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Search of human proteins with 239755742
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239755742 PREDICTED: similar to DEAD/H (Asp-Glu-Ala-Asp/His)
box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae) [Homo
sapiens]
(282 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239755742 PREDICTED: similar to DEAD/H (Asp-Glu-Ala-Asp/His) ... 561 e-160
gi|212549538 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12 [Ho... 319 2e-87
gi|100913204 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 iso... 317 7e-87
gi|100913202 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 iso... 317 7e-87
gi|132566527 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 iso... 317 7e-87
gi|148746195 trichohyalin [Homo sapiens] 47 2e-05
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 46 4e-05
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 46 4e-05
gi|22758136 MAP7 domain containing 2 [Homo sapiens] 44 2e-04
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 42 8e-04
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 42 8e-04
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 42 8e-04
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 42 8e-04
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 42 8e-04
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 42 8e-04
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 42 8e-04
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 42 8e-04
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 42 8e-04
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 42 8e-04
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 42 8e-04
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 42 8e-04
gi|4505257 moesin [Homo sapiens] 41 0.001
gi|92859701 myosin VI [Homo sapiens] 41 0.001
gi|169208122 PREDICTED: hypothetical protein isoform 1 [Homo sap... 41 0.001
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo... 40 0.002
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor... 40 0.002
gi|10863889 squamous cell carcinoma antigen recognized by T cell... 40 0.002
gi|56549694 enabled homolog isoform a [Homo sapiens] 40 0.003
gi|39930375 enabled homolog isoform b [Homo sapiens] 40 0.003
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 39 0.004
>gi|239755742 PREDICTED: similar to DEAD/H (Asp-Glu-Ala-Asp/His) box
polypeptide 11 (CHL1-like helicase homolog, S.
cerevisiae) [Homo sapiens]
Length = 282
Score = 561 bits (1446), Expect = e-160
Identities = 282/282 (100%), Positives = 282/282 (100%)
Query: 1 MRSGGGCSGSLSQRGPASFKFSGVCPDSRGLAFSVAILPAKKGKSLSLICGALSWLRDFE 60
MRSGGGCSGSLSQRGPASFKFSGVCPDSRGLAFSVAILPAKKGKSLSLICGALSWLRDFE
Sbjct: 1 MRSGGGCSGSLSQRGPASFKFSGVCPDSRGLAFSVAILPAKKGKSLSLICGALSWLRDFE 60
Query: 61 QKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDL 120
QKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDL
Sbjct: 61 QKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDL 120
Query: 121 VNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEW 180
VNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEW
Sbjct: 121 VNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEW 180
Query: 181 LEQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQRTRPSSVLS 240
LEQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQRTRPSSVLS
Sbjct: 181 LEQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQRTRPSSVLS 240
Query: 241 EDLLMQRAVAKHPALLPSQMSSSPLRPGSEWMRMRMTWRKNT 282
EDLLMQRAVAKHPALLPSQMSSSPLRPGSEWMRMRMTWRKNT
Sbjct: 241 EDLLMQRAVAKHPALLPSQMSSSPLRPGSEWMRMRMTWRKNT 282
>gi|212549538 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12 [Homo
sapiens]
Length = 906
Score = 319 bits (818), Expect = 2e-87
Identities = 163/173 (94%), Positives = 163/173 (94%)
Query: 39 PAKKGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT 98
P GKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT
Sbjct: 45 PTGTGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT 104
Query: 99 PRPAGEPAWVTQFVQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEE 158
PRPAGEPAWVTQFVQKKEERDLVNRLK EQARRKQREERLQQLQHRVQLKYAAKRLRQEE
Sbjct: 105 PRPAGEPAWVTQFVQKKEERDLVNRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEE 164
Query: 159 EETENLLRLSREMLETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGAPSD 211
EE ENLLRLSREMLETGPEAE EQLESGEEELVLAEYESDEEKKVASG D
Sbjct: 165 EERENLLRLSREMLETGPEAERPEQLESGEEELVLAEYESDEEKKVASGVDED 217
>gi|100913204 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
isoform 2 [Homo sapiens]
Length = 856
Score = 317 bits (812), Expect = 7e-87
Identities = 162/173 (93%), Positives = 163/173 (94%)
Query: 39 PAKKGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT 98
P GKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT
Sbjct: 45 PTGTGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT 104
Query: 99 PRPAGEPAWVTQFVQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEE 158
PRPAGEPAWVTQFVQKKEERDLV+RLK EQARRKQREERLQQLQHRVQLKYAAKRLRQEE
Sbjct: 105 PRPAGEPAWVTQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEE 164
Query: 159 EETENLLRLSREMLETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGAPSD 211
EE ENLLRLSREMLETGPEAE LEQLESGEEELVLAEYESDEEKKVAS D
Sbjct: 165 EERENLLRLSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDED 217
>gi|100913202 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
isoform 1 [Homo sapiens]
Length = 906
Score = 317 bits (812), Expect = 7e-87
Identities = 162/173 (93%), Positives = 163/173 (94%)
Query: 39 PAKKGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT 98
P GKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT
Sbjct: 45 PTGTGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT 104
Query: 99 PRPAGEPAWVTQFVQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEE 158
PRPAGEPAWVTQFVQKKEERDLV+RLK EQARRKQREERLQQLQHRVQLKYAAKRLRQEE
Sbjct: 105 PRPAGEPAWVTQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEE 164
Query: 159 EETENLLRLSREMLETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGAPSD 211
EE ENLLRLSREMLETGPEAE LEQLESGEEELVLAEYESDEEKKVAS D
Sbjct: 165 EERENLLRLSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDED 217
>gi|132566527 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
isoform 3 [Homo sapiens]
Length = 970
Score = 317 bits (812), Expect = 7e-87
Identities = 162/173 (93%), Positives = 163/173 (94%)
Query: 39 PAKKGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT 98
P GKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT
Sbjct: 45 PTGTGKSLSLICGALSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGT 104
Query: 99 PRPAGEPAWVTQFVQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEE 158
PRPAGEPAWVTQFVQKKEERDLV+RLK EQARRKQREERLQQLQHRVQLKYAAKRLRQEE
Sbjct: 105 PRPAGEPAWVTQFVQKKEERDLVDRLKAEQARRKQREERLQQLQHRVQLKYAAKRLRQEE 164
Query: 159 EETENLLRLSREMLETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGAPSD 211
EE ENLLRLSREMLETGPEAE LEQLESGEEELVLAEYESDEEKKVAS D
Sbjct: 165 EERENLLRLSREMLETGPEAERLEQLESGEEELVLAEYESDEEKKVASRVDED 217
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 46.6 bits (109), Expect = 2e-05
Identities = 42/163 (25%), Positives = 77/163 (47%), Gaps = 21/163 (12%)
Query: 57 RDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKE 116
RD E+++RE +L E + +++ L R E + +++E
Sbjct: 478 RDQEEERRERWLKLEEEERREQQERREQQL-------------RREQEERREQRLKRQEE 524
Query: 117 ERDLVNRLKVEQARRKQREERLQQL-----QHRVQLKYAAKRLRQEEEE-TENLLRLSRE 170
E L RL+ EQ R+++EER +QL + R++ + +RL++E+EE + LL+ E
Sbjct: 525 EERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE 584
Query: 171 MLETGPEAEWLEQLES--GEEELVLAEYESDEEKKVASGAPSD 211
+ + E E+LE EE+ E E E+++ P +
Sbjct: 585 RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEE 627
Score = 43.5 bits (101), Expect = 2e-04
Identities = 26/92 (28%), Positives = 49/92 (53%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREML 172
Q++E R+ + +Q RR+Q+EER +Q R Q + ++LR+E+EE +L RE
Sbjct: 310 QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQE 369
Query: 173 ETGPEAEWLEQLESGEEELVLAEYESDEEKKV 204
E E + + + E+ + E + E+++
Sbjct: 370 EERREQQLRREQQLRREQQLRREQQLRREQQL 401
Score = 43.1 bits (100), Expect = 3e-04
Identities = 29/94 (30%), Positives = 47/94 (50%)
Query: 110 QFVQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSR 169
Q + +EE LK+E+ R++++ER +Q R Q + +RL+++EEE RL
Sbjct: 475 QLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRS 534
Query: 170 EMLETGPEAEWLEQLESGEEELVLAEYESDEEKK 203
E + E EQL EEE L + ++ K
Sbjct: 535 EQQLRREQEERREQLLKREEEKRLEQERREQRLK 568
Score = 39.3 bits (90), Expect = 0.004
Identities = 30/95 (31%), Positives = 50/95 (52%), Gaps = 9/95 (9%)
Query: 110 QFVQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSR 169
Q ++++EE+ L + ++ +R+Q EER QL R + + + R++EE E RL R
Sbjct: 548 QLLKREEEKRLEQERREQRLKREQ-EERRDQLLKREEERRQQRLKREQEERLEQ--RLKR 604
Query: 170 EMLETGPEAEWLEQLESGEEELVLAEYESDEEKKV 204
E E E LEQ E E+ L E E + +++
Sbjct: 605 E------EVERLEQEERREQRLKREEPEEERRQQL 633
Score = 39.3 bits (90), Expect = 0.004
Identities = 29/91 (31%), Positives = 44/91 (48%), Gaps = 6/91 (6%)
Query: 108 VTQFVQKKEERDLVNRLKVEQARRKQ------REERLQQLQHRVQLKYAAKRLRQEEEET 161
V + Q++ + R + E+ RR+Q +EER QQ R Q + +RL++EEEE
Sbjct: 607 VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666
Query: 162 ENLLRLSREMLETGPEAEWLEQLESGEEELV 192
RL RE E E E E+ + E +
Sbjct: 667 RLEQRLKREHEEERREQELAEEEQEQARERI 697
Score = 38.9 bits (89), Expect = 0.005
Identities = 26/96 (27%), Positives = 50/96 (52%), Gaps = 2/96 (2%)
Query: 110 QFVQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKR--LRQEEEETENLLRL 167
Q +++++E L RLK E+ R ++EER +Q R + + ++ L+ EE+E +L
Sbjct: 588 QRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQL 647
Query: 168 SREMLETGPEAEWLEQLESGEEELVLAEYESDEEKK 203
RE E + E+ E E+ + E+E + ++
Sbjct: 648 RREQQERREQRLKREEEEERLEQRLKREHEEERREQ 683
Score = 37.7 bits (86), Expect = 0.011
Identities = 27/93 (29%), Positives = 48/93 (51%), Gaps = 1/93 (1%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREML 172
Q++ R+ R K E+ RR+Q+EER +Q + R Q + ++ + E+E +L RE
Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE 356
Query: 173 ETGPEAEW-LEQLESGEEELVLAEYESDEEKKV 204
E E + EQ E E+ + E + E+++
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQL 389
Score = 36.6 bits (83), Expect = 0.025
Identities = 28/93 (30%), Positives = 46/93 (49%), Gaps = 2/93 (2%)
Query: 114 KKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRL--SREM 171
K+EE RLK EQ R ++ + ++++ Q + +RL++EE E E +L S E
Sbjct: 580 KREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQ 639
Query: 172 LETGPEAEWLEQLESGEEELVLAEYESDEEKKV 204
E + EQ E E+ L E E E+++
Sbjct: 640 EERRQQQLRREQQERREQRLKREEEEERLEQRL 672
Score = 36.6 bits (83), Expect = 0.025
Identities = 24/84 (28%), Positives = 44/84 (52%)
Query: 114 KKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLE 173
+++ RD R ++E+ R+++R + + QL+ + L++EEEE + R R E
Sbjct: 866 QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQE 925
Query: 174 TGPEAEWLEQLESGEEELVLAEYE 197
+ EQL+ EE+L+ E E
Sbjct: 926 QERQYREEEQLQQEEEQLLREERE 949
Score = 36.2 bits (82), Expect = 0.033
Identities = 22/91 (24%), Positives = 48/91 (52%), Gaps = 2/91 (2%)
