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Search of human proteins with 226817313
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform
1 [Homo sapiens]
(1849 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1... 3709 0.0
gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sap... 1342 0.0
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap... 1258 0.0
gi|169203021 PREDICTED: similar to Shank2E [Homo sapiens] 759 0.0
gi|19743796 SH3 and multiple ankyrin repeat domains 2 isoform 2 ... 464 e-130
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 99 5e-20
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 99 5e-20
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 99 5e-20
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 99 5e-20
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 99 5e-20
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 96 2e-19
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 96 3e-19
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 96 3e-19
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 96 3e-19
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 94 1e-18
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 87 2e-16
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 86 3e-16
gi|38327522 cardiac ankyrin repeat protein [Homo sapiens] 85 6e-16
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 85 7e-16
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 84 1e-15
gi|148833508 notch1 preproprotein [Homo sapiens] 84 1e-15
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 84 2e-15
gi|134244285 Notch homolog 3 [Homo sapiens] 83 3e-15
gi|55770876 notch4 preproprotein [Homo sapiens] 82 4e-15
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 81 1e-14
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 81 1e-14
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 80 2e-14
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 79 3e-14
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 79 5e-14
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 77 2e-13
>gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1
[Homo sapiens]
Length = 1849
Score = 3709 bits (9618), Expect = 0.0
Identities = 1849/1849 (100%), Positives = 1849/1849 (100%)
Query: 1 MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIR 60
MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIR
Sbjct: 1 MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIR 60
Query: 61 VVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKFLDEER 120
VVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKFLDEER
Sbjct: 61 VVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKFLDEER 120
Query: 121 LLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKIT 180
LLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKIT
Sbjct: 121 LLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKIT 180
Query: 181 KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAAR 240
KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAAR
Sbjct: 181 KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAAR 240
Query: 241 ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWH 300
ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWH
Sbjct: 241 ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWH 300
Query: 301 EIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELK 360
EIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELK
Sbjct: 301 EIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELK 360
Query: 361 NYNSQTPFQVAIIAGNFELAEYIKNHKETDIVPFREAPAYSNRRRRPPNTLAAPRVLLRS 420
NYNSQTPFQVAIIAGNFELAEYIKNHKETDIVPFREAPAYSNRRRRPPNTLAAPRVLLRS
Sbjct: 361 NYNSQTPFQVAIIAGNFELAEYIKNHKETDIVPFREAPAYSNRRRRPPNTLAAPRVLLRS 420
Query: 421 NSDNNLNASAPDWAVCSTATSHRSLSPQLLQQMPSKPEGAAKTIGSYVPGPRSRSPSLNR 480
NSDNNLNASAPDWAVCSTATSHRSLSPQLLQQMPSKPEGAAKTIGSYVPGPRSRSPSLNR
Sbjct: 421 NSDNNLNASAPDWAVCSTATSHRSLSPQLLQQMPSKPEGAAKTIGSYVPGPRSRSPSLNR 480
Query: 481 LGGAGEDGKRPQPLWHVGSPFALGANKDSLSAFEYPGPKRKLYSAVPGRLFVAVKPYQPQ 540
LGGAGEDGKRPQPLWHVGSPFALGANKDSLSAFEYPGPKRKLYSAVPGRLFVAVKPYQPQ
Sbjct: 481 LGGAGEDGKRPQPLWHVGSPFALGANKDSLSAFEYPGPKRKLYSAVPGRLFVAVKPYQPQ 540
Query: 541 VDGEIPLHRGDRVKVLSIGEGGFWEGSARGHIGWFPAECVEEVQCKPRDSQAETRADRSK 600
VDGEIPLHRGDRVKVLSIGEGGFWEGSARGHIGWFPAECVEEVQCKPRDSQAETRADRSK
Sbjct: 541 VDGEIPLHRGDRVKVLSIGEGGFWEGSARGHIGWFPAECVEEVQCKPRDSQAETRADRSK 600
Query: 601 KLFRHYTVGSYDSFDTSSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFP 660
KLFRHYTVGSYDSFDTSSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFP
Sbjct: 601 KLFRHYTVGSYDSFDTSSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFP 660
Query: 661 ALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVT 720
ALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVT
Sbjct: 661 ALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVT 720
Query: 721 RNLDPDDTARKKAPPPPKRAPTTALTLRSKSMTSELEELVDKASVRKKKDKPEEIVPASK 780
RNLDPDDTARKKAPPPPKRAPTTALTLRSKSMTSELEELVDKASVRKKKDKPEEIVPASK
Sbjct: 721 RNLDPDDTARKKAPPPPKRAPTTALTLRSKSMTSELEELVDKASVRKKKDKPEEIVPASK 780
Query: 781 PSRAAENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIP 840
PSRAAENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIP
Sbjct: 781 PSRAAENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIP 840
Query: 841 RGTMRRQKSIDSRIFLSGITEEERQFLAPPMLKFTRSLSMPDTSEDIPPPPQSVPPSPPP 900
RGTMRRQKSIDSRIFLSGITEEERQFLAPPMLKFTRSLSMPDTSEDIPPPPQSVPPSPPP
Sbjct: 841 RGTMRRQKSIDSRIFLSGITEEERQFLAPPMLKFTRSLSMPDTSEDIPPPPQSVPPSPPP 900
Query: 901 PSPTTYNCPKSPTPRVYGTIKPAFNQNSAAKVSPATRSDTVATMMREKGMYFRRELDRYS 960
PSPTTYNCPKSPTPRVYGTIKPAFNQNSAAKVSPATRSDTVATMMREKGMYFRRELDRYS
Sbjct: 901 PSPTTYNCPKSPTPRVYGTIKPAFNQNSAAKVSPATRSDTVATMMREKGMYFRRELDRYS 960
Query: 961 LDSEDLYSRNAGPQANFRNKRGQMPENPYSEVGKIASKAVYVPAKPARRKGMLVKQSNVE 1020
LDSEDLYSRNAGPQANFRNKRGQMPENPYSEVGKIASKAVYVPAKPARRKGMLVKQSNVE
Sbjct: 961 LDSEDLYSRNAGPQANFRNKRGQMPENPYSEVGKIASKAVYVPAKPARRKGMLVKQSNVE 1020
Query: 1021 DSPEKTCSIPIPTIIVKEPSTSSSGKSSQGSSMEIDPQAPEPPSQLRPDESLTVSSPFAA 1080
DSPEKTCSIPIPTIIVKEPSTSSSGKSSQGSSMEIDPQAPEPPSQLRPDESLTVSSPFAA
Sbjct: 1021 DSPEKTCSIPIPTIIVKEPSTSSSGKSSQGSSMEIDPQAPEPPSQLRPDESLTVSSPFAA 1080
Query: 1081 AIAGAVRDREKRLEARRNSPAFLSTDLGDEDVGLGPPAPRTRPSMFPEEGDFADEDSAEQ 1140
AIAGAVRDREKRLEARRNSPAFLSTDLGDEDVGLGPPAPRTRPSMFPEEGDFADEDSAEQ
Sbjct: 1081 AIAGAVRDREKRLEARRNSPAFLSTDLGDEDVGLGPPAPRTRPSMFPEEGDFADEDSAEQ 1140
Query: 1141 LSSPMPSATPREPENHFVGGAEASAPGEAGRPLNSTSKAQGPESSPAVPSASSGTAGPGN 1200
LSSPMPSATPREPENHFVGGAEASAPGEAGRPLNSTSKAQGPESSPAVPSASSGTAGPGN
Sbjct: 1141 LSSPMPSATPREPENHFVGGAEASAPGEAGRPLNSTSKAQGPESSPAVPSASSGTAGPGN 1200
Query: 1201 YVHPLTGRLLDPSSPLALALSARDRAMKESQQGPKGEAPKADLNKPLYIDTKMRPSLDAG 1260
YVHPLTGRLLDPSSPLALALSARDRAMKESQQGPKGEAPKADLNKPLYIDTKMRPSLDAG
Sbjct: 1201 YVHPLTGRLLDPSSPLALALSARDRAMKESQQGPKGEAPKADLNKPLYIDTKMRPSLDAG 1260
Query: 1261 FPTVTRQNTRGPLRRQETENKYETDLGRDRKGDDKKNMLIDIMDTSQQKSAGLLMVHTVD 1320
FPTVTRQNTRGPLRRQETENKYETDLGRDRKGDDKKNMLIDIMDTSQQKSAGLLMVHTVD
Sbjct: 1261 FPTVTRQNTRGPLRRQETENKYETDLGRDRKGDDKKNMLIDIMDTSQQKSAGLLMVHTVD 1320
Query: 1321 ATKLDNALQEEDEKAEVEMKPDSSPSEVPEGVSETEGALQISAAPEPTTVPGRTIVAVGS 1380
ATKLDNALQEEDEKAEVEMKPDSSPSEVPEGVSETEGALQISAAPEPTTVPGRTIVAVGS
Sbjct: 1321 ATKLDNALQEEDEKAEVEMKPDSSPSEVPEGVSETEGALQISAAPEPTTVPGRTIVAVGS 1380
Query: 1381 MEEAVILPFRIPPPPLASVDLDEDFIFTEPLPPPLEFANSFDIPDDRAASVPALSDLVKQ 1440
MEEAVILPFRIPPPPLASVDLDEDFIFTEPLPPPLEFANSFDIPDDRAASVPALSDLVKQ
Sbjct: 1381 MEEAVILPFRIPPPPLASVDLDEDFIFTEPLPPPLEFANSFDIPDDRAASVPALSDLVKQ 1440
Query: 1441 KKSDTPQSPSLNSSQPTNSADSKKPASLSNCLPASFLPPPESFDAVADSGIEEVDSRSSS 1500
KKSDTPQSPSLNSSQPTNSADSKKPASLSNCLPASFLPPPESFDAVADSGIEEVDSRSSS
Sbjct: 1441 KKSDTPQSPSLNSSQPTNSADSKKPASLSNCLPASFLPPPESFDAVADSGIEEVDSRSSS 1500
Query: 1501 DHHLETTSTISTVSSISTLSSEGGENVDTCTVYADGQAFMVDKPPVPPKPKMKPIIHKSN 1560
DHHLETTSTISTVSSISTLSSEGGENVDTCTVYADGQAFMVDKPPVPPKPKMKPIIHKSN
Sbjct: 1501 DHHLETTSTISTVSSISTLSSEGGENVDTCTVYADGQAFMVDKPPVPPKPKMKPIIHKSN 1560
Query: 1561 ALYQDALVEEDVDSFVIPPPAPPPPPGSAQPGMAKVLQPRTSKLWGDVTEIKSPILSGPK 1620
ALYQDALVEEDVDSFVIPPPAPPPPPGSAQPGMAKVLQPRTSKLWGDVTEIKSPILSGPK
Sbjct: 1561 ALYQDALVEEDVDSFVIPPPAPPPPPGSAQPGMAKVLQPRTSKLWGDVTEIKSPILSGPK 1620
Query: 1621 ANVISELNSILQQMNREKLAKPGEGLDSPMGAKSASLAPRSPEIMSTISGTRSTTVTFTV 1680
ANVISELNSILQQMNREKLAKPGEGLDSPMGAKSASLAPRSPEIMSTISGTRSTTVTFTV
Sbjct: 1621 ANVISELNSILQQMNREKLAKPGEGLDSPMGAKSASLAPRSPEIMSTISGTRSTTVTFTV 1680
Query: 1681 RPGTSQPITLQSRPPDYESRTSGTRRAPSPVVSPTEMNKETLPAPLSAATASPSPALSDV 1740
RPGTSQPITLQSRPPDYESRTSGTRRAPSPVVSPTEMNKETLPAPLSAATASPSPALSDV
Sbjct: 1681 RPGTSQPITLQSRPPDYESRTSGTRRAPSPVVSPTEMNKETLPAPLSAATASPSPALSDV 1740
Query: 1741 FSLPSQPPSGDLFGLNPAGRSRSPSPSILQQPISNKPFTTKPVHLWTKPDVADWLESLNL 1800
FSLPSQPPSGDLFGLNPAGRSRSPSPSILQQPISNKPFTTKPVHLWTKPDVADWLESLNL
Sbjct: 1741 FSLPSQPPSGDLFGLNPAGRSRSPSPSILQQPISNKPFTTKPVHLWTKPDVADWLESLNL 1800
Query: 1801 GEHKEAFMDNEIDGSHLPNLQKEDLIDLGVTRVGHRMNIERALKQLLDR 1849
GEHKEAFMDNEIDGSHLPNLQKEDLIDLGVTRVGHRMNIERALKQLLDR
Sbjct: 1801 GEHKEAFMDNEIDGSHLPNLQKEDLIDLGVTRVGHRMNIERALKQLLDR 1849
>gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sapiens]
Length = 1747
Score = 1342 bits (3472), Expect = 0.0
Identities = 849/1877 (45%), Positives = 1091/1877 (58%), Gaps = 224/1877 (11%)
Query: 55 NTLVIRVVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGK 114
+ +V+RV I DLQQTKC+R +P A VW AKQR+LC L SL+D LNYGLFQP S GR GK
Sbjct: 7 SAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGK 66
Query: 115 FLDEERLLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHR 174
FLDEERLL+EYP + +P LEFRYK+RVY Q +D+KQ AKLHTK NLKK MD++Q
Sbjct: 67 FLDEERLLQEYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLH 126
Query: 175 LVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTA 234
+K+ ++LD+GLDPNFHDP++GE PL+LAAQLD++ +++K LKNGGAHLDFR +DG+TA
Sbjct: 127 STDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTA 186
Query: 235 LHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCK 294
+H A R RN AL TLL+LGASPDYKDS GLTPLYH+A+ GGD CCELLLH+HA +
Sbjct: 187 VHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGIT 246
Query: 295 DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRG 354
DENGW EIHQACR+GHVQHLEHLLFYGADM AQNASGNTALHICALYNQ+SCARVLLFRG
Sbjct: 247 DENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRG 306
Query: 355 GNKELKNYNSQTPFQVAIIAGNFELAEYIKNHKETDIVPFREAPAYSNRRR-RPPNTLAA 413
N++++NYNSQT FQVAIIAGNFELAE IK HK++D+VPFRE P+Y+ RRR P+ LA+
Sbjct: 307 ANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRRLAGPSGLAS 366
Query: 414 PRVLLRSNSDNNLNASAPDWAVCSTATSHRSLSPQLLQQ--MPSKPEGAAKTIGSYVPGP 471
PR L RS SD NL A A S S RSL QLL Q K S + GP
Sbjct: 367 PRPLQRSASDINLKGEAQPAA--SPGPSLRSLPHQLLLQRLQEEKDRDRDADQESNISGP 424
Query: 472 RSRSPSLNRLG--GAGEDGKRPQPLWHVGSPFALGANKDSLSAFEYP------GPKRKLY 523
+ +++ G G G PL G+P + + A P GPKRKLY
Sbjct: 425 LAGRAGQSKISDPGPGPGGVGGAPLPPPGAPRSCIRIRARFPAPPAPPAPPPRGPKRKLY 484
Query: 524 SAVPGRLFVAVKPYQPQVDGEIPLHRGDRVKVLSIGEGGFWEGSARGHIGWFPAECVEEV 583
SAVPGR F+AVK + PQ +GEIPLHRG+ VKVLSIGEGGFWEG+ +G GWFPA+CVEEV
Sbjct: 485 SAVPGRKFIAVKAHSPQGEGEIPLHRGEAVKVLSIGEGGFWEGTVKGRTGWFPADCVEEV 544
Query: 584 QCKPRDSQAETRADRSKKLFRHYTVGSYDSFDTSSDCIIEEKTVVLQKKDNEGFGFVLRG 643
Q + D++ ETR DR+K+LFRHYTVGSYDS + SD +I++K VLQK+D+EGFGFVLRG
Sbjct: 545 QMRQHDTRPETREDRTKRLFRHYTVGSYDSLTSHSDYVIDDKVAVLQKRDHEGFGFVLRG 604
Query: 644 AKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVN 703
AKA+TPIEEFTPTPAFPALQYLESVD GVAW+AGLRTGDFLIEVN NVVKVGH+QVV
Sbjct: 605 AKAETPIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVA 664
Query: 704 MIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPPKRAPTTALTLRSKSMTSELEELVDKA 763
+IRQGGN LV+KVV+VTR + +D AR++APPPPKRAP+T LTLRSKSMT+ELEEL A
Sbjct: 665 LIRQGGNRLVMKVVSVTRKPE-EDGARRRAPPPPKRAPSTTLTLRSKSMTAELEEL---A 720
Query: 764 SVRKKKDK--PEEIVPASKPSRAAENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGI 821
S+R++K + E + A++P+ + + R AT+KQRP+SR ++++S++ERQG+
Sbjct: 721 SIRRRKGEKLDEMLAAAAEPTLRPDIADADSRAATVKQRPTSRRI-TPAEISSLFERQGL 779
Query: 822 AVMTPTVPGSPKAPFLGIPRGTMRRQKSIDSRIFLSGITEEERQFLAPPMLKFTRSLSMP 881
PG K P G R + R KS+ L+ + E +F RS SM
Sbjct: 780 -------PGPEKLP--GSLRKGIPRTKSVGEDEKLASLLEG----------RFPRSTSMQ 820
Query: 882 DTSED---IPPPPQSVPPSPPPP-----SPTTYNCPKSPTPRVYGTIKPAFNQNSAAKV- 932
D + IPPPPQ+ PP PP P P P P R Y T++ +F A++
Sbjct: 821 DPVREGRGIPPPPQTAPPPPPAPYYFDSGPPPAFSPPPPPGRAYDTVRSSFKPGLEARLG 880
Query: 933 -------SPATRSDTVATMMREK---GMYFRRELDRYSLDSEDLYSRNAGPQANFRNKRG 982
P + R+K M ++ S D+ P+ R R
Sbjct: 881 AGAAGLYEPGAALGPLPYPERQKRARSMIILQDSAPESGDAPRPPPAATPPERPKRRPRP 940
Query: 983 QMPENPYSEVGKIASKAVYVPAKPARRKGMLVKQSNVEDSPEKTCSI-----PIPTIIVK 1037
P++PY+ +G S +++ P+KP RRK LVKQ VED+ E+ P +
Sbjct: 941 PGPDSPYANLGAF-SASLFAPSKPQRRKSPLVKQLQVEDAQERAALAVGSPGPGGGSFAR 999
Query: 1038 EPSTSSSGKSSQGSSMEIDPQAPEPPSQLRPDESLTVSSPFAAAIAGAVRDREKRLEARR 1097
EPS + G G +D A + P A G +++RLE RR
Sbjct: 1000 EPSPTHRGPRPGG----LDYGAGDGP---------------GLAFGGPGPAKDRRLEERR 1040
Query: 1098 NSPAFLSTDLGDEDVGLGPPAPRTRPSMFPEEGDFADEDSAEQLSSPMPSATP-REPENH 1156
S FLS A E SA + +PS P R +
Sbjct: 1041 RSTVFLSVG--------------------------AIEGSAP--GADLPSLQPSRSIDER 1072
Query: 1157 FVGGAEASAPGEAGRPLNSTSKAQGPESSPAVPSASSGTAGPGNYVHPLTGRLLDPSSPL 1216
+G AGR L S P V S G +G ++HPLTG+ LDPSSPL
Sbjct: 1073 LLGTGPT-----AGRDLLLPSPVSA--LKPLVSGPSLGPSG-STFIHPLTGKPLDPSSPL 1124
Query: 1217 ALALSARDRAMKE---SQQGPKGEAPKADLNKPLYIDTKMRPSLDAGFPTVTRQNTRGPL 1273
ALAL+AR+RA+ S+ +P AD PL++D + R + G + R P
Sbjct: 1125 ALALAARERALASQAPSRSPTPVHSPDADRPGPLFVDVQARDP-ERGSLASPAFSPRSPA 1183
Query: 1274 -----RRQETENKYETDLGRDRKGDDKKNMLIDIMDTSQQKSAGLLMVHTVDATKLDNAL 1328
R+E E + + +DKK+M++ ++DTS Q+ AGL++VH + + L
Sbjct: 1184 WIPVPARREAE---KVPREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSRL 1240
Query: 1329 --QEEDEKAEVEMKPDSSPSEVPEGVSETEGALQISAAPEPTTVPGRTIVAVGSMEEAVI 1386
EE+ E+ P P + L A P P GS EE
Sbjct: 1241 GGAEEERPGTPELAP------APMQSAAVAEPLPSPRAQPPGGTPADAGPGQGSSEEEPE 1294
Query: 1387 LPF--RIPPPPLASVDLD--EDFIFTEPLPPPLEFANSFDIPDDRAASVPALSDLVKQKK 1442
L F +PP L+S D + E+ +PPP EFAN + A P+
Sbjct: 1295 LVFAVNLPPAQLSSSDEETREELARIGLVPPPEEFANGVLLATPLAGPGPS--------- 1345
Query: 1443 SDTPQSPSLNSSQPTNSADSKKPASLSNCLPASFLPPPESFDAVADSGIEEVDSRSSSDH 1502
T SP+ S KP+S PP + ++ ADSG+EE D+RSSSD
Sbjct: 1346 PTTVPSPA-----------SGKPSS----------EPPPAPESAADSGVEEADTRSSSDP 1384
Query: 1503 HLETTSTISTVSSISTLSSEGGENVDTCTVYADGQAFMVDKPPVPPKPKMKPIIHKSNAL 1562
HLETTSTISTVSS+STLSSE GE DT T +ADG F+++KPPVPPKPK+K + K
Sbjct: 1385 HLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKLKSPLGKGPVT 1444
Query: 1563 YQDALVEEDVDSFVIPPPAPPPPPG---SAQPGMAKVLQPRTSKLWGDVTEIKSPILSGP 1619
++D L+++ DS ++ G +A P + L R SKLWGD E + L GP
Sbjct: 1445 FRDPLLKQSSDSELMAQQHHAASAGLASAAGPARPRYLFQRRSKLWGDPVESRG--LPGP 1502
Query: 1620 ---KANVISELNSILQQMNREKLA---KPGEGLDSPMG-AKSASLAP----RSPEIMSTI 1668
K VISEL+S LQQ+N++ + +P GL S + AK + +A S +S+I
Sbjct: 1503 EDDKPTVISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAAARLFSSLGELSSI 1562
Query: 1669 SGTRST-----TVTFTVRPGTSQPITLQSRPPDYESRTSGTRRAPSPVVSPTEMNKETLP 1723
S RS +++VRP P+ RRAPSPV + E L
Sbjct: 1563 SAQRSPGGPGGGASYSVRPSGRYPV---------------ARRAPSPVKPASLERVEGLG 1607
Query: 1724 APLSAA-----TASPSPALSDVFSLPSQPPSGDLFGLNPAGRSRSPSPSILQQPIS---- 1774
A A P+ S S+P +P + + RSRSPSPS L P S
Sbjct: 1608 AGAGGAGRPFGLTPPTILKSSSLSIPHEPKEVRFVVRSVSARSRSPSPSPLPSPASGPGP 1667
Query: 1775 -----NKPFTTKPVHLWTKPDVADWLESLNLGEHKEAFMDNEIDGSHLPNLQKEDLIDLG 1829
+PF KP+ LW+K DV DWLES++LGEH++ F D+EI+G+HLP L K+D ++LG
Sbjct: 1668 GAPGPRRPFQQKPLQLWSKFDVGDWLESIHLGEHRDRFEDHEIEGAHLPALTKDDFVELG 1727
Query: 1830 VTRVGHRMNIERALKQL 1846
VTRVGHRMNIERAL+QL
Sbjct: 1728 VTRVGHRMNIERALRQL 1744
>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sapiens]
Length = 2161
Score = 1258 bits (3255), Expect = 0.0
Identities = 890/2227 (39%), Positives = 1125/2227 (50%), Gaps = 444/2227 (19%)
Query: 1 MPRSPTSSEDEMAQSFSDYSVG-SESDSSKEETIYDTIRATAEKPGGAR----------- 48
M SP +SEDE S S+ G SESDSS + R T + GA
Sbjct: 1 MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGP-RGTRGQGSGAPGSLASVRGLQG 59
Query: 49 -----TEESQGNTLVIRVVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGL 103
+++ + +V R+ I DL QTKC+RFNPDAT+W AKQ++LC L++SL+DVLNYGL
Sbjct: 60 RSMSVPDDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGL 119
Query: 104 FQPASNGRDGKFLDEERLLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTN 163
FQPA++GRD FL+EERLLREYPQ +GVP LEFRYK RVYKQ +LDEKQLAKLHTKT
Sbjct: 120 FQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTG 179
Query: 164 LKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAH 223
LKK ++++Q +K+ ++LD+GLDPN+HD ++GETPLTLAAQ + SVEVI+ L GGAH
Sbjct: 180 LKKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAH 239
Query: 224 LDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCEL 283
+DFRA+DGMTALHKAA AR+ +AL LL+LG SP+YKD GLTPL+HTA+VGGDP CCEL
Sbjct: 240 IDFRARDGMTALHKAACARHCLALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCEL 299
Query: 284 LLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQ 343
LL A + DENGW EIHQAC+ GH QHLEHLLFYGA+ AQNASGNTALHICALYN+
Sbjct: 300 LLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNK 359
Query: 344 DSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHKETDIVPFREAPAYSNR 403
++CAR+LL+RG +K++KN N QTPFQVA+IAGNFEL E I+NH+E D+VPF+E+P Y+ R
Sbjct: 360 ETCARILLYRGADKDVKNNNGQTPFQVAVIAGNFELGELIRNHREQDVVPFQESPKYAAR 419
Query: 404 RRRPPNT-LAAPRVLLRSNSDNNLNASAPDWAVCST--ATSHRSLSPQLLQQMPSKPEGA 460
RR PP T L P LLR+NSD ++ + PDW V S A S + P Q S+P
Sbjct: 420 RRGPPGTGLTVPPALLRANSDTSM--ALPDWMVFSAPGAASSGAPGPTSGSQGQSQPSAP 477
Query: 461 AKTIGSYV-------PGPRSRSPSLNRLGGAGEDGKRPQPLWHVGSPFALGANKDSLS-- 511
+ S G R+RSPS R ED KR QP G P + G ++ +
Sbjct: 478 TTKLSSGTLRSASSPRGARARSPSRGR---HPEDAKR-QPR---GRPSSSGTPREGPAGG 530
Query: 512 ---------AFEYPGPKRKLYSAVPGRLFVAVKPYQPQVDGEIPLHRGDRVKVLSIGEGG 562
+ G +RKLYSAVPGR F+AVK YQ Q +GEI L +G+++KVLSIGEGG
Sbjct: 531 TGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQAEGEISLSKGEKIKVLSIGEGG 590
Query: 563 FWEGSARGHIGWFPAECVEEVQCKPRDSQAETRADRSKKLFRHYTVGSYDSFDT------ 616
FWEG +G +GWFP++C+EEV + ++S+ E+R+D++K+LFRHYTVGSYDSFD
Sbjct: 591 FWEGQVKGRVGWFPSDCLEEVANRSQESKQESRSDKAKRLFRHYTVGSYDSFDAPSLMDG 650
Query: 617 ---SSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGV 673
SD II+EKTV+LQKKD+EGFGFVLRGAKA TPIEEFTPTPAFPALQYLESVDEGGV
Sbjct: 651 IGPGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGV 710
Query: 674 AWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKA 733
AW+AGLR GDFLIEVN +NVVKVGHRQVVNMIRQGGN L++KVV VTR+ D D+ KKA
Sbjct: 711 AWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKA 770
Query: 734 PPPPKRAPTTALTLRSKSMTSELEEL------VDKASVRKKK-------DKPEEIVPASK 780
P KR P ++LRSKSMTSELEE+ S+ KK+ +K +EI+ A++
Sbjct: 771 PQQAKRLPPPTISLRSKSMTSELEEMEYEQQPAPVPSMEKKRTVYQMALNKLDEILAAAQ 830
Query: 781 PSRAAENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIP 840
+ +A +A++ + F S + + Q P + FL
Sbjct: 831 QTISASESPGPGGLASLGKHRPKGFFATESSFDPHHRAQ---------PSYERPSFLPPG 881
Query: 841 RGTMRRQKSIDSRIFLSGITEEERQFLAPPMLKFTRSLSMPDTSEDIPPPPQSVPPSPPP 900
G M RQKSI G E++R +LAPP +KF+RSLS+P SEDIPPPP + PP PP
Sbjct: 882 PGLMLRQKSI-------GAAEDDRPYLAPPAMKFSRSLSVPG-SEDIPPPPTTSPPEPPY 933
Query: 901 PSPTTYNCPKSPTPRVYGTIKPA-----FNQNSAAKV---SPAT----RSDTVATMMREK 948
+P P P G + P+ FN S + SPA+ REK
Sbjct: 934 STP--------PVPSSSGRLTPSPRGGPFNPGSGGPLPASSPASFDGPSPPDTRVGSREK 985
Query: 949 GMYFRRELDRYSLDSEDLYSRNA---------------------------------GPQA 975
+Y L + +A GPQ
Sbjct: 986 SLYHSGPLPPAHHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALGPQP 1045
Query: 976 NFRNKRG-------------------------QMPENPYSEV-GKIASKAVYVPAKPAR- 1008
+ R RG Q P Y ++ + AS A+YVPA+ R
Sbjct: 1046 SLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQGPALRYFQLPPRAASAAMYVPARSGRG 1105
Query: 1009 RKGMLVKQSNVEDSPEK---------------------------TCSIPIPTIIVKEPST 1041
RKG LVKQ+ VE P+K SIPIPTII+K PST
Sbjct: 1106 RKGPLVKQTKVEGEPQKGGGLPPAPSPTSPASPQPPPAVAAPSEKNSIPIPTIIIKAPST 1165
Query: 1042 SSSGKSSQGSSMEIDPQA-PEP-----------------------------PSQLRPDES 1071
SSSG+SSQGSS E +P PEP P+ +
Sbjct: 1166 SSSGRSSQGSSTEAEPPTQPEPTGGGGGGGSSPSPAPAMSPVPPSPSPVPTPASPSGPAT 1225
Query: 1072 LTVSSPFAAAIAGAV-RDREKRLEARRNSPAFLSTDLGDEDVGLG------PPAPRTRPS 1124
L +S F AA+ GA R+ + EARR S FLSTD GDED G G P PR R S
Sbjct: 1226 LDFTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDEDGGDGGLGTGAAPGPRLRHS 1285
Query: 1125 MFPEEGDFADEDSAEQLSSPMPSATPREPENHFVGGAEASAPGEAGRPLNSTSKAQGPES 1184
+EG F+ E S+ S G G S + G S
