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Search of human proteins with 27437045
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27437045 colony stimulating factor 3 receptor isoform d
precursor [Homo sapiens]
(783 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27437045 colony stimulating factor 3 receptor isoform d precu... 1654 0.0
gi|4503081 colony stimulating factor 3 receptor isoform a precur... 1583 0.0
gi|24496783 colony stimulating factor 3 receptor isoform c precu... 1568 0.0
gi|27437042 colony stimulating factor 3 receptor isoform b precu... 1316 0.0
gi|28610147 interleukin 6 signal transducer isoform 1 precursor ... 245 1e-64
gi|115430248 gp130-like monocyte receptor [Homo sapiens] 177 3e-44
gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens] 155 1e-37
gi|28610149 interleukin 6 signal transducer isoform 2 precursor ... 124 3e-28
gi|4504993 leukemia inhibitory factor receptor precursor [Homo s... 102 2e-21
gi|189083786 leukemia inhibitory factor receptor precursor [Homo... 102 2e-21
gi|4557040 oncostatin M receptor [Homo sapiens] 92 1e-18
gi|4759328 class I cytokine receptor [Homo sapiens] 91 3e-18
gi|4758062 cytokine receptor-like factor 1 [Homo sapiens] 82 1e-15
gi|51093381 leptin receptor isoform 3 [Homo sapiens] 80 1e-14
gi|51093379 leptin receptor isoform 2 [Homo sapiens] 80 1e-14
gi|40254464 leptin receptor isoform 1 [Homo sapiens] 80 1e-14
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [... 79 2e-14
gi|4506107 prolactin receptor [Homo sapiens] 74 5e-13
gi|83281200 protogenin [Homo sapiens] 61 5e-09
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens] 60 8e-09
gi|24430212 interleukin 23 receptor precursor [Homo sapiens] 59 2e-08
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 56 1e-07
gi|93141049 collagen, type XII, alpha 1 short isoform precursor ... 54 7e-07
gi|93141047 collagen, type XII, alpha 1 long isoform precursor [... 54 7e-07
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom... 52 2e-06
gi|119220552 sidekick 1 [Homo sapiens] 52 2e-06
gi|157311649 neogenin homolog 1 [Homo sapiens] 51 4e-06
gi|219842266 usherin isoform B [Homo sapiens] 51 5e-06
gi|75709184 contactin 3 [Homo sapiens] 51 5e-06
gi|22212918 ciliary neurotrophic factor receptor preproprotein [... 51 5e-06
>gi|27437045 colony stimulating factor 3 receptor isoform d
precursor [Homo sapiens]
Length = 783
Score = 1654 bits (4282), Expect = 0.0
Identities = 783/783 (100%), Positives = 783/783 (100%)
Query: 1 MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQ 60
MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQ
Sbjct: 1 MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQ 60
Query: 61 ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAG 120
ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAG
Sbjct: 61 ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAG 120
Query: 121 YPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPK 180
YPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPK
Sbjct: 121 YPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPK 180
Query: 181 DGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPE 240
DGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPE
Sbjct: 181 DGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPE 240
Query: 241 AAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPA 300
AAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPA
Sbjct: 241 AAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPA 300
Query: 301 TAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVP 360
TAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVP
Sbjct: 301 TAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVP 360
Query: 361 LEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT 420
LEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT
Sbjct: 361 LEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT 420
Query: 421 PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRME 480
PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRME
Sbjct: 421 PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRME 480
Query: 481 QNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGK 540
QNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGK
Sbjct: 481 QNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGK 540
Query: 541 TWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHL 600
TWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHL
Sbjct: 541 TWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHL 600
Query: 601 MAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCGTAWLCCSPNRKNPLWP 660
MAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCGTAWLCCSPNRKNPLWP
Sbjct: 601 MAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCGTAWLCCSPNRKNPLWP 660
Query: 661 SVPDPAHSSLGSWVPTIMEEDAFQLPGLGTPPITKLTVLEEDEKKPVPWESHNSSETCGL 720
SVPDPAHSSLGSWVPTIMEEDAFQLPGLGTPPITKLTVLEEDEKKPVPWESHNSSETCGL
Sbjct: 661 SVPDPAHSSLGSWVPTIMEEDAFQLPGLGTPPITKLTVLEEDEKKPVPWESHNSSETCGL 720
Query: 721 PTLVQTYVLQGDPRAVSTQPQSQSGTSDQAGPPRRSAYFKDQIMLHPAPPNGLLCLFPIT 780
PTLVQTYVLQGDPRAVSTQPQSQSGTSDQAGPPRRSAYFKDQIMLHPAPPNGLLCLFPIT
Sbjct: 721 PTLVQTYVLQGDPRAVSTQPQSQSGTSDQAGPPRRSAYFKDQIMLHPAPPNGLLCLFPIT 780
Query: 781 SVL 783
SVL
Sbjct: 781 SVL 783
>gi|4503081 colony stimulating factor 3 receptor isoform a precursor
[Homo sapiens]
Length = 836
Score = 1583 bits (4098), Expect = 0.0
Identities = 749/749 (100%), Positives = 749/749 (100%)
Query: 1 MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQ 60
MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQ
Sbjct: 1 MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQ 60
Query: 61 ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAG 120
ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAG
Sbjct: 61 ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAG 120
Query: 121 YPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPK 180
YPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPK
Sbjct: 121 YPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPK 180
Query: 181 DGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPE 240
DGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPE
Sbjct: 181 DGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPE 240
Query: 241 AAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPA 300
AAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPA
Sbjct: 241 AAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPA 300
Query: 301 TAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVP 360
TAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVP
Sbjct: 301 TAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVP 360
Query: 361 LEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT 420
LEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT
Sbjct: 361 LEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT 420
Query: 421 PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRME 480
PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRME
Sbjct: 421 PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRME 480
Query: 481 QNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGK 540
QNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGK
Sbjct: 481 QNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGK 540
Query: 541 TWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHL 600
TWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHL
Sbjct: 541 TWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHL 600
Query: 601 MAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCGTAWLCCSPNRKNPLWP 660
MAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCGTAWLCCSPNRKNPLWP
Sbjct: 601 MAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCGTAWLCCSPNRKNPLWP 660
Query: 661 SVPDPAHSSLGSWVPTIMEEDAFQLPGLGTPPITKLTVLEEDEKKPVPWESHNSSETCGL 720
SVPDPAHSSLGSWVPTIMEEDAFQLPGLGTPPITKLTVLEEDEKKPVPWESHNSSETCGL
Sbjct: 661 SVPDPAHSSLGSWVPTIMEEDAFQLPGLGTPPITKLTVLEEDEKKPVPWESHNSSETCGL 720
Query: 721 PTLVQTYVLQGDPRAVSTQPQSQSGTSDQ 749
PTLVQTYVLQGDPRAVSTQPQSQSGTSDQ
Sbjct: 721 PTLVQTYVLQGDPRAVSTQPQSQSGTSDQ 749
>gi|24496783 colony stimulating factor 3 receptor isoform c
precursor [Homo sapiens]
Length = 863
Score = 1568 bits (4060), Expect = 0.0
Identities = 749/776 (96%), Positives = 749/776 (96%), Gaps = 27/776 (3%)
Query: 1 MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQ 60
MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQ
Sbjct: 1 MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQ 60
Query: 61 ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAG 120
ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAG
Sbjct: 61 ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAG 120
Query: 121 YPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPK 180
YPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPK
Sbjct: 121 YPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPK 180
Query: 181 DGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPE 240
DGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPE
Sbjct: 181 DGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPE 240
Query: 241 AAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPA 300
AAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPA
Sbjct: 241 AAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPA 300
Query: 301 TAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVP 360
TAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVP
Sbjct: 301 TAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVP 360
Query: 361 LEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT 420
LEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT
Sbjct: 361 LEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT 420
Query: 421 PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRME 480
PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRME
Sbjct: 421 PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRME 480
Query: 481 QNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGK 540
QNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGK
Sbjct: 481 QNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGK 540
Query: 541 TWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHL 600
TWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHL
Sbjct: 541 TWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHL 600
Query: 601 MAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCGTAWLCCSPNRKNPLWP 660
MAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCGTAWLCCSPNRKNPLWP
Sbjct: 601 MAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCGTAWLCCSPNRKNPLWP 660
Query: 661 SVPDPAHSSLGSWVPTIMEE---------------------------DAFQLPGLGTPPI 693
SVPDPAHSSLGSWVPTIMEE DAFQLPGLGTPPI
Sbjct: 661 SVPDPAHSSLGSWVPTIMEELPGPRQGQWLGQTSEMSRALTPHPCVQDAFQLPGLGTPPI 720
Query: 694 TKLTVLEEDEKKPVPWESHNSSETCGLPTLVQTYVLQGDPRAVSTQPQSQSGTSDQ 749
TKLTVLEEDEKKPVPWESHNSSETCGLPTLVQTYVLQGDPRAVSTQPQSQSGTSDQ
Sbjct: 721 TKLTVLEEDEKKPVPWESHNSSETCGLPTLVQTYVLQGDPRAVSTQPQSQSGTSDQ 776
>gi|27437042 colony stimulating factor 3 receptor isoform b
precursor [Homo sapiens]
Length = 769
Score = 1316 bits (3407), Expect = 0.0
Identities = 622/623 (99%), Positives = 622/623 (99%)
Query: 1 MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQ 60
MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQ
Sbjct: 1 MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQ 60
Query: 61 ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAG 120
ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAG
Sbjct: 61 ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAG 120
Query: 121 YPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPK 180
YPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPK
Sbjct: 121 YPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPK 180
Query: 181 DGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPE 240
DGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPE
Sbjct: 181 DGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPE 240
Query: 241 AAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPA 300
AAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPA
Sbjct: 241 AAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPA 300
Query: 301 TAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVP 360
TAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVP
Sbjct: 301 TAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVP 360
Query: 361 LEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT 420
LEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT
Sbjct: 361 LEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT 420
Query: 421 PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRME 480
PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRME
Sbjct: 421 PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRME 480
Query: 481 QNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGK 540
QNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGK
Sbjct: 481 QNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGK 540
Query: 541 TWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHL 600
TWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHL
Sbjct: 541 TWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHL 600
Query: 601 MAASQAGATNSTVLTLMTLTPEG 623
MAASQAGATNSTVLTLMTLTP G
Sbjct: 601 MAASQAGATNSTVLTLMTLTPAG 623
>gi|28610147 interleukin 6 signal transducer isoform 1 precursor
[Homo sapiens]
Length = 918
Score = 245 bits (626), Expect = 1e-64
Identities = 208/731 (28%), Positives = 325/731 (44%), Gaps = 63/731 (8%)
Query: 10 TWA--ALIILLLPGS----LEECGHISVSAPIVHLGDPITASCIIKQNCS---HLDPEPQ 60
TW AL I L S L+ CG+IS +P+V L TA C++K+ C H++
Sbjct: 6 TWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN-Y 64
Query: 61 ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSC-CLNWGNSLQILDQVELRA 119
I+W+ P ++Q S +T + L+C L +G Q + + + +
Sbjct: 65 IVWKTNHFTIP--KEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS 122
Query: 120 GYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVP 179
G PP P NLSC++N + C+W+ G ETHL T+FTLKS + DC
Sbjct: 123 GLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKS-------EWATHKFADCKA 174
Query: 180 KDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSP 239
K C + + N+ +WV+AENALG S + DP+ VK PP ++ S
Sbjct: 175 KRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234
Query: 240 EAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ--YELCGL 297
E + L+L W I K ++++ + ++W+ + P + + + + L
Sbjct: 235 ELS----SILKLTWTNPSIKSVIILKYNIQYRT-KDASTWSQIPPEDTASTRSSFTVQDL 289
Query: 298 LPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP------RT 351
P T Y +IRC++ G+WSDWS T E P+ W++ +DP RT
Sbjct: 290 KPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYK---IDPSHTQGYRT 346
Query: 352 VQLFWKPVPLEEDSGRIQGYVVS---WRPSGQAGAILPLCNTTELSCTFHLPSEAQEVAL 408
VQL WK +P E +G+I Y V+ W+ Q + N T+L T +L ++ L
Sbjct: 347 VQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTV----NATKL--TVNLTNDRYLATL 400
Query: 409 VAYNSAGTSRPT----PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG 464
N G S P ++ P + L A +D + LWV W P + Y++EW
Sbjct: 401 TVRNLVGKSDAAVLTIPACDFQATHPVMD-LKAFPKD-NMLWVEWTTPRESVKKYILEWC 458
Query: 465 LGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQE 524
+ A W+ E +G L+ N+ + Y I VTP+Y D G + + AY ++
Sbjct: 459 VLSDKAPCITD-WQQE-DGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQ 516
Query: 525 MAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRG 584
PS P + K +GK A LEW P ++ + +YTIF+ + +++S
Sbjct: 517 APPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTE 576
Query: 585 FVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCG 644
+ L L +LY + + A + G + T T E+ I+ L LLT L G
Sbjct: 577 YTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLG 636
Query: 645 TAWLCCSPNR---KNPLWPSVPDPAHSSLGSWVPTIMEEDAF----QLPGLGTPPITKLT 697
L C R K +WP+VPDP+ S + W P F Q+ G +
Sbjct: 637 V--LFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVV 694
Query: 698 VLEEDEKKPVP 708
+E ++KKP P
Sbjct: 695 EIEANDKKPFP 705
>gi|115430248 gp130-like monocyte receptor [Homo sapiens]
Length = 764
Score = 177 bits (450), Expect = 3e-44
Identities = 160/571 (28%), Positives = 246/571 (43%), Gaps = 44/571 (7%)
Query: 123 PAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRG----NCQTQGDSILDCV 178
PA P N+SC+ +L C W PG ET T +T+K + G NC T +
Sbjct: 54 PAKPENISCVYYYR-KNLTCTWSPGKETSY-TQYTVKRTYAFGEKHDNCTTNSST----- 106
Query: 179 PKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPS 238
+ ++ C + + N I V+AEN G S ++ K EPP + + P
Sbjct: 107 -SENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPV 165
Query: 239 PEAAPPQAGCLQLCW-EPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ---YEL 294
+Q+ W +P + + K LR + SW V + Y L
Sbjct: 166 LGIKR----MIQIEWIKPELAPVSSDLKYTLRFRTVNS-TSWMEVNFAKNRKDKNQTYNL 220
Query: 295 CGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP----- 349
GL P T Y + +RC WSDWS T E AP L+ W R L P
Sbjct: 221 TGLQPFTEYVIALRCAVKESK-FWSDWSQEKMGMTEEEAPC-GLELW---RVLKPAEADG 275
Query: 350 -RTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVAL 408
R V+L WK + GY + + P + NTT HL E+ V++
Sbjct: 276 RRPVRLLWKKARGAPVLEKTLGYNIWYYPESNTN-LTETMNTTNQQLELHLGGESFWVSM 334
Query: 409 VAYNSAGTSRPT----PVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG 464
++YNS G S P + +S +A D L V W+ ++IEW
Sbjct: 335 ISYNSLGKSPVATLRIPAIQEKSFQCIEVMQACVAED--QLVVKWQSSALDVNTWMIEWF 392
Query: 465 LGPPSASNSNKTWRMEQNGRATGFLLKEN-IRPFQLYEIIVTPLYQDTMGPSQHVYAYSQ 523
P + T E +AT + ++++ ++PF Y I V P+ D +G + AY++
Sbjct: 393 ---PDVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAK 449
Query: 524 EMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSR 583
E PS PE +++IG + W P K + +YTIF+ + FS +N+S
Sbjct: 450 EGVPSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSIL 509
Query: 584 GFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLC 643
+ L L+ + Y + +MA++ AG TN T + TL+ E+ +I L G LL+ +
Sbjct: 510 QYGLESLKRKTSYIVQVMASTSAGGTNGTSINFKTLSFSVFEIILITSLIGGGLLILIIL 569
Query: 644 GTAWLCCSPNRKNPL-WPSVPDPAHSSLGSW 673
A+ PN+ L WP+VP+PA SS+ +W
Sbjct: 570 TVAYGLKKPNKLTHLCWPTVPNPAESSIATW 600
>gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens]
Length = 862
Score = 155 bits (392), Expect = 1e-37
Identities = 183/717 (25%), Positives = 292/717 (40%), Gaps = 73/717 (10%)
Query: 7 CSLTWAALII-LLLPGSLEEC--GHISVS-APIVHLGDPITASCIIK--QNCSHLDPEPQ 60
CSL + +I LL+ ++ C G ++V + ++ LG + +C +K Q C H +
Sbjct: 8 CSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLGSTVNITCSLKPRQGCFHYSRRNK 67
Query: 61 ILWRLGAELQPGGRQQRLSDG--TQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELR 118
++ L R+ G + LP C+N + +QI E+
Sbjct: 68 LI------LYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACIN-SDEIQICG-AEIF 119
Query: 119 AGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTL-----KSFKSRGNCQTQGDS 173
G P P NLSC+ ++ C WE G +THL T +TL K+ + C+
Sbjct: 120 VGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCD 179
Query: 174 ILD----CVPKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEP 229
LD P+ +S N V A N+LG+S S +D+V+ P
Sbjct: 180 YLDFGINLTPESPES-------------NFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLP 226
Query: 230 PMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEA 289
P D + L W GL + + LR++P W +V +
Sbjct: 227 PW----DIRIKFQKASVSRCTLYWR--DEGLVLLNR--LRYRPSNSRL-WNMVNVTKAKG 277
Query: 290 LQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLD- 348
+++L L P T Y QI G WSDWS SL +T E PT LD W+ +R +D
Sbjct: 278 -RHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDY 336
Query: 349 -PRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQ-EV 406
+ + LFWK + + E G+I Y V+ + G + T S T +P V
Sbjct: 337 SRQQISLFWKNLSVSEARGKILHYQVTLQEL-TGGKAMTQNITGHTSWTTVIPRTGNWAV 395
Query: 407 ALVAYNSAGTSRPTPV---VFSESRGPALTRLHAMARDPHSLWVGWEPPNPWP---QGYV 460
A+ A NS G+S PT + E+ A ++ A + ++ V W+PP P Q YV
Sbjct: 396 AVSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYV 455