Query: 115 KEERDLVNRLKVEQARRKQREE--RLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREML 172
+EE + + +L+ ++ RR+++EE + Q+L+ QL+ + R+E++E + RE
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQ 331
Query: 173 ETGPEAEWLEQLESGEEELVLAEYESDEEKK 203
E E + + E E+ + E E + ++
Sbjct: 332 EERREQQLRREQEERREQQLRREQEEERREQ 362
Score = 36.2 bits (82), Expect = 0.033
Identities = 24/91 (26%), Positives = 45/91 (49%), Gaps = 7/91 (7%)
Query: 107 WVTQFVQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLR 166
W Q+ +K E + +L E+ +++ +ER +Q + +L+ ++L EE ET
Sbjct: 1016 WERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQE 1075
Query: 167 LSREMLETGPEAEWLEQLESGEEELVLAEYE 197
L R+ + E+L+ EE+L+ E E
Sbjct: 1076 LERQYRKE-------EELQQEEEQLLREEPE 1099
Score = 36.2 bits (82), Expect = 0.033
Identities = 28/95 (29%), Positives = 48/95 (50%), Gaps = 14/95 (14%)
Query: 114 KKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEE-----ETENLLRLS 168
+++ERD R + +Q RR++RE + Q + +++ + ++ R+EE+ E E L R
Sbjct: 1685 RRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE 1744
Query: 169 --REMLETGPEAEWLEQLESGEEELVLAEYESDEE 201
R++LE EQL EE L E D +
Sbjct: 1745 RYRKILEE-------EQLRPEREEQQLRRQERDRK 1772
Score = 35.8 bits (81), Expect = 0.043
Identities = 29/92 (31%), Positives = 45/92 (48%), Gaps = 6/92 (6%)
Query: 113 QKKEERDLVNRLKVEQARRK-QREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREM 171
+++EE RL+ EQ R+ Q EER +Q + R + +R Q+EE E LR RE
Sbjct: 289 ERQEEEQQQQRLRREQQLRRKQEEERREQQEER---REQQERREQQEERREQQLR--REQ 343
Query: 172 LETGPEAEWLEQLESGEEELVLAEYESDEEKK 203
E + EQ E E+ + E E + ++
Sbjct: 344 EERREQQLRREQEEERREQQLRREQEEERREQ 375
Score = 35.4 bits (80), Expect = 0.057
Identities = 32/83 (38%), Positives = 45/83 (54%), Gaps = 18/83 (21%)
Query: 113 QKKEERDLVNRLKVEQARRKQR-----EERLQQLQHRVQLKYAAKRLRQEEEETENLLRL 167
+++E RD + LK E+ RR+QR EERL+Q R ++ +RL QEE + RL
Sbjct: 570 EQEERRDQL--LKREEERRQQRLKREQEERLEQRLKREEV----ERLEQEERREQ---RL 620
Query: 168 SREMLETGPEAEWLEQLESGEEE 190
RE PE E +QL EE+
Sbjct: 621 KRE----EPEEERRQQLLKSEEQ 639
Score = 35.4 bits (80), Expect = 0.057
Identities = 36/147 (24%), Positives = 67/147 (45%), Gaps = 13/147 (8%)
Query: 60 EQKKREE-EARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEE- 117
EQ REE E R L+ +E++ L E G R + + +K+EE
Sbjct: 1031 EQLLREEREKRRLQERERQYREEEE----LQQEEEQLLGEERETRRRQELERQYRKEEEL 1086
Query: 118 RDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPE 177
+ +L E+ +++R+ER +Q + +L+ ++L +EE E L R+ E
Sbjct: 1087 QQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE--- 1143
Query: 178 AEWLEQLESGEEELVLAEYESDEEKKV 204
E+++ EE+L+ E E +++
Sbjct: 1144 ----EEVQQEEEQLLREEPEKRRRQEL 1166
Score = 35.0 bits (79), Expect = 0.074
Identities = 31/92 (33%), Positives = 45/92 (48%), Gaps = 14/92 (15%)
Query: 117 ERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-----TENLLRLSREM 171
+ + + R ++ + RRK REE+ QQ + R R+ QEEEE E +LR E
Sbjct: 206 DEEQLRRRELLELRRKGREEKQQQRRER------QDRVFQEEEEKEWRKRETVLRKEEEK 259
Query: 172 LETGPEAEWLEQLESGEEELVLAEYESDEEKK 203
L+ E E Q E EEE L + E E ++
Sbjct: 260 LQ---EEEPQRQRELQEEEEQLRKLERQELRR 288
Score = 35.0 bits (79), Expect = 0.074
Identities = 32/100 (32%), Positives = 53/100 (53%), Gaps = 10/100 (10%)
Query: 112 VQKKEERDLVNRLKVEQARRKQR-------EERLQQ-LQHRVQLKYAAKRLRQEEEETEN 163
++++ +R+ V RL+ E+ RR+QR EER QQ L+ Q + ++LR+E++E
Sbjct: 598 LEQRLKREEVERLEQEE-RREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE 656
Query: 164 LLRLSREMLETGPEAEWLEQLESGEEELVLAEYESDEEKK 203
RL RE E E + E E LAE E ++ ++
Sbjct: 657 -QRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARE 695
Score = 35.0 bits (79), Expect = 0.074
Identities = 29/98 (29%), Positives = 49/98 (50%), Gaps = 16/98 (16%)
Query: 114 KKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEE----ETENLLRLSR 169
++EER+ R + EQ R+ + EE+LQQ + ++ + KR RQE E + + L +
Sbjct: 914 QREERE--KRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEE 971
Query: 170 EMLETGPEAEWL----------EQLESGEEELVLAEYE 197
++L PE E+L+ EE+L+ E E
Sbjct: 972 QLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE 1009
Score = 34.7 bits (78), Expect = 0.097
Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 6/92 (6%)
Query: 112 VQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREM 171
V +KEE L Q ++ EE+L++L+ + +R RQEEE+ + LR +
Sbjct: 252 VLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ-----ELRRERQEEEQQQQRLR-REQQ 305
Query: 172 LETGPEAEWLEQLESGEEELVLAEYESDEEKK 203
L E E EQ E E+ E + + ++
Sbjct: 306 LRRKQEEERREQQEERREQQERREQQEERREQ 337
Score = 34.3 bits (77), Expect = 0.13
Identities = 25/91 (27%), Positives = 45/91 (49%), Gaps = 8/91 (8%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREML 172
Q++E R+ R + E+ RR+Q+ R QQL+ QL+ + R+++ E LR +++
Sbjct: 355 QEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 414
Query: 173 ETGPEAEWLEQLESGEEELVLAEYESDEEKK 203
EQ E++L + E E+K
Sbjct: 415 R--------EQQLRREQQLRREQEEERHEQK 437
Score = 34.3 bits (77), Expect = 0.13
Identities = 26/82 (31%), Positives = 42/82 (51%), Gaps = 8/82 (9%)
Query: 127 EQARRKQREERLQQLQHRVQLKYAAKRLRQEE--EETENLLRLSREMLETGPEAEWL--- 181
+Q RR+Q+ R QQL+ QL+ + R E+ E+ RL RE E +WL
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE---RRDWLKRE 461
Query: 182 EQLESGEEELVLAEYESDEEKK 203
E+ E E+E + + D+E++
Sbjct: 462 EETERHEQERRKQQLKRDQEEE 483
Score = 33.9 bits (76), Expect = 0.16
Identities = 34/144 (23%), Positives = 61/144 (42%), Gaps = 2/144 (1%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 119
E+++++EE R + + +++ L R E Q +++EE
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEER 372
Query: 120 LVNRLKVEQA-RRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEA 178
+L+ EQ RR+Q+ R QQL+ QL+ + R+++ E LR + L E
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR-REQQLRREQEE 431
Query: 179 EWLEQLESGEEELVLAEYESDEEK 202
E EQ E + E +E +
Sbjct: 432 ERHEQKHEQERREQRLKREQEERR 455
Score = 33.9 bits (76), Expect = 0.16
Identities = 41/169 (24%), Positives = 74/169 (43%), Gaps = 28/169 (16%)
Query: 53 LSWLRDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFV 112
L +L + EQ +R E A+ L+ L ++++ + R + W +
Sbjct: 831 LQFLEEEEQLQRRERAQQLQEEEDGLQEDQERR---------RSQEQRRDQKWRWQLEEE 881
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEE-----------ET 161
+K+ L + +++ RK+ ++ LQ+ + +Q + KR RQE+E E
Sbjct: 882 RKRRRHTLYAKPALQEQLRKE-QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEE 940
Query: 162 ENLLRLSRE---MLETGPEAEWLEQLESGEEELVLAEYE----SDEEKK 203
E LLR RE E + ++L+ EE+L+ E E + EKK
Sbjct: 941 EQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK 989
Score = 33.5 bits (75), Expect = 0.22
Identities = 40/134 (29%), Positives = 62/134 (46%), Gaps = 18/134 (13%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 119
++ KRE+E RL + L E+ E L E P E +++EER
Sbjct: 588 QRLKREQEERLEQR----LKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERR 643
Query: 120 LVNRLKVEQARRKQR------EERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLE 173
+ +Q RR+QR EERL+Q +LK + R+E+E E +RE ++
Sbjct: 644 QQQLRREQQERREQRLKREEEEERLEQ-----RLKREHEEERREQELAEEEQEQARERIK 698
Query: 174 TG-PEAEWLEQLES 186
+ P+ +W QLES
Sbjct: 699 SRIPKWQW--QLES 710
Score = 33.1 bits (74), Expect = 0.28
Identities = 24/90 (26%), Positives = 43/90 (47%), Gaps = 2/90 (2%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREML 172
+++E RD + R E+ R ++E R QQL+ + + + L+ EEEE + L
Sbjct: 450 EQEERRDWLKR--EEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL 507
Query: 173 ETGPEAEWLEQLESGEEELVLAEYESDEEK 202
E ++L+ EEE L + E++
Sbjct: 508 RREQEERREQRLKRQEEEERLQQRLRSEQQ 537
Score = 33.1 bits (74), Expect = 0.28
Identities = 26/107 (24%), Positives = 49/107 (45%), Gaps = 4/107 (3%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 119
++ KREEE LE H+E+ L+ + A + P W Q + + R
Sbjct: 657 QRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQ 716
Query: 120 LV----NRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETE 162
R + Q RR+++EE+ ++ + +Q + + RQ++EE +
Sbjct: 717 SKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQ 763
Score = 32.3 bits (72), Expect = 0.48
Identities = 25/100 (25%), Positives = 53/100 (53%), Gaps = 9/100 (9%)
Query: 110 QFVQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSR 169
Q ++++++ +L+ EQ R+++EE + +H + + +RL++E+EE + L+
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR--EQRLKREQEERRDWLKREE 462
Query: 170 EMLETGPEAEWLEQLESGEEE------LVLAEYESDEEKK 203
E E + +QL+ +EE L L E E E+++
Sbjct: 463 E-TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQE 501
Score = 32.3 bits (72), Expect = 0.48
Identities = 25/78 (32%), Positives = 43/78 (55%), Gaps = 7/78 (8%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQ-----HRVQLKYAAKRLRQEEEETENLLRL 167
Q++E+R L + EQ RR+QR ER ++LQ ++Q + A++L++EE+ +
Sbjct: 804 QQREQRFLPEEEEKEQ-RRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER 862
Query: 168 SREMLETGPEAEWLEQLE 185
R E + +W QLE
Sbjct: 863 RRSQ-EQRRDQKWRWQLE 879
Score = 32.3 bits (72), Expect = 0.48
Identities = 34/153 (22%), Positives = 68/153 (44%), Gaps = 12/153 (7%)
Query: 57 RDFEQKKREEEARLLETGTGPLHDEKDESLC----LSSSCEGAAGT-PRPAGEPAWVTQF 111
R+ EQ ++EEE L E E++ L E G P ++
Sbjct: 931 REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990
Query: 112 VQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREM 171
+++E + +L E+ +++R+E +Q + + +L+ ++L +EE E L R+
Sbjct: 991 REEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY 1050
Query: 172 LETGPEAEWLEQLESGEEELVLAEYESDEEKKV 204
E E+L+ EE+L+ E E+ +++
Sbjct: 1051 REE-------EELQQEEEQLLGEERETRRRQEL 1076
Score = 32.0 bits (71), Expect = 0.63
Identities = 17/60 (28%), Positives = 36/60 (60%), Gaps = 4/60 (6%)
Query: 115 KEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEE----ETENLLRLSRE 170
++ERD RL+ ++ RR+++E + + + +++ + ++LRQE + E E LL+ E
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE 1633
Score = 32.0 bits (71), Expect = 0.63
Identities = 20/65 (30%), Positives = 36/65 (55%), Gaps = 4/65 (6%)
Query: 110 QFVQKKEERDLV----NRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLL 165
Q +Q++EE+ L +R +E+ + +R+ER QQL+H K+ + +E E + L
Sbjct: 1626 QLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLR 1685
Query: 166 RLSRE 170
R R+
Sbjct: 1686 RQERD 1690
Score = 31.2 bits (69), Expect = 1.1
Identities = 22/85 (25%), Positives = 44/85 (51%), Gaps = 3/85 (3%)
Query: 115 KEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE--TENLLRLSREML 172
+EE L+ + +Q RR++R+ + ++ + +++ + ++ QEE++ + L R RE
Sbjct: 1670 REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEE 1729
Query: 173 ETGPEAEWLEQLESGEEELVLAEYE 197
+ E E EQL E + E E
Sbjct: 1730 QLRQETE-QEQLRRQERYRKILEEE 1753
Score = 30.8 bits (68), Expect = 1.4
Identities = 27/101 (26%), Positives = 46/101 (45%), Gaps = 13/101 (12%)
Query: 114 KKEERDLVNRLKVEQARRKQREERLQQLQHRVQ--------LKYAAKRLRQEEEETENLL 165
K+E+ + + LK E+ + +ER +Q R Q LK + R+++E E L
Sbjct: 448 KREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL 507
Query: 166 RLSRE-----MLETGPEAEWLEQLESGEEELVLAEYESDEE 201
R +E L+ E E L+Q E++L + E E+
Sbjct: 508 RREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Score = 29.6 bits (65), Expect = 3.1
Identities = 23/91 (25%), Positives = 48/91 (52%), Gaps = 2/91 (2%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREML 172
Q++E +D V + + E+ RK RE L++ + ++Q + ++ +EEE E L +L R+ L