Sbjct: 1286 KSIDEGMFSAEPYLRLESA-------------------GSGAGYGGYGAGSRAYGGGGGS 1326
Query: 1185 SPAVPSASSGTAGPGNYVHPLTGRLLDPSSPLALALSARDRAMKESQQGPKGEAPKADLN 1244
SA + P VHPLTG+ LDP+SPL LAL+AR+RA+KES +G P
Sbjct: 1327 -----SAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERALKESSEGGGAPQPPPRPP 1381
Query: 1245 KPLYIDTKMRP---SLDAGFPTVTRQNTRGPLRRQETENKYETDLGRDRKG------DDK 1295
P Y P S A V R P E Y LG K +
Sbjct: 1382 SPRYEAPPPTPHHHSPHAHHEPVLRLWGASPPDPARRELGYRAGLGSQEKSLPASPPAAR 1441
Query: 1296 KNMLIDIMDTSQQKSAGLLMV-------HTVDATKLDNALQEEDEKAEVEMK-----PDS 1343
+++L + T+ LL + H + +A EE E+ + ++
Sbjct: 1442 RSLLHRLPPTAPGVGPLLLQLGTEPPAPHPGVSKPWRSAAPEEPERLPLHVRFLENCQPR 1501
Query: 1344 SPSEVPEGVSETEGALQISAAPEPTTVPGRTIVAVGSMEEAVILPFRIPPPPLASVDL-D 1402
+P G +G +P + P T E LP + PPP SVD+ D
Sbjct: 1502 APVTSGRGPPSEDGPGVPPPSPRRSVPPSPTSPRA---SEENGLPLLVLPPPAPSVDVED 1558
Query: 1403 EDFIFTEPLPPPLEFANSFDIPDDR---------------------------AASVPALS 1435
+F+F EPLPPPLEF+NSF+ P+ AA+ P L
Sbjct: 1559 GEFLFVEPLPPPLEFSNSFEKPESPLTPGPPHPLPDTPAPATPLPPVPPPAVAAAPPTLD 1618
Query: 1436 DLVKQKKSDTPQSPSLNSSQPTNSADSKKPASLSNCLPASFLPPP-ESFDAVADSGIEEV 1494
S + +L D P + PA P P DSGIEEV
Sbjct: 1619 STASSLTSYDSEVATLTQGASAAPGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGIEEV 1678
Query: 1495 DSRSSSDHHLETTSTISTVSSISTLSSEGG-----------------ENVDTCTVYADGQ 1537
DSRSSSDH LE TIS+ S++S+LS+EGG E +DT Y DGQ
Sbjct: 1679 DSRSSSDHPLE---TISSASTLSSLSAEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQ 1735
Query: 1538 AFMVDKPPVPPKPK--MKPIIHKSNALYQDALVEEDVDSFVIPPPAPPPP---------- 1585
AF P PP P M P + AL + + P P P
Sbjct: 1736 AFGGSSTPGPPYPPQLMTPSKLRGRALGASGGLRPGPSGGLRDPVTPTSPTVSVTGAGTD 1795
Query: 1586 -------------------PGSAQPGMAKVLQPRTSKL------WGDVTEIKSPILSGP- 1619
P + +P + V P S L W + P L GP
Sbjct: 1796 GLLALRACSGPPTAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPL 1855
Query: 1620 -----------KANVISELNSILQQMNREKLA---------KPGEGLDSPMGAKS----- 1654
KA++ISEL+S LQQ A G G DS G S
Sbjct: 1856 AQPQASALATVKASIISELSSKLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPER 1915
Query: 1655 --------------ASLAPR----------SPEIMSTISGTRSTTVTFTVRPGTSQPITL 1690
+SL + P + +GT + T PG + P
Sbjct: 1916 TSSLQRQRLSDDSQSSLLSKPVSSLFQNWPKPPLPPLPTGT-GVSPTAAAAPGATSPSAS 1974
Query: 1691 QS-------RPPDYESRTSGTRRAPSPVVSPTEMNK-ETLPAPLSAATASPSPALSDVFS 1742
S + ++E R RRAPSP + P +K P P S P +F
Sbjct: 1975 SSSTSTRHLQGVEFEMRPPLLRRAPSPSLLPASEHKVSPAPRPSSLPILPSGPLYPGLFD 2034
Query: 1743 LPSQPPSGDLFGLNP--------------------AGRSRSPSPSILQQPISNKPFTTKP 1782
+ P G +P +G SRS SP+ L +KPF KP
Sbjct: 2035 IRGSPTGGAGGSADPFAPVFVPPHPGISGGLGGALSGASRSLSPTRLLSLPPDKPFGAKP 2094
Query: 1783 VHLWTKPDVADWLESLNLGEHKEAFMDNEIDGSHLPNLQKEDLIDLGVTRVGHRMNIERA 1842
+ WTK DVADWLE L L EH+ F+D+EIDGSHLP L KED +DLGVTRVGHRMNI+RA
Sbjct: 2095 LGFWTKFDVADWLEWLGLAEHRAQFLDHEIDGSHLPALTKEDYVDLGVTRVGHRMNIDRA 2154
Query: 1843 LKQLLDR 1849
LK L+R
Sbjct: 2155 LKFFLER 2161
>gi|169203021 PREDICTED: similar to Shank2E [Homo sapiens]
Length = 385
Score = 759 bits (1960), Expect = 0.0
Identities = 371/376 (98%), Positives = 373/376 (99%)
Query: 1 MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIR 60
MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIR
Sbjct: 1 MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIR 60
Query: 61 VVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKFLDEER 120
VVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKFLDEER
Sbjct: 61 VVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKFLDEER 120
Query: 121 LLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKIT 180
LLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKIT
Sbjct: 121 LLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKIT 180
Query: 181 KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAAR 240
KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAAR
Sbjct: 181 KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAAR 240
Query: 241 ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWH 300
ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWH
Sbjct: 241 ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWH 300
Query: 301 EIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELK 360
EIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELK
Sbjct: 301 EIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELK 360
Query: 361 NYNSQTPFQVAIIAGN 376
NYNSQTPFQV I+ +
Sbjct: 361 NYNSQTPFQVKEISAS 376
>gi|19743796 SH3 and multiple ankyrin repeat domains 2 isoform 2
[Homo sapiens]
Length = 281
Score = 464 bits (1194), Expect = e-130
Identities = 233/236 (98%), Positives = 234/236 (99%)
Query: 618 SDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQA 677
SDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQA
Sbjct: 30 SDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQA 89
Query: 678 GLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPP 737
GLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPP
Sbjct: 90 GLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPP 149
Query: 738 KRAPTTALTLRSKSMTSELEELVDKASVRKKKDKPEEIVPASKPSRAAENMAVEPRVATI 797
KRAPTTALTLRSKSMTSELEELVDKASVRKKKDKPEEIVPASKPSRAAENMAVEPRVATI
Sbjct: 150 KRAPTTALTLRSKSMTSELEELVDKASVRKKKDKPEEIVPASKPSRAAENMAVEPRVATI 209
Query: 798 KQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIPRGTMRRQKSIDSR 853
KQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIPRGTMRRQKSI +
Sbjct: 210 KQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIPRGTMRRQKSIGKK 265
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 98.6 bits (244), Expect = 5e-20
Identities = 69/202 (34%), Positives = 101/202 (50%), Gaps = 3/202 (1%)
Query: 179 ITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKA 238
+ +L RG PN + + ETPL +AA+ + EV K L A ++ +AKD T LH A
Sbjct: 453 VKNLLQRGASPNVSNVKV-ETPLHMAARAGHT-EVAKYLLQNKAKVNAKAKDDQTPLHCA 510
Query: 239 ARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENG 298
AR + +K LLE A+P+ + G TPL H A G LL + A+ C + G
Sbjct: 511 ARIGHTNMVKLLLENNANPNLATTAGHTPL-HIAAREGHVETVLALLEKEASQACMTKKG 569
Query: 299 WHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKE 358
+ +H A +YG V+ E LL A +A +G T LH+ +N ++LL RGG+
Sbjct: 570 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 629
Query: 359 LKNYNSQTPFQVAIIAGNFELA 380
+N TP +A E+A
Sbjct: 630 SPAWNGYTPLHIAAKQNQVEVA 651
Score = 94.0 bits (232), Expect = 1e-18
Identities = 80/284 (28%), Positives = 129/284 (45%), Gaps = 41/284 (14%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+RG NF P+ G TPL +A++ + + +++ L + GA ++ + KD +T LH AAR
Sbjct: 258 LLNRGASVNF-TPQNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARN 315
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHE-------------- 287
+ + LL+ GA K GL+P+ H A G C LLL
Sbjct: 316 GHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 374
Query: 288 -HATVCCKDE------------------NGWHEIHQACRYGHVQHLEHLLFYGADMSAQN 328
H C NG+ +H AC+ HV+ +E LL GA + A
Sbjct: 375 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 434
Query: 329 ASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHKE 388
SG T LH+ + + LL RG + + N +TP +A AG+ E+A+Y+ +K
Sbjct: 435 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 494
Query: 389 TDIVPFR--EAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNASA 430
+ + P + R N + ++LL +N++ NL +A
Sbjct: 495 KVNAKAKDDQTPLHCAARIGHTNMV---KLLLENNANPNLATTA 535
Score = 81.3 bits (199), Expect = 8e-15
Identities = 65/220 (29%), Positives = 97/220 (44%), Gaps = 5/220 (2%)
Query: 167 CMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDF 226
C I H + K+ +L+ +PN G TPL +AA+ + VE + AL A
Sbjct: 509 CAARIGHTNMVKL--LLENNANPNLATT-AGHTPLHIAAR-EGHVETVLALLEKEASQAC 564
Query: 227 RAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLH 286
K G T LH AA+ + LLE A P+ GLTPL H A+ + +LLL
Sbjct: 565 MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL-HVAVHHNNLDIVKLLLP 623
Query: 287 EHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSC 346
+ NG+ +H A + V+ LL YG +A++ G T LH+ A
Sbjct: 624 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 683
Query: 347 ARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
+LL + N L N + TP + G+ +A+ + H
Sbjct: 684 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723
Score = 77.8 bits (190), Expect = 9e-14
Identities = 68/246 (27%), Positives = 101/246 (41%), Gaps = 36/246 (14%)
Query: 170 HIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAK 229
H H V K+ +LD+G PN G TPL +A + + V V++ L GA +D +
Sbjct: 380 HCGHHRVAKV--LLDKGAKPNSR-ALNGFTPLHIACK-KNHVRVMELLLKTGASIDAVTE 435
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVG-------------- 275
G+T LH A+ + +K LL+ GASP+ + TPL+ A G
Sbjct: 436 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 495
Query: 276 ------------------GDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHL 317
G +LLL +A G +H A R GHV+ + L
Sbjct: 496 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 555
Query: 318 LFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNF 377
L A + G T LH+ A Y + A +LL R + N TP VA+ N
Sbjct: 556 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 615
Query: 378 ELAEYI 383
++ + +
Sbjct: 616 DIVKLL 621
Score = 77.8 bits (190), Expect = 9e-14
Identities = 59/215 (27%), Positives = 102/215 (47%), Gaps = 5/215 (2%)
Query: 171 IQHRLVEKITKMLDRGLDPNFHDPE-TGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAK 229
+ H ++ + +L RG P H P G TPL +AA+ + VEV ++L G + +
Sbjct: 610 VHHNNLDIVKLLLPRGGSP--HSPAWNGYTPLHIAAK-QNQVEVARSLLQYGGSANAESV 666
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHA 289
G+T LH AA+ + + LL A+ + + GLTPL+ A G P ++L+
Sbjct: 667 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA-DVLIKHGV 725
Query: 290 TVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARV 349
V G+ +H A YG+++ ++ LL + AD++A+ G + LH A +
Sbjct: 726 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 785
Query: 350 LLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIK 384
LL G + + + TP +A G + + +K
Sbjct: 786 LLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 820
Score = 75.9 bits (185), Expect = 3e-13
Identities = 58/183 (31%), Positives = 89/183 (48%), Gaps = 2/183 (1%)
Query: 201 LTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYK 260
L +AA+ DD+ L+N + D +K G T LH AA N + LL GAS ++
Sbjct: 210 LHIAARNDDTRTAAVLLQND-PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 268
Query: 261 DSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFY 320
G+TPL H A G+ LLL A + K ++ +H A R GHV+ E LL +
Sbjct: 269 PQNGITPL-HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 327
Query: 321 GADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELA 380
GA + A+ +G + +H+ A + C R+LL + + TP VA G+ +A
Sbjct: 328 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 387
Query: 381 EYI 383
+ +
Sbjct: 388 KVL 390
Score = 72.0 bits (175), Expect = 5e-12
Identities = 59/191 (30%), Positives = 82/191 (42%), Gaps = 2/191 (1%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G TPL +AA+ V V + L AH + K+G+T LH A N +K LL G S
Sbjct: 569 GFTPLHVAAKYG-KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 627
Query: 257 PDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEH 316
P G TPL H A LL + + G +H A + GH + +
Sbjct: 628 PHSPAWNGYTPL-HIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 686
Query: 317 LLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGN 376
LL A+ + N SG T LH+ A A VL+ G + TP VA GN
Sbjct: 687 LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGN 746
Query: 377 FELAEYIKNHK 387
+L +++ H+
Sbjct: 747 IKLVKFLLQHQ 757
Score = 70.1 bits (170), Expect = 2e-11
Identities = 55/210 (26%), Positives = 94/210 (44%), Gaps = 7/210 (3%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
E + ++++ G + N + G TPL +AAQ ++ +EV+K L GA+ + +DG T L
Sbjct: 125 EVVRELVNYGANVNAQS-QKGFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDGFTPLA 182
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
A + ++ + L+ G + P H A D +LL +
Sbjct: 183 VALQQGHENVVAHLINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPNPDVLSK 237
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
G+ +H A Y ++ + LL GA ++ +G T LHI + R+LL RG
Sbjct: 238 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 297
Query: 357 KELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
E K + TP A G+ ++E + +H
Sbjct: 298 IETKTKDELTPLHCAARNGHVRISEILLDH 327
Score = 63.5 bits (153), Expect = 2e-09
Identities = 61/223 (27%), Positives = 98/223 (43%), Gaps = 19/223 (8%)
Query: 163 NLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGA 222
NL K +DH+++ G+D N + + G L LA++ + V+++ L +
Sbjct: 57 NLDKALDHLRN------------GVDINTCN-QNGLNGLHLASK-EGHVKMVVELLHKEI 102
Query: 223 HLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCE 282
L+ K G TALH AA A ++ L+ GA+ + + G TPLY A +
Sbjct: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLY-MAAQENHLEVVK 161
Query: 283 LLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYN 342
LL A E+G+ + A + GH + HL+ YG + ALHI A +
Sbjct: 162 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARND 217
Query: 343 QDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKN 385
A VLL N ++ + TP +A N +A+ + N
Sbjct: 218 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 260
Score = 52.0 bits (123), Expect = 5e-06
Identities = 42/157 (26%), Positives = 70/157 (44%), Gaps = 1/157 (0%)
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHA 289
D T+ +AAR+ N L G + + GL L H A G LLH+
Sbjct: 44 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGL-HLASKEGHVKMVVELLHKEI 102
Query: 290 TVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARV 349
+ + G +H A G + + L+ YGA+++AQ+ G T L++ A N +
Sbjct: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 162
Query: 350 LLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
LL G N+ + + TP VA+ G+ + ++ N+
Sbjct: 163 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 199
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 98.6 bits (244), Expect = 5e-20
Identities = 69/202 (34%), Positives = 101/202 (50%), Gaps = 3/202 (1%)
Query: 179 ITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKA 238
+ +L RG PN + + ETPL +AA+ + EV K L A ++ +AKD T LH A
Sbjct: 420 VKNLLQRGASPNVSNVKV-ETPLHMAARAGHT-EVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Query: 239 ARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENG 298
AR + +K LLE A+P+ + G TPL H A G LL + A+ C + G
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPL-HIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 299 WHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKE 358
+ +H A +YG V+ E LL A +A +G T LH+ +N ++LL RGG+
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 359 LKNYNSQTPFQVAIIAGNFELA 380
+N TP +A E+A
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVA 618
Score = 94.0 bits (232), Expect = 1e-18
Identities = 80/284 (28%), Positives = 129/284 (45%), Gaps = 41/284 (14%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+RG NF P+ G TPL +A++ + + +++ L + GA ++ + KD +T LH AAR
Sbjct: 225 LLNRGASVNF-TPQNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHE-------------- 287
+ + LL+ GA K GL+P+ H A G C LLL
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341
Query: 288 -HATVCCKDE------------------NGWHEIHQACRYGHVQHLEHLLFYGADMSAQN 328
H C NG+ +H AC+ HV+ +E LL GA + A
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 329 ASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHKE 388
SG T LH+ + + LL RG + + N +TP +A AG+ E+A+Y+ +K
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 389 TDIVPFR--EAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNASA 430
+ + P + R N + ++LL +N++ NL +A
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMV---KLLLENNANPNLATTA 502
Score = 81.3 bits (199), Expect = 8e-15
Identities = 65/220 (29%), Positives = 97/220 (44%), Gaps = 5/220 (2%)
Query: 167 CMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDF 226
C I H + K+ +L+ +PN G TPL +AA+ + VE + AL A
Sbjct: 476 CAARIGHTNMVKL--LLENNANPNLATT-AGHTPLHIAAR-EGHVETVLALLEKEASQAC 531
Query: 227 RAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLH 286
K G T LH AA+ + LLE A P+ GLTPL H A+ + +LLL
Sbjct: 532 MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL-HVAVHHNNLDIVKLLLP 590
Query: 287 EHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSC 346
+ NG+ +H A + V+ LL YG +A++ G T LH+ A
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 347 ARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
+LL + N L N + TP + G+ +A+ + H
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Score = 77.8 bits (190), Expect = 9e-14
Identities = 68/246 (27%), Positives = 101/246 (41%), Gaps = 36/246 (14%)
Query: 170 HIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAK 229
H H V K+ +LD+G PN G TPL +A + + V V++ L GA +D +
Sbjct: 347 HCGHHRVAKV--LLDKGAKPNSR-ALNGFTPLHIACK-KNHVRVMELLLKTGASIDAVTE 402
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVG-------------- 275
G+T LH A+ + +K LL+ GASP+ + TPL+ A G
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 462
Query: 276 ------------------GDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHL 317
G +LLL +A G +H A R GHV+ + L
Sbjct: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 522
Query: 318 LFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNF 377
L A + G T LH+ A Y + A +LL R + N TP VA+ N
Sbjct: 523 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 582
Query: 378 ELAEYI 383
++ + +
Sbjct: 583 DIVKLL 588
Score = 77.8 bits (190), Expect = 9e-14
Identities = 59/215 (27%), Positives = 102/215 (47%), Gaps = 5/215 (2%)
Query: 171 IQHRLVEKITKMLDRGLDPNFHDPE-TGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAK 229
+ H ++ + +L RG P H P G TPL +AA+ + VEV ++L G + +
Sbjct: 577 VHHNNLDIVKLLLPRGGSP--HSPAWNGYTPLHIAAK-QNQVEVARSLLQYGGSANAESV 633
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHA 289
G+T LH AA+ + + LL A+ + + GLTPL+ A G P ++L+
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA-DVLIKHGV 692
Query: 290 TVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARV 349
V G+ +H A YG+++ ++ LL + AD++A+ G + LH A +
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 350 LLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIK 384
LL G + + + TP +A G + + +K
Sbjct: 753 LLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 75.9 bits (185), Expect = 3e-13
Identities = 58/183 (31%), Positives = 89/183 (48%), Gaps = 2/183 (1%)
Query: 201 LTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYK 260
L +AA+ DD+ L+N + D +K G T LH AA N + LL GAS ++
Sbjct: 177 LHIAARNDDTRTAAVLLQND-PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 261 DSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFY 320
G+TPL H A G+ LLL A + K ++ +H A R GHV+ E LL +
Sbjct: 236 PQNGITPL-HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294
Query: 321 GADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELA 380
GA + A+ +G + +H+ A + C R+LL + + TP VA G+ +A
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 381 EYI 383
+ +
Sbjct: 355 KVL 357
Score = 72.0 bits (175), Expect = 5e-12
Identities = 59/191 (30%), Positives = 82/191 (42%), Gaps = 2/191 (1%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G TPL +AA+ V V + L AH + K+G+T LH A N +K LL G S
Sbjct: 536 GFTPLHVAAKYG-KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 257 PDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEH 316
P G TPL H A LL + + G +H A + GH + +
Sbjct: 595 PHSPAWNGYTPL-HIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653
Query: 317 LLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGN 376
LL A+ + N SG T LH+ A A VL+ G + TP VA GN
Sbjct: 654 LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGN 713
Query: 377 FELAEYIKNHK 387
+L +++ H+
Sbjct: 714 IKLVKFLLQHQ 724
Score = 70.1 bits (170), Expect = 2e-11
Identities = 55/210 (26%), Positives = 94/210 (44%), Gaps = 7/210 (3%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
E + ++++ G + N + G TPL +AAQ ++ +EV+K L GA+ + +DG T L
Sbjct: 92 EVVRELVNYGANVNAQS-QKGFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
A + ++ + L+ G + P H A D +LL +
Sbjct: 150 VALQQGHENVVAHLINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
G+ +H A Y ++ + LL GA ++ +G T LHI + R+LL RG
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 357 KELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
E K + TP A G+ ++E + +H
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDH 294
Score = 63.5 bits (153), Expect = 2e-09
Identities = 61/223 (27%), Positives = 98/223 (43%), Gaps = 19/223 (8%)
