Search of human proteins with 116256487

Search of human proteins with 116256487

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|116256487 patatin-like phospholipase domain containing 6
[Homo sapiens]
         (1327 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|116256487 patatin-like phospholipase domain containing 6 [Hom...  2648   0.0  
gi|148727335 patatin-like phospholipase domain containing 7 isof...  1553   0.0  
gi|148727290 patatin-like phospholipase domain containing 7 isof...  1551   0.0  
gi|38257139 protein kinase, cAMP-dependent, regulatory, type I, ...    49   2e-05
gi|47132583 cAMP-dependent protein kinase, regulatory subunit al...    48   5e-05
gi|47132581 cAMP-dependent protein kinase, regulatory subunit al...    48   5e-05
gi|4506063 cAMP-dependent protein kinase, regulatory subunit alp...    48   5e-05
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof...    47   1e-04
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof...    47   1e-04
gi|47132585 cAMP-dependent protein kinase, regulatory subunit be...    47   1e-04
gi|117938768 GNAS complex locus alex [Homo sapiens]                    47   2e-04
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ...    45   5e-04
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [...    45   5e-04
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ...    45   5e-04
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]     42   0.003
gi|33286446 opioid growth factor receptor [Homo sapiens]               42   0.005
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [...    41   0.007
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H...    41   0.007
gi|4758958 cAMP-dependent protein kinase, regulatory subunit alp...    41   0.007
gi|116256354 alpha 2 type IV collagen preproprotein [Homo sapiens]     41   0.009
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [...    40   0.011
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho...    40   0.011
gi|72004269 tetra-peptide repeat homeobox [Homo sapiens]               40   0.015
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H...    40   0.019
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]               39   0.033
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...    38   0.057
gi|145309322 insulinoma-associated protein IA-6 [Homo sapiens]         38   0.057
gi|24431935 reticulon 4 isoform A [Homo sapiens]                       37   0.096
gi|197245373 proline rich 22 isoform 1 [Homo sapiens]                  37   0.13 
gi|23503299 proline rich 22 isoform 2 [Homo sapiens]                   37   0.13 

>gi|116256487 patatin-like phospholipase domain containing 6 [Homo
            sapiens]
          Length = 1327

 Score = 2648 bits (6863), Expect = 0.0
 Identities = 1327/1327 (100%), Positives = 1327/1327 (100%)

Query: 1    MEAPLQTGMVLGVMIGAGVAVVVTAVLILLVVRRLRVPKTPAPDGPRYRFRKRDKVLFYG 60
            MEAPLQTGMVLGVMIGAGVAVVVTAVLILLVVRRLRVPKTPAPDGPRYRFRKRDKVLFYG
Sbjct: 1    MEAPLQTGMVLGVMIGAGVAVVVTAVLILLVVRRLRVPKTPAPDGPRYRFRKRDKVLFYG 60

Query: 61   RKIMRKVSQSTSSLVDTSVSATSRPRMRKKLKMLNIAKKILRIQKETPTLQRKEPPPAVL 120
            RKIMRKVSQSTSSLVDTSVSATSRPRMRKKLKMLNIAKKILRIQKETPTLQRKEPPPAVL
Sbjct: 61   RKIMRKVSQSTSSLVDTSVSATSRPRMRKKLKMLNIAKKILRIQKETPTLQRKEPPPAVL 120

Query: 121  EADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQP 180
            EADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQP
Sbjct: 121  EADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQP 180

Query: 181  DASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAA 240
            DASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAA
Sbjct: 181  DASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAA 240

Query: 241  RDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQP 300
            RDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQP
Sbjct: 241  RDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQP 300

Query: 301  LRLFPSPGLPTRTSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLE 360
            LRLFPSPGLPTRTSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLE
Sbjct: 301  LRLFPSPGLPTRTSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLE 360

Query: 361  TPSAPLLSRCVSMPGDISGLQGGPRSDFDMAYERGRISVSLQEEASGGSLAAPARTPTQE 420
            TPSAPLLSRCVSMPGDISGLQGGPRSDFDMAYERGRISVSLQEEASGGSLAAPARTPTQE
Sbjct: 361  TPSAPLLSRCVSMPGDISGLQGGPRSDFDMAYERGRISVSLQEEASGGSLAAPARTPTQE 420

Query: 421  PREQPAGACEYSYCEDESATGGCPFGPYQGRQTSSIFEAAKQELAKLMRIEDPSLLNSRV 480
            PREQPAGACEYSYCEDESATGGCPFGPYQGRQTSSIFEAAKQELAKLMRIEDPSLLNSRV
Sbjct: 421  PREQPAGACEYSYCEDESATGGCPFGPYQGRQTSSIFEAAKQELAKLMRIEDPSLLNSRV 480

Query: 481  LLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLAVLT 540
            LLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLAVLT
Sbjct: 481  LLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLAVLT 540

Query: 541  GEPLIFTLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWT 600
            GEPLIFTLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWT
Sbjct: 541  GEPLIFTLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWT 600

Query: 601  AVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPR 660
            AVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPR
Sbjct: 601  AVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPR 660

Query: 661  ATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPAGSGLG 720
            ATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPAGSGLG
Sbjct: 661  ATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPAGSGLG 720

Query: 721  VPPHSELTNPASNLATVAILPVCAEVPMVAFTLELQHALQAIGPTLLLNSDIIRARLGAS 780
            VPPHSELTNPASNLATVAILPVCAEVPMVAFTLELQHALQAIGPTLLLNSDIIRARLGAS
Sbjct: 721  VPPHSELTNPASNLATVAILPVCAEVPMVAFTLELQHALQAIGPTLLLNSDIIRARLGAS 780

Query: 781  ALDSIQEFRLSGWLAQQEDAHRIVLYQTDASLTPWTVRCLRQADCILIVGLGDQEPTLGQ 840
            ALDSIQEFRLSGWLAQQEDAHRIVLYQTDASLTPWTVRCLRQADCILIVGLGDQEPTLGQ
Sbjct: 781  ALDSIQEFRLSGWLAQQEDAHRIVLYQTDASLTPWTVRCLRQADCILIVGLGDQEPTLGQ 840

Query: 841  LEQMLENTAVRALKQLVLLHREEGAGPTRTVEWLNMRSWCSGHLHLRCPRRLFSRRSPAK 900
            LEQMLENTAVRALKQLVLLHREEGAGPTRTVEWLNMRSWCSGHLHLRCPRRLFSRRSPAK
Sbjct: 841  LEQMLENTAVRALKQLVLLHREEGAGPTRTVEWLNMRSWCSGHLHLRCPRRLFSRRSPAK 900

Query: 901  LHELYEKVFSRRADRHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEEAGVPVD 960
            LHELYEKVFSRRADRHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEEAGVPVD
Sbjct: 901  LHELYEKVFSRRADRHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEEAGVPVD 960

Query: 961  LVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFTGSAFNR 1020
            LVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFTGSAFNR
Sbjct: 961  LVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFTGSAFNR 1020

Query: 1021 SIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKD 1080
            SIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKD
Sbjct: 1021 SIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKD 1080

Query: 1081 GHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWA 1140
            GHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWA
Sbjct: 1081 GHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWA 1140

Query: 1141 DKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPPIDCFKTMDFGKFDQIYDVGYQ 1200
            DKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPPIDCFKTMDFGKFDQIYDVGYQ
Sbjct: 1141 DKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPPIDCFKTMDFGKFDQIYDVGYQ 1200

Query: 1201 YGKAVFGGWSRGNVIEKMLTDRRSTDLNESRRADVLAFPSSGFTDLAEIVSRIEPPTSYV 1260
            YGKAVFGGWSRGNVIEKMLTDRRSTDLNESRRADVLAFPSSGFTDLAEIVSRIEPPTSYV
Sbjct: 1201 YGKAVFGGWSRGNVIEKMLTDRRSTDLNESRRADVLAFPSSGFTDLAEIVSRIEPPTSYV 1260