Sbjct: 229 QRRERQDRVFQEEEEKEWRK-RETVLRKEEEKLQEEEPQRQRELQEEE-EQLRKLERQEL 286
Query: 173 ETGPEAEWLEQLESGEEELVLAEYESDEEKK 203
+ E +Q E+ + + E + ++
Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERREQ 317
Score = 29.6 bits (65), Expect = 3.1
Identities = 32/97 (32%), Positives = 43/97 (44%), Gaps = 13/97 (13%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERL--QQLQHRVQLKYAAKRLRQEEEETENLLRLSRE 170
++K ER RL R+QRE +L ++ Q R Q R EEEE E R RE
Sbjct: 774 EEKSERGR-QRLSARPPLREQRERQLRAEERQQREQ------RFLPEEEEKEQRRRQRRE 826
Query: 171 MLETGPEAEWLEQLESGEEELVLAEYE----SDEEKK 203
+ E EQL+ E L E E D+E++
Sbjct: 827 REKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERR 863
Score = 29.6 bits (65), Expect = 3.1
Identities = 38/159 (23%), Positives = 65/159 (40%), Gaps = 24/159 (15%)
Query: 57 RDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKE 116
++ E+K REEE ET L ++ L RP E + +++
Sbjct: 1719 QELERKFREEEQLRQETEQEQLRRQERYRKILEEE------QLRPEREEQQL-----RRQ 1767
Query: 117 ERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEE-------TENLLRLSR 169
ERD + + E+ R++REE+ + Q + ++LRQE EE + R
Sbjct: 1768 ERD--RKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEE 1825
Query: 170 EMLETGPEAEWLEQLES----GEEELVLAEYESDEEKKV 204
E L+ + + L Q EE+ E EE+++
Sbjct: 1826 EQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQEL 1864
Score = 29.6 bits (65), Expect = 3.1
Identities = 22/89 (24%), Positives = 44/89 (49%), Gaps = 14/89 (15%)
Query: 115 KEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLET 174
+EE L + +Q R +QR+ + + + ++QL+ +RLRQE + +
Sbjct: 1798 REEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDR------------QY 1845
Query: 175 GPEAEWLEQLESGEEELVLAEYESDEEKK 203
E ++ Q +S EE L ++ +E+K+
Sbjct: 1846 RAEEQFATQEKSRREEQEL--WQEEEQKR 1872
Score = 28.9 bits (63), Expect = 5.3
Identities = 23/84 (27%), Positives = 39/84 (46%), Gaps = 8/84 (9%)
Query: 127 EQARRKQREERLQQLQHRVQLKYAAKR--------LRQEEEETENLLRLSREMLETGPEA 178
+Q RR+Q EER +Q + + + KR L++EEE + ++ L+ E
Sbjct: 423 QQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEE 482
Query: 179 EWLEQLESGEEELVLAEYESDEEK 202
E E+ EEE + E E++
Sbjct: 483 ERRERWLKLEEEERREQQERREQQ 506
Score = 28.1 bits (61), Expect = 9.0
Identities = 26/95 (27%), Positives = 45/95 (47%), Gaps = 9/95 (9%)
Query: 110 QFVQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSR 169
Q +Q++EE+ L + ++ RK REE L+ + + +RLR++E E + L
Sbjct: 1343 QLLQEREEQPL----RRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFL--KEE 1396
Query: 170 EMLETGPEAEWLEQ---LESGEEELVLAEYESDEE 201
+ L + L Q + EEE L+ E D +
Sbjct: 1397 QQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431
Score = 28.1 bits (61), Expect = 9.0
Identities = 21/96 (21%), Positives = 45/96 (46%), Gaps = 7/96 (7%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEE----EETENLLRLS 168
Q +++RD R + +Q R++R+ + ++ + +V+ + ++ +EE +E R
Sbjct: 1407 QLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE 1466
Query: 169 REMLETGPEAEWLEQLESG---EEELVLAEYESDEE 201
++L+ E + Q EEE L E D +
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRK 1502
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 45.8 bits (107), Expect = 4e-05
Identities = 47/173 (27%), Positives = 81/173 (46%), Gaps = 10/173 (5%)
Query: 61 QKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDL 120
++K+EEEAR L + + + L E + A Q Q++ E++
Sbjct: 638 RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 697
Query: 121 VNRLKVEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEE--ETENLLRLSREMLETGPE 177
+ + EQ RR+Q R E+ +QL + + + +RL+ E E E E LRL +E L+
Sbjct: 698 REQERREQERREQERREQERQLAEQ-ERRREQERLQAERELQEREKALRLQKEQLQ---- 752
Query: 178 AEWLEQLESGEEELVLAEYE-SDEEKKVASGAPSDATSSRHPPDASFPAALNF 229
LE+ + EE+ LAE + +E++K A A + + D PA ++
Sbjct: 753 -RELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSY 804
Score = 36.2 bits (82), Expect = 0.033
Identities = 35/152 (23%), Positives = 63/152 (41%), Gaps = 11/152 (7%)
Query: 57 RDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKE 116
+ EQK + + + + L +EK + + E + E + Q++E
Sbjct: 597 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 656
Query: 117 ERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAA-----KRLRQEEEETENLLRLSREM 171
ER + ++ +K++EE ++L+ + K A +R QE E E + RE
Sbjct: 657 ER------RHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ 710
Query: 172 LETGPEAEWLEQLESGEEELVLAEYESDEEKK 203
E + EQ E+E + AE E E +K
Sbjct: 711 ERREQERQLAEQERRREQERLQAERELQEREK 742
Score = 33.1 bits (74), Expect = 0.28
Identities = 32/113 (28%), Positives = 58/113 (51%), Gaps = 21/113 (18%)
Query: 112 VQKKEERDLVNRLKVEQARRK-------QREERLQ---QLQHRVQ------LKYAAKRLR 155
+++KEE + + R KVE+ +R+ +REERL+ Q + RV+ K ++
Sbjct: 545 LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFA 604
Query: 156 QEEEETENLL--RLSREMLETGPEAEWLEQLES---GEEELVLAEYESDEEKK 203
Q +E+TE RL+ E + A+ +E++E+ EEE + EE++
Sbjct: 605 QIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEE 657
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 45.8 bits (107), Expect = 4e-05
Identities = 47/173 (27%), Positives = 81/173 (46%), Gaps = 10/173 (5%)
Query: 61 QKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDL 120
++K+EEEAR L + + + L E + A Q Q++ E++
Sbjct: 634 RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 693
Query: 121 VNRLKVEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEE--ETENLLRLSREMLETGPE 177
+ + EQ RR+Q R E+ +QL + + + +RL+ E E E E LRL +E L+
Sbjct: 694 REQERREQERREQERREQERQLAEQ-ERRREQERLQAERELQEREKALRLQKEQLQ---- 748
Query: 178 AEWLEQLESGEEELVLAEYE-SDEEKKVASGAPSDATSSRHPPDASFPAALNF 229
LE+ + EE+ LAE + +E++K A A + + D PA ++
Sbjct: 749 -RELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSY 800
Score = 36.2 bits (82), Expect = 0.033
Identities = 35/152 (23%), Positives = 63/152 (41%), Gaps = 11/152 (7%)
Query: 57 RDFEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKE 116
+ EQK + + + + L +EK + + E + E + Q++E
Sbjct: 593 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 652
Query: 117 ERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAA-----KRLRQEEEETENLLRLSREM 171
ER + ++ +K++EE ++L+ + K A +R QE E E + RE
Sbjct: 653 ER------RHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ 706
Query: 172 LETGPEAEWLEQLESGEEELVLAEYESDEEKK 203
E + EQ E+E + AE E E +K
Sbjct: 707 ERREQERQLAEQERRREQERLQAERELQEREK 738
Score = 33.1 bits (74), Expect = 0.28
Identities = 32/113 (28%), Positives = 58/113 (51%), Gaps = 21/113 (18%)
Query: 112 VQKKEERDLVNRLKVEQARRK-------QREERLQ---QLQHRVQ------LKYAAKRLR 155
+++KEE + + R KVE+ +R+ +REERL+ Q + RV+ K ++
Sbjct: 541 LRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFA 600
Query: 156 QEEEETENLL--RLSREMLETGPEAEWLEQLES---GEEELVLAEYESDEEKK 203
Q +E+TE RL+ E + A+ +E++E+ EEE + EE++
Sbjct: 601 QIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEE 653
>gi|22758136 MAP7 domain containing 2 [Homo sapiens]
Length = 732
Score = 43.5 bits (101), Expect = 2e-04
Identities = 46/176 (26%), Positives = 76/176 (43%), Gaps = 40/176 (22%)
Query: 60 EQKKREEEARLLETGTGPL------------HDEKDESLCLSSSCEGAAGTPRP------ 101
E+ +E E L + GP H + + E +A +P
Sbjct: 337 EKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTD 396
Query: 102 AGEPAWVT------------QFVQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKY 149
AGE A + Q Q++ E++ +RL+ E+ +RK EERL +L+ + K
Sbjct: 397 AGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERL-RLEEEAR-KQ 454
Query: 150 AAKRLRQEEEETENLLRLSREMLETGPEAEWLEQLESGEEELVLAEYESDEEKKVA 205
+R RQEEE+ + + E + G EA+ EEEL+L E + E+++ A
Sbjct: 455 EEERKRQEEEKKK---QEGEEKRKAGEEAK-----RKAEEELLLKEKQEQEKQEKA 502
Score = 34.3 bits (77), Expect = 0.13
Identities = 25/82 (30%), Positives = 42/82 (51%), Gaps = 4/82 (4%)
Query: 110 QFVQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAK-RLRQEEEETENLLRLS 168
Q ++K++ L ++E+ RK E+R ++ Q R ++ K +LR+EEE E ++R S
Sbjct: 75 QILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRS 134
Query: 169 RE---MLETGPEAEWLEQLESG 187
E LE + W L G
Sbjct: 135 LERTQQLELKKKYSWGAPLAIG 156
Score = 32.0 bits (71), Expect = 0.63
Identities = 38/149 (25%), Positives = 67/149 (44%), Gaps = 18/149 (12%)
Query: 73 TGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRLKVEQARRK 132
TG+ P + SL + GA T +P P + F++ E R ++ + RR+
Sbjct: 10 TGSRPEGTARGTSLPGKIAEPGAVRTSQPNYRPQGMEGFLKSDE------RQRLAKERRE 63
Query: 133 QREE----RLQQL---QHRVQLKYAAK-----RLRQEEEETENLLRLSREMLETGPEAEW 180
+RE+ R QQ+ Q R +L+Y + R +E+ + E+ R + E E
Sbjct: 64 EREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREE 123
Query: 181 LEQLESGEEELVLAEYESDEEKKVASGAP 209
E+LE+ + + + +KK + GAP
Sbjct: 124 EERLEAMMRRSLERTQQLELKKKYSWGAP 152
Score = 31.2 bits (69), Expect = 1.1
Identities = 26/103 (25%), Positives = 46/103 (44%), Gaps = 7/103 (6%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERL------QQLQHRVQLKYAAKRLRQEEEETENLLR 166
+KK++ R E+A+RK EE L Q+ Q + ++ + + E +R
Sbjct: 464 EKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMR 523
Query: 167 LSREMLETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGAP 209
L RE + E E LE+ + +E++ +SD +V P
Sbjct: 524 LEREQIMLQIEQERLER-KKRIDEIMKRTRKSDVPPQVKKEDP 565
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 41.6 bits (96), Expect = 8e-04
Identities = 28/95 (29%), Positives = 55/95 (57%), Gaps = 5/95 (5%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEE--ETENLLRLSRE 170
QK+ E R ++E+ +R+++E L++ Q R Q ++ +++R+EEE E+ R+
Sbjct: 392 QKRIEEQKEQRRRLEEQQRREKE--LRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRK 449
Query: 171 MLETGPEAEWLE-QLESGEEELVLAEYESDEEKKV 204
LE +AE L+ QL+ + LV +++ E++ V
Sbjct: 450 QLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPV 484
Score = 30.8 bits (68), Expect = 1.4
Identities = 38/139 (27%), Positives = 63/139 (45%), Gaps = 20/139 (14%)
Query: 81 EKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEER------DLVNRLKVEQARRKQR 134
EKDE+ S E +GEP+ + + R L N+ + E RR+Q
Sbjct: 315 EKDETEYEYSGSEEEE-EENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQL 373
Query: 135 EERLQQ-LQHRVQLKYAAKRLRQEEEETENLLRLS---------REMLETGPEAEWLEQL 184
E++ ++ +H+ QL A+R ++ EE+ E RL R+ E + EQ+
Sbjct: 374 EQQQRENEEHKRQL--LAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQM 431
Query: 185 ESGEEELVLAEYESDEEKK 203
EEE AE+E + ++K
Sbjct: 432 RR-EEERRRAEHEQEYKRK 449
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 41.6 bits (96), Expect = 8e-04
Identities = 28/95 (29%), Positives = 55/95 (57%), Gaps = 5/95 (5%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEE--ETENLLRLSRE 170
QK+ E R ++E+ +R+++E L++ Q R Q ++ +++R+EEE E+ R+
Sbjct: 392 QKRIEEQKEQRRRLEEQQRREKE--LRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRK 449
Query: 171 MLETGPEAEWLE-QLESGEEELVLAEYESDEEKKV 204
LE +AE L+ QL+ + LV +++ E++ V
Sbjct: 450 QLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPV 484
Score = 30.8 bits (68), Expect = 1.4
Identities = 38/139 (27%), Positives = 63/139 (45%), Gaps = 20/139 (14%)
Query: 81 EKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEER------DLVNRLKVEQARRKQR 134
EKDE+ S E +GEP+ + + R L N+ + E RR+Q
Sbjct: 315 EKDETEYEYSGSEEEE-EENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQL 373
Query: 135 EERLQQ-LQHRVQLKYAAKRLRQEEEETENLLRLS---------REMLETGPEAEWLEQL 184
E++ ++ +H+ QL A+R ++ EE+ E RL R+ E + EQ+