Query: 163 NLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGA 222
NL K +DH+++ G+D N + + G L LA++ + V+++ L +
Sbjct: 24 NLDKALDHLRN------------GVDINTCN-QNGLNGLHLASK-EGHVKMVVELLHKEI 69
Query: 223 HLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCE 282
L+ K G TALH AA A ++ L+ GA+ + + G TPLY A +
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLY-MAAQENHLEVVK 128
Query: 283 LLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYN 342
LL A E+G+ + A + GH + HL+ YG + ALHI A +
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARND 184
Query: 343 QDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKN 385
A VLL N ++ + TP +A N +A+ + N
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Score = 55.5 bits (132), Expect = 5e-07
Identities = 44/161 (27%), Positives = 72/161 (44%), Gaps = 1/161 (0%)
Query: 226 FRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLL 285
FR D T+ +AAR+ N L G + + GL L H A G LL
Sbjct: 7 FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGL-HLASKEGHVKMVVELL 65
Query: 286 HEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDS 345
H+ + + G +H A G + + L+ YGA+++AQ+ G T L++ A N
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 346 CARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
+ LL G N+ + + TP VA+ G+ + ++ N+
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 98.6 bits (244), Expect = 5e-20
Identities = 69/202 (34%), Positives = 101/202 (50%), Gaps = 3/202 (1%)
Query: 179 ITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKA 238
+ +L RG PN + + ETPL +AA+ + EV K L A ++ +AKD T LH A
Sbjct: 420 VKNLLQRGASPNVSNVKV-ETPLHMAARAGHT-EVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Query: 239 ARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENG 298
AR + +K LLE A+P+ + G TPL H A G LL + A+ C + G
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPL-HIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 299 WHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKE 358
+ +H A +YG V+ E LL A +A +G T LH+ +N ++LL RGG+
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 359 LKNYNSQTPFQVAIIAGNFELA 380
+N TP +A E+A
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVA 618
Score = 94.0 bits (232), Expect = 1e-18
Identities = 80/284 (28%), Positives = 129/284 (45%), Gaps = 41/284 (14%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+RG NF P+ G TPL +A++ + + +++ L + GA ++ + KD +T LH AAR
Sbjct: 225 LLNRGASVNF-TPQNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHE-------------- 287
+ + LL+ GA K GL+P+ H A G C LLL
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341
Query: 288 -HATVCCKDE------------------NGWHEIHQACRYGHVQHLEHLLFYGADMSAQN 328
H C NG+ +H AC+ HV+ +E LL GA + A
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 329 ASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHKE 388
SG T LH+ + + LL RG + + N +TP +A AG+ E+A+Y+ +K
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 389 TDIVPFR--EAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNASA 430
+ + P + R N + ++LL +N++ NL +A
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMV---KLLLENNANPNLATTA 502
Score = 81.3 bits (199), Expect = 8e-15
Identities = 65/220 (29%), Positives = 97/220 (44%), Gaps = 5/220 (2%)
Query: 167 CMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDF 226
C I H + K+ +L+ +PN G TPL +AA+ + VE + AL A
Sbjct: 476 CAARIGHTNMVKL--LLENNANPNLATT-AGHTPLHIAAR-EGHVETVLALLEKEASQAC 531
Query: 227 RAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLH 286
K G T LH AA+ + LLE A P+ GLTPL H A+ + +LLL
Sbjct: 532 MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL-HVAVHHNNLDIVKLLLP 590
Query: 287 EHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSC 346
+ NG+ +H A + V+ LL YG +A++ G T LH+ A
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 347 ARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
+LL + N L N + TP + G+ +A+ + H
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Score = 77.8 bits (190), Expect = 9e-14
Identities = 68/246 (27%), Positives = 101/246 (41%), Gaps = 36/246 (14%)
Query: 170 HIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAK 229
H H V K+ +LD+G PN G TPL +A + + V V++ L GA +D +
Sbjct: 347 HCGHHRVAKV--LLDKGAKPNSR-ALNGFTPLHIACK-KNHVRVMELLLKTGASIDAVTE 402
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVG-------------- 275
G+T LH A+ + +K LL+ GASP+ + TPL+ A G
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 462
Query: 276 ------------------GDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHL 317
G +LLL +A G +H A R GHV+ + L
Sbjct: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 522
Query: 318 LFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNF 377
L A + G T LH+ A Y + A +LL R + N TP VA+ N
Sbjct: 523 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 582
Query: 378 ELAEYI 383
++ + +
Sbjct: 583 DIVKLL 588
Score = 77.8 bits (190), Expect = 9e-14
Identities = 59/215 (27%), Positives = 102/215 (47%), Gaps = 5/215 (2%)
Query: 171 IQHRLVEKITKMLDRGLDPNFHDPE-TGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAK 229
+ H ++ + +L RG P H P G TPL +AA+ + VEV ++L G + +
Sbjct: 577 VHHNNLDIVKLLLPRGGSP--HSPAWNGYTPLHIAAK-QNQVEVARSLLQYGGSANAESV 633
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHA 289
G+T LH AA+ + + LL A+ + + GLTPL+ A G P ++L+
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA-DVLIKHGV 692
Query: 290 TVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARV 349
V G+ +H A YG+++ ++ LL + AD++A+ G + LH A +
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 350 LLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIK 384
LL G + + + TP +A G + + +K
Sbjct: 753 LLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 75.9 bits (185), Expect = 3e-13
Identities = 58/183 (31%), Positives = 89/183 (48%), Gaps = 2/183 (1%)
Query: 201 LTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYK 260
L +AA+ DD+ L+N + D +K G T LH AA N + LL GAS ++
Sbjct: 177 LHIAARNDDTRTAAVLLQND-PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 261 DSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFY 320
G+TPL H A G+ LLL A + K ++ +H A R GHV+ E LL +
Sbjct: 236 PQNGITPL-HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294
Query: 321 GADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELA 380
GA + A+ +G + +H+ A + C R+LL + + TP VA G+ +A
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 381 EYI 383
+ +
Sbjct: 355 KVL 357
Score = 72.0 bits (175), Expect = 5e-12
Identities = 59/191 (30%), Positives = 82/191 (42%), Gaps = 2/191 (1%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G TPL +AA+ V V + L AH + K+G+T LH A N +K LL G S
Sbjct: 536 GFTPLHVAAKYG-KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 257 PDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEH 316
P G TPL H A LL + + G +H A + GH + +
Sbjct: 595 PHSPAWNGYTPL-HIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653
Query: 317 LLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGN 376
LL A+ + N SG T LH+ A A VL+ G + TP VA GN
Sbjct: 654 LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGN 713
Query: 377 FELAEYIKNHK 387
+L +++ H+
Sbjct: 714 IKLVKFLLQHQ 724
Score = 70.1 bits (170), Expect = 2e-11
Identities = 55/210 (26%), Positives = 94/210 (44%), Gaps = 7/210 (3%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
E + ++++ G + N + G TPL +AAQ ++ +EV+K L GA+ + +DG T L
Sbjct: 92 EVVRELVNYGANVNAQS-QKGFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
A + ++ + L+ G + P H A D +LL +
Sbjct: 150 VALQQGHENVVAHLINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
G+ +H A Y ++ + LL GA ++ +G T LHI + R+LL RG
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 357 KELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
E K + TP A G+ ++E + +H
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDH 294
Score = 63.5 bits (153), Expect = 2e-09
Identities = 61/223 (27%), Positives = 98/223 (43%), Gaps = 19/223 (8%)
Query: 163 NLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGA 222
NL K +DH+++ G+D N + + G L LA++ + V+++ L +
Sbjct: 24 NLDKALDHLRN------------GVDINTCN-QNGLNGLHLASK-EGHVKMVVELLHKEI 69
Query: 223 HLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCE 282
L+ K G TALH AA A ++ L+ GA+ + + G TPLY A +
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLY-MAAQENHLEVVK 128
Query: 283 LLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYN 342
LL A E+G+ + A + GH + HL+ YG + ALHI A +
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARND 184
Query: 343 QDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKN 385
A VLL N ++ + TP +A N +A+ + N
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Score = 55.5 bits (132), Expect = 5e-07
Identities = 44/161 (27%), Positives = 72/161 (44%), Gaps = 1/161 (0%)
Query: 226 FRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLL 285
FR D T+ +AAR+ N L G + + GL L H A G LL
Sbjct: 7 FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGL-HLASKEGHVKMVVELL 65
Query: 286 HEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDS 345
H+ + + G +H A G + + L+ YGA+++AQ+ G T L++ A N
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 346 CARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
+ LL G N+ + + TP VA+ G+ + ++ N+
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 98.6 bits (244), Expect = 5e-20
Identities = 69/202 (34%), Positives = 101/202 (50%), Gaps = 3/202 (1%)
Query: 179 ITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKA 238
+ +L RG PN + + ETPL +AA+ + EV K L A ++ +AKD T LH A
Sbjct: 420 VKNLLQRGASPNVSNVKV-ETPLHMAARAGHT-EVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Query: 239 ARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENG 298
AR + +K LLE A+P+ + G TPL H A G LL + A+ C + G
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPL-HIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 299 WHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKE 358
+ +H A +YG V+ E LL A +A +G T LH+ +N ++LL RGG+
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 359 LKNYNSQTPFQVAIIAGNFELA 380
+N TP +A E+A
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVA 618
Score = 94.0 bits (232), Expect = 1e-18
Identities = 80/284 (28%), Positives = 129/284 (45%), Gaps = 41/284 (14%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+RG NF P+ G TPL +A++ + + +++ L + GA ++ + KD +T LH AAR
Sbjct: 225 LLNRGASVNF-TPQNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHE-------------- 287
+ + LL+ GA K GL+P+ H A G C LLL
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341
Query: 288 -HATVCCKDE------------------NGWHEIHQACRYGHVQHLEHLLFYGADMSAQN 328
H C NG+ +H AC+ HV+ +E LL GA + A
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 329 ASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHKE 388
SG T LH+ + + LL RG + + N +TP +A AG+ E+A+Y+ +K
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 389 TDIVPFR--EAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNASA 430
+ + P + R N + ++LL +N++ NL +A
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMV---KLLLENNANPNLATTA 502
Score = 81.3 bits (199), Expect = 8e-15
Identities = 65/220 (29%), Positives = 97/220 (44%), Gaps = 5/220 (2%)
Query: 167 CMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDF 226
C I H + K+ +L+ +PN G TPL +AA+ + VE + AL A
Sbjct: 476 CAARIGHTNMVKL--LLENNANPNLATT-AGHTPLHIAAR-EGHVETVLALLEKEASQAC 531
Query: 227 RAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLH 286
K G T LH AA+ + LLE A P+ GLTPL H A+ + +LLL
Sbjct: 532 MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL-HVAVHHNNLDIVKLLLP 590
Query: 287 EHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSC 346
+ NG+ +H A + V+ LL YG +A++ G T LH+ A
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 347 ARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
+LL + N L N + TP + G+ +A+ + H
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Score = 77.8 bits (190), Expect = 9e-14
Identities = 68/246 (27%), Positives = 101/246 (41%), Gaps = 36/246 (14%)
Query: 170 HIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAK 229
H H V K+ +LD+G PN G TPL +A + + V V++ L GA +D +
Sbjct: 347 HCGHHRVAKV--LLDKGAKPNSR-ALNGFTPLHIACK-KNHVRVMELLLKTGASIDAVTE 402
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVG-------------- 275
G+T LH A+ + +K LL+ GASP+ + TPL+ A G
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 462
Query: 276 ------------------GDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHL 317
G +LLL +A G +H A R GHV+ + L
Sbjct: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 522
Query: 318 LFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNF 377
L A + G T LH+ A Y + A +LL R + N TP VA+ N
Sbjct: 523 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 582
Query: 378 ELAEYI 383
++ + +
Sbjct: 583 DIVKLL 588
Score = 77.8 bits (190), Expect = 9e-14
Identities = 59/215 (27%), Positives = 102/215 (47%), Gaps = 5/215 (2%)
Query: 171 IQHRLVEKITKMLDRGLDPNFHDPE-TGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAK 229
+ H ++ + +L RG P H P G TPL +AA+ + VEV ++L G + +
Sbjct: 577 VHHNNLDIVKLLLPRGGSP--HSPAWNGYTPLHIAAK-QNQVEVARSLLQYGGSANAESV 633
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHA 289
G+T LH AA+ + + LL A+ + + GLTPL+ A G P ++L+
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA-DVLIKHGV 692
Query: 290 TVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARV 349
V G+ +H A YG+++ ++ LL + AD++A+ G + LH A +
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 350 LLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIK 384
LL G + + + TP +A G + + +K
Sbjct: 753 LLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 75.9 bits (185), Expect = 3e-13
Identities = 58/183 (31%), Positives = 89/183 (48%), Gaps = 2/183 (1%)
Query: 201 LTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYK 260
L +AA+ DD+ L+N + D +K G T LH AA N + LL GAS ++
Sbjct: 177 LHIAARNDDTRTAAVLLQND-PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 261 DSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFY 320
G+TPL H A G+ LLL A + K ++ +H A R GHV+ E LL +
Sbjct: 236 PQNGITPL-HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294
Query: 321 GADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELA 380
GA + A+ +G + +H+ A + C R+LL + + TP VA G+ +A
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 381 EYI 383
+ +
Sbjct: 355 KVL 357
Score = 72.0 bits (175), Expect = 5e-12
Identities = 59/191 (30%), Positives = 82/191 (42%), Gaps = 2/191 (1%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G TPL +AA+ V V + L AH + K+G+T LH A N +K LL G S
Sbjct: 536 GFTPLHVAAKYG-KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 257 PDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEH 316
P G TPL H A LL + + G +H A + GH + +
Sbjct: 595 PHSPAWNGYTPL-HIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653
Query: 317 LLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGN 376
LL A+ + N SG T LH+ A A VL+ G + TP VA GN
Sbjct: 654 LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGN 713
Query: 377 FELAEYIKNHK 387
+L +++ H+
Sbjct: 714 IKLVKFLLQHQ 724
Score = 70.1 bits (170), Expect = 2e-11
Identities = 55/210 (26%), Positives = 94/210 (44%), Gaps = 7/210 (3%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
E + ++++ G + N + G TPL +AAQ ++ +EV+K L GA+ + +DG T L
Sbjct: 92 EVVRELVNYGANVNAQS-QKGFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
A + ++ + L+ G + P H A D +LL +
Sbjct: 150 VALQQGHENVVAHLINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
G+ +H A Y ++ + LL GA ++ +G T LHI + R+LL RG
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 357 KELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
E K + TP A G+ ++E + +H
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDH 294
Score = 63.5 bits (153), Expect = 2e-09
Identities = 61/223 (27%), Positives = 98/223 (43%), Gaps = 19/223 (8%)
Query: 163 NLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGA 222
NL K +DH+++ G+D N + + G L LA++ + V+++ L +
Sbjct: 24 NLDKALDHLRN------------GVDINTCN-QNGLNGLHLASK-EGHVKMVVELLHKEI 69
Query: 223 HLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCE 282
L+ K G TALH AA A ++ L+ GA+ + + G TPLY A +
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLY-MAAQENHLEVVK 128
Query: 283 LLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYN 342
LL A E+G+ + A + GH + HL+ YG + ALHI A +
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARND 184
Query: 343 QDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKN 385
A VLL N ++ + TP +A N +A+ + N
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Score = 55.5 bits (132), Expect = 5e-07
Identities = 44/161 (27%), Positives = 72/161 (44%), Gaps = 1/161 (0%)
Query: 226 FRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLL 285
FR D T+ +AAR+ N L G + + GL L H A G LL
Sbjct: 7 FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGL-HLASKEGHVKMVVELL 65
Query: 286 HEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDS 345
H+ + + G +H A G + + L+ YGA+++AQ+ G T L++ A N
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 346 CARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
+ LL G N+ + + TP VA+ G+ + ++ N+
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 98.6 bits (244), Expect = 5e-20
Identities = 69/202 (34%), Positives = 101/202 (50%), Gaps = 3/202 (1%)
Query: 179 ITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKA 238
+ +L RG PN + + ETPL +AA+ + EV K L A ++ +AKD T LH A
Sbjct: 420 VKNLLQRGASPNVSNVKV-ETPLHMAARAGHT-EVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Query: 239 ARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENG 298
AR + +K LLE A+P+ + G TPL H A G LL + A+ C + G
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPL-HIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 299 WHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKE 358
+ +H A +YG V+ E LL A +A +G T LH+ +N ++LL RGG+
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 359 LKNYNSQTPFQVAIIAGNFELA 380
+N TP +A E+A
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVA 618
Score = 94.0 bits (232), Expect = 1e-18
Identities = 80/284 (28%), Positives = 129/284 (45%), Gaps = 41/284 (14%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+RG NF P+ G TPL +A++ + + +++ L + GA ++ + KD +T LH AAR
Sbjct: 225 LLNRGASVNF-TPQNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHE-------------- 287
+ + LL+ GA K GL+P+ H A G C LLL
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341
Query: 288 -HATVCCKDE------------------NGWHEIHQACRYGHVQHLEHLLFYGADMSAQN 328
H C NG+ +H AC+ HV+ +E LL GA + A
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 329 ASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHKE 388
SG T LH+ + + LL RG + + N +TP +A AG+ E+A+Y+ +K
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 389 TDIVPFR--EAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNASA 430
+ + P + R N + ++LL +N++ NL +A
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMV---KLLLENNANPNLATTA 502
Score = 81.3 bits (199), Expect = 8e-15
Identities = 65/220 (29%), Positives = 97/220 (44%), Gaps = 5/220 (2%)
Query: 167 CMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDF 226
C I H + K+ +L+ +PN G TPL +AA+ + VE + AL A
Sbjct: 476 CAARIGHTNMVKL--LLENNANPNLATT-AGHTPLHIAAR-EGHVETVLALLEKEASQAC 531
Query: 227 RAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLH 286
K G T LH AA+ + LLE A P+ GLTPL H A+ + +LLL
Sbjct: 532 MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL-HVAVHHNNLDIVKLLLP 590
Query: 287 EHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSC 346
+ NG+ +H A + V+ LL YG +A++ G T LH+ A
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 347 ARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
+LL + N L N + TP + G+ +A+ + H
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Score = 77.8 bits (190), Expect = 9e-14
Identities = 68/246 (27%), Positives = 101/246 (41%), Gaps = 36/246 (14%)
Query: 170 HIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAK 229
H H V K+ +LD+G PN G TPL +A + + V V++ L GA +D +
Sbjct: 347 HCGHHRVAKV--LLDKGAKPNSR-ALNGFTPLHIACK-KNHVRVMELLLKTGASIDAVTE 402
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVG-------------- 275
G+T LH A+ + +K LL+ GASP+ + TPL+ A G
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 462
Query: 276 ------------------GDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHL 317
G +LLL +A G +H A R GHV+ + L
Sbjct: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 522
Query: 318 LFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNF 377