Query: 1261 SDGCADGEESDCLTEYEEDAGPDCSRDEGGSPEGASPSTASEMEEEKSILRQRRCLPQEP 1320
            SDGCADGEESDCLTEYEEDAGPDCSRDEGGSPEGASPSTASEMEEEKSILRQRRCLPQEP
Sbjct: 1261 SDGCADGEESDCLTEYEEDAGPDCSRDEGGSPEGASPSTASEMEEEKSILRQRRCLPQEP 1320

Query: 1321 PGSATDA 1327
            PGSATDA
Sbjct: 1321 PGSATDA 1327


>gi|148727335 patatin-like phospholipase domain containing 7 isoform a
            [Homo sapiens]
          Length = 1342

 Score = 1553 bits (4020), Expect = 0.0
 Identities = 823/1335 (61%), Positives = 998/1335 (74%), Gaps = 50/1335 (3%)

Query: 9    MVLGVMIGAGVAVVVTAVLILLVVRRLRVPKTPAPDGPRYRFRKRDKVLFYGRKIMRKVS 68
            M+ G+ +GA +A+ +  VLIL + RRLR  +   P  P+YRFRKRDKV+FYGRKIMRKV+
Sbjct: 35   MLTGIAVGALLALALVGVLILFMFRRLRQFRQAQPT-PQYRFRKRDKVMFYGRKIMRKVT 93

Query: 69   QSTSSLVDTSVSATSRPRMRKKLKMLNIAKKILRIQKETPTLQRKEPPPAVLEADLTEGD 128
               ++LV+ +  A  R R RK+ K+L++AK+ILR +KE P LQ KEPPP++LEADLTE D
Sbjct: 94   TLPNTLVENT--ALPRQRARKRTKVLSLAKRILRFKKEYPALQPKEPPPSLLEADLTEFD 151

Query: 129  LANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQ 188
            + NSHLPSEVLYMLKNVRVLGHFEKPLFLELC+H+VF +L +G++VF+P +PD SI VVQ
Sbjct: 152  VKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHIVFVQLQEGEHVFQPREPDPSICVVQ 211

Query: 189  DGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRL 248
            DG LE+C+   DG E VVKEV+ GDSV+SLLSILD+ITGH  P +TVS RAA  ST+LRL
Sbjct: 212  DGRLEVCIQDTDGTEVVVKEVLAGDSVHSLLSILDIITGHAAPYKTVSVRAAIPSTILRL 271

Query: 249  PVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPG 308
            P  AF  VF KYPE+LVRVVQIIMVRLQRVTFLALHNYLGLT ELF+ E Q + L     
Sbjct: 272  PAAAFHGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNAESQAIPLV---- 327

Query: 309  LPTRTSPVRGSKRMVSTSATDEPRETPGRPPDPT----GAPLPGPTGDPVKPTSLETPSA 364
              +  S   G  +       +E  + P R  +      G   P   G P+   S   P+ 
Sbjct: 328  --SVASVAAGKAKKQVFYGEEERLKKPPRLQESCDSDHGGGRPAAAG-PLLKRSHSVPAP 384

Query: 365  PLLSRCVS---MPG----DISGLQGGP---RSDFDMAYERGRISVSLQEEASGGSLAAPA 414
             +  + +     PG    D S  QGGP    SD  MA +R R+ +   +E  G S+A+ +
Sbjct: 385  SIRKQILEELEKPGAGDPDPSAPQGGPGSATSDLGMACDRARVFLH-SDEHPGSSVASKS 443

Query: 415  RTPTQEPREQPAGACEYSYCEDESATGGCPFGPYQGRQTSSIFEAAKQELAKLMRIEDPS 474
            R       E P+   ++S    +             R++ +IF AAK++L  LM++ED S
Sbjct: 444  RKSVMVA-EIPSTVSQHSESHTDETLAS--------RKSDAIFRAAKKDLLTLMKLEDSS 494

Query: 475  LLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVG 534
            LL+ RV L H  AGT+++RQGDQD S+ FV+ G LHVYQR I   ED CLF+ +PGE+VG
Sbjct: 495  LLDGRVALLHVPAGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCLFLTRPGEMVG 554

Query: 535  QLAVLTGEPLIFTLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMD 594
            QLAVLTGEPLIFT++A RDC+FL ISK+ FYEIMR QP+VVL  AHTV  RMS FVRQ+D
Sbjct: 555  QLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIMRKQPTVVLGVAHTVVKRMSSFVRQID 614

Query: 595  FAIDWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEA 654
            FA+DW  VEAGRA+YRQGD+SDCTYI+L+GRLRSVI++  GKK L GEYGRGDL+GVVE 
Sbjct: 615  FALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVET 674

Query: 655  LTRQPRATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFP 714
            LT Q RATTVHAVRD+ELAKLP G L  IKRRYPQVVTRLIHLL +KILG+LQQ  GP  
Sbjct: 675  LTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQ--GPV- 731

Query: 715  AGSGLGVPPHS---ELTNPASNLATVAILPVCAEVPMVAFTLELQHALQAIGPTLLLNSD 771
             G  LG+P      +L NPA NL+TVA++PV  EVP+ AF LEL+HAL AIGPTLLL SD
Sbjct: 732  TGHQLGLPTEGSKWDLGNPAVNLSTVAVMPVSEEVPLTAFALELEHALSAIGPTLLLTSD 791

Query: 772  IIRARLGASALDSIQEFRLSGWLAQQEDAHRIVLYQTDASLTPWTVRCLRQADCILIVGL 831
             I+ RLG++ALDS+ E+RLS WL QQED HRIVLYQ D +LTPWT RC+RQADCILIVGL
Sbjct: 792  NIKRRLGSAALDSVHEYRLSSWLGQQEDTHRIVLYQVDGTLTPWTQRCVRQADCILIVGL 851

Query: 832  GDQEPTLGQLEQMLENTAVRALKQLVLLHREEGAGPTRTVEWLNMRSWCSGHLHLRCPRR 891
            GDQEPT+G+LE+MLE+TAVRA KQL+LLHREEG  P RTVEWLNMRSWCSGHLHL CPRR
Sbjct: 852  GDQEPTVGELERMLESTAVRAQKQLILLHREEGPAPARTVEWLNMRSWCSGHLHLCCPRR 911

Query: 892  LFSRRSPAKLHELYEKVFSRRADRHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKA 951
            +FSRRS  KL E+Y+ VF R  DRHSDFSRLARVLTGN IALVLGGGGARGC+ +GVLKA
Sbjct: 912  VFSRRSLPKLVEMYKHVFQRPPDRHSDFSRLARVLTGNAIALVLGGGGARGCAQVGVLKA 971

Query: 952  LEEAGVPVDLVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTS 1011
            L E G+PVD+VGGTSIG+F+GALY+EER+ S+ + RA++WA+ MTS+++  LDLTYP+TS
Sbjct: 972  LAECGIPVDMVGGTSIGAFVGALYSEERNYSQMRIRAKQWAEGMTSLMKAALDLTYPITS 1031

Query: 1012 MFTGSAFNRSIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGY 1071
            MF+G+ FN SI  VF+D+QIEDLW+PYF +TTDITASAMRVH DGSLW YVRASM+LSGY
Sbjct: 1032 MFSGAGFNSSIFSVFKDQQIEDLWIPYFAITTDITASAMRVHTDGSLWWYVRASMSLSGY 1091

