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Search of human proteins with 238814322
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
(923 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 1849 0.0
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 1412 0.0
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 470 e-132
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 467 e-131
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 465 e-131
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 464 e-130
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 457 e-128
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 425 e-119
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 409 e-114
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 343 4e-94
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 318 2e-86
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 269 8e-72
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 260 5e-69
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 251 2e-66
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 214 2e-55
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 188 2e-47
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 155 2e-37
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 143 6e-34
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 143 6e-34
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 143 6e-34
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 139 1e-32
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 139 1e-32
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 135 2e-31
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 135 2e-31
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 135 2e-31
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 120 4e-27
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 120 4e-27
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 120 4e-27
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens] 120 4e-27
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 119 1e-26
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 1849 bits (4790), Expect = 0.0
Identities = 923/923 (100%), Positives = 923/923 (100%)
Query: 1 MLRRGSQALRRFSTGRVYFKNKLKLALIGQSLFGQEVYSHLRKEGHRVVGVFTVPDKDGK 60
MLRRGSQALRRFSTGRVYFKNKLKLALIGQSLFGQEVYSHLRKEGHRVVGVFTVPDKDGK
Sbjct: 1 MLRRGSQALRRFSTGRVYFKNKLKLALIGQSLFGQEVYSHLRKEGHRVVGVFTVPDKDGK 60
Query: 61 ADPLALAAEKDGTPVFKLPKWRVKGKTIKEVAEAYRSVGAELNVLPFCTQFIPMDIIDSP 120
ADPLALAAEKDGTPVFKLPKWRVKGKTIKEVAEAYRSVGAELNVLPFCTQFIPMDIIDSP
Sbjct: 61 ADPLALAAEKDGTPVFKLPKWRVKGKTIKEVAEAYRSVGAELNVLPFCTQFIPMDIIDSP 120
Query: 121 KHGSIIYHPSILPRHRGASAINWTLIMGDKKAGFSVFWADDGLDTGPILLQRSCDVEPND 180
KHGSIIYHPSILPRHRGASAINWTLIMGDKKAGFSVFWADDGLDTGPILLQRSCDVEPND
Sbjct: 121 KHGSIIYHPSILPRHRGASAINWTLIMGDKKAGFSVFWADDGLDTGPILLQRSCDVEPND 180
Query: 181 TVDALYNRFLFPEGIKAMVEAVQLIADGKAPRIPQPEEGATYEGIQKKENAEISWDQSAE 240
TVDALYNRFLFPEGIKAMVEAVQLIADGKAPRIPQPEEGATYEGIQKKENAEISWDQSAE
Sbjct: 181 TVDALYNRFLFPEGIKAMVEAVQLIADGKAPRIPQPEEGATYEGIQKKENAEISWDQSAE 240
Query: 241 VLHNWIRGHDKVPGAWTEINGQMVTFYGSTLLNSSVPPGEPLEIKGAKKPGLVTKNGLVL 300
VLHNWIRGHDKVPGAWTEINGQMVTFYGSTLLNSSVPPGEPLEIKGAKKPGLVTKNGLVL
Sbjct: 241 VLHNWIRGHDKVPGAWTEINGQMVTFYGSTLLNSSVPPGEPLEIKGAKKPGLVTKNGLVL 300
Query: 301 FGNDGKALTVRNLQFEDGKMIPASQYFSTGETSVVELTAEEVKVAETIKVIWAGILSNVP 360
FGNDGKALTVRNLQFEDGKMIPASQYFSTGETSVVELTAEEVKVAETIKVIWAGILSNVP
Sbjct: 301 FGNDGKALTVRNLQFEDGKMIPASQYFSTGETSVVELTAEEVKVAETIKVIWAGILSNVP 360
Query: 361 IIEDSTDFFKSGASSMDVARLVEEIRQKCGGLQLQNEDVYMATKFEGFIQKVVRKLRGED 420
IIEDSTDFFKSGASSMDVARLVEEIRQKCGGLQLQNEDVYMATKFEGFIQKVVRKLRGED
Sbjct: 361 IIEDSTDFFKSGASSMDVARLVEEIRQKCGGLQLQNEDVYMATKFEGFIQKVVRKLRGED 420
Query: 421 QEVELVVDYISKEVNEIMVKMPYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLA 480
QEVELVVDYISKEVNEIMVKMPYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLA
Sbjct: 421 QEVELVVDYISKEVNEIMVKMPYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLA 480
Query: 481 DVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLAL 540
DVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLAL
Sbjct: 481 DVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLAL 540
Query: 541 KTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMM 600
KTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMM
Sbjct: 541 KTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMM 600
Query: 601 LAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSE 660
LAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSE
Sbjct: 601 LAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSE 660
Query: 661 HPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAV 720
HPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAV
Sbjct: 661 HPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAV 720
Query: 721 FFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLL 780
FFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLL
Sbjct: 721 FFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLL 780
Query: 781 QYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGD 840
QYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGD
Sbjct: 781 QYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGD 840
Query: 841 IDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSG 900
IDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSG
Sbjct: 841 IDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSG 900
Query: 901 FGKDLGEEALNEYLKTKTVTLEY 923
FGKDLGEEALNEYLKTKTVTLEY
Sbjct: 901 FGKDLGEEALNEYLKTKTVTLEY 923
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 1412 bits (3654), Expect = 0.0
Identities = 669/902 (74%), Positives = 789/902 (87%), Gaps = 1/902 (0%)
Query: 23 LKLALIGQSLFGQEVYSHLRKEGHRVVGVFTVPDKDGKADPLALAAEKDGTPVFKLPKWR 82
+K+A+IGQSLFGQEVY HLRKEGH VVGVFTVPDKDGKADPL L AEKDG PVFK +WR
Sbjct: 1 MKIAVIGQSLFGQEVYCHLRKEGHEVVGVFTVPDKDGKADPLGLEAEKDGVPVFKYSRWR 60
Query: 83 VKGKTIKEVAEAYRSVGAELNVLPFCTQFIPMDIIDSPKHGSIIYHPSILPRHRGASAIN 142
KG+ + +V Y+++GAELNVLPFC+QFIPM+II +P+HGSIIYHPS+LPRHRGASAIN
Sbjct: 61 AKGQALPDVVAKYQALGAELNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGASAIN 120
Query: 143 WTLIMGDKKAGFSVFWADDGLDTGPILLQRSCDVEPNDTVDALYNRFLFPEGIKAMVEAV 202
WTLI GDKK GFS+FWADDGLDTG +LLQ+ C+V P+DTV LYNRFLFPEGIK MV+AV
Sbjct: 121 WTLIHGDKKGGFSIFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAV 180
Query: 203 QLIADGKAPRIPQPEEGATYEGIQKKENAEISWDQSAEVLHNWIRGHDKVPGAWTEINGQ 262
+LIA+GKAPR+PQPEEGATYEGIQKKE A+I+WDQ AE +HNWIRG+DKVPGAWTE Q
Sbjct: 181 RLIAEGKAPRLPQPEEGATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEACEQ 240
Query: 263 MVTFYGSTLLNSS-VPPGEPLEIKGAKKPGLVTKNGLVLFGNDGKALTVRNLQFEDGKMI 321
+TF+ STL S VP G+ L I GA +PG+VTK GL+LFGND K L V+N+Q EDGKMI
Sbjct: 241 KLTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTKAGLILFGNDDKMLLVKNIQLEDGKMI 300
Query: 322 PASQYFSTGETSVVELTAEEVKVAETIKVIWAGILSNVPIIEDSTDFFKSGASSMDVARL 381
AS +F +SV+ELT E+ AE ++ +W IL V +EDSTDFFKSGA+S+DV RL
Sbjct: 301 LASNFFKGAASSVLELTEAELVTAEAVRSVWQRILPKVLEVEDSTDFFKSGAASVDVVRL 360
Query: 382 VEEIRQKCGGLQLQNEDVYMATKFEGFIQKVVRKLRGEDQEVELVVDYISKEVNEIMVKM 441
