PPEKPKNLSCIVNEGKK-MRCEW-----DGGRET---HLETNFTLKSEWATHKFADCKAK 175
PPE P N +++ K + W DGG ++E T +W H
Sbjct: 30328 PPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTT 30387
Query: 176 RDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKV---KPNPPHNLSVIN 232
T T D + + A+N +G + + V K KP+ P L +++
Sbjct: 30388 MYTVTGLVPD------AEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILS 30441
Query: 233 SEELSSILKLTWTNPSIKS-VIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKP 291
+ S + L W P IL Y ++YR S W + E + FT+ L
Sbjct: 30442 ISKDS--VTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQ--FTIGGLLE 30497
Query: 292 FTEYVFRIRCMKEDG 306
TEY FR+ E G
Sbjct: 30498 ATEYEFRVFAENETG 30512
Score = 40.8 bits (94), Expect = 0.006
Identities = 27/113 (23%), Positives = 50/113 (44%), Gaps = 5/113 (4%)
Query: 215 DPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILK-YNIQYRTKDASTWSQIP 273
DP++ P PP V ++ S + L W P+ +K Y ++ + + + W ++
Sbjct: 15700 DPIFP--PGPPSCPEV--KDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVN 15755
Query: 274 PEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRP 326
D T V +LK +Y FR++ + E G+ SD + E ++ P
Sbjct: 15756 EPDKLITTCECVVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEP 15808
Score = 40.8 bits (94), Expect = 0.006
Identities = 105/493 (21%), Positives = 184/493 (37%), Gaps = 68/493 (13%)
Query: 147 DGGRETHLETNFTL-KSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALG 205
DGG E TN+ + K E + +A A TSC+V+ + + + AEN G
Sbjct: 19415 DGGSEI---TNYIVDKRETSRPNWAQVSATVPI-TSCSVE-KLIEGHEYQFRICAENKYG 19469
Query: 206 KVTSDHINFDPVYKVKP-NPPHNLSV-INSEELSSILKLTWTNPSIKSVI-ILKYNIQYR 262
D + +P P +PP + S + ++W P+ I Y ++ R
Sbjct: 19470 --VGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKR 19527
Query: 263 TKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITY 322
A W+++ + T L+ TEY FR+ + + G G SD + +A+
Sbjct: 19528 ETQAVNWTKVNRKPIIERTLKAT--GLQEGTEYEFRVTAINKAGPGKPSD-ASKAAYARD 19584
Query: 323 EDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSH------ 376
P P+F D + + +V L W P ++ I+ Y V + R S
Sbjct: 19585 PQYPPGPPAFPKVYDTTRS----SVSLSWGK-PAYDGGSPIIGYLVEVKRADSDNWVRCN 19639
Query: 377 -LQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPK 435
QN ++T + + +Y + N +G SD + +P K +PK
Sbjct: 19640 LPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPS--DVPD------------KHYPK 19685
Query: 436 DNMLWVEWTTPRESVKKYILE-------WCVLSDKAPCITDWQQED------------GT 476
D ++ E + K IL + + + P W + + T
Sbjct: 19686 DILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKST 19745
Query: 477 VHRTYLR---GNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKN 533
T+LR N ++ Y++T+ + G E P V K++ K+
Sbjct: 19746 DFDTFLRCENVNKYDAGKYILTL----ENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKD 19801
Query: 534 EAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNE-TAVNVDSSHTEYTLSSLTSDTLYMVRM 592
A + W+ +D + I NY + R + V + S T + +++L Y R+
Sbjct: 19802 SAYVTWEPPIIDGGSPII-NYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRV 19860
Query: 593 AAYTDEGGKDGPE 605