Query: 461 IEW-GLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVY 519
+EW L P + W + L+ ENI+ + YEI V L D G S +
Sbjct: 456 VEWRELHPGGDTQVPLNW-LRSRPYNVSALISENIKSYICYEIRVYALSGDQGGCSS-IL 513
Query: 520 AYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFW----TNAQNQSFS 575
S+ AP P ++ K + W P + L HY I+W +N+Q Q
Sbjct: 514 GNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCE 573
Query: 576 AILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGL 635
S ++ L+P Y + + A + AG ++ L + + + + +
Sbjct: 574 IPYRVSQNSHPINSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWMAFVAPSICI 633
Query: 636 LLLLTCLCGTAW----LCCSPNRKNPLWPS--VPDPAHSSLGSWVPTIMEEDAFQLP 686
+++ + T + + P W S +PDPA+S+ P + E+ QLP
Sbjct: 634 AIIMVGIFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTCAKKYP--IAEEKTQLP 688
>gi|28610149 interleukin 6 signal transducer isoform 2 precursor
[Homo sapiens]
Length = 329
Score = 124 bits (311), Expect = 3e-28
Identities = 96/325 (29%), Positives = 152/325 (46%), Gaps = 28/325 (8%)
Query: 10 TWA--ALIILLLPGS----LEECGHISVSAPIVHLGDPITASCIIKQNCS---HLDPEPQ 60
TW AL I L S L+ CG+IS +P+V L TA C++K+ C H++
Sbjct: 6 TWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNAN-Y 64
Query: 61 ILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSC-CLNWGNSLQILDQVELRA 119
I+W+ P ++Q S +T + L+C L +G Q + + + +
Sbjct: 65 IVWKTNHFTIP--KEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIIS 122
Query: 120 GYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVP 179
G PP P NLSC++N + C+W+ G ETHL T+FTLKS + DC
Sbjct: 123 GLPPEKPKNLSCIVN-EGKKMRCEWDGGRETHLETNFTLKS-------EWATHKFADCKA 174
Query: 180 KDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSP 239
K C + + N+ +WV+AENALG S + DP+ VK PP ++ S
Sbjct: 175 KRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSE 234
Query: 240 EAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQ--YELCGL 297
E + L+L W I K ++++ + ++W+ + P + + + + L
Sbjct: 235 EL----SSILKLTWTNPSIKSVIILKYNIQYR-TKDASTWSQIPPEDTASTRSSFTVQDL 289
Query: 298 LPATAYTLQIRCIRWPLPGHWSDWS 322
P T Y +IRC++ G+WSDWS
Sbjct: 290 KPFTEYVFRIRCMKEDGKGYWSDWS 314
>gi|4504993 leukemia inhibitory factor receptor precursor [Homo
sapiens]
Length = 1097
Score = 102 bits (253), Expect = 2e-21
Identities = 133/582 (22%), Positives = 221/582 (37%), Gaps = 69/582 (11%)
Query: 119 AGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHL----PTSFTL-KSFKSRGNCQTQGDS 173
AGYPP P L+C + +IC W PG T L TS+TL +SF + + ++
Sbjct: 329 AGYPPDTPQQLNCETH-DLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEA 387
Query: 174 ILDCVPKDGQSHCCIPRKHLLLYQ---NMGIW---VQAENALGTSMSPQLCLDPMDVVKL 227
+ + LL+Q N I+ + A N LG S S L V
Sbjct: 388 PTN-------------ESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPH 434
Query: 228 EPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPL 287
P + D + A ++L W IN CE+ K V +
Sbjct: 435 TPTSFKVKDINSTA-------VKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGV 487
Query: 288 EALQY--ELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQR 345
E Y L L P T YT +IRC WS WS + TTE +P+ DTW R+
Sbjct: 488 ENSSYLVALDKLNPYTLYTFRIRCSTETF-WKWSKWSNKKQHLTTEASPSKGPDTW-REW 545
Query: 346 QLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQE 405
D + + ++WKP+P+ E +G+I Y VS + ++ + + + L
Sbjct: 546 SSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPD-PQHKAEIRLDKNDYI 604
Query: 406 VALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGL 465
+++VA NS G+S P+ + E L ++ + + + W YVI+W
Sbjct: 605 ISVVAKNSVGSSPPSKIASMEIPNDDL-KIEQVVGMGKGILLTWHYDPNMTCDYVIKW-- 661
Query: 466 GPPSASNSNKT------WRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVY 519
NS+++ WR + + + RP Y + + +
Sbjct: 662 -----CNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMI 716
Query: 520 AYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQS------ 573
Y +E+AP AP ++ ++W P E + L Y ++ + +
Sbjct: 717 GYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVL 776
Query: 574 --------FSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSE 625
I + S + + L+ + YH+ L A + G ++ +T E S
Sbjct: 777 ESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGV--GPEKSMYVVTKENSV 834
Query: 626 LHIILGLFGLLLLLTCLCGTAWLCCSPNR--KNPLWPSVPDP 665
II L + + + T+ LC K +P +P+P
Sbjct: 835 GLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNP 876
>gi|189083786 leukemia inhibitory factor receptor precursor [Homo
sapiens]
Length = 1097
Score = 102 bits (253), Expect = 2e-21
Identities = 133/582 (22%), Positives = 221/582 (37%), Gaps = 69/582 (11%)
Query: 119 AGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHL----PTSFTL-KSFKSRGNCQTQGDS 173
AGYPP P L+C + +IC W PG T L TS+TL +SF + + ++
Sbjct: 329 AGYPPDTPQQLNCETH-DLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEA 387
Query: 174 ILDCVPKDGQSHCCIPRKHLLLYQ---NMGIW---VQAENALGTSMSPQLCLDPMDVVKL 227
+ + LL+Q N I+ + A N LG S S L V
Sbjct: 388 PTN-------------ESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPH 434
Query: 228 EPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPL 287
P + D + A ++L W IN CE+ K V +
Sbjct: 435 TPTSFKVKDINSTA-------VKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGV 487
Query: 288 EALQY--ELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQR 345
E Y L L P T YT +IRC WS WS + TTE +P+ DTW R+
Sbjct: 488 ENSSYLVALDKLNPYTLYTFRIRCSTETF-WKWSKWSNKKQHLTTEASPSKGPDTW-REW 545
Query: 346 QLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQE 405
D + + ++WKP+P+ E +G+I Y VS + ++ + + + L
Sbjct: 546 SSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPD-PQHKAEIRLDKNDYI 604
Query: 406 VALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGL 465
+++VA NS G+S P+ + E L ++ + + + W YVI+W
Sbjct: 605 ISVVAKNSVGSSPPSKIASMEIPNDDL-KIEQVVGMGKGILLTWHYDPNMTCDYVIKW-- 661
Query: 466 GPPSASNSNKT------WRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVY 519
NS+++ WR + + + RP Y + + +
Sbjct: 662 -----CNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMI 716
Query: 520 AYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQS------ 573
Y +E+AP AP ++ ++W P E + L Y ++ + +
Sbjct: 717 GYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVL 776
Query: 574 --------FSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSE 625
I + S + + L+ + YH+ L A + G ++ +T E S
Sbjct: 777 ESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGV--GPEKSMYVVTKENSV 834
Query: 626 LHIILGLFGLLLLLTCLCGTAWLCCSPNR--KNPLWPSVPDP 665
II L + + + T+ LC K +P +P+P
Sbjct: 835 GLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNP 876
>gi|4557040 oncostatin M receptor [Homo sapiens]
Length = 979
Score = 92.4 bits (228), Expect = 1e-18
Identities = 101/412 (24%), Positives = 163/412 (39%), Gaps = 41/412 (9%)
Query: 291 QYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDP- 349
+Y L L PAT Y ++RC WS+WS T E AP+ D W R L+P
Sbjct: 388 EYFLSELEPATEYMARVRCADASHFWKWSEWSGQ-NFTTLEAAPSEAPDVW-RIVSLEPG 445
Query: 350 -RTVQLFWKPVPLEEDSGRIQGYVVSW----RPSGQAGAILPL-CNTTELSCTFHLPSEA 403
TV LFWKP+ +G+I Y V +PS +P N+T+L L +
Sbjct: 446 NHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPANSTKLI----LDRCS 501
Query: 404 QEVALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEW 463
++ ++A NS G S + +V S +A + W+P GYV++W
Sbjct: 502 YQICVIANNSVGASPASVIVISADPENKEVEEERIAGTEGGFSLSWKPQPGDVIGYVVDW 561
Query: 464 GLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPS-QHVYAYS 522
+ W+ + + + RP Y+ + L + + YS
Sbjct: 562 CDHTQDVLGDFQ-WKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIACLLEKKTGYS 620
Query: 523 QEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSF----SAIL 578
QE+APS P + + + L W E + Y ++ + Q A+L
Sbjct: 621 QELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFEKAVL 680
Query: 579 ------------NASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSE- 625
N + ++ L+P S Y + + AG S T +T E S
Sbjct: 681 SDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAGEGPSATFTKVTTPDEHSSM 740
Query: 626 -LHIILGLF--GLLLLLTCLCGTAWLCCSPNRKNPLWPSVPDPAHSSLGSWV 674
+HI+L + LL+++ C + W+ K +P +PDP SS+ S +
Sbjct: 741 LIHILLPMVFCVLLIMVMCYLKSQWI------KETCYPDIPDPYKSSILSLI 786
>gi|4759328 class I cytokine receptor [Homo sapiens]
Length = 636
Score = 91.3 bits (225), Expect = 3e-18
Identities = 151/597 (25%), Positives = 224/597 (37%), Gaps = 79/597 (13%)
Query: 140 LICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPKDGQSHCCIPRKHLLLYQNM 199
L C WEP + P+ L+S K R N +TQ ++ G+S IPR+ L + +
Sbjct: 50 LNCSWEPLGDLGAPSELHLQSQKYRSN-KTQTVAVAA-----GRSWVAIPREQLTMSDKL 103
Query: 200 GIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPG 259
+W G + P + ++ +K P L E P +A + W P
Sbjct: 104 LVW---GTKAGQPLWPPVFVNLETQMKPNAPRLGPDVDFSEDDPLEA---TVHWAPPTWP 157
Query: 260 LHINQKCELRHKPQRGEASWALVGP----LPLEALQYELCGLLPATAYTLQIRCIRWPLP 315
H C+ ++ + EA+W L+ P +PL + E+ L AT Y + RC
Sbjct: 158 SHKVLICQFHYRRCQ-EAAWTLLEPELKTIPLTPV--EIQDLELATGYKVYGRCRMEKEE 214
Query: 316 GHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQ---LFWK-PVPLEEDSGRIQGY 371
W +WSP L +T AP D W + L WK P P + S ++ +
Sbjct: 215 DLWGEWSPILSFQTPPSAPK---DVWVSGNLCGTPGGEEPLLLWKAPGPCVQVSYKVWFW 271
Query: 372 V-------------VSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSR 418
V S PSG A + N T +L +LV +SA S
Sbjct: 272 VGGRELSPEGITCCCSLIPSGAEWARVSAVNATSWEPLTNL-------SLVCLDSA--SA 322
Query: 419 PTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWR 478
P V S G L V W+P P +V++W N W
Sbjct: 323 PRSVAVSSIAGST------------ELLVTWQPGPGEPLEHVVDWARDGDPLEKLN--WV 368
Query: 479 MEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPEL-HLKH 537
G + LL N Y I VT + + + V+ + +E+AP P L L+
Sbjct: 369 RLPPGNLSA-LLPGNFTVGVPYRITVTAVSASGLASASSVWGFREELAPLVGPTLWRLQD 427
Query: 538 IGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLE--PASL 595
+ W P + LTHYT+ + + S ++ +++ L L P L
Sbjct: 428 APPGTPAIAWGEVPRHQLRGHLTHYTLCAQSGTSPSVCMNVSGNTQSVTLPDLPWGPCEL 487
Query: 596 YHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLC-GTAWLCCSPNR 654
+ A Q L L T L IL L+GL LL L T+ C
Sbjct: 488 WVTASTIAGQGPPGPILRLHLPDNTLRWKVLPGILFLWGLFLLGCGLSLATSGRCYHLRH 547