Query: 1072 LPPLCDPKDGHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWL 1131
            +PPLCDPKDGHLLMDGGYINNLPAD+ARSMGAK VIAIDVGS+DETDL+ YGD+LSGWWL
Sbjct: 1092 MPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWL 1151

Query: 1132 LWKRLNPWADKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPPIDCFKTMDFGKF 1191
            LWKR NP A KVKV +MAEIQ+RLAYV CVRQLEVVKSS YCEYLRPPID + T+DFGKF
Sbjct: 1152 LWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEVVKSSDYCEYLRPPIDSYSTLDFGKF 1211

Query: 1192 DQIYDVGYQYGKAVFGGWSRGNVIEKMLTDRRSTDLNESRRADVLAFPSSGFTDLAEIVS 1251
            ++I +VGYQ+G+ VF  W R  V+EKML D++    ++   + VL  P++ FTDLAEIVS
Sbjct: 1212 NEICEVGYQHGRTVFDIWGRSGVLEKMLRDQQGP--SKKPASAVLTCPNASFTDLAEIVS 1269

Query: 1252 RIEPPTSYVSDGCADGEESDCLTEYEEDAGPDCSRDEGGSPEGASPSTASEMEEEKSILR 1311
            RIEP    + D     +ESD  TEYEE+   D  RD     +  S    S++E+E S+  
Sbjct: 1270 RIEPAKPAMVD-----DESDYQTEYEEEL-LDVPRDAYADFQSTSAQQGSDLEDESSLRH 1323

Query: 1312 QRRCL--PQEPPGSA 1324
            +   L  P+   GS+
Sbjct: 1324 RHPSLAFPKLSEGSS 1338


>gi|148727290 patatin-like phospholipase domain containing 7 isoform b
            [Homo sapiens]
          Length = 1317

 Score = 1551 bits (4015), Expect = 0.0
 Identities = 822/1332 (61%), Positives = 996/1332 (74%), Gaps = 50/1332 (3%)

Query: 12   GVMIGAGVAVVVTAVLILLVVRRLRVPKTPAPDGPRYRFRKRDKVLFYGRKIMRKVSQST 71
            G+ +GA +A+ +  VLIL + RRLR  +   P  P+YRFRKRDKV+FYGRKIMRKV+   
Sbjct: 13   GIAVGALLALALVGVLILFMFRRLRQFRQAQPT-PQYRFRKRDKVMFYGRKIMRKVTTLP 71

Query: 72   SSLVDTSVSATSRPRMRKKLKMLNIAKKILRIQKETPTLQRKEPPPAVLEADLTEGDLAN 131
            ++LV+ +  A  R R RK+ K+L++AK+ILR +KE P LQ KEPPP++LEADLTE D+ N
Sbjct: 72   NTLVENT--ALPRQRARKRTKVLSLAKRILRFKKEYPALQPKEPPPSLLEADLTEFDVKN 129

Query: 132  SHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGL 191
            SHLPSEVLYMLKNVRVLGHFEKPLFLELC+H+VF +L +G++VF+P +PD SI VVQDG 
Sbjct: 130  SHLPSEVLYMLKNVRVLGHFEKPLFLELCKHIVFVQLQEGEHVFQPREPDPSICVVQDGR 189

Query: 192  LELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVE 251
            LE+C+   DG E VVKEV+ GDSV+SLLSILD+ITGH  P +TVS RAA  ST+LRLP  
Sbjct: 190  LEVCIQDTDGTEVVVKEVLAGDSVHSLLSILDIITGHAAPYKTVSVRAAIPSTILRLPAA 249

Query: 252  AFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPT 311
            AF  VF KYPE+LVRVVQIIMVRLQRVTFLALHNYLGLT ELF+ E Q + L       +
Sbjct: 250  AFHGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNAESQAIPLV------S 303

Query: 312  RTSPVRGSKRMVSTSATDEPRETPGRPPDPT----GAPLPGPTGDPVKPTSLETPSAPLL 367
              S   G  +       +E  + P R  +      G   P   G P+   S   P+  + 
Sbjct: 304  VASVAAGKAKKQVFYGEEERLKKPPRLQESCDSDHGGGRPAAAG-PLLKRSHSVPAPSIR 362

Query: 368  SRCVS---MPG----DISGLQGGP---RSDFDMAYERGRISVSLQEEASGGSLAAPARTP 417
             + +     PG    D S  QGGP    SD  MA +R R+ +   +E  G S+A+ +R  
Sbjct: 363  KQILEELEKPGAGDPDPSAPQGGPGSATSDLGMACDRARVFLH-SDEHPGSSVASKSRKS 421

Query: 418  TQEPREQPAGACEYSYCEDESATGGCPFGPYQGRQTSSIFEAAKQELAKLMRIEDPSLLN 477
                 E P+   ++S    +             R++ +IF AAK++L  LM++ED SLL+
Sbjct: 422  VMVA-EIPSTVSQHSESHTDETLAS--------RKSDAIFRAAKKDLLTLMKLEDSSLLD 472

Query: 478  SRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLA 537
             RV L H  AGT+++RQGDQD S+ FV+ G LHVYQR I   ED CLF+ +PGE+VGQLA
Sbjct: 473  GRVALLHVPAGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCLFLTRPGEMVGQLA 532

Query: 538  VLTGEPLIFTLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAI 597
            VLTGEPLIFT++A RDC+FL ISK+ FYEIMR QP+VVL  AHTV  RMS FVRQ+DFA+
Sbjct: 533  VLTGEPLIFTVKANRDCSFLSISKAHFYEIMRKQPTVVLGVAHTVVKRMSSFVRQIDFAL 592

Query: 598  DWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTR 657
            DW  VEAGRA+YRQGD+SDCTYI+L+GRLRSVI++  GKK L GEYGRGDL+GVVE LT 
Sbjct: 593  DWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTH 652

Query: 658  QPRATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPAGS 717
            Q RATTVHAVRD+ELAKLP G L  IKRRYPQVVTRLIHLL +KILG+LQQ  GP   G 
Sbjct: 653  QARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQ--GPV-TGH 709

Query: 718  GLGVPPHS---ELTNPASNLATVAILPVCAEVPMVAFTLELQHALQAIGPTLLLNSDIIR 774
             LG+P      +L NPA NL+TVA++PV  EVP+ AF LEL+HAL AIGPTLLL SD I+
Sbjct: 710  QLGLPTEGSKWDLGNPAVNLSTVAVMPVSEEVPLTAFALELEHALSAIGPTLLLTSDNIK 769

Query: 775  ARLGASALDSIQEFRLSGWLAQQEDAHRIVLYQTDASLTPWTVRCLRQADCILIVGLGDQ 834
             RLG++ALDS+ E+RLS WL QQED HRIVLYQ D +LTPWT RC+RQADCILIVGLGDQ
Sbjct: 770  RRLGSAALDSVHEYRLSSWLGQQEDTHRIVLYQVDGTLTPWTQRCVRQADCILIVGLGDQ 829

Query: 835  EPTLGQLEQMLENTAVRALKQLVLLHREEGAGPTRTVEWLNMRSWCSGHLHLRCPRRLFS 894
            EPT+G+LE+MLE+TAVRA KQL+LLHREEG  P RTVEWLNMRSWCSGHLHL CPRR+FS
Sbjct: 830  EPTVGELERMLESTAVRAQKQLILLHREEGPAPARTVEWLNMRSWCSGHLHLCCPRRVFS 889

Query: 895  RRSPAKLHELYEKVFSRRADRHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEE 954
            RRS  KL E+Y+ VF R  DRHSDFSRLARVLTGN IALVLGGGGARGC+ +GVLKAL E
Sbjct: 890  RRSLPKLVEMYKHVFQRPPDRHSDFSRLARVLTGNAIALVLGGGGARGCAQVGVLKALAE 949