VEE+++ C GL+L+NEDVYMA+ F FIQ +VRKLRG+D+E E +DY+ VN+ V+M
Sbjct: 361 VEEVKELCDGLELENEDVYMASTFGDFIQLLVRKLRGDDEEGECSIDYVEMAVNKRTVRM 420
Query: 442 PYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRM 501
P+Q FI G+F DA+ KT +TINPTDGS IC+VS A + DVDKAVAAAKDAFENG WG++
Sbjct: 421 PHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKI 480
Query: 502 NARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKI 561
+AR+RGRLMYRLADL+E++QEELATIEALD+GAVYTLALKTH+GMS+QTFRYFAGWCDKI
Sbjct: 481 SARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKI 540
Query: 562 QGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQ 621
QGSTIPINQARPNRNLT T+KEP+GVC IIIPWNYPLMML+WK+AACLAAGNT+V+KPAQ
Sbjct: 541 QGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQ 600
Query: 622 VTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMK 681
VTPLTALKFAEL++KAG PKGV+N++PGSG + GQRLS+HPD+RK+GFTGST +GK IMK
Sbjct: 601 VTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMK 660
Query: 682 SCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIH 741
SCA+SN+KKVSLELGGKSPLIIF DC+L+KAV+MGM +VFFNKGENCIAAGRLFVE+SIH
Sbjct: 661 SCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIH 720
Query: 742 DEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQ 801
DEFV RVVEE++KMK+G+PLDR TDHGPQNH AHL KL++YC+ GVKEGATLV GG QV
Sbjct: 721 DEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVP 780
Query: 802 RPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFT 861
RPGFF EPTVFTDVED+M++AKEESFGP+M+IS+F +GD+D VL RAN+TE+GLASGVFT
Sbjct: 781 RPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFT 840
Query: 862 RDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTL 921
RDINKA+YVS+KL+AGTVF+NTYNKTDVAAPFGG KQSGFGKDLGE ALNEYL+ KTVT
Sbjct: 841 RDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTF 900
Query: 922 EY 923
EY
Sbjct: 901 EY 902
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 470 bits (1210), Expect = e-132
Identities = 238/478 (49%), Positives = 326/478 (68%), Gaps = 7/478 (1%)
Query: 446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGE-WGRMNAR 504
FIN ++ +++ G+ + NP G +C+V A AD+DKAV AA+ AF G W RM+A
Sbjct: 41 FINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDAS 100
Query: 505 ERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGS 564
ERGRL+ +LADL+E ++ LAT+E+L+ G + A + ++TFRY+AGW DKI G
Sbjct: 101 ERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGM 160
Query: 565 TIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTP 624
TIP++ TFT+ EP+GVC IIPWN+PL+M AWK A L GNT+V+KPA+ TP
Sbjct: 161 TIPVD----GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 216
Query: 625 LTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCA 684
L+AL L +AGFP GVINI+PG G AG ++ H I K+ FTGST +GK I ++
Sbjct: 217 LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 276
Query: 685 VSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEF 744
SNLK+V+LELGGKSP IIF D +LD AV VFFN+G+ C A R+FVEESI++EF
Sbjct: 277 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 336
Query: 745 VTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPG 804
V R VE K+ +G P D +T+ GPQ K K+L+ ++GV EGA L GG+ + R G
Sbjct: 337 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 396
Query: 805 FFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDI 864
FF+EPTVF++V D M +AKEE FGP+ I +F+ +D V++RAN++++GL + VFT DI
Sbjct: 397 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKT--MDEVIERANNSDFGLVAAVFTNDI 454
Query: 865 NKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTLE 922
NKA+ VS ++AGTV+IN YN + +PFGG K SG G+++GE L EY + KTVT++
Sbjct: 455 NKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 512
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 467 bits (1201), Expect = e-131
Identities = 240/486 (49%), Positives = 327/486 (67%), Gaps = 8/486 (1%)
Query: 439 VKMPY-QCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGE 497
+K+ Y + FIN ++ D+ GK + NP +C+V DVDKAV AA+ AF+ G
Sbjct: 16 LKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGS 75
Query: 498 -WGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAG 556
W M+A ERGRL+Y+LADL+E ++ LAT+E+++ G +Y+ A + ++T RY AG
Sbjct: 76 PWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAG 135
Query: 557 WCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLV 616
W DKIQG TIPI+ T+T+ EP+GVC IIPWN+PL+ML WK L+ GNT+V
Sbjct: 136 WADKIQGRTIPID----GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVV 191
Query: 617 LKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIG 676
+KPA+ TPLTAL A L +AGFP GV+NI+PG G AG +S H DI K+ FTGST +G
Sbjct: 192 VKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVG 251
Query: 677 KQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFV 736
K I ++ SNLK+V+LELGGKSP I+ D +LD AV VF+++G+ CIAA R+FV
Sbjct: 252 KLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFV 311
Query: 737 EESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYG 796
EESI+DEFV R VE KK +G+PL GPQ K +K+L E+G KEGA L G
Sbjct: 312 EESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECG 371
Query: 797 GRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLA 856
G G+F++PTVF++V D M +AKEE FGP+ I KF++ +D V++RAN+T YGL+
Sbjct: 372 GGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKS--LDDVIKRANNTFYGLS 429
Query: 857 SGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKT 916
+GVFT+DI+KA+ +S L+AGTV++N Y PFGG K SG G++LGE +EY +
Sbjct: 430 AGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEV 489
Query: 917 KTVTLE 922
KTVT++
Sbjct: 490 KTVTVK 495
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 465 bits (1197), Expect = e-131
Identities = 238/484 (49%), Positives = 329/484 (67%), Gaps = 8/484 (1%)
Query: 441 MPY-QCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGE-W 498
+PY Q FIN ++ DA KT+ T+NPT G I V+ ADVD+AV AA++AF G W
Sbjct: 34 IPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPW 93
Query: 499 GRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWC 558
RM+A ERGRL+ RLADL+E ++ LA++E LD+G + + + ++ +RYFAGW
Sbjct: 94 RRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWA 153
Query: 559 DKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLK 618
DK G TIP++ ++ FT+ EP+GVC IIPWN+PL+M WK A LA GNT+V+K
Sbjct: 154 DKWHGKTIPMD----GQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMK 209
Query: 619 PAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQ 678
A+ TPL+AL A L +AGFP GV+NII G G AG +++H D+ K+ FTGST +G
Sbjct: 210 VAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHL 269
Query: 679 IMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEE 738
I K+ SNLK+V+LELGGKSP I+ D +++ AV A+FFN G+ C A R FVEE
Sbjct: 270 IQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEE 329
Query: 739 SIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGR 798
SI++EF+ R VE+ K+ K+G+P + T GPQ K E++L Y + G KEGA L+ GG
Sbjct: 330 SIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGE 389
Query: 799 QVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASG 858
+ GFF++PTVF V+D M +AKEE FGP+ + KF+ I+ V++RAN+T YGLA+
Sbjct: 390 RFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKK--IEEVVERANNTRYGLAAA 447
Query: 859 VFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKT 918