Query: 655 K---NPLWPSVPDPAHSSLGSWVPTIMEEDAFQLPGLGTPPITKLTVLEEDEKKPVP 708
K +W VPDPA+SS G + Q+P P+ L +LE +E +P P
Sbjct: 548 KVLPRWVWEKVPDPANSSSG-------QPHMEQVP--EAQPLGDLPILEVEEMEPPP 595
>gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]
Length = 422
Score = 82.4 bits (202), Expect = 1e-15
Identities = 94/323 (29%), Positives = 138/323 (42%), Gaps = 47/323 (14%)
Query: 21 GSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQ----ILWRLGAELQPGGRQQ 76
GS IS P + +G + A+C + H DP + W L P +
Sbjct: 35 GSGAHTAVISPQDPTLLIGSSLLATCSV-----HGDPPGATAEGLYWTLNGRRLPPELSR 89
Query: 77 RLSDGTQESIITLPHLNHTQAF----LSCCLNWGNSLQILDQVELRAGYPPAIPHNLSCL 132
L+ T + L +LN ++ L C G+ IL L G PP P N+SC
Sbjct: 90 VLNASTLA--LALANLNGSRQRSGDNLVCHARDGS---ILAGSCLYVGLPPEKPVNISC- 143
Query: 133 MNLTTSSLICQWEPGP--ETHLPTSFTLKSFKSRGNCQTQGDSILDCVPKDGQSHCCIPR 190
+ L C+W PG ET L T+++LK +K R Q D+ + G C IP
Sbjct: 144 WSKNMKDLTCRWTPGAHGETFLHTNYSLK-YKLRWYGQ---DNTCEEYHTVGPHSCHIP- 198
Query: 191 KHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQ 250
K L L+ IWV+A N LG++ S L LD +DVV T DP P+ + G L+
Sbjct: 199 KDLALFTPYEIWVEATNRLGSARSDVLTLDILDVV--------TTDPPPDVHVSRVGGLE 250
Query: 251 ----LCW--EPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYT 304
+ W P K ++R++ + W +V + + L GL P T Y
Sbjct: 251 DQLSVRWVSPPALKDFLFQAKYQIRYRVE-DSVDWKVVDDVSNQT-SCRLAGLKPGTVYF 308
Query: 305 LQIRCIRWPL-----PGHWSDWS 322
+Q+RC + + G WS+WS
Sbjct: 309 VQVRCNPFGIYGSKKAGIWSEWS 331
>gi|51093381 leptin receptor isoform 3 [Homo sapiens]
Length = 958
Score = 79.7 bits (195), Expect = 1e-14
Identities = 111/531 (20%), Positives = 206/531 (38%), Gaps = 59/531 (11%)
Query: 35 IVHLGDPITASCIIKQNCSHLDPEPQILWRLG-AELQPGGRQQRLSDGTQESIITLPHLN 93
+ +G ++ CI K+ + + P +I+W + AE P + +SD + +T +LN
Sbjct: 341 LTSVGSNVSFHCIYKKE-NKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSK--VTFFNLN 397
Query: 94 HTQ--------AFLSC----CLNWGNSLQILDQVELRAGYPPAIPHNLSCLMNLTTSSLI 141
T+ A C C + L ++D + N+SC + + +
Sbjct: 398 ETKPRGKFTYDAVYCCNEHECHHRYAELYVID-----------VNINISCETDGYLTKMT 446
Query: 142 CQWEPGPETHLPTS-FTLKSFKSRGNCQTQGD-----SILDC-VPKDGQSHCCIPRKHLL 194
C+W L S L+ +S C DC + DG C + +
Sbjct: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIF--QPIF 504
Query: 195 LYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWE 254
L +W++ ++LG+ SP C+ P VVK PP G L++ WE
Sbjct: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP-----SSVKAEITINIGLLKISWE 559
Query: 255 -PWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWP 313
P P N + ++R+ E W + ++ L Y +Q+RC R
Sbjct: 560 KPVFP--ENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLD 617
Query: 314 LPGHWSDWSPSLELRTTERAPTVRLDTWWR----QRQLDPRTVQLFWKPVPLEEDSGRIQ 369
G+WS+WS + +R +WR + V L WKP+ + +Q
Sbjct: 618 GLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQ 677
Query: 370 GYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT-PVVFS--E 426
YV++ S + N T+ TF +A V ++A NS G S + FS
Sbjct: 678 RYVINHHTSCNGTWSEDVGNHTKF--TFLWTEQAHTVTVLAINSIGASVANFNLTFSWPM 735
Query: 427 SRGPALTRLHAMARDPHSLWVGW--EPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGR 484
S+ + L A + + V W P + ++IEW + + + + +
Sbjct: 736 SKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEW----KNLNEDGEIKWLRISSS 791
Query: 485 ATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHL 535
+ + ++ P + Y+ + P++ + +G + + +++Q+ H + L
Sbjct: 792 VKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGL 842
Score = 38.9 bits (89), Expect = 0.019
Identities = 30/111 (27%), Positives = 55/111 (49%), Gaps = 13/111 (11%)
Query: 214 SPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQ 273
SP + + P+++VK +PP+ M+ + + G L++ W P L L+++ +
Sbjct: 224 SPLMSVQPINMVKPDPPLGLHMEITDD------GNLKISWS--SPPL---VPFPLQYQVK 272
Query: 274 RGEASWALVGPLP--LEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWS 322
E S ++ + A + +LP ++Y +Q+R R PG WSDWS
Sbjct: 273 YSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323
>gi|51093379 leptin receptor isoform 2 [Homo sapiens]
Length = 896
Score = 79.7 bits (195), Expect = 1e-14
Identities = 111/531 (20%), Positives = 206/531 (38%), Gaps = 59/531 (11%)
Query: 35 IVHLGDPITASCIIKQNCSHLDPEPQILWRLG-AELQPGGRQQRLSDGTQESIITLPHLN 93
+ +G ++ CI K+ + + P +I+W + AE P + +SD + +T +LN
Sbjct: 341 LTSVGSNVSFHCIYKKE-NKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSK--VTFFNLN 397
Query: 94 HTQ--------AFLSC----CLNWGNSLQILDQVELRAGYPPAIPHNLSCLMNLTTSSLI 141
T+ A C C + L ++D + N+SC + + +
Sbjct: 398 ETKPRGKFTYDAVYCCNEHECHHRYAELYVID-----------VNINISCETDGYLTKMT 446
Query: 142 CQWEPGPETHLPTS-FTLKSFKSRGNCQTQGD-----SILDC-VPKDGQSHCCIPRKHLL 194
C+W L S L+ +S C DC + DG C + +
Sbjct: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIF--QPIF 504
Query: 195 LYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWE 254
L +W++ ++LG+ SP C+ P VVK PP G L++ WE
Sbjct: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP-----SSVKAEITINIGLLKISWE 559
Query: 255 -PWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWP 313
P P N + ++R+ E W + ++ L Y +Q+RC R
Sbjct: 560 KPVFP--ENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLD 617
Query: 314 LPGHWSDWSPSLELRTTERAPTVRLDTWWR----QRQLDPRTVQLFWKPVPLEEDSGRIQ 369
G+WS+WS + +R +WR + V L WKP+ + +Q
Sbjct: 618 GLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQ 677
Query: 370 GYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT-PVVFS--E 426
YV++ S + N T+ TF +A V ++A NS G S + FS
Sbjct: 678 RYVINHHTSCNGTWSEDVGNHTKF--TFLWTEQAHTVTVLAINSIGASVANFNLTFSWPM 735
Query: 427 SRGPALTRLHAMARDPHSLWVGW--EPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGR 484
S+ + L A + + V W P + ++IEW + + + + +
Sbjct: 736 SKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEW----KNLNEDGEIKWLRISSS 791
Query: 485 ATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHL 535
+ + ++ P + Y+ + P++ + +G + + +++Q+ H + L
Sbjct: 792 VKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGL 842
Score = 38.9 bits (89), Expect = 0.019
Identities = 30/111 (27%), Positives = 55/111 (49%), Gaps = 13/111 (11%)
Query: 214 SPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQ 273
SP + + P+++VK +PP+ M+ + + G L++ W P L L+++ +
Sbjct: 224 SPLMSVQPINMVKPDPPLGLHMEITDD------GNLKISWS--SPPL---VPFPLQYQVK 272
Query: 274 RGEASWALVGPLP--LEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWS 322
E S ++ + A + +LP ++Y +Q+R R PG WSDWS
Sbjct: 273 YSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323
>gi|40254464 leptin receptor isoform 1 [Homo sapiens]
Length = 1165
Score = 79.7 bits (195), Expect = 1e-14
Identities = 111/531 (20%), Positives = 206/531 (38%), Gaps = 59/531 (11%)
Query: 35 IVHLGDPITASCIIKQNCSHLDPEPQILWRLG-AELQPGGRQQRLSDGTQESIITLPHLN 93
+ +G ++ CI K+ + + P +I+W + AE P + +SD + +T +LN
Sbjct: 341 LTSVGSNVSFHCIYKKE-NKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSK--VTFFNLN 397
Query: 94 HTQ--------AFLSC----CLNWGNSLQILDQVELRAGYPPAIPHNLSCLMNLTTSSLI 141
T+ A C C + L ++D + N+SC + + +
Sbjct: 398 ETKPRGKFTYDAVYCCNEHECHHRYAELYVID-----------VNINISCETDGYLTKMT 446
Query: 142 CQWEPGPETHLPTS-FTLKSFKSRGNCQTQGD-----SILDC-VPKDGQSHCCIPRKHLL 194
C+W L S L+ +S C DC + DG C + +
Sbjct: 447 CRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIF--QPIF 504
Query: 195 LYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWE 254
L +W++ ++LG+ SP C+ P VVK PP G L++ WE
Sbjct: 505 LLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP-----SSVKAEITINIGLLKISWE 559
Query: 255 -PWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWP 313
P P N + ++R+ E W + ++ L Y +Q+RC R
Sbjct: 560 KPVFP--ENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLD 617
Query: 314 LPGHWSDWSPSLELRTTERAPTVRLDTWWR----QRQLDPRTVQLFWKPVPLEEDSGRIQ 369
G+WS+WS + +R +WR + V L WKP+ + +Q
Sbjct: 618 GLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQ 677
Query: 370 GYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPT-PVVFS--E 426
YV++ S + N T+ TF +A V ++A NS G S + FS
Sbjct: 678 RYVINHHTSCNGTWSEDVGNHTKF--TFLWTEQAHTVTVLAINSIGASVANFNLTFSWPM 735
Query: 427 SRGPALTRLHAMARDPHSLWVGW--EPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGR 484
S+ + L A + + V W P + ++IEW + + + + +
Sbjct: 736 SKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEW----KNLNEDGEIKWLRISSS 791
Query: 485 ATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHL 535
+ + ++ P + Y+ + P++ + +G + + +++Q+ H + L
Sbjct: 792 VKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGL 842
Score = 38.9 bits (89), Expect = 0.019
Identities = 30/111 (27%), Positives = 55/111 (49%), Gaps = 13/111 (11%)
Query: 214 SPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQ 273
SP + + P+++VK +PP+ M+ + + G L++ W P L L+++ +
Sbjct: 224 SPLMSVQPINMVKPDPPLGLHMEITDD------GNLKISWS--SPPL---VPFPLQYQVK 272
Query: 274 RGEASWALVGPLP--LEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWS 322
E S ++ + A + +LP ++Y +Q+R R PG WSDWS
Sbjct: 273 YSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWS 323
>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [Homo
sapiens]
Length = 1250
Score = 78.6 bits (192), Expect = 2e-14
Identities = 153/681 (22%), Positives = 251/681 (36%), Gaps = 102/681 (14%)
Query: 56 DPEPQILW-RLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQ 114
+P P + W GA L+P GR ++ G +IT L + N
Sbjct: 361 EPRPALRWLHNGAPLRPNGRV-KVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAAS 419
Query: 115 --VELRAGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPT--SFTLKSFKSRGNCQTQ 170
V +R G P A P ++ L++S+++ WE PE H F+L K+RG +
Sbjct: 420 LAVVVREGLPSA-PTRVTATP-LSSSAVLVAWER-PEMHSEQIIGFSLHYQKARGMDNVE 476
Query: 171 GDSILDCVPKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPP 230
++ + Q P Y V A + LG S + P
Sbjct: 477 YQFAVNNDTTELQVRDLEPNTDYEFY------VVAYSQLGASRTST------------PA 518
Query: 231 MLRTMDPSPEAAP------PQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGP 284
++ T+D P AAP P +++ W P P L Q + + + G+
Sbjct: 519 LVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFSTE 578
Query: 285 LPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDW----SPSLELRTTERAPTVRLDT 340
