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Search of human proteins with 236461509
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]
(607 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens] 1221 0.0
gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens] 1209 0.0
gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens] 1186 0.0
gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens] 1179 0.0
gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens] 1162 0.0
gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens] 1129 0.0
gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens] 733 0.0
gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens] 733 0.0
gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens] 700 0.0
gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens] 486 e-137
gi|7669532 neuregulin 2 isoform 4 [Homo sapiens] 393 e-109
gi|7669530 neuregulin 2 isoform 3 [Homo sapiens] 379 e-105
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens] 375 e-104
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens] 366 e-101
gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens] 353 2e-97
gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens] 323 4e-88
gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens] 323 4e-88
gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens] 322 5e-88
gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens] 310 2e-84
gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens] 280 4e-75
gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens] 138 2e-32
gi|66730481 neuregulin 3 [Homo sapiens] 108 1e-23
gi|110349719 titin isoform N2-A [Homo sapiens] 59 2e-08
gi|221316757 neurotrimin isoform 3 [Homo sapiens] 52 1e-06
gi|45594240 limbic system-associated membrane protein [Homo sapi... 52 2e-06
gi|221316762 neurotrimin isoform 4 [Homo sapiens] 51 3e-06
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 51 3e-06
gi|115298665 neurotrimin isoform 2 [Homo sapiens] 51 3e-06
gi|7705413 neurotrimin isoform 1 [Homo sapiens] 51 3e-06
gi|110349717 titin isoform novex-2 [Homo sapiens] 50 8e-06
>gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]
Length = 607
Score = 1221 bits (3160), Expect = 0.0
Identities = 607/607 (100%), Positives = 607/607 (100%)
Query: 1 MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 1 MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
Query: 61 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 120
KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA
Sbjct: 61 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 120
Query: 121 STEGAYVSSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTG 180
STEGAYVSSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTG
Sbjct: 121 STEGAYVSSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTG 180
Query: 181 DRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKK 240
DRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKK
Sbjct: 181 DRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKK 240
Query: 241 LHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFS 300
LHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFS
Sbjct: 241 LHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFS 300
Query: 301 TSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLN 360
TSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLN
Sbjct: 301 TSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLN 360
Query: 361 GTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMS 420
GTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMS
Sbjct: 361 GTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMS 420
Query: 421 PPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLP 480
PPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLP
Sbjct: 421 PPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLP 480
Query: 481 ASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNS 540
ASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNS
Sbjct: 481 ASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNS 540
Query: 541 ESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIA 600
ESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIA
Sbjct: 541 ESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIA 600
Query: 601 NQDPIAV 607
NQDPIAV
Sbjct: 601 NQDPIAV 607
>gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]
Length = 624
Score = 1209 bits (3129), Expect = 0.0
Identities = 606/624 (97%), Positives = 607/624 (97%), Gaps = 17/624 (2%)
Query: 1 MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 1 MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
Query: 61 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 120
KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA
Sbjct: 61 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 120
Query: 121 STEGAYVSS-----------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 163
STEGAYVSS +TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
Sbjct: 121 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 180
Query: 164 LSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVV 223
LSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVV
Sbjct: 181 LSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVV 240
Query: 224 GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKN 283
GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKN
Sbjct: 241 GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKN 300
Query: 284 VISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSV 343
VISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSV
Sbjct: 301 VISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSV 360
Query: 344 ENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP 403
ENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP
Sbjct: 361 ENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP 420
Query: 404 VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQ 463
VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQ
Sbjct: 421 VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQ 480
Query: 464 QFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHI 523
QFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHI
Sbjct: 481 QFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHI 540
Query: 524 ANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG 583
ANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG
Sbjct: 541 ANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG 600
Query: 584 RFSTQEEIQARLSSVIANQDPIAV 607
RFSTQEEIQARLSSVIANQDPIAV
Sbjct: 601 RFSTQEEIQARLSSVIANQDPIAV 624
>gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]
Length = 645
Score = 1186 bits (3067), Expect = 0.0
Identities = 594/612 (97%), Positives = 595/612 (97%), Gaps = 17/612 (2%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS--- 129
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
Query: 130 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 175
+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 213
Query: 176 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 235
NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 214 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 273
Query: 236 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 295
KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 274 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 333
Query: 296 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 355
ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 334 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 393
Query: 356 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 415
RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP
Sbjct: 394 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 453
Query: 416 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 475
PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD
Sbjct: 454 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 513
Query: 476 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 535
SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS
Sbjct: 514 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 573
Query: 536 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 595
QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL
Sbjct: 574 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 633
Query: 596 SSVIANQDPIAV 607
SSVIANQDPIAV
Sbjct: 634 SSVIANQDPIAV 645
>gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]
Length = 590
Score = 1179 bits (3049), Expect = 0.0
Identities = 590/607 (97%), Positives = 590/607 (97%), Gaps = 17/607 (2%)
Query: 1 MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 1 MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
Query: 61 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 120
KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN
Sbjct: 61 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 112
Query: 121 STEGAYVSSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTG 180
ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTG
Sbjct: 113 ---------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTG 163
Query: 181 DRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKK 240
DRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKK
Sbjct: 164 DRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKK 223
Query: 241 LHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFS 300
LHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFS
Sbjct: 224 LHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFS 283
Query: 301 TSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLN 360
TSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLN
Sbjct: 284 TSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLN 343
Query: 361 GTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMS 420
GTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMS
Sbjct: 344 GTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMS 403
Query: 421 PPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLP 480
PPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLP
Sbjct: 404 PPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLP 463
Query: 481 ASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNS 540
ASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNS
Sbjct: 464 ASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNS 523
Query: 541 ESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIA 600
ESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIA
Sbjct: 524 ESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIA 583
Query: 601 NQDPIAV 607
NQDPIAV
Sbjct: 584 NQDPIAV 590
>gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]
Length = 637
Score = 1162 bits (3005), Expect = 0.0
Identities = 586/612 (95%), Positives = 587/612 (95%), Gaps = 25/612 (4%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS--- 129
