Search of human proteins with 23397663

Search of human proteins with 23397663

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|23397663 alpha/beta hydrolase domain containing protein 3
[Homo sapiens]
         (409 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|23397663 alpha/beta hydrolase domain containing protein 3 [Ho...   840   0.0  
gi|194578891 abhydrolase domain-containing protein 1 [Homo sapiens]   359   2e-99
gi|23397659 alpha/beta hydrolase domain containing protein 2 [Ho...   134   1e-31
gi|23397661 alpha/beta hydrolase domain containing protein 2 [Ho...   134   1e-31
gi|39930569 abhydrolase domain containing 15 [Homo sapiens]           111   1e-24
gi|109689718 abhydrolase domain containing 12 isoform a [Homo sa...    32   1.0  
gi|24308097 abhydrolase domain containing 12 isoform b [Homo sap...    32   1.0  
gi|190341095 transmembrane protein 63C [Homo sapiens]                  31   2.3  
gi|8923001 abhydrolase domain containing 10 [Homo sapiens]             30   3.0  
gi|45439359 triple functional domain (PTPRF interacting) [Homo s...    30   5.2  
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]           29   6.7  
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]             29   6.7  
gi|8922549 anti-silencing function 1B [Homo sapiens]                   29   6.7  

>gi|23397663 alpha/beta hydrolase domain containing protein 3 [Homo
           sapiens]
          Length = 409

 Score =  840 bits (2171), Expect = 0.0
 Identities = 409/409 (100%), Positives = 409/409 (100%)

Query: 1   MQRLAMDLRMLSRELSLYLEHQVRVGFFGSGVGLSLILGFSVAYAFYYLSSIAKKPQLVT 60
           MQRLAMDLRMLSRELSLYLEHQVRVGFFGSGVGLSLILGFSVAYAFYYLSSIAKKPQLVT
Sbjct: 1   MQRLAMDLRMLSRELSLYLEHQVRVGFFGSGVGLSLILGFSVAYAFYYLSSIAKKPQLVT 60

Query: 61  GGESFSRFLQDHCPVVTETYYPTVWCWEGRGQTLLRPFITSKPPVQYRNELIKTADGGQI 120
           GGESFSRFLQDHCPVVTETYYPTVWCWEGRGQTLLRPFITSKPPVQYRNELIKTADGGQI
Sbjct: 61  GGESFSRFLQDHCPVVTETYYPTVWCWEGRGQTLLRPFITSKPPVQYRNELIKTADGGQI 120

Query: 121 SLDWFDNDNSTCYMDASTRPTILLLPGLTGTSKESYILHMIHLSEELGYRCVVFNNRGVA 180
           SLDWFDNDNSTCYMDASTRPTILLLPGLTGTSKESYILHMIHLSEELGYRCVVFNNRGVA
Sbjct: 121 SLDWFDNDNSTCYMDASTRPTILLLPGLTGTSKESYILHMIHLSEELGYRCVVFNNRGVA 180

Query: 181 GENLLTPRTYCCANTEDLETVIHHVHSLYPSAPFLAAGVSMGGMLLLNYLGKIGSKTPLM 240
           GENLLTPRTYCCANTEDLETVIHHVHSLYPSAPFLAAGVSMGGMLLLNYLGKIGSKTPLM
Sbjct: 181 GENLLTPRTYCCANTEDLETVIHHVHSLYPSAPFLAAGVSMGGMLLLNYLGKIGSKTPLM 240

Query: 241 AAATFSVGWNTFACSESLEKPLNWLLFNYYLTTCLQSSVNKHRHMFVKQVDMDHVMKAKS 300
           AAATFSVGWNTFACSESLEKPLNWLLFNYYLTTCLQSSVNKHRHMFVKQVDMDHVMKAKS
Sbjct: 241 AAATFSVGWNTFACSESLEKPLNWLLFNYYLTTCLQSSVNKHRHMFVKQVDMDHVMKAKS 300