VFTRD++KAMY ++ L+AGTV++NTYN PFGG K+SG G++LGE+ L Y + KT
Sbjct: 448 VFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKT 507
Query: 919 VTLE 922
VT++
Sbjct: 508 VTIK 511
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 464 bits (1195), Expect = e-130
Identities = 236/494 (47%), Positives = 330/494 (66%), Gaps = 8/494 (1%)
Query: 430 ISKEVNEIMVKMPYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAA 489
+ + + + VK + FIN ++ ++ GK + T NP+ IC+V DVDKAV AA
Sbjct: 20 LPRPIRNLEVKFT-KIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAA 78
Query: 490 KDAFENGE-WGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSV 548
+ AF+ G W R++A RGRL+++LADL+E ++ LA +E +D+G + A + +
Sbjct: 79 QVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCI 138
Query: 549 QTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAAC 608
+T RYFAGW DKIQG TIP + + + FT+ EP+GVC I PWN+PL+ML WK A
Sbjct: 139 RTLRYFAGWADKIQGKTIPTD----DNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPA 194
Query: 609 LAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLG 668
L GNT+VLKPA+ TPLTAL L +AGFP GV+NI+PG G G +S HP I K+
Sbjct: 195 LCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIA 254
Query: 669 FTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENC 728
FTGST +GK + ++ + SNLK+V+LELGGK+P I+ D +LD AV VFFN+G+ C
Sbjct: 255 FTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCC 314
Query: 729 IAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVK 788
AA R+FVEE ++ EFV R VE KK +GDP D T+ GPQ + +K+L+ E+G K
Sbjct: 315 TAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKK 374
Query: 789 EGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRA 848
EGA L GG ++ G F++PTVF++V D M +AKEE FGP+ I KF++ I+ V++RA
Sbjct: 375 EGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKS--IEEVIKRA 432
Query: 849 NSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEE 908
NST+YGL + VFT++++KA+ ++ LE+GTV+IN YN APFGG K SG G++LGE
Sbjct: 433 NSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEY 492
Query: 909 ALNEYLKTKTVTLE 922
AL EY + KTVT++
Sbjct: 493 ALAEYTEVKTVTIK 506
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 457 bits (1177), Expect = e-128
Identities = 234/480 (48%), Positives = 320/480 (66%), Gaps = 7/480 (1%)
Query: 444 QCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGE-WGRMN 502
Q FIN ++ DA KT+ T+NP+ G IC+V+ DVDKAV AA+ AF+ G W RM+
Sbjct: 38 QIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMD 97
Query: 503 ARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQ 562
A RGRL+ RLADL+E ++ LA +E LD+G Y ++ + M ++ RY+AGW DK
Sbjct: 98 ASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYH 157
Query: 563 GSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQV 622
G TIPI+ ++T+ EP+GVC IIPWN+PL+M AWK LA GN +V+K A+
Sbjct: 158 GKTIPID----GDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQ 213
Query: 623 TPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKS 682
TPLTAL A L +AGFP GV+NI+PG G AG ++ H D+ K+ FTGST IG+ I +
Sbjct: 214 TPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVA 273
Query: 683 CAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHD 742
SNLK+V+LELGGKSP II +D ++D AV A+FFN+G+ C A R FV+E I+D
Sbjct: 274 AGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYD 333
Query: 743 EFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQR 802
EFV R V K +G+P D T+ GPQ + +K+L Y TG +EGA L+ GG
Sbjct: 334 EFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAAD 393
Query: 803 PGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTR 862
G+F++PTVF DV+D M +AKEE FGP+M I KF+ I+ V+ RAN++ YGLA+ VFT+
Sbjct: 394 RGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKT--IEEVVGRANNSTYGLAAAVFTK 451
Query: 863 DINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTLE 922
D++KA Y+S+ L+AGTV++N Y+ +PFGG K SG G++LGE L Y + KTVT++
Sbjct: 452 DLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVK 511
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 425 bits (1093), Expect = e-119
Identities = 215/422 (50%), Positives = 292/422 (69%), Gaps = 6/422 (1%)
Query: 501 MNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDK 560
M+A ERGRL+ +LADL+E ++ LAT+E+L+ G + A + ++TFRY+AGW DK
Sbjct: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 60
Query: 561 IQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPA 620
I G TIP++ TFT+ EP+GVC IIPWN+PL+M AWK A L GNT+V+KPA
Sbjct: 61 IHGMTIPVD----GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPA 116
Query: 621 QVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIM 680
+ TPL+AL L +AGFP GVINI+PG G AG ++ H I K+ FTGST +GK I
Sbjct: 117 EQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQ 176
Query: 681 KSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESI 740
++ SNLK+V+LELGGKSP IIF D +LD AV VFFN+G+ C A R+FVEESI
Sbjct: 177 EAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESI 236
Query: 741 HDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQV 800
++EFV R VE K+ +G P D +T+ GPQ K K+L+ ++GV EGA L GG+ +
Sbjct: 237 YEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGL 296
Query: 801 QRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVF 860
R GFF+EPTVF++V D M +AKEE FGP+ I +F+ +D V++RAN++++GL + VF
Sbjct: 297 GRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKT--MDEVIERANNSDFGLVAAVF 354
Query: 861 TRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVT 920
T DINKA+ VS ++AGTV+IN YN + +PFGG K SG G+++GE L EY + KTVT
Sbjct: 355 TNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVT 414
Query: 921 LE 922
++
Sbjct: 415 VK 416
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 409 bits (1050), Expect = e-114
Identities = 216/478 (45%), Positives = 300/478 (62%), Gaps = 45/478 (9%)
Query: 446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGE-WGRMNAR 504
FIN ++ +++ G+ + NP G +C+V A AD+DKAV AA+ AF G W RM+A
Sbjct: 41 FINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDAS 100
Query: 505 ERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGS 564
ERGRL+ +LADL+E ++ LAT+E+L+ G + A + ++TFRY+AGW DKI G
Sbjct: 101 ERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGM 160
Query: 565 TIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTP 624
TIP++ TFT+ EP+GVC IIPWN+PL+M AWK A L GNT+V+KPA+ TP
Sbjct: 161 TIPVD----GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 216
Query: 625 LTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCA 684
L+AL L + +GK I ++
Sbjct: 217 LSALYMGALIKE--------------------------------------VGKLIQEAAG 238
Query: 685 VSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEF 744
SNLK+V+LELGGKSP IIF D +LD AV VFFN+G+ C A R+FVEESI++EF
Sbjct: 239 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 298
Query: 745 VTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPG 804
V R VE K+ +G P D +T+ GPQ K K+L+ ++GV EGA L GG+ + R G
Sbjct: 299 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 358
Query: 805 FFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDI 864
FF+EPTVF++V D M +AKEE FGP+ I +F+ +D V++RAN++++GL + VFT DI
Sbjct: 359 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKT--MDEVIERANNSDFGLVAAVFTNDI 416