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
Query: 130 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 175
+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 213
Query: 176 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 235
NEFTGDRCQNYVMASFYK AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 214 NEFTGDRCQNYVMASFYK--------AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 265
Query: 236 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 295
KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 266 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 325
Query: 296 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 355
ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 326 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 385
Query: 356 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 415
RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP
Sbjct: 386 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 445
Query: 416 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 475
PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD
Sbjct: 446 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 505
Query: 476 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 535
SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS
Sbjct: 506 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 565
Query: 536 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 595
QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL
Sbjct: 566 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 625
Query: 596 SSVIANQDPIAV 607
SSVIANQDPIAV
Sbjct: 626 SSVIANQDPIAV 637
>gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]
Length = 640
Score = 1129 bits (2919), Expect = 0.0
Identities = 573/612 (93%), Positives = 575/612 (93%), Gaps = 22/612 (3%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS--- 129
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
Query: 130 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 175
+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQ 213
Query: 176 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 235
FTG RC V +AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 214 PGFTGARCTENVPMKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 268
Query: 236 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 295
KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 269 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 328
Query: 296 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 355
ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 329 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 388
Query: 356 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 415
RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP
Sbjct: 389 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 448
Query: 416 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 475
PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD
Sbjct: 449 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 508
Query: 476 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 535
SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS
Sbjct: 509 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 568
Query: 536 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 595
QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL
Sbjct: 569 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 628
Query: 596 SSVIANQDPIAV 607
SSVIANQDPIAV
Sbjct: 629 SSVIANQDPIAV 640
>gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]
Length = 459
Score = 733 bits (1893), Expect = 0.0
Identities = 369/396 (93%), Positives = 371/396 (93%), Gaps = 25/396 (6%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS--- 129
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
Query: 130 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 175
+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 213
Query: 176 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 235
NEFTGDRCQNYVMASFYK AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 214 NEFTGDRCQNYVMASFYK--------AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 265
Query: 236 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 295
KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 266 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 325
Query: 296 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 355
ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 326 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 385
Query: 356 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERY 391
RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER+
Sbjct: 386 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERH 421
>gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]
Length = 420
Score = 733 bits (1891), Expect = 0.0
Identities = 369/395 (93%), Positives = 370/395 (93%), Gaps = 25/395 (6%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS--- 129
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
Query: 130 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 175
+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 213
Query: 176 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 235
NEFTGDRCQNYVMASFYK AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 214 NEFTGDRCQNYVMASFYK--------AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 265
Query: 236 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 295
KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 266 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 325
Query: 296 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 355
ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 326 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 385
Query: 356 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER 390
RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER
Sbjct: 386 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER 420
>gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]
Length = 462
Score = 700 bits (1807), Expect = 0.0
Identities = 356/396 (89%), Positives = 359/396 (90%), Gaps = 22/396 (5%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS--- 129
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
Query: 130 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 175
+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQ 213
Query: 176 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 235
FTG RC V +AEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 214 PGFTGARCTENVPMKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 268
Query: 236 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 295
KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 269 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 328
Query: 296 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 355
ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 329 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 388
Query: 356 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERY 391
RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER+
Sbjct: 389 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERH 424
>gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]
Length = 308
Score = 486 bits (1251), Expect = e-137
Identities = 240/263 (91%), Positives = 243/263 (92%), Gaps = 5/263 (1%)
Query: 129 SATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVM 188
+ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG RC V
Sbjct: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
Query: 189 ASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS 248
+AEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS
Sbjct: 73 MKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS 127
Query: 249 LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA 308
LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA
Sbjct: 128 LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA 187
Query: 309 HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC 368
HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC
Sbjct: 188 HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC 247
Query: 369 NSFLRHARETPDSYRDSPHSERY 391
NSFLRHARETPDSYRDSPHSER+
Sbjct: 248 NSFLRHARETPDSYRDSPHSERH 270
>gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
Length = 852
Score = 393 bits (1009), Expect = e-109
Identities = 249/630 (39%), Positives = 353/630 (56%), Gaps = 82/630 (13%)
Query: 3 KGRAGRVGTT--ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
K G++ T A P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR
Sbjct: 222 KKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS- 280
Query: 61 KPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGM 118
++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 281 --RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRL------------ 326
Query: 119 PASTEGAYVSSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEF 178
YV+S ++T ++ + H KC E K++CVNGG C+ ++ ++ S CKCP +
Sbjct: 327 -------YVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGY 376
Query: 179 TGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQR 238
TGDRCQ + M +F KHLG E EAEELYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQR
Sbjct: 377 TGDRCQQFAMVNFSKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQR 436
Query: 239 KKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETS 298
K++H+ LRQ++ N ++ANGP HP PE +Q+ + Y+SKNV +++H++ RE ET+
Sbjct: 437 KQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQMAD-YISKNVPATDHVIRRETETT 494
Query: 299 FSTSHYTSTAHHSTTVTQT-----PSHSWSNGHTESILSESHSVIVMSSVENSRHSSP-- 351
FS SH S +HH +T T T SH+WS +ES+ S+S S I++SSV S+ +SP
Sbjct: 495 FSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPAC 554
Query: 352 --TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTP 409
R R + H ++ DS RDSPHSERYVSA+TTPAR+SPVDFH
Sbjct: 555 VEARARRAAAYNLEERRRATAPPYH--DSVDSLRDSPHSERYVSALTTPARLSPVDFHYS 612
Query: 410 SSPKSPPSEMSPPVSSMTVSMPSMA-VSPFMEEERPLLLVTPPRLREKKFDHHP------ 462
+ + P E++ P S+ VS+P A +S + E++PLL P P
Sbjct: 613 LATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADM 672
Query: 463 -QQFSSFHHNPAHDS------------NSLPASPLRIVEDEEYETTQEYEPAQEPVKKL- 508
+ + S+++ A SLPASP RI ED+EYETTQE P P +
Sbjct: 673 QRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRAR 732
Query: 509 -------ANSRRAKRTKPNGHIANR-------LEVDSNTSSQSSNSESETEDERVG---- 550
A RR +R++ NG A R L + S + S+++ + D+ G
Sbjct: 733 GASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAA 792
Query: 551 EDTPFLGIQNPL-AASLEATPAFRLADSRT 579
E TPFLG++ A ++ P ADSRT
Sbjct: 793 ESTPFLGLRGAHDALRSDSPPLCPAADSRT 822
>gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]
Length = 858
Score = 379 bits (973), Expect = e-105
Identities = 247/636 (38%), Positives = 349/636 (54%), Gaps = 88/636 (13%)
Query: 3 KGRAGRVGTT--ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
