Search of human proteins with 27765085

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27765085 calpastatin isoform b [Homo sapiens]
         (686 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|109637763 calpastatin isoform h [Homo sapiens]                    1360   0.0  
gi|27765085 calpastatin isoform b [Homo sapiens]                     1360   0.0  
gi|109637765 calpastatin isoform i [Homo sapiens]                    1347   0.0  
gi|109637753 calpastatin isoform a [Homo sapiens]                    1347   0.0  
gi|109637769 calpastatin isoform k [Homo sapiens]                    1324   0.0  
gi|109637757 calpastatin isoform e [Homo sapiens]                    1324   0.0  
gi|109637767 calpastatin isoform j [Homo sapiens]                    1310   0.0  
gi|109637759 calpastatin isoform f [Homo sapiens]                    1310   0.0  
gi|109637761 calpastatin isoform g [Homo sapiens]                    1300   0.0  
gi|109637771 calpastatin isoform l [Homo sapiens]                    1274   0.0  
gi|27765087 calpastatin isoform c [Homo sapiens]                      781   0.0  
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     91   3e-18
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    67   5e-11
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    67   5e-11
gi|150170670 piccolo isoform 2 [Homo sapiens]                          65   2e-10
gi|150378539 piccolo isoform 1 [Homo sapiens]                          65   2e-10
gi|104526627 triadin [Homo sapiens]                                    64   6e-10
gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sa...    61   3e-09
gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sa...    61   3e-09
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]                    61   3e-09
gi|109637791 transcription factor-like nuclear regulator [Homo s...    60   5e-09
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    59   2e-08
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   58   3e-08
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   58   3e-08
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   58   3e-08
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    58   3e-08
gi|153945728 microtubule-associated protein 1B [Homo sapiens]          58   3e-08
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    57   4e-08
gi|151301171 RNA polymerase II transcription factor TAFII140 [Ho...    57   6e-08
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]    56   1e-07

>gi|109637763 calpastatin isoform h [Homo sapiens]
          Length = 769

 Score = 1360 bits (3519), Expect = 0.0
 Identities = 686/686 (100%), Positives = 686/686 (100%)

Query: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60
           MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK
Sbjct: 84  MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 143

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 144 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 203

Query: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 204 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 263

Query: 181 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 240
           PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 264 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 323

Query: 241 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 300
           QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 324 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 383

Query: 301 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 360
           EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 384 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 443

Query: 361 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 420
           EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 444 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 503

Query: 421 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 480
           KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 504 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 563

Query: 481 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 540
           LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 564 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 623

Query: 541 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 600
           SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 624 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 683

Query: 601 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 660
           DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 684 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 743

Query: 661 SKAPKNGGKAKDSAKTTEETSKPKDD 686
           SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 744 SKAPKNGGKAKDSAKTTEETSKPKDD 769



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 87/359 (24%), Positives = 148/359 (41%), Gaps = 17/359 (4%)

Query: 331 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 388
           + +P +KP   PR         + +    +  E PSKP EK    +  A +  S    RT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 389 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 448
                 SA    A+   T    ++        K E + +     +  V EK  +E + K 
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120

Query: 449 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 508
             + +++P         D   K  + + +++Q    S +          +G ++ + +  
Sbjct: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180

Query: 509 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKP 568
              K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +EN  
Sbjct: 181 ISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEENTT 237

Query: 569 ME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 627
               +V +   + + ++LG+R+ TIPP+YR LL    ++    PP     DS KP    D
Sbjct: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPIGPDD 291

Query: 628 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 686
            IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K + D
Sbjct: 292 AIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEKD 345


>gi|27765085 calpastatin isoform b [Homo sapiens]
          Length = 686

 Score = 1360 bits (3519), Expect = 0.0
 Identities = 686/686 (100%), Positives = 686/686 (100%)

Query: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60
           MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK
Sbjct: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120

Query: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180

Query: 181 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 240
           PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 181 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 240

Query: 241 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 300
           QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 241 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 300

Query: 301 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 360
           EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 301 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 360

Query: 361 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 420
           EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 361 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 420

Query: 421 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 480
           KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 421 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 480

Query: 481 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 540
           LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 481 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 540

Query: 541 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 600
           SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 541 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 600

Query: 601 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 660
           DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 601 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 660

Query: 661 SKAPKNGGKAKDSAKTTEETSKPKDD 686
           SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 661 SKAPKNGGKAKDSAKTTEETSKPKDD 686


>gi|109637765 calpastatin isoform i [Homo sapiens]
          Length = 708

 Score = 1347 bits (3486), Expect = 0.0
 Identities = 686/708 (96%), Positives = 686/708 (96%), Gaps = 22/708 (3%)

Query: 1   MNPTETKA----------------------VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 38
           MNPTETKA                      VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH
Sbjct: 1   MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60

Query: 39  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 98
           TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
Sbjct: 61  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 120

Query: 99  SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 158
           SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
Sbjct: 121 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 180

Query: 159 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 218
           EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT
Sbjct: 181 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 240

Query: 219 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 278
           CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
Sbjct: 241 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 300

Query: 279 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 338
           RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
Sbjct: 301 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 360

Query: 339 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 398
           KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
Sbjct: 361 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420

Query: 399 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 458
           EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
Sbjct: 421 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480

Query: 459 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 518
           YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
Sbjct: 481 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 540

Query: 519 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 578
           EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
Sbjct: 541 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 600

Query: 579 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 638
           AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
Sbjct: 601 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 660

Query: 639 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 686
           CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 661 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708


>gi|109637753 calpastatin isoform a [Homo sapiens]
          Length = 791

 Score = 1347 bits (3486), Expect = 0.0
 Identities = 686/708 (96%), Positives = 686/708 (96%), Gaps = 22/708 (3%)

Query: 1   MNPTETKA----------------------VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 38
           MNPTETKA                      VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH
Sbjct: 84  MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 143

Query: 39  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 98
           TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
Sbjct: 144 TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 203

Query: 99  SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 158
           SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
Sbjct: 204 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 263

Query: 159 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 218
           EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT
Sbjct: 264 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 323

Query: 219 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 278
           CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
Sbjct: 324 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 383

Query: 279 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 338
           RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
Sbjct: 384 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 443

Query: 339 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 398
           KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
Sbjct: 444 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 503

Query: 399 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 458
           EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
Sbjct: 504 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 563

Query: 459 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 518
           YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
Sbjct: 564 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 623

Query: 519 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 578
           EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
Sbjct: 624 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 683

Query: 579 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 638
           AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
Sbjct: 684 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 743

Query: 639 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 686
           CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 744 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 791



 Score =  221 bits (564), Expect = 1e-57
 Identities = 196/668 (29%), Positives = 315/668 (47%), Gaps = 71/668 (10%)

Query: 59  KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPV 118
           + A +R   +  SEK++E  +KP +   +  +  A +    G     +        A  V
Sbjct: 16  RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASL----GSSQSSRTYAGGTASATKV 71

Query: 119 ESKPDKPSGKSGMDAALDDLI---DTLGGP----EETEEENTTYTGPEVSDPMSSTYIEE 171
            +     S  S M+      I     + GP    ++  ++    T PE     +   +  
Sbjct: 72  SASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVH 131

Query: 172 LGKREVTIPPKYRE--LLAKKEGITG-----------------PPADSSKP-IGPDDAID 211
             K +   P ++ E   L K+   TG                 P   S++P   P D I 
Sbjct: 132 EKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMIS 191

Query: 212 ALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEA 271
           A   +   G    +GK  +K++  +        ++  A P + K  K    +  D AL+ 
Sbjct: 192 A-GGESVAGITAISGKPGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDD 242

Query: 272 LSASL-GTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPL 330
           L  +L G  + E E    +  EV +  +    +E+ G+ + TIP +YR +    K+G  +
Sbjct: 243 LIDTLGGPEETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYR-ELLAKKEG--I 298

Query: 331 LPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSM 390
              P +  KP    + ID LS DF        P+   +KTE+ ++      +E +   S 
Sbjct: 299 TGPPADSSKPIGPDDAIDALSSDFTCG----SPTAAGKKTEKEES------TEVLKAQSA 348

Query: 391 CSIQSAPP----EPATLKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDR 445
            +++SA P    +    K T+ D A+EAL+ SLG ++A+PE D + + +  + KAKEE  
Sbjct: 349 GTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKL 408

Query: 446 EKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ---- 501
           EK GE +ETIP +YRL+   DKDGKPLLP E +E+  P SE  L+D LSEDF   +    
Sbjct: 409 EKCGEDDETIPSEYRLKPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEK 467

Query: 502 -NASSLKFEDAKLA--AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQ 558
            +  + K E++K A  A +SE V +T   + Q+ APP   +      DDA++ L+DSLG+
Sbjct: 468 PSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGK 526

Query: 559 RQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSED 618
           ++ DP++ KP+ DKVKEKAK E R+KLGE+++TIPP+YR     +   KP+ P  K+S++
Sbjct: 527 KEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKE 584

Query: 619 SKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTE 678
              P  +   +DALS D     + +      AK     +   S+ P +  +A    + T 
Sbjct: 585 QLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTS 644

Query: 679 ETSKPKDD 686
           ++ K  DD
Sbjct: 645 QSDKDLDD 652



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 100/387 (25%), Positives = 162/387 (41%), Gaps = 51/387 (13%)

Query: 331 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 388
           + +P +KP   PR         + +    +  E PSKP EK    +  A +  S    RT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 389 SMCSIQSAPPEPATLKGTVPDDAV---EALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 445
                 SA    A+   T    ++   E  A  + ++   P    P   K K++A + + 
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPH--LPNKKKHKKQAVKTEP 118

Query: 446 EKLGEKEETIPPDYRLEEVKDKDGKP-------LLPKE----------SKEQLPPMSEDF 488
           EK  +  +       + E K ++GKP        LPK+          +K+ +   +E  
Sbjct: 119 EKKSQSTKLSV----VHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQ 174

Query: 489 LLDALSEDFSGPQNASSLKFEDAKLAAAIS--------EVVSQTPASTTQAGAPPRDTSQ 540
             +  +E  + PQ+  S   E      AIS        E  S TPA   ++  P + + +
Sbjct: 175 PSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGK 233

Query: 541 SDKDLDDALDKLSDSLGQRQPDPDENKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHL 599
           S   +D ALD L D+LG  +   +EN      +V +   + + ++LG+R+ TIPP+YR L
Sbjct: 234 S--GMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYREL 291

Query: 600 LDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAAS 659
           L    ++    PP     DS KP    D IDALS D  +C S T   + T K++  +   
Sbjct: 292 LAK--KEGITGPPA----DSSKPIGPDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLK 344

Query: 660 SSKAPKNGGKAKDSAKTTEETSKPKDD 686
           +  A    G  + +A   E+  K + D
Sbjct: 345 AQSA----GTVRSAAPPQEKKRKVEKD 367


>gi|109637769 calpastatin isoform k [Homo sapiens]
          Length = 673

 Score = 1324 bits (3427), Expect = 0.0
 Identities = 673/686 (98%), Positives = 673/686 (98%), Gaps = 13/686 (1%)

Query: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60
           MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK
Sbjct: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120

Query: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180

Query: 181 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 240
           PKYRELLAK             PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 181 PKYRELLAK-------------PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 227

Query: 241 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 300
           QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 228 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 287

Query: 301 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 360
           EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 288 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 347

Query: 361 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 420
           EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 348 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 407

Query: 421 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 480
           KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 408 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 467

Query: 481 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 540
           LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 468 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 527

Query: 541 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 600
           SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 528 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 587

Query: 601 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 660
           DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 588 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 647

Query: 661 SKAPKNGGKAKDSAKTTEETSKPKDD 686
           SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 648 SKAPKNGGKAKDSAKTTEETSKPKDD 673


>gi|109637757 calpastatin isoform e [Homo sapiens]
          Length = 756

 Score = 1324 bits (3427), Expect = 0.0
 Identities = 673/686 (98%), Positives = 673/686 (98%), Gaps = 13/686 (1%)

Query: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60
           MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK
Sbjct: 84  MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 143

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 144 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 203

Query: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 204 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 263

Query: 181 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 240
           PKYRELLAK             PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 264 PKYRELLAK-------------PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 310

Query: 241 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 300
           QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 311 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 370

Query: 301 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 360
           EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 371 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 430

Query: 361 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 420
           EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 431 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 490

Query: 421 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 480
           KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 491 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 550

Query: 481 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 540
           LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 551 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 610

Query: 541 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 600
           SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 611 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 670

Query: 601 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 660
           DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 671 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 730

Query: 661 SKAPKNGGKAKDSAKTTEETSKPKDD 686
           SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 731 SKAPKNGGKAKDSAKTTEETSKPKDD 756



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 83/359 (23%), Positives = 142/359 (39%), Gaps = 30/359 (8%)

Query: 331 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 388
           + +P +KP   PR         + +    +  E PSKP EK    +  A +  S    RT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 389 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 448
                 SA    A+   T    ++        K E + +     +  V EK  +E + K 
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120

Query: 449 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 508
             + +++P         D   K  + + +++Q    S +          +G ++ + +  
Sbjct: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180

Query: 509 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKP 568
              K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +EN  
Sbjct: 181 ISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEENTT 237

Query: 569 ME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 627
               +V +   + + ++LG+R+ TIPP+YR LL                    KP    D
Sbjct: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELL-------------------AKPIGPDD 278

Query: 628 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 686
            IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K + D
Sbjct: 279 AIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEKD 332


>gi|109637767 calpastatin isoform j [Homo sapiens]
          Length = 667

 Score = 1310 bits (3390), Expect = 0.0
 Identities = 667/686 (97%), Positives = 667/686 (97%), Gaps = 19/686 (2%)

Query: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60
           MNPTETKAVKTEPEKKSQSTK                   PKSLPKQASDTGSNDAHNKK
Sbjct: 1   MNPTETKAVKTEPEKKSQSTK-------------------PKSLPKQASDTGSNDAHNKK 41

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 42  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 101

Query: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 102 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 161

Query: 181 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 240
           PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 162 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 221

Query: 241 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 300
           QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 222 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 281

Query: 301 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 360
           EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 282 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 341

Query: 361 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 420
           EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 342 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 401

Query: 421 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 480
           KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 402 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 461

Query: 481 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 540
           LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 462 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 521

Query: 541 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 600
           SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 522 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 581

Query: 601 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 660
           DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 582 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 641

Query: 661 SKAPKNGGKAKDSAKTTEETSKPKDD 686
           SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 642 SKAPKNGGKAKDSAKTTEETSKPKDD 667


>gi|109637759 calpastatin isoform f [Homo sapiens]
          Length = 750

 Score = 1310 bits (3390), Expect = 0.0
 Identities = 667/686 (97%), Positives = 667/686 (97%), Gaps = 19/686 (2%)

Query: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60
           MNPTETKAVKTEPEKKSQSTK                   PKSLPKQASDTGSNDAHNKK
Sbjct: 84  MNPTETKAVKTEPEKKSQSTK-------------------PKSLPKQASDTGSNDAHNKK 124

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 125 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 184

Query: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 185 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 244

Query: 181 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 240
           PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 245 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 304

Query: 241 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 300
           QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 305 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 364

Query: 301 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 360
           EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 365 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 424

Query: 361 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 420
           EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 425 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 484

Query: 421 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 480
           KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 485 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 544

Query: 481 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 540
           LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 545 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 604

Query: 541 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 600
           SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 605 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 664

Query: 601 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 660
           DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 665 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 724

Query: 661 SKAPKNGGKAKDSAKTTEETSKPKDD 686
           SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 725 SKAPKNGGKAKDSAKTTEETSKPKDD 750



 Score = 79.7 bits (195), Expect = 8e-15
 Identities = 88/362 (24%), Positives = 152/362 (41%), Gaps = 42/362 (11%)

Query: 331 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEK--TEESKAAAPAPVSEAVC 386
           + +P +KP   PR         + +    +  E PSKP EK  ++E KAA          
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAA---------- 50

Query: 387 RTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEA-DPEDGKPVMDKVKEKAKEEDR 445
                S+ S+        GT     V A + +  K  + +P + K V  + ++K++    
Sbjct: 51  -----SLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQ---- 101

Query: 446 EKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASS 505
                K +++P         D   K  + + +++Q    S +          +G ++ + 
Sbjct: 102 ---STKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 158

Query: 506 LKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDE 565
           +     K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +E
Sbjct: 159 ITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEE 215

Query: 566 NKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPAD 624
           N      +V +   + + ++LG+R+ TIPP+YR LL    ++    PP     DS KP  
Sbjct: 216 NTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPIG 269

Query: 625 DQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPK 684
             D IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K +
Sbjct: 270 PDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVE 324

Query: 685 DD 686
            D
Sbjct: 325 KD 326


>gi|109637761 calpastatin isoform g [Homo sapiens]
          Length = 772

 Score = 1300 bits (3364), Expect = 0.0
 Identities = 659/689 (95%), Positives = 667/689 (96%), Gaps = 3/689 (0%)

Query: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEK---KSQEGKPKEHTEPKSLPKQASDTGSNDAH 57
           MNPTETKA+    + +         H+K   K++  K  + T+PKSLPKQASDTGSNDAH
Sbjct: 84  MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAH 143

Query: 58  NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 117
           NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP
Sbjct: 144 NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 203

Query: 118 VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV 177
           VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV
Sbjct: 204 VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV 263

Query: 178 TIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 237
           TIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV
Sbjct: 264 TIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 323

Query: 238 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK 297
           LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK
Sbjct: 324 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK 383

Query: 298 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 357
           AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS
Sbjct: 384 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 443

Query: 358 ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD 417
           ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD
Sbjct: 444 ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD 503

Query: 418 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES 477
           SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES
Sbjct: 504 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES 563

Query: 478 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 537
           KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD
Sbjct: 564 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 623

Query: 538 TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR 597
           TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR
Sbjct: 624 TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR 683

Query: 598 HLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKA 657
           HLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKA
Sbjct: 684 HLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKA 743

Query: 658 ASSSKAPKNGGKAKDSAKTTEETSKPKDD 686
           ASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 744 ASSSKAPKNGGKAKDSAKTTEETSKPKDD 772



 Score =  224 bits (570), Expect = 3e-58
 Identities = 195/664 (29%), Positives = 315/664 (47%), Gaps = 82/664 (12%)

Query: 59  KKAVSRSAEQQPSEKSTEPKTKPQD-------------------MISAGGESVAGITAIS 99
           + A +R   +  SEK++E  +KP +                     + G  S   ++A S
Sbjct: 16  RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASS 75

Query: 100 GKPGDKKKEKKSLTPAVPVESK---PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 156
           G          + T A+PV  +   P  P+ K     A+           +TE E  + +
Sbjct: 76  GATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAV-----------KTEPEKKSQS 124

Query: 157 GPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP-IGPDDAIDALSS 215
               S P  ++   + G  +      + +    +     P   S++P   P D I A   
Sbjct: 125 TKPKSLPKQAS---DTGSNDA-----HNKKAVSRSAEQQPSEKSTEPKTKPQDMISA-GG 175

Query: 216 DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSAS 275
           +   G    +GK  +K++  +        ++  A P + K  K    +  D AL+ L  +
Sbjct: 176 ESVAGITAISGKPGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDDLIDT 227

Query: 276 L-GTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 334
           L G  + E E    +  EV +  +    +E+ G+ + TIP +YR +    K+G  +   P
Sbjct: 228 LGGPEETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYR-ELLAKKEG--ITGPP 283

Query: 335 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 394
            +  KP    + ID LS DF        P+   +KTE+ ++      +E +   S  +++
Sbjct: 284 ADSSKPIGPDDAIDALSSDFTCG----SPTAAGKKTEKEES------TEVLKAQSAGTVR 333

Query: 395 SAPP----EPATLKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLG 449
           SA P    +    K T+ D A+EAL+ SLG ++A+PE D + + +  + KAKEE  EK G
Sbjct: 334 SAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCG 393

Query: 450 EKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NAS 504
           E +ETIP +YRL+   DKDGKPLLP E +E+  P SE  L+D LSEDF   +     +  
Sbjct: 394 EDDETIPSEYRLKPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKP 452

Query: 505 SLKFEDAKLA--AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPD 562
           + K E++K A  A +SE V +T   + Q+ APP   +      DDA++ L+DSLG+++ D
Sbjct: 453 TEKTEESKAAAPAPVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEAD 511

Query: 563 PDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKP 622
           P++ KP+ DKVKEKAK E R+KLGE+++TIPP+YR     +   KP+ P  K+S++   P
Sbjct: 512 PEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPP 569

Query: 623 ADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSK 682
             +   +DALS D     + +      AK     +   S+ P +  +A    + T ++ K
Sbjct: 570 MSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDK 629

Query: 683 PKDD 686
             DD
Sbjct: 630 DLDD 633



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 90/364 (24%), Positives = 153/364 (42%), Gaps = 24/364 (6%)

Query: 331 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 388
           + +P +KP   PR         + +    +  E PSKP EK    +  A +  S    RT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 389 SMCSIQSAPPEPATLKGTVPDDAV---EALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 445
                 SA    A+   T    ++   E  A  + ++   P    P   K K++A + + 
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPH--LPNKKKHKKQAVKTEP 118

Query: 446 EKLGE--KEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNA 503
           EK  +  K +++P         D   K  + + +++Q    S +          +G ++ 
Sbjct: 119 EKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESV 178

Query: 504 SSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDP 563
           + +     K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   
Sbjct: 179 AGITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETE 235

Query: 564 DENKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKP 622
           +EN      +V +   + + ++LG+R+ TIPP+YR LL    ++    PP     DS KP
Sbjct: 236 EENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKP 289

Query: 623 ADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSK 682
               D IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K
Sbjct: 290 IGPDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRK 344

Query: 683 PKDD 686
            + D
Sbjct: 345 VEKD 348


>gi|109637771 calpastatin isoform l [Homo sapiens]
          Length = 654

 Score = 1275 bits (3298), Expect = 0.0
 Identities = 654/686 (95%), Positives = 654/686 (95%), Gaps = 32/686 (4%)

Query: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60
           MNPTETKAVKTEPEKKSQSTK                   PKSLPKQASDTGSNDAHNKK
Sbjct: 1   MNPTETKAVKTEPEKKSQSTK-------------------PKSLPKQASDTGSNDAHNKK 41

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 42  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 101

Query: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 102 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 161

Query: 181 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 240
           PKYRELLAK             PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 162 PKYRELLAK-------------PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 208

Query: 241 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 300
           QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 209 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 268

Query: 301 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 360
           EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 269 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 328

Query: 361 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 420
           EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 329 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 388

Query: 421 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 480
           KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 389 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 448

Query: 481 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 540
           LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 449 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 508

Query: 541 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 600
           SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 509 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 568

Query: 601 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 660
           DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 569 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 628

Query: 661 SKAPKNGGKAKDSAKTTEETSKPKDD 686
           SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 629 SKAPKNGGKAKDSAKTTEETSKPKDD 654


>gi|27765087 calpastatin isoform c [Homo sapiens]
          Length = 430

 Score =  781 bits (2017), Expect = 0.0
 Identities = 391/393 (99%), Positives = 392/393 (99%), Gaps = 1/393 (0%)