Sbjct: 374 EQQQRENEEHKRQL--LAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQM 431
Query: 185 ESGEEELVLAEYESDEEKK 203
EEE AE+E + ++K
Sbjct: 432 RR-EEERRRAEHEQEYKRK 449
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 41.6 bits (96), Expect = 8e-04
Identities = 28/95 (29%), Positives = 55/95 (57%), Gaps = 5/95 (5%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEE--ETENLLRLSRE 170
QK+ E R ++E+ +R+++E L++ Q R Q ++ +++R+EEE E+ R+
Sbjct: 392 QKRIEEQKEQRRRLEEQQRREKE--LRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRK 449
Query: 171 MLETGPEAEWLE-QLESGEEELVLAEYESDEEKKV 204
LE +AE L+ QL+ + LV +++ E++ V
Sbjct: 450 QLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPV 484
Score = 30.8 bits (68), Expect = 1.4
Identities = 38/139 (27%), Positives = 63/139 (45%), Gaps = 20/139 (14%)
Query: 81 EKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEER------DLVNRLKVEQARRKQR 134
EKDE+ S E +GEP+ + + R L N+ + E RR+Q
Sbjct: 315 EKDETEYEYSGSEEEE-EENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQL 373
Query: 135 EERLQQ-LQHRVQLKYAAKRLRQEEEETENLLRLS---------REMLETGPEAEWLEQL 184
E++ ++ +H+ QL A+R ++ EE+ E RL R+ E + EQ+
Sbjct: 374 EQQQRENEEHKRQL--LAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQM 431
Query: 185 ESGEEELVLAEYESDEEKK 203
EEE AE+E + ++K
Sbjct: 432 RR-EEERRRAEHEQEYKRK 449
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 41.6 bits (96), Expect = 8e-04
Identities = 28/95 (29%), Positives = 55/95 (57%), Gaps = 5/95 (5%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEE--ETENLLRLSRE 170
QK+ E R ++E+ +R+++E L++ Q R Q ++ +++R+EEE E+ R+
Sbjct: 392 QKRIEEQKEQRRRLEEQQRREKE--LRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRK 449
Query: 171 MLETGPEAEWLE-QLESGEEELVLAEYESDEEKKV 204
LE +AE L+ QL+ + LV +++ E++ V
Sbjct: 450 QLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPV 484
Score = 30.8 bits (68), Expect = 1.4
Identities = 38/139 (27%), Positives = 63/139 (45%), Gaps = 20/139 (14%)
Query: 81 EKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEER------DLVNRLKVEQARRKQR 134
EKDE+ S E +GEP+ + + R L N+ + E RR+Q
Sbjct: 315 EKDETEYEYSGSEEEE-EENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQL 373
Query: 135 EERLQQ-LQHRVQLKYAAKRLRQEEEETENLLRLS---------REMLETGPEAEWLEQL 184
E++ ++ +H+ QL A+R ++ EE+ E RL R+ E + EQ+
Sbjct: 374 EQQQRENEEHKRQL--LAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQM 431
Query: 185 ESGEEELVLAEYESDEEKK 203
EEE AE+E + ++K
Sbjct: 432 RR-EEERRRAEHEQEYKRK 449
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 41.6 bits (96), Expect = 8e-04
Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 12/149 (8%)
Query: 65 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 118
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510
Query: 119 -----DLVNRLKVEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEETENLLRLSREML 172
+L +R+K E ++++ LQ L+ R+Q + A +RLRQ E E ++++ E
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570
Query: 173 ETGPEAEWLEQLESGEEELVLAEYESDEE 201
+ EAE + S E+ E EE
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEE 1599
Score = 34.7 bits (78), Expect = 0.097
Identities = 43/155 (27%), Positives = 64/155 (41%), Gaps = 17/155 (10%)
Query: 114 KKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREML- 172
K EE+ + R EQ KQR+ Q R+ + RLR E E+ E +L E L
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737
Query: 173 ----ETGPEAEWLEQLES------GEEELVLAEYESDEEKKVASGAPS----DATSSRHP 218
E + ++LE+ E E++LA EE+ ++ S +A + R
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797
Query: 219 PDASFPAALNFL--QRTRPSSVLSEDLLMQRAVAK 251
A A L L + R + ED QRA A+
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832
Score = 33.1 bits (74), Expect = 0.28
Identities = 37/152 (24%), Positives = 67/152 (44%), Gaps = 12/152 (7%)
Query: 66 EEARL-LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRL 124
EEAR+ E + +E+ L S E A A A + ++K+ E++ R
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRA 2150
Query: 125 KVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEWLEQL 184
+ EQA +Q++ +++ K+A + LRQ+ + + L L ++ ET + L
Sbjct: 2151 QAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL--- 2205
Query: 185 ESGEEELVLAEYESDEEKKVASGAPSDATSSR 216
+EEL + E+ E + S + S R
Sbjct: 2206 ---DEELQRLKAEATEAARQRSQVEEELFSVR 2234
Score = 32.7 bits (73), Expect = 0.37
Identities = 40/155 (25%), Positives = 65/155 (41%), Gaps = 24/155 (15%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 119
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1352 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1400
Query: 120 LVNRLKVE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEETENLLR 166
+V R + Q +++ +E LQQL+ + + AK RLR EEE L+
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 167 LSREMLETGPEAEWLEQLESGEEELVLAEYESDEE 201
L + G L+ L + EE + ++ EE
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1495
Score = 32.0 bits (71), Expect = 0.63
Identities = 32/161 (19%), Positives = 72/161 (44%), Gaps = 3/161 (1%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQE-EEETENLLRLSREM 171
+++ E + L E+ +QR+ L++++ A+RLR+ E+E+ L+L++E
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042
Query: 172 LETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQ 231
+ +AE + +++ + +E+ V +A ++R + + A + +
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2102
Query: 232 RTRPS--SVLSEDLLMQRAVAKHPALLPSQMSSSPLRPGSE 270
S V + L Q A + A +Q ++ LR +E
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2143
Score = 31.6 bits (70), Expect = 0.82
Identities = 43/193 (22%), Positives = 79/193 (40%), Gaps = 4/193 (2%)
Query: 62 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 121
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316
Query: 122 NRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEWL 181
++ E R K E LQQ + Q + A+RL++++E+ L + + EAE
Sbjct: 2317 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 182 EQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQRTRPSSVLSE 241
QLE E L + E + + A DA R + T+ L +
Sbjct: 2374 RQLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432
Query: 242 DLLMQRAVAKHPA 254
L +QR + H A
Sbjct: 2433 TLEIQRQQSDHDA 2445
Score = 31.2 bits (69), Expect = 1.1
Identities = 36/108 (33%), Positives = 52/108 (48%), Gaps = 16/108 (14%)
Query: 115 KEERDLVNRLKVEQARRKQ--------REERLQQLQHRVQLKY-AAKRLRQEEEETENLL 165
+EE V +L+ E RR Q REE ++L+ R QLK A RLR + EE
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-RWQLKANEALRLRLQAEEVAQQK 1655
Query: 166 RLSREMLETGPEAEWLEQLESG--EEELV----LAEYESDEEKKVASG 207
L++ E E E G EE+ V LAE E ++++++A G
Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1703
Score = 30.8 bits (68), Expect = 1.4
Identities = 25/68 (36%), Positives = 37/68 (54%), Gaps = 5/68 (7%)
Query: 94 GAAGTPRPAGEPAWVTQFVQKKEERDLVNRLKVEQARR-KQREERLQQLQHRVQLKYAAK 152
G A R A E A + ++E +R +VE+A R KQ E +Q Q R Q + AA+
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQ--SRRQVEEAERLKQSAE--EQAQARAQAQAAAE 2136
Query: 153 RLRQEEEE 160
+LR+E E+
Sbjct: 2137 KLRKEAEQ 2144
Score = 30.8 bits (68), Expect = 1.4
Identities = 38/177 (21%), Positives = 75/177 (42%), Gaps = 19/177 (10%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 116
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2517
Query: 117 ERDLVNRLKVEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETG 175
+ K +Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2571
Query: 176 PEAEWLEQLESGEEELVLAEYES--------DEEKKVASGAPSDATSSRHPPDASFP 224
E + LEQ +EEL+ E + +E+ + A + T+S+ + P
Sbjct: 2572 -ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2627
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 41.6 bits (96), Expect = 8e-04
Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 12/149 (8%)
Query: 65 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 118
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1455 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1514
Query: 119 -----DLVNRLKVEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEETENLLRLSREML 172
+L +R+K E ++++ LQ L+ R+Q + A +RLRQ E E ++++ E
Sbjct: 1515 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1574
Query: 173 ETGPEAEWLEQLESGEEELVLAEYESDEE 201
+ EAE + S E+ E EE
Sbjct: 1575 QRSAEAELQSKRASFAEKTAQLERSLQEE 1603
Score = 34.7 bits (78), Expect = 0.097
Identities = 43/155 (27%), Positives = 64/155 (41%), Gaps = 17/155 (10%)
Query: 114 KKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREML- 172
K EE+ + R EQ KQR+ Q R+ + RLR E E+ E +L E L
Sbjct: 1682 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1741
Query: 173 ----ETGPEAEWLEQLES------GEEELVLAEYESDEEKKVASGAPS----DATSSRHP 218
E + ++LE+ E E++LA EE+ ++ S +A + R
Sbjct: 1742 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1801
Query: 219 PDASFPAALNFL--QRTRPSSVLSEDLLMQRAVAK 251
A A L L + R + ED QRA A+
Sbjct: 1802 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1836
Score = 33.1 bits (74), Expect = 0.28
Identities = 37/152 (24%), Positives = 67/152 (44%), Gaps = 12/152 (7%)
Query: 66 EEARL-LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRL 124
EEAR+ E + +E+ L S E A A A + ++K+ E++ R
Sbjct: 2098 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRA 2154
Query: 125 KVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEWLEQL 184
+ EQA +Q++ +++ K+A + LRQ+ + + L L ++ ET + L
Sbjct: 2155 QAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL--- 2209
Query: 185 ESGEEELVLAEYESDEEKKVASGAPSDATSSR 216
+EEL + E+ E + S + S R
Sbjct: 2210 ---DEELQRLKAEATEAARQRSQVEEELFSVR 2238
Score = 32.7 bits (73), Expect = 0.37
Identities = 40/155 (25%), Positives = 65/155 (41%), Gaps = 24/155 (15%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 119
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1356 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1404
Query: 120 LVNRLKVE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEETENLLR 166
+V R + Q +++ +E LQQL+ + + AK RLR EEE L+
Sbjct: 1405 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1464
Query: 167 LSREMLETGPEAEWLEQLESGEEELVLAEYESDEE 201
L + G L+ L + EE + ++ EE
Sbjct: 1465 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1499
Score = 32.0 bits (71), Expect = 0.63
Identities = 32/161 (19%), Positives = 72/161 (44%), Gaps = 3/161 (1%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQE-EEETENLLRLSREM 171
+++ E + L E+ +QR+ L++++ A+RLR+ E+E+ L+L++E
Sbjct: 1987 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2046
Query: 172 LETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQ 231
+ +AE + +++ + +E+ V +A ++R + + A + +
Sbjct: 2047 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2106
Query: 232 RTRPS--SVLSEDLLMQRAVAKHPALLPSQMSSSPLRPGSE 270
S V + L Q A + A +Q ++ LR +E
Sbjct: 2107 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2147
Score = 31.6 bits (70), Expect = 0.82
Identities = 43/193 (22%), Positives = 79/193 (40%), Gaps = 4/193 (2%)
Query: 62 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 121
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2261 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2320
Query: 122 NRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEWL 181
++ E R K E LQQ + Q + A+RL++++E+ L + + EAE
Sbjct: 2321 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377