K G++ T A P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR
Sbjct: 222 KKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS- 280
Query: 61 KPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGM 118
++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 281 --RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRL------------ 326
Query: 119 PASTEGAYVSSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEF 178
YV+S ++T ++ + H KC E K++CVNGG C+ ++ ++ S CKCPN F
Sbjct: 327 -------YVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPNGF 376
Query: 179 TGDRCQNYVMASFY------KHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYC 232
G RC + Y KHLG E EAEELYQKRVLTITGIC+ALLVVGI+CVVAYC
Sbjct: 377 FGQRCLEKLPLRLYMPDPKQKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYC 436
Query: 233 KTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVE 292
KTKKQRK++H+ LRQ++ N ++ANGP HP PE +Q+ + Y+SKNV +++H++
Sbjct: 437 KTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQMAD-YISKNVPATDHVIR 494
Query: 293 REAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNGHTESILSESHSVIVMSSVENSR 347
RE ET+FS SH S +HH +T T T SH+WS +ES+ S+S S I++SSV S+
Sbjct: 495 RETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSK 554
Query: 348 HSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP 403
+SP R R + H ++ DS RDSPHSERYVSA+TTPAR+SP
Sbjct: 555 CNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDSLRDSPHSERYVSALTTPARLSP 612
Query: 404 VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMA-VSPFMEEERPLLLVTPPRLREKKFDHHP 462
VDFH + + P E++ P S+ VS+P A +S + E++PLL P P
Sbjct: 613 VDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGP 672
Query: 463 -------QQFSSFHHNPAHDS------------NSLPASPLRIVEDEEYETTQEYEPAQE 503
+ + S+++ A SLPASP RI ED+EYETTQE P
Sbjct: 673 GPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPP 732
Query: 504 PVKKL--------ANSRRAKRTKPNGHIANR-------LEVDSNTSSQSSNSESETEDER 548
P + A RR +R++ NG A R L + S + S+++ + D+
Sbjct: 733 PRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDA 792
Query: 549 VG----EDTPFLGIQNPL-AASLEATPAFRLADSRT 579
G E TPFLG++ A ++ P ADSRT
Sbjct: 793 DGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT 828
>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
Length = 844
Score = 375 bits (963), Expect = e-104
Identities = 244/630 (38%), Positives = 348/630 (55%), Gaps = 90/630 (14%)
Query: 3 KGRAGRVGTT--ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
K G++ T A P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR
Sbjct: 222 KKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS- 280
Query: 61 KPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGM 118
++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 281 --RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRL------------ 326
Query: 119 PASTEGAYVSSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEF 178
YV+S ++T ++ + H KC E K++CVNGG C+ ++ ++ S CKCP +
Sbjct: 327 -------YVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGY 376
Query: 179 TGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQR 238
TGDRCQ + M +F K AEELYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQR
Sbjct: 377 TGDRCQQFAMVNFSK--------AEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQR 428
Query: 239 KKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETS 298
K++H+ LRQ++ N ++ANGP HP PE +Q+ + Y+SKNV +++H++ RE ET+
Sbjct: 429 KQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQMAD-YISKNVPATDHVIRRETETT 486
Query: 299 FSTSHYTSTAHHSTTVTQT-----PSHSWSNGHTESILSESHSVIVMSSVENSRHSSP-- 351
FS SH S +HH +T T T SH+WS +ES+ S+S S I++SSV S+ +SP
Sbjct: 487 FSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPAC 546
Query: 352 --TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTP 409
R R + H ++ DS RDSPHSERYVSA+TTPAR+SPVDFH
Sbjct: 547 VEARARRAAAYNLEERRRATAPPYH--DSVDSLRDSPHSERYVSALTTPARLSPVDFHYS 604
Query: 410 SSPKSPPSEMSPPVSSMTVSMPSMA-VSPFMEEERPLLLVTPPRLREKKFDHHP------ 462
+ + P E++ P S+ VS+P A +S + E++PLL P P
Sbjct: 605 LATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADM 664
Query: 463 -QQFSSFHHNPAHDS------------NSLPASPLRIVEDEEYETTQEYEPAQEPVKKL- 508
+ + S+++ A SLPASP RI ED+EYETTQE P P +
Sbjct: 665 QRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRAR 724
Query: 509 -------ANSRRAKRTKPNGHIANR-------LEVDSNTSSQSSNSESETEDERVG---- 550
A RR +R++ NG A R L + S + S+++ + D+ G
Sbjct: 725 GASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAA 784
Query: 551 EDTPFLGIQNPL-AASLEATPAFRLADSRT 579
E TPFLG++ A ++ P ADSRT
Sbjct: 785 ESTPFLGLRGAHDALRSDSPPLCPAADSRT 814
>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
Length = 850
Score = 366 bits (939), Expect = e-101
Identities = 241/630 (38%), Positives = 345/630 (54%), Gaps = 84/630 (13%)
Query: 3 KGRAGRVGTT--ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
K G++ T A P+LK+MKSQ G K L+CE ++ ++WFK+G ELNR
Sbjct: 222 KKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRS- 280
Query: 61 KPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGM 118
++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 281 --RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRL------------ 326
Query: 119 PASTEGAYVSSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEF 178
YV+S ++T ++ + H KC E K++CVNGG C+ ++ ++ S CKCPN F
Sbjct: 327 -------YVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPNGF 376
Query: 179 TGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQR 238
G RC + Y + +AEELYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQR
Sbjct: 377 FGQRCLEKLPLRLY--MPDPKQKAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQR 434
Query: 239 KKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETS 298
K++H+ LRQ++ N ++ANGP HP PE +Q+ + Y+SKNV +++H++ RE ET+
Sbjct: 435 KQMHNHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQMAD-YISKNVPATDHVIRRETETT 492
Query: 299 FSTSHYTSTAHHSTTVTQT-----PSHSWSNGHTESILSESHSVIVMSSVENSRHSSP-- 351
FS SH S +HH +T T T SH+WS +ES+ S+S S I++SSV S+ +SP
Sbjct: 493 FSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPAC 552
Query: 352 --TGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTP 409
R R + H ++ DS RDSPHSERYVSA+TTPAR+SPVDFH
Sbjct: 553 VEARARRAAAYNLEERRRATAPPYH--DSVDSLRDSPHSERYVSALTTPARLSPVDFHYS 610
Query: 410 SSPKSPPSEMSPPVSSMTVSMPSMA-VSPFMEEERPLLLVTPPRLREKKFDHHP------ 462
+ + P E++ P S+ VS+P A +S + E++PLL P P
Sbjct: 611 LATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADM 670
Query: 463 -QQFSSFHHNPAHDS------------NSLPASPLRIVEDEEYETTQEYEPAQEPVKKL- 508
+ + S+++ A SLPASP RI ED+EYETTQE P P +
Sbjct: 671 QRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRAR 730
Query: 509 -------ANSRRAKRTKPNGHIANR-------LEVDSNTSSQSSNSESETEDERVG---- 550
A RR +R++ NG A R L + S + S+++ + D+ G
Sbjct: 731 GASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAA 790
Query: 551 EDTPFLGIQNPL-AASLEATPAFRLADSRT 579
E TPFLG++ A ++ P ADSRT
Sbjct: 791 ESTPFLGLRGAHDALRSDSPPLCPAADSRT 820
>gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens]
Length = 241
Score = 353 bits (907), Expect = 2e-97
Identities = 179/197 (90%), Positives = 180/197 (91%), Gaps = 17/197 (8%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYV----- 127
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYV
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
Query: 128 ------------SSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 175
SS+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 213
Query: 176 NEFTGDRCQNYVMASFY 192
NEFTGDRCQNYVMASFY
Sbjct: 214 NEFTGDRCQNYVMASFY 230
>gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens]
Length = 207
Score = 323 bits (827), Expect = 4e-88
Identities = 163/180 (90%), Positives = 163/180 (90%), Gaps = 17/180 (9%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATS 132
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN ATS
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-----------------ATS 136
Query: 133 TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 192
TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY
Sbjct: 137 TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 196
>gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens]
Length = 422
Score = 323 bits (827), Expect = 4e-88
Identities = 163/180 (90%), Positives = 163/180 (90%), Gaps = 17/180 (9%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 249 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 308
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATS 132
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN ATS
Sbjct: 309 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-----------------ATS 351
Query: 133 TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 192
TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY
Sbjct: 352 TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 411
>gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens]
Length = 194
Score = 322 bits (826), Expect = 5e-88
Identities = 161/161 (100%), Positives = 161/161 (100%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATS 132
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATS
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATS 153
Query: 133 TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 173
TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 154 TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 194
>gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens]
Length = 211
Score = 310 bits (795), Expect = 2e-84
Identities = 160/178 (89%), Positives = 161/178 (90%), Gaps = 17/178 (9%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYV----- 127
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYV
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
Query: 128 ------------SSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 173
SS+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 211
>gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens]
Length = 177
Score = 280 bits (715), Expect = 4e-75
Identities = 144/161 (89%), Positives = 144/161 (89%), Gaps = 17/161 (10%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATS 132
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN ATS
Sbjct: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-----------------ATS 136
Query: 133 TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 173
TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 137 TSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 177
>gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]
Length = 296
Score = 138 bits (347), Expect = 2e-32
Identities = 62/63 (98%), Positives = 63/63 (100%)
Query: 130 ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 189
+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA
Sbjct: 223 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 282
Query: 190 SFY 192
SFY
Sbjct: 283 SFY 285
>gi|66730481 neuregulin 3 [Homo sapiens]
Length = 696