Query: 294 DEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 353
           D+AKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED
Sbjct: 39  DQAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 98

Query: 354 FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 413
           FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE
Sbjct: 99  FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 158

Query: 414 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 473
           ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL
Sbjct: 159 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 218

Query: 474 PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA 533
           PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA
Sbjct: 219 PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA 278

Query: 534 PPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP 593
           PPRDTS SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP
Sbjct: 279 PPRDTS-SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP 337

Query: 594 PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK 653
           PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK
Sbjct: 338 PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK 397

Query: 654 CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 686
           CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 398 CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 430



 Score =  206 bits (525), Expect = 4e-53
 Identities = 144/396 (36%), Positives = 213/396 (53%), Gaps = 30/396 (7%)

Query: 169 IEELGKREVTIPPKYR-ELLAKKEG--ITGPPADSSKPIGPDDAIDALSSDFTCGSPTAA 225
           +E+ G+ + TIP +YR +    K+G  +   P +  KP    + ID LS DF        
Sbjct: 48  LEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSE--CK 105

Query: 226 GKKTEKEESTEVLKAQSAGTVRSA-----------APPQEKKRKVEKDTMSDQALEALSA 274
            K ++  E TE  KA +   V  A           APP+    K    T+ D A+EAL+ 
Sbjct: 106 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLK---GTVPDDAVEALAD 162

Query: 275 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP-E 333
           SLG ++A+PE D + + +  + KAKEE  EK GE +ETIP +YRL+   DKDGKPLLP E
Sbjct: 163 SLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE 221

Query: 334 PEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSI 393
            +E+  P SE  L+D LSEDF   +     +  + K E++K A  A +SE V +T   + 
Sbjct: 222 SKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFEDAKLA--AAISEVVSQTPASTT 274

Query: 394 QSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEE 453
           Q+  P   T      DDA++ L+DSLG+++ DP++ KP+ DKVKEKAK E R+KLGE+++
Sbjct: 275 QAGAPPRDTSSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDD 334

Query: 454 TIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDA 511
           TIPP+YR     +   KP+ P  K+S++   P  +   +DALS D     + +      A
Sbjct: 335 TIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTA 394

Query: 512 KLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 547
           K     +   S+ P +  +A    + T ++ K  DD
Sbjct: 395 KDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 430



 Score =  122 bits (306), Expect = 1e-27
 Identities = 100/301 (33%), Positives = 150/301 (49%), Gaps = 31/301 (10%)

Query: 101 KPGDKKKEKKSLTPA-----------VPVESKPDKPSGKSGM--DAALDDLIDTLGGPEE 147
           KP +K +E K+  PA             ++S P +P+   G   D A++ L D+LG  +E
Sbjct: 110 KPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG-KKE 168

Query: 148 TEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYR-ELLAKKEGITGPPADSSK---P 203
            + E+      +V +       E+LG++E TIPP YR E +  K+G    P +S +   P
Sbjct: 169 ADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPP 228

Query: 204 IGPDDAIDALSSDFTCGSPTAAGKKTEKEE----STEVLKAQSAGTVRSAAPPQEKKRKV 259
           +  D  +DALS DF+ G   A+  K E  +     +EV+    A T ++ APP    R  
Sbjct: 229 MSEDFLLDALSEDFS-GPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPP----RDT 283

Query: 260 EKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 319
             D   D AL+ LS SLG RQ +P+ + + +++  + KAK E  +K GE D+TIP EYR 
Sbjct: 284 SSDKDLDDALDKLSDSLGQRQPDPD-ENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRH 342

Query: 320 ---KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAA 376
                  DK  KP   + E+  KP  + + ID LS D D      + S+ T K +  KAA
Sbjct: 343 LLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAA 402

Query: 377 A 377
           +
Sbjct: 403 S 403



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 67/266 (25%), Positives = 114/266 (42%), Gaps = 14/266 (5%)

Query: 10  KTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQ 69
           K E + +     +  V EK  +E + K   + +++P         D   K  + + +++Q
Sbjct: 166 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 225

Query: 70  PSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES--KPDKPSG 127
               S +          +G ++ + +     K      E  S TPA   ++   P   S 
Sbjct: 226 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSS 285

Query: 128 KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELL 187
              +D ALD L D+LG  +   +EN      +V +   + + ++LG+R+ TIPP+YR LL
Sbjct: 286 DKDLDDALDKLSDSLGQRQPDPDENKPMED-KVKEKAKAEHRDKLGERDDTIPPEYRHLL 344

Query: 188 AK--KEGITGPPA----DSSKPIGPDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKA 240
               ++    PP     DS KP    D IDALS D  +C S T   + T K++  +   +
Sbjct: 345 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 404

Query: 241 QSA----GTVRSAAPPQEKKRKVEKD 262
             A    G  + +A   E+  K + D
Sbjct: 405 SKAPKNGGKAKDSAKTTEETSKPKDD 430


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 138/596 (23%), Positives = 225/596 (37%), Gaps = 57/596 (9%)

Query: 114 PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELG 173
           P +P  S   K   +  +        +T+   E+TEE   T    EV++       EE G
Sbjct: 427 PKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVT---EEVTEEEEKEAKEEEG 483

Query: 174 KREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEE 233
           K E     +  E    +E    PPA+ +    P+   +A S         A  K  EKEE
Sbjct: 484 KEEEG--GEEEEAEGGEEETKSPPAEEAA--SPEK--EAKSPVKEEAKSPAEAKSPEKEE 537

Query: 234 STEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEV 293
           +    + +S    +S A  + K     K    ++A          +   P  +    K  
Sbjct: 538 AKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKE--EAKSP 595

Query: 294 DEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 353
            EAK+ E+      E+ ++ P+E +     +      +  PE+   P  E     E ++ 
Sbjct: 596 AEAKSPEKAKSPVKEEAKS-PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKS 654

Query: 354 FDRSECK--EKPSKPTEKTEESKAAAPAPV-SEAVCRTSMCS-IQSAPPEPATLKGTVPD 409
            ++ E K  EK   P +   +S   A +PV +EA       S ++     P   K  V +
Sbjct: 655 PEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKE 714

Query: 410 DAVEA-LADSLGKKEAD-PEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDK 467
           +A     A S  K+EA  PE  K     VKE+AK  ++ K  EK +T+       +VK  
Sbjct: 715 EAKSPEKAKSPVKEEAKTPEKAK---SPVKEEAKSPEKAKSPEKAKTL-------DVKSP 764

Query: 468 DGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAA--------AISE 519
           + K    +E++       E      + E+   P+ A S   EDAK             S 
Sbjct: 765 EAKTPAKEEARSPADKFPEK-AKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSP 823

Query: 520 VVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA-- 577
           V  +      +   PP+   +         ++  DS  +  P  +  KP  ++ KE A  
Sbjct: 824 VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883

Query: 578 -----KAEHRDKLGERDDTIP-PEYRHLLDDNGQDKPVKPPTKKSEDSKKPAD--DQDPI 629
                K E + +  E    +P PE         ++ P K   K+    K+  +   ++P 
Sbjct: 884 KPKESKVEAKKEEAEDKKKVPTPE---------KEAPAKVEVKEDAKPKEKTEVAKKEPD 934

Query: 630 DALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKT-TEETSKPK 684
           DA + +        E +      K +KA    + PK   KAK+  KT ++E SKPK
Sbjct: 935 DAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPK 990



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 148/643 (23%), Positives = 251/643 (39%), Gaps = 85/643 (13%)

Query: 3    PTETKAVKTEPEKK----SQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHN 58
            P+ +  +K + E+K     +S K +V+ E++++E +  E    +   +   + G  +   
Sbjct: 430  PSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGG 489

Query: 59   KKAVSRSAEQQ----PSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTP 114
            ++  +   E++    P+E++  P+ + +  +    +S A       K  +K++ K     
Sbjct: 490  EEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPA-----EAKSPEKEEAKSPAEV 544

Query: 115  AVPVESK-PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDP--MSSTYIEE 171
              P ++K P K   KS  +A           PE+ E ++      EV  P    S   EE
Sbjct: 545  KSPEKAKSPAKEEAKSPPEAK---------SPEKEEAKSPA----EVKSPEKAKSPAKEE 591

Query: 172  LGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDA-LSSDFTCGSPTAA-GKKT 229
                     P+  +   K+E  +  PA++  P+  +    A + S     SPT    K  
Sbjct: 592  AKSPAEAKSPEKAKSPVKEEAKS--PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSP 649

Query: 230  EKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA--EPELDL 287
            EK +S E  +A+S    +S    + K  +  K  +  +A     A    ++    PE   
Sbjct: 650  EKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAK 709

Query: 288  RSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELI 347
              +KE  EAK+ E+      E+ +T   E    P  ++   P      EK K   +++ +
Sbjct: 710  SPVKE--EAKSPEKAKSPVKEEAKT--PEKAKSPVKEEAKSP------EKAKSPEKAKTL 759

Query: 348  DELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTV 407
            D  S +  ++  KE+   P +K  E    A +PV E V              P   K  +
Sbjct: 760  DVKSPEA-KTPAKEEARSPADKFPEK---AKSPVKEEV------------KSPEKAKSPL 803

Query: 408  PDDAVEALADSLGKKEADP----EDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEE 463
             +DA +A    + KKE       E+ KP   KVKE  K+ + EK        P   + EE
Sbjct: 804  KEDA-KAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA-------PATPKTEE 855

Query: 464  VKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQ 523
             KD   K   PK  KE   P  E+    A+ +       A   + ED K      E  + 
Sbjct: 856  KKDSK-KEEAPK--KEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPT-PEKEAP 911

Query: 524  TPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPM--------EDKVKE 575
                  +   P   T  + K+ DDA  K      +++    E K          E+K K 
Sbjct: 912  AKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKT 971

Query: 576  KAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSED 618
            +AKA+  DK   ++ + P   +     +   K  KPP K +ED
Sbjct: 972  EAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 122/528 (23%), Positives = 208/528 (39%), Gaps = 67/528 (12%)

Query: 183 YRELLAKKEGITG-PPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQ 241
           YR+LL  +E   G  P   S P G    I ++S+     S        + E+ T +++ Q
Sbjct: 402 YRKLLEGEECRIGFGPIPFSLPEGLPK-IPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQ 460

Query: 242 SAGT-VRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQ---------AEPELDLRS-I 290
           +  T V      +E+K   E++   ++  E   A  G  +         A PE + +S +
Sbjct: 461 TEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPV 520

Query: 291 KEVDE--AKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELID 348
           KE  +  A+AK  + E+     E    E    PA ++   P   +  EK + +S +E+  
Sbjct: 521 KEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEV-- 578

Query: 349 ELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVP 408
             S +  +S  KE+   P E     KA +P              ++     PA  K  V 
Sbjct: 579 -KSPEKAKSPAKEEAKSPAEAKSPEKAKSP--------------VKEEAKSPAEAKSPVK 623

Query: 409 DDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKD 468
           ++A         K  A+ +  +      KE+AK  ++ K  EKEE   P+     VK + 
Sbjct: 624 EEA---------KSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674

Query: 469 GKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAST 528
             P   K S  +    S +     + E+   P+ A S   E+AK        V +   + 
Sbjct: 675 KSPEKAK-SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP 733

Query: 529 TQAGAPPRDTSQSD---------KDLDDALDKLSDSLGQRQPDPDENKPMEDK--VKEKA 577
            +A +P ++ ++S          K LD    +      +    P +  P + K  VKE+ 
Sbjct: 734 EKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEV 793

Query: 578 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 637
           K+  + K   ++D   PE      +  + + VK P K+ E  ++    + P  A   + +
Sbjct: 794 KSPEKAKSPLKEDAKAPE-----KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKA---EEE 845

Query: 638 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKD 685
             P+T +T +   KD  K+ A   +AP    K K   K      KPK+
Sbjct: 846 KAPATPKTEEK--KDSKKEEAPKKEAP----KPKVEEKKEPAVEKPKE 887



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 114/498 (22%), Positives = 190/498 (38%), Gaps = 37/498 (7%)

Query: 2    NPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKA 61
            +P E K+ + E E KS +   S    K   + + K   E KS  K+ + + +     +KA
Sbjct: 526  SPAEAKSPEKE-EAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKA 584

Query: 62   VSRSAEQ--QPSEKSTEPKTKP--QDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 117
             S + E+   P+E  +  K K   ++   +  E+ + +   +  P + K  +K+ +P   
Sbjct: 585  KSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKE 644

Query: 118  VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV 177
                P+K       +A   +   +    E    E      P  ++  S    +   K E 
Sbjct: 645  EAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAK--SPVKAEAKSPEKAKSPVKEEA 702

Query: 178  TIPPK----YRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEE 233
              P K     +E     E    P  + +K   P+ A   +  +    SP  A K  EK +
Sbjct: 703  KSPEKAKSPVKEEAKSPEKAKSPVKEEAKT--PEKAKSPVKEE--AKSPEKA-KSPEKAK 757

Query: 234  STEV----LKAQSAGTVRSAAP--PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDL 287
            + +V     K  +    RS A   P++ K  V+++  S    E   + L      PE ++
Sbjct: 758  TLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSP---EKAKSPLKEDAKAPEKEI 814

Query: 288  RSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELI 347
               +EV     +EEK ++    +    +E    PAT K  +    + EE PK  +    +
Sbjct: 815  PKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKV 874

Query: 348  DELSEDFDRSECKEKPSKPTEKTEES--KAAAPAPVSEAVCRTSMCS-------IQSAPP 398
            +E  E       K K SK   K EE+  K   P P  EA  +  +          + A  
Sbjct: 875  EEKKEPAVE---KPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKK 931

Query: 399  EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 458
            EP   K   P    E    +  KK+   E  K   +K K +AK ++ +K   KE + P  
Sbjct: 932  EPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKA 991

Query: 459  YRLEEVKDKDGKPLLPKE 476
             + E+    D K   P E
Sbjct: 992  EKAEKSSSTDQKDSKPPE 1009



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 87/396 (21%), Positives = 149/396 (37%), Gaps = 47/396 (11%)

Query: 2    NPTETKAVKTEPEKKSQSTKLSVVHEKKSQE-GKPKEHTEPKSLPKQASDTGSNDAHNKK 60
            +P + K+ + E  K  +  K  V  E KS E  K     E KS  K  S         +K
Sbjct: 648  SPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEK 707

Query: 61   AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120
            A S   E+  S +  +   K +       +S     A S +     ++ K+L    P   
Sbjct: 708  AKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAK 767

Query: 121  KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180
             P K   +S  D            PE+ +        P   +  S    +   K +   P
Sbjct: 768  TPAKEEARSPADKF----------PEKAKS-------PVKEEVKSPEKAKSPLKEDAKAP 810

Query: 181  PKYRELLAKKEGITGPPADSSKP--IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVL 238
             K    + KKE +  P  +  KP  +   +       +    +P    KK  K+E     
Sbjct: 811  EKE---IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKK 867

Query: 239  KAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKA 298
            +A          P  EK ++ + +   ++A +        ++A  +++++     ++AK 
Sbjct: 868  EAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVK-----EDAKP 922

Query: 299  KEEKLEKCGEDDETIPSEYRLKPATDKDGKP--------LLPEPEEKPKPRSESELIDE- 349
            KE K E   ++ +   ++   KPA  K+  P           +PEEKPK  ++++  D+ 
Sbjct: 923  KE-KTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKT 981

Query: 350  LSEDFDR---------SECKEKPSKPTEKTEESKAA 376
            LS++  +         S   +K SKP EK  E KAA
Sbjct: 982  LSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAA 1017



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 59/270 (21%), Positives = 103/270 (38%), Gaps = 46/270 (17%)

Query: 428 DGKPVMDKVKE--KAKEEDREKLGEK--------EETIPPDYRLEEVKDKDGKPLLPKES 477
           +G P +  V    K K E++ K+ EK        EE        EEV +++ K    +E 
Sbjct: 424 EGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEG 483

Query: 478 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 537
           KE+     E        E   G +   S   E+A              +   +A +P ++
Sbjct: 484 KEEEGGEEE--------EAEGGEEETKSPPAEEAA-------------SPEKEAKSPVKE 522

Query: 538 TSQSDKDLDDALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEY 596
            ++S  +              + P+ +E K P E K  EKAK+  +++     +   PE 
Sbjct: 523 EAKSPAEA-------------KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEK 569

Query: 597 RHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKK 656
                      P K  +   E++K PA+ + P  A S   +   S  E +++  K++ K 
Sbjct: 570 EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAE-AKSPVKEEAKS 628

Query: 657 AASSSKAPKNGGKAKDSAKTTEETSKPKDD 686
            A      K     K+ AK+ E+   P+ +
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKAKSPEKE 658


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 101/401 (25%), Positives = 155/401 (38%), Gaps = 65/401 (16%)

Query: 224 AAGKKTEKEESTEVLKAQSAGTVRSAAPP-------------QEKKRKVEKDTMSDQALE 270
           AA +K E+ E+ E   A     V++ AP              QE++ + ++   SDQA E
Sbjct: 491 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 550

Query: 271 ALSASLGT------RQAEPELDLRSIKEVDEAK---AKEEKLEKCGEDDETIPSEYRLKP 321
             S   G+       Q E E +  +  E  EAK     EEK E+    +E +      KP
Sbjct: 551 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 610

Query: 322 ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE-ESKAAAPAP 380
              K   P  P  E+   P  +S + ++      +S  +EK   P  K+  E K  +P  
Sbjct: 611 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV- 669

Query: 381 VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD--SLGKKEADPEDGKPVMDKVKE 438
                         S  P     K  VP   VE       +GK E   E+ K    +VKE
Sbjct: 670 --------------SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK----EVKE 711

Query: 439 KAKEEDREKLGEKEETIPPDYRLEE-VKD----------KDGKPLLPKESKEQLPPMSED 487
             KEE  EK  EK + +P   + E  VK+          K  K  L KE+KE+  P+ ++
Sbjct: 712 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 771

Query: 488 FLLDAL-----SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSD 542
              +       SE+    + A   + ED  +   + E   +    T + G+      +  
Sbjct: 772 KEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV-EGKEEVEQETKEKGS---GREEEK 827

Query: 543 KDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD 583
             + + LD LS +  ++  D  E K +  K  EK  +E  D
Sbjct: 828 GVVTNGLD-LSPADEKKGGDKSEEKVVVTKTVEKITSEGGD 867



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 83/383 (21%), Positives = 137/383 (35%), Gaps = 51/383 (13%)

Query: 5   ETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSND----AHNKK 60
           E  A K  P K +         EK+ +EG+ +E  E +      ++ G ++    +  ++
Sbjct: 504 EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 563

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEK-KSLTPAVPVE 119
                 E +   +  E + K +  +    E VA    +      +K EK KS  P  PVE
Sbjct: 564 GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVE 623

Query: 120 SKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTI 179
            K   P  KS                   EE+           P+  + +EE GK  V  
Sbjct: 624 EKGKSPVPKS-----------------PVEEKG--------KSPVPKSPVEEKGKSPV-- 656

Query: 180 PPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLK 239
           P    E   K      P  + +K   P   ++   S    G      K+ E++E  E  K
Sbjct: 657 PKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGK--GEQKEEEEKEVKEAPK 714

Query: 240 AQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAK 299
            +             +K+K E     +   E ++    T+  +  L+ +  KE  +   +
Sbjct: 715 EEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTI---TKSVKVHLE-KETKEEGKPLQQ 770

Query: 300 EEKLEKCGED--DETIPSEYRLKPATDKD--------GKPLLPEPEEKPKPRSESELIDE 349
           E++ EK G +   E   S+   K +  +D        GK  + E E K K     E    
Sbjct: 771 EKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEV-EQETKEKGSGREEEKGV 829

Query: 350 LSEDFDRSECKEKPSKPTEKTEE 372
           ++   D S   EK  K  +K+EE
Sbjct: 830 VTNGLDLSPADEK--KGGDKSEE 850



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 89/391 (22%), Positives = 138/391 (35%), Gaps = 52/391 (13%)

Query: 211 DALSSDFTCGSPTAAGKKTEKEESTE--VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQA 268
           D L+         AA +K  + E T          G + +  PP     K++K  +    
Sbjct: 386 DLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPK 445

Query: 269 LEAL---------SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 319
           L+              +   ++E E  L +I E      KEEK E   E +E   +E   
Sbjct: 446 LKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE 505

Query: 320 KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK---------- 369
             A     K   PE +E+   + E E  +E  E+ + ++  +     +EK          
Sbjct: 506 VAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE 565

Query: 370 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDG 429
            EE +  A A   EA  +     ++    E AT +  V D  VE       +K   P   
Sbjct: 566 QEEGETEAEAEGEEAEAKEEK-KVEEKSEEVATKEELVADAKVEK-----PEKAKSPVPK 619

Query: 430 KPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFL 489
            PV +K K    +   E   EK ++  P   +EE K K   P  P E K + P       
Sbjct: 620 SPVEEKGKSPVPKSPVE---EKGKSPVPKSPVEE-KGKSPVPKSPVEEKGKSPVSK---- 671

Query: 490 LDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDAL 549
              + E    P   S +  E+AK  A + +   Q      +    P++     K+     
Sbjct: 672 -SPVEEKAKSPVPKSPV--EEAKSKAEVGK-GEQKEEEEKEVKEAPKEEKVEKKE----- 722

Query: 550 DKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 580
                   ++  D  E K  E  VKE+A AE
Sbjct: 723 --------EKPKDVPEKKKAESPVKEEAVAE 745



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 80/367 (21%), Positives = 143/367 (38%), Gaps = 54/367 (14%)

Query: 4   TETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAH------ 57
           TE  AV  + EKK  + +     E + +E   K+     + P+   + G  +        
Sbjct: 477 TEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEE 536

Query: 58  ---NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTP 114
              ++ A S  AE+  SEK  E  ++ ++     GE+ A      G+  + K+EKK    
Sbjct: 537 EEEDEGAKSDQAEEGGSEK--EGSSEKEEGEQEEGETEA---EAEGEEAEAKEEKK---- 587

Query: 115 AVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGK 174
              VE K ++ + K                 EE   +       +   P+  + +EE GK
Sbjct: 588 ---VEEKSEEVATK-----------------EELVADAKVEKPEKAKSPVPKSPVEEKGK 627

Query: 175 REVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEES 234
             V  P    E   K      P  +  K   P   ++         SP     K+   +S
Sbjct: 628 SPV--PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKS 685

Query: 235 TEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVD 294
             V +A+S   V      +E++++V K+   ++ +E        ++ E   D+   K+  
Sbjct: 686 -PVEEAKSKAEVGKGEQKEEEEKEV-KEAPKEEKVE--------KKEEKPKDVPEKKKA- 734

Query: 295 EAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDF 354
           E+  KEE + +     +++  +  L+  T ++GKPL  E +EK K   E    +E S+  
Sbjct: 735 ESPVKEEAVAEVVTITKSV--KVHLEKETKEEGKPLQQE-KEKEKAGGEGGSEEEGSDKG 791

Query: 355 DRSECKE 361
            +   KE
Sbjct: 792 AKGSRKE 798



 Score = 30.8 bits (68), Expect = 4.4
 Identities = 38/173 (21%), Positives = 63/173 (36%), Gaps = 26/173 (15%)