Query: 955  AGVPVDLVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFT 1014
             G+PVD+VGGTSIG+F+GALY+EER+ S+ + RA++WA+ MTS+++  LDLTYP+TSMF+
Sbjct: 950  CGIPVDMVGGTSIGAFVGALYSEERNYSQMRIRAKQWAEGMTSLMKAALDLTYPITSMFS 1009

Query: 1015 GSAFNRSIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPP 1074
            G+ FN SI  VF+D+QIEDLW+PYF +TTDITASAMRVH DGSLW YVRASM+LSGY+PP
Sbjct: 1010 GAGFNSSIFSVFKDQQIEDLWIPYFAITTDITASAMRVHTDGSLWWYVRASMSLSGYMPP 1069

Query: 1075 LCDPKDGHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWK 1134
            LCDPKDGHLLMDGGYINNLPAD+ARSMGAK VIAIDVGS+DETDL+ YGD+LSGWWLLWK
Sbjct: 1070 LCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWK 1129

Query: 1135 RLNPWADKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPPIDCFKTMDFGKFDQI 1194
            R NP A KVKV +MAEIQ+RLAYV CVRQLEVVKSS YCEYLRPPID + T+DFGKF++I
Sbjct: 1130 RWNPLATKVKVLNMAEIQTRLAYVCCVRQLEVVKSSDYCEYLRPPIDSYSTLDFGKFNEI 1189

Query: 1195 YDVGYQYGKAVFGGWSRGNVIEKMLTDRRSTDLNESRRADVLAFPSSGFTDLAEIVSRIE 1254
             +VGYQ+G+ VF  W R  V+EKML D++    ++   + VL  P++ FTDLAEIVSRIE
Sbjct: 1190 CEVGYQHGRTVFDIWGRSGVLEKMLRDQQGP--SKKPASAVLTCPNASFTDLAEIVSRIE 1247

Query: 1255 PPTSYVSDGCADGEESDCLTEYEEDAGPDCSRDEGGSPEGASPSTASEMEEEKSILRQRR 1314
            P    + D     +ESD  TEYEE+   D  RD     +  S    S++E+E S+  +  
Sbjct: 1248 PAKPAMVD-----DESDYQTEYEEEL-LDVPRDAYADFQSTSAQQGSDLEDESSLRHRHP 1301

Query: 1315 CL--PQEPPGSA 1324
             L  P+   GS+
Sbjct: 1302 SLAFPKLSEGSS 1313


>gi|38257139 protein kinase, cAMP-dependent, regulatory, type I,
           beta [Homo sapiens]
          Length = 381

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 63/285 (22%), Positives = 114/285 (40%), Gaps = 19/285 (6%)

Query: 402 QEEASGGSLAAPARTPTQEPREQPAGACEYSYCEDESATGGCPFGPYQGRQTSSIFEAAK 461
           Q ++    ++     P  + R +  G     Y E+++ +      P   +  +++ +A  
Sbjct: 74  QSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAIS 133

Query: 462 QEL--AKLMRIEDPSLLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKA 519
           + +  A L   E   + ++   + H  AG  + +QG++  + + V  G + VY       
Sbjct: 134 KNVLFAHLDDNERSDIFDAMFPVTHI-AGETVIQQGNEGDNFYVVDQGEVDVY------V 186

Query: 520 EDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLRISKSDFYEIM-------RAQP 572
               +     G   G+LA++ G P   T++A+ D     I +  +  I+       R   
Sbjct: 187 NGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMY 246

Query: 573 SVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQR 632
              LS    + +        +  A++    E G  +  QG+  D  YI+  G   SV+QR
Sbjct: 247 EEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEG-TASVLQR 305

Query: 633 GSGKKEL--VGEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKL 675
            S  +E   VG  G  D  G +  L  +PRA TV A    +  KL
Sbjct: 306 RSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKL 350


>gi|47132583 cAMP-dependent protein kinase, regulatory subunit alpha
           1 [Homo sapiens]
          Length = 381

 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 49/199 (24%), Positives = 85/199 (42%), Gaps = 18/199 (9%)

Query: 487 AGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIF 546
           AG  + +QGD+  + + +  G   VY        +    V + G   G+LA++ G P   
Sbjct: 160 AGETVIQQGDEGDNFYVIDQGETDVYVN-----NEWATSVGEGGSF-GELALIYGTPRAA 213

Query: 547 TLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMD--------FAID 598
           T++A+ +     I +  +  I+               +++S  +  +D         A++
Sbjct: 214 TVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVS-ILESLDKWERLTVADALE 272

Query: 599 WTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKEL--VGEYGRGDLIGVVEALT 656
               E G+ +  QG+  D  +I+L G   +V+QR S  +E   VG  G  D  G +  L 
Sbjct: 273 PVQFEDGQKIVVQGEPGDEFFIILEGS-AAVLQRRSENEEFVEVGRLGPSDYFGEIALLM 331

Query: 657 RQPRATTVHAVRDTELAKL 675
            +PRA TV A    +  KL
Sbjct: 332 NRPRAATVVARGPLKCVKL 350


>gi|47132581 cAMP-dependent protein kinase, regulatory subunit alpha
           1 [Homo sapiens]
          Length = 381

 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 49/199 (24%), Positives = 85/199 (42%), Gaps = 18/199 (9%)

Query: 487 AGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIF 546
           AG  + +QGD+  + + +  G   VY        +    V + G   G+LA++ G P   
Sbjct: 160 AGETVIQQGDEGDNFYVIDQGETDVYVN-----NEWATSVGEGGSF-GELALIYGTPRAA 213

Query: 547 TLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMD--------FAID 598
           T++A+ +     I +  +  I+               +++S  +  +D         A++
Sbjct: 214 TVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVS-ILESLDKWERLTVADALE 272

Query: 599 WTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKEL--VGEYGRGDLIGVVEALT 656
               E G+ +  QG+  D  +I+L G   +V+QR S  +E   VG  G  D  G +  L 
Sbjct: 273 PVQFEDGQKIVVQGEPGDEFFIILEGS-AAVLQRRSENEEFVEVGRLGPSDYFGEIALLM 331

Query: 657 RQPRATTVHAVRDTELAKL 675
            +PRA TV A    +  KL
Sbjct: 332 NRPRAATVVARGPLKCVKL 350


>gi|4506063 cAMP-dependent protein kinase, regulatory subunit alpha
           1 [Homo sapiens]
          Length = 381

 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 49/199 (24%), Positives = 85/199 (42%), Gaps = 18/199 (9%)

Query: 487 AGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIF 546
           AG  + +QGD+  + + +  G   VY        +    V + G   G+LA++ G P   
Sbjct: 160 AGETVIQQGDEGDNFYVIDQGETDVYVN-----NEWATSVGEGGSF-GELALIYGTPRAA 213

Query: 547 TLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMD--------FAID 598
           T++A+ +     I +  +  I+               +++S  +  +D         A++
Sbjct: 214 TVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVS-ILESLDKWERLTVADALE 272

Query: 599 WTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKEL--VGEYGRGDLIGVVEALT 656
               E G+ +  QG+  D  +I+L G   +V+QR S  +E   VG  G  D  G +  L 
Sbjct: 273 PVQFEDGQKIVVQGEPGDEFFIILEGS-AAVLQRRSENEEFVEVGRLGPSDYFGEIALLM 331

Query: 657 RQPRATTVHAVRDTELAKL 675
            +PRA TV A    +  KL
Sbjct: 332 NRPRAATVVARGPLKCVKL 350


>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
           b [Homo sapiens]
          Length = 867

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 37/127 (29%), Positives = 60/127 (47%), Gaps = 12/127 (9%)