Score = 108 bits (270), Expect = 1e-23
Identities = 97/396 (24%), Positives = 178/396 (44%), Gaps = 35/396 (8%)
Query: 131 TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNY---- 186
T+ ST + H C +K+ +C+N GECF+++ L+ ++ C+C + G RC +
Sbjct: 277 TTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKH-CRCKEGYQGVRCDQFLPKT 335
Query: 187 --VMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDR 244
+++ HLGIEFME+EE+YQ++VL+I+ I +++VG+ C Y K+KKQ K++ ++
Sbjct: 336 DSILSDPTDHLGIEFMESEEVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQEQ 395
Query: 245 LRQSLRSERNNMMNIANGPHHPNPPPENVQLVN-QYVSKNVISSEHIVEREAETSFSTSH 303
L+ + ++ + N +VQL N V ++ +++ +E+ E+SF
Sbjct: 396 LKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTA---LEKMMESSF---- 448
Query: 304 YTSTAHHSTTVTQTPSH-SWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGT 362
S +P S S H S+ S + + PR RL G
Sbjct: 449 ---VGPQSFPEVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGI 505
Query: 363 GGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP---PSEM 419
GP + E+ +D+ + Y S+ R + ++ PS +P E
Sbjct: 506 VGPA-----YQQLEESRIPDQDTIPCQGYSSSGLKTQRNTSINMQLPSRETNPYFNSLEQ 560
Query: 420 SPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSL 479
V + S+ + P + E L + P + E K ++ ++ + S+
Sbjct: 561 KDLVGYSSTRASSVPIIPSVGLEETCLQM--PGISEVK----SIKWCKNSYSADVVNVSI 614
Query: 480 PASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAK 515
P S I E +E + E QE ++ L ++RR++
Sbjct: 615 PVSDCLIAEQQEVKIL--LETVQEQIRILTDARRSE 648
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 58.5 bits (140), Expect = 2e-08
Identities = 53/212 (25%), Positives = 88/212 (41%), Gaps = 18/212 (8%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
A P ++++ E A G CE S ++RF+WFK G E+ +K I+
Sbjct: 3454 AAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIYESDK---CSIRSSKY 3509
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATS 132
S L I + + D GEY CK ++ G+ S +A +T+ E+ + +V A
Sbjct: 3510 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAK 3569
Query: 133 --TSTTGTSHLVKCAEKE-------KTFCVNGGECFMVKDLSN-----PSRYLCKCPNEF 178
+ TGT + +K+ + ++ E + +LSN Y CK N+F
Sbjct: 3570 FICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKF 3629
Query: 179 TGDRCQNYVMASFYKHLGIEFMEAEELYQKRV 210
D CQ ++ H E + K+V
Sbjct: 3630 GADICQAELIIIDKPHFIKELEPVQSAINKKV 3661
Score = 52.0 bits (123), Expect = 2e-06
Identities = 44/197 (22%), Positives = 79/197 (40%), Gaps = 19/197 (9%)
Query: 8 RVGTTALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
RV +PP K++ + GS + + C+ S + +WFK+G E++ K + +
Sbjct: 5229 RVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLP-ISAQWFKDGKEISTSAKYRLVC 5287
Query: 67 IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAY 126
++ L +N L D+ Y CKV + G+D+ S +T+ E + P +
Sbjct: 5288 HERSVS---LEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLV-KPGRQQAIP 5343
Query: 127 VSSAT-STSTTGTSHLVKCAEKEKTFCVNGGECFM------------VKDLSNPSRYLCK 173
S+ GT K+ V+G +CF+ D S +Y C
Sbjct: 5344 DSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCH 5403
Query: 174 CPNEFTGDRCQNYVMAS 190
N+ D C ++ +
Sbjct: 5404 VTNDVGSDSCTTMLLVT 5420
Score = 51.2 bits (121), Expect = 3e-06
Identities = 41/178 (23%), Positives = 75/178 (42%), Gaps = 18/178 (10%)
Query: 19 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 78
K +++ +S L C+ + +R WFK+G E+ ++ +I G + L I
Sbjct: 4117 KPLRNVDSVVNGTCRLDCKIAGSLP-MRVSWFKDGKEIAASDR---YRIAFVEGTASLEI 4172
Query: 79 NKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATSTST-TG 137
+ + D+G + C+ + +G+ +S + + E +T P S + S+ ST G
Sbjct: 4173 IRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVT-KPGSKDVLPGSAVCLKSTFQG 4231
Query: 138 TSHLVKCAEKEKTFCVNGGECFMVKD------------LSNPSRYLCKCPNEFTGDRC 183
++ L K V+GG C++ K+ S+ Y CK N G C
Sbjct: 4232 STPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVEC 4289
Score = 50.8 bits (120), Expect = 4e-06
Identities = 50/227 (22%), Positives = 90/227 (39%), Gaps = 17/227 (7%)
Query: 3 KGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKP 62
K +G + P + + S++ GS + L+ T + L +WFK EL
Sbjct: 4194 KDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLK-STFQGSTPLTIRWFKGNKELVSGG-- 4250
Query: 63 QNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGM-PAS 121
+ I K+ +S L + +DSG Y CKV + G SAN+ + E + + P+
Sbjct: 4251 -SCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQ 4309
Query: 122 TEGAYVSSATSTSTTGTSHL----------VKCAEKEKTFCVNGGECFMVKD--LSNPSR 169
++ + TGT + +K + K + V + D + +
Sbjct: 4310 LLKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGE 4369
Query: 170 YLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGI 216
Y+C+ NE D C + V+ + EF E L + V+ + +
Sbjct: 4370 YMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEV 4416
Score = 50.1 bits (118), Expect = 6e-06
Identities = 45/187 (24%), Positives = 74/187 (39%), Gaps = 18/187 (9%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P ++E+K E S + L CE + W KN E+ K + +
Sbjct: 4955 PTFIRELKPVEVVKYSDVELECEVTGT-PPFEVTWLKNNREIRSSKK---YTLTDRVSVF 5010
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATSTS 134
L I K +D+GEY C V ++ G+ S S + + E I + +T SSAT S
Sbjct: 5011 NLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKI-ENTTTVLKSSATFQS 5069
Query: 135 TTGTSHLVKCA---------EKEKTFC--VNGGECFMVKDLSN--PSRYLCKCPNEFTGD 181
T S + E + + V+ ++ + N RY C+ NE +
Sbjct: 5070 TVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVE 5129
Query: 182 RCQNYVM 188
RC +++
Sbjct: 5130 RCYAFLL 5136
Score = 49.7 bits (117), Expect = 8e-06
Identities = 35/129 (27%), Positives = 62/129 (48%), Gaps = 11/129 (8%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P + + +SQ G ++ CE S E S +WFKN ++ + N+ I +
Sbjct: 33134 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 33189
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIV-----ESNEII--TGMPASTEGAYV 127
L I AS++DSG+Y K + G SA+A++ ++ S E++ T S +G++
Sbjct: 33190 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFS 33249
Query: 128 SSATSTSTT 136
S + S +
Sbjct: 33250 SQSVQMSAS 33258
Score = 49.3 bits (116), Expect = 1e-05
Identities = 48/184 (26%), Positives = 83/184 (45%), Gaps = 20/184 (10%)
Query: 15 PPR-LKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
PP+ +K++++ + A G + L C+ S ++ WF+N +EL+ K I
Sbjct: 6363 PPKFVKKLEASKVAKQGESIQLECKISGS-PEIKVSWFRNDSELHESWKYNMSFINSV-- 6419
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA---STEGAYVSS 129
+ L IN+AS DSG+Y+C+ + +G+ S S +T V++ + T P+ + +G+ V
Sbjct: 6420 -ALLTINEASAEDSGDYICEAHNGVGDASCSTALT-VKAPPVFTQKPSPVGALKGSDVIL 6477
Query: 130 ATSTSTTGTSHLV-----KCAEKEKTFCVNGGEC-----FMVKDLSNPSRYLCKCPNEFT 179
S T +V K K F + + + S+ Y CK NE
Sbjct: 6478 QCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVG 6537
Query: 180 GDRC 183
D C
Sbjct: 6538 SDTC 6541
Score = 47.8 bits (112), Expect = 3e-05
Identities = 49/206 (23%), Positives = 75/206 (36%), Gaps = 23/206 (11%)
Query: 8 RVGTTALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
+V +PP +++K +GS +V+ C+ + WF GNE++ K Q
Sbjct: 7674 QVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGS-PPISVSWFHEGNEISSGRKYQTTL 7732
Query: 67 IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAY 126
L +N +DSG+Y C + G+D SA +T+ E + P +
Sbjct: 7733 TDNT---CALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQ-KPDPMDVLT 7788
Query: 127 VSSATSTS-TTGTSHLVKCAEKEKTFCVNGGEC------------FMVKDLSNPSRYLCK 173
++ T TS GT K + V G C D S Y C
Sbjct: 7789 GTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCI 7848
Query: 174 CPNEFTGDRCQNYVM----ASFYKHL 195
NE C ++ A F K L
Sbjct: 7849 VSNEAGKASCTTHLYIKAPAKFVKRL 7874
Score = 46.6 bits (109), Expect = 7e-05
Identities = 27/98 (27%), Positives = 48/98 (48%), Gaps = 5/98 (5%)
Query: 14 LPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
+PP K++K +S GS + L C + + + +WFK+ E++ K K
Sbjct: 4673 IPPSFTKKLKKMDSIKGSFIDLECIVAGSHP-ISIQWFKDDQEISASEK---YKFSFHDN 4728
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
+ L I++ DSG Y C +K G++ S ++T+ E
Sbjct: 4729 TAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKE 4766
Score = 45.8 bits (107), Expect = 1e-04
Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 4/96 (4%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P +KE++ +SA K+ L C+ + + W K+G +L ++ KI + +
Sbjct: 3644 PHFIKELEPVQSAINKKVHLECQVDED-RKVTVTWSKDGQKLP---PGKDYKICFEDKIA 3699
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
L I A L DSG Y+C ++ G+ S SA +T+ E
Sbjct: 3700 TLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVRE 3735
Score = 45.1 bits (105), Expect = 2e-04
Identities = 46/184 (25%), Positives = 80/184 (43%), Gaps = 20/184 (10%)
Query: 15 PPR-LKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
PP+ +K++++ + AG L C+ + +R WF+N +EL +K + I
Sbjct: 5422 PPKFVKKLEASKIVKAGDSSRLECKIAGS-PEIRVVWFRNEHELPASDKYRMTFIDSV-- 5478
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE---GAYVSS 129
+ +++N S DSG+++C+ + G+ S S + IV+ + + P E A VS
Sbjct: 5479 -AVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKV-IVKEPPVFSSFPPIVETLKNAEVSL 5536
Query: 130 ATSTSTTGTSHLV--------KCAEKEKTFCVNGGECFMV--KDLSNPSRYLCKCPNEFT 179
S T +V + ++K K N + D S+ Y CK NE
Sbjct: 5537 ECELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVG 5596
Query: 180 GDRC 183
D C
Sbjct: 5597 SDTC 5600
Score = 44.7 bits (104), Expect = 3e-04
Identities = 27/78 (34%), Positives = 40/78 (51%), Gaps = 10/78 (12%)
Query: 31 KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 90
++ L+CE S + + KWFK+G E+ K I+ + L+I KA L D GEY+
Sbjct: 11679 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 11732
Query: 91 CKVISKLGNDSASANITI 108
C G D AN+T+
Sbjct: 11733 C----DCGTDKTKANVTV 11746
Score = 43.9 bits (102), Expect = 4e-04
Identities = 22/71 (30%), Positives = 36/71 (50%), Gaps = 3/71 (4%)
Query: 45 LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 104
++ WFKN EL+ N +++ ++ L I + DSG Y C+ ++ +G+DS S
Sbjct: 3767 IQVTWFKNNKELSESN---TVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCST 3823
Query: 105 NITIVESNEII 115
I I E I
Sbjct: 3824 EIVIKEPPSFI 3834
Score = 43.9 bits (102), Expect = 4e-04
Identities = 38/179 (21%), Positives = 71/179 (39%), Gaps = 23/179 (12%)
Query: 12 TALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKP 71
++ PP ++ +K+ E + L CE S W+K+ +L K KI K
Sbjct: 5520 SSFPPIVETLKNAEVS------LECELSGT-PPFEVVWYKDKRQLRSSKK---YKIASKN 5569
Query: 72 GKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSAT 131
+ + I +D GEY CK +++G+D+ + + E ++ + + T A +
Sbjct: 5570 FHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAEL 5629
Query: 132 STSTTGTSHLVKCAEKEKTFCVNGGE-------------CFMVKDLSNPSRYLCKCPNE 177
S G + KEK + E F + +N +Y+C+ N+
Sbjct: 5630 QASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKND 5688
Score = 43.9 bits (102), Expect = 4e-04
Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 5/101 (4%)
Query: 11 TTALPPRLKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 69
T PP + S A GS ++L+CE S W K+ ++ K KI
Sbjct: 6453 TVKAPPVFTQKPSPVGALKGSDVILQCEISGT-PPFEVVWVKDRKQVRNSKK---FKITS 6508