+ Q L L P Y ++I G S W +PS+ ++ L
Sbjct: 579 VRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFAPAELKV 638
Query: 341 WWRQRQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSG-------------------QA 381
Q ++ + W+P P +I GY + WR G
Sbjct: 639 -----QAKMESLVVSWQPPP---HPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDV 690
Query: 382 GAILPLCNTTELSCTFHLPSEAQEVALVAYNS---------AGTSRPTPVV-FSESRGPA 431
G + + T +P EV LVA+N G + P RGP
Sbjct: 691 GPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPP 750
Query: 432 L--TRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGL--GPPSASNSNKTWRMEQNGRATG 487
L +HA + S+W+ W+ P+ + ++ + + P N++ +G
Sbjct: 751 LPPAHVHAESNSSTSIWLRWKKPD-FTTVKIVNYTVRFSPWGLRNASLVTYYTSSGED-- 807
Query: 488 FLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQ-EMAPSHAP-ELHLKHIGKTWAQL 545
+L ++PF YE V D GP V S PS P +L L + + +L
Sbjct: 808 -ILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPLTPSTVRL 866
Query: 546 EWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFV----LHGLEPASLYHIHLM 601
W PP + Y I +++ Q +++G + +HGLE + Y +
Sbjct: 867 HWC--PPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFFKMG 924
Query: 602 AASQAG----ATNSTVLTLMTLTPEGSELHIILGL-----FGLLLLLTCLCGTAWLCCSP 652
A ++ G + V+TL + ++H + G+ GLL LL C+C A L SP
Sbjct: 925 ARTEVGPGPFSRLQDVITLQEKLSDSLDMHSVTGIIVGVCLGLLCLLACMC--AGLRRSP 982
Query: 653 NRKN-PLWPSVPDPAHSSLGS 672
+R++ P S P + +L S
Sbjct: 983 HRESLPGLSSTATPGNPALYS 1003
>gi|4506107 prolactin receptor [Homo sapiens]
Length = 622
Score = 73.9 bits (180), Expect = 5e-13
Identities = 58/227 (25%), Positives = 101/227 (44%), Gaps = 30/227 (13%)
Query: 109 LQILDQVELRAGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQ 168
L L+ L PP P C + + C W PG + LPT+++L +
Sbjct: 14 LLFLNTCLLNGQLPPGKPEIFKC-RSPNKETFTCWWRPGTDGGLPTNYSLTYHR------ 66
Query: 169 TQGDSILDCVPK---DGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVV 225
+G++++ P G + C +++ +++ + V A N +G+S S +L +D +V
Sbjct: 67 -EGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIV 125
Query: 226 KLEPPM-LRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKC-------ELRHKPQRGEA 277
+ +PP+ L PE P W W P I+ K E+R KP++ A
Sbjct: 126 QPDPPLELAVEVKQPEDRKP------YLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKA-A 178
Query: 278 SWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPS 324
W + + ++++ L P Y +Q+RC P G+WS WSP+
Sbjct: 179 EWEI--HFAGQQTEFKILSLHPGQKYLVQVRC--KPDHGYWSAWSPA 221
>gi|83281200 protogenin [Homo sapiens]
Length = 1150
Score = 60.8 bits (146), Expect = 5e-09
Identities = 59/245 (24%), Positives = 102/245 (41%), Gaps = 19/245 (7%)
Query: 399 LPSEAQEVALVAYNSAGT----SRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNP 454
+P + +A NS G+ +R T VV SE R A +HA ++ + WE P
Sbjct: 386 IPEDDAIYQCMAENSQGSILSRARLT-VVMSEDRPSAPYNVHAETMSSSAILLAWERPL- 443
Query: 455 WPQGYVIEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRP---FQLYEIIVTPLYQDT 511
+ VI + + A N G T + +++ P + Y + P+
Sbjct: 444 YNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQ 503
Query: 512 MGPSQHVYAYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQN 571
M S HV + E P PE+ L T + W+P P + + + Y + + +
Sbjct: 504 M--SDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTE 561
Query: 572 QSFSAI-LNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLT-------LMTLTPEG 623
S + L ++ ++L GL+P S+Y + + AA++ G S+V T P+
Sbjct: 562 NSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKS 621
Query: 624 SELHI 628
ELH+
Sbjct: 622 PELHL 626
Score = 48.5 bits (114), Expect = 2e-05
Identities = 48/212 (22%), Positives = 90/212 (42%), Gaps = 13/212 (6%)
Query: 400 PSEAQEVALVAYNSAGTSRPTPVVFSESRGPALTR---LHAMARDPHSLWVGWEP-PNPW 455
P+ +VAY G S+ + V + R + +R P + + W P P +
Sbjct: 485 PASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLPIPAKY 544
Query: 456 PQGYVIEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPS 515
+G V+ + L S N +E G +LL E ++P +Y + +T + +G S
Sbjct: 545 RRGQVVLYRLSF-RLSTENSIQVLELPGTTHEYLL-EGLKPDSVYLVRITAATRVGLGES 602
Query: 516 QHVYAYSQEMAPS----HAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTN-AQ 570
++ A S +PELHL+ + T + W + + + + Y +++ Q
Sbjct: 603 SVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDT--AAIQGYKLYYKEEGQ 660
Query: 571 NQSFSAILNASSRGFVLHGLEPASLYHIHLMA 602
++ L+ + L GL+P YH+ L+A
Sbjct: 661 QENGPIFLDTKDLLYTLSGLDPRRKYHVRLLA 692
Score = 45.8 bits (107), Expect = 2e-04
Identities = 111/531 (20%), Positives = 204/531 (38%), Gaps = 56/531 (10%)
Query: 123 PAIPHNLSCLMNLTTSSLICQWE-PGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPKD 181
P+ P+N+ +++S+++ WE P + ++++ K+ G + ++ +
Sbjct: 419 PSAPYNVHA-ETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIG----N 473
Query: 182 GQSHCCIPRKHLLLYQNMGIWVQAENALGTS-MSPQLCLDPMDVVKLEPPMLRTMDPSPE 240
+H I L N ++ A +G S MS + + ++ V L PP + SP
Sbjct: 474 DTTHYIID--DLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPT 531
Query: 241 AAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPA 300
+ + W P Q R + + V LP +Y L GL P
Sbjct: 532 D-------ILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPD 584
Query: 301 TAYTLQIRCIRWPLPGHWSDWSPSLELRTTE----RAPTVRLDTWWRQRQLDPRTVQLFW 356
+ Y ++I G S W+ + T ++P + L+ L+ T+ + W
Sbjct: 585 SVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEP------LNCTTISVRW 638
Query: 357 KPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFH--LPSEAQEVALVAYNS- 413
+ ED+ IQGY + ++ GQ +T +L T P V L+AYN+
Sbjct: 639 QQDV--EDTAAIQGYKLYYKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNI 696
Query: 414 -----AGTSRPTPVVFS-----ESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEW 463
A + TP S P L+A A S+++ W P + +I +
Sbjct: 697 DDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRP-AFTAAQIINY 755
Query: 464 GL--GPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGP-SQHVYA 520
+ P N++ ++ + +L + + P YE V P S VY
Sbjct: 756 TIRCNPVGLQNASLVLYLQ---TSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYH 812
Query: 521 YSQEMAPSHAP-ELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILN 579
+ AP+ P + + I A + W +PP+ ++ +T YTI + + +
Sbjct: 813 STLPEAPAGPPVGVKVTLIEDDTALVSW--KPPDGPETVVTRYTILYASRKAWIAGEWQV 870
Query: 580 ASSRGFV----LHGLEPASLYHIHLMAASQAG-ATNSTVLTLMTLTPEGSE 625
G + L L ++Y + + A+++ G S + L L E SE
Sbjct: 871 LHREGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVELAVLPKETSE 921
>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
Length = 2944
Score = 60.1 bits (144), Expect = 8e-09
Identities = 82/345 (23%), Positives = 135/345 (39%), Gaps = 39/345 (11%)
Query: 285 LPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQ 344
LP + +Y+L GL P T Y L + + L GH +P+ + T P V T +
Sbjct: 462 LPSDVTRYQLDGLQPGTEYRLTLYTL---LEGH-EVATPATVVPTGPELP-VSPVTDLQA 516
Query: 345 RQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSG-QAGAILPLCNTTELSCTFHLPSEA 403
+L + V++ W PVP G Q ++ G + +LP T F L
Sbjct: 517 TELPGQRVRVSWSPVP-----GATQYRIIVRSTQGVERTLVLPGSQT-----AFDLDDVQ 566
Query: 404 QEVALVAYNSA--GTSRPTPVVFSESRGP----ALTRLHAMARDPHSLWVGWEPPNPWPQ 457
++ SA G + V + R P A+ L + D + V W P P
Sbjct: 567 AGLSYTVRVSARVGPREGSASVLTVRREPETPLAVPGLRVVVSDATRVRVAWGPV-PGAS 625
Query: 458 GYVIEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQH 517
G+ I W G S S++T + + AT ++P Y++ V+ L GP+
Sbjct: 626 GFRISWSTG--SGPESSQT--LPPDSTATDI---TGLQPGTTYQVAVSVLRGREEGPAAV 678
Query: 518 VYAYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAI 577
+ A + + P +H+ + + W P G Y + W +A S +
Sbjct: 679 IVARTDPLGPVRT--VHVTQASSSSVTITWTRVPGATG------YRVSWHSAHGPEKSQL 730
Query: 578 LNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPE 622
++ + L GLEP + Y +H + A AG ++ PE
Sbjct: 731 VSGEATVAELDGLEPDTEYTVH-VRAHVAGVDGPPASVVVRTAPE 774
Score = 56.6 bits (135), Expect = 9e-08
Identities = 76/348 (21%), Positives = 118/348 (33%), Gaps = 46/348 (13%)
Query: 285 LPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQ 344
LP ++ ++ GL P T Y + + +R G + + RT P +
Sbjct: 643 LPPDSTATDITGLQPGTTYQVAVSVLR----GREEGPAAVIVARTDPLGPVRTVHV---- 694
Query: 345 RQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPS-GQAGAILPLCNTTELSCTFHLPSEA 403
Q +V + W VP GY VSW + G + L T P
Sbjct: 695 TQASSSSVTITWTRVP------GATGYRVSWHSAHGPEKSQLVSGEATVAELDGLEPDTE 748
Query: 404 QEVALVAYNSAGTSRPTPVVFSESRGPA--LTRLHAMARDPHSLWVGWEPPNPWPQGYVI 461
V + A+ + P VV + P ++RL + L + W
Sbjct: 749 YTVHVRAHVAGVDGPPASVVVRTAPEPVGRVSRLQILNASSDVLRITW------------ 796
Query: 462 EWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQL--------YEIIVTPLYQDTMG 513
+G A+ W + G +L N ++ Y + VT L D G
Sbjct: 797 ---VGVTGATAYRLAWGRSEGGPMRHQILPGNTDSAEIRGLEGGVSYSVRVTALVGDREG 853
Query: 514 PSQHVYAYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQS 573
+ + AP LH+ G+ +L W P P G + + W Q
Sbjct: 854 TPVSIVVTTPPEAPPALGTLHVVQRGEHSLRLRWEPVPRAQG------FLLHWQPEGGQE 907
Query: 574 FSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTP 621
S +L + L GLEPA+ Y + L AG S +T T +P
Sbjct: 908 QSRVLGPELSSYHLDGLEPATQYRVRLSVLGPAGEGPSAEVTARTESP 955
Score = 49.3 bits (116), Expect = 1e-05
Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 39/278 (14%)
Query: 365 SGRIQGYVVSWRPSGQAGAILPL--------CNTTELSCTFHLPSEAQEVALVAY--NSA 414
SG + GY V + P G LP T + P +V ++A NS
Sbjct: 256 SGPVTGYKVQYTPLTGLGQPLPSERQEVNVPAGETSVRLRGLRPLTEYQVTVIALYANSI 315
Query: 415 GTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGL--GPPSASN 472
G + + GP LT + A HSL V W P GY + W + G P+
Sbjct: 316 GEAVSGTARTTALEGPELTIQNTTA---HSLLVAWRSV-PGATGYRVTWRVLSGGPT--- 368
Query: 473 SNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPE 532
+ ++ G G +L ++ P YE+ V+ L+ ++GP+ + A + S
Sbjct: 369 -----QQQELGPGQGSVLLRDLEPGTDYEVTVSTLFGRSVGPATSLMARTD---ASVEQT 420
Query: 533 LHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFW--TNAQNQSFSAILNASSRGFVLHGL 590
L +G T L W P G Y + W +L + + L GL
Sbjct: 421 LRPVILGPTSILLSWNLVPEARG------YRLEWRRETGLEPPQKVVLPSDVTRYQLDGL 474
Query: 591 EPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHI 628
+P + Y + L + V T T+ P G EL +
Sbjct: 475 QPGTEYRLTLYTLLE----GHEVATPATVVPTGPELPV 508