Query: 2   NPTETKAVKTEP----EKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAH 57
           +P E K     P    E+K +S       E+K++   PK   E      +       +  
Sbjct: 646 SPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEE 705

Query: 58  NKKAVSRSAEQQPSEKSTEPKTKPQDMISAG---GESVAGITAIS--------------G 100
            K+      E++  +K  +PK  P+   +      E+VA +  I+              G
Sbjct: 706 EKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEG 765

Query: 101 KP--GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEE 151
           KP   +K+KEK         E       G    D A++  ++   G EE E+E
Sbjct: 766 KPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVE---GKEEVEQE 815


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 101/401 (25%), Positives = 155/401 (38%), Gaps = 65/401 (16%)

Query: 224 AAGKKTEKEESTEVLKAQSAGTVRSAAPP-------------QEKKRKVEKDTMSDQALE 270
           AA +K E+ E+ E   A     V++ AP              QE++ + ++   SDQA E
Sbjct: 115 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174

Query: 271 ALSASLGT------RQAEPELDLRSIKEVDEAK---AKEEKLEKCGEDDETIPSEYRLKP 321
             S   G+       Q E E +  +  E  EAK     EEK E+    +E +      KP
Sbjct: 175 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 234

Query: 322 ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE-ESKAAAPAP 380
              K   P  P  E+   P  +S + ++      +S  +EK   P  K+  E K  +P  
Sbjct: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV- 293

Query: 381 VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD--SLGKKEADPEDGKPVMDKVKE 438
                         S  P     K  VP   VE       +GK E   E+ K    +VKE
Sbjct: 294 --------------SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK----EVKE 335

Query: 439 KAKEEDREKLGEKEETIPPDYRLEE-VKD----------KDGKPLLPKESKEQLPPMSED 487
             KEE  EK  EK + +P   + E  VK+          K  K  L KE+KE+  P+ ++
Sbjct: 336 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 395

Query: 488 FLLDAL-----SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSD 542
              +       SE+    + A   + ED  +   + E   +    T + G+      +  
Sbjct: 396 KEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV-EGKEEVEQETKEKGS---GREEEK 451

Query: 543 KDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD 583
             + + LD LS +  ++  D  E K +  K  EK  +E  D
Sbjct: 452 GVVTNGLD-LSPADEKKGGDKSEEKVVVTKTVEKITSEGGD 491



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 83/383 (21%), Positives = 137/383 (35%), Gaps = 51/383 (13%)

Query: 5   ETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSND----AHNKK 60
           E  A K  P K +         EK+ +EG+ +E  E +      ++ G ++    +  ++
Sbjct: 128 EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 187

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEK-KSLTPAVPVE 119
                 E +   +  E + K +  +    E VA    +      +K EK KS  P  PVE
Sbjct: 188 GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVE 247

Query: 120 SKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTI 179
            K   P  KS                   EE+           P+  + +EE GK  V  
Sbjct: 248 EKGKSPVPKS-----------------PVEEKG--------KSPVPKSPVEEKGKSPV-- 280

Query: 180 PPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLK 239
           P    E   K      P  + +K   P   ++   S    G      K+ E++E  E  K
Sbjct: 281 PKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGK--GEQKEEEEKEVKEAPK 338

Query: 240 AQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAK 299
            +             +K+K E     +   E ++    T+  +  L+ +  KE  +   +
Sbjct: 339 EEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTI---TKSVKVHLE-KETKEEGKPLQQ 394

Query: 300 EEKLEKCGED--DETIPSEYRLKPATDKD--------GKPLLPEPEEKPKPRSESELIDE 349
           E++ EK G +   E   S+   K +  +D        GK  + E E K K     E    
Sbjct: 395 EKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEV-EQETKEKGSGREEEKGV 453

Query: 350 LSEDFDRSECKEKPSKPTEKTEE 372
           ++   D S   EK  K  +K+EE
Sbjct: 454 VTNGLDLSPADEK--KGGDKSEE 474



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 89/391 (22%), Positives = 138/391 (35%), Gaps = 52/391 (13%)

Query: 211 DALSSDFTCGSPTAAGKKTEKEESTE--VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQA 268
           D L+         AA +K  + E T          G + +  PP     K++K  +    
Sbjct: 10  DLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPK 69

Query: 269 LEAL---------SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 319
           L+              +   ++E E  L +I E      KEEK E   E +E   +E   
Sbjct: 70  LKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE 129

Query: 320 KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK---------- 369
             A     K   PE +E+   + E E  +E  E+ + ++  +     +EK          
Sbjct: 130 VAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE 189

Query: 370 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDG 429
            EE +  A A   EA  +     ++    E AT +  V D  VE       +K   P   
Sbjct: 190 QEEGETEAEAEGEEAEAKEEK-KVEEKSEEVATKEELVADAKVEK-----PEKAKSPVPK 243

Query: 430 KPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFL 489
            PV +K K    +   E   EK ++  P   +EE K K   P  P E K + P       
Sbjct: 244 SPVEEKGKSPVPKSPVE---EKGKSPVPKSPVEE-KGKSPVPKSPVEEKGKSPVSK---- 295

Query: 490 LDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDAL 549
              + E    P   S +  E+AK  A + +   Q      +    P++     K+     
Sbjct: 296 -SPVEEKAKSPVPKSPV--EEAKSKAEVGK-GEQKEEEEKEVKEAPKEEKVEKKE----- 346

Query: 550 DKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 580
                   ++  D  E K  E  VKE+A AE
Sbjct: 347 --------EKPKDVPEKKKAESPVKEEAVAE 369



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 80/367 (21%), Positives = 143/367 (38%), Gaps = 54/367 (14%)

Query: 4   TETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAH------ 57
           TE  AV  + EKK  + +     E + +E   K+     + P+   + G  +        
Sbjct: 101 TEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEE 160

Query: 58  ---NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTP 114
              ++ A S  AE+  SEK  E  ++ ++     GE+ A      G+  + K+EKK    
Sbjct: 161 EEEDEGAKSDQAEEGGSEK--EGSSEKEEGEQEEGETEA---EAEGEEAEAKEEKK---- 211

Query: 115 AVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGK 174
              VE K ++ + K                 EE   +       +   P+  + +EE GK
Sbjct: 212 ---VEEKSEEVATK-----------------EELVADAKVEKPEKAKSPVPKSPVEEKGK 251

Query: 175 REVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEES 234
             V  P    E   K      P  +  K   P   ++         SP     K+   +S
Sbjct: 252 SPV--PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKS 309

Query: 235 TEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVD 294
             V +A+S   V      +E++++V K+   ++ +E        ++ E   D+   K+  
Sbjct: 310 -PVEEAKSKAEVGKGEQKEEEEKEV-KEAPKEEKVE--------KKEEKPKDVPEKKKA- 358

Query: 295 EAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDF 354
           E+  KEE + +     +++  +  L+  T ++GKPL  E +EK K   E    +E S+  
Sbjct: 359 ESPVKEEAVAEVVTITKSV--KVHLEKETKEEGKPLQQE-KEKEKAGGEGGSEEEGSDKG 415

Query: 355 DRSECKE 361
            +   KE
Sbjct: 416 AKGSRKE 422



 Score = 30.8 bits (68), Expect = 4.4
 Identities = 38/173 (21%), Positives = 63/173 (36%), Gaps = 26/173 (15%)

Query: 2   NPTETKAVKTEP----EKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAH 57
           +P E K     P    E+K +S       E+K++   PK   E      +       +  
Sbjct: 270 SPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEE 329

Query: 58  NKKAVSRSAEQQPSEKSTEPKTKPQDMISAG---GESVAGITAIS--------------G 100
            K+      E++  +K  +PK  P+   +      E+VA +  I+              G
Sbjct: 330 EKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEG 389

Query: 101 KP--GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEE 151
           KP   +K+KEK         E       G    D A++  ++   G EE E+E
Sbjct: 390 KPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVE---GKEEVEQE 439


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 169/754 (22%), Positives = 267/754 (35%), Gaps = 122/754 (16%)

Query: 12   EPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPS 71
            EP   S+  K  V  +K  Q    K  T+   L   +S T   D  + K  S++ E+   
Sbjct: 737  EPSVPSEQDKAPVADDKPKQPKMVKPTTD---LVSSSSATTKPDIPSSKVQSQAEEKTTP 793

Query: 72   EKSTEPKTKPQDMISAGGESVAGIT--AISGKPGDKK--------KEKKSLTPAVPVESK 121
               T+   KP       GE V+     AI     D K         E K      PV+ K
Sbjct: 794  PLKTD-SAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKK 852

Query: 122  PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPP 181
             +    ++ M    D      G P       T   G  V  P  S   +E  +R      
Sbjct: 853  EEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTA--GQTVPTPQQSPKPQEQSRR------ 904

Query: 182  KYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQ 241
                       IT  P   S+P  P + +      F        G     + S  +  A 
Sbjct: 905  ----FSLNLGSITDAP--KSQPTTPQETVTGKLFGF--------GASIFSQASNLISTAG 950

Query: 242  SAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE- 300
              G    + P    K+         Q   +      T QA P    +SI    E KA   
Sbjct: 951  QPGPHSQSGPGAPMKQA----PAPSQPPTSQGPPKSTGQAPPA-PAKSIPVKKETKAPAA 1005

Query: 301  EKLEKCGEDDETIP-SEYRLKPATDKDGKPLLPEP---------EEKPKPRSESELI-DE 349
            EKLE   E   T+  +E   KP   KD K L  EP         E+ PKP S   L   E
Sbjct: 1006 EKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTE 1065

Query: 350  LS------EDFDR-SECKEKPS-----KPT-EKTEESKAAAPAPVSEAVCRTSMCSIQSA 396
            L+       +F+  +ECK +        PT   TE  +       ++      +  I+  
Sbjct: 1066 LNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKM 1125

Query: 397  PPEPATLKGT---VPDD------AVEALADSLGKKEAD--PEDGKPVMDKVKEKAK---- 441
            PP P+  K +   VP +      AV      + K+E +   E  K +++KVKE       
Sbjct: 1126 PPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKI 1185

Query: 442  ---------------EEDREKLGEKEETIPPDYRL----EEVKDKDGKPLLPKESKEQLP 482
                           E+D+    ++++ +P + +L    E+++ ++ KPLL    +E+ P
Sbjct: 1186 PPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLL----EEKKP 1241

Query: 483  PMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD----- 537
               +  LL          Q    LK   +++  A  ++  +    T Q G  P+      
Sbjct: 1242 TPEDKKLLPEAKTSAPEEQKHDLLK---SQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGL 1298

Query: 538  TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKE-KAKAEHRDKLGERDDTIPPEY 596
             S + + L    DK + ++ ++   P   KP  D+V+  K K E  D   +   +  P+ 
Sbjct: 1299 PSGTPQSLPKEDDKTTKTIKEQPQPPCTAKP--DQVEPGKEKTEKEDDKSDTSSSQQPKS 1356

Query: 597  RHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCK- 655
               L D G        +     S  P D++D +  L  D  S  S+  +  + AK +   
Sbjct: 1357 PQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTV 1416

Query: 656  ----KAASSSKAPKNGGKAKDSAKTTEETSKPKD 685
                +A +S+ A +   K     + + E  +PKD
Sbjct: 1417 LSILEAQASTLADEKSEKKTQPHEVSPE--QPKD 1448



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 143/693 (20%), Positives = 252/693 (36%), Gaps = 140/693 (20%)

Query: 3    PTETKAVKTEPEK-----KSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAH 57
            PTE+ + KT         K Q  ++    EK   E K KE    + +P   +     +  
Sbjct: 1140 PTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILE-KVKETLSMEKIPPMVTTDQKQEES 1198

Query: 58   NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 117
              +    SA Q+      E K  P++      E    +      P DKK   ++ T A P
Sbjct: 1199 KLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSA-P 1257

Query: 118  VESKPDKPSGKSGMDAALDDLIDTL-------GGPEETEEEN----TTYTGPEVSDPMSS 166
             E K D    KS +  A + L   +       G   +T+ E     T  + P+  D  + 
Sbjct: 1258 EEQKHDLL--KSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTK 1315

Query: 167  TYIEE-----LGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDA-LSSDFTCG 220
            T  E+       K +   P K +    +KE      + S +P  P    D   SSD   G
Sbjct: 1316 TIKEQPQPPCTAKPDQVEPGKEK---TEKEDDKSDTSSSQQPKSPQGLSDTGYSSD---G 1369

Query: 221  SPTAAGK-----KTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSAS 275
              ++ G+      T++++  + LK  S     S + P +   K+E   +S   LEA +++
Sbjct: 1370 ISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLA-KLESTVLS--ILEAQAST 1426

Query: 276  LGTRQAEPELDLRSI-----KEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPL 330
            L   ++E +     +     K+ ++ ++  E LE    ++E   S+   K    KD +  
Sbjct: 1427 LADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQD 1486

Query: 331  LPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSM 390
            +P  ++    + +SE +D+++             +P +  EES  +  +PV +   RTS+
Sbjct: 1487 IPSSKDH---KEKSEFVDDITTR----------REPYDSVEESSESENSPVPQRKRRTSV 1533

Query: 391  CSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGE 450
             S  S                                          ++ K+ED +  GE
Sbjct: 1534 GSSSS------------------------------------------DEYKQEDSQGSGE 1551

Query: 451  KEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFE- 509
            +E+ I     +E   D+D                 ++F+ + L E  S  ++    + + 
Sbjct: 1552 EEDFIRKQI-IEMSADEDAS-----------GSEDDEFIRNQLKEISSSTESQKKEETKG 1599

Query: 510  DAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPM 569
              K+ A     +++  +++    A  R  S  D+D D+A D+ S  L  R+    E+   
Sbjct: 1600 KGKITAGKHRRLTRKSSTSIDEDAGRRH-SWHDED-DEAFDE-SPELKYRETKSQES--- 1653

Query: 570  EDKVKEKAKAEHRDKLGERDDTIPPEY--------RHLLDDNGQDKPVKPPTKKSEDSKK 621
            E+ V        R K  E + TI  +Y          L  D   +  ++  T   ED  +
Sbjct: 1654 EELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSR 1713

Query: 622  -------------PADDQDPIDALSGDLDSCPS 641
                         P      + +L  D DS PS
Sbjct: 1714 GEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPS 1746


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 169/754 (22%), Positives = 267/754 (35%), Gaps = 122/754 (16%)

Query: 12   EPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPS 71
            EP   S+  K  V  +K  Q    K  T+   L   +S T   D  + K  S++ E+   
Sbjct: 737  EPSVPSEQDKAPVADDKPKQPKMVKPTTD---LVSSSSATTKPDIPSSKVQSQAEEKTTP 793

Query: 72   EKSTEPKTKPQDMISAGGESVAGIT--AISGKPGDKK--------KEKKSLTPAVPVESK 121
               T+   KP       GE V+     AI     D K         E K      PV+ K
Sbjct: 794  PLKTD-SAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKK 852

Query: 122  PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPP 181
             +    ++ M    D      G P       T   G  V  P  S   +E  +R      
Sbjct: 853  EEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTA--GQTVPTPQQSPKPQEQSRR------ 904

Query: 182  KYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQ 241
                       IT  P   S+P  P + +      F        G     + S  +  A 
Sbjct: 905  ----FSLNLGSITDAP--KSQPTTPQETVTGKLFGF--------GASIFSQASNLISTAG 950

Query: 242  SAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE- 300
              G    + P    K+         Q   +      T QA P    +SI    E KA   
Sbjct: 951  QPGPHSQSGPGAPMKQA----PAPSQPPTSQGPPKSTGQAPPA-PAKSIPVKKETKAPAA 1005

Query: 301  EKLEKCGEDDETIP-SEYRLKPATDKDGKPLLPEP---------EEKPKPRSESELI-DE 349
            EKLE   E   T+  +E   KP   KD K L  EP         E+ PKP S   L   E
Sbjct: 1006 EKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTE 1065

Query: 350  LS------EDFDR-SECKEKPS-----KPT-EKTEESKAAAPAPVSEAVCRTSMCSIQSA 396
            L+       +F+  +ECK +        PT   TE  +       ++      +  I+  
Sbjct: 1066 LNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKM 1125

Query: 397  PPEPATLKGT---VPDD------AVEALADSLGKKEAD--PEDGKPVMDKVKEKAK---- 441
            PP P+  K +   VP +      AV      + K+E +   E  K +++KVKE       
Sbjct: 1126 PPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKI 1185

Query: 442  ---------------EEDREKLGEKEETIPPDYRL----EEVKDKDGKPLLPKESKEQLP 482
                           E+D+    ++++ +P + +L    E+++ ++ KPLL    +E+ P
Sbjct: 1186 PPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLL----EEKKP 1241

Query: 483  PMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD----- 537
               +  LL          Q    LK   +++  A  ++  +    T Q G  P+      
Sbjct: 1242 TPEDKKLLPEAKTSAPEEQKHDLLK---SQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGL 1298

Query: 538  TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKE-KAKAEHRDKLGERDDTIPPEY 596
             S + + L    DK + ++ ++   P   KP  D+V+  K K E  D   +   +  P+ 
Sbjct: 1299 PSGTPQSLPKEDDKTTKTIKEQPQPPCTAKP--DQVEPGKEKTEKEDDKSDTSSSQQPKS 1356

Query: 597  RHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCK- 655
               L D G        +     S  P D++D +  L  D  S  S+  +  + AK +   
Sbjct: 1357 PQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTV 1416

Query: 656  ----KAASSSKAPKNGGKAKDSAKTTEETSKPKD 685
                +A +S+ A +   K     + + E  +PKD
Sbjct: 1417 LSILEAQASTLADEKSEKKTQPHEVSPE--QPKD 1448



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 143/693 (20%), Positives = 252/693 (36%), Gaps = 140/693 (20%)

Query: 3    PTETKAVKTEPEK-----KSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAH 57
            PTE+ + KT         K Q  ++    EK   E K KE    + +P   +     +  
Sbjct: 1140 PTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILE-KVKETLSMEKIPPMVTTDQKQEES 1198

Query: 58   NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 117
              +    SA Q+      E K  P++      E    +      P DKK   ++ T A P
Sbjct: 1199 KLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSA-P 1257

Query: 118  VESKPDKPSGKSGMDAALDDLIDTL-------GGPEETEEEN----TTYTGPEVSDPMSS 166
             E K D    KS +  A + L   +       G   +T+ E     T  + P+  D  + 
Sbjct: 1258 EEQKHDLL--KSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTK 1315

Query: 167  TYIEE-----LGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDA-LSSDFTCG 220
            T  E+       K +   P K +    +KE      + S +P  P    D   SSD   G
Sbjct: 1316 TIKEQPQPPCTAKPDQVEPGKEK---TEKEDDKSDTSSSQQPKSPQGLSDTGYSSD---G 1369

Query: 221  SPTAAGK-----KTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSAS 275
              ++ G+      T++++  + LK  S     S + P +   K+E   +S   LEA +++
Sbjct: 1370 ISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLA-KLESTVLS--ILEAQAST 1426

Query: 276  LGTRQAEPELDLRSI-----KEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPL 330
            L   ++E +     +     K+ ++ ++  E LE    ++E   S+   K    KD +  
Sbjct: 1427 LADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQD 1486

Query: 331  LPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSM 390
            +P  ++    + +SE +D+++             +P +  EES  +  +PV +   RTS+
Sbjct: 1487 IPSSKDH---KEKSEFVDDITTR----------REPYDSVEESSESENSPVPQRKRRTSV 1533

Query: 391  CSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGE 450
             S  S                                          ++ K+ED +  GE
Sbjct: 1534 GSSSS------------------------------------------DEYKQEDSQGSGE 1551

Query: 451  KEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFE- 509
            +E+ I     +E   D+D                 ++F+ + L E  S  ++    + + 
Sbjct: 1552 EEDFIRKQI-IEMSADEDAS-----------GSEDDEFIRNQLKEISSSTESQKKEETKG 1599

Query: 510  DAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPM 569
              K+ A     +++  +++    A  R  S  D+D D+A D+ S  L  R+    E+   
Sbjct: 1600 KGKITAGKHRRLTRKSSTSIDEDAGRRH-SWHDED-DEAFDE-SPELKYRETKSQES--- 1653

Query: 570  EDKVKEKAKAEHRDKLGERDDTIPPEY--------RHLLDDNGQDKPVKPPTKKSEDSKK 621
            E+ V        R K  E + TI  +Y          L  D   +  ++  T   ED  +
Sbjct: 1654 EELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSR 1713

Query: 622  -------------PADDQDPIDALSGDLDSCPS 641
                         P      + +L  D DS PS
Sbjct: 1714 GEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPS 1746


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 122/634 (19%), Positives = 231/634 (36%), Gaps = 104/634 (16%)

Query: 21  KLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTK 80
           K  +  +K  ++ KP+   + K   K+           +K   ++  ++  EK  +P+TK
Sbjct: 140 KKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETK 199

Query: 81  P---QDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDD 137
               +   +   E     T    K G ++K K++      V+  P KP            
Sbjct: 200 TLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPK----------- 248

Query: 138 LIDTLGGPEETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYRELLAKKEGITGP 196
                   E+ ++E    +  E  D  +   Y+ ++          + +L   +     P
Sbjct: 249 --------EKEDKEKAAVSKHEQKDQYAFCRYMIDIFV--------HGDLKPGQSPAIPP 292

Query: 197 PADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKK 256
           P  + +   P  A  AL             KK EK+ ++E  K +           ++ K
Sbjct: 293 PLPTEQASRPTPASPALEEK------EGEKKKAEKKVTSETKKKEK----------EDIK 336

Query: 257 RKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSE 316
           +K EK+T  D   +    +  T+Q   ++  ++  + DE K   +K +K        P+E
Sbjct: 337 KKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKK--------PAE 388

Query: 317 YRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS-ECKEKPSKPTEKTEESKA 375
                   ++ K    EP + PK         E S   D+  + K + +K        K 
Sbjct: 389 VEQPKGKKQEKKEKHVEPAKSPK--------KEHSVPSDKQVKAKTERAKEEIGAVSIKK 440

Query: 376 AAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDK 435
           A P    E   +T    I+         K       ++      GK+E  P   K   +K
Sbjct: 441 AVPGKKEEKTTKTVEQEIRKE-------KSGKTSSILKDKEPIKGKEEKVPASLK---EK 490

Query: 436 VKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSE 495
             E  K+E   K G++ +  PP  +L+  K++  +P + KE+K   P +SE   +    +
Sbjct: 491 EPETKKDEKMSKAGKEVKPKPP--QLQGKKEEKPEPQIKKEAK---PAISEKVQIH--KQ 543

Query: 496 DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDS 555
           D   P+   S    + K       V+ Q  A T +  A P+ T +++       ++   S
Sbjct: 544 DIVKPEKTVSHGKPEEK-------VLKQVKAVTIEKTAKPKPTKKAEH-----REREPPS 591

Query: 556 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK 615
           +   +P P      E     K K E    + E++     + +HL ++    +        
Sbjct: 592 IKTDKPKPTPKGTSEVTESGKKKTE----ISEKESKEKADMKHLREEKVSTRKESLQLHN 647