Query: 182 EQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQRTRPSSVLSE 241
QLE E L + E + + A DA R + T+ L +
Sbjct: 2378 RQLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2436
Query: 242 DLLMQRAVAKHPA 254
L +QR + H A
Sbjct: 2437 TLEIQRQQSDHDA 2449
Score = 31.2 bits (69), Expect = 1.1
Identities = 36/108 (33%), Positives = 52/108 (48%), Gaps = 16/108 (14%)
Query: 115 KEERDLVNRLKVEQARRKQ--------REERLQQLQHRVQLKY-AAKRLRQEEEETENLL 165
+EE V +L+ E RR Q REE ++L+ R QLK A RLR + EE
Sbjct: 1601 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-RWQLKANEALRLRLQAEEVAQQK 1659
Query: 166 RLSREMLETGPEAEWLEQLESG--EEELV----LAEYESDEEKKVASG 207
L++ E E E G EE+ V LAE E ++++++A G
Sbjct: 1660 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1707
Score = 30.8 bits (68), Expect = 1.4
Identities = 25/68 (36%), Positives = 37/68 (54%), Gaps = 5/68 (7%)
Query: 94 GAAGTPRPAGEPAWVTQFVQKKEERDLVNRLKVEQARR-KQREERLQQLQHRVQLKYAAK 152
G A R A E A + ++E +R +VE+A R KQ E +Q Q R Q + AA+
Sbjct: 2085 GEAEAARRAAEEAEEARVQAEREAAQ--SRRQVEEAERLKQSAE--EQAQARAQAQAAAE 2140
Query: 153 RLRQEEEE 160
+LR+E E+
Sbjct: 2141 KLRKEAEQ 2148
Score = 30.8 bits (68), Expect = 1.4
Identities = 38/177 (21%), Positives = 75/177 (42%), Gaps = 19/177 (10%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 116
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2462 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2521
Query: 117 ERDLVNRLKVEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETG 175
+ K +Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2522 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2575
Query: 176 PEAEWLEQLESGEEELVLAEYES--------DEEKKVASGAPSDATSSRHPPDASFP 224
E + LEQ +EEL+ E + +E+ + A + T+S+ + P
Sbjct: 2576 -ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2631
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 41.6 bits (96), Expect = 8e-04
Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 12/149 (8%)
Query: 65 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 118
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510
Query: 119 -----DLVNRLKVEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEETENLLRLSREML 172
+L +R+K E ++++ LQ L+ R+Q + A +RLRQ E E ++++ E
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570
Query: 173 ETGPEAEWLEQLESGEEELVLAEYESDEE 201
+ EAE + S E+ E EE
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEE 1599
Score = 34.7 bits (78), Expect = 0.097
Identities = 43/155 (27%), Positives = 64/155 (41%), Gaps = 17/155 (10%)
Query: 114 KKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREML- 172
K EE+ + R EQ KQR+ Q R+ + RLR E E+ E +L E L
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737
Query: 173 ----ETGPEAEWLEQLES------GEEELVLAEYESDEEKKVASGAPS----DATSSRHP 218
E + ++LE+ E E++LA EE+ ++ S +A + R
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797
Query: 219 PDASFPAALNFL--QRTRPSSVLSEDLLMQRAVAK 251
A A L L + R + ED QRA A+
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832
Score = 33.1 bits (74), Expect = 0.28
Identities = 37/152 (24%), Positives = 67/152 (44%), Gaps = 12/152 (7%)
Query: 66 EEARL-LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRL 124
EEAR+ E + +E+ L S E A A A + ++K+ E++ R
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRA 2150
Query: 125 KVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEWLEQL 184
+ EQA +Q++ +++ K+A + LRQ+ + + L L ++ ET + L
Sbjct: 2151 QAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL--- 2205
Query: 185 ESGEEELVLAEYESDEEKKVASGAPSDATSSR 216
+EEL + E+ E + S + S R
Sbjct: 2206 ---DEELQRLKAEATEAARQRSQVEEELFSVR 2234
Score = 32.7 bits (73), Expect = 0.37
Identities = 40/155 (25%), Positives = 65/155 (41%), Gaps = 24/155 (15%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 119
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1352 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1400
Query: 120 LVNRLKVE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEETENLLR 166
+V R + Q +++ +E LQQL+ + + AK RLR EEE L+
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 167 LSREMLETGPEAEWLEQLESGEEELVLAEYESDEE 201
L + G L+ L + EE + ++ EE
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1495
Score = 32.0 bits (71), Expect = 0.63
Identities = 32/161 (19%), Positives = 72/161 (44%), Gaps = 3/161 (1%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQE-EEETENLLRLSREM 171
+++ E + L E+ +QR+ L++++ A+RLR+ E+E+ L+L++E
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042
Query: 172 LETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQ 231
+ +AE + +++ + +E+ V +A ++R + + A + +
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2102
Query: 232 RTRPS--SVLSEDLLMQRAVAKHPALLPSQMSSSPLRPGSE 270
S V + L Q A + A +Q ++ LR +E
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2143
Score = 31.6 bits (70), Expect = 0.82
Identities = 43/193 (22%), Positives = 79/193 (40%), Gaps = 4/193 (2%)
Query: 62 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 121
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316
Query: 122 NRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEWL 181
++ E R K E LQQ + Q + A+RL++++E+ L + + EAE
Sbjct: 2317 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 182 EQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQRTRPSSVLSE 241
QLE E L + E + + A DA R + T+ L +
Sbjct: 2374 RQLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432
Query: 242 DLLMQRAVAKHPA 254
L +QR + H A
Sbjct: 2433 TLEIQRQQSDHDA 2445
Score = 31.2 bits (69), Expect = 1.1
Identities = 36/108 (33%), Positives = 52/108 (48%), Gaps = 16/108 (14%)
Query: 115 KEERDLVNRLKVEQARRKQ--------REERLQQLQHRVQLKY-AAKRLRQEEEETENLL 165
+EE V +L+ E RR Q REE ++L+ R QLK A RLR + EE
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-RWQLKANEALRLRLQAEEVAQQK 1655
Query: 166 RLSREMLETGPEAEWLEQLESG--EEELV----LAEYESDEEKKVASG 207
L++ E E E G EE+ V LAE E ++++++A G
Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1703
Score = 30.8 bits (68), Expect = 1.4
Identities = 25/68 (36%), Positives = 37/68 (54%), Gaps = 5/68 (7%)
Query: 94 GAAGTPRPAGEPAWVTQFVQKKEERDLVNRLKVEQARR-KQREERLQQLQHRVQLKYAAK 152
G A R A E A + ++E +R +VE+A R KQ E +Q Q R Q + AA+
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQ--SRRQVEEAERLKQSAE--EQAQARAQAQAAAE 2136
Query: 153 RLRQEEEE 160
+LR+E E+
Sbjct: 2137 KLRKEAEQ 2144
Score = 30.8 bits (68), Expect = 1.4
Identities = 38/177 (21%), Positives = 75/177 (42%), Gaps = 19/177 (10%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 116
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2517
Query: 117 ERDLVNRLKVEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETG 175
+ K +Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2571
Query: 176 PEAEWLEQLESGEEELVLAEYES--------DEEKKVASGAPSDATSSRHPPDASFP 224
E + LEQ +EEL+ E + +E+ + A + T+S+ + P
Sbjct: 2572 -ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2627
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 41.6 bits (96), Expect = 8e-04
Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 12/149 (8%)
Query: 65 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 118
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1419 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1478
Query: 119 -----DLVNRLKVEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEETENLLRLSREML 172
+L +R+K E ++++ LQ L+ R+Q + A +RLRQ E E ++++ E
Sbjct: 1479 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1538
Query: 173 ETGPEAEWLEQLESGEEELVLAEYESDEE 201
+ EAE + S E+ E EE
Sbjct: 1539 QRSAEAELQSKRASFAEKTAQLERSLQEE 1567
Score = 34.7 bits (78), Expect = 0.097
Identities = 43/155 (27%), Positives = 64/155 (41%), Gaps = 17/155 (10%)
Query: 114 KKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREML- 172
K EE+ + R EQ KQR+ Q R+ + RLR E E+ E +L E L
Sbjct: 1646 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1705
Query: 173 ----ETGPEAEWLEQLES------GEEELVLAEYESDEEKKVASGAPS----DATSSRHP 218
E + ++LE+ E E++LA EE+ ++ S +A + R
Sbjct: 1706 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1765
Query: 219 PDASFPAALNFL--QRTRPSSVLSEDLLMQRAVAK 251
A A L L + R + ED QRA A+
Sbjct: 1766 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1800
Score = 33.1 bits (74), Expect = 0.28
Identities = 37/152 (24%), Positives = 67/152 (44%), Gaps = 12/152 (7%)
Query: 66 EEARL-LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRL 124
EEAR+ E + +E+ L S E A A A + ++K+ E++ R
Sbjct: 2062 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRA 2118
Query: 125 KVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEWLEQL 184
+ EQA +Q++ +++ K+A + LRQ+ + + L L ++ ET + L
Sbjct: 2119 QAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL--- 2173
Query: 185 ESGEEELVLAEYESDEEKKVASGAPSDATSSR 216
+EEL + E+ E + S + S R
Sbjct: 2174 ---DEELQRLKAEATEAARQRSQVEEELFSVR 2202
Score = 32.7 bits (73), Expect = 0.37
Identities = 40/155 (25%), Positives = 65/155 (41%), Gaps = 24/155 (15%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 119
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1320 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1368
Query: 120 LVNRLKVE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEETENLLR 166
+V R + Q +++ +E LQQL+ + + AK RLR EEE L+
Sbjct: 1369 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1428
Query: 167 LSREMLETGPEAEWLEQLESGEEELVLAEYESDEE 201
L + G L+ L + EE + ++ EE
Sbjct: 1429 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1463
Score = 32.0 bits (71), Expect = 0.63
Identities = 32/161 (19%), Positives = 72/161 (44%), Gaps = 3/161 (1%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQE-EEETENLLRLSREM 171
+++ E + L E+ +QR+ L++++ A+RLR+ E+E+ L+L++E
Sbjct: 1951 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2010
Query: 172 LETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQ 231
+ +AE + +++ + +E+ V +A ++R + + A + +
Sbjct: 2011 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2070
Query: 232 RTRPS--SVLSEDLLMQRAVAKHPALLPSQMSSSPLRPGSE 270
S V + L Q A + A +Q ++ LR +E
Sbjct: 2071 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2111
Score = 31.6 bits (70), Expect = 0.82
Identities = 43/193 (22%), Positives = 79/193 (40%), Gaps = 4/193 (2%)
Query: 62 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 121
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2225 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2284
Query: 122 NRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEWL 181
++ E R K E LQQ + Q + A+RL++++E+ L + + EAE
Sbjct: 2285 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341
Query: 182 EQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQRTRPSSVLSE 241
QLE E L + E + + A DA R + T+ L +
Sbjct: 2342 RQLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2400
Query: 242 DLLMQRAVAKHPA 254
L +QR + H A
Sbjct: 2401 TLEIQRQQSDHDA 2413
Score = 31.2 bits (69), Expect = 1.1
Identities = 36/108 (33%), Positives = 52/108 (48%), Gaps = 16/108 (14%)
Query: 115 KEERDLVNRLKVEQARRKQ--------REERLQQLQHRVQLKY-AAKRLRQEEEETENLL 165
+EE V +L+ E RR Q REE ++L+ R QLK A RLR + EE
Sbjct: 1565 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-RWQLKANEALRLRLQAEEVAQQK 1623
Query: 166 RLSREMLETGPEAEWLEQLESG--EEELV----LAEYESDEEKKVASG 207
L++ E E E G EE+ V LAE E ++++++A G