Query: 70 KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
K + L I +D GEY CK +++G+D+ S ++ E
Sbjct: 6509 KHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKE 6549
Score = 42.0 bits (97), Expect = 0.002
Identities = 27/104 (25%), Positives = 50/104 (48%), Gaps = 5/104 (4%)
Query: 8 RVGTTALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
R+ LPP +++K E G + L C + + ++ W+++G L +N++
Sbjct: 6167 RIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGS-APIQVCWYRDGVLLR---DDENLQ 6222
Query: 67 IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
+ L+I + L+ SG+Y C + LG S+SA +T E
Sbjct: 6223 TSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTARE 6266
Score = 42.0 bits (97), Expect = 0.002
Identities = 29/113 (25%), Positives = 52/113 (46%), Gaps = 13/113 (11%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P ++++K + G+ +VL C S + + WF++GNE+ K Q+
Sbjct: 6741 PSFIRKLKDVNAILGASVVLECRVSGS-APISVGWFQDGNEIVSGPKCQS---SFSENVC 6796
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIVE---------SNEIITGM 118
L ++ +D+G Y C + G+D SA +T+ E S E++ GM
Sbjct: 6797 TLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGM 6849
Score = 41.6 bits (96), Expect = 0.002
Identities = 42/177 (23%), Positives = 73/177 (41%), Gaps = 16/177 (9%)
Query: 19 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 78
KE K E ++L E + WFK+ N + R + IQ L+I
Sbjct: 4397 KEFKPIEVLKEYDVMLLAEVAGT-PPFEITWFKD-NTILRSGRKYKTFIQDH--LVSLQI 4452
Query: 79 NKASLADSGEYMCKVISKLGNDSASANITI---------VESNEIITGMPASTEGAYVSS 129
K AD+GEY C+V +++G+ SA +T+ +ES + G A+ + S
Sbjct: 4453 LKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGS 4512
Query: 130 ATSTST--TGTSHLVKCAEKEKTFCVNGGECFMVK-DLSNPSRYLCKCPNEFTGDRC 183
T T + + + TF N ++ ++ + +Y+C+ N+ RC
Sbjct: 4513 LPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRC 4569
Score = 41.6 bits (96), Expect = 0.002
Identities = 27/94 (28%), Positives = 47/94 (50%), Gaps = 4/94 (4%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P ++ ++ E+ G L+C+ +R W+K +L ++ P K+Q K +
Sbjct: 7020 PYFIEPLEHVEAVIGEPATLQCKVDGT-PEIRISWYKEHTKL--RSAPA-YKMQFKNNVA 7075
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITI 108
L INK +D GEY CK + +G ++SA + I
Sbjct: 7076 SLVINKVDHSDVGEYSCKADNSVGAVASSAVLVI 7109
Score = 41.6 bits (96), Expect = 0.002
Identities = 28/91 (30%), Positives = 46/91 (50%), Gaps = 4/91 (4%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
+++ +S + G L C T + L KWFK+G EL NK + K G L+
Sbjct: 7589 VEKPESIKVTTGDTCTLEC-TVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSG---LK 7644
Query: 78 INKASLADSGEYMCKVISKLGNDSASANITI 108
I + +DSG Y +V + +G DS +A++ +
Sbjct: 7645 IINVAPSDSGVYSFEVQNPVGKDSCTASLQV 7675
Score = 41.2 bits (95), Expect = 0.003
Identities = 28/110 (25%), Positives = 49/110 (44%), Gaps = 5/110 (4%)
Query: 2 GKGRAGRVGTTALPPR-LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
G+ G + +T PP + E++ E+A G + L+C+ + + W+K +L
Sbjct: 6065 GRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGT-PEITVSWYKGDTKLR--- 6120
Query: 61 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
+ + L NK ++ DSGEY CK + +G S+ I E
Sbjct: 6121 PTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQE 6170
Score = 40.8 bits (94), Expect = 0.004
Identities = 29/109 (26%), Positives = 51/109 (46%), Gaps = 4/109 (3%)
Query: 9 VGTTAL--PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
VG+ AL PPR + S S K V T + WFK+ E+ R++ NI
Sbjct: 7483 VGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRES--DNIW 7540
Query: 67 IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEII 115
I + L+ ++ A++G+Y C++ + G A ++++E I+
Sbjct: 7541 ISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIV 7589
Score = 40.8 bits (94), Expect = 0.004
Identities = 24/96 (25%), Positives = 46/96 (47%), Gaps = 4/96 (4%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P +K+++ + + G L+C+ + + W+K +L K+ + +
Sbjct: 7961 PYFVKQLEPVKVSVGDSASLQCQLAGT-PEIGVSWYKGDTKLRPTT---TYKMHFRNNVA 8016
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
L N+ + DSGEY+CK + +G SAS +T+ E
Sbjct: 8017 TLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQE 8052
Score = 40.8 bits (94), Expect = 0.004
Identities = 24/97 (24%), Positives = 44/97 (45%), Gaps = 7/97 (7%)
Query: 29 GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 88
G + L C +R +W K G E+ ++ G + L + + ADSG+
Sbjct: 8360 GEYVQLSCHVQGS-EPIRIQWLKAGREIKPSDR---CSFSFASGTAVLELRDVAKADSGD 8415
Query: 89 YMCKVISKLGNDSASANITIVESNEIITGMPASTEGA 125
Y+CK + G+D+ + +TI + + PA+ + A
Sbjct: 8416 YVCKASNVAGSDTTKSKVTIKDKPAV---APATKKAA 8449
Score = 40.4 bits (93), Expect = 0.005
Identities = 31/128 (24%), Positives = 57/128 (44%), Gaps = 4/128 (3%)
Query: 15 PPR-LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 73
PPR +K++ + G + LR + + W K+ E+ R++ +N +I
Sbjct: 6550 PPRFVKKLSDTSTLIGDAVELRAIVEG-FQPISVVWLKDRGEVIRES--ENTRISFIDNI 6606
Query: 74 SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATST 133
+ L++ ++SG+Y+C++ + G SA +T++E II T A
Sbjct: 6607 ATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALEC 6666
Query: 134 STTGTSHL 141
TGT L
Sbjct: 6667 VVTGTPEL 6674
Score = 40.0 bits (92), Expect = 0.006
Identities = 25/94 (26%), Positives = 39/94 (41%), Gaps = 4/94 (4%)
Query: 28 AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSG 87
AG C + +R W K+ E+ N I LRI K DSG
Sbjct: 6284 AGESADFECHVTGA-QPMRITWSKDNKEIRPGG---NYTITCVGNTPHLRILKVGKGDSG 6339
Query: 88 EYMCKVISKLGNDSASANITIVESNEIITGMPAS 121
+Y C+ + +G D SA +++ E + + + AS
Sbjct: 6340 QYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEAS 6373
Score = 39.3 bits (90), Expect = 0.011
Identities = 29/88 (32%), Positives = 41/88 (46%), Gaps = 9/88 (10%)
Query: 36 CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 95
CE S E + + KWFK+G E+ + K I K L INK L D EY C+V +
Sbjct: 12395 CELSRE--NAKVKWFKDGAEIKKGKK---YDIISKGAVRILVINKCLLDDEAEYSCEVRT 12449
Query: 96 KLGNDSASANITIVESNEIITGMPASTE 123
S +T++E + T A+ E
Sbjct: 12450 A----RTSGMLTVLEEEAVFTKNLANIE 12473
Score = 38.9 bits (89), Expect = 0.014
Identities = 20/86 (23%), Positives = 40/86 (46%), Gaps = 4/86 (4%)
Query: 25 ESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLA 84
++ G C + ++ W K+ E+ K Q ++ + L+++K
Sbjct: 8163 DAVVGESADFECHVTGT-QPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKG--- 8218
Query: 85 DSGEYMCKVISKLGNDSASANITIVE 110
DSG+Y C ++++G DS +A + I E
Sbjct: 8219 DSGQYTCYAVNEVGKDSCTAQLNIKE 8244
Score = 38.5 bits (88), Expect = 0.018
Identities = 23/63 (36%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 48 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 107
KWFK+G EL +K KI S L+I DSGEY +V + +G S A I
Sbjct: 4611 KWFKDGQELTLGSK---YKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARIN 4667
Query: 108 IVE 110
+++
Sbjct: 4668 VLD 4670
Score = 38.5 bits (88), Expect = 0.018
Identities = 23/84 (27%), Positives = 37/84 (44%), Gaps = 4/84 (4%)
Query: 25 ESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLA 84
E+ G+ + L CE W+K+ EL K KI + + + I A
Sbjct: 7409 ETLKGADVHLECELQGT-PPFHVSWYKDKRELRSGKK---YKIMSENFLTSIHILNVDAA 7464
Query: 85 DSGEYMCKVISKLGNDSASANITI 108
D GEY CK + +G+D+ +I +
Sbjct: 7465 DIGEYQCKATNDVGSDTCVGSIAL 7488
Score = 37.7 bits (86), Expect = 0.031
Identities = 26/109 (23%), Positives = 45/109 (41%), Gaps = 4/109 (3%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P + +K+ G + L C S Y S W++ ++ + +I + G +
Sbjct: 943 PTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQSGIA 998
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 123
L I +A DSG + C +++ G S S + + S E A TE
Sbjct: 999 RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1047
Score = 37.4 bits (85), Expect = 0.040
Identities = 16/60 (26%), Positives = 28/60 (46%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W+K+G ++ + + + G +L IN + D EY +K G DS A +T+
Sbjct: 31723 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 31782
Score = 37.4 bits (85), Expect = 0.040
Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 8/92 (8%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKP 71
PP++ + E+ SK + + E S LR K W+K+G +L Q
Sbjct: 32717 PPKITQFLKAEA---SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSAD 32771
Query: 72 GKSELRINKASLADSGEYMCKVISKLGNDSAS 103
G EL+IN + +D GEY+C++ + G +
Sbjct: 32772 GTYELKINNLTESDQGEYVCEISGEGGTSKTN 32803
Score = 37.0 bits (84), Expect = 0.053
Identities = 26/99 (26%), Positives = 45/99 (45%), Gaps = 6/99 (6%)
Query: 14 LPPRLKEMKSQ--ESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKP 71
+PP + S+ E G+ L + + W+KN E+ + N +I K
Sbjct: 8247 IPPSFTKRLSETVEETEGNSFKLEGRVAGS-QPITVAWYKNNIEIQPTS---NCEITFKN 8302
Query: 72 GKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
L++ KA + D+G Y CKV + G+ +++I I E
Sbjct: 8303 NTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKE 8341
Score = 36.6 bits (83), Expect = 0.069
Identities = 43/175 (24%), Positives = 69/175 (39%), Gaps = 16/175 (9%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P +K ++ + G+ +L+CE S WFK+ ++ R +K + QK
Sbjct: 3831 PSFIKTLEPADIVRGTNALLQCEVSGT-GPFEISWFKDKKQI-RSSKKYRLFSQKS--LV 3886
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIVE--------SNEIITGMPASTEGAY 126
L I + AD GEY C V +++G A + E + I G T A
Sbjct: 3887 CLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAA 3946
Query: 127 VSSATSTSTTGT--SHLVKCAEKEKTFCVNGGECFMVKD--LSNPSRYLCKCPNE 177
V + S T +++ K K NG ++ D +S +Y C NE
Sbjct: 3947 VRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENE 4001
Score = 36.6 bits (83), Expect = 0.069
Identities = 35/158 (22%), Positives = 64/158 (40%), Gaps = 23/158 (14%)
Query: 46 RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 105
+ KWFK EL ++ I + +EL + + +SG+Y C V + G+ S + +
Sbjct: 6864 KVKWFKGSRELV---PGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTH 6920
Query: 106 ITIVESNEII---------TGMPASTEGAYVSS-ATSTSTTGTSHLVKCAEK------EK 149
+ + E + TG P E Y + S S +L+ +E+ EK
Sbjct: 6921 LFVKEPATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEK 6980
Query: 150 TFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 187
+ + + + + ++Y C NE D C+ V
Sbjct: 6981 STILE----ILESTIEDYAQYSCLIENEAGQDICEALV 7014
Score = 36.2 bits (82), Expect = 0.090
Identities = 28/108 (25%), Positives = 47/108 (43%), Gaps = 5/108 (4%)
Query: 2 GKGRAGRVGTTALPPRLKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 60
G V T P R+ E + G+ L C + L KWFK+G EL+ +
Sbjct: 6631 GMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGT-PELSAKWFKDGRELSADS 6689
Query: 61 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
K I K + L+I A ++D G Y +V + +G + + ++ +
Sbjct: 6690 KHHITFINK---VASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHV 6734
Score = 36.2 bits (82), Expect = 0.090
Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 3/60 (5%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W K+G + + K K+ + G L I+K +DSG Y C V + G+ S+S +TI
Sbjct: 32885 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 32941