Query: 616 SEDSKKPADDQDPIDALSGDLDSCPSTTETSQNT 649
              ++KPA        +S D++  P++ +  + T
Sbjct: 648 VTKAEKPA-------RVSKDVEDVPASKKAKEGT 674



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 136/576 (23%), Positives = 219/576 (38%), Gaps = 111/576 (19%)

Query: 10  KTEPEKKSQSTKLSVVHEKKSQEGK----PKEHTEPKSL------PKQASDTGSNDAHNK 59
           KTE ++K +    + V  K+ ++GK     KE  E K+        K+  +T +     K
Sbjct: 147 KTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQK 206

Query: 60  KAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVE 119
           KA  ++AE+   +   E K   Q+ +      V  +     KP +K+ ++K+        
Sbjct: 207 KA--KTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAV------ 258

Query: 120 SKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPM-SSTYIEELGKREVT 178
           SK ++    +     +D  +     P ++          + S P  +S  +EE    +  
Sbjct: 259 SKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKK 318

Query: 179 IPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPT----------AAGKK 228
              K      KKE       D  K    + AID    +    S T          AA KK
Sbjct: 319 AEKKVTSETKKKE-----KEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKK 373

Query: 229 TEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEAL----SASLGTRQAEPE 284
            EK+E ++  K + A   +     QEKK K  +   S +   ++         T +A+ E
Sbjct: 374 DEKKEDSKKTK-KPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEE 432

Query: 285 LDLRSIKEVDEAKAKEEKLEKCGED-----------------------DETIPSEYRLK- 320
           +   SIK+    K KEEK  K  E                        +E +P+  + K 
Sbjct: 433 IGAVSIKKAVPGK-KEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKE 491

Query: 321 PATDKD------GKPLLPEP-------EEKPKPRSESELIDELSE-------DFDRSECK 360
           P T KD      GK + P+P       EEKP+P+ + E    +SE       D  + E  
Sbjct: 492 PETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKT 551

Query: 361 EKPSKPTEKTEE-------SKAAAPAPVSEAVCR-TSMCSIQSAPPEPATLKGTVPDDAV 412
               KP EK  +        K A P P  +A  R     SI++  P+P T KGT   +  
Sbjct: 552 VSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKP-TPKGT--SEVT 608

Query: 413 EALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPL 472
           E+     GKK+ +  + +    K K   K    EK+  ++E++    +L  V  K  KP 
Sbjct: 609 ES-----GKKKTEISEKE---SKEKADMKHLREEKVSTRKESL----QLHNV-TKAEKPA 655

Query: 473 LPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 508
              +  E +P   +       +ED S  +  S + F
Sbjct: 656 RVSKDVEDVPASKK---AKEGTEDVSPTKQKSPISF 688



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 81/369 (21%), Positives = 140/369 (37%), Gaps = 66/369 (17%)

Query: 4   TETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK-SLPKQASDTGSNDAHNKKAV 62
           +ETK  + E  KK +S K + +  +K + GK  E  +    +  QA+        + K  
Sbjct: 325 SETKKKEKEDIKK-KSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKT 383

Query: 63  SRSAE-QQPSEKSTEPKTK--------------PQD-----MISAGGESVAGITAISGKP 102
            + AE +QP  K  E K K              P D           E +  ++     P
Sbjct: 384 KKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVP 443

Query: 103 GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSD 162
           G  KKE+K+ T  V  E + +K SGK+   + L D  + + G EE    +     PE   
Sbjct: 444 G--KKEEKT-TKTVEQEIRKEK-SGKT--SSILKDK-EPIKGKEEKVPASLKEKEPETKK 496

Query: 163 PMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSP 222
                  E++ K    + PK  +L  KKE    P           + +     D      
Sbjct: 497 D------EKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEK 550

Query: 223 TAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKR-----------KVEKDTMSDQALEA 271
           T +  K E+    +VLK   A T+   A P+  K+           K +K   + +    
Sbjct: 551 TVSHGKPEE----KVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSE 606

Query: 272 LSAS------LGTRQAEPELDLRSIKEVDEAKAKE----------EKLEKCGEDDETIPS 315
           ++ S      +  ++++ + D++ ++E   +  KE          EK  +  +D E +P+
Sbjct: 607 VTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPA 666

Query: 316 EYRLKPATD 324
             + K  T+
Sbjct: 667 SKKAKEGTE 675



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 89/399 (22%), Positives = 142/399 (35%), Gaps = 57/399 (14%)

Query: 3   PTETKAVKTEPEKKSQSTKLSVVHEKKSQEG-KPKEHTE-----PKSLPKQASDTGSNDA 56
           P      + E EKK    K++   +KK +E  K K   E      K  P +AS+T     
Sbjct: 304 PASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTV 363

Query: 57  HNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKS--LTP 114
              K  +++A ++  +K    KTK    +               +P  KK+EKK   + P
Sbjct: 364 ---KIAAQAAAKKDEKKEDSKKTKKPAEVE--------------QPKGKKQEKKEKHVEP 406

Query: 115 AVPVESKPDKPSGKSGMDAALDDLIDTLGG-------PEETEEENTTYTGPEVSDPMSST 167
           A   + +   PS K  + A  +   + +G        P + EE+ T     E+       
Sbjct: 407 AKSPKKEHSVPSDKQ-VKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRK----- 460

Query: 168 YIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGK 227
             E+ GK    +  K   +  K+E +     +       D+ +     +     P   GK
Sbjct: 461 --EKSGKTSSILKDK-EPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGK 517

Query: 228 KTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDL 287
           K EK E             + A P   +K ++ K    D      + S G  +   E  L
Sbjct: 518 KEEKPEPQ---------IKKEAKPAISEKVQIHK---QDIVKPEKTVSHGKPE---EKVL 562

Query: 288 RSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL-KPATDKDGKPLLPEPEEKPKPRSESEL 346
           + +K V   K  + K  K  E  E  P   +  KP     G   + E  +K    SE E 
Sbjct: 563 KQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKES 622

Query: 347 IDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAV 385
            ++      R E      +  +    +KA  PA VS+ V
Sbjct: 623 KEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDV 661



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 65/307 (21%), Positives = 110/307 (35%), Gaps = 59/307 (19%)

Query: 402 TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRL 461
           T KG + +  +        K E   +  + +  KV  K KE+ +EK+ EKE+        
Sbjct: 128 TDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHK 187

Query: 462 EEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVV 521
           E+++ K+ KP     +KEQ    + +   +   ++  G       K E  K  AA  + V
Sbjct: 188 EKIEKKE-KPETKTLAKEQKKAKTAEKSEEKTKKEVKGG------KQEKVKQTAAKVKEV 240

Query: 522 SQTPASTTQAGAPPRDTSQSDKDLD---------------DALDKLSDSLGQRQPDPDEN 566
            +TP+   +     +      +  D               D     S ++    P    +
Sbjct: 241 QKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQAS 300

Query: 567 KP------MEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK--SED 618
           +P      +E+K  EK KAE                          K V   TKK   ED
Sbjct: 301 RPTPASPALEEKEGEKKKAE--------------------------KKVTSETKKKEKED 334

Query: 619 SKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTE 678
            KK ++ +  ID    +       +ET Q T K   + AA   +  ++  K K  A+  +
Sbjct: 335 IKKKSEKETAIDV---EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQ 391

Query: 679 ETSKPKD 685
              K ++
Sbjct: 392 PKGKKQE 398


>gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo
            sapiens]
          Length = 1782

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 132/641 (20%), Positives = 242/641 (37%), Gaps = 102/641 (15%)

Query: 2    NPTETKAVKT--------EPEKKSQSTKLSVVHEKKSQE---GKPKEHTEPKSLPKQASD 50
            +PTE + V T         P KKS+S KL    E+KS++   G   EH+ P + P +   
Sbjct: 749  SPTEGEGVSTWESFKRLVTPRKKSKS-KL----EEKSEDSIAGSGVEHSTPDTEPGKEES 803

Query: 51   TGSND----AHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKK 106
              S         KK      EQ P E +        D        ++   A+  +  + +
Sbjct: 804  WVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQ 863

Query: 107  KEKKSLT-PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPM- 164
            + +KS   P     ++  K   +S +      + D        EE + ++    V++P+ 
Sbjct: 864  QAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLE 923

Query: 165  -----SSTYIEELGKREVTI---PPKYRELLAKKEGITGPP--------------ADSSK 202
                 ++   EE+ +REV     PP   E L +     G                A+++ 
Sbjct: 924  QVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAG 983

Query: 203  PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKD 262
            P+G ++  +A +++ T    +A  + T+  ++TE  +A     V    P  E++ +  ++
Sbjct: 984  PLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTE--EATPVQEVEGGVPDIEEQERRTQE 1041

Query: 263  TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPA 322
             +   A +    S       PE  L+ ++   EA+  EE+ E  G           LK  
Sbjct: 1042 VLQAVAEKVKEESQLPGTGGPEDVLQPVQRA-EAERPEEQAEASG-----------LKKE 1089

Query: 323  TDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVS 382
            TD   K  +   E K +P ++ +++ + +      E  EK  + TE  E          S
Sbjct: 1090 TDVVLK--VDAQEAKTEPFTQGKVVGQTT-----PESFEKAPQVTESIES---------S 1133

Query: 383  EAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPED----GKPVMDKVKE 438
            E V      ++     +   ++  +P D+VE   DS         D    G    D++ E
Sbjct: 1134 ELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVE 1193

Query: 439  KAKEED----REKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ------LPPMSEDF 488
              +E +     +  G + E +P     +E        +  +E+KEQ      L    ++ 
Sbjct: 1194 IHEENEVASGTQSGGTEAEAVPAQ---KERPPAPSSFVFQEETKEQSKMEDTLEHTDKEV 1250

Query: 489  LLDALS--EDFSGPQNASSLKFEDAK-------LAAAISEVVSQTPASTTQAGAPPRDTS 539
             ++ +S      G Q A     E  K       L  +I   ++ +    T+       T 
Sbjct: 1251 SVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTE 1310

Query: 540  QSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 580
            +++   DDAL+  S +  +  P P E + +    +EK +AE
Sbjct: 1311 EAECKKDDALELQSHA--KSPPSPVEREMVVQVEREKTEAE 1349



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 148/739 (20%), Positives = 249/739 (33%), Gaps = 97/739 (13%)

Query: 10  KTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQ 69
           K + EK      L+V  ++        +H +P      A +  S ++  K++  +  E  
Sbjct: 187 KDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSL---GAGEAASKESEPKQSTEKPEETL 243

Query: 70  PSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKS 129
             E+S    + P +     G++V        +  +K+  K + +P  PV S+      K 
Sbjct: 244 KREQSHAEISPPAE----SGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKF 299

Query: 130 GMDAALDDLIDT-LGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLA 188
                      T    P+E E E +     +  + + +   EE GK EV       +L A
Sbjct: 300 FTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDT---EEDGKAEVAS----EKLTA 352

Query: 189 KKEGITGPPADSS---KPIGPDDAIDALSSDFTCGS---------PTAAGKKTEKEE--S 234
            ++     PA+S+   +     + ++  S +   GS         P A     EK E   
Sbjct: 353 SEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQ 412

Query: 235 TEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEV- 293
            EV+      TV      +E+K +VE+   S  A E +      ++AEP  +L  +KE  
Sbjct: 413 EEVVAEVHVSTVEERT--EEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETC 470

Query: 294 -------------DEAKAKEEKLEKCGEDDETIPSEYR-------LKPATDKDGKPLLPE 333
                         + K   +  E    + E + S+ R       LK      G   L  
Sbjct: 471 VSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSG 530

Query: 334 PEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVC-RTSMCS 392
            ++K K     E   E ++        + P    E+  ES A++P    E  C    +  
Sbjct: 531 KKQKGKRGGGDEESGEHTQ-----VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAE 585

Query: 393 IQ--SAPPEPATLKGTVPDDAVEALADSLGKKEADPE---------DGKPVMDKVK---- 437
           +Q      E AT  G    + V   A    KK   P+         D +  +DKVK    
Sbjct: 586 VQQDGEAEEGATSDGEKKREGVTPWASF--KKMVTPKKRVRRPSESDKEDELDKVKSATL 643

Query: 438 ----EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL----PKESKEQLPPMSEDFL 489
                 A E   E  G  EE  P + + +       + L+     K+   +     E+  
Sbjct: 644 SSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGG 703

Query: 490 LDALSEDFSGPQNASSLK--FEDAKLAAAISEVVSQTPASTTQAGAPPR----DTSQSDK 543
             A+  D      A   K    D  LA +      Q  +S  QAG+P       T +S K
Sbjct: 704 PKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFK 763

Query: 544 DLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDN 603
            L     K    L ++  D      +E    +    +    +  +   IP   +   D  
Sbjct: 764 RLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIK-KFIPGRRKKRPDGK 822

Query: 604 GQDKPVKP--PTKKSEDSKK-----PADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKK 656
            +  PV+   PT  +ED        P  + D ++    +      + E  +  A  +  K
Sbjct: 823 QEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK 882

Query: 657 AASSSKAPKNGGKAKDSAK 675
             S S+         D  +
Sbjct: 883 ELSESQVHMMAAAVADGTR 901



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 140/734 (19%), Positives = 263/734 (35%), Gaps = 130/734 (17%)

Query: 27   EKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMIS 86
            E+ ++    +E TE  S   Q +D+  +       V       P  +  E +T  Q+++ 
Sbjct: 988  EEGTEASAAEETTEMVSAVSQLTDS-PDTTEEATPVQEVEGGVPDIEEQERRT--QEVLQ 1044

Query: 87   AGGESVAGITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKSGMDAALDDLIDTLGGP 145
            A  E V   + + G  G +      L P    E+ +P++ +  SG+    D ++      
Sbjct: 1045 AVAEKVKEESQLPGTGGPEDV----LQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQE 1100

Query: 146  EETEE-----------ENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGIT 194
             +TE              +    P+V++ + S+ +    + E     K +E++ ++    
Sbjct: 1101 AKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQ---A 1157

Query: 195  GPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQE 254
             PP     P   +       +DF     T   +  E  E  EV     +G   + A P +
Sbjct: 1158 IPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQ 1217

Query: 255  KKR------------KVEKDTMSD-----------QALEALSASLGTRQAEPELDLRSIK 291
            K+R              E+  M D           + +  LS + GT++A+   D ++ K
Sbjct: 1218 KERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKT-K 1276

Query: 292  EVDEAKAKEEKLEKCGEDDETIPSEYRLK------PATDKDGKPLLPEPEEKPKPRSESE 345
            +V   +  E  ++          +E  LK          KD    L    + P    E E
Sbjct: 1277 DVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVERE 1336

Query: 346  LIDELSEDFDRSECKEKPSKPTEKTEESKAAAPA--PVSEAVCRTSMCSIQSAPPEPATL 403
            ++ ++    +R + + +P+   E+  E + A      VS+ + +T    I     E ++L
Sbjct: 1337 MVVQV----EREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSL 1392

Query: 404  KGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKE---------EDREKLGEKE-- 452
            +G+ P          LG++EA       V  K++ ++ E         E+ + LGE    
Sbjct: 1393 EGSPP--------PCLGQEEA-------VCTKIQVQSSEASFTLTAAAEEEKVLGETANI 1437

Query: 453  ----ETIPP---DYRLEEVKD-----------KDGKPLLPKESKEQLPPMSEDFLLDALS 494
                ET+ P      LEE              +D  P  P    +  P +        LS
Sbjct: 1438 LETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLS 1497

Query: 495  EDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSD 554
             D  G +  +SLK++         EV  Q      +      D    +  L+  L+  S 
Sbjct: 1498 SDLEG-EKTTSLKWKS-------DEVDEQVACQEVKVSVAIEDLEPENGILE--LETKSS 1547

Query: 555  SLGQR--QPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPP 612
             L Q   Q   D+    E+   E   +E + +             H++  + QD   +  
Sbjct: 1548 KLVQNIIQTAVDQFVRTEETATEMLTSELQTQ------------AHVIKADSQDAG-QET 1594

Query: 613  TKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKD 672
             K+ E+ +  A D+ PI +   + +S  +  +   + +KD  + +  +      G    D
Sbjct: 1595 EKEGEEPQASAQDETPITSAKEESES-TAVGQAHSDISKDMSEASEKTMTVEVEGSTVND 1653

Query: 673  SAKTTEETSKPKDD 686
              +  EE   P ++
Sbjct: 1654 --QQLEEVVLPSEE 1665



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 130/716 (18%), Positives = 261/716 (36%), Gaps = 109/716 (15%)

Query: 28   KKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTK-PQDMIS 86
            ++++  +P+E  E   L K+       DA   K    +  +   + + E   K PQ   S
Sbjct: 1070 QRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTES 1129

Query: 87   AGGESVAGITAISGKPGDKKKE---KKSLTP---AVPVESKPDKPSGKSGMDAA----LD 136
                 +          G K +E   ++++ P     P +S+ D  +  +  DA      D
Sbjct: 1130 IESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKD 1189

Query: 137  DLIDTLGGPEETEEENTTYTGPEVSD---------PMSSTYI-----EELGKREVTIPPK 182
            ++++     EE E  + T +G   ++         P  S+++     +E  K E T+   
Sbjct: 1190 EIVEI---HEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHT 1246

Query: 183  YRE-------LLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTE---KE 232
             +E       +L+K EG       + +        + L      G   +  K TE   K 
Sbjct: 1247 DKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKG 1306

Query: 233  ESTEVLKAQSAGTVR----SAAPP-----------QEKKRKVEKDTMSDQALEALSASLG 277
            E TE  + +    +     + +PP           + +K + E   ++++ LE  +A   
Sbjct: 1307 EGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTV 1366

Query: 278  TRQAEPEL----DLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPE 333
            + +   +L    ++  I    E  + E     C   +E + ++ +++ +   +    L  
Sbjct: 1367 SEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSS---EASFTLTA 1423

Query: 334  PEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSI 393
              E+ K   E+  I E  E  + +       + + +  E  AA P    +AV     C  
Sbjct: 1424 AAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPG--EDAVPTGPDCQA 1481

Query: 394  QSAPP-EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKE 452
            +S P    AT K  +  D       SL K ++D  D +    +VK     ED E      
Sbjct: 1482 KSTPVIVSATTKKGLSSDLEGEKTTSL-KWKSDEVDEQVACQEVKVSVAIEDLE------ 1534

Query: 453  ETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAK 512
                P+  + E++ K  K             + ++ +  A+ +     + A+ +   + +
Sbjct: 1535 ----PENGILELETKSSK-------------LVQNIIQTAVDQFVRTEETATEMLTSELQ 1577

Query: 513  LAAAISEVVSQTPASTTQA-GAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMED 571
              A + +  SQ     T+  G  P+ ++Q +  +  A ++ S+S    Q   D +K M +
Sbjct: 1578 TQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEE-SESTAVGQAHSDISKDMSE 1636

Query: 572  ------------------KVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPT 613
                              +++E       +  G    ++P +  H L     +K +  P 
Sbjct: 1637 ASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEP- 1695

Query: 614  KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGK 669
             K ++     DD +  ++   D D+    T+ S +T   K K+   + +     GK
Sbjct: 1696 -KEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGK 1750


>gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo
            sapiens]
          Length = 1684

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 132/641 (20%), Positives = 242/641 (37%), Gaps = 102/641 (15%)

Query: 2    NPTETKAVKT--------EPEKKSQSTKLSVVHEKKSQE---GKPKEHTEPKSLPKQASD 50
            +PTE + V T         P KKS+S KL    E+KS++   G   EH+ P + P +   
Sbjct: 651  SPTEGEGVSTWESFKRLVTPRKKSKS-KL----EEKSEDSIAGSGVEHSTPDTEPGKEES 705

Query: 51   TGSND----AHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKK 106
              S         KK      EQ P E +        D        ++   A+  +  + +
Sbjct: 706  WVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQ 765

Query: 107  KEKKSLT-PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPM- 164
            + +KS   P     ++  K   +S +      + D        EE + ++    V++P+ 
Sbjct: 766  QAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLE 825

Query: 165  -----SSTYIEELGKREVTI---PPKYRELLAKKEGITGPP--------------ADSSK 202
                 ++   EE+ +REV     PP   E L +     G                A+++ 
Sbjct: 826  QVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAG 885

Query: 203  PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKD 262
            P+G ++  +A +++ T    +A  + T+  ++TE  +A     V    P  E++ +  ++
Sbjct: 886  PLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTE--EATPVQEVEGGVPDIEEQERRTQE 943

Query: 263  TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPA 322
             +   A +    S       PE  L+ ++   EA+  EE+ E  G           LK  
Sbjct: 944  VLQAVAEKVKEESQLPGTGGPEDVLQPVQRA-EAERPEEQAEASG-----------LKKE 991

Query: 323  TDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVS 382
            TD   K  +   E K +P ++ +++ + +      E  EK  + TE  E          S
Sbjct: 992  TDVVLK--VDAQEAKTEPFTQGKVVGQTT-----PESFEKAPQVTESIES---------S 1035

Query: 383  EAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPED----GKPVMDKVKE 438
            E V      ++     +   ++  +P D+VE   DS         D    G    D++ E
Sbjct: 1036 ELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVE 1095

Query: 439  KAKEED----REKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ------LPPMSEDF 488
              +E +     +  G + E +P     +E        +  +E+KEQ      L    ++ 
Sbjct: 1096 IHEENEVASGTQSGGTEAEAVPAQ---KERPPAPSSFVFQEETKEQSKMEDTLEHTDKEV 1152

Query: 489  LLDALS--EDFSGPQNASSLKFEDAK-------LAAAISEVVSQTPASTTQAGAPPRDTS 539
             ++ +S      G Q A     E  K       L  +I   ++ +    T+       T 
Sbjct: 1153 SVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTE 1212

Query: 540  QSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 580
            +++   DDAL+  S +  +  P P E + +    +EK +AE
Sbjct: 1213 EAECKKDDALELQSHA--KSPPSPVEREMVVQVEREKTEAE 1251



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 148/739 (20%), Positives = 249/739 (33%), Gaps = 97/739 (13%)

Query: 10  KTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQ 69
           K + EK      L+V  ++        +H +P      A +  S ++  K++  +  E  
Sbjct: 89  KDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSL---GAGEAASKESEPKQSTEKPEETL 145

Query: 70  PSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKS 129
             E+S    + P +     G++V        +  +K+  K + +P  PV S+      K 
Sbjct: 146 KREQSHAEISPPAE----SGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKF 201

Query: 130 GMDAALDDLIDT-LGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLA 188
                      T    P+E E E +     +  + + +   EE GK EV       +L A
Sbjct: 202 FTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDT---EEDGKAEVAS----EKLTA 254

Query: 189 KKEGITGPPADSS---KPIGPDDAIDALSSDFTCGS---------PTAAGKKTEKEE--S 234
            ++     PA+S+   +     + ++  S +   GS         P A     EK E   
Sbjct: 255 SEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQ 314

Query: 235 TEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEV- 293
            EV+      TV      +E+K +VE+   S  A E +      ++AEP  +L  +KE  
Sbjct: 315 EEVVAEVHVSTVEERT--EEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETC 372

Query: 294 -------------DEAKAKEEKLEKCGEDDETIPSEYR-------LKPATDKDGKPLLPE 333
                         + K   +  E    + E + S+ R       LK      G   L  
Sbjct: 373 VSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSG 432