Sbjct: 1624 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1671
Score = 30.8 bits (68), Expect = 1.4
Identities = 25/68 (36%), Positives = 37/68 (54%), Gaps = 5/68 (7%)
Query: 94 GAAGTPRPAGEPAWVTQFVQKKEERDLVNRLKVEQARR-KQREERLQQLQHRVQLKYAAK 152
G A R A E A + ++E +R +VE+A R KQ E +Q Q R Q + AA+
Sbjct: 2049 GEAEAARRAAEEAEEARVQAEREAAQ--SRRQVEEAERLKQSAE--EQAQARAQAQAAAE 2104
Query: 153 RLRQEEEE 160
+LR+E E+
Sbjct: 2105 KLRKEAEQ 2112
Score = 30.8 bits (68), Expect = 1.4
Identities = 38/177 (21%), Positives = 75/177 (42%), Gaps = 19/177 (10%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 116
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2426 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2485
Query: 117 ERDLVNRLKVEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETG 175
+ K +Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2486 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2539
Query: 176 PEAEWLEQLESGEEELVLAEYES--------DEEKKVASGAPSDATSSRHPPDASFP 224
E + LEQ +EEL+ E + +E+ + A + T+S+ + P
Sbjct: 2540 -ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2595
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 41.6 bits (96), Expect = 8e-04
Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 12/149 (8%)
Query: 65 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 118
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1588 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1647
Query: 119 -----DLVNRLKVEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEETENLLRLSREML 172
+L +R+K E ++++ LQ L+ R+Q + A +RLRQ E E ++++ E
Sbjct: 1648 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1707
Query: 173 ETGPEAEWLEQLESGEEELVLAEYESDEE 201
+ EAE + S E+ E EE
Sbjct: 1708 QRSAEAELQSKRASFAEKTAQLERSLQEE 1736
Score = 34.7 bits (78), Expect = 0.097
Identities = 43/155 (27%), Positives = 64/155 (41%), Gaps = 17/155 (10%)
Query: 114 KKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREML- 172
K EE+ + R EQ KQR+ Q R+ + RLR E E+ E +L E L
Sbjct: 1815 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1874
Query: 173 ----ETGPEAEWLEQLES------GEEELVLAEYESDEEKKVASGAPS----DATSSRHP 218
E + ++LE+ E E++LA EE+ ++ S +A + R
Sbjct: 1875 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1934
Query: 219 PDASFPAALNFL--QRTRPSSVLSEDLLMQRAVAK 251
A A L L + R + ED QRA A+
Sbjct: 1935 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1969
Score = 33.1 bits (74), Expect = 0.28
Identities = 37/152 (24%), Positives = 67/152 (44%), Gaps = 12/152 (7%)
Query: 66 EEARL-LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRL 124
EEAR+ E + +E+ L S E A A A + ++K+ E++ R
Sbjct: 2231 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRA 2287
Query: 125 KVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEWLEQL 184
+ EQA +Q++ +++ K+A + LRQ+ + + L L ++ ET + L
Sbjct: 2288 QAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL--- 2342
Query: 185 ESGEEELVLAEYESDEEKKVASGAPSDATSSR 216
+EEL + E+ E + S + S R
Sbjct: 2343 ---DEELQRLKAEATEAARQRSQVEEELFSVR 2371
Score = 32.7 bits (73), Expect = 0.37
Identities = 40/155 (25%), Positives = 65/155 (41%), Gaps = 24/155 (15%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 119
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1489 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1537
Query: 120 LVNRLKVE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEETENLLR 166
+V R + Q +++ +E LQQL+ + + AK RLR EEE L+
Sbjct: 1538 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1597
Query: 167 LSREMLETGPEAEWLEQLESGEEELVLAEYESDEE 201
L + G L+ L + EE + ++ EE
Sbjct: 1598 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1632
Score = 32.0 bits (71), Expect = 0.63
Identities = 32/161 (19%), Positives = 72/161 (44%), Gaps = 3/161 (1%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQE-EEETENLLRLSREM 171
+++ E + L E+ +QR+ L++++ A+RLR+ E+E+ L+L++E
Sbjct: 2120 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2179
Query: 172 LETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQ 231
+ +AE + +++ + +E+ V +A ++R + + A + +
Sbjct: 2180 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2239
Query: 232 RTRPS--SVLSEDLLMQRAVAKHPALLPSQMSSSPLRPGSE 270
S V + L Q A + A +Q ++ LR +E
Sbjct: 2240 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2280
Score = 31.6 bits (70), Expect = 0.82
Identities = 43/193 (22%), Positives = 79/193 (40%), Gaps = 4/193 (2%)
Query: 62 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 121
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2394 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2453
Query: 122 NRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEWL 181
++ E R K E LQQ + Q + A+RL++++E+ L + + EAE
Sbjct: 2454 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510
Query: 182 EQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQRTRPSSVLSE 241
QLE E L + E + + A DA R + T+ L +
Sbjct: 2511 RQLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2569
Query: 242 DLLMQRAVAKHPA 254
L +QR + H A
Sbjct: 2570 TLEIQRQQSDHDA 2582
Score = 31.2 bits (69), Expect = 1.1
Identities = 36/108 (33%), Positives = 52/108 (48%), Gaps = 16/108 (14%)
Query: 115 KEERDLVNRLKVEQARRKQ--------REERLQQLQHRVQLKY-AAKRLRQEEEETENLL 165
+EE V +L+ E RR Q REE ++L+ R QLK A RLR + EE
Sbjct: 1734 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-RWQLKANEALRLRLQAEEVAQQK 1792
Query: 166 RLSREMLETGPEAEWLEQLESG--EEELV----LAEYESDEEKKVASG 207
L++ E E E G EE+ V LAE E ++++++A G
Sbjct: 1793 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1840
Score = 30.8 bits (68), Expect = 1.4
Identities = 25/68 (36%), Positives = 37/68 (54%), Gaps = 5/68 (7%)
Query: 94 GAAGTPRPAGEPAWVTQFVQKKEERDLVNRLKVEQARR-KQREERLQQLQHRVQLKYAAK 152
G A R A E A + ++E +R +VE+A R KQ E +Q Q R Q + AA+
Sbjct: 2218 GEAEAARRAAEEAEEARVQAEREAAQ--SRRQVEEAERLKQSAE--EQAQARAQAQAAAE 2273
Query: 153 RLRQEEEE 160
+LR+E E+
Sbjct: 2274 KLRKEAEQ 2281
Score = 30.8 bits (68), Expect = 1.4
Identities = 38/177 (21%), Positives = 75/177 (42%), Gaps = 19/177 (10%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 116
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2595 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2654
Query: 117 ERDLVNRLKVEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETG 175
+ K +Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2655 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2708
Query: 176 PEAEWLEQLESGEEELVLAEYES--------DEEKKVASGAPSDATSSRHPPDASFP 224
E + LEQ +EEL+ E + +E+ + A + T+S+ + P
Sbjct: 2709 -ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2764
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 41.6 bits (96), Expect = 8e-04
Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 12/149 (8%)
Query: 65 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 118
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1429 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1488
Query: 119 -----DLVNRLKVEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEETENLLRLSREML 172
+L +R+K E ++++ LQ L+ R+Q + A +RLRQ E E ++++ E
Sbjct: 1489 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1548
Query: 173 ETGPEAEWLEQLESGEEELVLAEYESDEE 201
+ EAE + S E+ E EE
Sbjct: 1549 QRSAEAELQSKRASFAEKTAQLERSLQEE 1577
Score = 34.7 bits (78), Expect = 0.097
Identities = 43/155 (27%), Positives = 64/155 (41%), Gaps = 17/155 (10%)
Query: 114 KKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREML- 172
K EE+ + R EQ KQR+ Q R+ + RLR E E+ E +L E L
Sbjct: 1656 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1715
Query: 173 ----ETGPEAEWLEQLES------GEEELVLAEYESDEEKKVASGAPS----DATSSRHP 218
E + ++LE+ E E++LA EE+ ++ S +A + R
Sbjct: 1716 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1775
Query: 219 PDASFPAALNFL--QRTRPSSVLSEDLLMQRAVAK 251
A A L L + R + ED QRA A+
Sbjct: 1776 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1810
Score = 33.1 bits (74), Expect = 0.28
Identities = 37/152 (24%), Positives = 67/152 (44%), Gaps = 12/152 (7%)
Query: 66 EEARL-LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRL 124
EEAR+ E + +E+ L S E A A A + ++K+ E++ R
Sbjct: 2072 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRA 2128
Query: 125 KVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEWLEQL 184
+ EQA +Q++ +++ K+A + LRQ+ + + L L ++ ET + L
Sbjct: 2129 QAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL--- 2183
Query: 185 ESGEEELVLAEYESDEEKKVASGAPSDATSSR 216
+EEL + E+ E + S + S R
Sbjct: 2184 ---DEELQRLKAEATEAARQRSQVEEELFSVR 2212
Score = 32.7 bits (73), Expect = 0.37
Identities = 40/155 (25%), Positives = 65/155 (41%), Gaps = 24/155 (15%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 119
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1330 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1378
Query: 120 LVNRLKVE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEETENLLR 166
+V R + Q +++ +E LQQL+ + + AK RLR EEE L+
Sbjct: 1379 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1438
Query: 167 LSREMLETGPEAEWLEQLESGEEELVLAEYESDEE 201
L + G L+ L + EE + ++ EE
Sbjct: 1439 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1473
Score = 32.0 bits (71), Expect = 0.63
Identities = 32/161 (19%), Positives = 72/161 (44%), Gaps = 3/161 (1%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQE-EEETENLLRLSREM 171
+++ E + L E+ +QR+ L++++ A+RLR+ E+E+ L+L++E
Sbjct: 1961 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2020
Query: 172 LETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQ 231
+ +AE + +++ + +E+ V +A ++R + + A + +
Sbjct: 2021 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2080
Query: 232 RTRPS--SVLSEDLLMQRAVAKHPALLPSQMSSSPLRPGSE 270
S V + L Q A + A +Q ++ LR +E
Sbjct: 2081 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2121
Score = 31.6 bits (70), Expect = 0.82
Identities = 43/193 (22%), Positives = 79/193 (40%), Gaps = 4/193 (2%)
Query: 62 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 121
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2235 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2294
Query: 122 NRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEWL 181
++ E R K E LQQ + Q + A+RL++++E+ L + + EAE
Sbjct: 2295 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351
Query: 182 EQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQRTRPSSVLSE 241
QLE E L + E + + A DA R + T+ L +
Sbjct: 2352 RQLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2410
Query: 242 DLLMQRAVAKHPA 254
L +QR + H A
Sbjct: 2411 TLEIQRQQSDHDA 2423
Score = 31.2 bits (69), Expect = 1.1
Identities = 36/108 (33%), Positives = 52/108 (48%), Gaps = 16/108 (14%)
Query: 115 KEERDLVNRLKVEQARRKQ--------REERLQQLQHRVQLKY-AAKRLRQEEEETENLL 165
+EE V +L+ E RR Q REE ++L+ R QLK A RLR + EE
Sbjct: 1575 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-RWQLKANEALRLRLQAEEVAQQK 1633
Query: 166 RLSREMLETGPEAEWLEQLESG--EEELV----LAEYESDEEKKVASG 207
L++ E E E G EE+ V LAE E ++++++A G
Sbjct: 1634 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1681
Score = 30.8 bits (68), Expect = 1.4
Identities = 25/68 (36%), Positives = 37/68 (54%), Gaps = 5/68 (7%)
Query: 94 GAAGTPRPAGEPAWVTQFVQKKEERDLVNRLKVEQARR-KQREERLQQLQHRVQLKYAAK 152
G A R A E A + ++E +R +VE+A R KQ E +Q Q R Q + AA+