Score = 43.1 bits (100), Expect = 0.001
Identities = 44/159 (27%), Positives = 65/159 (40%), Gaps = 30/159 (18%)
Query: 238 SPEAAPPQAGCL----------QLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPL 287
+P APP G L +L WEP Q L +P+ G+ ++GP
Sbjct: 862 TPPEAPPALGTLHVVQRGEHSLRLRWEPVPRA----QGFLLHWQPEGGQEQSRVLGP--- 914
Query: 288 EALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQL 347
E Y L GL PAT Y +++ + G ++ + E + R P++ L R
Sbjct: 915 ELSSYHLDGLEPATQYRVRLSVLGPAGEGPSAEVTARTE---SPRVPSIEL----RVVDT 967
Query: 348 DPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILP 386
+V L W PV R Y++SWRP G +P
Sbjct: 968 SIDSVTLAWTPV------SRASSYILSWRPLRGPGQEVP 1000
>gi|24430212 interleukin 23 receptor precursor [Homo sapiens]
Length = 629
Score = 58.9 bits (141), Expect = 2e-08
Identities = 55/233 (23%), Positives = 94/233 (40%), Gaps = 25/233 (10%)
Query: 116 ELRAGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFT--LKSFKSRGNCQTQGDS 173
++ +GYPP IP ++C++ + ++ C W G T++ T + +KS ++ Q S
Sbjct: 118 DISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSS 177
Query: 174 ILDCVPKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLR 233
++ Q +K+L +WVQA NALG S QL + D+V ++
Sbjct: 178 YINISTDSLQG----GKKYL-------VWVQAANALGMEESKQLQIHLDDIVIPSAAVIS 226
Query: 234 TMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYE 293
+ P + W+ ++ CE+R+K + +Q
Sbjct: 227 RAETINATVPKTI----IYWDSQTTIEKVS--CEMRYKATTNQTWNVKEFDTNFTYVQQS 280
Query: 294 LCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTV-----RLDTW 341
L P Y Q+RC + +W WS +T E P V + DTW
Sbjct: 281 EFYLEPNIKYVFQVRC-QETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHDTW 332
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 56.2 bits (134), Expect = 1e-07
Identities = 80/297 (26%), Positives = 117/297 (39%), Gaps = 63/297 (21%)
Query: 225 VKLEPPMLRTMDPSPEAAPPQA-------GCLQLCWEPW-QPGLHINQKCELRHKPQRGE 276
V +PP T SP AP Q + L W+P Q G + P G
Sbjct: 544 VSPDPP---TEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGN 600
Query: 277 ASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWPLPGHW--SDWSPSLE-LRTTERA 333
+ + LE + + GL P T Y +R + G W S+ SP E +RT + +
Sbjct: 601 TWRTVADGVQLET--HTVSGLQPNTIYLFLVRAV-----GAWGLSEPSPVSEPVRTQDSS 653
Query: 334 PTVRLDTWWRQRQ--------------LDPRTVQLFWK---PVPLEEDSGRIQGYVVSWR 376
P+ ++ WR +Q L PRT+Q+ W PV L +QG+ VSWR
Sbjct: 654 PSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQL------VQGFRVSWR 707
Query: 377 ---PSGQAGAILPLCNTTELSCTFH---------LPSEAQEVALVAYNSAGTSRPTPVVF 424
P G + +L L + ++ S + +AQ + S +R P
Sbjct: 708 VAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPE-- 765
Query: 425 SESRGPALTRLHAMARDPHS-LWVGWEPPNPWPQGYVIE----WGLGPPSASNSNKT 476
GP A+ D +S + V WEPP P Q VI W LG S + N++
Sbjct: 766 EAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRS 822
>gi|93141049 collagen, type XII, alpha 1 short isoform precursor [Homo
sapiens]
Length = 1899
Score = 53.5 bits (127), Expect = 7e-07
Identities = 106/518 (20%), Positives = 187/518 (36%), Gaps = 75/518 (14%)
Query: 122 PPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQT------QGDSIL 175
P + P NL + N T++SL +W+P T + GN QT Q +L
Sbjct: 588 PKSGPRNLQ-VYNATSNSLTVKWDPASGRVQKYRITYQPSTGEGNEQTTTIGGRQNSVVL 646
Query: 176 DCVPKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTM 235
+ D + + + G M+ + P++ V+ LR
Sbjct: 647 QKLKPDTPYTITVSSLY-------------PDGEGGRMTGRGKTKPLNTVR----NLRVY 689
Query: 236 DPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELC 295
DPS L + W+ + ++ +L + P G + P+P L
Sbjct: 690 DPSTST-------LNVRWDHAEGN---PRQYKLFYAPAAGGPEELV--PIPGNTNYAILR 737
Query: 296 GLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLF 355
L P T+YT+ + + G + + +R R V T P ++ +
Sbjct: 738 NLQPDTSYTVTVVPVYTEGDGGRTSDTGRTLMRGLARNVQVYNPT--------PNSLDVR 789
Query: 356 WKPVPLEEDSGRIQGYVVSWRP---SGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYN 412
W P P G + Y V + P + + +I+ NT + +P V LVA
Sbjct: 790 WDPAP-----GPVLQYRVVYSPVDGTRPSESIVVPGNTRMVHLERLIPDTLYSVNLVALY 844
Query: 413 SAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG--LGPPSA 470
S G P+P L +SL V W+ + Q Y I + +G P
Sbjct: 845 SDGEGNPSPAQGRTLPRSGPRNLRVFGETTNSLSVAWDHADGPVQQYRIIYSPTVGDPID 904
Query: 471 SNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHA 530
+ GR +L+ ++P Y+I V +Y+D G H+ + +
Sbjct: 905 EYTTVP------GRRNNVILQP-LQPDTPYKITVIAVYED--GDGGHLTGNGRTVGLLPP 955
Query: 531 PELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGL 590
+H+ T ++ W P P SP+ Y I + + + LH L
Sbjct: 956 QNIHISDEWYTRFRVSWDPSP-----SPVLGYKIVYKPVGSNEPMEAFVGEMTSYTLHNL 1010
Query: 591 EPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHI 628
P++ Y +++ A +G + + LT +G+ L++
Sbjct: 1011 NPSTTYDVNVYAQYDSGLS-------VPLTDQGTTLYL 1041
Score = 40.8 bits (94), Expect = 0.005
Identities = 55/261 (21%), Positives = 96/261 (36%), Gaps = 21/261 (8%)
Query: 345 RQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWR-PSGQAGAILPLCNTTELSCTFHLPSEA 403
R + T+ +FW+PVP G+++ Y+V ++ P + + T S
Sbjct: 411 RDVTHSTMNVFWEPVP-----GKVRKYIVRYKTPEEDVKEVEVDRSETSTSLKDLFSQTL 465
Query: 404 QEVALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEW 463
V++ A + G S P + PA T L W+ Y I W
Sbjct: 466 YTVSVSAVHDEGESPPVTAQETTRPVPAPTNLKITEVTSEGFRGTWDHGASDVSLYRITW 525
Query: 464 GLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLY-----QDTMGPSQHV 518
P +S+ +T NG L+ EN+ P +YE+ +T +Y D + S+
Sbjct: 526 A--PFGSSDKMETIL---NGDENT-LVFENLNPNTIYEVSITAIYPDESESDDLIGSERT 579
Query: 519 YAYSQEMAPSHAP-ELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAI 577
AP P L + + ++W P + K +T+ + + +
Sbjct: 580 LPILTTQAPKSGPRNLQVYNATSNSLTVKWDPASGRVQKYRITYQP---STGEGNEQTTT 636
Query: 578 LNASSRGFVLHGLEPASLYHI 598
+ VL L+P + Y I
Sbjct: 637 IGGRQNSVVLQKLKPDTPYTI 657
Score = 34.3 bits (77), Expect = 0.46
Identities = 61/286 (21%), Positives = 105/286 (36%), Gaps = 35/286 (12%)
Query: 327 LRTTERA---PTVRLDTWWRQRQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGA 383
L+ TE+ P V L+ + + P T+ + W+PV G GY++S++P
Sbjct: 302 LKGTEKTLPVPVVSLNIY----DVGPTTMHVQWQPV------GGATGYILSYKPVKDTEP 351
Query: 384 ILPL-----CNTTELSCTFHLPSEAQEVALVAYNSAGTSRPTPVVFSESRGPALTRLHAM 438
P ++ T +P+ V + A TS P V P L
Sbjct: 352 TRPKEVRLGPTVNDMQLTDLVPNTEYAVTVQAVLHDLTSEPVTVREVTLPLPRPQDLKLR 411
Query: 439 ARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQ 498
++ V WEP + Y++ + + +E + T LK+
Sbjct: 412 DVTHSTMNVFWEPVPGKVRKYIVRY------KTPEEDVKEVEVDRSETSTSLKDLFSQ-T 464
Query: 499 LYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAP-ELHLKHIGKTWAQLEWVPEPPELGKS 557
LY + V+ ++ + G S V A + P AP L + + + W + G S
Sbjct: 465 LYTVSVSAVHDE--GESPPVTA-QETTRPVPAPTNLKITEVTSEGFRGTW-----DHGAS 516
Query: 558 PLTHYTIFWTN-AQNQSFSAILNASSRGFVLHGLEPASLYHIHLMA 602
++ Y I W + ILN V L P ++Y + + A
Sbjct: 517 DVSLYRITWAPFGSSDKMETILNGDENTLVFENLNPNTIYEVSITA 562
>gi|93141047 collagen, type XII, alpha 1 long isoform precursor [Homo
sapiens]
Length = 3063
Score = 53.5 bits (127), Expect = 7e-07
Identities = 106/518 (20%), Positives = 187/518 (36%), Gaps = 75/518 (14%)
Query: 122 PPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQT------QGDSIL 175
P + P NL + N T++SL +W+P T + GN QT Q +L
Sbjct: 1752 PKSGPRNLQ-VYNATSNSLTVKWDPASGRVQKYRITYQPSTGEGNEQTTTIGGRQNSVVL 1810
Query: 176 DCVPKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTM 235
+ D + + + G M+ + P++ V+ LR
Sbjct: 1811 QKLKPDTPYTITVSSLY-------------PDGEGGRMTGRGKTKPLNTVR----NLRVY 1853
Query: 236 DPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELC 295
DPS L + W+ + ++ +L + P G + P+P L
Sbjct: 1854 DPSTST-------LNVRWDHAEGN---PRQYKLFYAPAAGGPEELV--PIPGNTNYAILR 1901
Query: 296 GLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLF 355
L P T+YT+ + + G + + +R R V T P ++ +
Sbjct: 1902 NLQPDTSYTVTVVPVYTEGDGGRTSDTGRTLMRGLARNVQVYNPT--------PNSLDVR 1953
Query: 356 WKPVPLEEDSGRIQGYVVSWRP---SGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYN 412
W P P G + Y V + P + + +I+ NT + +P V LVA
Sbjct: 1954 WDPAP-----GPVLQYRVVYSPVDGTRPSESIVVPGNTRMVHLERLIPDTLYSVNLVALY 2008
Query: 413 SAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWG--LGPPSA 470
S G P+P L +SL V W+ + Q Y I + +G P
Sbjct: 2009 SDGEGNPSPAQGRTLPRSGPRNLRVFGETTNSLSVAWDHADGPVQQYRIIYSPTVGDPID 2068
Query: 471 SNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHA 530
+ GR +L+ ++P Y+I V +Y+D G H+ + +
Sbjct: 2069 EYTTVP------GRRNNVILQP-LQPDTPYKITVIAVYED--GDGGHLTGNGRTVGLLPP 2119
Query: 531 PELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGL 590
+H+ T ++ W P P SP+ Y I + + + LH L
Sbjct: 2120 QNIHISDEWYTRFRVSWDPSP-----SPVLGYKIVYKPVGSNEPMEAFVGEMTSYTLHNL 2174
Query: 591 EPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHI 628
P++ Y +++ A +G + + LT +G+ L++
Sbjct: 2175 NPSTTYDVNVYAQYDSGLS-------VPLTDQGTTLYL 2205
Score = 40.8 bits (94), Expect = 0.005
Identities = 55/261 (21%), Positives = 96/261 (36%), Gaps = 21/261 (8%)
Query: 345 RQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWR-PSGQAGAILPLCNTTELSCTFHLPSEA 403
R + T+ +FW+PVP G+++ Y+V ++ P + + T S
Sbjct: 1575 RDVTHSTMNVFWEPVP-----GKVRKYIVRYKTPEEDVKEVEVDRSETSTSLKDLFSQTL 1629
Query: 404 QEVALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEW 463
V++ A + G S P + PA T L W+ Y I W
Sbjct: 1630 YTVSVSAVHDEGESPPVTAQETTRPVPAPTNLKITEVTSEGFRGTWDHGASDVSLYRITW 1689
Query: 464 GLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLY-----QDTMGPSQHV 518
P +S+ +T NG L+ EN+ P +YE+ +T +Y D + S+
Sbjct: 1690 A--PFGSSDKMETIL---NGDENT-LVFENLNPNTIYEVSITAIYPDESESDDLIGSERT 1743
Query: 519 YAYSQEMAPSHAP-ELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAI 577
AP P L + + ++W P + K +T+ + + +
Sbjct: 1744 LPILTTQAPKSGPRNLQVYNATSNSLTVKWDPASGRVQKYRITYQP---STGEGNEQTTT 1800
Query: 578 LNASSRGFVLHGLEPASLYHI 598
+ VL L+P + Y I
Sbjct: 1801 IGGRQNSVVLQKLKPDTPYTI 1821
Score = 34.3 bits (77), Expect = 0.46
Identities = 61/286 (21%), Positives = 105/286 (36%), Gaps = 35/286 (12%)
Query: 327 LRTTERA---PTVRLDTWWRQRQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGA 383