Query: 450 GRQTSSIFEAAKQELAKLMRIEDPSLLNSRVLL------HHAKAGTIIARQGDQDVSLHF 503
           G++T    E   +EL  +  +   S    R L        HAK GT++  QG++  S + 
Sbjct: 193 GQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYI 252

Query: 504 VLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRD-CTFLRISKS 562
           +L G ++V   +I     VC      G+  G+LA++   P   ++  + D C FLR+ K 
Sbjct: 253 ILKGSVNV---VIYGKGVVC--TLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKE 307

Query: 563 DFYEIMR 569
           DF  I+R
Sbjct: 308 DFNRILR 314


>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform
           a [Homo sapiens]
          Length = 1011

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 37/127 (29%), Positives = 60/127 (47%), Gaps = 12/127 (9%)

Query: 450 GRQTSSIFEAAKQELAKLMRIEDPSLLNSRVLL------HHAKAGTIIARQGDQDVSLHF 503
           G++T    E   +EL  +  +   S    R L        HAK GT++  QG++  S + 
Sbjct: 337 GQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYI 396

Query: 504 VLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRD-CTFLRISKS 562
           +L G ++V   +I     VC      G+  G+LA++   P   ++  + D C FLR+ K 
Sbjct: 397 ILKGSVNV---VIYGKGVVC--TLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKE 451

Query: 563 DFYEIMR 569
           DF  I+R
Sbjct: 452 DFNRILR 458



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 31/119 (26%), Positives = 49/119 (41%), Gaps = 6/119 (5%)

Query: 142 LKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDG 201
           LK V+    F   L  ++C    ++ L +G  +FR G    + Y V  G L++ +     
Sbjct: 38  LKEVKAFEKFHPNLLHQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSS 97

Query: 202 KECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKY 260
            +  V     G       SILD    H     T+  R    S +LR+  + F A++ KY
Sbjct: 98  HQDAVTICTLGIGTAFGESILDNTPRH----ATIVTR--ESSELLRIEQKDFKALWEKY 150



 Score = 31.6 bits (70), Expect = 5.3
 Identities = 26/96 (27%), Positives = 40/96 (41%), Gaps = 3/96 (3%)

Query: 602 VEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVG--EYGRGDLIGVVEALTRQP 659
           +E G  L+RQGD     Y VL G L   +   S  ++ V     G G   G    L   P
Sbjct: 64  LEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFG-ESILDNTP 122

Query: 660 RATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLI 695
           R  T+     +EL ++ +     +  +Y Q +  L+
Sbjct: 123 RHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLL 158


>gi|47132585 cAMP-dependent protein kinase, regulatory subunit beta
           2 [Homo sapiens]
          Length = 418

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 67/314 (21%), Positives = 118/314 (37%), Gaps = 25/314 (7%)

Query: 375 GDISGLQGG--PRSDFDMAYERGRI-SVSLQEEASGGSLAAPARTPTQEPREQPAGACEY 431
           GD+    GG  P    + A E  +  S   +EE +  + A     P      + A  C  
Sbjct: 59  GDLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAE 118

Query: 432 SYCEDESATGGCP--FGPYQGRQTSSIFEAAKQELA-KLMRIEDPSLLNSRVLLHHAKAG 488
           +Y  DE           P    Q + + EA K  L  K +  E  S +   +     K G
Sbjct: 119 AYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDG 178

Query: 489 TIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIFTL 548
             +  QGD   + + +  G   +Y +        C+         G+LA++   P   T+
Sbjct: 179 EHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGR--CVGNYDNRGSFGELALMYNTPRAATI 236

Query: 549 RAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEA---- 604
            A        + +  F  I+  + +      +       PF++ ++F+     V+     
Sbjct: 237 TATSPGALWGLDRVTFRRII-VKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTK 295

Query: 605 ----GRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKEL-------VGEYGRGDLIGVVE 653
               G  +  QGD +D  +IV +G ++  ++R  GK E+       +    RG   G + 
Sbjct: 296 VYNDGEQIIAQGDSADSFFIVESGEVKITMKR-KGKSEVEENGAVEIARCSRGQYFGELA 354

Query: 654 ALTRQPRATTVHAV 667
            +T +PRA + HA+
Sbjct: 355 LVTNKPRAASAHAI 368


>gi|117938768 GNAS complex locus alex [Homo sapiens]
          Length = 626

 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 28/79 (35%), Positives = 39/79 (49%), Gaps = 6/79 (7%)

Query: 299 QPLRLFP--SPGLPTRTSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKP 356
           QPL+  P  +PG P +  P  G  + + T    +P  TPG+P  P   P P   G P+ P
Sbjct: 332 QPLQPQPILTPGQPQKI-PTPGQHQPILTPGHSQPIPTPGQPLPPQPIPTP---GRPLTP 387

Query: 357 TSLETPSAPLLSRCVSMPG 375
             + TP  PL  + + MPG
Sbjct: 388 QPIPTPGRPLTPQPIQMPG 406



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 43/147 (29%), Positives = 55/147 (37%), Gaps = 34/147 (23%)

Query: 305 PSPGLPTRTSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPG------------PTGD 352
           P+PG P    P+    R +    T +P  TPGRP  P    +PG              G 
Sbjct: 367 PTPGQPLPPQPIPTPGRPL----TPQPIPTPGRPLTPQPIQMPGRPLRLPPPLRLLRPGQ 422

Query: 353 PVKPTSLETPSAPLLSRCVSMPGD-------ISGLQGGP--RSDFDMAYERGRISVSLQE 403
           P+ P   +T   P L + +  PG        +  L  GP  RS  D    R R+ + L  
Sbjct: 423 PMSPQLRQTQGLP-LPQPLLPPGQPKSAGRPLQPLPPGPDARSISDPPAPRSRLPIRLLR 481

Query: 404 EASGGSLAAPARTP-TQEPREQPAGAC 429
               G L   AR P    PR   A AC
Sbjct: 482 ----GLL---ARLPGGASPRAAAAAAC 501


>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
           [Homo sapiens]
          Length = 881

 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 32/120 (26%), Positives = 56/120 (46%), Gaps = 17/120 (14%)

Query: 451 RQTSSIFEAAKQELAKLMRIEDPSLLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLH 510
           +  + +  + K+ELA ++  E            H+KAGT++  QGD+  S + +  G ++
Sbjct: 202 KAVAHLSNSVKRELAAVLLFEP-----------HSKAGTVLFSQGDKGTSWYIIWKGSVN 250

Query: 511 VYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRD-CTFLRISKSDFYEIMR 569
           V            +     G+  GQLA++   P   T+  + D C FLR+ K DF  I++
Sbjct: 251 VVTH-----GKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIK 305



 Score = 34.3 bits (77), Expect = 0.82
 Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 4/62 (6%)

Query: 603 EAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRAT 662
           +AG  L+ QGD+    YI+  G + +V+  G G   LV     GD  G +  +   PRA 
Sbjct: 226 KAGTVLFSQGDKGTSWYIIWKGSV-NVVTHGKG---LVTTLHEGDDFGQLALVNDAPRAA 281

Query: 663 TV 664
           T+
Sbjct: 282 TI 283


>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
           [Homo sapiens]
          Length = 881

 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 32/120 (26%), Positives = 56/120 (46%), Gaps = 17/120 (14%)

Query: 451 RQTSSIFEAAKQELAKLMRIEDPSLLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLH 510
           +  + +  + K+ELA ++  E            H+KAGT++  QGD+  S + +  G ++
Sbjct: 202 KAVAHLSNSVKRELAAVLLFEP-----------HSKAGTVLFSQGDKGTSWYIIWKGSVN 250

Query: 511 VYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRD-CTFLRISKSDFYEIMR 569
           V            +     G+  GQLA++   P   T+  + D C FLR+ K DF  I++
Sbjct: 251 VVTH-----GKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIK 305