Sbjct: 2059 GEAEAARRAAEEAEEARVQAEREAAQ--SRRQVEEAERLKQSAE--EQAQARAQAQAAAE 2114
Query: 153 RLRQEEEE 160
+LR+E E+
Sbjct: 2115 KLRKEAEQ 2122
Score = 30.8 bits (68), Expect = 1.4
Identities = 38/177 (21%), Positives = 75/177 (42%), Gaps = 19/177 (10%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 116
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2436 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2495
Query: 117 ERDLVNRLKVEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETG 175
+ K +Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2496 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2549
Query: 176 PEAEWLEQLESGEEELVLAEYES--------DEEKKVASGAPSDATSSRHPPDASFP 224
E + LEQ +EEL+ E + +E+ + A + T+S+ + P
Sbjct: 2550 -ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2605
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 41.6 bits (96), Expect = 8e-04
Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 12/149 (8%)
Query: 65 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 118
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1437 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1496
Query: 119 -----DLVNRLKVEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEETENLLRLSREML 172
+L +R+K E ++++ LQ L+ R+Q + A +RLRQ E E ++++ E
Sbjct: 1497 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1556
Query: 173 ETGPEAEWLEQLESGEEELVLAEYESDEE 201
+ EAE + S E+ E EE
Sbjct: 1557 QRSAEAELQSKRASFAEKTAQLERSLQEE 1585
Score = 34.7 bits (78), Expect = 0.097
Identities = 43/155 (27%), Positives = 64/155 (41%), Gaps = 17/155 (10%)
Query: 114 KKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREML- 172
K EE+ + R EQ KQR+ Q R+ + RLR E E+ E +L E L
Sbjct: 1664 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1723
Query: 173 ----ETGPEAEWLEQLES------GEEELVLAEYESDEEKKVASGAPS----DATSSRHP 218
E + ++LE+ E E++LA EE+ ++ S +A + R
Sbjct: 1724 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1783
Query: 219 PDASFPAALNFL--QRTRPSSVLSEDLLMQRAVAK 251
A A L L + R + ED QRA A+
Sbjct: 1784 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1818
Score = 33.1 bits (74), Expect = 0.28
Identities = 37/152 (24%), Positives = 67/152 (44%), Gaps = 12/152 (7%)
Query: 66 EEARL-LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRL 124
EEAR+ E + +E+ L S E A A A + ++K+ E++ R
Sbjct: 2080 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRA 2136
Query: 125 KVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEWLEQL 184
+ EQA +Q++ +++ K+A + LRQ+ + + L L ++ ET + L
Sbjct: 2137 QAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL--- 2191
Query: 185 ESGEEELVLAEYESDEEKKVASGAPSDATSSR 216
+EEL + E+ E + S + S R
Sbjct: 2192 ---DEELQRLKAEATEAARQRSQVEEELFSVR 2220
Score = 32.7 bits (73), Expect = 0.37
Identities = 40/155 (25%), Positives = 65/155 (41%), Gaps = 24/155 (15%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 119
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1338 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1386
Query: 120 LVNRLKVE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEETENLLR 166
+V R + Q +++ +E LQQL+ + + AK RLR EEE L+
Sbjct: 1387 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1446
Query: 167 LSREMLETGPEAEWLEQLESGEEELVLAEYESDEE 201
L + G L+ L + EE + ++ EE
Sbjct: 1447 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1481
Score = 32.0 bits (71), Expect = 0.63
Identities = 32/161 (19%), Positives = 72/161 (44%), Gaps = 3/161 (1%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQE-EEETENLLRLSREM 171
+++ E + L E+ +QR+ L++++ A+RLR+ E+E+ L+L++E
Sbjct: 1969 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2028
Query: 172 LETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQ 231
+ +AE + +++ + +E+ V +A ++R + + A + +
Sbjct: 2029 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2088
Query: 232 RTRPS--SVLSEDLLMQRAVAKHPALLPSQMSSSPLRPGSE 270
S V + L Q A + A +Q ++ LR +E
Sbjct: 2089 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2129
Score = 31.6 bits (70), Expect = 0.82
Identities = 43/193 (22%), Positives = 79/193 (40%), Gaps = 4/193 (2%)
Query: 62 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 121
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2243 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2302
Query: 122 NRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEWL 181
++ E R K E LQQ + Q + A+RL++++E+ L + + EAE
Sbjct: 2303 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2359
Query: 182 EQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQRTRPSSVLSE 241
QLE E L + E + + A DA R + T+ L +
Sbjct: 2360 RQLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2418
Query: 242 DLLMQRAVAKHPA 254
L +QR + H A
Sbjct: 2419 TLEIQRQQSDHDA 2431
Score = 31.2 bits (69), Expect = 1.1
Identities = 36/108 (33%), Positives = 52/108 (48%), Gaps = 16/108 (14%)
Query: 115 KEERDLVNRLKVEQARRKQ--------REERLQQLQHRVQLKY-AAKRLRQEEEETENLL 165
+EE V +L+ E RR Q REE ++L+ R QLK A RLR + EE
Sbjct: 1583 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-RWQLKANEALRLRLQAEEVAQQK 1641
Query: 166 RLSREMLETGPEAEWLEQLESG--EEELV----LAEYESDEEKKVASG 207
L++ E E E G EE+ V LAE E ++++++A G
Sbjct: 1642 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1689
Score = 30.8 bits (68), Expect = 1.4
Identities = 25/68 (36%), Positives = 37/68 (54%), Gaps = 5/68 (7%)
Query: 94 GAAGTPRPAGEPAWVTQFVQKKEERDLVNRLKVEQARR-KQREERLQQLQHRVQLKYAAK 152
G A R A E A + ++E +R +VE+A R KQ E +Q Q R Q + AA+
Sbjct: 2067 GEAEAARRAAEEAEEARVQAEREAAQ--SRRQVEEAERLKQSAE--EQAQARAQAQAAAE 2122
Query: 153 RLRQEEEE 160
+LR+E E+
Sbjct: 2123 KLRKEAEQ 2130
Score = 30.8 bits (68), Expect = 1.4
Identities = 38/177 (21%), Positives = 75/177 (42%), Gaps = 19/177 (10%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 116
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2444 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2503
Query: 117 ERDLVNRLKVEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETG 175
+ K +Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2504 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2557
Query: 176 PEAEWLEQLESGEEELVLAEYES--------DEEKKVASGAPSDATSSRHPPDASFP 224
E + LEQ +EEL+ E + +E+ + A + T+S+ + P
Sbjct: 2558 -ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2613
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 41.6 bits (96), Expect = 8e-04
Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 12/149 (8%)
Query: 65 EEEARL----LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAW-VTQFVQKKEER- 118
EEE R+ LE + E L + E A R A E A + + VQ + +R
Sbjct: 1478 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1537
Query: 119 -----DLVNRLKVEQARRKQREERLQQLQH-RVQLKYAAKRLRQEEEETENLLRLSREML 172
+L +R+K E ++++ LQ L+ R+Q + A +RLRQ E E ++++ E
Sbjct: 1538 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1597
Query: 173 ETGPEAEWLEQLESGEEELVLAEYESDEE 201
+ EAE + S E+ E EE
Sbjct: 1598 QRSAEAELQSKRASFAEKTAQLERSLQEE 1626
Score = 34.7 bits (78), Expect = 0.097
Identities = 43/155 (27%), Positives = 64/155 (41%), Gaps = 17/155 (10%)
Query: 114 KKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREML- 172
K EE+ + R EQ KQR+ Q R+ + RLR E E+ E +L E L
Sbjct: 1705 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1764
Query: 173 ----ETGPEAEWLEQLES------GEEELVLAEYESDEEKKVASGAPS----DATSSRHP 218
E + ++LE+ E E++LA EE+ ++ S +A + R
Sbjct: 1765 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1824
Query: 219 PDASFPAALNFL--QRTRPSSVLSEDLLMQRAVAK 251
A A L L + R + ED QRA A+
Sbjct: 1825 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1859
Score = 33.1 bits (74), Expect = 0.28
Identities = 37/152 (24%), Positives = 67/152 (44%), Gaps = 12/152 (7%)
Query: 66 EEARL-LETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRL 124
EEAR+ E + +E+ L S E A A A + ++K+ E++ R
Sbjct: 2121 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKLRKEAEQEAARRA 2177
Query: 125 KVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEWLEQL 184
+ EQA +Q++ +++ K+A + LRQ+ + + L L ++ ET + L
Sbjct: 2178 QAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLL--- 2232
Query: 185 ESGEEELVLAEYESDEEKKVASGAPSDATSSR 216
+EEL + E+ E + S + S R
Sbjct: 2233 ---DEELQRLKAEATEAARQRSQVEEELFSVR 2261
Score = 32.7 bits (73), Expect = 0.37
Identities = 40/155 (25%), Positives = 65/155 (41%), Gaps = 24/155 (15%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERD 119
EQ++ EE RL E EK L + + A R A E +Q++ + +
Sbjct: 1379 EQQRAEERERLAEVEAAL---EKQRQLA-EAHAQAKAQAEREAKE-------LQQRMQEE 1427
Query: 120 LVNRLKVE---QARRKQREERLQQLQHRVQLKYAAK----------RLRQEEEETENLLR 166
+V R + Q +++ +E LQQL+ + + AK RLR EEE L+
Sbjct: 1428 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1487
Query: 167 LSREMLETGPEAEWLEQLESGEEELVLAEYESDEE 201
L + G L+ L + EE + ++ EE
Sbjct: 1488 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1522
Score = 32.0 bits (71), Expect = 0.63
Identities = 32/161 (19%), Positives = 72/161 (44%), Gaps = 3/161 (1%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQE-EEETENLLRLSREM 171
+++ E + L E+ +QR+ L++++ A+RLR+ E+E+ L+L++E
Sbjct: 2010 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2069
Query: 172 LETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQ 231
+ +AE + +++ + +E+ V +A ++R + + A + +
Sbjct: 2070 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2129
Query: 232 RTRPS--SVLSEDLLMQRAVAKHPALLPSQMSSSPLRPGSE 270
S V + L Q A + A +Q ++ LR +E
Sbjct: 2130 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2170
Score = 31.6 bits (70), Expect = 0.82
Identities = 43/193 (22%), Positives = 79/193 (40%), Gaps = 4/193 (2%)
Query: 62 KKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLV 121
+ ++ R L+ + +E+ LS + + AA + A E + + +K ++ +
Sbjct: 2284 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2343
Query: 122 NRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEWL 181
++ E R K E LQQ + Q + A+RL++++E+ L + + EAE
Sbjct: 2344 QAVQ-EATRLKAEAELLQQQKELAQEQ--ARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400
Query: 182 EQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQRTRPSSVLSE 241
QLE E L + E + + A DA R + T+ L +
Sbjct: 2401 RQLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2459
Query: 242 DLLMQRAVAKHPA 254
L +QR + H A
Sbjct: 2460 TLEIQRQQSDHDA 2472
Score = 31.2 bits (69), Expect = 1.1
Identities = 36/108 (33%), Positives = 52/108 (48%), Gaps = 16/108 (14%)
Query: 115 KEERDLVNRLKVEQARRKQ--------REERLQQLQHRVQLKY-AAKRLRQEEEETENLL 165
+EE V +L+ E RR Q REE ++L+ R QLK A RLR + EE
Sbjct: 1624 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-RWQLKANEALRLRLQAEEVAQQK 1682
Query: 166 RLSREMLETGPEAEWLEQLESG--EEELV----LAEYESDEEKKVASG 207
L++ E E E G EE+ V LAE E ++++++A G
Sbjct: 1683 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1730
Score = 30.8 bits (68), Expect = 1.4
Identities = 25/68 (36%), Positives = 37/68 (54%), Gaps = 5/68 (7%)
Query: 94 GAAGTPRPAGEPAWVTQFVQKKEERDLVNRLKVEQARR-KQREERLQQLQHRVQLKYAAK 152
G A R A E A + ++E +R +VE+A R KQ E +Q Q R Q + AA+
Sbjct: 2108 GEAEAARRAAEEAEEARVQAEREAAQ--SRRQVEEAERLKQSAE--EQAQARAQAQAAAE 2163
Query: 153 RLRQEEEE 160
+LR+E E+
Sbjct: 2164 KLRKEAEQ 2171
Score = 30.8 bits (68), Expect = 1.4
Identities = 38/177 (21%), Positives = 75/177 (42%), Gaps = 19/177 (10%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAG---EPAWVTQFVQKKE 116