Query: 865 NKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTLE 922
NKA+ VS ++AGTV+IN YN + +PFGG K SG G+++GE L EY + KTVT++
Sbjct: 417 NKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 474
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 343 bits (880), Expect = 4e-94
Identities = 192/475 (40%), Positives = 282/475 (59%), Gaps = 17/475 (3%)
Query: 454 ADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARERGRLMYRL 513
AD T P G I + + +V+ AV AK AF+ W + + ER R++
Sbjct: 47 ADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI--WSQKSGMERCRILLEA 104
Query: 514 ADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARP 573
A ++ E ++E+AT+E +++G A + I +S Q Y+AG + G I + P
Sbjct: 105 ARIIREREDEIATMECINNGKSIFEA-RLDIDISWQCLEYYAGLAASMAGEHIQL----P 159
Query: 574 NRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAEL 633
+ +T++EPLGVC I WNYP + +WKSA LA GN +V KP+ TP++AL AE+
Sbjct: 160 GGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEI 219
Query: 634 SVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSL 693
+AG P G+ N++ G G GQ L +HPD+ K+ FTGS P G +IM+ A +K V+L
Sbjct: 220 YSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSA-KGIKPVTL 277
Query: 694 ELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIK 753
ELGGKSPLIIF+DC+++ AV+ + A F +G+ C R+FV++ I D+F VV++ +
Sbjct: 278 ELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQ 337
Query: 754 KMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGG------RQVQRPGFFM 807
++KIGDPL T GP ++ HLE++L + + ++GA ++ GG + G++M
Sbjct: 338 RIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYM 397
Query: 808 EPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDINKA 867
P V T+ D M KEE FGP+M I F VL+RAN T +GLA+GVFTRDI +A
Sbjct: 398 RPCVLTNCRDDMTCVKEEIFGPVMSILSFDTE--AEVLERANDTTFGLAAGVFTRDIQRA 455
Query: 868 MYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTLE 922
V +L+AGT FIN YN + V PFGG K+SGFG++ G + Y + KTV +E
Sbjct: 456 HRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 510
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 318 bits (814), Expect = 2e-86
Identities = 178/486 (36%), Positives = 285/486 (58%), Gaps = 19/486 (3%)
Query: 446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARE 505
FI+G+F D+ +P+ G C+V + +++ AV AA++AF + W + +E
Sbjct: 13 FIDGKFLPCSS--YIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS--WSSRSPQE 68
Query: 506 RGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGST 565
R R++ ++ADLLE++ EE A E+ D G LA I SVQ FR+FA T
Sbjct: 69 RSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFAS---SSLHHT 125
Query: 566 IPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPL 625
Q + +T + P+GV +I PWN PL +L WK A +AAGNT++ KP+++T +
Sbjct: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185
Query: 626 TALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAV 685
TA +L KAG P GV+NI+ G+G G+ L HP++ + FTGS P ++I + A
Sbjct: 186 TAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA- 244
Query: 686 SNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFV 745
+ KK+SLELGGK+P IIF D LD+ + + + F N+GE C+ R+FV++SI+ EF+
Sbjct: 245 PHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFL 304
Query: 746 TRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQR--- 802
R VE +K K+G P D G KAHLEK+ Y + + EGA ++ G V +
Sbjct: 305 KRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQ-IWCGEGVDKLSL 363
Query: 803 -----PGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLAS 857
G+FM PTV TD++D EE FGP+ + F + + V++RAN+ +YGLA+
Sbjct: 364 PARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSE--EEVIERANNVKYGLAA 421
Query: 858 GVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTK 917
V++ ++ + V++KL++G V+ N + ++ PFGG+K SG G++ +++ + + + K
Sbjct: 422 TVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIK 481
Query: 918 TVTLEY 923
T+T+++
Sbjct: 482 TITVKH 487
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 269 bits (688), Expect = 8e-72
Identities = 168/478 (35%), Positives = 267/478 (55%), Gaps = 15/478 (3%)
Query: 446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARE 505
F+ G++ A T+ +P G+ + V+ + + AV AA +AF W ++A+E
Sbjct: 64 FVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAF--CRWREVSAKE 119
Query: 506 RGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGST 565
R L+ + +L+ +N+++LA I +SG A I S +F+ ++ G
Sbjct: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-HGEILYSAFFLEWFSEEARRVYGDI 178
Query: 566 IPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPL 625
I A+ R L K+P+GV A+I PWN+P M+ K A LAAG T+V+KPA+ TP
Sbjct: 179 IH-TPAKDRRALVL--KQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235
Query: 626 TALKFAELSVKAGFPKGVINIIPGSGGIA---GQRLSEHPDIRKLGFTGSTPIGKQIMKS 682
+AL AEL+ +AG P GV N+IP S A G+ + P + K+ FTGST GK I+
Sbjct: 236 SALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK-ILLH 294
Query: 683 CAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHD 742
A +++K+VS+ELGG +P I+F+ +D+AV M + F N G+ C+ + + V+ IHD
Sbjct: 295 HAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHD 354
Query: 743 EFVTRVVEEIKK-MKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQ 801
FV E +KK +++G+ + T GP ++ +EK+ + V +GAT+V GG++ Q
Sbjct: 355 AFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQ 414
Query: 802 RPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFT 861
F EPT+ +V M EE+FGP+ + KF + + AN+ + GLA ++
Sbjct: 415 LGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTE--EEAIAIANAADVGLAGYFYS 472
Query: 862 RDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTV 919
+D + V+E+LE G V +N + V PFGGVKQSG G++ + ++EYL+ K V
Sbjct: 473 QDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 260 bits (664), Expect = 5e-69
Identities = 168/491 (34%), Positives = 267/491 (54%), Gaps = 28/491 (5%)
Query: 446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARE 505
F+ G++ A T+ +P G+ + V+ + + AV AA +AF W ++A+E
Sbjct: 64 FVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAF--CRWREVSAKE 119
Query: 506 RGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGST 565
R L+ + +L+ +N+++LA I +SG A I S +F+ ++ G
Sbjct: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-HGEILYSAFFLEWFSEEARRVYGDI 178
Query: 566 IPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPL 625
I A+ R L K+P+GV A+I PWN+P M+ K A LAAG T+V+KPA+ TP
Sbjct: 179 IH-TPAKDRRALVL--KQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235
Query: 626 TALKFAE-------------LSVKAGFPKGVINIIPGSGGIA---GQRLSEHPDIRKLGF 669
+AL AE L+ +AG P GV N+IP S A G+ + P + K+ F
Sbjct: 236 SALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISF 295
Query: 670 TGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCI 729
TGST GK I+ A +++K+VS+ELGG +P I+F+ +D+AV M + F N G+ C+
Sbjct: 296 TGSTTTGK-ILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCV 354
Query: 730 AAGRLFVEESIHDEFVTRVVEEIKK-MKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVK 788
+ + V+ IHD FV E +KK +++G+ + T GP ++ +EK+ + V
Sbjct: 355 CSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVS 414
Query: 789 EGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRA 848
+GAT+V GG++ Q F EPT+ +V M EE+FGP+ + KF + + A
Sbjct: 415 KGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTE--EEAIAIA 472