L A + G T LH+ A Y + A +LL R + N TP VA+ N
Sbjct: 523 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 582
Query: 378 ELAEYI 383
++ + +
Sbjct: 583 DIVKLL 588
Score = 77.8 bits (190), Expect = 9e-14
Identities = 59/215 (27%), Positives = 102/215 (47%), Gaps = 5/215 (2%)
Query: 171 IQHRLVEKITKMLDRGLDPNFHDPE-TGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAK 229
+ H ++ + +L RG P H P G TPL +AA+ + VEV ++L G + +
Sbjct: 577 VHHNNLDIVKLLLPRGGSP--HSPAWNGYTPLHIAAK-QNQVEVARSLLQYGGSANAESV 633
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHA 289
G+T LH AA+ + + LL A+ + + GLTPL+ A G P ++L+
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA-DVLIKHGV 692
Query: 290 TVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARV 349
V G+ +H A YG+++ ++ LL + AD++A+ G + LH A +
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 350 LLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIK 384
LL G + + + TP +A G + + +K
Sbjct: 753 LLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 75.9 bits (185), Expect = 3e-13
Identities = 58/183 (31%), Positives = 89/183 (48%), Gaps = 2/183 (1%)
Query: 201 LTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYK 260
L +AA+ DD+ L+N + D +K G T LH AA N + LL GAS ++
Sbjct: 177 LHIAARNDDTRTAAVLLQND-PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 261 DSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFY 320
G+TPL H A G+ LLL A + K ++ +H A R GHV+ E LL +
Sbjct: 236 PQNGITPL-HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294
Query: 321 GADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELA 380
GA + A+ +G + +H+ A + C R+LL + + TP VA G+ +A
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 381 EYI 383
+ +
Sbjct: 355 KVL 357
Score = 72.0 bits (175), Expect = 5e-12
Identities = 59/191 (30%), Positives = 82/191 (42%), Gaps = 2/191 (1%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G TPL +AA+ V V + L AH + K+G+T LH A N +K LL G S
Sbjct: 536 GFTPLHVAAKYG-KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 257 PDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEH 316
P G TPL H A LL + + G +H A + GH + +
Sbjct: 595 PHSPAWNGYTPL-HIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653
Query: 317 LLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGN 376
LL A+ + N SG T LH+ A A VL+ G + TP VA GN
Sbjct: 654 LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGN 713
Query: 377 FELAEYIKNHK 387
+L +++ H+
Sbjct: 714 IKLVKFLLQHQ 724
Score = 70.1 bits (170), Expect = 2e-11
Identities = 55/210 (26%), Positives = 94/210 (44%), Gaps = 7/210 (3%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
E + ++++ G + N + G TPL +AAQ ++ +EV+K L GA+ + +DG T L
Sbjct: 92 EVVRELVNYGANVNAQS-QKGFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
A + ++ + L+ G + P H A D +LL +
Sbjct: 150 VALQQGHENVVAHLINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
G+ +H A Y ++ + LL GA ++ +G T LHI + R+LL RG
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 357 KELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
E K + TP A G+ ++E + +H
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDH 294
Score = 63.5 bits (153), Expect = 2e-09
Identities = 61/223 (27%), Positives = 98/223 (43%), Gaps = 19/223 (8%)
Query: 163 NLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGA 222
NL K +DH+++ G+D N + + G L LA++ + V+++ L +
Sbjct: 24 NLDKALDHLRN------------GVDINTCN-QNGLNGLHLASK-EGHVKMVVELLHKEI 69
Query: 223 HLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCE 282
L+ K G TALH AA A ++ L+ GA+ + + G TPLY A +
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLY-MAAQENHLEVVK 128
Query: 283 LLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYN 342
LL A E+G+ + A + GH + HL+ YG + ALHI A +
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR----LPALHIAARND 184
Query: 343 QDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKN 385
A VLL N ++ + TP +A N +A+ + N
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Score = 55.5 bits (132), Expect = 5e-07
Identities = 44/161 (27%), Positives = 72/161 (44%), Gaps = 1/161 (0%)
Query: 226 FRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLL 285
FR D T+ +AAR+ N L G + + GL L H A G LL
Sbjct: 7 FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGL-HLASKEGHVKMVVELL 65
Query: 286 HEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDS 345
H+ + + G +H A G + + L+ YGA+++AQ+ G T L++ A N
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 346 CARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
+ LL G N+ + + TP VA+ G+ + ++ N+
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 96.3 bits (238), Expect = 2e-19
Identities = 66/202 (32%), Positives = 99/202 (49%), Gaps = 4/202 (1%)
Query: 177 EKITKML-DRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
E + ++L R DPN H+ E G+TPL +AA V ++K L + GA LD + ++ T L
Sbjct: 474 ENVARLLVSRQADPNLHEAE-GKTPLHVAAYFGH-VSLVKLLTSQGAELDAQQRNLRTPL 531
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H A A++ LL+ GA PD D G PL HTA G C++LL A++
Sbjct: 532 HLAVERGKVRAIQHLLKSGAVPDALDQSGYGPL-HTAAARGKYLICKMLLRYGASLELPT 590
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGG 355
GW +H A GH++ + L A+M A A T LH+ A + +++ LL G
Sbjct: 591 HQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGA 650
Query: 356 NKELKNYNSQTPFQVAIIAGNF 377
+ + TP +A+ F
Sbjct: 651 DPNAAEQSGWTPLHLAVQRSTF 672
Score = 79.0 bits (193), Expect = 4e-14
Identities = 62/198 (31%), Positives = 93/198 (46%), Gaps = 3/198 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L G D N D E G PL AAQ D + L + GA +D + ++G T LH AA+
Sbjct: 414 LLAHGADANRVD-EDGWAPLHFAAQNGDD-GTARLLLDHGACVDAQEREGWTPLHLAAQN 471
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ + L+ A P+ ++ G TPL H A G +LL + A + + N
Sbjct: 472 NFENVARLLVSRQADPNLHEAEGKTPL-HVAAYFGHVSLVKLLTSQGAELDAQQRNLRTP 530
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H A G V+ ++HLL GA A + SG LH A + ++LL G + EL
Sbjct: 531 LHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPT 590
Query: 362 YNSQTPFQVAIIAGNFEL 379
+ TP +A G+ E+
Sbjct: 591 HQGWTPLHLAAYKGHLEI 608
Score = 67.0 bits (162), Expect = 2e-10
Identities = 54/190 (28%), Positives = 81/190 (42%), Gaps = 4/190 (2%)
Query: 195 ETGETPLT-LAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLEL 253
E TPL L AQ SVE ++ L +D + G T L AA+ + LL
Sbjct: 360 ENKVTPLHFLVAQ--GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
Query: 254 GASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQH 313
GA + D G PL+ A GD LLL A V ++ GW +H A +
Sbjct: 418 GADANRVDEDGWAPLHFAA-QNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENV 476
Query: 314 LEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAII 373
L+ AD + A G T LH+ A + S ++L +G + + N +TP +A+
Sbjct: 477 ARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVE 536
Query: 374 AGNFELAEYI 383
G +++
Sbjct: 537 RGKVRAIQHL 546
Score = 65.1 bits (157), Expect = 6e-10
Identities = 55/208 (26%), Positives = 91/208 (43%), Gaps = 3/208 (1%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
VE++ +L +D + +G TPL +AAQ D ++ L GA + +DG L
Sbjct: 375 VEQVRLLLAHEVDVDCQTA-SGYTPLLIAAQ-DQQPDLCALLLAHGADANRVDEDGWAPL 432
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H AA+ + + LL+ GA D ++ G TPL H A LL+ A +
Sbjct: 433 HFAAQNGDDGTARLLLDHGACVDAQEREGWTPL-HLAAQNNFENVARLLVSRQADPNLHE 491
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGG 355
G +H A +GHV ++ L GA++ AQ + T LH+ + + LL G
Sbjct: 492 AEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGA 551
Query: 356 NKELKNYNSQTPFQVAIIAGNFELAEYI 383
+ + + P A G + + + +
Sbjct: 552 VPDALDQSGYGPLHTAAARGKYLICKML 579
Score = 64.3 bits (155), Expect = 1e-09
Identities = 58/202 (28%), Positives = 84/202 (41%), Gaps = 11/202 (5%)
Query: 232 MTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATV 291
+T LH + ++ LL D + + G TPL A P C LLL A
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLL-IAAQDQQPDLCALLLAHGADA 421
Query: 292 CCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLL 351
DE+GW +H A + G LL +GA + AQ G T LH+ A N ++ AR+L+
Sbjct: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481
Query: 352 FRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNH-KETDIVPFREAPAYSNRRRRPPNT 410
R + L +TP VA G+ L + + + E D R R P
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDA---------QQRNLRTPLH 532
Query: 411 LAAPRVLLRSNSDNNLNASAPD 432
LA R +R+ + + PD
Sbjct: 533 LAVERGKVRAIQHLLKSGAVPD 554
Score = 62.8 bits (151), Expect = 3e-09
Identities = 63/225 (28%), Positives = 100/225 (44%), Gaps = 9/225 (4%)
Query: 148 ASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQL 207
A LD +Q L T +L ++ V I +L G P+ D ++G PL AA
Sbjct: 518 AELDAQQ-RNLRTPLHLA-----VERGKVRAIQHLLKSGAVPDALD-QSGYGPLHTAAAR 570
Query: 208 DDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTP 267
+ + K L GA L+ G T LH AA + + L E A+ + TP
Sbjct: 571 GKYL-ICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTP 629
Query: 268 LYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQ 327
L H A G+ LL A +++GW +H A + + +LL + A++ A+
Sbjct: 630 L-HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHAR 688
Query: 328 NASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAI 372
N G T H+ AL + +VL+ G ++++ S TP Q+A+
Sbjct: 689 NKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLAL 733
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 95.9 bits (237), Expect = 3e-19
Identities = 64/189 (33%), Positives = 94/189 (49%), Gaps = 2/189 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
E+G TPL +AA + V V L N GA +DF A++G+T LH A++ N +K LL+ G
Sbjct: 210 ESGFTPLHIAAHYGN-VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 268
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
D K GLTPL H A G ELLL A + + +NG +H A + HV+ +
Sbjct: 269 GQIDAKTRDGLTPL-HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 327
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIA 374
+HLL + A + TALH+ A ++LL + N + N TP +A
Sbjct: 328 KHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKK 387
Query: 375 GNFELAEYI 383
++ E +
Sbjct: 388 NRIKVMELL 396
Score = 86.7 bits (213), Expect = 2e-16
Identities = 69/205 (33%), Positives = 95/205 (46%), Gaps = 3/205 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+RG P + G +PL +AAQ D VE +K L A +D D +TALH AA
Sbjct: 297 LLERGA-PLLARTKNGLSPLHMAAQ-GDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 354
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ K LL+ A+P+ + G TPL H A ELL+ A++ E+G
Sbjct: 355 GHYRVTKLLLDKRANPNARALNGFTPL-HIACKKNRIKVMELLVKYGASIQAITESGLTP 413
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
IH A GH+ + LL GA N G TALH+ A Q R LL G + +
Sbjct: 414 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 473
Query: 362 YNSQTPFQVAIIAGNFELAEYIKNH 386
QTP +A G E+ + + H
Sbjct: 474 REEQTPLHIASRLGKTEIVQLLLQH 498
Score = 86.3 bits (212), Expect = 3e-16
Identities = 65/212 (30%), Positives = 101/212 (47%), Gaps = 4/212 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L G P+ + GET L +AA+ VEV++ L GA +D RA++ T LH A+R
Sbjct: 429 LLQNGASPDVTNIR-GETALHMAARAGQ-VEVVRCLLRNGALVDARAREEQTPLHIASRL 486
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
++ LL+ A PD + G TPL H + G +LL A + G+
Sbjct: 487 GKTEIVQLLLQHMAHPDAATTNGYTPL-HISAREGQVDVASVLLEAGAAHSLATKKGFTP 545
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H A +YG + + LL A + +G T LH+ A Y+ A +LL +G +
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
Query: 362 YNSQTPFQVAIIAGNFELAEYIKNH-KETDIV 392
N TP +A ++A + N+ ET+IV
Sbjct: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIV 637
Score = 84.0 bits (206), Expect = 1e-15
Identities = 67/264 (25%), Positives = 115/264 (43%), Gaps = 34/264 (12%)
Query: 148 ASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQL 207
A + K + T++ + V T +L+RG +F G TPL +A++
Sbjct: 197 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDF-TARNGITPLHVASKR 255
Query: 208 DDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTP 267
++ ++K L + G +D + +DG+T LH AAR+ + ++ LLE GA + GL+P
Sbjct: 256 GNT-NMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 314
Query: 268 LY--------------------------------HTAIVGGDPYCCELLLHEHATVCCKD 295
L+ H A G +LLL + A +
Sbjct: 315 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 374
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGG 355
NG+ +H AC+ ++ +E L+ YGA + A SG T +H+ A + +LL G
Sbjct: 375 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 434
Query: 356 NKELKNYNSQTPFQVAIIAGNFEL 379
+ ++ N +T +A AG E+
Sbjct: 435 SPDVTNIRGETALHMAARAGQVEV 458
Score = 77.4 bits (189), Expect = 1e-13
Identities = 54/156 (34%), Positives = 80/156 (51%), Gaps = 3/156 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+ G + N + G TPL LA+Q + +++ L + GA++ K G+T+LH AA+
Sbjct: 627 LLNYGAETNIVTKQ-GVTPLHLASQ-EGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 684
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
L + GA D G TPL A G+ LL + A V K +NG+
Sbjct: 685 DKVNVADILTKHGADQDAHTKLGYTPLI-VACHYGNVKMVNFLLKQGANVNAKTKNGYTP 743
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHI 337
+HQA + GH + LL +GA +A A+GNTAL I
Sbjct: 744 LHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI 779
Score = 76.6 bits (187), Expect = 2e-13
Identities = 59/192 (30%), Positives = 80/192 (41%), Gaps = 2/192 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
+ G TPL +AA D+ +V L GA AK+G T LH AA+ TLL G
Sbjct: 573 KNGLTPLHVAAHYDNQ-KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYG 631
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
A + G+TPL H A G LLL + A + ++G +H A + V
Sbjct: 632 AETNIVTKQGVTPL-HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA 690
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIA 374
+ L +GAD A G T L + Y LL +G N K N TP A
Sbjct: 691 DILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQ 750
Query: 375 GNFELAEYIKNH 386
G+ + + H
Sbjct: 751 GHTHIINVLLQH 762
Score = 74.3 bits (181), Expect = 1e-12
Identities = 58/182 (31%), Positives = 80/182 (43%), Gaps = 2/182 (1%)
Query: 198 ETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASP 257
+TPL +A++L + E+++ L AH D +G T LH +AR LLE GA+
Sbjct: 477 QTPLHIASRLGKT-EIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 535
Query: 258 DYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHL 317
G TPL H A G +LLL A +NG +H A Y + + L
Sbjct: 536 SLATKKGFTPL-HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 594
Query: 318 LFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNF 377
L GA A +G T LHI A NQ A LL G + TP +A G+
Sbjct: 595 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 654
Query: 378 EL 379
++
Sbjct: 655 DM 656
Score = 73.6 bits (179), Expect = 2e-12
Identities = 56/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L++G P+ + G TPL +AA+ + +++ L N GA + K G+T LH A++
Sbjct: 594 LLEKGASPHA-TAKNGYTPLHIAAK-KNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE 651
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ + LL+ GA+ GLT L H A ++L A + G+
Sbjct: 652 GHTDMVTLLLDKGANIHMSTKSGLTSL-HLAAQEDKVNVADILTKHGADQDAHTKLGYTP 710
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+ AC YG+V+ + LL GA+++A+ +G T LH A VLL G
Sbjct: 711 LIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATT 770
Query: 362 YNSQTPFQVAIIAGNFELAEYIK 384
N T +A G + + +K
Sbjct: 771 ANGNTALAIAKRLGYISVVDTLK 793
Score = 67.4 bits (163), Expect = 1e-10
Identities = 61/224 (27%), Positives = 95/224 (42%), Gaps = 15/224 (6%)
Query: 172 QHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDG 231
Q ++ + +L+ G + + E G TPL +A Q + V L+N D + K
Sbjct: 118 QENHIDVVKYLLENGANQSTAT-EDGFTPLAVALQQGHNQAVAILLEN-----DTKGKVR 171
Query: 232 MTALHKAARARNQVALKTLLELGASPDYKDSY--------GLTPLYHTAIVGGDPYCCEL 283
+ ALH AAR + + LL+ + D + G TPL H A G+ L
Sbjct: 172 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPL-HIAAHYGNVNVATL 230
Query: 284 LLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQ 343
LL+ A V NG +H A + G+ ++ LL G + A+ G T LH A
Sbjct: 231 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 290
Query: 344 DSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHK 387
D +LL RG + N +P +A + E +++ HK
Sbjct: 291 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 334
Score = 65.9 bits (159), Expect = 4e-10
Identities = 61/223 (27%), Positives = 95/223 (42%), Gaps = 37/223 (16%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G T L +A+ L EV+K L GA+++ ++++G T L+ AA+ + +K LLE GA+
Sbjct: 76 GNTALHIAS-LAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 134
Query: 257 PDYKDSYGLTPL----------------------------YHTAIVGGDPYCCELLLH-- 286
G TPL H A D LLL
Sbjct: 135 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND 194
Query: 287 EHATVCCK------DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICAL 340
+A V K E+G+ +H A YG+V LL GA + +G T LH+ +
Sbjct: 195 HNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASK 254
Query: 341 YNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYI 383
+ ++LL RGG + K + TP A +G+ ++ E +
Sbjct: 255 RGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 297
Score = 61.2 bits (147), Expect = 9e-09
Identities = 65/245 (26%), Positives = 102/245 (41%), Gaps = 40/245 (16%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
++K+ + L G+D N + + G L LAA+ + V +++ L G+ +D K G TAL
Sbjct: 23 LDKVVEYLKGGIDINTCN-QNGLNALHLAAK-EGHVGLVQELLGRGSSVDSATKKGNTAL 80
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H A+ A +K L++ GA+ + + G TPLY A + LL A
Sbjct: 81 HIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY-MAAQENHIDVVKYLLENGANQSTAT 139
Query: 296 ENGWHEIHQACRYGHVQHLEHLL-------------------------------FYGADM 324
E+G+ + A + GH Q + LL + AD+
Sbjct: 140 EDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADV 199
Query: 325 SAQ------NASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFE 378
++ SG T LHI A Y + A +LL RG + N TP VA GN
Sbjct: 200 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 259
Query: 379 LAEYI 383
+ + +
Sbjct: 260 MVKLL 264
Score = 47.0 bits (110), Expect = 2e-04
Identities = 45/173 (26%), Positives = 72/173 (41%), Gaps = 38/173 (21%)
Query: 204 AAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSY 263
A LD VE +K GG ++ ++G+ ALH AA+ + ++ LL G+S D
Sbjct: 20 AGNLDKVVEYLK----GGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 75
Query: 264 GLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGAD 323
G T L H A + G ++L+ E GA+
Sbjct: 76 GNTAL-HIASLAGQAEVVKVLVKE---------------------------------GAN 101
Query: 324 MSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGN 376
++AQ+ +G T L++ A N + LL G N+ + TP VA+ G+
Sbjct: 102 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGH 154
Score = 36.2 bits (82), Expect = 0.30
Identities = 21/80 (26%), Positives = 37/80 (46%)
Query: 304 QACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYN 363
+A R G++ + L G D++ N +G ALH+ A + LL RG + +
Sbjct: 16 RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 75
Query: 364 SQTPFQVAIIAGNFELAEYI 383
T +A +AG E+ + +
Sbjct: 76 GNTALHIASLAGQAEVVKVL 95
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 95.9 bits (237), Expect = 3e-19
Identities = 64/189 (33%), Positives = 94/189 (49%), Gaps = 2/189 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
E+G TPL +AA + V V L N GA +DF A++G+T LH A++ N +K LL+ G
Sbjct: 231 ESGFTPLHIAAHYGN-VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
D K GLTPL H A G ELLL A + + +NG +H A + HV+ +
Sbjct: 290 GQIDAKTRDGLTPL-HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 348
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIA 374
+HLL + A + TALH+ A ++LL + N + N TP +A
Sbjct: 349 KHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKK 408
Query: 375 GNFELAEYI 383
++ E +
Sbjct: 409 NRIKVMELL 417
Score = 86.7 bits (213), Expect = 2e-16
Identities = 69/205 (33%), Positives = 95/205 (46%), Gaps = 3/205 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+RG P + G +PL +AAQ D VE +K L A +D D +TALH AA
Sbjct: 318 LLERGA-PLLARTKNGLSPLHMAAQ-GDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 375
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ K LL+ A+P+ + G TPL H A ELL+ A++ E+G
Sbjct: 376 GHYRVTKLLLDKRANPNARALNGFTPL-HIACKKNRIKVMELLVKYGASIQAITESGLTP 434
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
IH A GH+ + LL GA N G TALH+ A Q R LL G + +
Sbjct: 435 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 494
Query: 362 YNSQTPFQVAIIAGNFELAEYIKNH 386
QTP +A G E+ + + H
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQH 519