Score = 35.8 bits (81), Expect = 0.12
Identities = 37/181 (20%), Positives = 71/181 (39%), Gaps = 18/181 (9%)
Query: 11 TTALPPRLKEM-KSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 69
T PP E +SQ+ +++ L+ + + KWFK+ EL+ + K
Sbjct: 4763 TVKEPPYFVEKPQSQDVNPNTRVQLKALVGGT-APMTIKWFKDNKELHSGAARS---VWK 4818
Query: 70 KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEII-TGMPASTEGAYVS 128
+ L + A DSG Y+C++ + +G ++ A + + E + I P S
Sbjct: 4819 DDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQS 4878
Query: 129 SATSTSTTGTSHL----------VKCAEKEKTFCVNGGECFMVKD--LSNPSRYLCKCPN 176
+ TGT + + +K ++G F + + N Y+C+ N
Sbjct: 4879 TTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARN 4938
Query: 177 E 177
+
Sbjct: 4939 D 4939
Score = 35.8 bits (81), Expect = 0.12
Identities = 32/126 (25%), Positives = 55/126 (43%), Gaps = 11/126 (8%)
Query: 11 TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQK 69
T L P +K+ + + AG +VL + + W K G ++ +P +I +I
Sbjct: 20377 TIVLDPTIKDGLTIK--AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITS 20430
Query: 70 KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS 129
P S L I A+ D+GEY + G +T+++ + G P E + VS+
Sbjct: 20431 TPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLD----VPGPPGPVEISNVSA 20486
Query: 130 ATSTST 135
+T T
Sbjct: 20487 EKATLT 20492
Score = 35.4 bits (80), Expect = 0.15
Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)
Query: 19 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 61
K ++ Q G+ VL CE S E + + KWFKNG E+ + K
Sbjct: 12289 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 12329
Score = 35.0 bits (79), Expect = 0.20
Identities = 31/123 (25%), Positives = 53/123 (43%), Gaps = 4/123 (3%)
Query: 10 GTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 69
G A P + + Q+ G +V C+ + W K+G L + + K
Sbjct: 1077 GEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-YKVSYNK 1134
Query: 70 KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS 129
+ G+ +L I+ D+GEY V +K G SASA++ E++ M + E Y +
Sbjct: 1135 QTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADYELL--MKSQQEMLYQTQ 1192
Query: 130 ATS 132
T+
Sbjct: 1193 VTA 1195
Score = 35.0 bits (79), Expect = 0.20
Identities = 24/103 (23%), Positives = 42/103 (40%), Gaps = 5/103 (4%)
Query: 9 VGTTALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 67
V A+PP + +K+ G+ +L C+ + S + WF ++ K Q
Sbjct: 5793 VSDRAVPPSFTRRLKNTGGVLGASCILECKVAGS-SPISVAWFHEKTKIVSGAKYQTTF- 5850
Query: 68 QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 110
L++N +D G Y C + G+D A +T+ E
Sbjct: 5851 --SDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQE 5891
Score = 35.0 bits (79), Expect = 0.20
Identities = 25/93 (26%), Positives = 40/93 (43%), Gaps = 4/93 (4%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
+K + G L+L T + + W KNG + Q I + L
Sbjct: 7871 VKRLNDYSIEKGKPLILE-GTFTGTPPISVTWKKNGINVTPS---QRCNITTTEKSAILE 7926
Query: 78 INKASLADSGEYMCKVISKLGNDSASANITIVE 110
I +++ D+G+Y C + + G DS SA I I+E
Sbjct: 7927 IPSSTVEDAGQYNCYIENASGKDSCSAQILILE 7959
Score = 34.7 bits (78), Expect = 0.26
Identities = 23/99 (23%), Positives = 40/99 (40%), Gaps = 4/99 (4%)
Query: 23 SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKAS 82
S + A G +C + + ++ W K+ E+ N K+ + L + K
Sbjct: 7220 SVDLALGESGTFKCHVTGT-APIKITWAKDNREIRPGG---NYKMTLVENTATLTVLKVG 7275
Query: 83 LADSGEYMCKVISKLGNDSASANITIVESNEIITGMPAS 121
D+G+Y C + G DS SA + + E I + S
Sbjct: 7276 KGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPS 7314
Score = 34.7 bits (78), Expect = 0.26
Identities = 21/86 (24%), Positives = 42/86 (48%), Gaps = 10/86 (11%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W K+G E+ ++ + ++ + L + K+ AD+G Y + +KLG+ +AS N+ +
Sbjct: 14420 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 14476
Query: 109 VESNEIITGMPASTEGAYVSSATSTS 134
+ G+P + S T +S
Sbjct: 14477 I-------GLPGPCKDIKASDITKSS 14495
Score = 34.7 bits (78), Expect = 0.26
Identities = 22/107 (20%), Positives = 44/107 (41%), Gaps = 3/107 (2%)
Query: 8 RVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 67
+V + + P ++ G + C+ + S + W+ +L K +I
Sbjct: 31561 KVASIEIGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEK---YEI 31617
Query: 68 QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEI 114
+ G + L + + D G Y CKV++ G DS+ A + + E+
Sbjct: 31618 TYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREV 31664
Score = 34.3 bits (77), Expect = 0.34
Identities = 25/110 (22%), Positives = 42/110 (38%), Gaps = 4/110 (3%)
Query: 29 GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 88
G C+ + +R W+ +GNE+ K I G + +I+ A + +SG
Sbjct: 4876 GQSTTFECQITGT-PKIRVSWYLDGNEITAIQKHG---ISFIDGLATFQISGARVENSGT 4931
Query: 89 YMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATSTSTTGT 138
Y+C+ + G S S + + E I + Y TGT
Sbjct: 4932 YVCEARNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGT 4981
Score = 34.3 bits (77), Expect = 0.34
Identities = 33/152 (21%), Positives = 61/152 (40%), Gaps = 17/152 (11%)
Query: 45 LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 104
++ W+K+ E+ +K ++ + L ++ S+ DSG+Y C+ + G+ S+S
Sbjct: 7335 IKVLWYKDETEIQESSK---FRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSST 7391
Query: 105 NITIVESNEIITGMPASTE---GAYVSSATSTSTTGTSHL--------VKCAEKEKTFCV 153
++ + E I P E GA V T H+ ++ +K K
Sbjct: 7392 SLKVKEP-PIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSE 7450
Query: 154 NGGECFMV--KDLSNPSRYLCKCPNEFTGDRC 183
N + D ++ Y CK N+ D C
Sbjct: 7451 NFLTSIHILNVDAADIGEYQCKATNDVGSDTC 7482
Score = 33.9 bits (76), Expect = 0.45
Identities = 25/102 (24%), Positives = 49/102 (48%), Gaps = 4/102 (3%)
Query: 15 PPR-LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 73
PPR + ++ S AG L+ + +W K E+ R++ +NI+I
Sbjct: 5609 PPRFVSKLNSLTVVAGEPAELQASIEGA-QPIFVQWLKEKEEVIRES--ENIRITFVENV 5665
Query: 74 SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEII 115
+ L+ KA A++G+Y+C++ + G A + ++E I+
Sbjct: 5666 ATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIV 5707
Score = 33.5 bits (75), Expect = 0.58
Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 3/76 (3%)
Query: 46 RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 105
+ KWFK+ EL K I + S L + + +G+Y C V + +G+DS +
Sbjct: 5360 KIKWFKDDVELVSGPK---CFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTM 5416
Query: 106 ITIVESNEIITGMPAS 121
+ + E + + + AS
Sbjct: 5417 LLVTEPPKFVKKLEAS 5432
Score = 33.1 bits (74), Expect = 0.76
Identities = 31/171 (18%), Positives = 64/171 (37%), Gaps = 16/171 (9%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK + G ++L T + + W K+G + K + +K L
Sbjct: 5989 LKRLSDHSVEPGKSIILE-STYTGTLPISVTWKKDGFNITTSEKCNIVTTEKT---CILE 6044
Query: 78 INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATSTSTTG 137
I ++ D+G+Y C++ ++ G D A ++ +E +T + S + G
Sbjct: 6045 ILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAG 6104
Query: 138 TSHL----------VKCAEKEKTFCVNGGE--CFMVKDLSNPSRYLCKCPN 176
T + ++ + +T+ N F ++++ Y CK N
Sbjct: 6105 TPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAEN 6155
Score = 33.1 bits (74), Expect = 0.76
Identities = 26/96 (27%), Positives = 44/96 (45%), Gaps = 11/96 (11%)
Query: 18 LKEMK----SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 73
+KE+K ++ GS + C S S+ W K+G+ + K + I K
Sbjct: 11118 VKEIKDIILTESEFVGSSAIFECLVSP--STAITTWMKDGSNIRESPKHRFIADGKD--- 11172
Query: 74 SELRINKASLADSGEYMCKVISKLGNDSASANITIV 109
+L I L+D+GEY C + +LGN ++ +V
Sbjct: 11173 RKLHIIDVQLSDAGEYTC--VLRLGNKEKTSTAKLV 11206
Score = 32.7 bits (73), Expect = 0.99
Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 8/97 (8%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK+ + +E ++V CE ++E + KWF+N + +K I +K LR
Sbjct: 12646 LKDTRVKEQ---QEVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQKDLVYTLR 12697
Query: 78 INKASLADSGEYMCKVISKLGNDSASANITIVESNEI 114
I A L D Y + + G + SA IVE ++
Sbjct: 12698 IRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDL 12734
Score = 32.7 bits (73), Expect = 0.99
Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
++ ++ Q V C+ S E +++ KW++NG E+ K K +K L
Sbjct: 12826 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 12880
Query: 78 INKASLADSGEYMCKV 93
I L D EY C V
Sbjct: 12881 IKDCRLDDECEYACGV 12896
Score = 32.0 bits (71), Expect = 1.7
Identities = 23/75 (30%), Positives = 33/75 (44%), Gaps = 5/75 (6%)
Query: 19 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 78
K + Q A + V CE ++ S + +W ++G L N NI+ + K L I
Sbjct: 2624 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2678
Query: 79 NKASLADSGEYMCKV 93
L D GEY KV
Sbjct: 2679 AATKLDDIGEYTYKV 2693
Score = 32.0 bits (71), Expect = 1.7
Identities = 30/150 (20%), Positives = 59/150 (39%), Gaps = 15/150 (10%)
Query: 46 RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 105
+ WF+ EL + ++ I + +EL + ++ SGEY C V + G S +
Sbjct: 5923 KVNWFRGARELVKGDR---CNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTR 5979
Query: 106 ITIVESNEIITGMPASTEGAYVSSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVK--- 162
+ + E + + + S ++ TGT + +K+ +C +V
Sbjct: 5980 LFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEK 6039
Query: 163 ----DLSNPSR-----YLCKCPNEFTGDRC 183
++ N ++ Y C+ NE D C
Sbjct: 6040 TCILEILNSTKRDAGQYSCEIENEAGRDVC 6069
Score = 32.0 bits (71), Expect = 1.7
Identities = 24/102 (23%), Positives = 46/102 (45%), Gaps = 3/102 (2%)
Query: 8 RVGTTALPPRLKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
+ G +PP+++ + S S G L + C + E + W G +++ + + +
Sbjct: 33321 KAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FH 33378
Query: 67 IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
I+ + L I D G Y + ++ G+DSA+ NI I
Sbjct: 33379 IENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 33420
Score = 31.6 bits (70), Expect = 2.2
Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 8/72 (11%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK++ ++E K + E + Y + +KW KNG E+ +K Q ++ K L
Sbjct: 2975 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 3026
Query: 78 INKASLADSGEY 89
I D+ +Y
Sbjct: 3027 IRNVHFGDAADY 3038
Score = 31.6 bits (70), Expect = 2.2
Identities = 40/171 (23%), Positives = 62/171 (36%), Gaps = 19/171 (11%)
Query: 29 GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 88
G L C+ + L +W+K+G L K + K S LRI D+G
Sbjct: 5718 GETCTLECKVAGT-PELSVEWYKDGKLLTSSQKHKFSFYNKI---SSLRILSVERQDAGT 5773
Query: 89 YMCKVISKLGNDSASANITIVES--NEIITGMPASTEGAY-VSSATSTSTTGTSHLVKCA 145
Y +V + +G S +A + + + T +T G S G+S +
Sbjct: 5774 YTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAW 5833
Query: 146 EKEKTFCVNGGE---------CFM---VKDLSNPSRYLCKCPNEFTGDRCQ 184
EKT V+G + C + D S+ Y C N D C+
Sbjct: 5834 FHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECR 5884
Score = 30.4 bits (67), Expect = 4.9
Identities = 16/68 (23%), Positives = 30/68 (44%), Gaps = 3/68 (4%)
Query: 48 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 107
+W +G L N+ +++ + G L A DSG C+ +K G D SA +