Query: 301 IREFDKRFTSVMFGYQTIDDYYTDASPSPRLKSVGIPVLCLNSVDDVFSPSHAIPIETAK 360
           IREFDKRFTSVMFGYQTIDDYYTDASPSPRLKSVGIPVLCLNSVDDVFSPSHAIPIETAK
Sbjct: 301 IREFDKRFTSVMFGYQTIDDYYTDASPSPRLKSVGIPVLCLNSVDDVFSPSHAIPIETAK 360

Query: 361 QNPNVALVLTSYGGHIGFLEGIWPRQSTYMDRVFKQFVQAMVEHGHELS 409
           QNPNVALVLTSYGGHIGFLEGIWPRQSTYMDRVFKQFVQAMVEHGHELS
Sbjct: 361 QNPNVALVLTSYGGHIGFLEGIWPRQSTYMDRVFKQFVQAMVEHGHELS 409


>gi|194578891 abhydrolase domain-containing protein 1 [Homo sapiens]
          Length = 405

 Score =  359 bits (922), Expect = 2e-99
 Identities = 175/370 (47%), Positives = 259/370 (70%), Gaps = 2/370 (0%)

Query: 35  SLILGFSVA-YAFYYLSSIAKKPQLVTGGESFSRFLQDHCPVVTETYYPTVWCWEGRGQT 93
           SL+L  +VA Y  YY + + ++P+LV G + F  FL+ HC + TET+YPT+WC+EGR Q+
Sbjct: 18  SLLLALAVALYLGYYWACVLQRPRLVAGPQ-FLAFLEPHCSITTETFYPTLWCFEGRLQS 76

Query: 94  LLRPFITSKPPVQYRNELIKTADGGQISLDWFDNDNSTCYMDASTRPTILLLPGLTGTSK 153
           + +  + S+P V Y++++++T DGGQ+ LDW    +S+   D +T+P +LLLPG+TG+S+
Sbjct: 77  IFQVLLQSQPLVLYQSDILQTPDGGQLLLDWAKQPDSSQDPDPTTQPIVLLLPGITGSSQ 136

Query: 154 ESYILHMIHLSEELGYRCVVFNNRGVAGENLLTPRTYCCANTEDLETVIHHVHSLYPSAP 213
           E+Y+LH+++ +   GY+ VVFNNRG  GE L T R +C +NTEDLETV++H+   YP AP
Sbjct: 137 ETYVLHLVNQALRDGYQAVVFNNRGCRGEELRTHRAFCASNTEDLETVVNHIKHRYPQAP 196

Query: 214 FLAAGVSMGGMLLLNYLGKIGSKTPLMAAATFSVGWNTFACSESLEKPLNWLLFNYYLTT 273
            LA G+S GG+L+LN+L +      L+AA T S  W++F  + SLE PLN LLFN  LT 
Sbjct: 197 LLAVGISFGGILVLNHLAQARQAAGLVAALTLSACWDSFETTRSLETPLNSLLFNQPLTA 256

Query: 274 CLQSSVNKHRHMFVKQVDMDHVMKAKSIREFDKRFTSVMFGYQTIDDYYTDASPSPRLKS 333
            L   V ++R +  K VD+D V++A++IR+FD+R+TSV FGYQ    YY  ASP  ++ +
Sbjct: 257 GLCQLVERNRKVIEKVVDIDFVLQARTIRQFDERYTSVAFGYQDCVTYYKAASPRTKIDA 316

Query: 334 VGIPVLCLNSVDDVFSPSHAIPIETAKQNPNVALVLTSYGGHIGFLEGIWPRQSTYMDRV 393
           + IPVL L++ DD FSP  A+PI+ A+ +P VAL++T+ GGHIGFLEG+ P Q  YM R+
Sbjct: 317 IRIPVLYLSAADDPFSPVCALPIQAAQHSPYVALLITARGGHIGFLEGLLPWQHWYMSRL 376

Query: 394 FKQFVQAMVE 403
             Q+ +A+ +
Sbjct: 377 LHQYAKAIFQ 386


>gi|23397659 alpha/beta hydrolase domain containing protein 2 [Homo
           sapiens]
          Length = 425

 Score =  134 bits (338), Expect = 1e-31
 Identities = 93/379 (24%), Positives = 172/379 (45%), Gaps = 31/379 (8%)