Score = 86.3 bits (212), Expect = 3e-16
Identities = 65/212 (30%), Positives = 101/212 (47%), Gaps = 4/212 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L G P+ + GET L +AA+ VEV++ L GA +D RA++ T LH A+R
Sbjct: 450 LLQNGASPDVTNIR-GETALHMAARAGQ-VEVVRCLLRNGALVDARAREEQTPLHIASRL 507
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
++ LL+ A PD + G TPL H + G +LL A + G+
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPL-HISAREGQVDVASVLLEAGAAHSLATKKGFTP 566
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H A +YG + + LL A + +G T LH+ A Y+ A +LL +G +
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 362 YNSQTPFQVAIIAGNFELAEYIKNH-KETDIV 392
N TP +A ++A + N+ ET+IV
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIV 658
Score = 84.0 bits (206), Expect = 1e-15
Identities = 67/264 (25%), Positives = 115/264 (43%), Gaps = 34/264 (12%)
Query: 148 ASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQL 207
A + K + T++ + V T +L+RG +F G TPL +A++
Sbjct: 218 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDF-TARNGITPLHVASKR 276
Query: 208 DDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTP 267
++ ++K L + G +D + +DG+T LH AAR+ + ++ LLE GA + GL+P
Sbjct: 277 GNT-NMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 335
Query: 268 LY--------------------------------HTAIVGGDPYCCELLLHEHATVCCKD 295
L+ H A G +LLL + A +
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGG 355
NG+ +H AC+ ++ +E L+ YGA + A SG T +H+ A + +LL G
Sbjct: 396 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455
Query: 356 NKELKNYNSQTPFQVAIIAGNFEL 379
+ ++ N +T +A AG E+
Sbjct: 456 SPDVTNIRGETALHMAARAGQVEV 479
Score = 77.4 bits (189), Expect = 1e-13
Identities = 54/156 (34%), Positives = 80/156 (51%), Gaps = 3/156 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+ G + N + G TPL LA+Q + +++ L + GA++ K G+T+LH AA+
Sbjct: 648 LLNYGAETNIVTKQ-GVTPLHLASQ-EGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 705
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
L + GA D G TPL A G+ LL + A V K +NG+
Sbjct: 706 DKVNVADILTKHGADQDAHTKLGYTPLI-VACHYGNVKMVNFLLKQGANVNAKTKNGYTP 764
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHI 337
+HQA + GH + LL +GA +A A+GNTAL I
Sbjct: 765 LHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI 800
Score = 76.6 bits (187), Expect = 2e-13
Identities = 59/192 (30%), Positives = 80/192 (41%), Gaps = 2/192 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
+ G TPL +AA D+ +V L GA AK+G T LH AA+ TLL G
Sbjct: 594 KNGLTPLHVAAHYDNQ-KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYG 652
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
A + G+TPL H A G LLL + A + ++G +H A + V
Sbjct: 653 AETNIVTKQGVTPL-HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA 711
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIA 374
+ L +GAD A G T L + Y LL +G N K N TP A
Sbjct: 712 DILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQ 771
Query: 375 GNFELAEYIKNH 386
G+ + + H
Sbjct: 772 GHTHIINVLLQH 783
Score = 74.3 bits (181), Expect = 1e-12
Identities = 58/182 (31%), Positives = 80/182 (43%), Gaps = 2/182 (1%)
Query: 198 ETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASP 257
+TPL +A++L + E+++ L AH D +G T LH +AR LLE GA+
Sbjct: 498 QTPLHIASRLGKT-EIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 556
Query: 258 DYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHL 317
G TPL H A G +LLL A +NG +H A Y + + L
Sbjct: 557 SLATKKGFTPL-HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615
Query: 318 LFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNF 377
L GA A +G T LHI A NQ A LL G + TP +A G+
Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 675
Query: 378 EL 379
++
Sbjct: 676 DM 677
Score = 73.6 bits (179), Expect = 2e-12
Identities = 56/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L++G P+ + G TPL +AA+ + +++ L N GA + K G+T LH A++
Sbjct: 615 LLEKGASPHA-TAKNGYTPLHIAAK-KNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE 672
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ + LL+ GA+ GLT L H A ++L A + G+
Sbjct: 673 GHTDMVTLLLDKGANIHMSTKSGLTSL-HLAAQEDKVNVADILTKHGADQDAHTKLGYTP 731
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+ AC YG+V+ + LL GA+++A+ +G T LH A VLL G
Sbjct: 732 LIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATT 791
Query: 362 YNSQTPFQVAIIAGNFELAEYIK 384
N T +A G + + +K
Sbjct: 792 ANGNTALAIAKRLGYISVVDTLK 814
Score = 67.4 bits (163), Expect = 1e-10
Identities = 61/224 (27%), Positives = 95/224 (42%), Gaps = 15/224 (6%)
Query: 172 QHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDG 231
Q ++ + +L+ G + + E G TPL +A Q + V L+N D + K
Sbjct: 139 QENHIDVVKYLLENGANQSTAT-EDGFTPLAVALQQGHNQAVAILLEN-----DTKGKVR 192
Query: 232 MTALHKAARARNQVALKTLLELGASPDYKDSY--------GLTPLYHTAIVGGDPYCCEL 283
+ ALH AAR + + LL+ + D + G TPL H A G+ L
Sbjct: 193 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPL-HIAAHYGNVNVATL 251
Query: 284 LLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQ 343
LL+ A V NG +H A + G+ ++ LL G + A+ G T LH A
Sbjct: 252 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 311
Query: 344 DSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHK 387
D +LL RG + N +P +A + E +++ HK
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355
Score = 65.9 bits (159), Expect = 4e-10
Identities = 61/223 (27%), Positives = 95/223 (42%), Gaps = 37/223 (16%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G T L +A+ L EV+K L GA+++ ++++G T L+ AA+ + +K LLE GA+
Sbjct: 97 GNTALHIAS-LAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 257 PDYKDSYGLTPL----------------------------YHTAIVGGDPYCCELLLH-- 286
G TPL H A D LLL
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND 215
Query: 287 EHATVCCK------DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICAL 340
+A V K E+G+ +H A YG+V LL GA + +G T LH+ +
Sbjct: 216 HNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASK 275
Query: 341 YNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYI 383
+ ++LL RGG + K + TP A +G+ ++ E +
Sbjct: 276 RGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
Score = 57.8 bits (138), Expect = 1e-07
Identities = 28/89 (31%), Positives = 49/89 (55%)
Query: 295 DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRG 354
++NG + +H A + GHV ++ LL G+ + + GNTALHI +L Q +VL+ G
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120
Query: 355 GNKELKNYNSQTPFQVAIIAGNFELAEYI 383
N ++ N TP +A + ++ +Y+
Sbjct: 121 ANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Score = 49.3 bits (116), Expect = 3e-05
Identities = 50/175 (28%), Positives = 78/175 (44%), Gaps = 7/175 (4%)
Query: 204 AAQLDDSVEVIKALKNGGAHLDFRAK--DGMTALHKAARARNQVALKTLLELGASPDYKD 261
AAQ DS E NG + R K D + +AARA N + L+ G + +
Sbjct: 6 AAQKSDSGEKF----NGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCN 61
Query: 262 SYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYG 321
GL L H A G + LL ++V + G +H A G + ++ L+ G
Sbjct: 62 QNGLNAL-HLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120
Query: 322 ADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGN 376
A+++AQ+ +G T L++ A N + LL G N+ + TP VA+ G+
Sbjct: 121 ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGH 175
Score = 36.2 bits (82), Expect = 0.30
Identities = 21/80 (26%), Positives = 37/80 (46%)
Query: 304 QACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYN 363
+A R G++ + L G D++ N +G ALH+ A + LL RG + +
Sbjct: 37 RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96
Query: 364 SQTPFQVAIIAGNFELAEYI 383
T +A +AG E+ + +
Sbjct: 97 GNTALHIASLAGQAEVVKVL 116
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 95.9 bits (237), Expect = 3e-19
Identities = 64/189 (33%), Positives = 94/189 (49%), Gaps = 2/189 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
E+G TPL +AA + V V L N GA +DF A++G+T LH A++ N +K LL+ G
Sbjct: 231 ESGFTPLHIAAHYGN-VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
D K GLTPL H A G ELLL A + + +NG +H A + HV+ +
Sbjct: 290 GQIDAKTRDGLTPL-HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 348
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIA 374
+HLL + A + TALH+ A ++LL + N + N TP +A
Sbjct: 349 KHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKK 408
Query: 375 GNFELAEYI 383
++ E +
Sbjct: 409 NRIKVMELL 417
Score = 86.7 bits (213), Expect = 2e-16
Identities = 69/205 (33%), Positives = 95/205 (46%), Gaps = 3/205 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+RG P + G +PL +AAQ D VE +K L A +D D +TALH AA
Sbjct: 318 LLERGA-PLLARTKNGLSPLHMAAQ-GDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 375
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ K LL+ A+P+ + G TPL H A ELL+ A++ E+G
Sbjct: 376 GHYRVTKLLLDKRANPNARALNGFTPL-HIACKKNRIKVMELLVKYGASIQAITESGLTP 434
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
IH A GH+ + LL GA N G TALH+ A Q R LL G + +
Sbjct: 435 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 494
Query: 362 YNSQTPFQVAIIAGNFELAEYIKNH 386
QTP +A G E+ + + H
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQH 519
Score = 86.3 bits (212), Expect = 3e-16
Identities = 65/212 (30%), Positives = 101/212 (47%), Gaps = 4/212 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L G P+ + GET L +AA+ VEV++ L GA +D RA++ T LH A+R
Sbjct: 450 LLQNGASPDVTNIR-GETALHMAARAGQ-VEVVRCLLRNGALVDARAREEQTPLHIASRL 507
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
++ LL+ A PD + G TPL H + G +LL A + G+
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPL-HISAREGQVDVASVLLEAGAAHSLATKKGFTP 566
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H A +YG + + LL A + +G T LH+ A Y+ A +LL +G +
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 362 YNSQTPFQVAIIAGNFELAEYIKNH-KETDIV 392
N TP +A ++A + N+ ET+IV
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIV 658
Score = 84.0 bits (206), Expect = 1e-15
Identities = 67/264 (25%), Positives = 115/264 (43%), Gaps = 34/264 (12%)
Query: 148 ASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQL 207
A + K + T++ + V T +L+RG +F G TPL +A++
Sbjct: 218 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDF-TARNGITPLHVASKR 276
Query: 208 DDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTP 267
++ ++K L + G +D + +DG+T LH AAR+ + ++ LLE GA + GL+P
Sbjct: 277 GNT-NMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 335
Query: 268 LY--------------------------------HTAIVGGDPYCCELLLHEHATVCCKD 295
L+ H A G +LLL + A +
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGG 355
NG+ +H AC+ ++ +E L+ YGA + A SG T +H+ A + +LL G
Sbjct: 396 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455
Query: 356 NKELKNYNSQTPFQVAIIAGNFEL 379
+ ++ N +T +A AG E+
Sbjct: 456 SPDVTNIRGETALHMAARAGQVEV 479
Score = 77.4 bits (189), Expect = 1e-13
Identities = 54/156 (34%), Positives = 80/156 (51%), Gaps = 3/156 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+ G + N + G TPL LA+Q + +++ L + GA++ K G+T+LH AA+
Sbjct: 648 LLNYGAETNIVTKQ-GVTPLHLASQ-EGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 705
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
L + GA D G TPL A G+ LL + A V K +NG+
Sbjct: 706 DKVNVADILTKHGADQDAHTKLGYTPLI-VACHYGNVKMVNFLLKQGANVNAKTKNGYTP 764
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHI 337
+HQA + GH + LL +GA +A A+GNTAL I
Sbjct: 765 LHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI 800
Score = 76.6 bits (187), Expect = 2e-13
Identities = 59/192 (30%), Positives = 80/192 (41%), Gaps = 2/192 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
+ G TPL +AA D+ +V L GA AK+G T LH AA+ TLL G
Sbjct: 594 KNGLTPLHVAAHYDNQ-KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYG 652
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
A + G+TPL H A G LLL + A + ++G +H A + V
Sbjct: 653 AETNIVTKQGVTPL-HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA 711
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIA 374
+ L +GAD A G T L + Y LL +G N K N TP A
Sbjct: 712 DILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQ 771
Query: 375 GNFELAEYIKNH 386
G+ + + H
Sbjct: 772 GHTHIINVLLQH 783
Score = 74.3 bits (181), Expect = 1e-12
Identities = 58/182 (31%), Positives = 80/182 (43%), Gaps = 2/182 (1%)
Query: 198 ETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASP 257
+TPL +A++L + E+++ L AH D +G T LH +AR LLE GA+
Sbjct: 498 QTPLHIASRLGKT-EIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 556
Query: 258 DYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHL 317
G TPL H A G +LLL A +NG +H A Y + + L
Sbjct: 557 SLATKKGFTPL-HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615
Query: 318 LFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNF 377
L GA A +G T LHI A NQ A LL G + TP +A G+
Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 675
Query: 378 EL 379
++
Sbjct: 676 DM 677
Score = 73.6 bits (179), Expect = 2e-12
Identities = 56/203 (27%), Positives = 92/203 (45%), Gaps = 3/203 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L++G P+ + G TPL +AA+ + +++ L N GA + K G+T LH A++
Sbjct: 615 LLEKGASPHA-TAKNGYTPLHIAAK-KNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE 672
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ + LL+ GA+ GLT L H A ++L A + G+
Sbjct: 673 GHTDMVTLLLDKGANIHMSTKSGLTSL-HLAAQEDKVNVADILTKHGADQDAHTKLGYTP 731
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+ AC YG+V+ + LL GA+++A+ +G T LH A VLL G
Sbjct: 732 LIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATT 791
Query: 362 YNSQTPFQVAIIAGNFELAEYIK 384
N T +A G + + +K
Sbjct: 792 ANGNTALAIAKRLGYISVVDTLK 814
Score = 67.4 bits (163), Expect = 1e-10
Identities = 61/224 (27%), Positives = 95/224 (42%), Gaps = 15/224 (6%)
Query: 172 QHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDG 231
Q ++ + +L+ G + + E G TPL +A Q + V L+N D + K
Sbjct: 139 QENHIDVVKYLLENGANQSTAT-EDGFTPLAVALQQGHNQAVAILLEN-----DTKGKVR 192
Query: 232 MTALHKAARARNQVALKTLLELGASPDYKDSY--------GLTPLYHTAIVGGDPYCCEL 283
+ ALH AAR + + LL+ + D + G TPL H A G+ L
Sbjct: 193 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPL-HIAAHYGNVNVATL 251
Query: 284 LLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQ 343
LL+ A V NG +H A + G+ ++ LL G + A+ G T LH A
Sbjct: 252 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 311
Query: 344 DSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHK 387
D +LL RG + N +P +A + E +++ HK
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355
Score = 65.9 bits (159), Expect = 4e-10
Identities = 61/223 (27%), Positives = 95/223 (42%), Gaps = 37/223 (16%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G T L +A+ L EV+K L GA+++ ++++G T L+ AA+ + +K LLE GA+
Sbjct: 97 GNTALHIAS-LAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 257 PDYKDSYGLTPL----------------------------YHTAIVGGDPYCCELLLH-- 286
G TPL H A D LLL
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND 215
Query: 287 EHATVCCK------DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICAL 340
+A V K E+G+ +H A YG+V LL GA + +G T LH+ +
Sbjct: 216 HNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASK 275
Query: 341 YNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYI 383
+ ++LL RGG + K + TP A +G+ ++ E +
Sbjct: 276 RGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
Score = 57.8 bits (138), Expect = 1e-07
Identities = 28/89 (31%), Positives = 49/89 (55%)
Query: 295 DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRG 354
++NG + +H A + GHV ++ LL G+ + + GNTALHI +L Q +VL+ G
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120
Query: 355 GNKELKNYNSQTPFQVAIIAGNFELAEYI 383
N ++ N TP +A + ++ +Y+
Sbjct: 121 ANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Score = 49.3 bits (116), Expect = 3e-05
Identities = 50/175 (28%), Positives = 78/175 (44%), Gaps = 7/175 (4%)
Query: 204 AAQLDDSVEVIKALKNGGAHLDFRAK--DGMTALHKAARARNQVALKTLLELGASPDYKD 261
AAQ DS E NG + R K D + +AARA N + L+ G + +
Sbjct: 6 AAQKSDSGEKF----NGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCN 61
Query: 262 SYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYG 321
GL L H A G + LL ++V + G +H A G + ++ L+ G
Sbjct: 62 QNGLNAL-HLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120
Query: 322 ADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGN 376
A+++AQ+ +G T L++ A N + LL G N+ + TP VA+ G+
Sbjct: 121 ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGH 175
Score = 36.2 bits (82), Expect = 0.30
Identities = 21/80 (26%), Positives = 37/80 (46%)
Query: 304 QACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYN 363
+A R G++ + L G D++ N +G ALH+ A + LL RG + +
Sbjct: 37 RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96
Query: 364 SQTPFQVAIIAGNFELAEYI 383
T +A +AG E+ + +
Sbjct: 97 GNTALHIASLAGQAEVVKVL 116
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 94.0 bits (232), Expect = 1e-18
Identities = 74/251 (29%), Positives = 115/251 (45%), Gaps = 5/251 (1%)
Query: 132 GVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRL--VEKITKMLDRGLDP 189
G L KK K L K A + T H+ + V +++++ G P
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 459
Query: 190 NFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKT 249
N + GET L +AA+ EV++ L GA ++ +AKD T LH +AR ++
Sbjct: 460 NTTNVR-GETALHMAAR-SGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 517
Query: 250 LLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYG 309
LL+ GASP+ + G TPL+ +A G + LL H A++ + G+ +H A +YG
Sbjct: 518 LLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH-GASLSITTKKGFTPLHVAAKYG 576
Query: 310 HVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQ 369
++ LL A A SG T LH+ A Y+ A +LL +G + N TP
Sbjct: 577 KLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLH 636
Query: 370 VAIIAGNFELA 380
+A ++A
Sbjct: 637 IAAKKNQMDIA 647
Score = 90.5 bits (223), Expect = 1e-17
Identities = 64/207 (30%), Positives = 95/207 (45%), Gaps = 2/207 (0%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
E++ +ML P + G +PL +A Q D + ++ L +D D +TALH
Sbjct: 314 EQVVEMLLDRAAPILSKTKNGLSPLHMATQ-GDHLNCVQLLLQHNVPVDDVTNDYLTALH 372
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
AA + K LL+ A+P+ K G TPL H A ELLL A++ E
Sbjct: 373 VAAHCGHYKVAKVLLDKKANPNAKALNGFTPL-HIACKKNRIKVMELLLKHGASIQAVTE 431
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
+G IH A GHV + L+ +GA + N G TALH+ A Q R L+ G
Sbjct: 432 SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQ 491
Query: 357 KELKNYNSQTPFQVAIIAGNFELAEYI 383
E K + QTP ++ G ++ + +
Sbjct: 492 VEAKAKDDQTPLHISARLGKADIVQQL 518
Score = 89.0 bits (219), Expect = 4e-17
Identities = 61/194 (31%), Positives = 92/194 (47%), Gaps = 2/194 (1%)
Query: 193 DPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLE 252
+ ++G TPL +AA + + V L N A +DF A++ +T LH A++ N +K LL+
Sbjct: 231 ESKSGFTPLHIAAHYGN-INVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLD 289
Query: 253 LGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQ 312
GA D K GLTPL H G E+LL A + K +NG +H A + H+
Sbjct: 290 RGAKIDAKTRDGLTPL-HCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLN 348
Query: 313 HLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAI 372
++ LL + + TALH+ A A+VLL + N K N TP +A
Sbjct: 349 CVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIAC 408
Query: 373 IAGNFELAEYIKNH 386
++ E + H
Sbjct: 409 KKNRIKVMELLLKH 422
Score = 83.2 bits (204), Expect = 2e-15
Identities = 64/205 (31%), Positives = 91/205 (44%), Gaps = 3/205 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+LD G + + G TPL +AA+ +EV L A D K G+T LH AA
Sbjct: 551 LLDHGASLSI-TTKKGFTPLHVAAKYG-KLEVANLLLQKSASPDAAGKSGLTPLHVAAHY 608
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
NQ LL+ GASP G TPL H A LL A G
Sbjct: 609 DNQKVALLLLDQGASPHAAAKNGYTPL-HIAAKKNQMDIATTLLEYGADANAVTRQGIAS 667
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H A + GHV + LL A+++ N SG T LH+ A ++ + A VL+ +G + + +
Sbjct: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 727
Query: 362 YNSQTPFQVAIIAGNFELAEYIKNH 386
TP V GN ++ ++ H
Sbjct: 728 KMGYTPLHVGCHYGNIKIVNFLLQH 752
Score = 79.3 bits (194), Expect = 3e-14
Identities = 67/256 (26%), Positives = 117/256 (45%), Gaps = 5/256 (1%)
Query: 133 VPSLEFRYKKRVYKQASL--DEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPN 190
+P+L +K K A+L A + +K+ + + T +L+R +
Sbjct: 203 LPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVD 262
Query: 191 FHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTL 250
F TPL +A++ ++ ++K L + GA +D + +DG+T LH AR+ ++ ++ L
Sbjct: 263 F-TARNDITPLHVASKRGNA-NMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEML 320