Query: 849 NSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEE 908
N+ + GLA +++D + V+E+LE G V +N + V PFGGVKQSG G++ +
Sbjct: 473 NAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKY 532
Query: 909 ALNEYLKTKTV 919
++EYL+ K V
Sbjct: 533 GIDEYLELKYV 543
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 251 bits (642), Expect = 2e-66
Identities = 154/478 (32%), Positives = 258/478 (53%), Gaps = 57/478 (11%)
Query: 446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARE 505
FI+G+F D+ +P+ G C+V + +++ AV AA++AF + W + +E
Sbjct: 13 FIDGKFLPCSS--YIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS--WSSRSPQE 68
Query: 506 RGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGST 565
R R++ ++ADLLE++ EE A E+ D G LA I SVQ FR+FA T
Sbjct: 69 RSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFAS---SSLHHT 125
Query: 566 IPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPL 625
Q + +T + P+GV +I PWN PL +L WK A +AAGNT++ KP+++T +
Sbjct: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185
Query: 626 TALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAV 685
TA +L KAG P GV+NI+ G+G G+ L HP++ + FTGS P ++I + A
Sbjct: 186 TAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA- 244
Query: 686 SNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFV 745
+ KK+SLELGGK+P IIF D LD+ + + + F N+ + +V
Sbjct: 245 PHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQVRS----------------YV 288
Query: 746 TRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGF 805
R + E ++ G+ +D+ + P ++A G+
Sbjct: 289 KRALAEGAQIWCGEGVDKLS--LPARNQA-----------------------------GY 317
Query: 806 FMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDIN 865
FM PTV TD++D EE FGP+ + F + + V++RAN+ +YGLA+ V++ ++
Sbjct: 318 FMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSE--EEVIERANNVKYGLAATVWSSNVG 375
Query: 866 KAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTLEY 923
+ V++KL++G V+ N + ++ PFGG+K SG G++ +++ + + + KT+T+++
Sbjct: 376 RVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVKH 433
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 214 bits (546), Expect = 2e-55
Identities = 136/474 (28%), Positives = 239/474 (50%), Gaps = 17/474 (3%)
Query: 457 GKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADL 516
G+ T P + I +V AS+AD ++ V A++A++ W + A +RG ++ ++ D
Sbjct: 63 GEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKI--WADIPAPKRGEIVRQIGDA 120
Query: 517 LEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRN 576
L E + L ++ +L+ G + + + V Y G I G +P ++ +
Sbjct: 121 LREKIQVLGSLVSLEMGKILVEGVG-EVQEYVDICDYAVGLSRMIGGPILPSERSG---H 176
Query: 577 LTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVK 636
+ P+G+ II +N+P+ + W +A + GN + K A T L ++ ++ K
Sbjct: 177 ALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAK 236
Query: 637 A----GFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVS 692
P + ++ G I G +++ + L FTGST +GKQ+ +
Sbjct: 237 VLEDNKLPGAICSLTCGGADI-GTAMAKDERVNLLSFTGSTQVGKQV-GLMVQERFGRSL 294
Query: 693 LELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEI 752
LELGG + +I F D +L V + A G+ C A RLF+ ESIHDE V R+ +
Sbjct: 295 LELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAY 354
Query: 753 KKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVF 812
++++G+P D + +GP + K + L E KEG T+VYGG+ + RPG ++EPT+
Sbjct: 355 AQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIV 414
Query: 813 TDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDINKAM-YVS 871
T + +A E+F PI+ + KF+N + V N + GL+S +FT+D+ + ++
Sbjct: 415 TGLGHDASIAHTETFAPILYVFKFKNE--EEVFAWNNEVKQGLSSSIFTKDLGRIFRWLG 472
Query: 872 EK-LEAGTVFIN-TYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTLEY 923
K + G V +N + ++ FGG K +G G++ G +A +Y++ T T+ Y
Sbjct: 473 PKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINY 526
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 188 bits (478), Expect = 2e-47
Identities = 133/488 (27%), Positives = 240/488 (49%), Gaps = 24/488 (4%)
Query: 446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARE 505
FI G+F ++ K D NP I +V A+ A++D A+A+ K AF W +
Sbjct: 43 FIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFP--AWADTSVLS 100
Query: 506 RGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGST 565
R +++ R L++EN +E+A + L+ G A + + +Q + + G T
Sbjct: 101 RQQVLLRYQQLIKENLKEIAKLITLEQGKTLADA-EGDVFRGLQVVEHACSVTSLMMGET 159
Query: 566 IPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPL 625
+P + +L ++ + PLGVCA I P+N+P M+ W + GNT ++KP++ P
Sbjct: 160 MP--SITKDMDL-YSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPG 216
Query: 626 TALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAV 685
+ A+L +G P G +NII G A + +HPDI+ + F GS G+ I +
Sbjct: 217 ATMLLAKLLQDSGAPDGTLNIIHGQHE-AVNFICDHPDIKAISFVGSNKAGEYIFER-GS 274
Query: 686 SNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIA-AGRLFVEESIHDEF 744
+ K+V +G K+ ++ D + + +GA F G+ C+A + + V E+ ++
Sbjct: 275 RHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEA--KKW 332
Query: 745 VTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPG 804
+ +VE K +++ D GP E++ ++G KEGA+++ GR+++ G
Sbjct: 333 LPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKG 392
Query: 805 F----FMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVF 860
+ F+ PT+ ++V+ M KEE FGP++V+ + +D +Q N+ YG + +F
Sbjct: 393 YENGNFVGPTIISNVKPNMTCYKEEIFGPVLVV--LETETLDEAIQIVNNNPYGNGTAIF 450
Query: 861 TRDINKAMYVSEKLEAGTVFINTYNKTDVAAP---FGGVKQS--GFGKDLGEEALNEYLK 915
T + A + ++ G V +N V P F G + S G G++ + Y +
Sbjct: 451 TTNGATARKYAHLVDVGQVGVNV--PIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQ 508
Query: 916 TKTVTLEY 923
KT+T ++
Sbjct: 509 LKTITSQW 516
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 155 bits (392), Expect = 2e-37
Identities = 126/473 (26%), Positives = 228/473 (48%), Gaps = 32/473 (6%)
Query: 446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARE 505
++NG++ + + +P G + A DV AV AA+ AF+ W
Sbjct: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKG--WSAHPGVV 100
Query: 506 RGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGST 565
R + + RLA++++++Q L T+E+L +G + ++ Q Y A IQ ST
Sbjct: 101 RAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA-----IQAST 155
Query: 566 IPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLV--LKPAQVT 623
+ EP+GV +I+P + + + W+ LA G T+V + PA
Sbjct: 156 ---------QEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPA 206
Query: 624 PLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSC 683
PL A+L+ + G G++N++ G + L+ P IRK+ F G+ G+ + +S
Sbjct: 207 PLL---LAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSL 262
Query: 684 AVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDE 743
A ++ L LG +S L++ + ++D AV + A + ++G + RL ++ES+ DE
Sbjct: 263 A-GECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGL---RLLIQESVWDE 318
Query: 744 FVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGR-QVQR 802
+ R+ E + +++ G LD + D G + A + + ++ +GA + G +R
Sbjct: 319 AMRRLQERMGRLRSGRGLDGAVDMGARGAAA-CDLVQRFVREAQSQGAQVFQAGDVPSER 377
Query: 803 PGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTR 862