Query: 334 PEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVC-RTSMCS 392
            ++K K     E   E ++        + P    E+  ES A++P    E  C    +  
Sbjct: 433 KKQKGKRGGGDEESGEHTQ-----VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAE 487

Query: 393 IQ--SAPPEPATLKGTVPDDAVEALADSLGKKEADPE---------DGKPVMDKVK---- 437
           +Q      E AT  G    + V   A    KK   P+         D +  +DKVK    
Sbjct: 488 VQQDGEAEEGATSDGEKKREGVTPWASF--KKMVTPKKRVRRPSESDKEDELDKVKSATL 545

Query: 438 ----EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL----PKESKEQLPPMSEDFL 489
                 A E   E  G  EE  P + + +       + L+     K+   +     E+  
Sbjct: 546 SSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGG 605

Query: 490 LDALSEDFSGPQNASSLK--FEDAKLAAAISEVVSQTPASTTQAGAPPR----DTSQSDK 543
             A+  D      A   K    D  LA +      Q  +S  QAG+P       T +S K
Sbjct: 606 PKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFK 665

Query: 544 DLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDN 603
            L     K    L ++  D      +E    +    +    +  +   IP   +   D  
Sbjct: 666 RLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIK-KFIPGRRKKRPDGK 724

Query: 604 GQDKPVKP--PTKKSEDSKK-----PADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKK 656
            +  PV+   PT  +ED        P  + D ++    +      + E  +  A  +  K
Sbjct: 725 QEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK 784

Query: 657 AASSSKAPKNGGKAKDSAK 675
             S S+         D  +
Sbjct: 785 ELSESQVHMMAAAVADGTR 803



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 140/734 (19%), Positives = 263/734 (35%), Gaps = 130/734 (17%)

Query: 27   EKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMIS 86
            E+ ++    +E TE  S   Q +D+  +       V       P  +  E +T  Q+++ 
Sbjct: 890  EEGTEASAAEETTEMVSAVSQLTDS-PDTTEEATPVQEVEGGVPDIEEQERRT--QEVLQ 946

Query: 87   AGGESVAGITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKSGMDAALDDLIDTLGGP 145
            A  E V   + + G  G +      L P    E+ +P++ +  SG+    D ++      
Sbjct: 947  AVAEKVKEESQLPGTGGPEDV----LQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQE 1002

Query: 146  EETEE-----------ENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGIT 194
             +TE              +    P+V++ + S+ +    + E     K +E++ ++    
Sbjct: 1003 AKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQ---A 1059

Query: 195  GPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQE 254
             PP     P   +       +DF     T   +  E  E  EV     +G   + A P +
Sbjct: 1060 IPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQ 1119

Query: 255  KKR------------KVEKDTMSD-----------QALEALSASLGTRQAEPELDLRSIK 291
            K+R              E+  M D           + +  LS + GT++A+   D ++ K
Sbjct: 1120 KERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKT-K 1178

Query: 292  EVDEAKAKEEKLEKCGEDDETIPSEYRLK------PATDKDGKPLLPEPEEKPKPRSESE 345
            +V   +  E  ++          +E  LK          KD    L    + P    E E
Sbjct: 1179 DVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVERE 1238

Query: 346  LIDELSEDFDRSECKEKPSKPTEKTEESKAAAPA--PVSEAVCRTSMCSIQSAPPEPATL 403
            ++ ++    +R + + +P+   E+  E + A      VS+ + +T    I     E ++L
Sbjct: 1239 MVVQV----EREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSL 1294

Query: 404  KGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKE---------EDREKLGEKE-- 452
            +G+ P          LG++EA       V  K++ ++ E         E+ + LGE    
Sbjct: 1295 EGSPP--------PCLGQEEA-------VCTKIQVQSSEASFTLTAAAEEEKVLGETANI 1339

Query: 453  ----ETIPP---DYRLEEVKD-----------KDGKPLLPKESKEQLPPMSEDFLLDALS 494
                ET+ P      LEE              +D  P  P    +  P +        LS
Sbjct: 1340 LETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLS 1399

Query: 495  EDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSD 554
             D  G +  +SLK++         EV  Q      +      D    +  L+  L+  S 
Sbjct: 1400 SDLEG-EKTTSLKWKS-------DEVDEQVACQEVKVSVAIEDLEPENGILE--LETKSS 1449

Query: 555  SLGQR--QPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPP 612
             L Q   Q   D+    E+   E   +E + +             H++  + QD   +  
Sbjct: 1450 KLVQNIIQTAVDQFVRTEETATEMLTSELQTQ------------AHVIKADSQDAG-QET 1496

Query: 613  TKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKD 672
             K+ E+ +  A D+ PI +   + +S  +  +   + +KD  + +  +      G    D
Sbjct: 1497 EKEGEEPQASAQDETPITSAKEESES-TAVGQAHSDISKDMSEASEKTMTVEVEGSTVND 1555

Query: 673  SAKTTEETSKPKDD 686
              +  EE   P ++
Sbjct: 1556 --QQLEEVVLPSEE 1567



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 130/716 (18%), Positives = 261/716 (36%), Gaps = 109/716 (15%)

Query: 28   KKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTK-PQDMIS 86
            ++++  +P+E  E   L K+       DA   K    +  +   + + E   K PQ   S
Sbjct: 972  QRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTES 1031

Query: 87   AGGESVAGITAISGKPGDKKKE---KKSLTP---AVPVESKPDKPSGKSGMDAA----LD 136
                 +          G K +E   ++++ P     P +S+ D  +  +  DA      D
Sbjct: 1032 IESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKD 1091

Query: 137  DLIDTLGGPEETEEENTTYTGPEVSD---------PMSSTYI-----EELGKREVTIPPK 182
            ++++     EE E  + T +G   ++         P  S+++     +E  K E T+   
Sbjct: 1092 EIVEI---HEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHT 1148

Query: 183  YRE-------LLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTE---KE 232
             +E       +L+K EG       + +        + L      G   +  K TE   K 
Sbjct: 1149 DKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKG 1208

Query: 233  ESTEVLKAQSAGTVR----SAAPP-----------QEKKRKVEKDTMSDQALEALSASLG 277
            E TE  + +    +     + +PP           + +K + E   ++++ LE  +A   
Sbjct: 1209 EGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTV 1268

Query: 278  TRQAEPEL----DLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPE 333
            + +   +L    ++  I    E  + E     C   +E + ++ +++ +   +    L  
Sbjct: 1269 SEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSS---EASFTLTA 1325

Query: 334  PEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSI 393
              E+ K   E+  I E  E  + +       + + +  E  AA P    +AV     C  
Sbjct: 1326 AAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPG--EDAVPTGPDCQA 1383

Query: 394  QSAPP-EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKE 452
            +S P    AT K  +  D       SL K ++D  D +    +VK     ED E      
Sbjct: 1384 KSTPVIVSATTKKGLSSDLEGEKTTSL-KWKSDEVDEQVACQEVKVSVAIEDLE------ 1436

Query: 453  ETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAK 512
                P+  + E++ K  K             + ++ +  A+ +     + A+ +   + +
Sbjct: 1437 ----PENGILELETKSSK-------------LVQNIIQTAVDQFVRTEETATEMLTSELQ 1479

Query: 513  LAAAISEVVSQTPASTTQA-GAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMED 571
              A + +  SQ     T+  G  P+ ++Q +  +  A ++ S+S    Q   D +K M +
Sbjct: 1480 TQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEE-SESTAVGQAHSDISKDMSE 1538

Query: 572  ------------------KVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPT 613
                              +++E       +  G    ++P +  H L     +K +  P 
Sbjct: 1539 ASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEP- 1597

Query: 614  KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGK 669
             K ++     DD +  ++   D D+    T+ S +T   K K+   + +     GK
Sbjct: 1598 -KEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGK 1652


>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
          Length = 1163

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 105/533 (19%), Positives = 189/533 (35%), Gaps = 82/533 (15%)

Query: 197 PADSSKPI-----GPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP 251
           P  +S+P      G D++ D  SS    GS +++G  +E E S+   +A       S  P
Sbjct: 407 PGSNSEPSHHNSEGADNSRDDSSSH--SGSESSSGSDSESESSSSDSEANEPSQSASPEP 464

Query: 252 PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDE 311
                 K + D   ++        +   +  P   + S     +   KE + +  G    
Sbjct: 465 EPPPTNKWQLDNWLNK--------VNPHKVSPASSVDSNIPSSQGYKKEGREQGTGNS-- 514

Query: 312 TIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE 371
                      TD  G    P+      P  +S+ I + SE     +     S  T +  
Sbjct: 515 ----------YTDTSG----PKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRR 560

Query: 372 ESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGK---KEADPED 428
                 P    +A        ++     P  L  ++P    +A      K   K+     
Sbjct: 561 TVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKESKSS 620

Query: 429 GKPVMDKVKEKAKEEDREKLGE------------KEETIPPDYRLEEVKDKDGKPLLPKE 476
            +P  +K K K+  +  +K  E            + E++PP  +  +  + +  P+ P  
Sbjct: 621 PRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSS 680

Query: 477 SKEQ--------LPPMSEDFLLDALSEDFSGPQNASSL--KFEDAKLAAAISEVVSQT-P 525
            +E+          PM E  LL  LSE    P +   L  K +   L     +   +T P
Sbjct: 681 VEEEDSFFRQRMFSPMEEKELLSPLSE----PDDRYPLIVKIDLNLLTRIPGKPYKETEP 736

Query: 526 ASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKL 585
               +   P + T ++ K    A +K+S+   ++  + D+N+  E K   K K E ++  
Sbjct: 737 PKGEKKNVPEKHTREAQKQ---ASEKVSNKGKRKHKNEDDNRASESK---KPKTEDKNSA 790

Query: 586 GERDDT-------IPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 638
           G +  +          + + LL       P K P  +    K+       + + S     
Sbjct: 791 GHKPSSNRESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKE 850

Query: 639 CPSTTETSQNTAKDKCKKAASSS-------KAPKNGGKAKDSAKTTEETSKPK 684
              +++ S +T+K K  +  +SS       KAP +      SA T  ++SKP+
Sbjct: 851 TSGSSKNSSSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTL-DSSKPR 902



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 118/581 (20%), Positives = 197/581 (33%), Gaps = 128/581 (22%)

Query: 30  SQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEK-STEPKTKPQDMISAG 88
           + EG      +  S     S +GS D+ ++ + S S   +PS+  S EP+  P +     
Sbjct: 417 NSEGADNSRDDSSSHSGSESSSGS-DSESESSSSDSEANEPSQSASPEPEPPPTNKWQLD 475

Query: 89  GESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSG--KSGMDAALDDLIDTLGGPE 146
                            K     ++PA  V+S      G  K G +    +      GP+
Sbjct: 476 NWL-------------NKVNPHKVSPASSVDSNIPSSQGYKKEGREQGTGNSYTDTSGPK 522

Query: 147 ET------EEENTTYTGPE--------VSDPMSSTYIEELGKREVTIPPKYRELLAKKEG 192
           ET       +  T   G E         +   S+T    +GK++    PK  E  A +E 
Sbjct: 523 ETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQ----PKKAEKAAAEEP 578

Query: 193 ITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPP 252
             G   +S  P+           D     P++  K   K      +K +S    +S+  P
Sbjct: 579 RGGLKIESETPV-----------DLASSMPSSRHKAATKGSRKPNIKKES----KSSPRP 623

Query: 253 QEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDET 312
             +K+K +  + S Q                    R I E D + +         ++ E+
Sbjct: 624 TAEKKKYKSTSKSSQ------------------KSREIIETDTSSSD-------SDESES 658

Query: 313 IPSEYRLKPATDKDGKPLLPEPEEKP---------KPRSESELIDELSEDFDRSECKEK- 362
           +P   +     + +  P+ P   E+           P  E EL+  LSE  DR     K 
Sbjct: 659 LPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKI 718

Query: 363 --------PSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEA 414
                   P KP ++TE  K                   +   PE  T +      A E 
Sbjct: 719 DLNLLTRIPGKPYKETEPPKGE-----------------KKNVPEKHTRE--AQKQASEK 759

Query: 415 LADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKD--GKPL 472
           +++   +K  + +D +    K   K K ED+   G K  +     +    K+KD    P 
Sbjct: 760 VSNKGKRKHKNEDDNRASESK---KPKTEDKNSAGHKPSSNRESSKQSAAKEKDLLPSPA 816

Query: 473 LPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAG 532
            P  SK+  P          +S+  S   +++S K              S+  +ST++  
Sbjct: 817 GPVPSKD--PKTEHGSRKRTISQSSSLKSSSNSNKETSGS---------SKNSSSTSKQK 865

Query: 533 APPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKV 573
                TS S K++ +     S +     P  D +KP   K+
Sbjct: 866 KTEGKTSSSSKEVKEKAPSSSSNCPPSAPTLDSSKPRRTKL 906



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 98/422 (23%), Positives = 160/422 (37%), Gaps = 67/422 (15%)

Query: 13  PEKKSQST--KLSVVHEKKSQEGKPKEHTEPKS-LPKQASDTGSNDAHNKKAVSRSAEQQ 69
           P++ S +T  + S   +K S+ G+ ++ +  +S    Q    G      KKA   +AE+ 
Sbjct: 521 PKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQP--KKAEKAAAEEP 578

Query: 70  PSEKSTEPKTKPQDMISAGGESV-AGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGK 128
                 E +T P D+ S+   S     T  S KP  KK+ K S  P    E K  K + K
Sbjct: 579 RGGLKIESET-PVDLASSMPSSRHKAATKGSRKPNIKKESKSS--PRPTAEKKKYKSTSK 635

Query: 129 SGMDAALDDLIDTLGGPEETEEENT------TYTGPEVS-DPMSSTYIEE---LGKREVT 178
           S   +   ++I+T     +++E  +      T   PE +  P+  + +EE     ++ + 
Sbjct: 636 SSQKSR--EIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMF 693

Query: 179 IPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVL 238
            P + +ELL          +  S+P      I  +  +     P    K+TE        
Sbjct: 694 SPMEEKELL----------SPLSEPDDRYPLIVKIDLNLLTRIPGKPYKETE-------- 735

Query: 239 KAQSAGTVRSAAPPQEKKRKVEKDT--MSDQALEALSASLGTRQAEPELDLRSIKEVDEA 296
                       P  EKK   EK T     QA E +S + G R+ + E D R+    +  
Sbjct: 736 -----------PPKGEKKNVPEKHTREAQKQASEKVS-NKGKRKHKNEDDNRA---SESK 780

Query: 297 KAKEEKLEKCGEDDETIPSEYRLKPATDKD--GKPLLPEPEEKPKPR--------SESEL 346
           K K E     G    +     +   A +KD    P  P P + PK          S+S  
Sbjct: 781 KPKTEDKNSAGHKPSSNRESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSS 840

Query: 347 IDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGT 406
           +   S     +    K S  T K ++++    +  S+ V   +  S  + PP   TL  +
Sbjct: 841 LKSSSNSNKETSGSSKNSSSTSKQKKTEGKTSSS-SKEVKEKAPSSSSNCPPSAPTLDSS 899

Query: 407 VP 408
            P
Sbjct: 900 KP 901



 Score = 33.9 bits (76), Expect = 0.51
 Identities = 28/123 (22%), Positives = 44/123 (35%), Gaps = 4/123 (3%)

Query: 4   TETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVS 63
           +E+K  KTE +  +     S     K    K K+     + P  + D  +     K+ +S
Sbjct: 777 SESKKPKTEDKNSAGHKPSSNRESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTIS 836

Query: 64  RSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPD 123
           +S+    S KS+    K     S    S +      GK     KE K   P+      P 
Sbjct: 837 QSS----SLKSSSNSNKETSGSSKNSSSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPS 892

Query: 124 KPS 126
            P+
Sbjct: 893 APT 895


>gi|109637791 transcription factor-like nuclear regulator [Homo
            sapiens]
          Length = 2624

 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 84/363 (23%), Positives = 150/363 (41%), Gaps = 50/363 (13%)

Query: 223  TAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMS-DQALEALSASLGTRQA 281
            T+  +    E +T+ +++    T R A  P+EK   V  DT+  +  L+A+   +  R+ 
Sbjct: 855  TSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMETGLKAMGREICLREK 914

Query: 282  EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPR 341
             PE+       +D  +  ++ LE+ G          R + +  K+G      PEE  KP 
Sbjct: 915  TPEV-------IDATEEIDKDLEEAG----------RREISPQKNG------PEEV-KPL 950

Query: 342  SESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPA 401
             E E   +L    + S  +EK  + T+ TEE        + + +  T    I      P 
Sbjct: 951  GEVET--DLKATGNESSPREKTPEVTDATEE--------IDKNLEETGRRKISPRENGPE 1000

Query: 402  TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRL 461
             +K   P D +E   ++ G++ +  E    V+D  +E   EE       + E  P +  L
Sbjct: 1001 EVK---PVDEMETDLNATGRESSPREKTPEVIDATEEIDLEET------EREVSPQENGL 1051

Query: 462  EEVKDK-DGKPLLPKESKEQLPPMSEDFLLDALSE---DFSGPQNASSLKFEDAKLAAAI 517
            EEVK   + +  L    ++  P      ++DA+ E   D    +   S +    +    +
Sbjct: 1052 EEVKPLGEMETDLKATGRDSFPRGKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPL 1111

Query: 518  SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA 577
             E+  QT    T     PR+ +    D  + +DK  +  G+R+  P+EN P E K  ++ 
Sbjct: 1112 GEM--QTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEM 1169

Query: 578  KAE 580
            + +
Sbjct: 1170 ETD 1172


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 124/594 (20%), Positives = 224/594 (37%), Gaps = 91/594 (15%)

Query: 5   ETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSL-PKQASDTGSNDAHN----- 58
           E +    + +KK Q  K     +  S+E + K+    K+  PK    +GS+D  +     
Sbjct: 88  EEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLP 147

Query: 59  KKAVSRSAEQQPS------EKSTEPKTKPQDMISAGGESV-AGITAISGKPGDKKKEKKS 111
           KKA  ++ +          ++    K K +  I++ GES       +  + G KK +K  
Sbjct: 148 KKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNK 207

Query: 112 LTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEE 171
             P +   ++ D  S K          I T+   +  ++E       E    +     +E
Sbjct: 208 PGPNIESGNEDDDASFK----------IKTVAQKKAEKKERERKKRDEEKAKLRKLKEKE 257

Query: 172 ---LGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKK 228
               GK++ +   K +E   K E  T      SK       I A  S+    +PTAA   
Sbjct: 258 ELETGKKDQS---KQKESQRKFEEETV----KSKVTVDTGVIPA--SEEKAETPTAAEDD 308

Query: 229 TEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMS--DQALEALSASLGTRQAEPELD 286
            E ++  +  K +           +EKK+   K T+    +AL  L      ++ E E  
Sbjct: 309 NEGDKKKKDKKKKKG---EKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEER 365

Query: 287 LRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESEL 346
           ++ ++E++  + +EE+LE+  + +     E   K    K+GK LL + + + + R+E+ L
Sbjct: 366 IKRLEELEAKRKEEERLEQ-EKRERKKQKEKERKERLKKEGK-LLTKSQREARARAEATL 423

Query: 347 IDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSM--CSIQSAPPEPATLK 404
               ++  +       P K     ++ +   P  +       SM  C+            
Sbjct: 424 KLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCA------------ 471

Query: 405 GTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEV 464
                 AVE +   + +KE  P   +P  ++  E A  +D E +   EET   +     +
Sbjct: 472 ------AVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHI 525

Query: 465 KDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQT 524
           + K+     P+E +E+     ED   +   E+  G    S    ED K++          
Sbjct: 526 EVKEN----PEEEEEEEEEEEEDEESEE-EEEEEGESEGSEGDEEDEKVS---------- 570

Query: 525 PASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 578
                       D   S K LD    K   S    + D D+++  E++  +KAK
Sbjct: 571 ------------DEKDSGKTLDKKPSKEMSS--DSEYDSDDDRTKEERAYDKAK 610



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 123/651 (18%), Positives = 238/651 (36%), Gaps = 110/651 (16%)

Query: 27  EKKSQEGKPKEHTEPKSLPKQASDTGS--NDAHNKKAVSRSAEQQPSEKSTEPKTKPQDM 84
           +K   E   K+  +  +L  +    G+       K    +  E++  +   +   K  + 
Sbjct: 5   QKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE 64

Query: 85  ISAGGESV-AGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 143
           +S   + + A    ++ KP +  +E+ +        SK  K  G+ G   + DD      
Sbjct: 65  LSLEAQGIKADRETVAVKPTENNEEEFT--------SKDKKKKGQKGKKQSFDD-----N 111

Query: 144 GPEETEEENTTY---TGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADS 200
             EE E++++       P+V     S   ++  K       K ++   K +G +    D+
Sbjct: 112 DSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDG-SEEDEDN 170

Query: 201 SKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE 260
           SK I     I++              +K +K+      K +    + S     +   K++
Sbjct: 171 SKKIKERSRINSSGESGDESDEFLQSRKGQKKNQ----KNKPGPNIESGNEDDDASFKIK 226

Query: 261 KDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLK 320
             T++ +  E        R  E +  LR +KE +E +  ++   K  E       E    
Sbjct: 227 --TVAQKKAEKKERERKKRDEE-KAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKS 283

Query: 321 PATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAP 380
             T   G  ++P  EEK +  + +E  D+   D  + + K+K  +  EK +E K      
Sbjct: 284 KVTVDTG--VIPASEEKAETPTAAE--DDNEGDKKKKDKKKKKGEKEEKEKEKKKG---- 335

Query: 381 VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKA 440
                            P  AT+K     +A+  L +   +++ + E+    +++++ K 
Sbjct: 336 -----------------PSKATVKAM--QEALAKLKEEEERQKREEEERIKRLEELEAKR 376

Query: 441 KEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE----------------------SK 478
           KEE+R +  ++E     +   +E   K+GK L   +                      SK
Sbjct: 377 KEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSK 436

Query: 479 EQLP---PMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAS--TTQAGA 533
           + LP   P+ ED     + +     + + S++     L AA+  +    P    T     
Sbjct: 437 DSLPKKRPIYEDKKRKKIPQQLESKEVSESME-----LCAAVEVMEQGVPEKEETPPPVE 491

Query: 534 PPRDTSQSDKDLDDALDKLSDSLGQR---------------QPDPDENKPMEDKVKEKAK 578
           P  +    D  LDD     SD   ++               + + +E +  ED+  E+ +
Sbjct: 492 PEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEE 551

Query: 579 AEHRDKLG----ERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADD 625
            E  +  G    E D+ +  E      D+G+    KP  + S DS+  +DD
Sbjct: 552 EEEGESEGSEGDEEDEKVSDE-----KDSGKTLDKKPSKEMSSDSEYDSDD 597



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 90/411 (21%), Positives = 156/411 (37%), Gaps = 58/411 (14%)

Query: 9   VKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLP---KQASDTGSNDAHNKKAVSRS 65
           +KT  +KK+         EKK +E K ++  + K      K+  +TG  D   +K   R 
Sbjct: 225 IKTVAQKKA---------EKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRK 275