Sbjct: 1737 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1793
Query: 108 IVESNEII 115
+ + ++
Sbjct: 1794 VKDEKSLV 1801
Score = 30.0 bits (66), Expect = 6.4
Identities = 22/100 (22%), Positives = 47/100 (47%), Gaps = 12/100 (12%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK++ ++E + V E S + ++R KWFKN L + +++ +Q + +
Sbjct: 11935 LKDVTAKEKESA---VFTVELS--HDNIRVKWFKNDQRL---HTTRSVSMQDEGKTHSIT 11986
Query: 78 INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITG 117
S+ D+ + + + S+ A +T++E + TG
Sbjct: 11987 FKDLSIDDTSQIRVEAMGM----SSEAKLTVLEGDPYFTG 12022
Score = 29.6 bits (65), Expect = 8.4
Identities = 16/63 (25%), Positives = 31/63 (49%), Gaps = 2/63 (3%)
Query: 48 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 107
KW K + + N+ + I +K +++L I + DSG Y C ++ G ++ N+
Sbjct: 8486 KWTKG--KWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQ 8543
Query: 108 IVE 110
+ E
Sbjct: 8544 VDE 8546
Score = 29.6 bits (65), Expect = 8.4
Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W K+ + + P+ +KI + S+ + KA +D G+Y+ + G+ A A + +
Sbjct: 18235 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 18293
Query: 109 VE 110
++
Sbjct: 18294 LD 18295
>gi|221316757 neurotrimin isoform 3 [Homo sapiens]
Length = 355
Score = 52.4 bits (124), Expect = 1e-06
Identities = 40/134 (29%), Positives = 59/134 (44%), Gaps = 11/134 (8%)
Query: 11 TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 70
T PP + E K G K L+CE S+ S F+W+K+ L K +K++ +
Sbjct: 218 TVNYPPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENR 274
Query: 71 PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSA 130
P S+L S D G Y C +KLG+ +AS + V++ + P G A
Sbjct: 275 PFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFEVKTTAL---TPWKGPG-----A 326
Query: 131 TSTSTTGTSHLVKC 144
S + GTS C
Sbjct: 327 VSEVSNGTSRRAGC 340
>gi|45594240 limbic system-associated membrane protein [Homo
sapiens]
Length = 338
Score = 51.6 bits (122), Expect = 2e-06
Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 4/93 (4%)
Query: 11 TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 70
T PP + E KS E+ G + L+CE S+ + F+W+++ +N N ++I+
Sbjct: 214 TVNYPPTITESKSNEATTGRQASLKCEASA-VPAPDFEWYRDDTRINSAN---GLEIKST 269
Query: 71 PGKSELRINKASLADSGEYMCKVISKLGNDSAS 103
G+S L + + G Y C +KLG +AS
Sbjct: 270 EGQSSLTVTNVTEEHYGNYTCVAANKLGVTNAS 302
>gi|221316762 neurotrimin isoform 4 [Homo sapiens]
Length = 316
Score = 51.2 bits (121), Expect = 3e-06
Identities = 31/93 (33%), Positives = 45/93 (48%), Gaps = 3/93 (3%)
Query: 11 TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 70
T PP + E K G K L+CE S+ S F+W+K+ L K +K++ +
Sbjct: 218 TVNYPPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENR 274
Query: 71 PGKSELRINKASLADSGEYMCKVISKLGNDSAS 103
P S+L S D G Y C +KLG+ +AS
Sbjct: 275 PFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS 307
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 51.2 bits (121), Expect = 3e-06
Identities = 41/147 (27%), Positives = 62/147 (42%), Gaps = 15/147 (10%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
PP E S A G L L+C + + + W K G L +++
Sbjct: 2827 PPIRIEPSSSRVAEGQTLDLKCVVPGQ-AHAQVTWHKRGGNLPARHQVHG---------P 2876
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATSTS 134
LR+N+ S ADSGEY C+V G AS +TI S+ P + Y+ +++S
Sbjct: 2877 LLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHV 2936
Query: 135 TTGTSHLVKC-----AEKEKTFCVNGG 156
T G + + C A + T+ GG
Sbjct: 2937 TEGQTLDLNCVVPGQAHAQVTWYKRGG 2963
Score = 47.0 bits (110), Expect = 5e-05
Identities = 31/104 (29%), Positives = 49/104 (47%), Gaps = 11/104 (10%)
Query: 6 AGRVGTTALPPRLK-EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQN 64
AG V + P ++ E S + A G L L C + + + + W K G L +++
Sbjct: 2427 AGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQ-AHAQVTWHKRGGSLPARHQVHG 2485
Query: 65 IKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
S LR+ + + ADSGEY+C+V+ G AS +TI
Sbjct: 2486 ---------SRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTI 2520
Score = 45.8 bits (107), Expect = 1e-04
Identities = 37/136 (27%), Positives = 61/136 (44%), Gaps = 14/136 (10%)
Query: 13 ALPPRLK-EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKP 71
A PP +K E S G L L C + + + W++ G L P + ++
Sbjct: 2048 ASPPPVKIESSSPSVTEGQTLDLNCVVAGS-AHAQVTWYRRGGSL-----PPHTQVHG-- 2099
Query: 72 GKSELRINKASLADSGEYMCKVISKLGNDSASANITIV---ESNEIITGMPASTEGAYVS 128
S LR+ + S ADSGEY+C+V + G AS ++++ S T +P ST +
Sbjct: 2100 --SRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIE 2157
Query: 129 SATSTSTTGTSHLVKC 144
++S G + + C
Sbjct: 2158 PSSSHVAEGQTLDLNC 2173
Score = 45.8 bits (107), Expect = 1e-04
Identities = 33/109 (30%), Positives = 50/109 (45%), Gaps = 11/109 (10%)
Query: 12 TALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKP 71
+++P R+ E S A G L L C + + + W K G L ++ +
Sbjct: 2725 SSMPIRI-ESSSSHVAEGETLDLNCVVPGQ-AHAQVTWHKRGGSLPSHHQTRG------- 2775
Query: 72 GKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 120
S LR++ S ADSGEY+C+V+ G AS +TI S +PA
Sbjct: 2776 --SRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPA 2822
Score = 43.9 bits (102), Expect = 4e-04
Identities = 35/130 (26%), Positives = 60/130 (46%), Gaps = 20/130 (15%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
PP E S G L L C + + ++ W+K G L +++ S
Sbjct: 2630 PPIRIESSSPTVVEGQTLDLNCVVARQPQAI-ITWYKRGGSLPSRHQTHG---------S 2679
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMP-ASTEGAYVSSATST 133
LR+++ S+ADSGEY+C+ A+ NI +E++ +I+ P A + A SS
Sbjct: 2680 HLRLHQMSVADSGEYVCR---------ANNNIDALEASIVISVSPSAGSPSAPGSSMPIR 2730
Query: 134 STTGTSHLVK 143
+ +SH+ +
Sbjct: 2731 IESSSSHVAE 2740
Score = 42.7 bits (99), Expect = 0.001
Identities = 38/142 (26%), Positives = 59/142 (41%), Gaps = 20/142 (14%)
Query: 20 EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRIN 79
E S A G L L C + + + W K G L +++ S LR++
Sbjct: 2157 EPSSSHVAEGQTLDLNCVVPGQ-AHAQVTWHKRGGSLPARHQTHG---------SLLRLH 2206
Query: 80 KASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATSTSTTGTS 139
+ + ADSGEY+C V+ G AS +TI S +P + S++ST G +
Sbjct: 2207 QVTPADSGEYVCHVVGTSGPLEASVLVTIEAS-----VIPGPIPPVRIESSSSTVAEGQT 2261
Query: 140 HLVKC-----AEKEKTFCVNGG 156
+ C A + T+ GG
Sbjct: 2262 LDLSCVVAGQAHAQVTWYKRGG 2283
Score = 42.7 bits (99), Expect = 0.001
Identities = 37/132 (28%), Positives = 60/132 (45%), Gaps = 13/132 (9%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
A P R+ E S A G L L C +S+ + W+K G L +++
Sbjct: 2533 AYPVRI-ESSSASLANGHTLDLNCLVASQ-APHTITWYKRGGSLPSRHQIVG-------- 2582
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATS 132
S LRI + + ADSGEY+C V + G+ S +TI S + +P+ + + S++
Sbjct: 2583 -SRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGS--SHVPSVSPPIRIESSSP 2639
Query: 133 TSTTGTSHLVKC 144
T G + + C
Sbjct: 2640 TVVEGQTLDLNC 2651
Score = 40.8 bits (94), Expect = 0.004
Identities = 20/49 (40%), Positives = 26/49 (53%), Gaps = 7/49 (14%)
Query: 137 GTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQN 185
G SH C ++ C NGG+C S S Y+C CP FTG RC++
Sbjct: 3841 GISHCPTCRDRP---CQNGGQCHD----SESSSYVCVCPAGFTGSRCEH 3882
Score = 40.4 bits (93), Expect = 0.005
Identities = 33/132 (25%), Positives = 59/132 (44%), Gaps = 14/132 (10%)
Query: 14 LPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 73
+PP E S A G L L C + + + + W+K G L +++ +
Sbjct: 2244 IPPVRIESSSSTVAEGQTLDLSCVVAGQ-AHAQVTWYKRGGSLPARHQVRG--------- 2293
Query: 74 SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA-STEGAYVSSATS 132
S L I +AS AD+G+Y+C+ + + AS +T+ + PA ST+ + ++S
Sbjct: 2294 SRLYIFQASPADAGQYVCRASNGM---EASITVTVTGTQGANLAYPAGSTQPIRIEPSSS 2350
Query: 133 TSTTGTSHLVKC 144
G + + C
Sbjct: 2351 QVAEGQTLDLNC 2362
Score = 40.4 bits (93), Expect = 0.005
Identities = 29/95 (30%), Positives = 43/95 (45%), Gaps = 10/95 (10%)
Query: 20 EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRIN 79
E S + A G L L C + S + W K G L +++ S LR+
Sbjct: 2346 EPSSSQVAEGQTLDLNCVVPGQ-SHAQVTWHKRGGSLPVRHQTHG---------SLLRLY 2395
Query: 80 KASLADSGEYMCKVISKLGNDSASANITIVESNEI 114
+AS ADSGEY+C+V+ AS +TI + +
Sbjct: 2396 QASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSV 2430
Score = 38.9 bits (89), Expect = 0.014
Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 11/93 (11%)
Query: 20 EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRIN 79
E S G L L C + + + W+K G L +++ S+LR++
Sbjct: 2930 EASSSHVTEGQTLDLNCVVPGQ-AHAQVTWYKRGGSLPARHQTHG---------SQLRLH 2979
Query: 80 KASLADSGEYMCKVISKLG-NDSASANITIVES 111
S ADSGEY+C+ S G AS +T+ S
Sbjct: 2980 LVSPADSGEYVCRAASGPGPEQEASFTVTVPPS 3012
Score = 37.4 bits (85), Expect = 0.040
Identities = 33/121 (27%), Positives = 52/121 (42%), Gaps = 13/121 (10%)
Query: 28 AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSG 87
AG + L+C L F+W + G+ L + +N L +A+ DSG
Sbjct: 3312 AGETVQLQCLAHGT-PPLTFQWSRVGSSLPGRATARN---------ELLHFERAAPEDSG 3361
Query: 88 EYMCKVISKLGNDSASANITI--VESNEIITGMPA-STEGAYVSSATSTSTTGTSHLVKC 144
Y C+V +K+G+ A A + + + T +PA ST V+ T + G S C
Sbjct: 3362 RYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHC 3421
Query: 145 A 145
A
Sbjct: 3422 A 3422
Score = 35.8 bits (81), Expect = 0.12
Identities = 28/125 (22%), Positives = 49/125 (39%), Gaps = 15/125 (12%)
Query: 6 AGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI 65
AG T + P+L + + G+ + C S+ + + +WFK G +L + Q+
Sbjct: 3396 AGSTPTVQVTPQL-----ETKSIGASVEFHCAVPSDRGT-QLRWFKEGGQLPPGHSVQD- 3448
Query: 66 KIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGA 125
LRI + G Y+C+ G ASA + I ++ + S +
Sbjct: 3449 --------GVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTV 3500
Query: 126 YVSSA 130
V A
Sbjct: 3501 VVGHA 3505
Score = 30.4 bits (67), Expect = 4.9
Identities = 29/117 (24%), Positives = 49/117 (41%), Gaps = 13/117 (11%)
Query: 28 AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSG 87
AG + L C + S W K G L + + + I + L I + AD+G
Sbjct: 1969 AGRTVRLYCRAAG-VPSATITWRKEGGSLPPQARSERTDI------ATLLIPAITTADAG 2021
Query: 88 EYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATSTSTTGTSHLVKC 144
Y+C S G +A A I +V +++ AS + S++ + T G + + C
Sbjct: 2022 FYLCVATSPAG--TAQARIQVV----VLSASDASPPPVKIESSSPSVTEGQTLDLNC 2072
Score = 29.6 bits (65), Expect = 8.4
Identities = 29/115 (25%), Positives = 50/115 (43%), Gaps = 15/115 (13%)
Query: 9 VGTTALPPRLKEMKSQESA----AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQN 64
V T A+ P +++++E+ AG LRC + + W K + L +++ +
Sbjct: 3202 VDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPT-IHWSKLRSPLPWQHRLEG 3260
Query: 65 IKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMP 119
L I + + DSG+Y+C S G+ A+ I VES T +P
Sbjct: 3261 ---------DTLIIPRVAQQDSGQYICNATSPAGHAEATI-ILHVESPPYATTVP 3305
>gi|115298665 neurotrimin isoform 2 [Homo sapiens]
Length = 344
Score = 51.2 bits (121), Expect = 3e-06
Identities = 31/93 (33%), Positives = 45/93 (48%), Gaps = 3/93 (3%)
Query: 11 TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 70
T PP + E K G K L+CE S+ S F+W+K+ L K +K++ +