P F PT+ +++ A+ E P++V S F+ L AN T G ++ V++
Sbjct: 378 P--FYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAK--EALLVANGTPRGGSASVWSE 433
Query: 863 DINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLK 915
+ +A+ + L+ GTV+IN + D + P GG K+SG G + L EYL+
Sbjct: 434 RLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLR 486
Score = 89.7 bits (221), Expect = 1e-17
Identities = 72/250 (28%), Positives = 116/250 (46%), Gaps = 11/250 (4%)
Query: 442 PYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRM 501
PY F+ G+F A ++ I + G+ V+ D+ AV AA AF W
Sbjct: 527 PYGLFVGGRF-QAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPG--WAGQ 583
Query: 502 NARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKI 561
+ R L++ LA LE + LA+ L+ A + + +S + R + G +
Sbjct: 584 SPGARAALLWALAAALERRKSTLAS--RLERQGAELKAAEAEVELSARRLRAW-GARVQA 640
Query: 562 QGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQ 621
QG T+ Q R +EPLGV A++ P +PL+ A LA GNT+V+ P+
Sbjct: 641 QGHTL---QVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSA 697
Query: 622 VTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMK 681
PL AL+ + + FP G+ N++ G + L+ H D++ + + GS G Q ++
Sbjct: 698 ACPLLALEVCQ-DMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQ-GSQFVE 755
Query: 682 SCAVSNLKKV 691
+ NLK V
Sbjct: 756 WASAGNLKPV 765
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 143 bits (361), Expect = 6e-34
Identities = 116/437 (26%), Positives = 205/437 (46%), Gaps = 17/437 (3%)
Query: 479 LADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTL 538
++ + +AV A+ AF +G + R + + L L++E ++EL A D
Sbjct: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQ--LEALQRLIQEQEQELVGALAADLHKNEWN 58
Query: 539 ALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPL 598
A + ++ Y + + ++ + EPLGV +I WNYP
Sbjct: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118
Query: 599 MMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRL 658
+ +AAGN++VLKP++++ A A + + K + +I G + L
Sbjct: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTELL 177
Query: 659 SEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMG 718
E D + +TGST +GK IM + A +L V+LELGGKSP + +C+LD A R
Sbjct: 178 KERFD--HILYTGSTGVGKIIM-TAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234
Query: 719 AVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEK 778
F N G+ C+A + + SI ++ V ++ + +K+ G+ +S D+G H ++
Sbjct: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQR 293
Query: 779 LLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQN 838
++ G+ EG + YGG ++ PT+ TDV+ + +EE FGP++ I ++
Sbjct: 294 VM-----GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347
Query: 839 GDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFIN--TYNKTDVAAPFGGV 896
++ +Q N E LA +F+ + + + +G V N + T + PFGGV
Sbjct: 348 --LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405
Query: 897 KQSGFGKDLGEEALNEY 913
SG G G+++ +
Sbjct: 406 GNSGMGSYHGKKSFETF 422
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 143 bits (361), Expect = 6e-34
Identities = 116/437 (26%), Positives = 205/437 (46%), Gaps = 17/437 (3%)
Query: 479 LADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTL 538
++ + +AV A+ AF +G + R + + L L++E ++EL A D
Sbjct: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQ--LEALQRLIQEQEQELVGALAADLHKNEWN 58
Query: 539 ALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPL 598
A + ++ Y + + ++ + EPLGV +I WNYP
Sbjct: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118
Query: 599 MMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRL 658
+ +AAGN++VLKP++++ A A + + K + +I G + L
Sbjct: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTELL 177
Query: 659 SEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMG 718
E D + +TGST +GK IM + A +L V+LELGGKSP + +C+LD A R
Sbjct: 178 KERFD--HILYTGSTGVGKIIM-TAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234
Query: 719 AVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEK 778
F N G+ C+A + + SI ++ V ++ + +K+ G+ +S D+G H ++
Sbjct: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQR 293
Query: 779 LLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQN 838
++ G+ EG + YGG ++ PT+ TDV+ + +EE FGP++ I ++
Sbjct: 294 VM-----GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347
Query: 839 GDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFIN--TYNKTDVAAPFGGV 896
++ +Q N E LA +F+ + + + +G V N + T + PFGGV
Sbjct: 348 --LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405
Query: 897 KQSGFGKDLGEEALNEY 913
SG G G+++ +
Sbjct: 406 GNSGMGSYHGKKSFETF 422
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 143 bits (361), Expect = 6e-34
Identities = 116/437 (26%), Positives = 205/437 (46%), Gaps = 17/437 (3%)
Query: 479 LADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTL 538
++ + +AV A+ AF +G + R + + L L++E ++EL A D
Sbjct: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQ--LEALQRLIQEQEQELVGALAADLHKNEWN 58
Query: 539 ALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPL 598
A + ++ Y + + ++ + EPLGV +I WNYP
Sbjct: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118
Query: 599 MMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRL 658
+ +AAGN++VLKP++++ A A + + K + +I G + L
Sbjct: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTELL 177
Query: 659 SEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMG 718
E D + +TGST +GK IM + A +L V+LELGGKSP + +C+LD A R
Sbjct: 178 KERFD--HILYTGSTGVGKIIM-TAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234
Query: 719 AVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEK 778
F N G+ C+A + + SI ++ V ++ + +K+ G+ +S D+G H ++
Sbjct: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQR 293
Query: 779 LLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQN 838
++ G+ EG + YGG ++ PT+ TDV+ + +EE FGP++ I ++
Sbjct: 294 VM-----GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347
Query: 839 GDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFIN--TYNKTDVAAPFGGV 896
++ +Q N E LA +F+ + + + +G V N + T + PFGGV
Sbjct: 348 --LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405
Query: 897 KQSGFGKDLGEEALNEY 913
SG G G+++ +
Sbjct: 406 GNSGMGSYHGKKSFETF 422
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 139 bits (350), Expect = 1e-32
Identities = 100/337 (29%), Positives = 172/337 (51%), Gaps = 15/337 (4%)
Query: 579 FTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAG 638
+ + +PLGV II WNYP ++ +AAGN +++KP++++ TA A+L +
Sbjct: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKL-LPQY 154
Query: 639 FPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGK 698
+ + +I G + L + D + +TG+T +GK +M++ A +L V+LELGGK
Sbjct: 155 LDQDLYIVINGGVEETTELLKQRFD--HIFYTGNTAVGKIVMEAAA-KHLTPVTLELGGK 211
Query: 699 SPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIG 758
SP I DC+LD R + N G+ CIA + E S+ ++ V ++ E +K+ G
Sbjct: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YG 270
Query: 759 DPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDY 818
+ + S D+ + H +++L + EG + +GG + ++ PTV TDV+
Sbjct: 271 ENIKESPDYERIINLRHFKRIL-----SLLEGQKIAFGG-ETDEATRYIAPTVLTDVDPK 324
Query: 819 MYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGT 878