L+ TE+ P V L+ + + P T+ + W+PV G GY++S++P
Sbjct: 1466 LKGTEKTLPVPVVSLNIY----DVGPTTMHVQWQPV------GGATGYILSYKPVKDTEP 1515
Query: 384 ILPL-----CNTTELSCTFHLPSEAQEVALVAYNSAGTSRPTPVVFSESRGPALTRLHAM 438
P ++ T +P+ V + A TS P V P L
Sbjct: 1516 TRPKEVRLGPTVNDMQLTDLVPNTEYAVTVQAVLHDLTSEPVTVREVTLPLPRPQDLKLR 1575
Query: 439 ARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQ 498
++ V WEP + Y++ + + +E + T LK+
Sbjct: 1576 DVTHSTMNVFWEPVPGKVRKYIVRY------KTPEEDVKEVEVDRSETSTSLKDLFSQ-T 1628
Query: 499 LYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAP-ELHLKHIGKTWAQLEWVPEPPELGKS 557
LY + V+ ++ + G S V A + P AP L + + + W + G S
Sbjct: 1629 LYTVSVSAVHDE--GESPPVTA-QETTRPVPAPTNLKITEVTSEGFRGTW-----DHGAS 1680
Query: 558 PLTHYTIFWTN-AQNQSFSAILNASSRGFVLHGLEPASLYHIHLMA 602
++ Y I W + ILN V L P ++Y + + A
Sbjct: 1681 DVSLYRITWAPFGSSDKMETILNGDENTLVFENLNPNTIYEVSITA 1726
>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
sapiens]
Length = 2299
Score = 52.4 bits (124), Expect = 2e-06
Identities = 45/171 (26%), Positives = 72/171 (42%), Gaps = 15/171 (8%)
Query: 444 SLWVGWEPPNPWPQGYVIEWGL---GPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLY 500
S+ + W+PP P G +I + L GP N N ++ N +++ E + PF LY
Sbjct: 1166 SVLLSWDPPVK-PNGAIISYDLTLQGP----NENYSFITSDN-----YIILEELSPFTLY 1215
Query: 501 EIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPE-LHLKHIGKTWAQLEWVPEPPELGKSPL 559
+ +GPS ++ Y+ E P P+ L L + + L+W P P G +
Sbjct: 1216 SFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKV 1275
Query: 560 THYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATN 610
+ I + I + L GLEP S Y I + A ++ G N
Sbjct: 1276 YSFKIHEHETDTIYYKNISGFKTEA-KLVGLEPVSTYSIRVSAFTKVGNGN 1325
Score = 40.4 bits (93), Expect = 0.006
Identities = 28/116 (24%), Positives = 54/116 (46%), Gaps = 5/116 (4%)
Query: 496 PFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELG 555
PF + I V+ GP + +++ PS ++ K+I + L W +PPE
Sbjct: 538 PFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYW--DPPEYP 595
Query: 556 KSPLTHYTIFWTNAQ-NQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATN 610
+THYTI+ N++F + F++ GL+ + Y + + A++ G ++
Sbjct: 596 NGKITHYTIYAMELDTNRAFQ--ITTIDNSFLITGLKKYTKYKMRVAASTHVGESS 649
Score = 37.4 bits (85), Expect = 0.054
Identities = 39/167 (23%), Positives = 70/167 (41%), Gaps = 18/167 (10%)
Query: 492 ENIRPFQLYEIIVTPL----YQDTMGPSQHVYAYSQEMAPSHAPELH-LKHIGKTWAQLE 546
+N+ + Y + +TP + DT + +Y ++E P +P ++ K++ T L
Sbjct: 1113 DNLEKYTDYILKITPSTEKGFSDTY--TAQLYIKTEEDVPETSPIINTFKNLSSTSVLLS 1170
Query: 547 WVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQA 606
W +PP + Y + N+++S I S +L L P +LY A ++
Sbjct: 1171 W--DPPVKPNGAIISYDLT-LQGPNENYSFI--TSDNYIILEELSPFTLYSFFAAARTRK 1225
Query: 607 GATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCGTAWLCCSPN 653
G S++L T + + L L L+ C WL SP+
Sbjct: 1226 GLGPSSILFFYT------DESVPLAPPQNLTLINCTSDFVWLKWSPS 1266
Score = 35.4 bits (80), Expect = 0.21
Identities = 35/183 (19%), Positives = 73/183 (39%), Gaps = 14/183 (7%)
Query: 444 SLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEII 503
S+ + W+PP +P G + + + + R Q L ++ + Y++
Sbjct: 584 SILLYWDPPE-YPNGKITHYTIYAMELDTN----RAFQITTIDNSFLITGLKKYTKYKMR 638
Query: 504 V---TPLYQDTMGPSQHVYAYSQEMAPSHAPE-LHLKHIGKTWAQLEWVPEPPELGKSPL 559
V T + + ++ ++ + E P +P+ + + + +L+W PPE +
Sbjct: 639 VAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKW--SPPEKPNGII 696
Query: 560 THYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTL 619
Y + + N N S+ +L L P +LY+I + + ++ G N L
Sbjct: 697 IAYEVLYKNIDTLYMK---NTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVR 753
Query: 620 TPE 622
T E
Sbjct: 754 TSE 756
Score = 30.0 bits (66), Expect = 8.6
Identities = 19/90 (21%), Positives = 37/90 (41%), Gaps = 9/90 (10%)
Query: 467 PPSASNSNKTWRMEQNGRATGFL------LK---ENIRPFQLYEIIVTPLYQDTMGPSQH 517
PP+ ++R+E G + L LK N+ PF +Y++ + GP +
Sbjct: 328 PPTIVTGKFSYRVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSN 387
Query: 518 VYAYSQEMAPSHAPELHLKHIGKTWAQLEW 547
+ ++ P +L L + T ++ W
Sbjct: 388 ISVFTPPDVPGAVFDLQLAEVESTQVRITW 417
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 52.0 bits (123), Expect = 2e-06
Identities = 83/356 (23%), Positives = 139/356 (39%), Gaps = 39/356 (10%)
Query: 282 VGPLPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLEL-RTTERAPTVRLDT 340
VGP E + GL PA Y ++ + G +S + L L AP +
Sbjct: 721 VGP---EMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVA 777
Query: 341 WWRQRQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLP 400
R Q ++ + W+P P E +G ++GY++ +R +G G N T + L
Sbjct: 778 SGRTNQ----SIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQR-NITSPEVNYCLV 832
Query: 401 SE-----AQEVALVAYNSAGTSRPTPVVFSESRGPALT----RLHAMARDPHSLWVGWEP 451
++ E+ + AYN AG + V + T + A + ++ W P
Sbjct: 833 TDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNP 892
Query: 452 P-----NPWPQGY-VIEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVT 505
P N QGY ++ W P A + T + +G G + N++ F Y +
Sbjct: 893 PPQQFINGINQGYKLLAWPADAPEAV-TVVTIAPDFHGVHHGHI--TNLKKFTAY--FTS 947
Query: 506 PLYQDTMG---PSQHVYAYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHY 562
L T G PS ++QE P L I T ++ W + P +T Y
Sbjct: 948 VLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSW--QEPLEKNGIITGY 1005
Query: 563 TIFWT--NAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAG---ATNSTV 613
I W + + LN+++ + + GL + Y I + A + G T+ST+
Sbjct: 1006 QISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTI 1061
Score = 50.4 bits (119), Expect = 6e-06
Identities = 84/405 (20%), Positives = 158/405 (39%), Gaps = 37/405 (9%)
Query: 231 MLRTMDPSPEAAPPQAGC-------LQLCWEPWQPGLHINQKCE---LRHKPQRGEASWA 280
+++T+ P+ AP L+L W P P N E R K R + +
Sbjct: 1165 VIQTLQAPPDVAPTSVTVRTASETSLRLRWVPL-PDSQYNGNPESVGYRIKYWRSDLQSS 1223
Query: 281 LVGPLPLEALQYELC--GLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRL 338
V + + L+ E L Y LQ++ G WS+ + RT E P+
Sbjct: 1224 AVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSE---VVRGRTRESVPSAAP 1280
Query: 339 DTWWRQRQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSG---QAGAILPLCNTTELSC 395
+ + + + L W VP ++ +G I GY + +R + + + N T+ +
Sbjct: 1281 ENVSAEA-VSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSAL 1339
Query: 396 TFHLPS-EAQEVALVAYNSAGTSRP-TPVVFSESR----GPALTRLHAMARDPHSLWVGW 449
L E+ ++A+ G P TP++ ++ GP + + R S+ + W
Sbjct: 1340 LAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVR-LTSVRIVW 1398
Query: 450 EPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQ 509
+PP P G ++ + + AS+S T+ + G ++ P Y ++ +
Sbjct: 1399 QPPEE-PNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTR 1457
Query: 510 DTMGPSQHVYAYSQEMAPSHAPELHL----KHIGKTWAQLEWVPEPPELGKSPLTHYTI- 564
G + E AP L + +L+WVP G SP+ ++T+
Sbjct: 1458 QGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSD--GASPIRYFTMQ 1515
Query: 565 --FWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAG 607
+ Q++S+ ++ + V+ L P + Y + L A + G
Sbjct: 1516 VRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIG 1560
Score = 46.6 bits (109), Expect = 9e-05
Identities = 79/347 (22%), Positives = 138/347 (39%), Gaps = 21/347 (6%)
Query: 288 EALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQL 347
+A E+ L P T Y +++ + P S +SPS + T +AP T R
Sbjct: 1129 DAQMLEIPNLTPYTHYRFRMKQVNIVGP---SPYSPSSRVIQTLQAPPDVAPTSVTVRTA 1185
Query: 348 DPRTVQLFWKPVPLEEDSGRIQ--GYVVS-WRPSGQAGAILP-LCNTTELSCTFHLPSE- 402
+++L W P+P + +G + GY + WR Q+ A+ + + E T E
Sbjct: 1186 SETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEW 1245
Query: 403 -AQEVALVAYNSAGTSRPTPVVFSESR----GPALTRLHAMARDPHSLWVGW-EPPNPWP 456
E+ + A+N+ G + VV +R A + A A + + W P
Sbjct: 1246 MEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQ 1305
Query: 457 QGYVIEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMG-PS 515
G ++ + + + + G T L +R F LYE+ V + G PS
Sbjct: 1306 NGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPS 1365
Query: 516 QH-VYAYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQN--Q 572
+ +++ AP L + T ++ W +PPE + Y I + A +
Sbjct: 1366 TPLILERTKDDAPGPPVRLVFPEVRLTSVRIVW--QPPEEPNGIILGYQIAYRLASSSPH 1423
Query: 573 SFSAI-LNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMT 618
+F+ + + A+ R F L P S Y L A ++ G T++T
Sbjct: 1424 TFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVIT 1470
Score = 37.4 bits (85), Expect = 0.054
Identities = 75/328 (22%), Positives = 130/328 (39%), Gaps = 60/328 (18%)
Query: 291 QYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELR--TTERA--PTVRLDTWWRQRQ 346
Q+ L P +AY ++ W LE TTE+ P + Q +
Sbjct: 1436 QFTATDLAPESAYIFRLSAKTR------QGWGEPLEATVITTEKRERPAPPRELLVPQAE 1489
Query: 347 LDPRTVQLFWKPVPLEEDSGRIQGYVVSWR--PSGQAGAILPLCNTTELSCTFHL--PSE 402
+ R+++L W VP + + I+ + + R P G+ + +C P
Sbjct: 1490 VTARSLRLQW--VPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFT 1547
Query: 403 AQEVALVAYNSAGTSRPTPVVFSESRGPALTRLH--------AMARDPH---SLWVGWEP 451
+ ++ L A N G S FS S A+T L +++ PH S+ + W+P
Sbjct: 1548 SYKLRLKATNDIGDSD-----FS-SETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQP 1601
Query: 452 P-----NPWPQGYVI-------EWGLGPPSASNSN-----------KTWRMEQNGRATGF 488
P N QGY I E G G + + N +++ + +
Sbjct: 1602 PRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTM 1661
Query: 489 LLKENIRPFQLYEIIVTPLYQDTMGP-SQHVYAYSQEMAPSHAPELHLKHIGKTWAQLE- 546
+++ ++ YE+I+T P S V + E AP+ AP+ +++ T +QLE
Sbjct: 1662 CELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQ-NVQVTPLTASQLEV 1720
Query: 547 -WVPEPPELGKSPLTHYTIFWTNAQNQS 573
W P PPE + Y I++ A +Q+
Sbjct: 1721 TWDPPPPESQNGNIQGYKIYYWEADSQN 1748
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 51.2 bits (121), Expect = 4e-06
Identities = 83/373 (22%), Positives = 150/373 (40%), Gaps = 48/373 (12%)
Query: 292 YELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRT 351
Y + GL T Y+ ++ PG + P + +RT P+ + + + ++
Sbjct: 594 YTINGLKKYTEYSFRVVAYNKHGPGVST---PDVAVRTLSDVPSAAPQNLSLEVR-NSKS 649
Query: 352 VQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAIL-PLCNTTELSCTFHLPSEAQE--VAL 408