A + G D E
Sbjct: 19861 FAENEYGIGDPGE 19873
Score = 39.3 bits (90), Expect = 0.017
Identities = 58/237 (24%), Positives = 95/237 (40%), Gaps = 30/237 (12%)
Query: 144 CEW-----DGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVW- 197
C+W DGG E N+TL+ + T ++ T C YS + + +
Sbjct: 14820 CKWEPPLDDGGSEI---INYTLEKKDKTKPDSEWIVVTSTLRHCK--YSVTKLIEGKEYL 14874
Query: 198 --VEAENALGK----VTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKS 251
V AEN G V+ + DP P+ P V + S ++K W P
Sbjct: 14875 FRVRAENRFGPGPPCVSKPLVAKDPFGP--PDAPDKPIVEDVTSNSMLVK--WNEPKDNG 14930
Query: 252 VIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWS 311
IL Y ++ R +++ WS++ + +++ V L YVFR+ G G +S
Sbjct: 14931 SPILGYWLEKREVNSTHWSRVNKSLLNALKAN--VDGLLEGLTYVFRVCAENAAGPGKFS 14988
Query: 312 DWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEV 368
S+ + ++ P D S T T++L W+ P F G+I+ Y V
Sbjct: 14989 PPSDPKT--AHDPISPPGPPIPRVTDTSST----TIELEWEP-PAFNGGGEIVGYFV 15038
Score = 38.5 bits (88), Expect = 0.029
Identities = 110/488 (22%), Positives = 175/488 (35%), Gaps = 72/488 (14%)
Query: 147 DGGRETHLETNFTL-KSEWATHKFADC-KAKRDTPTSCTVDYSTVYFVNIEVWVEAENAL 204
DGG E TN+ L K + +K+ C A + T T + + + V AEN
Sbjct: 20103 DGGSEI---TNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYT---FRVSAENKY 20156
Query: 205 GKVTSDHINFDPVYKVKP------NPPHNLSVINSEELSSILKLTWTNPS-IKSVIILKY 257
G + + +P+ P PP N+ + + +S LTWT+P I Y
Sbjct: 20157 G--VGEGLKSEPIVARHPFDVPDAPPPPNIVDVRHDSVS----LTWTDPKKTGGSPITGY 20210
Query: 258 NIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEA 317
+++++ +++ W + T F V L EY FR+ + G G S SE
Sbjct: 20211 HLEFKERNSLLWKRA--NKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPV 20268
Query: 318 SGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRW--KS 375
+ D P K +V L+W T P ++ K+ Y V KS
Sbjct: 20269 VALDPIDPPGKPEVI--------NITRNSVTLIW-TEPKYDGGHKLTGYIVEKRDLPSKS 20319
Query: 376 HLQNYTVNATKLTVNLTN----DRYLATLTVRNLVGKSDA---AVLTIPACDFQATHPVM 428
++ VN + +T+ +Y + +N G A + TI C + P +
Sbjct: 20320 WMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETI-ICKDEYEAPTI 20378
Query: 429 DLKAFPKDNMLWVEWTT-------------PRESVKKYILEWCVLSDKAPCITDWQQEDG 475
L KD + T P+ S K + K +D Q
Sbjct: 20379 VLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSK--------AGKDIRPSDITQITS 20430
Query: 476 TVHRTYLRGNLAESKC---YLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGK 532
T + L A K Y IT T + E +K + P GP V V
Sbjct: 20431 TPTSSMLTIKYATRKDAGEYTITATNPFGT---KVEHVKVTVLDVPGPPGP-VEISNVSA 20486
Query: 533 NEAVLEWDQLPVDVQNGFIRNYTIFYR-TIIGNETAVNVDSSHTEYTLSSLTSDTLYMVR 591
+A L W P++ I++Y + R T T V+ D + + L Y+ R
Sbjct: 20487 EKATLTWTP-PLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFR 20545
Query: 592 MAAYTDEG 599
++A G
Sbjct: 20546 VSAVNHYG 20553
Score = 38.1 bits (87), Expect = 0.038
Identities = 78/364 (21%), Positives = 137/364 (37%), Gaps = 31/364 (8%)
Query: 195 EVWVEAENALGKVTSDHINFDPVYK----VKPNPPHNLSVINSEELSSILKLTWTNPSIK 250
E V AEN +G + PV+ KP+PP N I++ + + LTW P
Sbjct: 17083 EFRVSAENEIG-IGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTT--CNSVDLTWQPPRHD 17139