Sbjct: 218 TVNYPPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENR 274
Query: 71 PGKSELRINKASLADSGEYMCKVISKLGNDSAS 103
P S+L S D G Y C +KLG+ +AS
Sbjct: 275 PFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS 307
>gi|7705413 neurotrimin isoform 1 [Homo sapiens]
Length = 344
Score = 51.2 bits (121), Expect = 3e-06
Identities = 31/93 (33%), Positives = 45/93 (48%), Gaps = 3/93 (3%)
Query: 11 TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 70
T PP + E K G K L+CE S+ S F+W+K+ L K +K++ +
Sbjct: 218 TVNYPPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENR 274
Query: 71 PGKSELRINKASLADSGEYMCKVISKLGNDSAS 103
P S+L S D G Y C +KLG+ +AS
Sbjct: 275 PFLSKLIFFNVSEHDYGNYTCVASNKLGHTNAS 307
>gi|110349717 titin isoform novex-2 [Homo sapiens]
Length = 27118
Score = 49.7 bits (117), Expect = 8e-06
Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 4/96 (4%)
Query: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
A P ++++ E A G CE S ++RF+WFK G E+ +K I+
Sbjct: 4527 AAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIYESDK---CSIRSSKY 4582
Query: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
S L I + + D GEY CK ++ G+ S +A +T+
Sbjct: 4583 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4618
Score = 49.7 bits (117), Expect = 8e-06
Identities = 35/129 (27%), Positives = 62/129 (48%), Gaps = 11/129 (8%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P + + +SQ G ++ CE S E S +WFKN ++ + N+ I +
Sbjct: 26829 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 26884
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIV-----ESNEII--TGMPASTEGAYV 127
L I AS++DSG+Y K + G SA+A++ ++ S E++ T S +G++
Sbjct: 26885 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFS 26944
Query: 128 SSATSTSTT 136
S + S +
Sbjct: 26945 SQSVQMSAS 26953
Score = 44.7 bits (104), Expect = 3e-04
Identities = 27/78 (34%), Positives = 40/78 (51%), Gaps = 10/78 (12%)
Query: 31 KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 90
++ L+CE S + + KWFK+G E+ K I+ + L+I KA L D GEY+
Sbjct: 5374 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 5427
Query: 91 CKVISKLGNDSASANITI 108
C G D AN+T+
Sbjct: 5428 C----DCGTDKTKANVTV 5441
Score = 39.3 bits (90), Expect = 0.011
Identities = 29/88 (32%), Positives = 41/88 (46%), Gaps = 9/88 (10%)
Query: 36 CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 95
CE S E + + KWFK+G E+ + K I K L INK L D EY C+V +
Sbjct: 6090 CELSRE--NAKVKWFKDGAEIKKGKK---YDIISKGAVRILVINKCLLDDEAEYSCEVRT 6144
Query: 96 KLGNDSASANITIVESNEIITGMPASTE 123
S +T++E + T A+ E
Sbjct: 6145 A----RTSGMLTVLEEEAVFTKNLANIE 6168
Score = 37.7 bits (86), Expect = 0.031
Identities = 26/109 (23%), Positives = 45/109 (41%), Gaps = 4/109 (3%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 74
P + +K+ G + L C S Y S W++ ++ + +I + G +
Sbjct: 897 PTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQSGIA 952
Query: 75 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 123
L I +A DSG + C +++ G S S + + S E A TE
Sbjct: 953 RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1001
Score = 37.4 bits (85), Expect = 0.040
Identities = 16/60 (26%), Positives = 28/60 (46%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W+K+G ++ + + + G +L IN + D EY +K G DS A +T+
Sbjct: 25418 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25477
Score = 37.4 bits (85), Expect = 0.040
Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 8/92 (8%)
Query: 15 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKP 71
PP++ + E+ SK + + E S LR K W+K+G +L Q
Sbjct: 26412 PPKITQFLKAEA---SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSAD 26466
Query: 72 GKSELRINKASLADSGEYMCKVISKLGNDSAS 103
G EL+IN + +D GEY+C++ + G +
Sbjct: 26467 GTYELKINNLTESDQGEYVCEISGEGGTSKTN 26498
Score = 36.2 bits (82), Expect = 0.090
Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 3/60 (5%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W K+G + + K K+ + G L I+K +DSG Y C V + G+ S+S +TI
Sbjct: 26580 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26636
Score = 35.8 bits (81), Expect = 0.12
Identities = 32/126 (25%), Positives = 55/126 (43%), Gaps = 11/126 (8%)
Query: 11 TTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQK 69
T L P +K+ + + AG +VL + + W K G ++ +P +I +I
Sbjct: 14072 TIVLDPTIKDGLTIK--AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITS 14125
Query: 70 KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS 129
P S L I A+ D+GEY + G +T+++ + G P E + VS+
Sbjct: 14126 TPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLD----VPGPPGPVEISNVSA 14181
Query: 130 ATSTST 135
+T T
Sbjct: 14182 EKATLT 14187
Score = 35.4 bits (80), Expect = 0.15
Identities = 27/116 (23%), Positives = 44/116 (37%), Gaps = 3/116 (2%)
Query: 8 RVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 67
++G P LKE+K A G + E + WFK +L I
Sbjct: 3760 KLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPT-VTWFKENKQLC--TSVYYTII 3816
Query: 68 QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 123
G +N DSG Y+CK + LG + +A + ++ + +T P +
Sbjct: 3817 HNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDTPCKAK 3872
Score = 35.4 bits (80), Expect = 0.15
Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)
Query: 19 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 61
K ++ Q G+ VL CE S E + + KWFKNG E+ + K
Sbjct: 5984 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 6024
Score = 35.0 bits (79), Expect = 0.20
Identities = 31/123 (25%), Positives = 53/123 (43%), Gaps = 4/123 (3%)
Query: 10 GTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 69
G A P + + Q+ G +V C+ + W K+G L + + K
Sbjct: 1031 GEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-YKVSYNK 1088
Query: 70 KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS 129
+ G+ +L I+ D+GEY V +K G SASA++ E++ M + E Y +
Sbjct: 1089 QTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADYELL--MKSQQEMLYQTQ 1146
Query: 130 ATS 132
T+
Sbjct: 1147 VTA 1149
Score = 34.7 bits (78), Expect = 0.26
Identities = 21/86 (24%), Positives = 42/86 (48%), Gaps = 10/86 (11%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W K+G E+ ++ + ++ + L + K+ AD+G Y + +KLG+ +AS N+ +
Sbjct: 8115 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 8171
Query: 109 VESNEIITGMPASTEGAYVSSATSTS 134
+ G+P + S T +S
Sbjct: 8172 I-------GLPGPCKDIKASDITKSS 8190
Score = 34.7 bits (78), Expect = 0.26
Identities = 22/107 (20%), Positives = 44/107 (41%), Gaps = 3/107 (2%)
Query: 8 RVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 67
+V + + P ++ G + C+ + S + W+ +L K +I
Sbjct: 25256 KVASIEIGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEK---YEI 25312
Query: 68 QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEI 114
+ G + L + + D G Y CKV++ G DS+ A + + E+
Sbjct: 25313 TYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREV 25359
Score = 33.1 bits (74), Expect = 0.76
Identities = 26/96 (27%), Positives = 44/96 (45%), Gaps = 11/96 (11%)
Query: 18 LKEMK----SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 73
+KE+K ++ GS + C S S+ W K+G+ + K + I K
Sbjct: 4813 VKEIKDIILTESEFVGSSAIFECLVSP--STAITTWMKDGSNIRESPKHRFIADGKD--- 4867
Query: 74 SELRINKASLADSGEYMCKVISKLGNDSASANITIV 109
+L I L+D+GEY C + +LGN ++ +V
Sbjct: 4868 RKLHIIDVQLSDAGEYTC--VLRLGNKEKTSTAKLV 4901
Score = 32.7 bits (73), Expect = 0.99
Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 8/97 (8%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK+ + +E ++V CE ++E + KWF+N + +K I +K LR
Sbjct: 6341 LKDTRVKEQ---QEVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQKDLVYTLR 6392
Query: 78 INKASLADSGEYMCKVISKLGNDSASANITIVESNEI 114
I A L D Y + + G + SA IVE ++
Sbjct: 6393 IRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDL 6429
Score = 32.7 bits (73), Expect = 0.99
Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
++ ++ Q V C+ S E +++ KW++NG E+ K K +K L
Sbjct: 6521 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 6575
Query: 78 INKASLADSGEYMCKV 93
I L D EY C V
Sbjct: 6576 IKDCRLDDECEYACGV 6591
Score = 32.0 bits (71), Expect = 1.7
Identities = 23/75 (30%), Positives = 33/75 (44%), Gaps = 5/75 (6%)
Query: 19 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 78
K + Q A + V CE ++ S + +W ++G L N NI+ + K L I
Sbjct: 2578 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2632
Query: 79 NKASLADSGEYMCKV 93
L D GEY KV
Sbjct: 2633 AATKLDDIGEYTYKV 2647
Score = 32.0 bits (71), Expect = 1.7
Identities = 24/102 (23%), Positives = 46/102 (45%), Gaps = 3/102 (2%)
Query: 8 RVGTTALPPRLKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIK 66
+ G +PP+++ + S S G L + C + E + W G +++ + + +
Sbjct: 27016 KAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FH 27073
Query: 67 IQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
I+ + L I D G Y + ++ G+DSA+ NI I
Sbjct: 27074 IENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 27115
Score = 31.6 bits (70), Expect = 2.2
Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 8/72 (11%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK++ ++E K + E + Y + +KW KNG E+ +K Q ++ K L
Sbjct: 2929 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 2980
Query: 78 INKASLADSGEY 89
I D+ +Y
Sbjct: 2981 IRNVHFGDAADY 2992
Score = 30.4 bits (67), Expect = 4.9
Identities = 16/68 (23%), Positives = 30/68 (44%), Gaps = 3/68 (4%)
Query: 48 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 107
+W +G L N+ +++ + G L A DSG C+ +K G D SA +
Sbjct: 1691 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1747
Query: 108 IVESNEII 115
+ + ++
Sbjct: 1748 VKDEKSLV 1755
Score = 30.0 bits (66), Expect = 6.4
Identities = 22/100 (22%), Positives = 47/100 (47%), Gaps = 12/100 (12%)
Query: 18 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 77
LK++ ++E + V E S + ++R KWFKN L + +++ +Q + +
Sbjct: 5630 LKDVTAKEKESA---VFTVELS--HDNIRVKWFKNDQRL---HTTRSVSMQDEGKTHSIT 5681
Query: 78 INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITG 117
S+ D+ + + + S+ A +T++E + TG
Sbjct: 5682 FKDLSIDDTSQIRVEAMGM----SSEAKLTVLEGDPYFTG 5717
Score = 29.6 bits (65), Expect = 8.4
Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)
Query: 49 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 108
W K+ + + P+ +KI + S+ + KA +D G+Y+ + G+ A A + +
Sbjct: 11930 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 11988
Query: 109 VE 110
++
Sbjct: 11989 LD 11990
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.125 0.359
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,134,243
Number of Sequences: 37866
Number of extensions: 1241539
Number of successful extensions: 7787
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 446
Number of HSP's that attempted gapping in prelim test: 5900
Number of HSP's gapped (non-prelim): 2154
length of query: 607
length of database: 18,247,518
effective HSP length: 108
effective length of query: 499
effective length of database: 14,157,990
effective search space: 7064837010
effective search space used: 7064837010
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.