 Score = 34.3 bits (77), Expect = 0.82
 Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 4/62 (6%)

Query: 603 EAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRAT 662
           +AG  L+ QGD+    YI+  G + +V+  G G   LV     GD  G +  +   PRA 
Sbjct: 226 KAGTVLFSQGDKGTSWYIIWKGSV-NVVTHGKG---LVTTLHEGDDFGQLALVNDAPRAA 281

Query: 663 TV 664
           T+
Sbjct: 282 TI 283


>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
           [Homo sapiens]
          Length = 923

 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 32/120 (26%), Positives = 56/120 (46%), Gaps = 17/120 (14%)

Query: 451 RQTSSIFEAAKQELAKLMRIEDPSLLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLH 510
           +  + +  + K+ELA ++  E            H+KAGT++  QGD+  S + +  G ++
Sbjct: 244 KAVAHLSNSVKRELAAVLLFEP-----------HSKAGTVLFSQGDKGTSWYIIWKGSVN 292

Query: 511 VYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRD-CTFLRISKSDFYEIMR 569
           V            +     G+  GQLA++   P   T+  + D C FLR+ K DF  I++
Sbjct: 293 VVTH-----GKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIK 347



 Score = 34.3 bits (77), Expect = 0.82
 Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 4/62 (6%)

Query: 603 EAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRAT 662
           +AG  L+ QGD+    YI+  G + +V+  G G   LV     GD  G +  +   PRA 
Sbjct: 268 KAGTVLFSQGDKGTSWYIIWKGSV-NVVTHGKG---LVTTLHEGDDFGQLALVNDAPRAA 323

Query: 663 TV 664
           T+
Sbjct: 324 TI 325


>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
          Length = 664

 Score = 42.4 bits (98), Expect = 0.003
 Identities = 38/147 (25%), Positives = 65/147 (44%), Gaps = 13/147 (8%)

Query: 117 PAVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFR 176
           PA L A++      N HL +     LK VR+    E  L +EL   +  Q    GDY+ R
Sbjct: 433 PAKLRAEIA----INVHLST-----LKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICR 483

Query: 177 PGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVS 236
            G     +Y++++G  +L +   DG       ++   S    +SIL++       +RT +
Sbjct: 484 KGDIGKEMYIIKEG--KLAVVADDG--VTQYALLSAGSCFGEISILNIKGSKMGNRRTAN 539

Query: 237 ARAARDSTVLRLPVEAFSAVFTKYPES 263
            R+   S +  L  +      T+YP++
Sbjct: 540 IRSLGYSDLFCLSKDDLMEAVTEYPDA 566


>gi|33286446 opioid growth factor receptor [Homo sapiens]
          Length = 677

 Score = 41.6 bits (96), Expect = 0.005
 Identities = 39/130 (30%), Positives = 47/130 (36%), Gaps = 11/130 (8%)

Query: 325 TSATDEPRE-TPGRPPDPTGAPLPGPTGDPVKPTSLETPSAPLLSRCVSMPGDISGLQGG 383
           T     P+E TPG P +  G    GP GD    +  ETP           P +      G
Sbjct: 504 TEGRTGPKEGTPGSPSETPGPSPAGPAGDEPAESPSETPGPRPAGPAGDEPAESPSETPG 563

Query: 384 PRSDFDMAYERGRISVSLQEEASGGSLAAPAR-----TPTQEPREQPAGACEYSYCEDES 438
           PR     A   G        E  G S A P R     +P++ P  +PAG       E  S
Sbjct: 564 PRP----AGPAGDEPAESPSETPGPSPAGPTRDEPAESPSETPGPRPAGPAGDEPAESPS 619

Query: 439 AT-GGCPFGP 447
            T G  P GP
Sbjct: 620 ETPGPRPAGP 629



 Score = 36.2 bits (82), Expect = 0.21
 Identities = 23/62 (37%), Positives = 26/62 (41%), Gaps = 7/62 (11%)

Query: 305 PSPGLPTRTSPVRGSKR----MVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLE 360
           PSP  PTR  P            +  A DEP E+P   P P  A   GP GD    +  E
Sbjct: 584 PSPAGPTRDEPAESPSETPGPRPAGPAGDEPAESPSETPGPRPA---GPAGDEPAESPSE 640

Query: 361 TP 362
           TP
Sbjct: 641 TP 642



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 38/147 (25%), Positives = 52/147 (35%), Gaps = 15/147 (10%)

Query: 312 RTSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLP-----GPTGDPVKPTSLET----P 362
           RT P  G+    S +    P    G  P  + +  P     GP GD    +  ET    P
Sbjct: 507 RTGPKEGTPGSPSETPGPSPAGPAGDEPAESPSETPGPRPAGPAGDEPAESPSETPGPRP 566

Query: 363 SAPLLSRCVSMPGDISG-LQGGPRSDFDMAYERGRISVSLQEEASGGSLAAPARTPTQEP 421
           + P        P +  G    GP  D          S +     +G +   PA +P++ P
Sbjct: 567 AGPAGDEPAESPSETPGPSPAGPTRDEPAESP----SETPGPRPAGPAGDEPAESPSETP 622

Query: 422 REQPAGACEYSYCEDESAT-GGCPFGP 447
             +PAG       E  S T G  P GP
Sbjct: 623 GPRPAGPAGDEPAESPSETPGPSPAGP 649



 Score = 32.0 bits (71), Expect = 4.1
 Identities = 42/151 (27%), Positives = 51/151 (33%), Gaps = 22/151 (14%)

Query: 305 PSPGLPTRTSPVRGSKRMVSTSATDEPR------ETPGRPPDPTGAPLP-GPTGDPVKPT 357
           PS     R +   G +   S S T  PR      + P   P  T  P P GPT D    +
Sbjct: 538 PSETPGPRPAGPAGDEPAESPSETPGPRPAGPAGDEPAESPSETPGPSPAGPTRDEPAES 597

Query: 358 SLETPSAPLLSRCVSMPGDISGLQGGPRSDFDMAYERGRISVSLQEEASGGSLAAPARTP 417
             ETP           P +      GPR     A   G        E  G S A P    
Sbjct: 598 PSETPGPRPAGPAGDEPAESPSETPGPRP----AGPAGDEPAESPSETPGPSPAGPT--- 650

Query: 418 TQEPREQPAGACEYSYCED----ESATGGCP 444
               R++PA A E +  +D     SA  G P
Sbjct: 651 ----RDEPAKAGEAAELQDAEVESSAKSGKP 677


>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
           [Homo sapiens]
          Length = 759

 Score = 41.2 bits (95), Expect = 0.007
 Identities = 33/123 (26%), Positives = 58/123 (47%), Gaps = 6/123 (4%)

Query: 142 LKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDG 201
           LK VR+    E  L +EL   +  Q    GDY+ + G     +Y++++G  +L +   DG
Sbjct: 543 LKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEG--KLAVVADDG 600

Query: 202 KECVVKEVVPGD-SVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKY 260
              V + VV  D S    +SIL++       +RT + ++   S +  L  +      T+Y
Sbjct: 601 ---VTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEY 657

Query: 261 PES 263
           P++
Sbjct: 658 PDA 660


>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
           sapiens]
          Length = 690

 Score = 41.2 bits (95), Expect = 0.007
 Identities = 33/123 (26%), Positives = 58/123 (47%), Gaps = 6/123 (4%)

Query: 142 LKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDG 201
           LK VR+    E  L +EL   +  Q    GDY+ + G     +Y++++G  +L +   DG
Sbjct: 474 LKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEG--KLAVVADDG 531

Query: 202 KECVVKEVVPGD-SVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKY 260
              V + VV  D S    +SIL++       +RT + ++   S +  L  +      T+Y
Sbjct: 532 ---VTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEY 588