Query: 251 SVI-ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGY 309
IL Y ++Y+ W + + + + V L+ Y FR+ + G+
Sbjct: 17140 GGSKILGYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGE-- 17197
Query: 310 WSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRT-----VQLVWKTLPPFEANGKIL 364
SD + + +DR + P + + Q + + + K +P + K
Sbjct: 17198 -SDPAHVPEPVLVKDR-LEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKE 17255
Query: 365 DYEVTLTRWKSHLQNYTVNATKLTVN--LTNDRYLATLTVRNLVGKSDAAVLTIPACDFQ 422
D + K+ + + T +KL + D + +LTV N G +V + D
Sbjct: 17256 DRDAPT---KARI-DVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVL-VLDKP 17310
Query: 423 ATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGT-VHRTY 481
+++ KD+ ++ W P + I + V+ + W T +++
Sbjct: 17311 GPPRDLEVSEIRKDS-CYLTWKEPLDDGGSVITNY-VVERRDVASAQWSPLSATSKKKSH 17368
Query: 482 LRGNLAESKCYLITVTP--VYADGP--GSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVL 537
+L E YL V Y GP +P+ IKA PP + V K E L
Sbjct: 17369 FAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSL 17428
Query: 538 EWDQ 541
W++
Sbjct: 17429 VWNK 17432
Score = 37.7 bits (86), Expect = 0.050
Identities = 67/273 (24%), Positives = 105/273 (38%), Gaps = 38/273 (13%)
Query: 356 PFEANGKILDYEVTLTRWKSHLQ------NYTVNATKLTVNLTNDRYLATLTVRNLVGKS 409
P E G +DY + R SHL + + K+T L + Y+ +T N G
Sbjct: 25907 PQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVG 25966
Query: 410 DAAV-LTIPACD-FQATHPV--MDLKAFPKDNMLWVEWTTPRES----VKKYILE----- 456
+ + I A D F P +++ + K++M W+ P + YI+E
Sbjct: 25967 EPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLC-WSRPESDGGSEISGYIIERREKN 26025
Query: 457 ---WCVLSDKAPCITDWQQEDGTVHRTYLR-GNLAESKCYLITVTPVYADGPGSP--ESI 510
W V +K P D V T LR G E + Y + SP +
Sbjct: 26026 SLRW-VRVNKKPVY------DLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAE 26078
Query: 511 KAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNV 570
+PPSK V + GK + W + P+ I YT+ Y+ + ++
Sbjct: 26079 DPVFLPSPPSKPKIVDS---GKTTITIAWVK-PLFDGGAPITGYTVEYKKSDDTDWKTSI 26134
Query: 571 DSSH-TEYTLSSLTSDTLYMVRMAAYTDEGGKD 602
S TEYT+S LT+ Y+ R+ + G D
Sbjct: 26135 QSLRGTEYTISGLTTGAEYVFRVKSVNKVGASD 26167
Score = 36.6 bits (83), Expect = 0.11
Identities = 79/338 (23%), Positives = 118/338 (34%), Gaps = 36/338 (10%)
Query: 195 EVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVII 254
E +E +N G TS+ I + KP PP I+ + +SI ++W P +
Sbjct: 29808 EYTLELKNVTG-TTSETIKV--IILDKPGPPTGPIKIDEIDATSIT-ISWEPPELDGGAP 29863
Query: 255 LK-YNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYW--S 311
L Y ++ R W P + TRS+F L EYVFR+ G G + S
Sbjct: 29864 LSGYVVEQRDAHRPGWL---PVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQS 29920
Query: 312 DWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANG-KILDY---- 366
+ E S I P F D + L W PP + G ++ Y
Sbjct: 29921 EVIECRSSIRIPGPPETLQIFDVSRD--------GMTLTW--YPPEDDGGSQVTGYIVER 29970
Query: 367 -EVTLTRW----KSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDF 421
EV RW K + +T LT L + + + R GK I A D