E++K ++EA+LL+ + + + E L + + ++ Q K E
Sbjct: 2485 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2544
Query: 117 ERDLVNRLKVEQARRKQ-REERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETG 175
+ K +Q R +Q R+++ Q Q R +L + + R+ + E E +R +E
Sbjct: 2545 QLFQDEVAKAQQLREEQQRQQQ-QMEQERQRLVASMEEARRRQHEAEEGVRRKQE----- 2598
Query: 176 PEAEWLEQLESGEEELVLAEYES--------DEEKKVASGAPSDATSSRHPPDASFP 224
E + LEQ +EEL+ E + +E+ + A + T+S+ + P
Sbjct: 2599 -ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2654
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 41.2 bits (95), Expect = 0.001
Identities = 32/128 (25%), Positives = 57/128 (44%), Gaps = 8/128 (6%)
Query: 124 LKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEAEWLEQ 183
++V+Q + + REE+ Q+ R L+ K+ E+E E + R E++E + E EQ
Sbjct: 300 IEVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIE--EQ 357
Query: 184 LESGEEEL---VLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQRTRPSSVLS 240
+ ++EL E ++E+K A R + + A LQ +R
Sbjct: 358 TKKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEA---LLQASRDQKKTQ 414
Query: 241 EDLLMQRA 248
E L ++ A
Sbjct: 415 EQLALEMA 422
Score = 31.2 bits (69), Expect = 1.1
Identities = 22/93 (23%), Positives = 44/93 (47%), Gaps = 5/93 (5%)
Query: 113 QKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSREML 172
QK+ ER ++ K ++ ++ +E++++ + + +RL+Q EE+T+ + E
Sbjct: 315 QKQMERAMLENEKKKREMAEKEKEKIEREKEELM-----ERLKQIEEQTKKAQQELEEQT 369
Query: 173 ETGPEAEWLEQLESGEEELVLAEYESDEEKKVA 205
E E + E E + E + EE K A
Sbjct: 370 RRALELEQERKRAQSEAEKLAKERQEAEEAKEA 402
>gi|92859701 myosin VI [Homo sapiens]
Length = 1285
Score = 41.2 bits (95), Expect = 0.001
Identities = 40/138 (28%), Positives = 64/138 (46%), Gaps = 24/138 (17%)
Query: 112 VQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEE-----------E 160
+Q++ E++ R + E+ RRK+ EER R++L+ AKR ++EEE +
Sbjct: 929 IQEEMEKERKRREEDEKRRRKEEEER------RMKLEMEAKRKQEEEERKKREDDEKRIQ 982
Query: 161 TENLLRLSREMLETGPEAEWLEQLESGEEELVL------AEYESDEEKKVASGAPSDATS 214
E +L+R+ E + LEQ E + EL L AE SDE + + +D T
Sbjct: 983 AEVEAQLARQKEEESQQQAVLEQ-ERRDRELALRIAQSEAELISDEAQADLALRRNDGTR 1041
Query: 215 SRHPPDASFPAALNFLQR 232
+ P+ FL R
Sbjct: 1042 PKMTPEQMAKEMSEFLSR 1059
Score = 37.4 bits (85), Expect = 0.015
Identities = 35/154 (22%), Positives = 66/154 (42%), Gaps = 14/154 (9%)
Query: 115 KEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEE-------EETENLLRL 167
K +L++ L+ ++KQ+EE ++L+ R+Q + +R R+EE EE E ++L
Sbjct: 904 KSSEELLSALQ----KKKQQEEEAERLR-RIQEEMEKERKRREEDEKRRRKEEEERRMKL 958
Query: 168 SREMLETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAAL 227
E E E + +E+ + AE E+ ++ + A + D +
Sbjct: 959 EMEAKRKQEEEE--RKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRI 1016
Query: 228 NFLQRTRPSSVLSEDLLMQRAVAKHPALLPSQMS 261
+ S DL ++R P + P QM+
Sbjct: 1017 AQSEAELISDEAQADLALRRNDGTRPKMTPEQMA 1050
Score = 30.0 bits (66), Expect = 2.4
Identities = 22/85 (25%), Positives = 42/85 (49%), Gaps = 1/85 (1%)
Query: 120 LVNRLKVEQARRKQREERLQQL-QHRVQLKYAAKRLRQEEEETENLLRLSREMLETGPEA 178
L+ ++K ++Q ++ L + +L A ++ +Q+EEE E L R+ EM +
Sbjct: 881 LMAKIKSTMMTQEQIQKEYDALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRR 940
Query: 179 EWLEQLESGEEELVLAEYESDEEKK 203
E E+ EEE + E + ++K
Sbjct: 941 EEDEKRRRKEEEERRMKLEMEAKRK 965
>gi|169208122 PREDICTED: hypothetical protein isoform 1 [Homo
sapiens]
Length = 479
Score = 40.8 bits (94), Expect = 0.001
Identities = 52/161 (32%), Positives = 79/161 (49%), Gaps = 26/161 (16%)
Query: 49 ICGALSWLRDFEQKKREEEARLLETGTGPLHD-----EKDESLCLSSSCEGAAGTPRPAG 103
+C LR+ E++ RE+E RL E E++E LC E G R
Sbjct: 229 LCEQEERLREQEERLREQEERLHEQEERLCEQEERLCEQEERLC---EQEKLPGQERLLE 285
Query: 104 EPAWVTQFVQKKEERD-LVNRLK--------VEQARRKQREERLQQLQHRVQLKYAAKRL 154
E + + +++EE++ L+ R + +EQ R +Q++ERL Q + +L +RL
Sbjct: 286 EVEKLLEQERRQEEQERLLERERLLDEVEELLEQERLRQQDERLWQQETLREL----ERL 341
Query: 155 RQEE--EETENLLRLSREMLETGPEAEWLEQLE--SGEEEL 191
R+ E E E L L R MLE G EA + ++ E SG EEL
Sbjct: 342 RELERLRELERLRELER-MLELGWEALYEQRAEPRSGFEEL 381
Score = 31.2 bits (69), Expect = 1.1
Identities = 42/142 (29%), Positives = 65/142 (45%), Gaps = 29/142 (20%)
Query: 60 EQKKREEEARLLETGTGPLHDEKDESLCLSSS--CEGAAGTPRPAGEPAWVTQFVQKKEE 117
E++ RE+E RL E LH E++E LC CE Q++
Sbjct: 198 EERLREQEERLHEQEER-LH-EQEERLCEQEERLCE-------------------QEERL 236
Query: 118 RDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEE--ETENLLRLSREMLETG 175
R+ RL+ ++ R ++EERL + + R L +RL ++E+ E LL ++LE
Sbjct: 237 REQEERLREQEERLHEQEERLCEQEER--LCEQEERLCEQEKLPGQERLLEEVEKLLEQE 294
Query: 176 PEAEWLEQLESGEEELVLAEYE 197
E E+L E E +L E E
Sbjct: 295 RRQEEQERLL--ERERLLDEVE 314
>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform
b [Homo sapiens]
Length = 1173
Score = 40.0 bits (92), Expect = 0.002
Identities = 38/129 (29%), Positives = 62/129 (48%), Gaps = 14/129 (10%)
Query: 111 FVQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLL-RLSR 169
F +++EER + +L+ + +QR ER +Q QH+ +L+ A RL++ E E L RL +
Sbjct: 858 FEKQREERAALEKLQSQLRHEQQRWERERQWQHQ-ELERAGARLQEREGEARQLRERLEQ 916
Query: 170 EMLETGPEAE-WLEQLESGEEELVLAEYESD--------EEKKVASGA-PSDATSSRHPP 219
E E + + + LE E E E + +++ A GA P D + PP
Sbjct: 917 ERAELERQRQAYQHDLERLREAQRAVERERERLELLRRLKKQNTAPGALPPDTLAEAQPP 976
Query: 220 DASFPAALN 228
S P + N
Sbjct: 977 --SHPPSFN 983
>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
[Homo sapiens]
Length = 1015
Score = 40.0 bits (92), Expect = 0.002
Identities = 38/129 (29%), Positives = 62/129 (48%), Gaps = 14/129 (10%)
Query: 111 FVQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLL-RLSR 169
F +++EER + +L+ + +QR ER +Q QH+ +L+ A RL++ E E L RL +
Sbjct: 700 FEKQREERAALEKLQSQLRHEQQRWERERQWQHQ-ELERAGARLQEREGEARQLRERLEQ 758
Query: 170 EMLETGPEAE-WLEQLESGEEELVLAEYESD--------EEKKVASGA-PSDATSSRHPP 219
E E + + + LE E E E + +++ A GA P D + PP
Sbjct: 759 ERAELERQRQAYQHDLERLREAQRAVERERERLELLRRLKKQNTAPGALPPDTLAEAQPP 818
Query: 220 DASFPAALN 228
S P + N
Sbjct: 819 --SHPPSFN 825
>gi|10863889 squamous cell carcinoma antigen recognized by T cells 1
[Homo sapiens]
Length = 800
Score = 40.0 bits (92), Expect = 0.002
Identities = 39/146 (26%), Positives = 69/146 (47%), Gaps = 19/146 (13%)
Query: 77 PLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRLKVEQARRKQREE 136
P D + E++ +S EG A P G P V +++E +L + ++E+ RR ++ +
Sbjct: 462 PSDDTRVENMDISDEEEGGAPPP---GSPQ-----VLEEDEAELELQKQLEKGRRLRQLQ 513
Query: 137 RLQQLQHRVQ-----LKYAAKRLR--QEEEETEN----LLRLSREMLETGPEAEWLEQLE 185
+LQQL+ + +K R R +E+E+ E + + E T E
Sbjct: 514 QLQQLRDSGEKVVEIVKKLESRQRGWEEDEDPERKGAIVFNATSEFCRTLGEIPTYGLAG 573
Query: 186 SGEEELVLAEYESDEEKKVASGAPSD 211
+ EE+ L ++E DEE+ G+ SD
Sbjct: 574 NREEQEELMDFERDEERSANGGSESD 599
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 39.7 bits (91), Expect = 0.003
Identities = 28/99 (28%), Positives = 52/99 (52%), Gaps = 6/99 (6%)
Query: 113 QKKEERDLVNRLKVEQ---ARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSR 169
+++ ER+ + R ++EQ R +Q ER ++L+ + +L+ + RQE + E R R
Sbjct: 173 RERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQER 232
Query: 170 EMLETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGA 208
E LE E Q +E+L + E + E++++S A
Sbjct: 233 ERLE---RLERERQERERQEQLEREQLEWERERRISSAA 268
Score = 31.2 bits (69), Expect = 1.1
Identities = 53/206 (25%), Positives = 80/206 (38%), Gaps = 32/206 (15%)
Query: 90 SSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRLKVEQARRKQRE-ERLQ-QLQHRVQL 147
+S E PR + Q +EE ++ R EQ R+K+ E ERL+ + R +L
Sbjct: 112 NSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERL 171
Query: 148 --------KYAAKRLRQEEEETENLLRLSREMLETGPEAEWLEQLESGEE---------- 189
+ +RL QE+ E E R +E LE E E+LE E
Sbjct: 172 ERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQE 231
Query: 190 ----ELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQRTRPSSVLSEDLLM 245
E + E + E ++ + R A+ PA++ T +SVL +
Sbjct: 232 RERLERLERERQERERQEQLEREQLEWERERRISSAAAPASV----ETPLNSVLGDSSAS 287
Query: 246 QRAV--AKHPALLPSQMS--SSPLRP 267
+ + A PA PSQ PL P
Sbjct: 288 EPGLQAASQPAETPSQQGIVLGPLAP 313
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 39.7 bits (91), Expect = 0.003
Identities = 28/99 (28%), Positives = 52/99 (52%), Gaps = 6/99 (6%)
Query: 113 QKKEERDLVNRLKVEQ---ARRKQREERLQQLQHRVQLKYAAKRLRQEEEETENLLRLSR 169
+++ ER+ + R ++EQ R +Q ER ++L+ + +L+ + RQE + E R R
Sbjct: 173 RERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQER 232
Query: 170 EMLETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGA 208
E LE E Q +E+L + E + E++++S A
Sbjct: 233 ERLE---RLERERQERERQEQLEREQLEWERERRISSAA 268
Score = 31.2 bits (69), Expect = 1.1
Identities = 53/206 (25%), Positives = 80/206 (38%), Gaps = 32/206 (15%)
Query: 90 SSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVNRLKVEQARRKQRE-ERLQ-QLQHRVQL 147
+S E PR + Q +EE ++ R EQ R+K+ E ERL+ + R +L
Sbjct: 112 NSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERL 171
Query: 148 --------KYAAKRLRQEEEETENLLRLSREMLETGPEAEWLEQLESGEE---------- 189
+ +RL QE+ E E R +E LE E E+LE E
Sbjct: 172 ERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQE 231
Query: 190 ----ELVLAEYESDEEKKVASGAPSDATSSRHPPDASFPAALNFLQRTRPSSVLSEDLLM 245
E + E + E ++ + R A+ PA++ T +SVL +
Sbjct: 232 RERLERLERERQERERQEQLEREQLEWERERRISSAAAPASV----ETPLNSVLGDSSAS 287
Query: 246 QRAV--AKHPALLPSQMS--SSPLRP 267
+ + A PA PSQ PL P
Sbjct: 288 EPGLQAASQPAETPSQQGIVLGPLAP 313
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 39.3 bits (90), Expect = 0.004
Identities = 43/170 (25%), Positives = 67/170 (39%), Gaps = 34/170 (20%)
Query: 59 FEQKKREEEARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEER 118
+E+K ++ E RL E L + K R E +T + +K+EE
Sbjct: 772 YEEKLKQFEERLAEERHNRLEERK-----------------RQRKEERRITYYREKEEEE 814
Query: 119 D-------LVNRLKVEQARRKQREERLQQLQHRV-QLKYAAKRLRQEEEETENLLRLSRE 170
L R + E+A R +REE L++ Q RV +L+ ++ RQ E E E R E
Sbjct: 815 QRRAEEQMLKEREERERAERAKREEELREYQERVKKLEEVERKKRQRELEIEERERRREE 874
Query: 171 MLETGPEAEWLEQLESGEEELVLAEYESDEEKKVASGAPSDATSSRHPPD 220
G + + G+ D E G +D+ R PP+
Sbjct: 875 ERRLGDSSLSRKDSRWGDR---------DSEGTWRKGPEADSEWRRGPPE 915
Score = 31.2 bits (69), Expect = 1.1
Identities = 25/81 (30%), Positives = 44/81 (54%), Gaps = 8/81 (9%)
Query: 110 QFVQKKEERDLVNRLKVEQARRKQREERLQQLQHRVQLKYAAKRLRQE--EEETENLLRL 167
Q +++++ER ++ E+ +QRE LQ+++ K +RLRQE E E E +L+
Sbjct: 573 QTIEERKERLESLNIQREKEELEQREAELQKVR-----KAEEERLRQEAKEREKERILQ- 626
Query: 168 SREMLETGPEAEWLEQLESGE 188
E ++ E LEQ++ E
Sbjct: 627 EHEQIKKKTVRERLEQIKKTE 647
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.127 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,554,569
Number of Sequences: 37866
Number of extensions: 630260
Number of successful extensions: 5603
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 156
Number of HSP's successfully gapped in prelim test: 486
Number of HSP's that attempted gapping in prelim test: 3590
Number of HSP's gapped (non-prelim): 1756
length of query: 282
length of database: 18,247,518
effective HSP length: 101
effective length of query: 181
effective length of database: 14,423,052
effective search space: 2610572412
effective search space used: 2610572412
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.