Query: 49  LSSIAKKPQLVTGGESFSRFLQDHCPVVTETYYPT-VWCWEGRGQTLL---RPFITSKPP 104
           L S    P L       SRFL   CP++T+ Y P  +W   G  QT L      + S  P
Sbjct: 35  LKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHP 94

Query: 105 VQYRNELIKTADGGQISLDWFDNDNSTCYMDASTRPTILLLPGLTGTSKESYILHMIHLS 164
             +R + I  +DG   + D F+     C  D  T   +++ PG+   S++ YI   +  +
Sbjct: 95  YGHR-KFITMSDGATSTFDLFEPLAEHCVGDDIT---MVICPGIANHSEKQYIRTFVDYA 150

Query: 165 EELGYRCVVFNNRGVAGE-NLLTPRTYCCANTEDLETVIHHVHSLYPSAPFLAAGVSMGG 223
           ++ GYRC V N+ G      L +PR +    T +   +++++   YP    +  G S+GG
Sbjct: 151 QKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKKTYPLTQLVVVGFSLGG 210

Query: 224 MLLLNYLGKI-GSKTPLMAAATFSVGWNTFACSESLEKPLNW----LLFNYYLTTCLQSS 278
            ++  YLG+   ++  ++   +   G++     E+    + W      +N+ +   ++  
Sbjct: 211 NIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETF---MQWDQCRRFYNFLMADNMKKI 267

Query: 279 VNKHRHMF----------VKQVDMDHVMKAKSIREFDKRFTSVMFGYQTIDDYYTDASPS 328
           +  HR             ++  D+  +  A S+ + D        GY ++ +YY + S  
Sbjct: 268 ILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCM 327

Query: 329 PRLKSVGIPVLCLNSVDD--VFSPSHAIPIETAKQNPNVALVLTSYGGHIGFLEG--IWP 384
             L  + +P++ +N+ DD  V      IP   +++  NV  VL  +GGH+GF EG  ++P
Sbjct: 328 RYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFP 387

Query: 385 RQSTYMDRVFKQFVQAMVE 403
              T+MD++  ++  A+ +
Sbjct: 388 EPLTWMDKLVVEYANAICQ 406


>gi|23397661 alpha/beta hydrolase domain containing protein 2 [Homo
           sapiens]
          Length = 425

 Score =  134 bits (338), Expect = 1e-31
 Identities = 93/379 (24%), Positives = 172/379 (45%), Gaps = 31/379 (8%)

Query: 49  LSSIAKKPQLVTGGESFSRFLQDHCPVVTETYYPT-VWCWEGRGQTLL---RPFITSKPP 104
           L S    P L       SRFL   CP++T+ Y P  +W   G  QT L      + S  P
Sbjct: 35  LKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHP 94

Query: 105 VQYRNELIKTADGGQISLDWFDNDNSTCYMDASTRPTILLLPGLTGTSKESYILHMIHLS 164
             +R + I  +DG   + D F+     C  D  T   +++ PG+   S++ YI   +  +
Sbjct: 95  YGHR-KFITMSDGATSTFDLFEPLAEHCVGDDIT---MVICPGIANHSEKQYIRTFVDYA 150

Query: 165 EELGYRCVVFNNRGVAGE-NLLTPRTYCCANTEDLETVIHHVHSLYPSAPFLAAGVSMGG 223
           ++ GYRC V N+ G      L +PR +    T +   +++++   YP    +  G S+GG
Sbjct: 151 QKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKKTYPLTQLVVVGFSLGG 210

Query: 224 MLLLNYLGKI-GSKTPLMAAATFSVGWNTFACSESLEKPLNW----LLFNYYLTTCLQSS 278
            ++  YLG+   ++  ++   +   G++     E+    + W      +N+ +   ++  
Sbjct: 211 NIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETF---MQWDQCRRFYNFLMADNMKKI 267

Query: 279 VNKHRHMF----------VKQVDMDHVMKAKSIREFDKRFTSVMFGYQTIDDYYTDASPS 328
           +  HR             ++  D+  +  A S+ + D        GY ++ +YY + S  
Sbjct: 268 ILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCM 327