+ +EE FGPI+ I +N +D + N E LA VF+ + + ++ +G
Sbjct: 325 TKVMQEEIFGPILPIVPVKN--VDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGG 382
Query: 879 VFIN--TYNKTDVAAPFGGVKQSGFGKDLGEEALNEY 913
V N + T + PFGGV SG G G+ + + +
Sbjct: 383 VTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 139 bits (350), Expect = 1e-32
Identities = 100/337 (29%), Positives = 172/337 (51%), Gaps = 15/337 (4%)
Query: 579 FTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAG 638
+ + +PLGV II WNYP ++ +AAGN +++KP++++ TA A+L +
Sbjct: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKL-LPQY 154
Query: 639 FPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGK 698
+ + +I G + L + D + +TG+T +GK +M++ A +L V+LELGGK
Sbjct: 155 LDQDLYIVINGGVEETTELLKQRFD--HIFYTGNTAVGKIVMEAAA-KHLTPVTLELGGK 211
Query: 699 SPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIG 758
SP I DC+LD R + N G+ CIA + E S+ ++ V ++ E +K+ G
Sbjct: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YG 270
Query: 759 DPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDY 818
+ + S D+ + H +++L + EG + +GG + ++ PTV TDV+
Sbjct: 271 ENIKESPDYERIINLRHFKRIL-----SLLEGQKIAFGG-ETDEATRYIAPTVLTDVDPK 324
Query: 819 MYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGT 878
+ +EE FGPI+ I +N +D + N E LA VF+ + + ++ +G
Sbjct: 325 TKVMQEEIFGPILPIVPVKN--VDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGG 382
Query: 879 VFIN--TYNKTDVAAPFGGVKQSGFGKDLGEEALNEY 913
V N + T + PFGGV SG G G+ + + +
Sbjct: 383 VTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 135 bits (339), Expect = 2e-31
Identities = 111/451 (24%), Positives = 200/451 (44%), Gaps = 29/451 (6%)
Query: 468 GSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLE-ENQEELAT 526
G + K YA + ++KA+ AA A + EW +R ++ + AD+L + E+
Sbjct: 88 GHKVAKFCYADKSLLNKAIEAALAARK--EWDLKPIADRAQIFLKAADMLSGPRRAEILA 145
Query: 527 IEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLG 586
+ G A + FR+ A + +++G PI+ + + E G
Sbjct: 146 KTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQ-PISVPPSTNSTVYRGLE--G 202
Query: 587 VCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINI 646
A I P+N+ + A L GN ++ KP+ L + + +AG P +I
Sbjct: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
Query: 647 IPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVS-----NLKKVSLELGGKSPL 701
+P G + G ++ + + FTGS P K + K A + +++ E GGK+
Sbjct: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321
Query: 702 IIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPL 761
+ +++ V + + F G+ C A RL+V S+ + R++EE ++K+GDP
Sbjct: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381
Query: 762 DRSTDHG-------PQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTD 814
+ D G A ++K L++ + T++ GG+ G+F+EP +
Sbjct: 382 E---DFGTFFSAVIDAKSFARIKKWLEHARS--SPSLTILAGGKCDDSVGYFVEPCIVES 436
Query: 815 VEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANS-TEYGLASGVFTRDINKAMYVSEK 873
+ + KEE FGP++ + + + LQ +S T YGL VF++D + ++
Sbjct: 437 KDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKV 496
Query: 874 LE--AGTVFINTYNKTDVAA--PFGGVKQSG 900
L AG +IN + + PFGG + SG
Sbjct: 497 LRNAAGNFYINDKSTGSIVGQQPFGGARASG 527
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 135 bits (339), Expect = 2e-31
Identities = 111/451 (24%), Positives = 200/451 (44%), Gaps = 29/451 (6%)
Query: 468 GSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLE-ENQEELAT 526
G + K YA + ++KA+ AA A + EW +R ++ + AD+L + E+
Sbjct: 28 GHKVAKFCYADKSLLNKAIEAALAARK--EWDLKPIADRAQIFLKAADMLSGPRRAEILA 85
Query: 527 IEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLG 586
+ G A + FR+ A + +++G PI+ + + E G
Sbjct: 86 KTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQ-PISVPPSTNSTVYRGLE--G 142
Query: 587 VCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINI 646
A I P+N+ + A L GN ++ KP+ L + + +AG P +I
Sbjct: 143 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 201
Query: 647 IPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVS-----NLKKVSLELGGKSPL 701
+P G + G ++ + + FTGS P K + K A + +++ E GGK+
Sbjct: 202 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 261
Query: 702 IIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPL 761
+ +++ V + + F G+ C A RL+V S+ + R++EE ++K+GDP
Sbjct: 262 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 321
Query: 762 DRSTDHG-------PQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTD 814
+ D G A ++K L++ + T++ GG+ G+F+EP +
Sbjct: 322 E---DFGTFFSAVIDAKSFARIKKWLEHARS--SPSLTILAGGKCDDSVGYFVEPCIVES 376
Query: 815 VEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANS-TEYGLASGVFTRDINKAMYVSEK 873
+ + KEE FGP++ + + + LQ +S T YGL VF++D + ++
Sbjct: 377 KDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKV 436
Query: 874 LE--AGTVFINTYNKTDVAA--PFGGVKQSG 900
L AG +IN + + PFGG + SG
Sbjct: 437 LRNAAGNFYINDKSTGSIVGQQPFGGARASG 467
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 135 bits (339), Expect = 2e-31
Identities = 111/451 (24%), Positives = 200/451 (44%), Gaps = 29/451 (6%)
Query: 468 GSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLE-ENQEELAT 526
G + K YA + ++KA+ AA A + EW +R ++ + AD+L + E+
Sbjct: 88 GHKVAKFCYADKSLLNKAIEAALAARK--EWDLKPIADRAQIFLKAADMLSGPRRAEILA 145
Query: 527 IEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLG 586
+ G A + FR+ A + +++G PI+ + + E G
Sbjct: 146 KTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQ-PISVPPSTNSTVYRGLE--G 202
Query: 587 VCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINI 646
A I P+N+ + A L GN ++ KP+ L + + +AG P +I
Sbjct: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
Query: 647 IPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVS-----NLKKVSLELGGKSPL 701
+P G + G ++ + + FTGS P K + K A + +++ E GGK+
Sbjct: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321
Query: 702 IIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPL 761
+ +++ V + + F G+ C A RL+V S+ + R++EE ++K+GDP
Sbjct: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381
Query: 762 DRSTDHG-------PQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTD 814
+ D G A ++K L++ + T++ GG+ G+F+EP +
Sbjct: 382 E---DFGTFFSAVIDAKSFARIKKWLEHARS--SPSLTILAGGKCDDSVGYFVEPCIVES 436
Query: 815 VEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANS-TEYGLASGVFTRDINKAMYVSEK 873
+ + KEE FGP++ + + + LQ +S T YGL VF++D + ++
Sbjct: 437 KDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKV 496
Query: 874 LE--AGTVFINTYNKTDVAA--PFGGVKQSG 900
L AG +IN + + PFGG + SG
Sbjct: 497 LRNAAGNFYINDKSTGSIVGQQPFGGARASG 527
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 120 bits (302), Expect = 4e-27
Identities = 114/430 (26%), Positives = 186/430 (43%), Gaps = 25/430 (5%)
Query: 490 KDAFENGEWGRMNARERGRLMYRLADLLEENQEEL--ATIEALDSGAVYTLALKTHIGMS 547
++AF G A R + L L+EN++ L A + L A + + I
Sbjct: 12 REAFHAGR--TRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAISQG 69
Query: 548 VQTF--RYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKS 605
T R W ++ +P N A + F +KEP G+ II PWNYPL +
Sbjct: 70 EVTLALRNLRAW---MKDERVPKNLAT-QLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPL 125
Query: 606 AACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIR 665