Query: 251 LELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGH 310
L+ A K GL+PL H A G C +LLL + V + +H A GH
Sbjct: 321 LDRAAPILSKTKNGLSPL-HMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGH 379
Query: 311 VQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
+ + LL A+ +A+ +G T LHI N+ +LL G + + + TP V
Sbjct: 380 YKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHV 439
Query: 371 AIIAGNFELAEYIKNH 386
A G+ + + +H
Sbjct: 440 AAFMGHVNIVSQLMHH 455
Score = 78.2 bits (191), Expect = 7e-14
Identities = 66/242 (27%), Positives = 106/242 (43%), Gaps = 12/242 (4%)
Query: 170 HIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAK 229
H H V K+ +LD+ +PN G TPL +A + + ++V++ L GA + +
Sbjct: 376 HCGHYKVAKV--LLDKKANPNAK-ALNGFTPLHIACK-KNRIKVMELLLKHGASIQAVTE 431
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHA 289
G+T +H AA + + L+ GASP+ + G T L H A G L+ + A
Sbjct: 432 SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETAL-HMAARSGQAEVVRYLVQDGA 490
Query: 290 TVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARV 349
V K ++ +H + R G ++ LL GA +A SG T LH+ A + A
Sbjct: 491 QVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAF 550
Query: 350 LLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHK-------ETDIVPFREAPAYSN 402
LL G + + TP VA G E+A + ++ + P A Y N
Sbjct: 551 LLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDN 610
Query: 403 RR 404
++
Sbjct: 611 QK 612
Score = 72.0 bits (175), Expect = 5e-12
Identities = 53/203 (26%), Positives = 96/203 (47%), Gaps = 3/203 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+LD+G P+ + G TPL +AA+ + +++ L GA + + G+ ++H AA+
Sbjct: 617 LLDQGASPHAA-AKNGYTPLHIAAK-KNQMDIATTLLEYGADANAVTRQGIASVHLAAQE 674
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ + LL A+ + + GLTPL H A E+L+++ A V + + G+
Sbjct: 675 GHVDMVSLLLGRNANVNLSNKSGLTPL-HLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTP 733
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H C YG+++ + LL + A ++A+ +G T LH A VLL +
Sbjct: 734 LHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELT 793
Query: 362 YNSQTPFQVAIIAGNFELAEYIK 384
N T +A G + + +K
Sbjct: 794 VNGNTALGIARRLGYISVVDTLK 816
Score = 68.6 bits (166), Expect = 6e-11
Identities = 70/271 (25%), Positives = 118/271 (43%), Gaps = 35/271 (12%)
Query: 141 KKRVYKQASLDEKQLAKLHTKT-------NLKKCMDHIQHRL------------------ 175
KKR +++ S D K+ + + +L+K +D+I++ +
Sbjct: 24 KKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASK 83
Query: 176 ---VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGM 232
VE ++++L R + + + G T L +A+ L EV+K L GA+++ ++++G
Sbjct: 84 EGHVEVVSELLQREANVDAATKK-GNTALHIAS-LAGQAEVVKVLVTNGANVNAQSQNGF 141
Query: 233 TALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVC 292
T L+ AA+ + +K LL+ GAS G TPL A+ G LLL
Sbjct: 142 TPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPL-AVALQQGHDQVVSLLLENDT--- 197
Query: 293 CKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLF 352
K + +H A R + LL + ++ SG T LHI A Y + A +LL
Sbjct: 198 -KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLN 256
Query: 353 RGGNKELKNYNSQTPFQVAIIAGNFELAEYI 383
R + N TP VA GN + + +
Sbjct: 257 RAAAVDFTARNDITPLHVASKRGNANMVKLL 287
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 86.7 bits (213), Expect = 2e-16
Identities = 79/282 (28%), Positives = 124/282 (43%), Gaps = 39/282 (13%)
Query: 126 PQPVGEGVPSLEFRYKKRVYKQA--SLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKML 183
P +G P L K + A +LD ++ KL + + K+ + ++K+ ML
Sbjct: 701 PAGLGRPTPGLSQGPGKETLESALIALDSEKPKKL--RFHPKQLYFSARQGELQKVLLML 758
Query: 184 DRGLDPNFH-DPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARAR 242
G+DPNF + + +PL AA+ V++ L GA++D ++D T L +AA
Sbjct: 759 VDGIDPNFKMEHQNKRSPLHAAAEA-GHVDICHMLVQAGANIDTCSEDQRTPLMEAAENN 817
Query: 243 NQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEI 302
+ A+K L++ GA D KD+ G T L+ A G LL + V C+D+ GW +
Sbjct: 818 HLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPM 877
Query: 303 HQACRYGHVQHLEHLLFYGADMS---------------------------------AQNA 329
A Y HV ++ LL G+D++ A N
Sbjct: 878 IWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNI 937
Query: 330 SGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVA 371
G++ LHI A N+ C + L R + LKN +TP Q A
Sbjct: 938 HGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
Score = 35.0 bits (79), Expect = 0.68
Identities = 22/96 (22%), Positives = 42/96 (43%)
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGG 355
+N +H A GHV L+ GA++ + T L A N + L+ G
Sbjct: 771 QNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGA 830
Query: 356 NKELKNYNSQTPFQVAIIAGNFELAEYIKNHKETDI 391
+ K+ T +A G++E+ +Y+ ++ + D+
Sbjct: 831 LVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDV 866
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 85.9 bits (211), Expect = 3e-16
Identities = 65/213 (30%), Positives = 101/213 (47%), Gaps = 6/213 (2%)
Query: 175 LVEKITKMLDRGLDPNFHDPET-GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMT 233
++ + +LD G+D N +P G TPL +A V V+ L + GA ++ + + G T
Sbjct: 218 MISVVKYLLDLGVDMN--EPNAYGNTPLHVACYNGQDV-VVNELIDCGAIVNQKNEKGFT 274
Query: 234 ALH-KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVC 292
LH AA + L+ L+ GA + K G TPL+ TA+ G + ++ A +
Sbjct: 275 PLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRS-QTIIQSGAVID 333
Query: 293 CKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLF 352
C+D+NG +H A RYGH + L+ GAD + + G LH+ AL C R LL
Sbjct: 334 CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS 393
Query: 353 RGGNKELKNYNSQTPFQVAIIAGNFELAEYIKN 385
G + + + +T A GN E + N
Sbjct: 394 SGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLN 426
Score = 80.1 bits (196), Expect = 2e-14
Identities = 63/226 (27%), Positives = 105/226 (46%), Gaps = 7/226 (3%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
+++ ++ + D NF D E TPL AA L D+ E+I+ L GA ++ + +T LH
Sbjct: 22 DEVRALIFKKEDVNFQDNEK-RTPLHAAAYLGDA-EIIELLILSGARVNAKDSKWLTPLH 79
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
+A + ++ A++ LL+ A + +D TPL H A C E L+ + V D
Sbjct: 80 RAVASCSEEAVQVLLKHSADVNARDKNWQTPL-HIAAANKAVKCAEALVPLLSNVNVSDR 138
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
G +H A GH + ++ LL GA+++A + A+H A ++L+ G
Sbjct: 139 AGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAE 198
Query: 357 KELKNYNSQTPFQVAIIAGNFELAEYIKNHKETDIVPFREAPAYSN 402
K+ S TP A +G + +Y+ + V E AY N
Sbjct: 199 VTCKDKKSYTPLHAAASSGMISVVKYLLDLG----VDMNEPNAYGN 240
Score = 78.2 bits (191), Expect = 7e-14
Identities = 63/224 (28%), Positives = 102/224 (45%), Gaps = 14/224 (6%)
Query: 181 KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAAR 240
K+L G D + D + G T L AA ++E + L N GA + + K G + LH AA
Sbjct: 390 KLLSSGFDIDTPD-DFGRTCLHAAAA-GGNLECLNLLLNTGADFNKKDKFGRSPLHYAAA 447
Query: 241 ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWH 300
N L L+ GAS + D G TPL++ A D C E LL A +D+ G++
Sbjct: 448 NCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYN 507
Query: 301 EIHQACRYGHVQHLEHLL----------FYGADM--SAQNASGNTALHICALYNQDSCAR 348
+H + YGH L+ + G DM + N + + LH+ A +
Sbjct: 508 AVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALE 567
Query: 349 VLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHKETDIV 392
VL+ + +++N + +TP +A G+ E + + N + +V
Sbjct: 568 VLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
Score = 77.8 bits (190), Expect = 9e-14
Identities = 52/200 (26%), Positives = 90/200 (45%), Gaps = 2/200 (1%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
+E + ++ G + D ++ TPL AA + V+K L + G ++ G T L
Sbjct: 186 IEVVKLLVSHGAEVTCKDKKS-YTPLHAAAS-SGMISVVKYLLDLGVDMNEPNAYGNTPL 243
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H A V + L++ GA + K+ G TPL+ A C ELL+ A V K
Sbjct: 244 HVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKS 303
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGG 355
++G +H +G + ++ GA + ++ +GNT LHI A Y + L+ G
Sbjct: 304 KDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGA 363
Query: 356 NKELKNYNSQTPFQVAIIAG 375
+ + + P +A ++G
Sbjct: 364 DTAKRGIHGMFPLHLAALSG 383
Score = 77.4 bits (189), Expect = 1e-13
Identities = 66/221 (29%), Positives = 100/221 (45%), Gaps = 12/221 (5%)
Query: 151 DEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDS 210
D K L LH + C + E + +L D N D + +TPL +AA + +
Sbjct: 71 DSKWLTPLHRA--VASCSE-------EAVQVLLKHSADVNARD-KNWQTPLHIAAA-NKA 119
Query: 211 VEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYH 270
V+ +AL ++++ + G TALH AA + + +K LL GA+ + D + H
Sbjct: 120 VKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAI-H 178
Query: 271 TAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNAS 330
A G +LL+ A V CKD+ + +H A G + +++LL G DM+ NA
Sbjct: 179 WAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAY 238
Query: 331 GNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVA 371
GNT LH+ QD L+ G KN TP A
Sbjct: 239 GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFA 279
Score = 71.2 bits (173), Expect = 9e-12
Identities = 55/190 (28%), Positives = 86/190 (45%), Gaps = 3/190 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
++ G D N + G+TPL + A L + + GA +D K+G T LH AAR
Sbjct: 292 LVGNGADVNMKSKD-GKTPLHMTA-LHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARY 349
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+++ + TL+ GA + +G+ PL H A + G CC LL + D+ G
Sbjct: 350 GHELLINTLITSGADTAKRGIHGMFPL-HLAALSGFSDCCRKLLSSGFDIDTPDDFGRTC 408
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H A G+++ L LL GAD + ++ G + LH A C L+ G + +
Sbjct: 409 LHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLD 468
Query: 362 YNSQTPFQVA 371
TP A
Sbjct: 469 ERGCTPLHYA 478
Score = 68.9 bits (167), Expect = 4e-11
Identities = 55/200 (27%), Positives = 84/200 (42%), Gaps = 2/200 (1%)
Query: 179 ITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKA 238
+ +++D G N + E G TPL AA ++ L GA ++ ++KDG T LH
Sbjct: 255 VNELIDCGAIVNQKN-EKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMT 313
Query: 239 ARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENG 298
A +T+++ GA D +D G TPL H A G L+ A + +G
Sbjct: 314 ALHGRFSRSQTIIQSGAVIDCEDKNGNTPL-HIAARYGHELLINTLITSGADTAKRGIHG 372
Query: 299 WHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKE 358
+H A G LL G D+ + G T LH A C +LL G +
Sbjct: 373 MFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN 432
Query: 359 LKNYNSQTPFQVAIIAGNFE 378
K+ ++P A N++
Sbjct: 433 KKDKFGRSPLHYAAANCNYQ 452
Score = 66.2 bits (160), Expect = 3e-10
Identities = 56/197 (28%), Positives = 91/197 (46%), Gaps = 11/197 (5%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G+TPL L+ L+ + + +L N GA++D + K G TALH+ A ++ + LL+ GA
Sbjct: 653 GQTPLMLSV-LNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAK 711
Query: 257 PDYKDSYGLTPLYHTAIVGGDPYCCELL---LHEHATVCCKDENGWHEIHQACRYGHVQH 313
+DS G TP++ +A G LL A D +G+ +H AC GH
Sbjct: 712 CLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETC 771
Query: 314 LEHLLFYGADMSAQNASGN--TALHICALYNQDSCARVLLFRGGNKELKNYNS--QTPFQ 369
+E LL Q GN + LH + + + A +L+ G + +S +TP
Sbjct: 772 VELLL---EQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLH 828
Query: 370 VAIIAGNFELAEYIKNH 386
A + E + + +H
Sbjct: 829 AAAFTDHVECLQLLLSH 845
Score = 63.2 bits (152), Expect = 2e-09
Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 1/189 (0%)
Query: 198 ETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASP 257
+ P + A + + ++AL ++F+ + T LH AA + ++ L+ GA
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
Query: 258 DYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHL 317
+ KDS LTPL H A+ ++LL A V +D+N +H A V+ E L
Sbjct: 68 NAKDSKWLTPL-HRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
Query: 318 LFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNF 377
+ ++++ + +G TALH A ++LL RG N + + A G+
Sbjct: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186
Query: 378 ELAEYIKNH 386
E+ + + +H
Sbjct: 187 EVVKLLVSH 195
Score = 58.5 bits (140), Expect = 6e-08
Identities = 51/181 (28%), Positives = 75/181 (41%), Gaps = 4/181 (2%)
Query: 199 TPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPD 258
+PL LAA + ++ L LD R G T L AA + + L+ GAS
Sbjct: 552 SPLHLAAYHGHH-QALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610
Query: 259 YKDSYGLTPLYHTAIVGGDPYCCELLL---HEHATVCCKDENGWHEIHQACRYGHVQHLE 315
KD H A G C LL+ V +D NG + + GH +
Sbjct: 611 VKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670
Query: 316 HLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAG 375
LL GA++ A++ G TALH A+ + C LL G L++ +TP ++ G
Sbjct: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730
Query: 376 N 376
+
Sbjct: 731 H 731
Score = 52.0 bits (123), Expect = 5e-06
Identities = 43/159 (27%), Positives = 72/159 (45%), Gaps = 5/159 (3%)
Query: 232 MTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATV 291
++ LH AA + AL+ L++ D ++S G TPL A G C ++L+++ A++
Sbjct: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPL-DLAAFKGHVECVDVLINQGASI 609
Query: 292 CCKDENGWHE-IHQACRYGHVQHLEHLLFYGADMSA---QNASGNTALHICALYNQDSCA 347
KD IH A GH + L L+ +A Q+ +G T L + L C
Sbjct: 610 LVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCV 669
Query: 348 RVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
LL +G N + K+ +T + G+ E + + H
Sbjct: 670 YSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQH 708
Score = 43.5 bits (101), Expect = 0.002
Identities = 41/140 (29%), Positives = 58/140 (41%), Gaps = 3/140 (2%)
Query: 231 GMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHAT 290
G T LH AA + L+ LL A + DS G TPL A G L+ A
Sbjct: 823 GRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAE 882
Query: 291 VCCKDENGWHEIHQACRYGHVQHLEHLLFYGAD---MSAQNASGNTALHICALYNQDSCA 347
+ +D + +H AC GH +L D ++A NA+ T LH+ A
Sbjct: 883 LTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVV 942
Query: 348 RVLLFRGGNKELKNYNSQTP 367
+ LL +G + + N TP
Sbjct: 943 QELLGKGASVLAVDENGYTP 962
Score = 38.1 bits (87), Expect = 0.080
Identities = 36/127 (28%), Positives = 56/127 (44%), Gaps = 5/127 (3%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
VE + +L N D TG+TPL +AA+ + V + + A L + TAL
Sbjct: 836 VECLQLLLSHNAQVNSVD-STGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTAL 894
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGL---TPLYHTAIVGGDPYCCELLLHEHATVC 292
H A ++ + +LE + ++ TPL H A G + LL + A+V
Sbjct: 895 HLACSKGHETSALLILEKITDRNLINATNAALQTPL-HVAARNGLTMVVQELLGKGASVL 953
Query: 293 CKDENGW 299
DENG+
Sbjct: 954 AVDENGY 960
>gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]
Length = 319
Score = 85.1 bits (209), Expect = 6e-16
Identities = 75/282 (26%), Positives = 131/282 (46%), Gaps = 23/282 (8%)
Query: 109 NGRDGKFLDEERLLREYPQPVG----EGVPSL--------EFRYKKRVYKQASLDEKQLA 156
NG G+FL E+ EY V E + +L E ++K ++A L +K+L
Sbjct: 17 NGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQWKSEKQREAELKKKKLE 76
Query: 157 KLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETG------ETPLTLAAQLDDS 210
+ NL+ IQ + +K K P +PE + P L A L++
Sbjct: 77 QRSKLENLEDLEIIIQLKKRKKYRKTKV----PVVKEPEPEIITEPVDVPTFLKAALENK 132
Query: 211 VEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYH 270
+ V++ + + D + TALH+A + ++ L+E GA +++D T + H
Sbjct: 133 LPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAI-H 191
Query: 271 TAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNAS 330
A GG+ +LLL++ A + +D+ +H A R GH + EHL+ AD++A++
Sbjct: 192 WASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDRE 251
Query: 331 GNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAI 372
G+T LH N+ R+L+ G + +KN +TP + +
Sbjct: 252 GDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVL 293
Score = 42.4 bits (98), Expect = 0.004
Identities = 24/89 (26%), Positives = 45/89 (50%)
Query: 295 DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRG 354
DE +H+AC GH+ +E L+ GA + ++ +TA+H + ++LL +G
Sbjct: 150 DEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKG 209
Query: 355 GNKELKNYNSQTPFQVAIIAGNFELAEYI 383
++ T VA+ G++E AE++
Sbjct: 210 AKISARDKLLSTALHVAVRTGHYECAEHL 238
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 84.7 bits (208), Expect = 7e-16
Identities = 65/212 (30%), Positives = 103/212 (48%), Gaps = 5/212 (2%)
Query: 172 QHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDG 231
QHR V ++ + + D N+ + L +AA SVE + L GA+ +++ G
Sbjct: 42 QHRSVSEL--LSNSKFDVNYAFGRVKRSLLHIAANCG-SVECLVLLLKKGANPNYQDISG 98
Query: 232 MTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATV 291
T LH AAR + + LLE A + ++ GLT ++ A+ G +L+ H + V
Sbjct: 99 CTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHV-SDV 157
Query: 292 CCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLL 351
+D G +H AC+ GH ++ LL GAD++ N SG T L+ + Q A++LL
Sbjct: 158 DVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILL 217
Query: 352 FRGGNKELKNYNSQTPFQVAIIAGNFELAEYI 383
RG K L + N TP + + G E E +
Sbjct: 218 LRGA-KYLPDKNGVTPLDLCVQGGYGETCEVL 248
Score = 37.7 bits (86), Expect = 0.10
Identities = 26/85 (30%), Positives = 36/85 (42%)
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H A G V+ L LL GA+ + Q+ SG T LH+ A Q C LL + + N
Sbjct: 69 LHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICN 128
Query: 362 YNSQTPFQVAIIAGNFELAEYIKNH 386
T + G EL + H
Sbjct: 129 NEGLTAIHWLAVNGRTELLHDLVQH 153
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 84.3 bits (207), Expect = 1e-15
Identities = 68/232 (29%), Positives = 109/232 (46%), Gaps = 10/232 (4%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L D N D + +TPL +AA + + + +AL + L+ + G +ALH A +
Sbjct: 93 LLAHSADVNARD-KLWQTPLHVAAA-NRATKCAEALAPLLSSLNVADRSGRSALHHAVHS 150
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ + LL GAS + D PL+ A +G +LL+ A + CKD G+
Sbjct: 151 GHLETVNLLLNKGASLNVCDKKERQPLHWAAFLG-HLEVLKLLVARGADLGCKDRKGYGL 209
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H A G ++ +++LL GA++ NA GNTALHI QD+ A L+ G N N
Sbjct: 210 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPN 269
Query: 362 YNSQTPFQVAIIAGNFELAEYIKNHKETDIVPFREAPAYSNRRRRPPNTLAA 413
TP VA ++ N L + + D+ Y ++ + P +AA
Sbjct: 270 DKGFTPLHVAAVSTNGALCLELLVNNGADV-------NYQSKEGKSPLHMAA 314
Score = 77.0 bits (188), Expect = 2e-13
Identities = 53/200 (26%), Positives = 88/200 (44%), Gaps = 2/200 (1%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
+E + ++ RG D D + T AA +EV+K L GA +D G TAL
Sbjct: 186 LEVLKLLVARGADLGCKDRKGYGLLHTAAAS--GQIEVVKYLLRMGAEIDEPNAFGNTAL 243
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H A L+ GA+ + + G TPL+ A+ C ELL++ A V +
Sbjct: 244 HIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQS 303
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGG 355
+ G +H A +G + L+ G+++ + GNT LH+ A Y + L+ G
Sbjct: 304 KEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGA 363
Query: 356 NKELKNYNSQTPFQVAIIAG 375
+ + + P +A++ G
Sbjct: 364 DTARRGIHDMFPLHLAVLFG 383
Score = 71.2 bits (173), Expect = 9e-12
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 3/159 (1%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARN-QVALKTLLELGA 255
G T L +A L I+ L N GA+++ G T LH AA + N + L+ L+ GA
Sbjct: 239 GNTALHIACYLGQDAVAIE-LVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGA 297
Query: 256 SPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLE 315
+Y+ G +PL H A + G ++L+ + + C D+ G +H A RYGH +
Sbjct: 298 DVNYQSKEGKSPL-HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLIS 356
Query: 316 HLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRG 354
L+ GAD + + LH+ L+ C R LL G
Sbjct: 357 TLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSG 395
Score = 67.8 bits (164), Expect = 9e-11
Identities = 66/247 (26%), Positives = 102/247 (41%), Gaps = 27/247 (10%)
Query: 190 NFHDP-ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALK 248
N + P + G TPL +AA + ++ L N GA +++++K+G + LH AA +
Sbjct: 264 NVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQ 323
Query: 249 TLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQA--- 305
L++ G+ D D +G TPL H A G L+ A + + +H A
Sbjct: 324 ILIQNGSEIDCADKFGNTPL-HVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLF 382
Query: 306 -----CR--------YGHVQHL--EHLLFYGADMSAQNASGNTALHICALYNQDSCARVL 350
CR Y V L EH+L G D++ + G T LH A C +L
Sbjct: 383 GFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLL 442
Query: 351 LFRGGNKELKNYNSQTPFQVAIIAGNFELAEYI----KNHKETD---IVPFREAPAYSNR 403
L G + ++ +TP A G+++ A + E D P A A
Sbjct: 443 LSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTY 502
Query: 404 RRRPPNT 410
RR P+T
Sbjct: 503 RRAEPHT 509