Query: 261 PES 263
           P++
Sbjct: 589 PDA 591


>gi|4758958 cAMP-dependent protein kinase, regulatory subunit alpha
           2 [Homo sapiens]
          Length = 404

 Score = 41.2 bits (95), Expect = 0.007
 Identities = 69/317 (21%), Positives = 125/317 (39%), Gaps = 28/317 (8%)

Query: 417 PTQEPREQPAGACEYSYCEDESATGGCPFGPYQGRQTSSIFEAAKQELA-KLMRIEDPSL 475
           P++  R     A  Y+  E+E  T      P    Q   + EA K  L  K +  E  S 
Sbjct: 91  PSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQ 150

Query: 476 LNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQ 535
           +   +     KA   +  QGD   + + +  G   +     ++   V  +  +     G+
Sbjct: 151 VLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGS--FGE 208

Query: 536 LAVLTGEPLIFTLRAQRD--------CTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMS 587
           LA++   P   T+ A  +         TF RI   +  +  +   S + S     +  +S
Sbjct: 209 LALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVS 268

Query: 588 PFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNG------RLRSVIQRGSGKKEL-V 640
             ++ +D  I     + G  +  QG+++D  YI+ +G      R R+   +  G +E+ +
Sbjct: 269 ERMKIVD-VIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEI 327

Query: 641 GEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKLP----EGTLGH----IKRRYPQVVT 692
               +G   G +  +T +PRA + +AV D +   +     E  LG     +KR       
Sbjct: 328 ARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEE 387

Query: 693 RLIHLLSQKI-LGNLQQ 708
           +L+ +    + LGNL Q
Sbjct: 388 QLVKMFGSSVDLGNLGQ 404


>gi|116256354 alpha 2 type IV collagen preproprotein [Homo sapiens]
          Length = 1712

 Score = 40.8 bits (94), Expect = 0.009
 Identities = 32/98 (32%), Positives = 36/98 (36%), Gaps = 18/98 (18%)

Query: 305 PSPGLPTRTSPVRGSKRMVSTSATDEPRETPGRP-----PDPTG----------APLPGP 349
           P P  PT    +RG            PR  PG       P P G            LPGP
Sbjct: 692 PGPPGPTGAKGLRGIPGFAGADGGPGPRGLPGDAGREGFPGPPGFIGPRGSKGAVGLPGP 751

Query: 350 TGDPVKPTSLETPSAPLLSRCVSMPGDISGLQGGPRSD 387
            G P  P  L  P  P   R   +PG++ G Q GPR D
Sbjct: 752 DGSP-GPIGLPGPDGPPGER--GLPGEVLGAQPGPRGD 786


>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
           [Homo sapiens]
          Length = 676

 Score = 40.4 bits (93), Expect = 0.011
 Identities = 34/123 (27%), Positives = 56/123 (45%), Gaps = 6/123 (4%)

Query: 142 LKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDG 201
           LK VR+    E  L +EL   +       GDY+ + G     +Y++ +G  +L +   DG
Sbjct: 459 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEG--KLAVVADDG 516

Query: 202 KECVVKEVVPGD-SVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKY 260
              V + VV  D S    +SIL++       +RT + R+   S +  L  +      T+Y
Sbjct: 517 ---VTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEY 573

Query: 261 PES 263
           PE+
Sbjct: 574 PEA 576


>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
           sapiens]
          Length = 694

 Score = 40.4 bits (93), Expect = 0.011
 Identities = 34/123 (27%), Positives = 56/123 (45%), Gaps = 6/123 (4%)

Query: 142 LKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDG 201
           LK VR+    E  L +EL   +       GDY+ + G     +Y++ +G  +L +   DG
Sbjct: 477 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEG--KLAVVADDG 534

Query: 202 KECVVKEVVPGD-SVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKY 260
              V + VV  D S    +SIL++       +RT + R+   S +  L  +      T+Y
Sbjct: 535 ---VTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEY 591

Query: 261 PES 263
           PE+
Sbjct: 592 PEA 594


>gi|72004269 tetra-peptide repeat homeobox [Homo sapiens]
          Length = 411

 Score = 40.0 bits (92), Expect = 0.015
 Identities = 30/89 (33%), Positives = 40/89 (44%), Gaps = 7/89 (7%)

Query: 300 PLRLFPSPG-LPTRTSPVRGSKRMVSTSATDEPRETPG--RPPDPTGAPLPGPTGDPVK- 355
           P  L P PG +P   +P+ G  ++        P   PG  + P P  AP+PGP   PV+ 
Sbjct: 89  PAALSPGPGPIP---APIPGPAQIPGPLPGSIPGPIPGPAQIPSPIPAPIPGPISGPVQI 145

Query: 356 PTSLETPSAPLLSRCVSMPGDISGLQGGP 384
           P     P    +S    +PG ISG   GP
Sbjct: 146 PGPFRGPIPGPISGPAPIPGPISGPFSGP 174



 Score = 34.7 bits (78), Expect = 0.63
 Identities = 36/126 (28%), Positives = 48/126 (38%), Gaps = 10/126 (7%)

Query: 305 PSPGLPTRTSPVRG--SKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLETP 362
           P PG  +  +P+ G  S      +    P   PG  P P   P+PGP   P+ P  +  P
Sbjct: 152 PIPGPISGPAPIPGPISGPFSGPNPGPIPGPNPGPIPGPISGPIPGPISVPI-PGPIPGP 210

Query: 363 -SAPLLSRCVS-----MPGDISGLQGGPRSDFDMAYERGRISVSLQEEASG-GSLAAPAR 415
            S P+           +PG ISG   GP          G I   +    SG G +  P  
Sbjct: 211 ISGPISGPNPGPIPGPIPGPISGPNPGPIPGPISGPNPGLIPGPIPGPISGPGPIIGPIP 270

Query: 416 TPTQEP 421
           +P Q P
Sbjct: 271 SPAQIP 276


>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
            sapiens]
          Length = 1251

 Score = 39.7 bits (91), Expect = 0.019
 Identities = 34/117 (29%), Positives = 56/117 (47%), Gaps = 14/117 (11%)

Query: 155  LFLELCRHMVFQRLGQ--------GDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVV 206
            LF    R M+F  L +         DYV + G+    +Y++Q G +++ L GPDGK  +V
Sbjct: 962  LFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQV-LGGPDGKSVLV 1020

Query: 207  KEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPES 263
               +   SV   +S+L V  G+   +RT +  A   + +  L  +  + +   YPES
Sbjct: 1021 --TLKAGSVFGEISLLAVGGGN---RRTANVVAHGFTNLFILDKKDLNEILVHYPES 1072


>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
          Length = 668

 Score = 38.9 bits (89), Expect = 0.033
 Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 3/52 (5%)

Query: 312 RTSPVRGSKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLETPS 363
           R+  + G+   +STS    PR TP   P P G+PLP P G PV  T  E+P+
Sbjct: 409 RSRSISGASSGLSTSPLSSPRVTPH--PSPRGSPLPTPKGTPVH-TPKESPA 457


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score = 38.1 bits (87), Expect = 0.057
 Identities = 56/250 (22%), Positives = 91/250 (36%), Gaps = 52/250 (20%)

Query: 165 FQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDV 224
           F+    GDY+ R G     +Y +Q G++ +   G        KE+   D   S    + +
Sbjct: 562 FEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGN-------KEMKLSDG--SYFGEICL 612

Query: 225 ITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRV---TFL 281
           +T     +RT S RA     +  L V+ F+ V  +YP        + + RL R+     +
Sbjct: 613 LT---RGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSI 669