Query: 329 PRLKSVGIPVLCLNSVDD--VFSPSHAIPIETAKQNPNVALVLTSYGGHIGFLEG--IWP 384
             L  + +P++ +N+ DD  V      IP   +++  NV  VL  +GGH+GF EG  ++P
Sbjct: 328 RYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFP 387

Query: 385 RQSTYMDRVFKQFVQAMVE 403
              T+MD++  ++  A+ +
Sbjct: 388 EPLTWMDKLVVEYANAICQ 406


>gi|39930569 abhydrolase domain containing 15 [Homo sapiens]
          Length = 468

 Score =  111 bits (278), Expect = 1e-24
 Identities = 86/304 (28%), Positives = 136/304 (44%), Gaps = 11/304 (3%)

Query: 82  PTVWCWEGRGQTLLRPFITSKPPVQYRNELIKTADGGQISLDWFDND--NSTCYMDASTR 139
           P  W      QTL    +   P  +   E ++ AD G ++LDW             A   
Sbjct: 97  PRSWFSGPHLQTLCHFVLPVAPGPELAREYLQLADDGLVALDWVVGPCVRGRRITSAGGL 156

Query: 140 PTILL-LPGLTGTSKESYILHMIHLSEELGYRCVVFNNRGVAGENLLTPRTYCCANTEDL 198
           P +LL +P   G    + +L +  L+ E GY  V+F+ RG  G  L++PR     +  DL
Sbjct: 157 PAVLLVIPNAWGRLTRN-VLGLCLLALERGYYPVIFHRRGHHGCPLVSPRLQPFGDPSDL 215

Query: 199 ETVIHHVHSLYPSAPFLAAGVSMGGMLLLNYLGKIGSKTPLMAAATFSVGWNTFACSESL 258
           +  + ++   +P+AP  A     G  LLL+YLG+ GS + +  AA  S       C E  
Sbjct: 216 KEAVTYIRFRHPAAPLFAVSEGSGSALLLSYLGECGSSSYVTGAACIS---PVLRCREWF 272

Query: 259 EKPLNWLLFNYYLTTCLQSSVNKHRHMFVKQVDMDHVMKAKSIREFDKRFTSVMFGYQTI 318
           E  L W     +L    + +++++       VD   + +++S+REF++        +   
Sbjct: 273 EAGLPWPYERGFLLH-QKIALSRYATALEDTVDTSRLFRSRSLREFEEALFCHTKSFPIS 331

Query: 319 DDYYTDAS-PSPRLKSVGIPVLCLNSVDDVF--SPSHAIPIETAKQNPNVALVLTSYGGH 375
            D Y D + P   +    +PVLC+ S DD     P H +  E    NP   L+L+ +GGH
Sbjct: 332 WDAYWDRNDPLRDVDEAAVPVLCICSADDPVCGPPDHTLTTELFHSNPYFFLLLSRHGGH 391

Query: 376 IGFL 379
            GFL
Sbjct: 392 CGFL 395


>gi|109689718 abhydrolase domain containing 12 isoform a [Homo
           sapiens]
          Length = 398

 Score = 32.0 bits (71), Expect = 1.0
 Identities = 19/52 (36%), Positives = 28/52 (53%), Gaps = 1/52 (1%)

Query: 136 ASTRPTILLLPGLTGTSKESYILHMIHLSEELGYRCVVFNNRGVAGENLLTP 187
           AS+ P IL L G  GT    + + +  +   LGY  V F+ RG  G+++ TP
Sbjct: 165 ASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRG-WGDSVGTP 215


>gi|24308097 abhydrolase domain containing 12 isoform b [Homo
           sapiens]
          Length = 404

 Score = 32.0 bits (71), Expect = 1.0
 Identities = 19/52 (36%), Positives = 28/52 (53%), Gaps = 1/52 (1%)

Query: 136 ASTRPTILLLPGLTGTSKESYILHMIHLSEELGYRCVVFNNRGVAGENLLTP 187
           AS+ P IL L G  GT    + + +  +   LGY  V F+ RG  G+++ TP
Sbjct: 165 ASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRG-WGDSVGTP 215


>gi|190341095 transmembrane protein 63C [Homo sapiens]
          Length = 806

 Score = 30.8 bits (68), Expect = 2.3
 Identities = 23/91 (25%), Positives = 34/91 (37%), Gaps = 6/91 (6%)