Query: 66  AEQQPSEKSTEPKTKPQDMISAGGESVAGITAISG-KPGDKKKEKKSLTPAVPVESKPDK 124
            E++  +      T    +I A  E     TA      GDKKK+ K        E + +K
Sbjct: 276 FEEETVKSKVTVDT---GVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEK 332

Query: 125 PSGKSGMDA-ALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKY 183
             G S     A+ + +  L   EE ++         + +  +    EE  ++E     K 
Sbjct: 333 KKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQ 392

Query: 184 RE------------LLAKKEGITGPPADSSKPIGPDDAIDALSSD-FTCGSPTAAGKKTE 230
           +E            LL K +      A+++  +     ++  S D      P    KK +
Sbjct: 393 KEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRK 452

Query: 231 K----------EESTEVLKA-----QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSAS 275
           K           ES E+  A     Q         PP E + + + +       EA+++ 
Sbjct: 453 KIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASD 512

Query: 276 LGTRQAE-----------PELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATD 324
             T + E           PE +    +E +E +  EE+ E+ GE + +   E   K + +
Sbjct: 513 EETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDE 572

Query: 325 KD-GKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESK 374
           KD GK L  +P ++    SE +  D+ +++ +R+  K K      + E SK
Sbjct: 573 KDSGKTLDKKPSKEMSSDSEYDSDDDRTKE-ERAYDKAKRRIEKRRLEHSK 622



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 57/289 (19%), Positives = 115/289 (39%), Gaps = 24/289 (8%)

Query: 409 DDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEE----DREKLGEK-EETIPPDYRLEE 463
           DD ++ L +   + +    D + V  K  E  +EE    D++K G+K ++    D   EE
Sbjct: 56  DDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEE 115

Query: 464 VKDKDGKPLLPKESK-EQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVS 522
           ++DKD K     + K E      +D   + L +   G    S+ K++ ++     S+ + 
Sbjct: 116 LEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIK 175

Query: 523 QTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQP-----DPDENKPMEDKVKEKA 577
           +     ++  +      +SD+ L     +  +   +  P     + D++   + K   + 
Sbjct: 176 E----RSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQK 231

Query: 578 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPAD---------DQDP 628
           KAE +++  ++ D    + R L +    +   K  +K+ E  +K  +         D   
Sbjct: 232 KAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGV 291

Query: 629 IDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTT 677
           I A     ++  +  + ++   K K KK     K  K   K K  +K T
Sbjct: 292 IPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKAT 340



 Score = 37.0 bits (84), Expect = 0.061
 Identities = 40/168 (23%), Positives = 77/168 (45%), Gaps = 26/168 (15%)

Query: 537 DTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY 596
           D+++ D DLD    ++  +   ++ +P ++K  + K K+K   +  D L E ++ +  E 
Sbjct: 11  DSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE-LSLEA 69

Query: 597 RHL-----------LDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTET 645
           + +            ++N ++   K   KK +  KK + D +  + L  D DS       
Sbjct: 70  QGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELE-DKDS------K 122

Query: 646 SQNTAKDKCKKAASS------SKAPKNG-GKAKDSAKTTEETSKPKDD 686
           S+ TAK K +  + S      +K PK   GKA+ S K  + + + +D+
Sbjct: 123 SKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDN 170


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 146/711 (20%), Positives = 230/711 (32%), Gaps = 65/711 (9%)

Query: 4   TETKAVKTEPEKKSQSTKLSVVHEKKSQEG-KPKEHTEPKSLPKQASDTGSNDAHNKKAV 62
           T  K   T+ ++K+ S K +   EK S +   P      K  PK  + T        K  
Sbjct: 157 TTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEP 216

Query: 63  SRSAEQQPSEKSTEPKTKPQDMISAGG---ESVAGITAISGKPGDKK------KEKKSLT 113
           + +  ++P+  ST PK      I +     +  A  T  S     K+      KE    T
Sbjct: 217 TPTTPKEPA--STTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT 274

Query: 114 PAVPVESKPDKPSG---KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIE 170
           P  P  +   +P+    KS      +    T   P  T  +    T P+   P +     
Sbjct: 275 PKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPA 334

Query: 171 ELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTE 230
              K      PK     A K+     P + + P  P +     + + +  +P      T 
Sbjct: 335 PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA-PTTPKEPAPTTTKEPSPTTPKEPAPTTT 393

Query: 231 KEESTEVLKAQSAGTVRSAAPPQEKKRKVEKD----TMSDQALEALSASLGTRQAEPELD 286
           K   T   +     T  +   P+E      K+    T  + A         T   EP   
Sbjct: 394 KSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 453

Query: 287 LRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPR 341
             + KE      K+       E   T P E    P T K   P  PE       EKP P 
Sbjct: 454 --TPKEPAPTTTKKPAPTTPKEPAPTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPT 509

Query: 342 SESELIDELSEDFDRSECKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEP 400
           +  EL     E+         P+ P E    + KAAAP    E    T      + P EP
Sbjct: 510 TPEELAPTTPEE-------PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP 562

Query: 401 A--TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 458
           A  T K T P    +  A +  K+ A     KP   ++     +E      +K     P 
Sbjct: 563 APTTPKETAPTTP-KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP- 620

Query: 459 YRLEEVKDKDGKPLLPKES-----KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKL 513
                   K   P  PKE      KE  P   +      L E    P   +  K    +L
Sbjct: 621 --------KGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKEL 668

Query: 514 AAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKV 573
           A   ++  + T +       P      + K+      K         P P  ++      
Sbjct: 669 APTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTT 728

Query: 574 KEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDA 631
            ++    H+      D++ P           ++ P +P  PT K+  + KP       D 
Sbjct: 729 TKEPTTIHKSP----DESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDK 784

Query: 632 LSG-DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETS 681
            +  DL + P TT  +    K+       ++++       + ++ TT++T+
Sbjct: 785 TTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTT 835



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 101/497 (20%), Positives = 164/497 (32%), Gaps = 36/497 (7%)

Query: 202 KPIGPDDAIDALSS-DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE 260
           KP   D+A   L + DF   +P  +  +  K  ++  +        R + PP     K  
Sbjct: 81  KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 140

Query: 261 KDTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 319
             T++ +  +E    +   +Q   +      KE   +  + + +EK    D    S+   
Sbjct: 141 SLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLA 195

Query: 320 KPATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAA 376
           KP    +     P L  P+E P P +  E      ++   +  K  P+ P E    +  +
Sbjct: 196 KPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKS 254

Query: 377 APAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKV 436
           AP    E    T+     + P EPA      P       A +  K+ A     KP     
Sbjct: 255 APTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 314

Query: 437 KEKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLPPMSEDFLL 490
           KE A    +E      +E  P          K+  P  PK+      KE  P   ++   
Sbjct: 315 KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAP 374

Query: 491 DALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS-QSDKDLDD 547
               E       + +   E A      +   ++ PA TT   AP  P++ S  + K+   
Sbjct: 375 TTTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 428

Query: 548 ALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQD 606
              K       ++P P   K P     KE A    +    +   T P E           
Sbjct: 429 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAPTTPKETAP 484

Query: 607 KPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKN 666
              K  T  + +   P   + P      +L   P+T E    T  ++       + AP  
Sbjct: 485 TTPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTTPKAAAPNT 542

Query: 667 GGKAKDSAKTTEETSKP 683
               K+ A TT +   P
Sbjct: 543 ---PKEPAPTTPKEPAP 556



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 57/267 (21%), Positives = 93/267 (34%), Gaps = 15/267 (5%)

Query: 194 TGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 253
           T P   ++KPI P  ++   S      S T   + T + + T     Q++   +      
Sbjct: 114 TSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSA 173

Query: 254 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 313
           ++ + +EK +  D A  +   +  T +AE      ++    E      K        E  
Sbjct: 174 KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 233

Query: 314 PSEYRLKPATDKDGKPL------------LPEPEEKPKPRSESELIDELSEDFDRSECKE 361
           P+  +  P T K+  P              P   ++P P +  E     +++   +  K 
Sbjct: 234 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS 293

Query: 362 KPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA-TLKGTVPDDAVEALADSL 419
            P+ P E    + K  AP    E    T      + P EPA T K   P    E  A + 
Sbjct: 294 APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP-APTA 352

Query: 420 GKKEADPEDGKPVMDKVKEKAKEEDRE 446
            KK A     +P     KE A    +E
Sbjct: 353 PKKPAPTTPKEPAPTTPKEPAPTTTKE 379



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 110/530 (20%), Positives = 179/530 (33%), Gaps = 85/530 (16%)

Query: 4    TETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK-SLPKQASDTGSNDAH--NKK 60
            T  +   T PE+ + +T  +       +E  P    EP  + PK+ + T   +      K
Sbjct: 518  TPEEPTPTTPEEPAPTTPKAAA-PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPK 576

Query: 61   AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKP----GDKKKEKKSLTPAV 116
              + +  ++P+  +T  K  P+++     +     T     P    G      K   P  
Sbjct: 577  GTAPTTLKEPAP-TTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTT 635

Query: 117  PVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPE--VSDPMSSTYIEELGK 174
            P E  P  P G +      +    T   P   E   TT  GP    SD  + T  +E   
Sbjct: 636  PKEPAPTTPKG-TAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP 694

Query: 175  REVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEES 234
               T P +      KK   T P         P      +S+  T   PT   K  +  ES
Sbjct: 695  ---TTPKEPAPTTPKKPAPTTPET-------PPPTTSEVSTPTTTKEPTTIHKSPD--ES 742

Query: 235  TEVLKAQSAGTVRSAAP-----PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRS 289
            T  L A+        +P     P  K     K  M+  A +  +          E DLR+
Sbjct: 743  TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTT----------ERDLRT 792

Query: 290  IKEVDEAKAKEEKLEKCGEDDETIPSEY-----RLKPATDKDGKP----------LLPEP 334
              E   A  K  K E     ++T  S+      ++   T +D  P          L P+ 
Sbjct: 793  TPETTTAAPKMTK-ETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKV 851

Query: 335  EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 394
                K  + +E++++           E+ +KP ++   SKA  P P           S +
Sbjct: 852  TTTKKTITTTEIMNK----------PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTK 901

Query: 395  -----------SAPPEPATLKGTVPD-DAVEALADSLGKKEADPEDGKPVMDKVKEKAKE 442
                          P P  +  T+P+ +    +A+++ +    P    P    V+   K 
Sbjct: 902  KPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKS 960

Query: 443  EDREKLGEKEET-----IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSED 487
            ED    G + ET      P  +  E   D D  P +P +     P +S++
Sbjct: 961  EDAG--GAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDE 1008



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 54/255 (21%), Positives = 93/255 (36%), Gaps = 21/255 (8%)

Query: 438 EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDF 497
           E+ +E D +   +K +   PDY     + KD K    K+     PP+        + E  
Sbjct: 38  ERGRECDCDAQCKKYDKCCPDYESFCAEVKDNKKNRTKKKPTPKPPV--------VDEAG 89

Query: 498 SGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDT--SQSDKDLDDALDKLSDS 555
           SG  N    K      +      VS +P  TT     PR +    SD   + +L    ++
Sbjct: 90  SGLDN-GDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKET 148

Query: 556 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDT--IPPEYRHLLDDNGQ-DKPVKPP 612
             + +     NK      KEK  +    +  E+     + P  + L     + +   K P
Sbjct: 149 TVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP 208

Query: 613 TKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKC----KKAASSSKAPKNGG 668
              +     P   ++P  A +   +  P+T +++  T K+      K A ++ K P    
Sbjct: 209 ALTTPKEPTPTTPKEP--ASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA-PT 265

Query: 669 KAKDSAKTTEETSKP 683
             K+ A TT +   P
Sbjct: 266 TTKEPAPTTPKEPAP 280


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 146/711 (20%), Positives = 230/711 (32%), Gaps = 65/711 (9%)

Query: 4   TETKAVKTEPEKKSQSTKLSVVHEKKSQEG-KPKEHTEPKSLPKQASDTGSNDAHNKKAV 62
           T  K   T+ ++K+ S K +   EK S +   P      K  PK  + T        K  
Sbjct: 198 TTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEP 257

Query: 63  SRSAEQQPSEKSTEPKTKPQDMISAGG---ESVAGITAISGKPGDKK------KEKKSLT 113
           + +  ++P+  ST PK      I +     +  A  T  S     K+      KE    T
Sbjct: 258 TPTTPKEPA--STTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT 315

Query: 114 PAVPVESKPDKPSG---KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIE 170
           P  P  +   +P+    KS      +    T   P  T  +    T P+   P +     
Sbjct: 316 PKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPA 375

Query: 171 ELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTE 230
              K      PK     A K+     P + + P  P +     + + +  +P      T 
Sbjct: 376 PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA-PTTPKEPAPTTTKEPSPTTPKEPAPTTT 434

Query: 231 KEESTEVLKAQSAGTVRSAAPPQEKKRKVEKD----TMSDQALEALSASLGTRQAEPELD 286
           K   T   +     T  +   P+E      K+    T  + A         T   EP   
Sbjct: 435 KSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 494

Query: 287 LRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPR 341
             + KE      K+       E   T P E    P T K   P  PE       EKP P 
Sbjct: 495 --TPKEPAPTTTKKPAPTTPKEPAPTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPT 550

Query: 342 SESELIDELSEDFDRSECKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEP 400
           +  EL     E+         P+ P E    + KAAAP    E    T      + P EP
Sbjct: 551 TPEELAPTTPEE-------PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP 603

Query: 401 A--TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 458
           A  T K T P    +  A +  K+ A     KP   ++     +E      +K     P 
Sbjct: 604 APTTPKETAPTTP-KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP- 661

Query: 459 YRLEEVKDKDGKPLLPKES-----KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKL 513
                   K   P  PKE      KE  P   +      L E    P   +  K    +L
Sbjct: 662 --------KGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKEL 709

Query: 514 AAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKV 573
           A   ++  + T +       P      + K+      K         P P  ++      
Sbjct: 710 APTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTT 769

Query: 574 KEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDA 631
            ++    H+      D++ P           ++ P +P  PT K+  + KP       D 
Sbjct: 770 TKEPTTIHKSP----DESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDK 825

Query: 632 LSG-DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETS 681
            +  DL + P TT  +    K+       ++++       + ++ TT++T+
Sbjct: 826 TTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTT 876



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 101/497 (20%), Positives = 164/497 (32%), Gaps = 36/497 (7%)

Query: 202 KPIGPDDAIDALSS-DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE 260
           KP   D+A   L + DF   +P  +  +  K  ++  +        R + PP     K  
Sbjct: 122 KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 181

Query: 261 KDTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 319
             T++ +  +E    +   +Q   +      KE   +  + + +EK    D    S+   
Sbjct: 182 SLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLA 236

Query: 320 KPATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAA 376
           KP    +     P L  P+E P P +  E      ++   +  K  P+ P E    +  +
Sbjct: 237 KPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKS 295

Query: 377 APAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKV 436
           AP    E    T+     + P EPA      P       A +  K+ A     KP     
Sbjct: 296 APTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 355

Query: 437 KEKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLPPMSEDFLL 490
           KE A    +E      +E  P          K+  P  PK+      KE  P   ++   
Sbjct: 356 KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAP 415

Query: 491 DALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS-QSDKDLDD 547
               E       + +   E A      +   ++ PA TT   AP  P++ S  + K+   
Sbjct: 416 TTTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 469

Query: 548 ALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQD 606
              K       ++P P   K P     KE A    +    +   T P E           
Sbjct: 470 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAPTTPKETAP 525

Query: 607 KPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKN 666
              K  T  + +   P   + P      +L   P+T E    T  ++       + AP  
Sbjct: 526 TTPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTTPKAAAPNT 583

Query: 667 GGKAKDSAKTTEETSKP 683
               K+ A TT +   P
Sbjct: 584 ---PKEPAPTTPKEPAP 597



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 57/267 (21%), Positives = 93/267 (34%), Gaps = 15/267 (5%)

Query: 194 TGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 253
           T P   ++KPI P  ++   S      S T   + T + + T     Q++   +      
Sbjct: 155 TSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSA 214

Query: 254 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 313
           ++ + +EK +  D A  +   +  T +AE      ++    E      K        E  
Sbjct: 215 KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 274

Query: 314 PSEYRLKPATDKDGKPL------------LPEPEEKPKPRSESELIDELSEDFDRSECKE 361
           P+  +  P T K+  P              P   ++P P +  E     +++   +  K 
Sbjct: 275 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS 334

Query: 362 KPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA-TLKGTVPDDAVEALADSL 419
            P+ P E    + K  AP    E    T      + P EPA T K   P    E  A + 
Sbjct: 335 APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP-APTA 393

Query: 420 GKKEADPEDGKPVMDKVKEKAKEEDRE 446
            KK A     +P     KE A    +E
Sbjct: 394 PKKPAPTTPKEPAPTTPKEPAPTTTKE 420



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 110/530 (20%), Positives = 179/530 (33%), Gaps = 85/530 (16%)

Query: 4    TETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK-SLPKQASDTGSNDAH--NKK 60
            T  +   T PE+ + +T  +       +E  P    EP  + PK+ + T   +      K
Sbjct: 559  TPEEPTPTTPEEPAPTTPKAAA-PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPK 617

Query: 61   AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKP----GDKKKEKKSLTPAV 116
              + +  ++P+  +T  K  P+++     +     T     P    G      K   P  
Sbjct: 618  GTAPTTLKEPAP-TTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTT 676

Query: 117  PVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPE--VSDPMSSTYIEELGK 174
            P E  P  P G +      +    T   P   E   TT  GP    SD  + T  +E   
Sbjct: 677  PKEPAPTTPKG-TAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP 735

Query: 175  REVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEES 234
               T P +      KK   T P         P      +S+  T   PT   K  +  ES
Sbjct: 736  ---TTPKEPAPTTPKKPAPTTPET-------PPPTTSEVSTPTTTKEPTTIHKSPD--ES 783

Query: 235  TEVLKAQSAGTVRSAAP-----PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRS 289
            T  L A+        +P     P  K     K  M+  A +  +          E DLR+
Sbjct: 784  TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTT----------ERDLRT 833

Query: 290  IKEVDEAKAKEEKLEKCGEDDETIPSEY-----RLKPATDKDGKP----------LLPEP 334
              E   A  K  K E     ++T  S+      ++   T +D  P          L P+ 
Sbjct: 834  TPETTTAAPKMTK-ETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKV 892

Query: 335  EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 394
                K  + +E++++           E+ +KP ++   SKA  P P           S +
Sbjct: 893  TTTKKTITTTEIMNK----------PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTK 942

Query: 395  -----------SAPPEPATLKGTVPD-DAVEALADSLGKKEADPEDGKPVMDKVKEKAKE 442
                          P P  +  T+P+ +    +A+++ +    P    P    V+   K 
Sbjct: 943  KPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKS 1001

Query: 443  EDREKLGEKEET-----IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSED 487
            ED    G + ET      P  +  E   D D  P +P +     P +S++
Sbjct: 1002 EDAG--GAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDE 1049



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 54/255 (21%), Positives = 93/255 (36%), Gaps = 21/255 (8%)

Query: 438 EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDF 497
           E+ +E D +   +K +   PDY     + KD K    K+     PP+        + E  
Sbjct: 79  ERGRECDCDAQCKKYDKCCPDYESFCAEVKDNKKNRTKKKPTPKPPV--------VDEAG 130

Query: 498 SGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDT--SQSDKDLDDALDKLSDS 555
           SG  N    K      +      VS +P  TT     PR +    SD   + +L    ++
Sbjct: 131 SGLDN-GDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKET 189

Query: 556 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDT--IPPEYRHLLDDNGQ-DKPVKPP 612
             + +     NK      KEK  +    +  E+     + P  + L     + +   K P
Sbjct: 190 TVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP 249

Query: 613 TKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKC----KKAASSSKAPKNGG 668
              +     P   ++P  A +   +  P+T +++  T K+      K A ++ K P    
Sbjct: 250 ALTTPKEPTPTTPKEP--ASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA-PT 306

Query: 669 KAKDSAKTTEETSKP 683
             K+ A TT +   P
Sbjct: 307 TTKEPAPTTPKEPAP 321


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 146/711 (20%), Positives = 230/711 (32%), Gaps = 65/711 (9%)

Query: 4   TETKAVKTEPEKKSQSTKLSVVHEKKSQEG-KPKEHTEPKSLPKQASDTGSNDAHNKKAV 62
           T  K   T+ ++K+ S K +   EK S +   P      K  PK  + T        K  
Sbjct: 250 TTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEP 309

Query: 63  SRSAEQQPSEKSTEPKTKPQDMISAGG---ESVAGITAISGKPGDKK------KEKKSLT 113
           + +  ++P+  ST PK      I +     +  A  T  S     K+      KE    T
Sbjct: 310 TPTTPKEPA--STTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT 367

Query: 114 PAVPVESKPDKPSG---KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIE 170
           P  P  +   +P+    KS      +    T   P  T  +    T P+   P +     
Sbjct: 368 PKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPA 427

Query: 171 ELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTE 230
              K      PK     A K+     P + + P  P +     + + +  +P      T 
Sbjct: 428 PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA-PTTPKEPAPTTTKEPSPTTPKEPAPTTT 486

Query: 231 KEESTEVLKAQSAGTVRSAAPPQEKKRKVEKD----TMSDQALEALSASLGTRQAEPELD 286
           K   T   +     T  +   P+E      K+    T  + A         T   EP   
Sbjct: 487 KSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 546

Query: 287 LRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPR 341
             + KE      K+       E   T P E    P T K   P  PE       EKP P 
Sbjct: 547 --TPKEPAPTTTKKPAPTTPKEPAPTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPT 602

Query: 342 SESELIDELSEDFDRSECKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEP 400
           +  EL     E+         P+ P E    + KAAAP    E    T      + P EP
Sbjct: 603 TPEELAPTTPEE-------PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP 655

Query: 401 A--TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 458
           A  T K T P    +  A +  K+ A     KP   ++     +E      +K     P 
Sbjct: 656 APTTPKETAPTTP-KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP- 713

Query: 459 YRLEEVKDKDGKPLLPKES-----KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKL 513
                   K   P  PKE      KE  P   +      L E    P   +  K    +L
Sbjct: 714 --------KGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKEL 761

Query: 514 AAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKV 573
           A   ++  + T +       P      + K+      K         P P  ++      
Sbjct: 762 APTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTT 821

Query: 574 KEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDA 631
            ++    H+      D++ P           ++ P +P  PT K+  + KP       D 
Sbjct: 822 TKEPTTIHKSP----DESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDK 877

Query: 632 LSG-DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETS 681
            +  DL + P TT  +    K+       ++++       + ++ TT++T+
Sbjct: 878 TTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTT 928



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 124/625 (19%), Positives = 209/625 (33%), Gaps = 60/625 (9%)

Query: 74  STEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDA 133
           ++ P +K     S   +++   T  S KP +KKK KK     +  E   ++ S     ++
Sbjct: 70  TSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKK----VIESEEITEEHSVSENQES 125

Query: 134 ALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKR-EVTIPPKYRELLAKKEG 192
           +             +   +++ T  ++    +S    EL K+ +V    K R    KK+ 
Sbjct: 126 S-----------SSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNR---TKKKP 171