Sbjct: 29971 KEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARG-SGKPSRPSKPIVAMDP 30029
Query: 422 QAT--HPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQ--EDGTV 477
A P + + W+ P + + + + K +W + T
Sbjct: 30030 IAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVD-QHEWTKCNTTPTK 30088
Query: 478 HRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLK 515
R Y +L + Y V A GPG P + +K
Sbjct: 30089 IREYTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVK 30126
Score = 35.4 bits (80), Expect = 0.25
Identities = 77/319 (24%), Positives = 122/319 (38%), Gaps = 54/319 (16%)
Query: 221 KPNPPHNLSVINSEELSSI-LKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTA 278
+P PP + I E +S+ + L+W P I Y I+ R + TW + E
Sbjct: 16216 RPGPP--VGPIKFESVSADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVSSEPKE 16273
Query: 279 STRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYE-----DRPSKAPSFW 333
T +T+ L EYVFRI + G G D E + + D+P+ +
Sbjct: 16274 CT---YTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVS---- 16326
Query: 334 YKIDPSHTQGYRTVQLVWKTLPPFEANGKILDY-----EVTLTRWK----SHLQNYTVNA 384
S T+ TV W+ P ++ + Y + T RWK ++ T+
Sbjct: 16327 -----SVTRNSMTVN--WEE-PEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMTLGV 16378
Query: 385 T-KLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDL-KAFPK-----DN 437
+ K+T + Y + N G A++ + PA A P+ FPK +
Sbjct: 16379 SYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPA---TARDPIAPPGPPFPKVTDWTKS 16435
Query: 438 MLWVEWTTPRE----SVKKYILEWCVLSDKAPCITDWQQ-EDGTVHRTYL-RGNLAESKC 491
+EW+ P + V YI+E+ K +W++ +D V T L L E
Sbjct: 16436 SADLEWSPPLKDGGSKVTGYIVEY-----KEEGKEEWEKGKDKEVRGTKLVVTGLKEGAF 16490
Query: 492 YLITVTPVYADGPGSPESI 510
Y V V G G P +
Sbjct: 16491 YKFRVRAVNIAGIGEPGEV 16509
Score = 35.4 bits (80), Expect = 0.25
Identities = 61/273 (22%), Positives = 93/273 (34%), Gaps = 24/273 (8%)
Query: 349 LVWKTLPPFEANG-KILDY-----EVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTV 402
L W+ PP E G +I +Y E + W + + + + Y +
Sbjct: 19407 LSWE--PPLEDGGSEITNYIVDKRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFRICA 19464
Query: 403 RNLVGKSDAAVLTIPACDFQATHPVMD-----LKAFPKDNMLWVEWTTPRESVKKYILEW 457
N G D V T PA P + KD+M V W P + I +
Sbjct: 19465 ENKYGVGDP-VFTEPAIAKNPYDPPGRCDPPVISNITKDHMT-VSWKPPADDGGSPITGY 19522
Query: 458 CVLSDKAPCITDWQQEDGT--VHRTYLRGNLAESKCYLITVTPVYADGPGSPE--SIKAY 513
+L + +W + + + RT L E Y VT + GPG P S AY
Sbjct: 19523 -LLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAY 19581
Query: 514 LK--QAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVD 571
+ Q PP + ++ L W + D + I R N N+
Sbjct: 19582 ARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLP 19641
Query: 572 SS--HTEYTLSSLTSDTLYMVRMAAYTDEGGKD 602
+ T + ++ L DT Y R+ A G D
Sbjct: 19642 QNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSD 19674
Score = 35.0 bits (79), Expect = 0.32
Identities = 40/140 (28%), Positives = 56/140 (40%), Gaps = 17/140 (12%)
Query: 198 VEAENALGKVTSDHINFDPVYKVKP--------NPPHNLSVINSEELSSILKLTWTNPSI 249