+ + W+P +G+I GY + +R + + + L + T+LS E +
Sbjct: 650 IMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRV 709
Query: 409 VAYNSAGTSRPTPVVFSESRGPAL--TRLHAMARDPH------SLWVGWEPP---NPWPQ 457
A GT T + +E+ L TR+ + H S+ V W PP N +
Sbjct: 710 AALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVR 769
Query: 458 GYVIEWGLGPPSASN-----SNKTWRMEQNGRATGFLLK----ENI-RPFQLYEIIVTPL 507
GY I +G+G P A + + +E ++ +++ N+ LYE VT
Sbjct: 770 GYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRP 829
Query: 508 YQDTMGPSQHVYAYSQEMAPSHAPELH--------LKH--IGKTWAQLEWVPEPPELGKS 557
+ DT V P P + L H I TWA +P+ ++ S
Sbjct: 830 HTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWAD-NSLPKHQKITDS 888
Query: 558 PLTHYTIFW-TNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTL 616
+YT+ W TN + NA++ +++ GL+P +LY +M G +ST
Sbjct: 889 --RYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTK--GRRSST---- 940
Query: 617 MTLTPEGSELHII 629
++T G+ ++
Sbjct: 941 WSMTAHGTTFELV 953
>gi|219842266 usherin isoform B [Homo sapiens]
Length = 5202
Score = 50.8 bits (120), Expect = 5e-06
Identities = 78/343 (22%), Positives = 136/343 (39%), Gaps = 37/343 (10%)
Query: 291 QYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQL--D 348
Q+ + GL P T Y+ + + P L +T + AP W R + +
Sbjct: 3642 QHTVTGLQPYTNYSFTLTACT---SAGCTSSEPFLG-QTLQAAPE---GVWVTPRHIIIN 3694
Query: 349 PRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHL--PSEAQEV 406
TV+L+W +P E+ +G + Y +S + G +L L + E + T P+
Sbjct: 3695 STTVELYWS-LP-EKPNGLVSQYQLS-----RNGNLLFLGGSEEQNFTDKNLEPNSRYTY 3747
Query: 407 ALVAYNSAGTSRP------TPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYV 460
L G+S TP+ E P + P+S++V W PP
Sbjct: 3748 KLEVKTGGGSSASDDYIVQTPMSTPEEIYPPY---NITVIGPYSIFVAWIPPGILIPEIP 3804
Query: 461 IEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYA 520
+E+ + S + + + + L EN+ PF YEI + + G S ++
Sbjct: 3805 VEYNVLLNDGSVTPLAFSVGHHQST----LLENLTPFTQYEIRIQACQNGSCGVSSRMFV 3860
Query: 521 YSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNA--QNQSFSAIL 578
+ E AP LK +G +++W+ PPE + +Y I+ A + +S +
Sbjct: 3861 KTPEAAPMDLNSPVLKALGSACIEIKWM--PPEKPNGIIINYFIYRRPAGIEEESVLFVW 3918
Query: 579 NASSRGFVLHG--LEPASLYHIHLMAASQAGATNSTVLTLMTL 619
+ + F+ G L P +LY + A + G+ S TL
Sbjct: 3919 SEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQTL 3961
Score = 40.4 bits (93), Expect = 0.006
Identities = 45/190 (23%), Positives = 80/190 (42%), Gaps = 15/190 (7%)
Query: 447 VGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGRATGFLLK-ENIRPFQLYEIIVT 505
+ W PP P G +I + + A ++ + A F+ + + +RPF LYE V
Sbjct: 3885 IKWMPPEK-PNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVR 3943
Query: 506 PLYQDTMGPSQHVYAYSQ--EMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHY- 562
++ G + +++ +Q E P P + L W PE ++HY
Sbjct: 3944 AC--NSKGSVESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTK--PESPNGIISHYR 3999
Query: 563 TIFWTNAQNQSFSA------ILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTL 616
++ + +F++ + +S L+GLEP + Y I ++AA+ AG S +
Sbjct: 4000 VVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLI 4059
Query: 617 MTLTPEGSEL 626
TL S L
Sbjct: 4060 QTLESSPSGL 4069
Score = 39.7 bits (91), Expect = 0.011
Identities = 65/297 (21%), Positives = 112/297 (37%), Gaps = 33/297 (11%)
Query: 347 LDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTEL----SCTFHLPSE 402
L+P VQ+ WKP ++ +G I Y + + L N T T +P
Sbjct: 2735 LEPDAVQVTWKPPLIQ--NGDILSYEIH-----MPDPHITLTNVTSAVLSQKVTHLIPFT 2787
Query: 403 AQEVALVAYNSAG-------TSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPW 455
V +VA + S PT V + + L + + + W+PP+
Sbjct: 2788 NYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQPPSK- 2846
Query: 456 PQGYVIEWGL-----GPPSASNSNKT---WRMEQNGRATGFLLKEN-IRPFQLYEIIVTP 506
P G + + L P ASN + W +G T +L ++ + F YE ++
Sbjct: 2847 PNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSG--TQWLYEDKGLSRFTTYEYMLFV 2904
Query: 507 LYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFW 566
PS+ V + P L + T + W + + + +YT+FW
Sbjct: 2905 HNSVGFTPSREVTVTTLAGLPERGANLTASVLNHTAIDVRWAKPTVQDLQGEVEYYTLFW 2964
Query: 567 TNA-QNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPE 622
++A N S + + +S V+ L+P + Y I + + + NS L T E
Sbjct: 2965 SSATSNDSLKILPDVNSH--VIGHLKPNTEYWIFISVFNGVHSINSAGLHATTCDGE 3019
Score = 38.9 bits (89), Expect = 0.019
Identities = 39/173 (22%), Positives = 66/173 (38%), Gaps = 19/173 (10%)
Query: 456 PQGYVIEWGLGPPSASNSN-KTWRMEQNGRATGFLLK--------ENIRPFQLYEIIVTP 506
PQ +I W PP SN +++R+++N F E + PF Y +
Sbjct: 4278 PQKLLISWI--PPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQA 4335
Query: 507 LYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFW 566
S+ + E APS L + T + W PP + +T Y + +
Sbjct: 4336 CTSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCW--SPPTVQNGKITKYLVRY 4393
Query: 567 TNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTL 619
N ++ L ++ L+P S Y+ L+A + G T S + T+
Sbjct: 4394 DNKES------LAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTM 4440
Score = 33.9 bits (76), Expect = 0.60
Identities = 39/156 (25%), Positives = 58/156 (37%), Gaps = 16/156 (10%)
Query: 483 GRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGKTW 542
G + F KE I+PFQ Y + S V A + + P + +
Sbjct: 3546 GTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITALSAVA 3605
Query: 543 AQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASS---RGFVLHGLEPASLYHIH 599
L W PE + Y I Q +++ + R + GL+P + Y
Sbjct: 3606 LHLSW--SVPEKSNGVIKEYQI------RQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFT 3657
Query: 600 LMAASQAGATNSTVLTLMTL--TPEG---SELHIIL 630
L A + AG T+S TL PEG + HII+
Sbjct: 3658 LTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIII 3693
Score = 33.9 bits (76), Expect = 0.60
Identities = 61/281 (21%), Positives = 99/281 (35%), Gaps = 34/281 (12%)
Query: 351 TVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVA 410
++++ WKP +G+I+ Y + + G I+ T P + A
Sbjct: 4459 SIEITWKPP--RNPNGQIRSYELR-----RDGTIVYTGLETRYRDFTLTPGVEYSYTVTA 4511
Query: 411 YNSAG-------TSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEW 463
NS G R +P S P L AR P + V W+PP G +I +
Sbjct: 4512 SNSQGGILSPLVKDRTSPSAPSGMEPPKL-----QARGPQEILVNWDPPVR-TNGDIINY 4565
Query: 464 GLGPPSA-SNSNKTWRMEQNGRATGF--LLKENIRPFQLYEIIVTPLYQDTMGPSQHVYA 520
L K + + G + ++PF YEI + S +
Sbjct: 4566 TLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASSDWTFI 4625
Query: 521 YSQEMAPSHAPELHLK-----HIGKTWAQLEWVPEPPELGKSPLTHYTIF----WTNAQN 571
+ E+AP P HL+ + L W GK + +Y ++ T +
Sbjct: 4626 QTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGK--VLYYELYRRQIATQPRK 4683
Query: 572 QSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNST 612
+ I N SS F+ L P + Y + A + AG S+
Sbjct: 4684 SNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSS 4724
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 50.8 bits (120), Expect = 5e-06
Identities = 82/320 (25%), Positives = 125/320 (39%), Gaps = 35/320 (10%)
Query: 323 PSLELRTTERAPTV---RLDTWWRQRQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSG 379
PS ++RT E P V ++ R + + W PVP E +G GYVV++RP G
Sbjct: 689 PSEKVRTEEAVPEVPPSEVNGGGGSRS----ELVITWDPVPEELQNGEGFGYVVAFRPLG 744
Query: 380 QAGAILPLCNTTELSCTFH-----LPSEAQEVALVAYNSAGTSRPTPV--VFSESRGPAL 432
I + + + +P EV + YN+ G +PV VFS P +
Sbjct: 745 VTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTV 804
Query: 433 TRLHAMARDPHS-----LW--VGWEPPNPWPQGYVIEW--GLGPPSASNSNKTWRMEQNG 483
A S W + W+ N GY + + G G +S+ K E +
Sbjct: 805 APSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMKVAGNETSA 864
Query: 484 RATGFLLKENIRPFQLYEIIVTPLYQDTMGP-SQHVYAYSQEMAPSHAPELHLKHIGKTW 542
R G LK N+ Y V GP S V +++ PS P + + T
Sbjct: 865 RLRG--LKSNL----AYYTAVRAYNSAGAGPFSATVNVTTKKTPPSQPPGNVVWNATDTK 918
Query: 543 AQLEWVPEPPELGKSPLTHYTIFW-TNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLM 601
L W +S +T Y +F+ T++QN N +S VL E Y I +
Sbjct: 919 VLLNWEQVKAMENESEVTGYKVFYRTSSQNNVQVLNTNKTSAELVLPIKED---YIIEVK 975
Query: 602 AASQAG-ATNSTVLTLMTLT 620
A + G T+S + + +T
Sbjct: 976 ATTDGGDGTSSEQIRIPRIT 995
>gi|22212918 ciliary neurotrophic factor receptor preproprotein
[Homo sapiens]
Length = 372
Score = 50.8 bits (120), Expect = 5e-06
Identities = 77/326 (23%), Positives = 119/326 (36%), Gaps = 56/326 (17%)
Query: 9 LTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQILWRL-GA 67
L AA ++ S +E H+ LG +T C + + + WR+ G
Sbjct: 13 LAAAAAVVYAQRHSPQEAPHVQYE----RLGSDVTLPC------GTANWDAAVTWRVNGT 62
Query: 68 ELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAGYPPAIPH 127
+L P L +G+Q + L L + L C + +S + QV L G PP P
Sbjct: 63 DLAPD-----LLNGSQ---LVLHGLELGHSGLYACFH-RDSWHLRHQVLLHVGLPPREPV 113
Query: 128 NLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPKDG--QSH 185
LSC N C W T++P +F + G I+ C KD ++
Sbjct: 114 -LSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVL--------HGSKIMVC-EKDPALKNR 163
Query: 186 CCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQ 245
C I HL + + NALG + + + D +VK +PP P P
Sbjct: 164 CHIRYMHLFSTIKYKVSISVSNALGHN-ATAITFDEFTIVKPDPPENVVARP----VPSN 218
Query: 246 AGCLQLCWE---PWQPGLHINQKCELRHKP------QRGEASWALVGPLPLEALQYELCG 296
L++ W+ W K LR++P Q E S + + +
Sbjct: 219 PRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELS---------DGTAHTITD 269
Query: 297 LLPATAYTLQIRCIRWPLPGHWSDWS 322
Y +Q+ + G WSDWS
Sbjct: 270 AYAGKEYIIQVAAKDNEI-GTWSDWS 294
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.444
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,539,003
Number of Sequences: 37866
Number of extensions: 2101467
Number of successful extensions: 5626
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 97
Number of HSP's that attempted gapping in prelim test: 5108
Number of HSP's gapped (non-prelim): 495
length of query: 783
length of database: 18,247,518
effective HSP length: 110
effective length of query: 673
effective length of database: 14,082,258
effective search space: 9477359634
effective search space used: 9477359634
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.