Query: 193 ITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPP 252
              PP       G D+       DF   +P  +  +  K  ++  +        R + PP
Sbjct: 172 TPKPPVVDEAGSGLDNG------DFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPP 225

Query: 253 QEKKRKVEKDTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDE 311
                K    T++ +  +E    +   +Q   +      KE   +  + + +EK    D 
Sbjct: 226 NSDTSKETSLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDL 280

Query: 312 TIPSEYRLKPATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTE 368
              S+   KP    +     P L  P+E P P +  E      ++   +  K  P+ P E
Sbjct: 281 APTSKVLAKPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKE 339

Query: 369 KTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPED 428
               +  +AP    E    T+     + P EPA      P       A +  K+ A    
Sbjct: 340 PAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTP 399

Query: 429 GKPVMDKVKEKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLP 482
            KP     KE A    +E      +E  P          K+  P  PK+      KE  P
Sbjct: 400 KKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAP 459

Query: 483 PMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS- 539
              ++       E       + +   E A      +   ++ PA TT   AP  P++ S 
Sbjct: 460 TTPKEPAPTTTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSP 513

Query: 540 QSDKDLDDALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRH 598
            + K+      K       ++P P   K P     KE A    +    +   T P E   
Sbjct: 514 TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAP 569

Query: 599 LLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAA 658
                      K  T  + +   P   + P      +L   P+T E    T  ++     
Sbjct: 570 TTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTT 627

Query: 659 SSSKAPKNGGKAKDSAKTTEETSKP 683
             + AP      K+ A TT +   P
Sbjct: 628 PKAAAPNT---PKEPAPTTPKEPAP 649



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 110/530 (20%), Positives = 179/530 (33%), Gaps = 85/530 (16%)

Query: 4    TETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK-SLPKQASDTGSNDAH--NKK 60
            T  +   T PE+ + +T  +       +E  P    EP  + PK+ + T   +      K
Sbjct: 611  TPEEPTPTTPEEPAPTTPKAAA-PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPK 669

Query: 61   AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKP----GDKKKEKKSLTPAV 116
              + +  ++P+  +T  K  P+++     +     T     P    G      K   P  
Sbjct: 670  GTAPTTLKEPAP-TTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTT 728

Query: 117  PVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPE--VSDPMSSTYIEELGK 174
            P E  P  P G +      +    T   P   E   TT  GP    SD  + T  +E   
Sbjct: 729  PKEPAPTTPKG-TAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP 787

Query: 175  REVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEES 234
               T P +      KK   T P         P      +S+  T   PT   K  +  ES
Sbjct: 788  ---TTPKEPAPTTPKKPAPTTPET-------PPPTTSEVSTPTTTKEPTTIHKSPD--ES 835

Query: 235  TEVLKAQSAGTVRSAAP-----PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRS 289
            T  L A+        +P     P  K     K  M+  A +  +          E DLR+
Sbjct: 836  TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTT----------ERDLRT 885

Query: 290  IKEVDEAKAKEEKLEKCGEDDETIPSEY-----RLKPATDKDGKP----------LLPEP 334
              E   A  K  K E     ++T  S+      ++   T +D  P          L P+ 
Sbjct: 886  TPETTTAAPKMTK-ETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKV 944

Query: 335  EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 394
                K  + +E++++           E+ +KP ++   SKA  P P           S +
Sbjct: 945  TTTKKTITTTEIMNK----------PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTK 994

Query: 395  -----------SAPPEPATLKGTVPD-DAVEALADSLGKKEADPEDGKPVMDKVKEKAKE 442
                          P P  +  T+P+ +    +A+++ +    P    P    V+   K 
Sbjct: 995  KPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKS 1053

Query: 443  EDREKLGEKEET-----IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSED 487
            ED    G + ET      P  +  E   D D  P +P +     P +S++
Sbjct: 1054 EDAG--GAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDE 1101


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 146/711 (20%), Positives = 230/711 (32%), Gaps = 65/711 (9%)

Query: 4   TETKAVKTEPEKKSQSTKLSVVHEKKSQEG-KPKEHTEPKSLPKQASDTGSNDAHNKKAV 62
           T  K   T+ ++K+ S K +   EK S +   P      K  PK  + T        K  
Sbjct: 291 TTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEP 350

Query: 63  SRSAEQQPSEKSTEPKTKPQDMISAGG---ESVAGITAISGKPGDKK------KEKKSLT 113
           + +  ++P+  ST PK      I +     +  A  T  S     K+      KE    T
Sbjct: 351 TPTTPKEPA--STTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT 408

Query: 114 PAVPVESKPDKPSG---KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIE 170
           P  P  +   +P+    KS      +    T   P  T  +    T P+   P +     
Sbjct: 409 PKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPA 468

Query: 171 ELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTE 230
              K      PK     A K+     P + + P  P +     + + +  +P      T 
Sbjct: 469 PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA-PTTPKEPAPTTTKEPSPTTPKEPAPTTT 527

Query: 231 KEESTEVLKAQSAGTVRSAAPPQEKKRKVEKD----TMSDQALEALSASLGTRQAEPELD 286
           K   T   +     T  +   P+E      K+    T  + A         T   EP   
Sbjct: 528 KSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 587

Query: 287 LRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP-----EEKPKPR 341
             + KE      K+       E   T P E    P T K   P  PE       EKP P 
Sbjct: 588 --TPKEPAPTTTKKPAPTTPKEPAPTTPKE--TAPTTPKKLTPTTPEKLAPTTPEKPAPT 643

Query: 342 SESELIDELSEDFDRSECKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEP 400
           +  EL     E+         P+ P E    + KAAAP    E    T      + P EP
Sbjct: 644 TPEELAPTTPEE-------PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP 696

Query: 401 A--TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 458
           A  T K T P    +  A +  K+ A     KP   ++     +E      +K     P 
Sbjct: 697 APTTPKETAPTTP-KGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTP- 754

Query: 459 YRLEEVKDKDGKPLLPKES-----KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKL 513
                   K   P  PKE      KE  P   +      L E    P   +  K    +L
Sbjct: 755 --------KGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKE----PAPTTPKKPAPKEL 802

Query: 514 AAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKV 573
           A   ++  + T +       P      + K+      K         P P  ++      
Sbjct: 803 APTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTT 862

Query: 574 KEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKP--PTKKSEDSKKPADDQDPIDA 631
            ++    H+      D++ P           ++ P +P  PT K+  + KP       D 
Sbjct: 863 TKEPTTIHKSP----DESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDK 918

Query: 632 LSG-DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETS 681
            +  DL + P TT  +    K+       ++++       + ++ TT++T+
Sbjct: 919 TTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTT 969



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 124/625 (19%), Positives = 209/625 (33%), Gaps = 60/625 (9%)

Query: 74  STEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDA 133
           ++ P +K     S   +++   T  S KP +KKK KK     +  E   ++ S     ++
Sbjct: 111 TSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKK----VIESEEITEEHSVSENQES 166

Query: 134 ALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKR-EVTIPPKYRELLAKKEG 192
           +             +   +++ T  ++    +S    EL K+ +V    K R    KK+ 
Sbjct: 167 S-----------SSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNR---TKKKP 212

Query: 193 ITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPP 252
              PP       G D+       DF   +P  +  +  K  ++  +        R + PP
Sbjct: 213 TPKPPVVDEAGSGLDNG------DFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPP 266

Query: 253 QEKKRKVEKDTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDE 311
                K    T++ +  +E    +   +Q   +      KE   +  + + +EK    D 
Sbjct: 267 NSDTSKETSLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDL 321

Query: 312 TIPSEYRLKPATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTE 368
              S+   KP    +     P L  P+E P P +  E      ++   +  K  P+ P E
Sbjct: 322 APTSKVLAKPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKE 380

Query: 369 KTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPED 428
               +  +AP    E    T+     + P EPA      P       A +  K+ A    
Sbjct: 381 PAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTP 440

Query: 429 GKPVMDKVKEKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLP 482
            KP     KE A    +E      +E  P          K+  P  PK+      KE  P
Sbjct: 441 KKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAP 500

Query: 483 PMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS- 539
              ++       E       + +   E A      +   ++ PA TT   AP  P++ S 
Sbjct: 501 TTPKEPAPTTTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSP 554

Query: 540 QSDKDLDDALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRH 598
            + K+      K       ++P P   K P     KE A    +    +   T P E   
Sbjct: 555 TTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAP 610

Query: 599 LLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAA 658
                      K  T  + +   P   + P      +L   P+T E    T  ++     
Sbjct: 611 TTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTT 668

Query: 659 SSSKAPKNGGKAKDSAKTTEETSKP 683
             + AP      K+ A TT +   P
Sbjct: 669 PKAAAPNT---PKEPAPTTPKEPAP 690



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 110/530 (20%), Positives = 179/530 (33%), Gaps = 85/530 (16%)

Query: 4    TETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK-SLPKQASDTGSNDAH--NKK 60
            T  +   T PE+ + +T  +       +E  P    EP  + PK+ + T   +      K
Sbjct: 652  TPEEPTPTTPEEPAPTTPKAAA-PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPK 710

Query: 61   AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKP----GDKKKEKKSLTPAV 116
              + +  ++P+  +T  K  P+++     +     T     P    G      K   P  
Sbjct: 711  GTAPTTLKEPAP-TTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTT 769

Query: 117  PVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPE--VSDPMSSTYIEELGK 174
            P E  P  P G +      +    T   P   E   TT  GP    SD  + T  +E   
Sbjct: 770  PKEPAPTTPKG-TAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP 828

Query: 175  REVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEES 234
               T P +      KK   T P         P      +S+  T   PT   K  +  ES
Sbjct: 829  ---TTPKEPAPTTPKKPAPTTPET-------PPPTTSEVSTPTTTKEPTTIHKSPD--ES 876

Query: 235  TEVLKAQSAGTVRSAAP-----PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRS 289
            T  L A+        +P     P  K     K  M+  A +  +          E DLR+
Sbjct: 877  TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTT----------ERDLRT 926

Query: 290  IKEVDEAKAKEEKLEKCGEDDETIPSEY-----RLKPATDKDGKP----------LLPEP 334
              E   A  K  K E     ++T  S+      ++   T +D  P          L P+ 
Sbjct: 927  TPETTTAAPKMTK-ETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKV 985

Query: 335  EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 394
                K  + +E++++           E+ +KP ++   SKA  P P           S +
Sbjct: 986  TTTKKTITTTEIMNK----------PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTK 1035

Query: 395  -----------SAPPEPATLKGTVPD-DAVEALADSLGKKEADPEDGKPVMDKVKEKAKE 442
                          P P  +  T+P+ +    +A+++ +    P    P    V+   K 
Sbjct: 1036 KPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKS 1094

Query: 443  EDREKLGEKEET-----IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSED 487
            ED    G + ET      P  +  E   D D  P +P +     P +S++
Sbjct: 1095 EDAG--GAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDE 1142


>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
          Length = 2468

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 163/716 (22%), Positives = 254/716 (35%), Gaps = 150/716 (20%)

Query: 4    TETKAVKTE---PEKKSQSTKLSVVHEKKSQEGKPK---EHTEPKSLPKQASDTGSNDAH 57
            TETK   TE   P K+  S   + V EK++ + KPK   E T  K    +  D       
Sbjct: 596  TETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEK 655

Query: 58   NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSL---TP 114
             KK V++  ++ P +K  +PK           E V        K  +KK+ KK +   TP
Sbjct: 656  PKKEVAKKEDKTPIKKEEKPKK----------EEVKKEVKKEIKKEEKKEPKKEVKKETP 705

Query: 115  AVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGK 174
               V+ +  K   K                 EE E +      P+ +   SST + E  K
Sbjct: 706  PKEVKKEVKKEEKKEVKK-------------EEKEPKKEIKKLPKDAKK-SSTPLSEAKK 751

Query: 175  REVTIP--PKYRELLAKKEGITGPPADSSKPI---GPDDAIDALSSDFTCGSPTAA---- 225
                 P  PK  E + K     G P +  K         A +A+++    G+ TAA    
Sbjct: 752  PAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAA 811

Query: 226  --------GKKTEKEEST-----------EVLKAQSAGTVRSAAPP-----QEKKRKVEK 261
                     K+ E E S            E LKA+     +   P       E+K K  +
Sbjct: 812  AGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETE 871

Query: 262  DTMSDQALEALSASLGTRQAEPE--LDLRSIKEVDEAKAKEEKLEKCGEDD-ETIPSEYR 318
               +    +    + G  ++  E         E ++   + E +EK G DD E    E  
Sbjct: 872  PVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGA 931

Query: 319  LKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSEC-KEKPSKPTEKTEESKAAA 377
                + + G     + EEK    +E+E  +E  ED +   C       PTE  E +KA A
Sbjct: 932  GFEESSETG-----DYEEK----AETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEA 982

Query: 378  PAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVK 437
             A + E   R S+ S                D A E + +++ K EA+  +         
Sbjct: 983  DAYIREK--RESVASGD--------------DRAEEDMDEAIEKGEAEQSE--------- 1017

Query: 438  EKAKEEDREKLGEKEETIPPDYRLEE----VKDKDGKPLLPKESKEQLPPMSEDFLLDAL 493
            E+A EED+ +   +EE  P     E+    V DK  +    +E    L   ++      L
Sbjct: 1018 EEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQ-----L 1072

Query: 494  SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLS 553
                 G + ASS+  E                  T   G+    T+  +++ +D  ++ +
Sbjct: 1073 GAQSPGREPASSIHDE------------------TLPGGSESEATASDEENREDQPEEFT 1114

Query: 554  DSLGQRQ--------PDP-DENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNG 604
             + G  Q        P P DE     D + ++   E  +   +    I  +Y   L    
Sbjct: 1115 ATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNI-TKYESSLYSQE 1173

Query: 605  QDKP--VKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAA 658
              KP  V P    SE SK  A D         D ++  ST     +  +DK  ++A
Sbjct: 1174 YSKPADVTPLNGFSEGSKTDATD-------GKDYNASASTISPPSSMEEDKFSRSA 1222



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 109/521 (20%), Positives = 192/521 (36%), Gaps = 95/521 (18%)

Query: 222  PTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKV-----------------EKDTM 264
            P+ + +K  KEE+ EV K           P  E K KV                 EK+  
Sbjct: 553  PSKSVRKESKEETPEVTKVNHV----EKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVP 608

Query: 265  SDQALEALSASLGTRQA---EPELDLRS-------IKEVDEAKAKEEKLEKCGEDDETIP 314
            S +    + A +  +QA   +P+            +K  D+ + KE+  ++  + ++  P
Sbjct: 609  SKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTP 668

Query: 315  SEYRLKPATDKDGKPLLPE--PEEKPKPRSESEL---IDELSEDFDRSECKE------KP 363
             +   KP  ++  K +  E   EEK +P+ E +      E+ ++  + E KE      +P
Sbjct: 669  IKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEP 728

Query: 364  SKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKE 423
             K  +K  +    +  P+SEA              +PA LK  VP        DS+   +
Sbjct: 729  KKEIKKLPKDAKKSSTPLSEA-------------KKPAALKPKVPKKEESVKKDSVAAGK 775

Query: 424  ADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPP 483
               E GK  + K + KA E     +G    T               K L   E++  L  
Sbjct: 776  -PKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKEL---EAERSLMS 831

Query: 484  MSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI---------SEVVSQTPASTTQAGAP 534
              ED     L++DF        LK E+  +   I          E + +T          
Sbjct: 832  SPED-----LTKDF------EELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQK 880

Query: 535  PRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPME----DKVK----EKAKAEHRDKLG 586
             R+ ++   +  D     ++  G+ +  P+E +P+E    D ++    E A  E   + G
Sbjct: 881  EREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETG 940

Query: 587  ERDDTIPPEYRHLLDDNGQD-----KPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPS 641
            + ++    E     +++G++          PT+  E +K  AD    I      + S   
Sbjct: 941  DYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAY--IREKRESVASGDD 998

Query: 642  TTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSK 682
              E   + A +K +   S  +A +   KA+D+ +   E  K
Sbjct: 999  RAEEDMDEAIEKGEAEQSEEEADEE-DKAEDAREEEYEPEK 1038



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 95/453 (20%), Positives = 169/453 (37%), Gaps = 63/453 (13%)

Query: 3    PTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAV 62
            P +    +T P++  +  K     E K +E +PK+  E K LPK A  + +  +  KK  
Sbjct: 696  PKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKK--EIKKLPKDAKKSSTPLSEAKKPA 753

Query: 63   SRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKP 122
            +   +    E+S +     +D ++AG     G   +  K G   K  +++  AV   +  
Sbjct: 754  ALKPKVPKKEESVK-----KDSVAAGKPKEKGKIKVIKKEG---KAAEAVAAAVGTGATT 805

Query: 123  DKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTI--- 179
                  +G+ A        +G  +E E E +  + PE    ++  + EEL   EV +   
Sbjct: 806  AAVMAAAGIAA--------IGPAKELEAERSLMSSPE---DLTKDF-EELKAEEVDVTKD 853

Query: 180  -----------------PPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSP 222
                              P    ++ K+  +T  PA+S     PD+ I     +  C   
Sbjct: 854  IKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAES-----PDEGITTTEGEGECEQT 908

Query: 223  TAAGKKTEKE--ESTEVLKAQSAGTVRSA--APPQEKKRKVEKDTMSDQALEALSASLGT 278
                +  EK+  +  E  + + AG   S+     +EK    E +   +   E +  S   
Sbjct: 909  PEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVS--A 966

Query: 279  RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 338
             +  P  D  S K   +A  +E++      DD    +E  +  A +K       + EE+ 
Sbjct: 967  SKHSPTEDEESAKAEADAYIREKRESVASGDDR---AEEDMDEAIEKGE---AEQSEEEA 1020

Query: 339  KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 398
                ++E   E   + ++ E ++      +K  E+   A          T     QS   
Sbjct: 1021 DEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEA-GGAEEQYGFLTTPTKQLGAQSPGR 1079

Query: 399  EPATL--KGTVPDDA-VEALADSLGKKEADPED 428
            EPA+     T+P  +  EA A     +E  PE+
Sbjct: 1080 EPASSIHDETLPGGSESEATASDEENREDQPEE 1112



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 99/476 (20%), Positives = 172/476 (36%), Gaps = 98/476 (20%)

Query: 255 KKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIP 314
           K+R   ++++   A    S S+     E   ++  +  V++    E K +   + D+ I 
Sbjct: 536 KQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIK 595

Query: 315 SEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKT--EE 372
           +E   KP+  +   P     +E+P P  ++E+ ++ + D      KEK  K   K   E+
Sbjct: 596 TE--TKPSVTEKEVP----SKEEPSP-VKAEVAEKQATDVKPKAAKEKTVKKETKVKPED 648

Query: 373 SKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPV 432
            K     P  E   +     I                           KKE  P+  +  
Sbjct: 649 KKEEKEKPKKEVAKKEDKTPI---------------------------KKEEKPKKEEVK 681

Query: 433 MDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPL-------------LPKESKE 479
            +  KE  KEE +E   E ++  PP    +EVK ++ K +             LPK++K+
Sbjct: 682 KEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKK 741

Query: 480 QLPPMSEDFLLDAL--------------SEDFSGPQNASSLKF--EDAKLAAAISEVVSQ 523
              P+SE     AL              S     P+    +K   ++ K A A++  V  
Sbjct: 742 SSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGT 801

Query: 524 TPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK--EKAKAEH 581
              +     A         K+L+     +S                ED  K  E+ KAE 
Sbjct: 802 GATTAAVMAAAGIAAIGPAKELEAERSLMSSP--------------EDLTKDFEELKAEE 847

Query: 582 RDKLGERDDTIPPEYRHLLDDNGQDKPVKPP-----TKKSEDSKKPADDQDPIDALSGDL 636
            D   +    I P+   L++D  + K  +P       K+ E +K PA+  D     +   
Sbjct: 848 VDVTKD----IKPQL-ELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGE 902

Query: 637 DSCPSTTETSQNTAK------DKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 686
             C  T E  +   K      +K +   +  +     G  ++ A+ TEE  +P++D
Sbjct: 903 GECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAE-TEEAEEPEED 957



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 147/721 (20%), Positives = 253/721 (35%), Gaps = 80/721 (11%)

Query: 18   QSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAE--QQPSEKST 75
            Q T++S     K +  +P   + P   PK A        H  +  S S E  Q+  E+S 
Sbjct: 1602 QETEMS---PSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSL 1658

Query: 76   EPKTKPQD----MISAGGESVA--GITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKS 129
                  Q      + AG   +   G T +   P D   +  SL+  +P   +P       
Sbjct: 1659 AMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDM--QDSSLSHKIPPMEEPSYTQ--- 1713

Query: 130  GMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGK-REVTIPPKYRELLA 188
              D  L +LI ++   E +   ++ +T  +++ P+    + ++   R++++   Y  L +
Sbjct: 1714 --DNDLSELI-SVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSL---YASLTS 1767

Query: 189  KK----EGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAG 244
            +K    EG    P     P+ P ++    S       PT +   +  +E T    + S+ 
Sbjct: 1768 EKVQSLEGEKLSPKSDISPLTPRESSPLYS-------PTFSDSTSAVKEKTATCHSSSSP 1820

Query: 245  TVRSA-APPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKL 303
             + +A A P   +  V  DTM      AL+  L T   E +   ++  +   A  K E+ 
Sbjct: 1821 PIDAASAEPYGFRASVLFDTMQHHL--ALNRDLSTPGLEKDSGGKTPGDFSYAYQKPEET 1878

Query: 304  EKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSES----ELIDELSEDFDRSEC 359
             +  ++++     Y     T   G     + E   K  S+S    E I + ++  +  + 
Sbjct: 1879 TRSPDEEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGKTTKTPEDGDY 1938

Query: 360  KEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSL 419
              +  + T +T E +      +SE    TS   +     E       + DD      DS 
Sbjct: 1939 SYEIIEKTTRTPE-EGGYSYDISEKT--TSPPEVSGYSYEKTERSRRLLDDISNGYDDSE 1995

Query: 420  --GKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD---YRLEEVKDKDGKP--- 471
              G    DP       +K+    + E        + T  PD   Y  E  +     P   
Sbjct: 1996 DGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYETAEKITRTPQAS 2055

Query: 472  --------LLPKESKEQLPPMSEDFLLDALSE-DFSGPQNASSLKFEDAKLAA--AISEV 520
                    L     K+      +D  L  +S  ++  P+   S  F +       A  E 
Sbjct: 2056 TYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEP 2115

Query: 521  VSQTPASTTQAGA--PPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 578
              ++    TQ+G   PP    Q  +  D+            Q D D   P E +      
Sbjct: 2116 TEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDV--PPETEECPSIT 2173

Query: 579  AEHRDKLGERDDTIPPE----YRHLLDDNG--QDKPVKP--PTKKSEDSKKPADDQDPID 630
            A+      +  +TIP +    Y+H+       QD+   P  P     D +  A +Q+   
Sbjct: 2174 ADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGK 2233

Query: 631  ALSGDLDSC-----PSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKD 685
            AL  DL        P T   S +  K    K+   + +PK  G  + S K +   S  K 
Sbjct: 2234 ALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKK 2293