Score = 62.0 bits (149), Expect = 5e-09
Identities = 62/244 (25%), Positives = 98/244 (40%), Gaps = 31/244 (12%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L G D N D G T L AA +VE + L + GA L R K G T LH AA
Sbjct: 409 VLSAGFDINTPD-NLGRTCLHAAAS-GGNVECLNLLLSSGADLRRRDKFGRTPLHYAAAN 466
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVG----GDP------------------- 278
+ TL+ GA + D G +PL++ A +P
Sbjct: 467 GSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRR 526
Query: 279 ----YCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLL--FYGADMSAQNASGN 332
+C E LL A +D G+ +H A YG+ Q+LE LL + ++
Sbjct: 527 KEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPV 586
Query: 333 TALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHKETDIV 392
+ LH+ A + L N +++++ +T +A G+ E E + H + ++
Sbjct: 587 SPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALI 646
Query: 393 PFRE 396
R+
Sbjct: 647 KERK 650
Score = 58.2 bits (139), Expect = 7e-08
Identities = 55/199 (27%), Positives = 86/199 (43%), Gaps = 7/199 (3%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHL-DFRAKDGMTALHKAAR 240
+LD G DP+ D + G T + AA + + L+ L D + ++ LH AA
Sbjct: 536 LLDNGADPSLRDRQ-GYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAY 594
Query: 241 ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD-ENGW 299
+ ALKTL E + D +D G T L+ A G C E+L A+ K+ + W
Sbjct: 595 NGHCEALKTLAETLVNLDVRDHKGRTALF-LATERGSTECVEVLTAHGASALIKERKRKW 653
Query: 300 HEIHQACRYGHVQHLEHLLFYG--ADMS-AQNASGNTALHICALYNQDSCARVLLFRGGN 356
+H A GH L L+ G AD++ +A G T L + + C +LL +G
Sbjct: 654 TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGST 713
Query: 357 KELKNYNSQTPFQVAIIAG 375
+ + +T + G
Sbjct: 714 ADAADLRGRTALHRGAVTG 732
Score = 56.2 bits (134), Expect = 3e-07
Identities = 55/199 (27%), Positives = 87/199 (43%), Gaps = 12/199 (6%)
Query: 197 GETPLTLAAQLDDS--VEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
G T L LA + + VEV+ A +G + L K T LH AA + + +L L++ G
Sbjct: 618 GRTALFLATERGSTECVEVLTA--HGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSG 675
Query: 255 ASPDYKD---SYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHV 311
D D +YG TPL AI+ G C LLL + +T D G +H+ G
Sbjct: 676 ERADITDVMDAYGQTPLM-LAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCE 734
Query: 312 QHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKEL----KNYNSQTP 367
L LL + A + ++ G T +H+ + + R LL + + +Y+ +P
Sbjct: 735 DCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSP 794
Query: 368 FQVAIIAGNFELAEYIKNH 386
A G+ + E + H
Sbjct: 795 MHWASYTGHEDCLELLLEH 813
Score = 54.3 bits (129), Expect = 1e-06
Identities = 52/220 (23%), Positives = 87/220 (39%), Gaps = 33/220 (15%)
Query: 196 TGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGA 255
T + PL A D VE +++L + +++ ++ T LH AA + L+ LL GA
Sbjct: 7 TDQPPLVQAIFSRD-VEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGA 65
Query: 256 SPDYKDSYGLTPLYHTAIVGGDPYCCELLLH--------------------EHATVCCK- 294
+ + KD+ LTPL+ A + LL H AT C +
Sbjct: 66 NVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEA 125
Query: 295 -----------DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQ 343
D +G +H A GH++ + LL GA ++ + LH A
Sbjct: 126 LAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGH 185
Query: 344 DSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYI 383
++L+ RG + K+ A +G E+ +Y+
Sbjct: 186 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYL 225
Score = 52.0 bits (123), Expect = 5e-06
Identities = 51/181 (28%), Positives = 73/181 (40%), Gaps = 4/181 (2%)
Query: 199 TPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPD 258
+PL LAA + E +K L +LD R G TAL A + ++ L GAS
Sbjct: 587 SPLHLAAY-NGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASAL 645
Query: 259 YKDSYGLTPLYHTAIVGGDPYCCELLLH--EHATVC-CKDENGWHEIHQACRYGHVQHLE 315
K+ H A G LL+ E A + D G + A GHV +
Sbjct: 646 IKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVH 705
Query: 316 HLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAG 375
LL G+ A + G TALH A+ + C LL +++ +TP +A G
Sbjct: 706 LLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACG 765
Query: 376 N 376
+
Sbjct: 766 H 766
Score = 48.9 bits (115), Expect = 5e-05
Identities = 51/191 (26%), Positives = 81/191 (42%), Gaps = 8/191 (4%)
Query: 212 EVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDS----YGLTP 267
+ + AL + A + R G T +H A+ + L+TLL+ S D D+ G +P
Sbjct: 735 DCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSP 794
Query: 268 LYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLL-FYGADM-S 325
+ H A G C ELLL EH+ + N + +H A E LL GA + +
Sbjct: 795 M-HWASYTGHEDCLELLL-EHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVN 852
Query: 326 AQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKN 385
+++A G T LH A + S R+LL ++ +T A G E++
Sbjct: 853 SRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLY 912
Query: 386 HKETDIVPFRE 396
+ D+ E
Sbjct: 913 RGKADLTVLDE 923
Score = 48.9 bits (115), Expect = 5e-05
Identities = 47/152 (30%), Positives = 62/152 (40%), Gaps = 5/152 (3%)
Query: 220 GGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPY 279
G ++ R G T LH AA A N L+ LL+ A + D G T L TA G
Sbjct: 847 GAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALM-TAAENGQTA 905
Query: 280 CCELLLHE-HATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNT---AL 335
E LL+ A + DEN +H AC GH + +L D+ NA+ + L
Sbjct: 906 AVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPL 965
Query: 336 HICALYNQDSCARVLLFRGGNKELKNYNSQTP 367
HI A S + LL G + TP
Sbjct: 966 HIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
Score = 46.6 bits (109), Expect = 2e-04
Identities = 39/151 (25%), Positives = 69/151 (45%), Gaps = 1/151 (0%)
Query: 235 LHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCK 294
L +A +R+ +++LL + + D TPL+ A VG P +LLL A V K
Sbjct: 12 LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPIL-QLLLMSGANVNAK 70
Query: 295 DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRG 354
D +H+A + + L LL + AD++A++ T LH+ A CA L
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
Query: 355 GNKELKNYNSQTPFQVAIIAGNFELAEYIKN 385
+ + + + ++ A+ +G+ E + N
Sbjct: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLN 161
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 84.0 bits (206), Expect = 1e-15
Identities = 107/404 (26%), Positives = 173/404 (42%), Gaps = 43/404 (10%)
Query: 105 QPASNGRDGKFLDEERLLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNL 164
+P N DG +D+ + E+ E + + +FR+++ V LD++ + T+ +L
Sbjct: 1795 KPLKNASDGALMDDNQ--NEWGD---EDLETKKFRFEEPVVLP-DLDDQTDHRQWTQQHL 1848
Query: 165 KKCMDHIQHRLVEKITKMLDRG-LDPNFHDPETGETPLTLAA------------QLDDSV 211
+ +D +D N P+ G TPL +A+ + +D+
Sbjct: 1849 DAADLRMSAMAPTPPQGEVDADCMDVNVRGPD-GFTPLMIASCSGGGLETGNSEEEEDAP 1907
Query: 212 EVIKALKNGGAHLDFRA-KDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYH 270
VI GA L + + G TALH AAR A K LLE A + +D+ G TPL H
Sbjct: 1908 AVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPL-H 1966
Query: 271 TAIVGGDPYCCELLLHEHAT-VCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNA 329
A+ ++L+ AT + + +G + A R LE L+ AD++A +
Sbjct: 1967 AAVSADAQGVFQILIRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDD 2026
Query: 330 SGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNH-KE 388
G +ALH A N A VLL G NK+++N +TP +A G++E A+ + +H
Sbjct: 2027 LGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNREETPLFLAAREGSYETAKVLLDHFAN 2086
Query: 389 TDIVPFREAPAYSNRRRRPPNTLAAPRV---LLRSNSDNNLNASAPDWAVCSTATSHRSL 445
DI ++ R P +A R+ ++R + NL S T +L
Sbjct: 2087 RDI---------TDHMDRLPRDIAQERMHHDIVRLLDEYNLVRSPQLHGAPLGGTP--TL 2135
Query: 446 SPQLLQQMPSKPEGAAKTIGSYVPGPRSRSPSLNRLGGAGEDGK 489
SP L P G ++ V G + R PS L ++ K
Sbjct: 2136 SPPL-----CSPNGYLGSLKPGVQGKKVRKPSSKGLACGSKEAK 2174
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 83.6 bits (205), Expect = 2e-15
Identities = 76/281 (27%), Positives = 123/281 (43%), Gaps = 7/281 (2%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L G D + D G+ A + + E+I AL + G LD + KDG TALH+A+
Sbjct: 61 LLKAGCDLDVQDD--GDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWH 118
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ K L++ GA+ K+ G T L H A +LL + K+ G
Sbjct: 119 GFSQSAKLLVKAGANVLAKNKAGNTAL-HLACQNSHSQSTRVLLLAGSRADLKNNAGDTC 177
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H A RY H+ + LL + +N +G+TALH+ A N A++LL G + + N
Sbjct: 178 LHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVN 237
Query: 362 YNSQTPFQVAIIAGNFELAEYIKNHKETDIVPFREAPAYSNRRRRPPNTLAAPRVLLRSN 421
QTP + A N E+A + K ++ F + +R R A V
Sbjct: 238 NAGQTPLETARYHNNPEVALLLT--KAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEV 295
Query: 422 SDNNLNASAPDWAVCSTATSHRSLSPQLLQQMPSKPEGAAK 462
+ + + SA D A + + + + + + + PE AK
Sbjct: 296 AQSKGSVSAGDTPSSEQAVARKEEARE--EFLSASPEPRAK 334
Score = 82.0 bits (201), Expect = 5e-15
Identities = 60/187 (32%), Positives = 87/187 (46%), Gaps = 2/187 (1%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G TPL LAA + V++ L G LD + TALH+A N + L+ G +
Sbjct: 42 GRTPLHLAAN-KGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCA 100
Query: 257 PDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEH 316
D +D G T L H A G +LL+ A V K++ G +H AC+ H Q
Sbjct: 101 LDRQDKDGNTAL-HEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRV 159
Query: 317 LLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGN 376
LL G+ +N +G+T LH+ A YN S R+LL + KN T VA +
Sbjct: 160 LLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNH 219
Query: 377 FELAEYI 383
++A+ +
Sbjct: 220 KKVAKIL 226
Score = 78.2 bits (191), Expect = 7e-14
Identities = 56/169 (33%), Positives = 81/169 (47%), Gaps = 2/169 (1%)
Query: 203 LAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDS 262
L A E + L N GA + K G T LH AA + ++ LL+ G D +D
Sbjct: 15 LVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDD 73
Query: 263 YGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGA 322
T L H A V G+ L+HE + +D++G +H+A +G Q + L+ GA
Sbjct: 74 GDQTAL-HRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
Query: 323 DMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVA 371
++ A+N +GNTALH+ + RVLL G +LKN T VA
Sbjct: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVA 181
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 82.8 bits (203), Expect = 3e-15
Identities = 69/218 (31%), Positives = 104/218 (47%), Gaps = 19/218 (8%)
Query: 186 GLDPNFHDPETGETPLTLAA--------------QLDD-SVEVIKALKNGGAHLDFRA-K 229
G+D N P+ G TPL LA+ + DD S +I L GA L R +
Sbjct: 1779 GMDVNVRGPD-GFTPLMLASFCGGALEPMPTEEDEADDTSASIISDLICQGAQLGARTDR 1837
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHA 289
G TALH AAR A K LL+ GA + +D G TPL HTA+ ++L+ +
Sbjct: 1838 TGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPL-HTAVTADAQGVFQILIRNRS 1896
Query: 290 T-VCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCAR 348
T + + +G + A R +E L+ AD++A + G +ALH A N
Sbjct: 1897 TDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATL 1956
Query: 349 VLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
LL G NK++++ +TP +A G++E A+ + +H
Sbjct: 1957 ALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDH 1994
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 82.4 bits (202), Expect = 4e-15
Identities = 56/154 (36%), Positives = 77/154 (50%), Gaps = 2/154 (1%)
Query: 231 GMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHAT 290
G T LH AAR A + LLE GA+P+ D G TPL H A+ C+LLL T
Sbjct: 1634 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPL-HAAVAADAREVCQLLLRSRQT 1692
Query: 291 -VCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARV 349
V + E+G + A R +E L+ AD+ A++ G TALH A N AR
Sbjct: 1693 AVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARS 1752
Query: 350 LLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYI 383
LL G +K+ ++ QTP +A G E+A+ +
Sbjct: 1753 LLQAGADKDAQDNREQTPLFLAAREGAVEVAQLL 1786
Score = 66.6 bits (161), Expect = 2e-10
Identities = 67/231 (29%), Positives = 100/231 (43%), Gaps = 13/231 (5%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+LD G P H TGETPL LAA+ + L+ GA+ + + G T LH A A
Sbjct: 1619 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLE-AGANPNQPDRAGRTPLHAAVAA 1677
Query: 242 RNQVALKTLLELGASP-DYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWH 300
+ + LL + D + G TPL A + + EL+ + A V +D+ G
Sbjct: 1678 DAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQ-ADVGARDKWGKT 1736
Query: 301 EIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELK 360
+H A + + LL GAD AQ+ T L + A A++LL G +EL+
Sbjct: 1737 ALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELR 1796
Query: 361 NYNSQTPFQVAIIAGNFELAEYIK-------NHKETDIVPFREAPAYSNRR 404
+ P VA +++L ++ HK T P REA + R
Sbjct: 1797 DQAGLAPADVAHQRNHWDLLTLLEGAGPPEARHKAT---PGREAGPFPRAR 1844
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 80.9 bits (198), Expect = 1e-14
Identities = 69/245 (28%), Positives = 110/245 (44%), Gaps = 11/245 (4%)
Query: 128 PVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGL 187
P+G G +LE K + Q S K+L + + ++ ++ ++K+ ML L
Sbjct: 590 PLGPGREALE----KALVIQESERRKKL-----RFHPRQLYLSVKQGELQKVILMLLDNL 640
Query: 188 DPNFH-DPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVA 246
DPNF D ++ TPL AAQ SVE+ L GA+++ K T L +A +
Sbjct: 641 DPNFQSDQQSKRTPLHAAAQ-KGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEV 699
Query: 247 LKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQAC 306
+ +++ G K+ G T L+H A +G LL V +D GW I A
Sbjct: 700 ARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAA 759
Query: 307 RYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQT 366
+ H++ + LL GAD++ + N LH + + A VLL + NY+ T
Sbjct: 760 EHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDT 819
Query: 367 PFQVA 371
P +A
Sbjct: 820 PLHIA 824
Score = 35.0 bits (79), Expect = 0.68
Identities = 24/90 (26%), Positives = 40/90 (44%)
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H A + G V+ LL GA+++A + T L + N AR ++ RGG K
Sbjct: 655 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 714
Query: 362 YNSQTPFQVAIIAGNFELAEYIKNHKETDI 391
+ T A GN E+ + + + D+
Sbjct: 715 EDGSTCLHHAAKIGNLEMVSLLLSTGQVDV 744
Score = 32.3 bits (72), Expect = 4.4
Identities = 21/85 (24%), Positives = 38/85 (44%), Gaps = 2/85 (2%)
Query: 301 EIHQACRYGHVQHLEHLLFYGADMSAQN--ASGNTALHICALYNQDSCARVLLFRGGNKE 358
+++ + + G +Q + +L D + Q+ S T LH A VLL G N
Sbjct: 619 QLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 678
Query: 359 LKNYNSQTPFQVAIIAGNFELAEYI 383
+ +TP A++ + E+A Y+
Sbjct: 679 AVDKQQRTPLMEAVVNNHLEVARYM 703
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 80.9 bits (198), Expect = 1e-14
Identities = 69/245 (28%), Positives = 110/245 (44%), Gaps = 11/245 (4%)
Query: 128 PVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGL 187
P+G G +LE K + Q S K+L + + ++ ++ ++K+ ML L
Sbjct: 624 PLGPGREALE----KALVIQESERRKKL-----RFHPRQLYLSVKQGELQKVILMLLDNL 674
Query: 188 DPNFH-DPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVA 246
DPNF D ++ TPL AAQ SVE+ L GA+++ K T L +A +
Sbjct: 675 DPNFQSDQQSKRTPLHAAAQ-KGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEV 733
Query: 247 LKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQAC 306
+ +++ G K+ G T L+H A +G LL V +D GW I A
Sbjct: 734 ARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAA 793
Query: 307 RYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQT 366
+ H++ + LL GAD++ + N LH + + A VLL + NY+ T
Sbjct: 794 EHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDT 853
Query: 367 PFQVA 371
P +A
Sbjct: 854 PLHIA 858
Score = 35.0 bits (79), Expect = 0.68
Identities = 24/90 (26%), Positives = 40/90 (44%)
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H A + G V+ LL GA+++A + T L + N AR ++ RGG K
Sbjct: 689 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 748
Query: 362 YNSQTPFQVAIIAGNFELAEYIKNHKETDI 391
+ T A GN E+ + + + D+
Sbjct: 749 EDGSTCLHHAAKIGNLEMVSLLLSTGQVDV 778
Score = 32.3 bits (72), Expect = 4.4
Identities = 21/85 (24%), Positives = 38/85 (44%), Gaps = 2/85 (2%)
Query: 301 EIHQACRYGHVQHLEHLLFYGADMSAQN--ASGNTALHICALYNQDSCARVLLFRGGNKE 358
+++ + + G +Q + +L D + Q+ S T LH A VLL G N
Sbjct: 653 QLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANIN 712
Query: 359 LKNYNSQTPFQVAIIAGNFELAEYI 383
+ +TP A++ + E+A Y+
Sbjct: 713 AVDKQQRTPLMEAVVNNHLEVARYM 737
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 80.1 bits (196), Expect = 2e-14
Identities = 62/240 (25%), Positives = 103/240 (42%), Gaps = 34/240 (14%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
V+ + +L+ G D + H G TPL AA + + V+ L GA +D +G T L
Sbjct: 761 VDVVDLLLEGGADVD-HTDNNGRTPLLAAASMGHA-SVVNTLLFWGAAVDSIDSEGRTVL 818
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVG-------------------- 275
A+ N ++TLL+ G +++D G TPL+ A G
Sbjct: 819 SIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDN 878
Query: 276 ------------GDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGAD 323
G C ++LL + + + +G + + A GH +E L +GAD
Sbjct: 879 DGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGAD 938
Query: 324 MSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYI 383
++ ++A G L+I AL NQ + A L G N E + +T V+ G+ E+ + +
Sbjct: 939 VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
Score = 78.2 bits (191), Expect = 7e-14
Identities = 59/208 (28%), Positives = 97/208 (46%), Gaps = 3/208 (1%)
Query: 179 ITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKA 238
++ ++DRG + + H + G TPL +AA + V+V+ L GGA +D +G T L A
Sbjct: 731 VSLLIDRGAEVD-HCDKDGMTPLLVAAY-EGHVDVVDLLLEGGADVDHTDNNGRTPLLAA 788
Query: 239 ARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENG 298
A + + TLL GA+ D DS G T L A G+ LL +D+ G
Sbjct: 789 ASMGHASVVNTLLFWGAAVDSIDSEGRTVL-SIASAQGNVEVVRTLLDRGLDENHRDDAG 847
Query: 299 WHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKE 358
W +H A GH E L+ GA + + G + + C ++LL N +
Sbjct: 848 WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNID 907
Query: 359 LKNYNSQTPFQVAIIAGNFELAEYIKNH 386
+ Y+ + +VA + G+ ++ E + +H
Sbjct: 908 QRGYDGRNALRVAALEGHRDIVELLFSH 935
Score = 73.2 bits (178), Expect = 2e-12
Identities = 62/208 (29%), Positives = 94/208 (45%), Gaps = 8/208 (3%)
Query: 179 ITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKA 238
+ +L G + N D E G T L AA + E+++ L + GA ++ DG TAL A
Sbjct: 660 VLNLLQHGAEVNKADNE-GRTALIAAAYMGHR-EIVEHLLDHGAEVNHEDVDGRTALSVA 717
Query: 239 ARA-----RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCC 293
A + + L++ GA D+ D G+TPL A G +LLL A V
Sbjct: 718 ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLL-VAAYEGHVDVVDLLLEGGADVDH 776
Query: 294 KDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFR 353
D NG + A GH + LLF+GA + + ++ G T L I + R LL R
Sbjct: 777 TDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDR 836
Query: 354 GGNKELKNYNSQTPFQVAIIAGNFELAE 381
G ++ ++ TP +A G+ + E
Sbjct: 837 GLDENHRDDAGWTPLHMAAFEGHRLICE 864
Score = 71.6 bits (174), Expect = 7e-12
Identities = 64/222 (28%), Positives = 102/222 (45%), Gaps = 8/222 (3%)
Query: 170 HIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDS----VEVIKALKNGGAHLD 225
++ HR E + +LD G + N H+ G T L++AA + V+ L + GA +D
Sbjct: 686 YMGHR--EIVEHLLDHGAEVN-HEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVD 742
Query: 226 FRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLL 285
KDGMT L AA + + LLE GA D+ D+ G TPL A +G LL
Sbjct: 743 HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMG-HASVVNTLL 801
Query: 286 HEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDS 345
A V D G + A G+V+ + LL G D + ++ +G T LH+ A
Sbjct: 802 FWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRL 861
Query: 346 CARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHK 387
L+ +G + + + PF +A G+++ + + +K
Sbjct: 862 ICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENK 903
Score = 67.0 bits (162), Expect = 2e-10
Identities = 57/211 (27%), Positives = 94/211 (44%), Gaps = 3/211 (1%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
VE + +LDRGLD N D + G TPL +AA + + +AL GA + DG
Sbjct: 827 VEVVRTLLDRGLDENHRD-DAGWTPLHMAA-FEGHRLICEALIEQGARTNEIDNDGRIPF 884
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
A++ + ++ LLE ++ D + G L A + G ELL A V CKD
Sbjct: 885 ILASQEGHYDCVQILLENKSNIDQRGYDGRNAL-RVAALEGHRDIVELLFSHGADVNCKD 943
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGG 355
+G ++ + E+ L GA++ A +A G TALH+ +VL+
Sbjct: 944 ADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHA 1003