Query: 122 LDWFDNDNSTCYMDASTRPTILLLPGLTGTSKESYILHMIHLSEELGYRCVVFNNRGVAG 181
           LDW  +   T  ++ ST   +L L  L          + I     + + C+ F  R    
Sbjct: 164 LDWSSHFARTTIVNVSTESKLLWLHSLLS------FFYFITNFMFMAHHCLGFAPRNSQK 217

Query: 182 ENLLTPRTYCCANTEDLETVIHHVHSLYPSA 212
                  TY   + ED E +I H H  YP +
Sbjct: 218 VTRTLMITYVPKDIEDPELIIKHFHEAYPGS 248


>gi|8923001 abhydrolase domain containing 10 [Homo sapiens]
          Length = 306

 Score = 30.4 bits (67), Expect = 3.0
 Identities = 20/89 (22%), Positives = 40/89 (44%), Gaps = 4/89 (4%)

Query: 140 PTILLLPGLTGTSKESYILHMIHLSEELGYRCVVFNNRGVAGENLLTPRTYCCANTEDLE 199
           P I+ +PG       +  L +    + LG+ C+ F+  GV   +  +  +      +D+ 
Sbjct: 76  PGIIFIPGYLSYMNGTKALAIEEFCKSLGHACIRFDYSGVGSSDGNSEESTLGKWRKDVL 135

Query: 200 TVIHHVHSLYPSAPFLAAGVSMGGMLLLN 228
           ++I  +       P +  G S+GG L+L+
Sbjct: 136 SIIDDL----ADGPQILVGSSLGGWLMLH 160


>gi|45439359 triple functional domain (PTPRF interacting) [Homo
           sapiens]
          Length = 3097

 Score = 29.6 bits (65), Expect = 5.2
 Identities = 19/54 (35%), Positives = 26/54 (48%), Gaps = 3/54 (5%)

Query: 196 EDLETVIHHVHSLYPSAPFLAAGVSMGGMLLLNYLGK---IGSKTPLMAAATFS 246
           +DLE  IHH   +Y       + VS  G  LL+ L +    GS   L A+A +S
Sbjct: 478 QDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYS 531


>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
          Length = 2986

 Score = 29.3 bits (64), Expect = 6.7
 Identities = 19/54 (35%), Positives = 25/54 (46%), Gaps = 3/54 (5%)

Query: 196 EDLETVIHHVHSLYPSAPFLAAGVSMGGMLLLNYLGK---IGSKTPLMAAATFS 246
           +DLE  IHH  +LY         VS  G  LL+ L +    G+   L A A +S
Sbjct: 448 QDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYS 501


>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
          Length = 1663

 Score = 29.3 bits (64), Expect = 6.7
 Identities = 19/54 (35%), Positives = 25/54 (46%), Gaps = 3/54 (5%)

Query: 196 EDLETVIHHVHSLYPSAPFLAAGVSMGGMLLLNYLGK---IGSKTPLMAAATFS 246
           +DLE  IHH  +LY         VS  G  LL+ L +    G+   L A A +S
Sbjct: 448 QDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYS 501


>gi|8922549 anti-silencing function 1B [Homo sapiens]
          Length = 202

 Score = 29.3 bits (64), Expect = 6.7
 Identities = 18/51 (35%), Positives = 23/51 (45%), Gaps = 10/51 (19%)

Query: 251 TFACSESLEKPLNWLL----------FNYYLTTCLQSSVNKHRHMFVKQVD 291
           +F CSE+L   L W +          F+  L + L   V   RHMFV Q D
Sbjct: 27  SFECSEALADDLEWKIIYVGSAESEEFDQILDSVLVGPVPAGRHMFVFQAD 77


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,488,220
Number of Sequences: 37866
Number of extensions: 687016
Number of successful extensions: 1278
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 1258
Number of HSP's gapped (non-prelim): 13
length of query: 409
length of database: 18,247,518
effective HSP length: 105
effective length of query: 304
effective length of database: 14,271,588
effective search space: 4338562752
effective search space used: 4338562752
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.