V AEN G ++ + +PV P NPP L V S + L+W+ P
Sbjct: 30302 VSAENQFG-ISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSS-----VSLSWSRPKD 30355
Query: 250 KSVI-ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
+ Y I+ K+ ST + T T + +TV L P EY FRI + G
Sbjct: 30356 DGGSRVTGYYIE--RKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLS 30413
Query: 309 YWSDWSEEASGITYEDRPSK 328
S SE D+PS+
Sbjct: 30414 ETSPASEPVVCKDPFDKPSQ 30433
Score = 33.9 bits (76), Expect = 0.72
Identities = 84/373 (22%), Positives = 131/373 (35%), Gaps = 54/373 (14%)
Query: 198 VEAENALGKVTSDHINFDPVYKVKP----NPPHNLSVINSEELSSILKLTWTNPSIKS-V 252
V+AEN +G + + PV P PP N V+++ + S + L W P
Sbjct: 18470 VKAENEIG-IGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHS--ITLGWGKPVYDGGA 18526
Query: 253 IILKYNIQYRTK--DAST---WSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGK 307
I+ Y ++ R K DAS W + R FTV L EY FR+ + G
Sbjct: 18527 PIIGYVVEMRPKIADASPDEGWKRCNAA-AQLVRKEFTVTSLDENQEYEFRVCAQNQVGI 18585
Query: 308 GYWSDWSEEASGITYEDRP---------------SKAPSFWYKIDPSHTQGYRTVQLVWK 352
G ++ E + P + P + I +G ++ W+
Sbjct: 18586 GRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRLFAI----VRGRPAPKVTWR 18641
Query: 353 TLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAA 412
+ + + +V L + L N+T+ +D +LT+ N G+ A
Sbjct: 18642 KV---GIDNVVRKGQVDLVDTMAFL--VIPNSTR------DDSGKYSLTLVNPAGEK-AV 18689
Query: 413 VLTIPACDFQATHPVMDLKAFP-KDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQ 471
+ + D PV DLK V W P + + V +A T W
Sbjct: 18690 FVNVRVLD--TPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKT-WS 18746
Query: 472 QEDGTVHRTYLR-GNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGP----TVR 526
V +T NL Y VT V GPG P + + + P P +
Sbjct: 18747 TVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLE 18806
Query: 527 TKKVGKNEAVLEW 539
++ KN A L W
Sbjct: 18807 VTEMTKNSATLAW 18819
Score = 33.1 bits (74), Expect = 1.2
Identities = 87/413 (21%), Positives = 149/413 (36%), Gaps = 50/413 (12%)
Query: 135 IVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNI 194
+VN G+ R E D + L T L+ + + A C+ K + + +
Sbjct: 23636 VVNAGETFRLEADVHGKP-LPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGG 23694
Query: 195 EVWVEAENALGKVTSDHINFDPVYKV--KPNPPHN---LSVINSEELSSILKLTWTNP-S 248
+ + A N G + F KV +P PP ++ + SE+ S LTW+ P
Sbjct: 23695 QYILRASNVAGSKS-----FPVNVKVLDRPGPPEGPVQVTGVTSEKCS----LTWSPPLQ 23745
Query: 249 IKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
I Y ++ R W+ + E + S V L EYVFRI + + G G
Sbjct: 23746 DGGSDISHYVVEKRETSRLAWTVVASEVVTN---SLKVTKLLEGNEYVFRIMAVNKYGVG 23802
Query: 309 YWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEV 368
S P P ++ ++ ++ + W P + +I+ Y +
Sbjct: 23803 -----EPLESAPVLMKNPFVLPGPPKSLEVTNI-AKDSMTVCWNR-PDSDGGSEIIGY-I 23854
Query: 369 TLTRWKSHLQNYTVNATKLT------VNLTND-RYLATLTVRNL--VGKSDAAVLTIPAC 419
R +S ++ N ++T LT D Y ++ N VG+ A + AC
Sbjct: 23855 VEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKAC 23914
Query: 420 D--FQATHPVMDLKAFPKDNMLWVEWTTP----RESVKKYILEWCVLSDKAPCITDWQ-- 471
D F+ P N + + W P + Y++E C ++ +WQ