Query: 686  D 686
            +
Sbjct: 2294 E 2294



 Score = 33.5 bits (75), Expect = 0.67
 Identities = 31/122 (25%), Positives = 51/122 (41%), Gaps = 20/122 (16%)

Query: 10   KTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQ 69
            KT+ +K    TK S   +K   + KP   +   +  K++SD  S  A  KK       ++
Sbjct: 2242 KTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKK-------KE 2294

Query: 70   PSEKSTEPKTKPQDMISAGGE-------------SVAGITAISGKPGDKKKEKKSLTPAV 116
              EK+ +P T P+   + G E             S +  TA +G    K  +  ++ P +
Sbjct: 2295 SVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVPPGL 2354

Query: 117  PV 118
            PV
Sbjct: 2355 PV 2356


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 124/602 (20%), Positives = 210/602 (34%), Gaps = 136/602 (22%)

Query: 10  KTEPEKKSQSTKLSVVHEKKSQEGKPKEHTE---------PKSLPKQASDTGSNDAHNKK 60
           K   +K S S       E++  +G P +            P     +AS++ S++  +  
Sbjct: 76  KKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDD 135

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPA-VPVE 119
                 ++QP +K  +P+ K         +S    +  S +    K +K  +TP  V  +
Sbjct: 136 DDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQ 195

Query: 120 SK-PDKPSGKS-----GMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELG 173
           +K P KP+  +     G  A+      +    +++EEE    T  +              
Sbjct: 196 TKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKK-------------- 241

Query: 174 KREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEE 233
               T+P K  +++AK      P   ++ P     + +  SSD             E+EE
Sbjct: 242 ----TVPKK--QVVAK-----APVKAATTPTRKSSSSEDSSSD-------------EEEE 277

Query: 234 STEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEV 293
             + +K    G   S  PP     K                SLGT+  +        K V
Sbjct: 278 QKKPMK-NKPGPYSSVPPPSAPPPK---------------KSLGTQPPK--------KAV 313

Query: 294 DEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 353
           ++ +  E   +   E D +  SE   KP T    K ++ +   KP P  ++      S D
Sbjct: 314 EKQQPVESSEDSSDESDSS--SEEEKKPPT----KAVVSKATTKPPPAKKAAESSSDSSD 367

Query: 354 FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 413
            D SE  E PSKP   T+ S +  PA  +++               PA      P   V 
Sbjct: 368 SDSSEDDEAPSKPAGTTKNS-SNKPAVTTKS---------------PAVKPAAAPKQPVG 411

Query: 414 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 473
                          G+ ++ +  + +  E+     E+E+T      +   K K      
Sbjct: 412 G--------------GQKLLTRKADSSSSEEESSSSEEEKT---KKMVATTKPKATAKAA 454

Query: 474 PKESKEQLPPMSEDFLLD---ALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQ 530
                +Q P  S D   D   + SE+     + S++K +  K+A          PAS  +
Sbjct: 455 LSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGG---AAPSKPASAKK 511

Query: 531 AGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDEN-------------KPMEDKVKEKA 577
             A   ++S SD   ++  +KL      R   P  N             K  E++ +EK 
Sbjct: 512 GKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKK 571

Query: 578 KA 579
           KA
Sbjct: 572 KA 573



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 84/379 (22%), Positives = 139/379 (36%), Gaps = 67/379 (17%)

Query: 356 RSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEAL 415
           +++ K   S   + +EE +     P  +A        +   PP  A  K +    + E+ 
Sbjct: 77  KAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGL---PPGKAAAKASESSSSEESS 133

Query: 416 ADSLGKKEADPEDGK--PVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 473
            D       D ED K  PV   VK +AK         K      D   E+   K+ KP +
Sbjct: 134 DDD------DEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKI 187

Query: 474 -----------PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVS 522
                      P +     P ++      A S   S   ++SS   E+ K AA   + V 
Sbjct: 188 TPVTVKAQTKAPPKPARAAPKIANG---KAASSSSSSSSSSSSDDSEEEKAAATPKKTVP 244

Query: 523 Q----TPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQ-----------PDPDEN- 566
           +      A    A  P R +S S+    D  ++    +  +            P P ++ 
Sbjct: 245 KKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSL 304

Query: 567 --KPMEDKVKEKAKAEHRDKLGERDDTIPPEYRH----LLDDNGQDKPVKPPTKKSEDSK 620
             +P +  V+++   E  +   +  D+   E +      +      KP  PP KK+ +S 
Sbjct: 305 GTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKP--PPAKKAAESS 362

Query: 621 KPADDQDPIDALSGDLDSCPS----TTETSQN----TAKDKCKKAASSSKAPKNGG---- 668
             + D D     S + D  PS    TT+ S N    T K    K A++ K P  GG    
Sbjct: 363 SDSSDSD-----SSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLL 417

Query: 669 -KAKDSAKTTEETSKPKDD 686
            +  DS+ + EE+S  +++
Sbjct: 418 TRKADSSSSEEESSSSEEE 436



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 72/385 (18%), Positives = 135/385 (35%), Gaps = 65/385 (16%)

Query: 5   ETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHN------ 58
           + K +K +P   S     S    KKS   +P +    K  P ++S+  S+++ +      
Sbjct: 278 QKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEK 337

Query: 59  ----KKAVSRSAEQQP-SEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLT 113
               K  VS++  + P ++K+ E  +   D  S+  +      A + K    K    + +
Sbjct: 338 KPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKS 397

Query: 114 PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELG 173
           PAV   + P +P G          L+        +EEE+++    +    +++T  +   
Sbjct: 398 PAVKPAAAPKQPVGGG------QKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATA 451

Query: 174 KREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEE 233
           K  +++P K                    P G  D+    SSD    S     +KT K  
Sbjct: 452 KAALSLPAK------------------QAPQGSRDS----SSDSDSSSSEEEEEKTSKS- 488

Query: 234 STEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEV 293
           + +    + AG    + P   KK K E    S                            
Sbjct: 489 AVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSD------------------------- 523

Query: 294 DEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 353
           D ++ +EEKL+  G      P        T ++GK      EE+ + +  + ++ +    
Sbjct: 524 DSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSL 583

Query: 354 FDRSECKEKPSKPTEKTEESKAAAP 378
             R + +      T + ++ K   P
Sbjct: 584 KKRKQNEAAKEAETPQAKKIKLQTP 608



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 71/341 (20%), Positives = 131/341 (38%), Gaps = 29/341 (8%)

Query: 3   PTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAV 62
           P   K++ T+P KK+             ++ +P E +E  S    +S         K  V
Sbjct: 298 PPPKKSLGTQPPKKA------------VEKQQPVESSEDSSDESDSSSEEEKKPPTKAVV 345

Query: 63  SR-SAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESK 121
           S+ + +  P++K+ E  +   D  S+  +      A + K    K    + +PAV   + 
Sbjct: 346 SKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAA 405

Query: 122 PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPP 181
           P +P G          L+        +EEE+++    +    +++T  +   K  +++P 
Sbjct: 406 PKQPVGGG------QKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPA 459

Query: 182 KYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSP--TAAGKKTEKEESTEVLK 239
           K        +G     +DS      ++  +  S       P   A G    K  S +  K
Sbjct: 460 K-----QAPQGSRDSSSDSDSSSSEEEE-EKTSKSAVKKKPQKVAGGAAPSKPASAKKGK 513

Query: 240 AQSAGTVRSAAPPQEKKRKVE-KDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKA 298
           A+S+ +  S    +E++ K++ K +   QA +A   S  T Q   +    S +E +E K 
Sbjct: 514 AESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQ-NGKAAKNSEEEEEEKKK 572

Query: 299 KEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPK 339
               + K G   +   +E   +  T +  K  L  P   PK
Sbjct: 573 AAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPK 613


>gi|151301171 RNA polymerase II transcription factor TAFII140 [Homo
           sapiens]
          Length = 929

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 110/502 (21%), Positives = 182/502 (36%), Gaps = 73/502 (14%)

Query: 3   PTETKA----VKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTG---SND 55
           P ETK+     KT+     Q TK     +  +  G P     PK++ K+    G   S  
Sbjct: 262 PLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIR--SPKTVSKEKKSPGRSKSPK 319

Query: 56  AHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI-----SGKPGDKKKEKK 110
           +     V+    Q P    T  +T    +     +    +  I     +GK   + + KK
Sbjct: 320 SPKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKK 379

Query: 111 SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETE--EENTTYTGPEVSDPMSSTY 168
           ++     +E+  D    ++  +   D    + G   E +        +GPE + P +ST 
Sbjct: 380 AVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTS 439

Query: 169 IEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKK 228
                K   T  P           ++G  + S      D +ID +      G+P+     
Sbjct: 440 ANNFTKSGSTPLP-----------LSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPN 488

Query: 229 TEKEESTEVL--------KAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQ 280
                S  V         K     T   ++   +KK K E  T   +  +        R+
Sbjct: 489 FPYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRD-----RE 543

Query: 281 AEPELDLRSIKEVDEAKAKEEKLEKCGE----------DDETIPSEYRLKPATDKDGKPL 330
            E + +    KE D+ K KE+  E   E          ++E  P ++++K   D D K  
Sbjct: 544 REKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVK 603

Query: 331 LPEP---EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAP---VSEA 384
           L +    +EK K + + +  ++  +D D+ E KEK     +K  E K  APAP   +   
Sbjct: 604 LKDGLVRKEKEKHKDKKKDREKGKKDKDKRE-KEKVK---DKGREDKMKAPAPPLVLPPK 659

Query: 385 VCRTSMCSIQSAPPEPATLKGTVP---------DDAVEALADSLGKKEA----DPEDGKP 431
                + S  +A   PA L   +P          + V+       KKE     + E  K 
Sbjct: 660 ELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKK 719

Query: 432 VMDKVKEKAKEEDREKLGEKEE 453
             ++ KEK + E REK  EK +
Sbjct: 720 EKEREKEKREREKREKEKEKHK 741



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 103/528 (19%), Positives = 180/528 (34%), Gaps = 100/528 (18%)

Query: 150 EENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDA 209
           +++T    P    PM +   +   +     P + +    K +  T  P   +K   P  A
Sbjct: 234 QDSTDLAPPSPEPPMLAPVAKS--QMPTAKPLETKSFTPKTKTKTSSPGQKTK--SPKTA 289

Query: 210 IDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKV-----EKDTM 264
                S    GSP  + K   KE+       +S G  RS +P   K  KV     +    
Sbjct: 290 ----QSPAMVGSPIRSPKTVSKEK-------KSPG--RSKSPKSPKSPKVTTHIPQTPVR 336

Query: 265 SDQALEALSASLGTRQAEPELDLRSIKEVDEAKA--KEEKLEKCGEDDETI--------- 313
            +      SA+L  + ++  + ++ I+   +A     E + +K    D+TI         
Sbjct: 337 PETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIA 396

Query: 314 -------PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKP 366
                  P  +     ++ +G  +   P+    P   +      + +F +S     P   
Sbjct: 397 RACAEREPDPFEFSSGSESEGD-IFTSPKRISGPECTTPKASTSANNFTKSGSTPLPLSG 455

Query: 367 TEKTEESKAAAPAPVSEAVCRTSM-------------CSIQSAPPEPATL------KGTV 407
              + ++     A + E V +  +              S   +PP P  L      K  +
Sbjct: 456 GTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKL 515

Query: 408 PDDAV------EALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEK---------- 451
           P          + L   + KKE    D +   DK K+K+KE+D+ K  EK          
Sbjct: 516 PSSVEVKKKLKKELKTKMKKKEKQ-RDREREKDKNKDKSKEKDKVKEKEKDKETGRETKY 574

Query: 452 --------EETIPPDYRLEEVKDKDGKPLLP----KESKEQLPPMSEDFLLDALSEDFSG 499
                   EE  P  ++++E +D D K  L     ++ KE+     +D       +D   
Sbjct: 575 PWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKRE 634

Query: 500 PQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSL--- 556
            +       ED   A A   V+   P         P   S+    L   L  L + L   
Sbjct: 635 KEKVKDKGREDKMKAPAPPLVL--PPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEE 692

Query: 557 ------GQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRH 598
                  +++ D  E K  ++K KEK + E   +  ER+     + +H
Sbjct: 693 KEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKH 740


>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
          Length = 2454

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 139/742 (18%), Positives = 263/742 (35%), Gaps = 133/742 (17%)

Query: 3    PTETKAVKTEPEKKSQST-----KLSVVHEKKSQEGK-------PKEHTEPKSLPKQASD 50
            PTET  V +  +++   T     KLSV   KK +          PK +  PKS   +  D
Sbjct: 629  PTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVD 688

Query: 51   TGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKK 110
              S D+    A+ +   +     S++        I    +++  +   +GK    K+++K
Sbjct: 689  QNS-DSDEMLAILKEVSRMSHSSSSDTDINE---IHTNHKTLYDLKTQAGKDDKGKRKRK 744

Query: 111  SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIE 170
            S T     ++K     GKS   + +           +T+ E++ Y   E+   + S  + 
Sbjct: 745  SSTSGSDFDTK----KGKSAKSSIISKK------KRQTQSESSNYDS-ELEKEIKS--MS 791

Query: 171  ELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTE 230
            ++G    T     ++ +   +       +     G D+           GS   A +K E
Sbjct: 792  KIGAARTT-----KKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQE 846

Query: 231  KEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSI 290
            +E  +      + GTV       E + ++ K   +  + + +    G  Q+   L++R +
Sbjct: 847  RETFSS-----AEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKV 901

Query: 291  KEV--------------------------------DEAKAKEEKLEKCGEDDETIPSEYR 318
             E                                 DE    ++K  K G +++  PS+++
Sbjct: 902  AETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFK 961

Query: 319  LKP-------ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE 371
             K         +  DG   LPE EE        + I   + D ++   K +     +K E
Sbjct: 962  KKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDE 1021

Query: 372  ESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGK- 430
             S  A                      E +T KG    D+ ++  D   K  A   + K 
Sbjct: 1022 LSDYA----------------------EKSTGKG----DSCDSSEDKKSKNGAYGREKKR 1055

Query: 431  -PVMDKVKEKAKE---EDREKLGEKEETI-PPDYRLEEVKDKDGKPLLPKESKEQLPPMS 485
              ++ K   K ++    D EK   KE+     D RL+ ++ ++ + L  K + +++   S
Sbjct: 1056 CKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGS 1115

Query: 486  EDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVV-SQTPASTTQAGAPPRDTSQSDKD 544
                 +  SED    +  +S K    K A  + E   +    ST +  A    +S SD +
Sbjct: 1116 SSSDAEESSEDNKKKKQRTSSK----KKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIE 1171

Query: 545  LDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGER--DDTIPPEYRHLLDD 602
             DD      +S+G+   D  + KP+ + +   +        G+     ++P       DD
Sbjct: 1172 DDD-----QNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDD 1226

Query: 603  NGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSK 662
            N  +  +       E     + D+D       +     +  +  +N   ++ K   +S  
Sbjct: 1227 NDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNS-- 1284

Query: 663  APKNGGKAKDSAKTTEETSKPK 684
                     +S   +EE+ KP+
Sbjct: 1285 ---------ESDSDSEESKKPR 1297



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 150/739 (20%), Positives = 273/739 (36%), Gaps = 115/739 (15%)

Query: 5    ETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSR 64
            ETKA K E     +   +S    K S++    EH   +++P +   T  +     K   R
Sbjct: 402  ETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMH-QNVPTEEQRTNKSTGGEHKKSDR 460

Query: 65   SAEQQPSEKSTE----------PKTKPQDMISAGGESVAGITAISGKPGD----KKKEKK 110
              E Q    +T           P + P+D I    E+   + +     GD     ++E +
Sbjct: 461  KEEPQYEPANTSEDLDMDIVSVPSSVPED-IFENLETAMEVQSSVDHQGDGSSGTEQEVE 519

Query: 111  SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSD-PMSSTYI 169
            S +  + + SK ++   KS   A +            T+E     T   +S+ P+     
Sbjct: 520  SSSVKLNISSKDNRGGIKSKTTAKV------------TKELYVKLTPVSLSNSPIKGADC 567

Query: 170  EEL-----GKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCG---S 221
            +E+     G +   + PK      +K G+    +D+   +  + ++    SD        
Sbjct: 568  QEVPQDKDGYKSCGLNPK-----LEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVK 622

Query: 222  PTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALE-----ALSASL 276
             T   + TE    T     +   TV+         RK +K   SD A++      L  S 
Sbjct: 623  TTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSK 682

Query: 277  GTRQAEPELD-------LRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKP 329
             +   +   D       L+ +  +  + + +  + +   + +T+   Y LK    KD K 
Sbjct: 683  QSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTL---YDLKTQAGKDDK- 738

Query: 330  LLPEPEEKPKPRSESELIDELSEDFDRSECKEKP----SKPTEKTEESKAAAPAPVSEAV 385
                   K K +S +        DFD  + K       SK   +T+   +   + + + +
Sbjct: 739  ------GKRKRKSSTS-----GSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEI 787

Query: 386  CRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVK----EKAK 441
               SM  I +A      +  T   D+ E   +   KK  D +  K +    +    +  +
Sbjct: 788  --KSMSKIGAARTTKKRIPNTKDFDSSE--DEKHSKKGMDNQGHKNLKTSQEGSSDDAER 843

Query: 442  EEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ 501
            +++RE     E T+  D  + E++D+     LPK  K+Q    ++   +D LS      Q
Sbjct: 844  KQERETFSSAEGTVDKDTTIMELRDR-----LPK--KQQASASTDG--VDKLS---GKEQ 891

Query: 502  NASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQP 561
            + +SL+          S+ +        Q G    D ++     D + +   D   Q + 
Sbjct: 892  SFTSLEVRKVAETKEKSKHLKTKTCKKVQDGL--SDIAEKFLKKDQSDETSEDDKKQSKK 949

Query: 562  DPDENKPMEDKVKEKAKAEHR--------DKLGERDDTIP-PEYRHLLDDNGQDKPVKPP 612
              +E K   D  K+  K E +        +KL ER++    P+    + +   D   K  
Sbjct: 950  GTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSK 1009

Query: 613  TKKSEDSKKPADDQDPIDALSGDLDSCPSTTE-TSQNTA----KDKCKKAASSSKAPKNG 667
              + + SKK  +  D  +  +G  DSC S+ +  S+N A    K +CK    SS+     
Sbjct: 1010 KIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSR----- 1064

Query: 668  GKAKDSAKTTEETSKPKDD 686
             K +D + +  E    K+D
Sbjct: 1065 -KRQDCSSSDTEKYSMKED 1082



 Score = 37.7 bits (86), Expect = 0.036
 Identities = 117/604 (19%), Positives = 212/604 (35%), Gaps = 93/604 (15%)

Query: 15   KKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPK---------QASDTGSNDAHNKKAVSRS 65
            KK QS + S   +K+S++G  +E  +P    K         ++S  G+     ++ +   
Sbjct: 932  KKDQSDETSEDDKKQSKKGT-EEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHF 990

Query: 66   AE------------QQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLT 113
             +            ++ S+K  +  +K +D +S   E   G     G   D  ++KKS  
Sbjct: 991  PKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTG----KGDSCDSSEDKKSKN 1046

Query: 114  PAVPVESKPDKPSGKSGMDAALDDLIDT----------------LGGPEETEEENTTY-- 155
             A   E K  K  GKS          DT                L   E  E  N +   
Sbjct: 1047 GAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKR 1106

Query: 156  TGPEVSDPMSSTYIEELG-----KREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAI 210
               E+    SS+  EE       K++ T   K   ++ +K+  +   +   K     D  
Sbjct: 1107 NTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQA---DIT 1163

Query: 211  DALSSDFTCGSPTAAGKKTEKEESTE------VLKAQSAGTVRSAAPPQEKKRKVEKDTM 264
             + SSD       + G+ +  E+  +      VL + +     S      K   V  D  
Sbjct: 1164 SSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDD 1223

Query: 265  SDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATD 324
             D        +      E + +L S ++       EE  ++ G+ +E  P +   K   +
Sbjct: 1224 DDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVN 1283

Query: 325  KDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE------------- 371
             +      + EE  KPR    L+       D    +EK +KP E  E             
Sbjct: 1284 SESDS---DSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSED 1340

Query: 372  -ESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGK 430
             E      + VSE V      S     P   + K    ++   +      ++    ++  
Sbjct: 1341 SEDSDFQESGVSEEVSE----SEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDS 1396

Query: 431  PVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLL 490
               +K   + +EE++E+  E+EE        EE +D++     P + ++++  + +D  L
Sbjct: 1397 SSENKSNSEEEEEEKEEEEEEEEE-----EEEEEEDENDDSKSPGKGRKKIRKILKDDKL 1451

Query: 491  -----DALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDL 545
                 +AL E+    +  +  + E  KL     EV+    AS T+     +     D++ 
Sbjct: 1452 RTETQNALKEEEERRKRIAEREREREKL----REVIEIEDASPTKCPITTKLVLDEDEET 1507

Query: 546  DDAL 549
             + L
Sbjct: 1508 KEPL 1511



 Score = 33.9 bits (76), Expect = 0.51
 Identities = 70/363 (19%), Positives = 130/363 (35%), Gaps = 52/363 (14%)

Query: 10   KTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQ 69
            K + ++ S   K  +V EKK    +     +   +   +S    +D  N      S EQ+
Sbjct: 1128 KKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQK 1187

Query: 70   --PSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSG 127
              P  ++    +      S+G E+++    ++    D   + ++   A  +  +  K + 
Sbjct: 1188 IKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRI-AKKMLLEEIKANL 1246

Query: 128  KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELL 187
             S  D + DD  +   G + T ++N    G E  +  +    E     E +  P+YR  L
Sbjct: 1247 SSDEDGSSDD--EPEEGKKRTGKQNEENPGDE--EAKNQVNSESDSDSEESKKPRYRHRL 1302

Query: 188  AKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVR 247
             + + +T    +S +                        KKT+ +E  EV          
Sbjct: 1303 LRHK-LTVSDGESGEE-----------------------KKTKPKEHKEV---------- 1328

Query: 248  SAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCG 307
                    +RKV  +   D   +    S    ++E E   R+        AK+ +LE+  
Sbjct: 1329 ----KGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRT------RSAKKAELEENQ 1378

Query: 308  EDDETIPSEYRLKPATDKDGKPLL-PEPEEKPKPRSESELIDELSEDFDRSECKEKPSKP 366
               +      R+K   D   +     E EE+ K   E E  +E  E+ D ++  + P K 
Sbjct: 1379 RSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKG 1438

Query: 367  TEK 369
             +K
Sbjct: 1439 RKK 1441


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.299    0.121    0.327 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,595,929
Number of Sequences: 37866
Number of extensions: 1772877
Number of successful extensions: 12034
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 107
Number of HSP's successfully gapped in prelim test: 909
Number of HSP's that attempted gapping in prelim test: 7963
Number of HSP's gapped (non-prelim): 3573
length of query: 686
length of database: 18,247,518
effective HSP length: 109
effective length of query: 577
effective length of database: 14,120,124
effective search space: 8147311548
effective search space used: 8147311548
T: 11
A: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.