Query: 282 ALHNYL-GLTNELFSHEI---------------------QPLRLFPSPGLPTRTSPV--- 316
            LH     L + +F+++                      Q + LFP P  P + +     
Sbjct: 670 LLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPPPQVTSAIAT 729

Query: 317 -----------RGSKRMVSTSATDEPRETPGRPPDPT-GAPLPGPTGDPVKPTSLETPSA 364
                      + ++ +V   A   PR     PP P   A  PGP      P +  +P A
Sbjct: 730 LQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPPASPPGAPASPRA 789

Query: 365 PLLSRCVSMP 374
           P  S    +P
Sbjct: 790 PRTSPYGGLP 799



 Score = 31.2 bits (69), Expect = 6.9
 Identities = 34/124 (27%), Positives = 46/124 (37%), Gaps = 9/124 (7%)

Query: 331 PRETPGRPPDPTGAPLPGPTGDPVKPTSLETPSAPLLSRCVSMPGDISGLQGGPRSDFDM 390
           P E+PG  P P G P P P   P +      P AP      + P      +  P    D 
Sbjct: 10  PGESPGATPAP-GPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEALPPEAADE 68

Query: 391 AYERGRISVSLQEEASGGSLAAPARTPTQEPREQPAGACEYSYCEDESATGGCPFGPYQG 450
              RGR+      ++S G    P    T   +  P G C     E + +  G P GP +G
Sbjct: 69  GGPRGRLR---SRDSSCGRPGTPGAAST--AKGSPNGECGRG--EPQCSPAG-PEGPARG 120

Query: 451 RQTS 454
            + S
Sbjct: 121 PKVS 124


>gi|145309322 insulinoma-associated protein IA-6 [Homo sapiens]
          Length = 566

 Score = 38.1 bits (87), Expect = 0.057
 Identities = 36/133 (27%), Positives = 43/133 (32%), Gaps = 25/133 (18%)

Query: 310 PTRTSPVRGSKRMVSTSATDEPRETPGRPPDPTG--------------APLPGPTGDPVK 355
           PTR  P +G     +   +  P    G  P   G               P P P+  P K
Sbjct: 55  PTREEPGKGLTAEAAREQSGSPCRAAGVSPGTGGREGAEWRAGGREGPGPSPSPSPSPAK 114

Query: 356 PTSLETPSAPLLSRCVSMPGDISGLQGGPRSDFDMAYERGRISVSLQEEAS---GGSLAA 412
           P   E   A  L RC+S P       GG       A      S S+   A+   G     
Sbjct: 115 PAGAELRRA-FLERCLSSPVSAESFPGG-------AAAVAAFSCSVAPAAAPTPGEQFLL 166

Query: 413 PARTPTQEPREQP 425
           P R P  EP  QP
Sbjct: 167 PLRAPFPEPALQP 179


>gi|24431935 reticulon 4 isoform A [Homo sapiens]
          Length = 1192

 Score = 37.4 bits (85), Expect = 0.096
 Identities = 46/183 (25%), Positives = 66/183 (36%), Gaps = 22/183 (12%)

Query: 305 PSPGLPTRTSPVRGSKRMVSTSATDEPRETPGRPPDPTGA---PLPGPTGDPVKPTSLET 361
           PSP   T  +P   S   VS S   E  E P RPP P  A   P   P   P  P     
Sbjct: 110 PSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAP 169

Query: 362 PSAPLLSR-----------CVSMPGDISGLQGGPRSDFDMAYERGRISVSLQEEASGGSL 410
           PS P   +             ++P     +      + D+  + G    + QE+     L
Sbjct: 170 PSTPAAPKRRGSSGSVDETLFALPAASEPVIRSSAENMDLKEQPGNTISAGQEDFPSVLL 229

Query: 411 AAPARTPTQEPREQPAGACEYSYCEDESATGGCPFGPYQGRQTSSIFEAAKQ--ELAKLM 468
              A  P+  P    A   E+ Y  + S        P +G    ++ EA+K+  E AK +
Sbjct: 230 ETAASLPSLSPL-SAASFKEHEYLGNLSTV-----LPTEGTLQENVSEASKEVSEKAKTL 283

Query: 469 RIE 471
            I+
Sbjct: 284 LID 286


>gi|197245373 proline rich 22 isoform 1 [Homo sapiens]
          Length = 422

 Score = 37.0 bits (84), Expect = 0.13
 Identities = 58/260 (22%), Positives = 87/260 (33%), Gaps = 44/260 (16%)

Query: 108 PTLQRKEPPPAV--LEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLEL-CRHMV 164
           P  +  +PPP +  L A+ T    A SHL             LGHF  P  L    + + 
Sbjct: 186 PPPKENKPPPVLITLPAEPTLPPDAYSHLQGH----------LGHFPGPEPLAFPVKELQ 235

Query: 165 FQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDV 224
                 G  ++ PG  +  +  V++G L         K      +     +   + + D 
Sbjct: 236 GSGARPGVPLYPPGLSELKVAEVKEGALLGAGKAKAPKTARALALPDKVLLEDAMKLFDC 295

Query: 225 ITGHQHPQRTV------------SARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIM 272
           + G   P+ T+               +A D   L LP E  S  ++  PE L  V  +  
Sbjct: 296 LPGASEPEGTLCEVPGPALPDSSGGNSADDIRSLCLPEELLSFDYS-VPEILDTVSNVDY 354

Query: 273 VRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRTSPVRGSKRMVSTSATDEPR 332
                       N+  L  E   H        P P      +P+   KR  ST+   +P 
Sbjct: 355 ----------FFNFKALDEEQPPH--------PGPPATNTPAPILSGKRKASTAKKGKPG 396

Query: 333 ETPGRPPDPTGAPLPGPTGD 352
               +P  P  A  PGP  D
Sbjct: 397 RKARQPAGPASATPPGPRED 416


>gi|23503299 proline rich 22 isoform 2 [Homo sapiens]
          Length = 420

 Score = 37.0 bits (84), Expect = 0.13
 Identities = 58/260 (22%), Positives = 87/260 (33%), Gaps = 44/260 (16%)

Query: 108 PTLQRKEPPPAV--LEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLEL-CRHMV 164
           P  +  +PPP +  L A+ T    A SHL             LGHF  P  L    + + 
Sbjct: 184 PPPKENKPPPVLITLPAEPTLPPDAYSHLQGH----------LGHFPGPEPLAFPVKELQ 233

Query: 165 FQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDV 224
                 G  ++ PG  +  +  V++G L         K      +     +   + + D 
Sbjct: 234 GSGARPGVPLYPPGLSELKVAEVKEGALLGAGKAKAPKTARALALPDKVLLEDAMKLFDC 293

Query: 225 ITGHQHPQRTV------------SARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIM 272
           + G   P+ T+               +A D   L LP E  S  ++  PE L  V  +  
Sbjct: 294 LPGASEPEGTLCEVPGPALPDSSGGNSADDIRSLCLPEELLSFDYS-VPEILDTVSNVDY 352

Query: 273 VRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRTSPVRGSKRMVSTSATDEPR 332
                       N+  L  E   H        P P      +P+   KR  ST+   +P 
Sbjct: 353 ----------FFNFKALDEEQPPH--------PGPPATNTPAPILSGKRKASTAKKGKPG 394

Query: 333 ETPGRPPDPTGAPLPGPTGD 352
               +P  P  A  PGP  D
Sbjct: 395 RKARQPAGPASATPPGPRED 414


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,892,384
Number of Sequences: 37866
Number of extensions: 2682292
Number of successful extensions: 13380
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 257
Number of HSP's that attempted gapping in prelim test: 11713
Number of HSP's gapped (non-prelim): 1781
length of query: 1327
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1213
effective length of database: 13,930,794
effective search space: 16898053122
effective search space used: 16898053122
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.