Sbjct: 23915 DPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEE-----EWQIV 23969
Query: 472 -QEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGP 523
+ G + L E + Y I V + G G S+ +K + P
Sbjct: 23970 TPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAP 24022
Score = 32.7 bits (73), Expect = 1.6
Identities = 32/120 (26%), Positives = 50/120 (41%), Gaps = 11/120 (9%)
Query: 195 EVWVEAENALG-----KVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSI 249
E V AEN G + + + D Y P PP N V ++ + S+ L W P
Sbjct: 20643 EFRVSAENRAGIGPPSEASDSVLMKDAAYP--PGPPSNPHVTDTTKKSA--SLAWGKPHY 20698
Query: 250 KSVI-ILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKG 308
+ I Y ++++ W + TA + F V DL+ +Y FRI + + G G
Sbjct: 20699 DGGLEITGYVVEHQKVGDEAWIK-DTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVG 20757
Score = 32.3 bits (72), Expect = 2.1
Identities = 30/104 (28%), Positives = 45/104 (43%), Gaps = 9/104 (8%)
Query: 222 PNPPHNLSVINSEELSSILKLTWTNPSIK-SVIILKYNIQYRTKDASTWSQIPPEDTAST 280
P+PP L VIN + ++ LK WT P I Y ++ R W + DT
Sbjct: 14084 PSPPRWLEVINITKNTADLK--WTVPEKDGGSPITNYIVEKRDVRRKGWQTV---DTTVK 14138
Query: 281 RSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYED 324
+ TV L + YVFR+ G+ SD++E + +D
Sbjct: 14139 DTKCTVTPLTEGSLYVFRVAAENAIGQ---SDYTEIEDSVLAKD 14179
Score = 32.3 bits (72), Expect = 2.1
Identities = 29/113 (25%), Positives = 45/113 (39%), Gaps = 8/113 (7%)
Query: 198 VEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILK 256
+ N +G+ T+ + + V KP+PP + SI L+W P I
Sbjct: 23302 ITVANVVGQKTA---SIEIVTLDKPDPPKGPVKFDDVSAESIT-LSWNPPLYTGGCQITN 23357
Query: 257 YNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGY 309
Y +Q R + W + R++ V LK TEY FRI G+ +
Sbjct: 23358 YIVQKRDTTTTVWDVV---SATVARTTLKVTKLKTGTEYQFRIFAENRYGQSF 23407
Score = 31.2 bits (69), Expect = 4.6
Identities = 31/149 (20%), Positives = 57/149 (38%), Gaps = 13/149 (8%)
Query: 221 KPNPPHNLSVINSEELSSILKLTWTNPSIKSVI-ILKYNIQYRTKDASTWSQIPPEDTAS 279
+P PP + + E + ++W P I Y ++ + ++TW + A
Sbjct: 25487 RPGPPGPIRI--DEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIV---SQAV 25541
Query: 280 TRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPS 339
R+S + L +EY FR+ GK +S+ S A Y P P P
Sbjct: 25542 ARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESS--AVVAEYPFSPPGPPG-----TPK 25594
Query: 340 HTQGYRTVQLVWKTLPPFEANGKILDYEV 368
++ LV +P + +++ Y +
Sbjct: 25595 VVHATKSTMLVTWQVPVNDGGSRVIGYHL 25623
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,263,332
Number of Sequences: 37866
Number of extensions: 1769093
Number of successful extensions: 6217
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 145
Number of HSP's that attempted gapping in prelim test: 5218
Number of HSP's gapped (non-prelim): 854
length of query: 918
length of database: 18,247,518
effective HSP length: 111
effective length of query: 807
effective length of database: 14,044,392
effective search space: 11333824344
effective search space used: 11333824344
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.