LAAGN +VLKP++++ AE+ + + ++ G GQ L D
Sbjct: 126 VGALAAGNCVVLKPSEISKNVEKILAEV-LPQYVDQSCFAVVLGGPQETGQLLEHRFDY- 183
Query: 666 KLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKG 725
+ FTGS +GK +M + A +L V+LELGGK+P + ++C+ +FN G
Sbjct: 184 -IFFTGSPRVGKIVM-TAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAG 241
Query: 726 ENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCET 785
+ C+A + + + + + I + GD S + G ++ ++L
Sbjct: 242 QTCVAPDYVLCSPEMQERLLPALQSTITRF-YGDDPQSSPNLGRIINQKQFQRLRALL-- 298
Query: 786 GVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVL 845
G V G Q ++ PTV DV++ + +EE FGPI+ I Q+ +D +
Sbjct: 299 ----GCGRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQS--LDEAI 352
Query: 846 QRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINT--YNKTDVAAPFGGVKQSGFGK 903
+ N E LA F+ V + +G N + T + PFGGV SG G+
Sbjct: 353 EFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGR 412
Query: 904 DLGEEALNEY 913
G+ + + +
Sbjct: 413 YHGKFSFDTF 422
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 120 bits (302), Expect = 4e-27
Identities = 114/430 (26%), Positives = 186/430 (43%), Gaps = 25/430 (5%)
Query: 490 KDAFENGEWGRMNARERGRLMYRLADLLEENQEEL--ATIEALDSGAVYTLALKTHIGMS 547
++AF G A R + L L+EN++ L A + L A + + I
Sbjct: 12 REAFHAGR--TRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAISQG 69
Query: 548 VQTF--RYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKS 605
T R W ++ +P N A + F +KEP G+ II PWNYPL +
Sbjct: 70 EVTLALRNLRAW---MKDERVPKNLAT-QLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPL 125
Query: 606 AACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIR 665
LAAGN +VLKP++++ AE+ + + ++ G GQ L D
Sbjct: 126 VGALAAGNCVVLKPSEISKNVEKILAEV-LPQYVDQSCFAVVLGGPQETGQLLEHRFDY- 183
Query: 666 KLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKG 725
+ FTGS +GK +M + A +L V+LELGGK+P + ++C+ +FN G
Sbjct: 184 -IFFTGSPRVGKIVM-TAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAG 241
Query: 726 ENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCET 785
+ C+A + + + + + I + GD S + G ++ ++L
Sbjct: 242 QTCVAPDYVLCSPEMQERLLPALQSTITRF-YGDDPQSSPNLGRIINQKQFQRLRALL-- 298
Query: 786 GVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVL 845
G V G Q ++ PTV DV++ + +EE FGPI+ I Q+ +D +
Sbjct: 299 ----GCGRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQS--LDEAI 352
Query: 846 QRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINT--YNKTDVAAPFGGVKQSGFGK 903
+ N E LA F+ V + +G N + T + PFGGV SG G+
Sbjct: 353 EFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGR 412
Query: 904 DLGEEALNEY 913
G+ + + +
Sbjct: 413 YHGKFSFDTF 422
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 120 bits (302), Expect = 4e-27
Identities = 97/346 (28%), Positives = 158/346 (45%), Gaps = 17/346 (4%)
Query: 579 FTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAG 638
F KEP G+ II PWNYPL + LAAG+ +VLKP++++ T AE+ +
Sbjct: 18 FIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEV-LPQY 76
Query: 639 FPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGK 698
+ ++ G GQ L D + FTGS +GK +M + A +L V+LELGGK
Sbjct: 77 LDQSCFAVVLGGPQETGQLLEHKLDY--IFFTGSPRVGKIVM-TAATKHLTPVTLELGGK 133
Query: 699 SPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIG 758
+P + ++C+ +FN G+ C+A + + + + + I + G
Sbjct: 134 NPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRF-YG 192
Query: 759 DPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDY 818
D S + G ++ ++L G V G Q ++ PTV DV++
Sbjct: 193 DDPQSSPNLGRIINQKQFQRLRALL------GCGRVAIGGQSNESDRYIAPTVLVDVQET 246
Query: 819 MYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGT 878
+ +EE FGPI+ I Q+ +D ++ N E LA F+ + E+ +G+
Sbjct: 247 EPVMQEEIFGPILPIVNVQS--VDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGS 304
Query: 879 VFIN---TYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTL 921
N TY ++ PFGGV SG G+ G+ + + +T L
Sbjct: 305 FGGNEGFTYISL-LSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLL 349
>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 120 bits (302), Expect = 4e-27
Identities = 97/346 (28%), Positives = 158/346 (45%), Gaps = 17/346 (4%)
Query: 579 FTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAG 638
F KEP G+ II PWNYPL + LAAG+ +VLKP++++ T AE+ +
Sbjct: 18 FIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEV-LPQY 76
Query: 639 FPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGK 698
+ ++ G GQ L D + FTGS +GK +M + A +L V+LELGGK
Sbjct: 77 LDQSCFAVVLGGPQETGQLLEHKLDY--IFFTGSPRVGKIVM-TAATKHLTPVTLELGGK 133
Query: 699 SPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIG 758
+P + ++C+ +FN G+ C+A + + + + + I + G
Sbjct: 134 NPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRF-YG 192
Query: 759 DPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDY 818
D S + G ++ ++L G V G Q ++ PTV DV++
Sbjct: 193 DDPQSSPNLGRIINQKQFQRLRALL------GCGRVAIGGQSNESDRYIAPTVLVDVQET 246
Query: 819 MYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGT 878
+ +EE FGPI+ I Q+ +D ++ N E LA F+ + E+ +G+
Sbjct: 247 EPVMQEEIFGPILPIVNVQS--VDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGS 304
Query: 879 VFIN---TYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTL 921
N TY ++ PFGGV SG G+ G+ + + +T L
Sbjct: 305 FGGNEGFTYISL-LSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLL 349
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 119 bits (298), Expect = 1e-26
Identities = 94/337 (27%), Positives = 153/337 (45%), Gaps = 15/337 (4%)
Query: 579 FTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAG 638
F +KEP G+ II PWNYPL + LAAGN +VLKP++++ AE+ +
Sbjct: 62 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEV-LPQY 120
Query: 639 FPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGK 698
+ ++ G GQ L D + FTGS +GK +M + A +L V+LELGGK
Sbjct: 121 VDQSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVM-TAAAKHLTPVTLELGGK 177
Query: 699 SPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIG 758
+P + ++C+ +FN G+ C+A + + + + + I + G
Sbjct: 178 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRF-YG 236
Query: 759 DPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDY 818
D S + G ++ ++L G V G Q ++ PTV DV++
Sbjct: 237 DDPQSSPNLGRIINQKQFQRLRALL------GCGRVAIGGQSDESDRYIAPTVLVDVQEM 290
Query: 819 MYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGT 878
+ +EE FGPI+ I Q+ +D ++ N E LA F+ V + +G
Sbjct: 291 EPVMQEEIFGPILPIVNVQS--LDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGG 348
Query: 879 VFINT--YNKTDVAAPFGGVKQSGFGKDLGEEALNEY 913
N + T + PFGGV SG G+ G+ + + +
Sbjct: 349 FCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 385
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,013,384
Number of Sequences: 37866
Number of extensions: 1541944
Number of successful extensions: 3328
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 3169
Number of HSP's gapped (non-prelim): 49
length of query: 923
length of database: 18,247,518
effective HSP length: 112
effective length of query: 811
effective length of database: 14,006,526
effective search space: 11359292586
effective search space used: 11359292586
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.