Query: 356 NKELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
+ + ++ Q A G+ ++ + + H
Sbjct: 1004 DVNAADNEKRSALQSAAWQGHVKVVQLLIEH 1034
Score = 63.2 bits (152), Expect = 2e-09
Identities = 56/197 (28%), Positives = 85/197 (43%), Gaps = 3/197 (1%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
+ I +LD G N D G T L AA S++V+ L + GA L+ G T L
Sbjct: 526 DSIRTLLDNGASVNQCD-SNGRTLLANAAY-SGSLDVVNLLVSRGADLEIEDAHGHTPLT 583
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
AAR + + L+ GA+ ++ D G T L +A GG LL+ V C D
Sbjct: 584 LAARQGHTKVVNCLIGCGANINHTDQDGWTAL-RSAAWGGHTEVVSALLYAGVKVDCADA 642
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
+ + A GH + +LL +GA+++ + G TAL A LL G
Sbjct: 643 DSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAE 702
Query: 357 KELKNYNSQTPFQVAII 373
++ + +T VA +
Sbjct: 703 VNHEDVDGRTALSVAAL 719
Score = 60.1 bits (144), Expect = 2e-08
Identities = 50/210 (23%), Positives = 87/210 (41%), Gaps = 5/210 (2%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
E + ++ G N D T + Q + + I+ L + GA ++ +G T L
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTS----CIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLA 550
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
AA + + + L+ GA + +D++G TPL A G L+ A + D+
Sbjct: 551 NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLT-LAARQGHTKVVNCLIGCGANINHTDQ 609
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
+GW + A GH + + LL+ G + +A TAL A + LL G
Sbjct: 610 DGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAE 669
Query: 357 KELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
+ +T A G+ E+ E++ +H
Sbjct: 670 VNKADNEGRTALIAAAYMGHREIVEHLLDH 699
Score = 59.7 bits (143), Expect = 3e-08
Identities = 59/253 (23%), Positives = 114/253 (45%), Gaps = 13/253 (5%)
Query: 175 LVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTA 234
L+E + + RG D G L +AA L+ ++++ L + GA ++ + DG
Sbjct: 899 LLENKSNIDQRGYD--------GRNALRVAA-LEGHRDIVELLFSHGADVNCKDADGRPT 949
Query: 235 LHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCK 294
L+ A + LE GA+ + D+ G T L H + G ++L+ HA V
Sbjct: 950 LYILALENQLTMAEYFLENGANVEASDAEGRTAL-HVSCWQGHMEMVQVLIAYHADVNAA 1008
Query: 295 DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRG 354
D + A GHV+ ++ L+ +GA + G TAL I A +VLL G
Sbjct: 1009 DNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG 1068
Query: 355 GNKELKNYNSQTPFQVAIIAGNFELAEYIKNHKETDIVPFREAPAYSNRRRRPPNTLAA- 413
+ + +T +VA G+ ++ + ++ + + + +P ++ ++P +L++
Sbjct: 1069 ADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHT-MEQKPLQSLSSK 1127
Query: 414 -PRVLLRSNSDNN 425
+ ++SNS +
Sbjct: 1128 VQSLTIKSNSSGS 1140
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 79.3 bits (194), Expect = 3e-14
Identities = 63/218 (28%), Positives = 101/218 (46%), Gaps = 5/218 (2%)
Query: 156 AKLHTKTNLKKCMDH--IQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEV 213
A+++ K N+ H + R E + ++ D N D + +TPL +AA + +V+
Sbjct: 40 ARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARD-KNWQTPLHVAAA-NKAVKC 97
Query: 214 IKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAI 273
+ + + ++ + G TALH AA + + LL GA+ + D L+ A
Sbjct: 98 AEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAY 157
Query: 274 VGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNT 333
+G LL++ A V CKD+ G+ +H A G + ++HLL G ++ N GNT
Sbjct: 158 MGHLDVVA-LLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNT 216
Query: 334 ALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVA 371
ALHI QD+ L+ G N N N TP A
Sbjct: 217 ALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFA 254
Score = 78.2 bits (191), Expect = 7e-14
Identities = 57/198 (28%), Positives = 94/198 (47%), Gaps = 3/198 (1%)
Query: 188 DPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVAL 247
D N D E TPL +AA L D+ E+I+ L GA ++ + +T LH+A +R++ A+
Sbjct: 8 DVNTLDSEK-RTPLHVAAFLGDA-EIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAV 65
Query: 248 KTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACR 307
+ L++ A + +D TPL H A C E+++ ++V D G +H A
Sbjct: 66 QVLIKHSADVNARDKNWQTPL-HVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAAL 124
Query: 308 YGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTP 367
GHV+ + LL GA+++A + ALH A +L+ G K+ TP
Sbjct: 125 NGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTP 184
Query: 368 FQVAIIAGNFELAEYIKN 385
A G + +++ N
Sbjct: 185 LHAAASNGQINVVKHLLN 202
Score = 75.9 bits (185), Expect = 3e-13
Identities = 51/198 (25%), Positives = 89/198 (44%), Gaps = 2/198 (1%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
++ + +++ G + D + G TPL AA + + V+K L N G +D G TAL
Sbjct: 161 LDVVALLINHGAEVTCKDKK-GYTPLHAAAS-NGQINVVKHLLNLGVEIDEINVYGNTAL 218
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H A + L++ GA+ + ++ G TPL+ A C ELL++ A V +
Sbjct: 219 HIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQS 278
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGG 355
++G +H +G + L+ G ++ + GNT LH+ A Y + L G
Sbjct: 279 KDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGA 338
Query: 356 NKELKNYNSQTPFQVAII 373
+ +S P +A +
Sbjct: 339 DTAKCGIHSMFPLHLAAL 356
Score = 70.9 bits (172), Expect = 1e-11
Identities = 66/234 (28%), Positives = 99/234 (42%), Gaps = 31/234 (13%)
Query: 181 KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAAR 240
K+L G + + D + G T L AA +VE IK L++ GA + K G T LH AA
Sbjct: 365 KLLSSGFEIDTPD-KFGRTCLHAAAA-GGNVECIKLLQSSGADFHKKDKCGRTPLHYAAA 422
Query: 241 ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGD----------------------- 277
+ ++TL+ GA+ + D +G T L++ A D
Sbjct: 423 NCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELK 482
Query: 278 ----PYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNT 333
C E LL A +D+ G++ IH A YGH Q LE LL ++ SG T
Sbjct: 483 EKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGAT 542
Query: 334 --ALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKN 385
LH+ A VLL + ++++ +T +A G+ E E + N
Sbjct: 543 KSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALIN 596
Score = 67.0 bits (162), Expect = 2e-10
Identities = 51/175 (29%), Positives = 78/175 (44%), Gaps = 3/175 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+++ G D N + G++PL + A ++NGG +D KDG T LH AAR
Sbjct: 267 LVNNGADVNIQSKD-GKSPLHMTAVHGRFTRSQTLIQNGG-EIDCVDKDGNTPLHVAARY 324
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+++ + TL GA + + PL H A + CC LL + D+ G
Sbjct: 325 GHELLINTLRTSGADTAKCGIHSMFPL-HLAALNAHSDCCRKLLSSGFEIDTPDKFGRTC 383
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
+H A G+V+ ++ L GAD ++ G T LH A C L+ G N
Sbjct: 384 LHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGAN 438
Score = 67.0 bits (162), Expect = 2e-10
Identities = 74/278 (26%), Positives = 112/278 (40%), Gaps = 49/278 (17%)
Query: 160 TKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKN 219
TK+ L + H+ +E + + L +D + D E G T L LAA E ++AL N
Sbjct: 542 TKSPLHLAAYNGHHQALEVLLQSL---VDLDIRD-EKGRTALDLAA-FKGHTECVEALIN 596
Query: 220 GGAHLDFRAKDGMTA---LHKAARARNQVALKTLLELGASP---DYKDSYGLTPLY---- 269
GA + KD +T LH + + + L+ LLE+ +P D KD+ G TPL
Sbjct: 597 PGASIF--VKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVA 654
Query: 270 ----------------------------HTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
H I+ G C ++LL + ++ CKD G
Sbjct: 655 YGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTP 714
Query: 302 IHQACRYGHVQHLEHLL---FYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKE 358
+H A GH L LL D ++ G T LH ++C VLL + ++
Sbjct: 715 LHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRK 774
Query: 359 LKNYNSQTPFQVAIIAGNFELAEYIKNHKETDIVPFRE 396
N TP AII + A + ++ IV R+
Sbjct: 775 FIG-NPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRD 811
Score = 65.5 bits (158), Expect = 5e-10
Identities = 54/191 (28%), Positives = 85/191 (44%), Gaps = 6/191 (3%)
Query: 191 FHDPETGET--PLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALK 248
F + ++G T PL LAA + + ++ L LD R + G TAL AA + ++
Sbjct: 534 FEESDSGATKSPLHLAAY-NGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVE 592
Query: 249 TLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLH---EHATVCCKDENGWHEIHQA 305
L+ GAS KD+ H +++ G C LLL V KD G + A
Sbjct: 593 ALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLA 652
Query: 306 CRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQ 365
YGH+ + LL A++ + G TALH + + C ++LL + + K+ +
Sbjct: 653 VAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGR 712
Query: 366 TPFQVAIIAGN 376
TP A G+
Sbjct: 713 TPLHYAAARGH 723
Score = 65.1 bits (157), Expect = 6e-10
Identities = 56/196 (28%), Positives = 86/196 (43%), Gaps = 10/196 (5%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G+TPL LA ++ + L A++D G TALH+ ++ ++ LLE S
Sbjct: 645 GQTPLMLAVAYGH-IDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVS 703
Query: 257 PDYKDSYGLTPLYHTAIVGGDPYCCELL--LHEHATVCCKDENGWHEIHQACRYGHVQHL 314
KDS G TPL++ A G + ELL C KD G+ +H AC G+ +
Sbjct: 704 ILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCI 763
Query: 315 EHLLFYGADMSAQNASGN--TALHICALYNQDSCARVLL--FRGGNKELKNYNSQTPFQV 370
E LL + GN T LH + + +CA +LL ++ +TP +
Sbjct: 764 EVLL---EQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRA 820
Query: 371 AIIAGNFELAEYIKNH 386
A A + E + + H
Sbjct: 821 AAFADHVECLQLLLRH 836
Score = 64.7 bits (156), Expect = 8e-10
Identities = 59/219 (26%), Positives = 87/219 (39%), Gaps = 12/219 (5%)
Query: 179 ITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKA 238
+ +++D G + N G TPL AA ++ L N GA ++ ++KDG + LH
Sbjct: 230 VNELIDYGANVN-QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMT 288
Query: 239 ARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENG 298
A +TL++ G D D G TPL+ A G + L T C G
Sbjct: 289 AVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKC----G 344
Query: 299 WHE---IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGG 355
H +H A H LL G ++ + G T LH A C ++L G
Sbjct: 345 IHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGA 404
Query: 356 NKELKNYNSQTPFQVAIIAGNFELAEYI----KNHKETD 390
+ K+ +TP A +F E + N ETD
Sbjct: 405 DFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETD 443
Score = 62.0 bits (149), Expect = 5e-09
Identities = 49/154 (31%), Positives = 69/154 (44%), Gaps = 2/154 (1%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G TPL +AA+ + +I L+ GA M LH AA + + LL G
Sbjct: 314 GNTPLHVAARYGHEL-LINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFE 372
Query: 257 PDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEH 316
D D +G T L H A GG+ C +LL A KD+ G +H A H +E
Sbjct: 373 IDTPDKFGRTCL-HAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIET 431
Query: 317 LLFYGADMSAQNASGNTALHICALYNQDSCARVL 350
L+ GA+++ + G TALH A + D +L
Sbjct: 432 LVTTGANVNETDDWGRTALHYAAASDMDRNKTIL 465
Score = 58.5 bits (140), Expect = 6e-08
Identities = 49/171 (28%), Positives = 77/171 (45%), Gaps = 7/171 (4%)
Query: 214 IKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLT--PLYHT 271
++ L A+ R K+G ++H AA ++ L+ LLE S + G T PL H
Sbjct: 490 LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPL-HL 548
Query: 272 AIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQ-NAS 330
A G E+LL + +DE G + A GH + +E L+ GA + + N +
Sbjct: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608
Query: 331 GNTALHICALYNQDSCARVLLFRGGNKE---LKNYNSQTPFQVAIIAGNFE 378
T LH + C R+LL N E +K+ QTP +A+ G+ +
Sbjct: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHID 659
Score = 57.4 bits (137), Expect = 1e-07
Identities = 54/189 (28%), Positives = 87/189 (46%), Gaps = 7/189 (3%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLD--FRAKDGMTALHKAARARNQVALKTLLELG 254
G TPL AA + + + L+ + D F+ G T LH A N+ ++ LLE
Sbjct: 711 GRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQK 770
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLH--EHATVCCKDENGWHEIHQACRYGHVQ 312
+ + TPL H AI+ C LLL + + V C+D+ G + A HV+
Sbjct: 771 CFRKFIGN-PFTPL-HCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVE 828
Query: 313 HLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRG-GNKELKNYNSQTPFQVA 371
L+ LL + A ++A + SG TAL + A Q +L+ + +K+ + TP +A
Sbjct: 829 CLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLA 888
Query: 372 IIAGNFELA 380
G+ + A
Sbjct: 889 CSKGHEKCA 897
Score = 54.3 bits (129), Expect = 1e-06
Identities = 40/154 (25%), Positives = 68/154 (44%), Gaps = 1/154 (0%)
Query: 233 TALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVC 292
T LH AA + ++ L+ GA + KD+ LTPL H A+ ++L+ A V
Sbjct: 18 TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPL-HRAVASRSEEAVQVLIKHSADVN 76
Query: 293 CKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLF 352
+D+N +H A V+ E ++ + ++ + G TALH AL +LL
Sbjct: 77 ARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLA 136
Query: 353 RGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
+G N + + A G+ ++ + NH
Sbjct: 137 KGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170
Score = 38.1 bits (87), Expect = 0.080
Identities = 26/101 (25%), Positives = 44/101 (43%)
Query: 283 LLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYN 342
+L+H+ V D +H A G + +E L+ GA ++A++ T LH
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 343 QDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYI 383
+ +VL+ + ++ N QTP VA + AE I
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVI 101
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 78.6 bits (192), Expect = 5e-14
Identities = 58/197 (29%), Positives = 90/197 (45%), Gaps = 6/197 (3%)
Query: 181 KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKD--GMTALHKA 238
K ++R L HD +T + DD +++ N + + ++D G T LH A
Sbjct: 411 KEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVA 470
Query: 239 ARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENG 298
A + L+ GA + D +G TPL H A G LLLH A+ +D NG
Sbjct: 471 AVCGQASLIDLLVSKGAMVNATDYHGATPL-HLACQKGYQSVTLLLLHYKASAEVQDNNG 529
Query: 299 WHEIHQACRYGHVQHLEHLLFYGAD---MSAQNASGNTALHICALYNQDSCARVLLFRGG 355
+H AC YGH ++ L++Y + + N G+T LHI A + LL G
Sbjct: 530 NTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGA 589
Query: 356 NKELKNYNSQTPFQVAI 372
+ E++N +TP + A+
Sbjct: 590 STEIQNRLKETPLKCAL 606
Score = 62.4 bits (150), Expect = 4e-09
Identities = 53/166 (31%), Positives = 78/166 (46%), Gaps = 4/166 (2%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
+++ K+ GL N + G +PL +AA L ++I L GA+ R D LH
Sbjct: 725 KRLAKVPASGLGVNVTSQD-GSSPLHVAA-LHGRADLIPLLLKHGANAGARNADQAVPLH 782
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
A + + +K LL+ A P+ KD G TPL + A GG LLL A++ +
Sbjct: 783 LACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIY-ACSGGHHELVALLLQHGASINASNN 841
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYN 342
G +H+A HV +E LL +GA + N TA+ CA N
Sbjct: 842 KGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVD-CAEQN 886
Score = 60.8 bits (146), Expect = 1e-08
Identities = 42/140 (30%), Positives = 65/140 (46%), Gaps = 5/140 (3%)
Query: 256 SPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLE 315
+P +D G TPL H A V G +LL+ + A V D +G +H AC+ G+
Sbjct: 455 TPFSRDDRGHTPL-HVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTL 513
Query: 316 HLLFYGADMSAQNASGNTALHICALYNQDSCARVLLF---RGGNKELKNYNSQTPFQVAI 372
LL Y A Q+ +GNT LH+ Y + C + L++ ++ N TP +A
Sbjct: 514 LLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAA 573
Query: 373 IAGNFELAE-YIKNHKETDI 391
G + E ++N T+I
Sbjct: 574 RWGYQGVIETLLQNGASTEI 593
Score = 45.1 bits (105), Expect = 7e-04
Identities = 40/150 (26%), Positives = 63/150 (42%), Gaps = 3/150 (2%)
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
K A A+ ++A LG + +D G +PL H A + G LLL A ++
Sbjct: 719 KCAPAQKRLAKVPASGLGVNVTSQD--GSSPL-HVAALHGRADLIPLLLKHGANAGARNA 775
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
+ +H AC+ GH Q ++ LL A + ++ SGNT L +LL G +
Sbjct: 776 DQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGAS 835
Query: 357 KELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
N T A+I + + E + H
Sbjct: 836 INASNNKGNTALHEAVIEKHVFVVELLLLH 865
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 77.0 bits (188), Expect = 2e-13
Identities = 71/292 (24%), Positives = 132/292 (45%), Gaps = 20/292 (6%)
Query: 149 SLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLD 208
++D++ L + T L C H+ + + +L G +P+ + ++ ETPL A +
Sbjct: 116 TIDQRTLQE-ETAVYLATCRGHL-----DCLLSLLQAGAEPDISN-KSRETPLYKACERK 168
Query: 209 DSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPL 268
++ E +K L A + R G TALH++ + ++ L+ GA + K++YG+TPL
Sbjct: 169 NA-EAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPL 227
Query: 269 YHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQN 328
+ A G L A + + + +++AC+ H + +E LL GAD + N
Sbjct: 228 F-VAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTN 286
Query: 329 ASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNHK- 387
G LHI + ++LL ++ + +P +A + E+ E + + +
Sbjct: 287 KDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRR-SGVSPLHLAAERNHDEVLEALLSARF 345
Query: 388 --ETDIVPFREAPAYSNRRRRP------PNTLAAPRVLLRSNSDNNLNASAP 431
T + P R A Y +RR N + A +LL+ +D N + +P
Sbjct: 346 DVNTPLAPER-ARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISP 396
Score = 45.1 bits (105), Expect = 7e-04
Identities = 48/182 (26%), Positives = 75/182 (41%), Gaps = 6/182 (3%)
Query: 208 DDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGL-- 265
D E +K + G +L K+G LH+AA LK L A P D L
Sbjct: 67 DGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQR--AYPGTIDQRTLQE 124
Query: 266 -TPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADM 324
T +Y A G C LL A +++ +++AC + + ++ L+ + AD
Sbjct: 125 ETAVY-LATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADT 183
Query: 325 SAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIK 384
+ + G TALH N ++L+ G E KN TP VA +G E ++
Sbjct: 184 NHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLA 243
Query: 385 NH 386
+
Sbjct: 244 KY 245
Score = 42.7 bits (99), Expect = 0.003
Identities = 28/116 (24%), Positives = 48/116 (41%), Gaps = 1/116 (0%)
Query: 272 AIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHL-LFYGADMSAQNAS 330
AI GD + ++ E + ++ GW +H+A YG V L+ L Y + +
Sbjct: 64 AIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQ 123
Query: 331 GNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAEYIKNH 386
TA+++ C LL G ++ N + +TP A N E + + H
Sbjct: 124 EETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
Score = 38.9 bits (89), Expect = 0.047
Identities = 41/162 (25%), Positives = 68/162 (41%), Gaps = 12/162 (7%)
Query: 304 QACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVL-LFRGGNKELKNY 362
+A + G + L+ ++ G +++ N G LH A Y Q C +VL G + +
Sbjct: 63 KAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTL 122
Query: 363 NSQTPFQVAIIAGNFE-LAEYIKNHKETDIV-PFREAPAYSNRRRRPPNTLAAPRVLLRS 420
+T +A G+ + L ++ E DI RE P Y R+ A ++L++
Sbjct: 123 QEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERK---NAEAVKILVQH 179
Query: 421 NSDNNLNASAPDWAVCSTATSHRSLSPQLLQQMPSKPEGAAK 462
N+D N + W H S+S L+ M G AK
Sbjct: 180 NADTNHRCNR-GWTAL-----HESVSRNDLEVMQILVSGGAK 215
Score = 32.0 bits (71), Expect = 5.7
Identities = 43/184 (23%), Positives = 81/184 (44%), Gaps = 15/184 (8%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
E + +L +G D N + + G PL +A++ + +++ L + R + G++ LH
Sbjct: 270 EVVEFLLSQGADANKTNKD-GLLPLHIASK-KGNYRIVQMLLPVTSRTRIR-RSGVSPLH 326
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLY--------HTAIVGGDPYCCELLLHEH 288
AA + L+ LL + + LY + A+V + Y ELLL
Sbjct: 327 LAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHG 386
Query: 289 ATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCAR 348
A + + + A R+G ++ ++ LL +GA++ A A+ TA ++ C
Sbjct: 387 AD---PNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAM-KCLS 442
Query: 349 VLLF 352
+L F
Sbjct: 443 LLKF 446
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,380,722
Number of Sequences: 37866
Number of extensions: 4946605
Number of successful extensions: 44924
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 619
Number of HSP's successfully gapped in prelim test: 1031
Number of HSP's that attempted gapping in prelim test: 26418
Number of HSP's gapped (non-prelim): 14840
length of query: 1849
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1732
effective length of database: 13,817,196
effective search space: 23931383472
effective search space used: 23931383472
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.