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Search of human proteins with 226528772
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|226528772 coiled-coil domain containing 81 isoform 2 [Homo
sapiens]
(562 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|226528772 coiled-coil domain containing 81 isoform 2 [Homo sa... 1118 0.0
gi|226493512 coiled-coil domain containing 81 isoform 1 [Homo sa... 935 0.0
gi|148746195 trichohyalin [Homo sapiens] 70 5e-12
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 52 1e-06
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 52 1e-06
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 52 1e-06
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 52 1e-06
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 52 1e-06
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 52 1e-06
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 52 1e-06
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 52 1e-06
gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens] 52 1e-06
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 52 2e-06
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 52 2e-06
gi|31982906 cingulin-like 1 [Homo sapiens] 51 2e-06
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 51 3e-06
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 51 3e-06
gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 51 3e-06
gi|221139761 zinc finger protein 853 [Homo sapiens] 50 5e-06
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 50 5e-06
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 50 7e-06
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 50 7e-06
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 49 1e-05
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 49 1e-05
gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens] 49 1e-05
gi|14165274 golgi-associated microtubule-binding protein HOOK3 [... 49 1e-05
gi|110347568 centrosomal protein 152kDa [Homo sapiens] 48 2e-05
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 48 3e-05
gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens] 47 6e-05
gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo... 47 6e-05
>gi|226528772 coiled-coil domain containing 81 isoform 2 [Homo
sapiens]
Length = 562
Score = 1118 bits (2892), Expect = 0.0
Identities = 562/562 (100%), Positives = 562/562 (100%)
Query: 1 MLDTIARALQDLGRQVLPTLPSLSQEEVSIIWGNVSEFVRRQLTLHKGVQIPAFGTFTFI 60
MLDTIARALQDLGRQVLPTLPSLSQEEVSIIWGNVSEFVRRQLTLHKGVQIPAFGTFTFI
Sbjct: 1 MLDTIARALQDLGRQVLPTLPSLSQEEVSIIWGNVSEFVRRQLTLHKGVQIPAFGTFTFI 60
Query: 61 RQKLEVGNNKFILIQRPVFIMVEKLVQIHGLKQNKRPGTVDSVLSSREALRKWPSSVLAF 120
RQKLEVGNNKFILIQRPVFIMVEKLVQIHGLKQNKRPGTVDSVLSSREALRKWPSSVLAF
Sbjct: 61 RQKLEVGNNKFILIQRPVFIMVEKLVQIHGLKQNKRPGTVDSVLSSREALRKWPSSVLAF 120
Query: 121 PRIELKEMENKLPMETLVEECGENRERKCKLKDQSDKEEGTRDISSPKRLRDRQALFPAK 180
PRIELKEMENKLPMETLVEECGENRERKCKLKDQSDKEEGTRDISSPKRLRDRQALFPAK
Sbjct: 121 PRIELKEMENKLPMETLVEECGENRERKCKLKDQSDKEEGTRDISSPKRLRDRQALFPAK 180
Query: 181 VTNVSLLEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTSPACQDHNKAGQEMCYVCL 240
VTNVSLLEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTSPACQDHNKAGQEMCYVCL
Sbjct: 181 VTNVSLLEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTSPACQDHNKAGQEMCYVCL 240
Query: 241 QRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNLG 300
QRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNLG
Sbjct: 241 QRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNLG 300
Query: 301 VAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQYR 360
VAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQYR
Sbjct: 301 VAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQYR 360
Query: 361 ELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIF 420
ELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIF
Sbjct: 361 ELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIF 420
Query: 421 GKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADRT 480
GKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADRT
Sbjct: 421 GKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADRT 480
Query: 481 AELERVNRVNQCLQEDWERSAAMKKQRDLEDKAFERASDKLFLLDQCEKYRRCKQCQRRT 540
AELERVNRVNQCLQEDWERSAAMKKQRDLEDKAFERASDKLFLLDQCEKYRRCKQCQRRT
Sbjct: 481 AELERVNRVNQCLQEDWERSAAMKKQRDLEDKAFERASDKLFLLDQCEKYRRCKQCQRRT 540
Query: 541 SNVGESNLWPLNKFLPGSRLLV 562
SNVGESNLWPLNKFLPGSRLLV
Sbjct: 541 SNVGESNLWPLNKFLPGSRLLV 562
>gi|226493512 coiled-coil domain containing 81 isoform 1 [Homo
sapiens]
Length = 652
Score = 935 bits (2416), Expect = 0.0
Identities = 467/467 (100%), Positives = 467/467 (100%)
Query: 96 RPGTVDSVLSSREALRKWPSSVLAFPRIELKEMENKLPMETLVEECGENRERKCKLKDQS 155
RPGTVDSVLSSREALRKWPSSVLAFPRIELKEMENKLPMETLVEECGENRERKCKLKDQS
Sbjct: 186 RPGTVDSVLSSREALRKWPSSVLAFPRIELKEMENKLPMETLVEECGENRERKCKLKDQS 245
Query: 156 DKEEGTRDISSPKRLRDRQALFPAKVTNVSLLEKFERSESGGKIMTPESLSYPSCLKHDS 215
DKEEGTRDISSPKRLRDRQALFPAKVTNVSLLEKFERSESGGKIMTPESLSYPSCLKHDS
Sbjct: 246 DKEEGTRDISSPKRLRDRQALFPAKVTNVSLLEKFERSESGGKIMTPESLSYPSCLKHDS 305
Query: 216 EMKPQTSPACQDHNKAGQEMCYVCLQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQE 275
EMKPQTSPACQDHNKAGQEMCYVCLQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQE
Sbjct: 306 EMKPQTSPACQDHNKAGQEMCYVCLQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQE 365
Query: 276 ALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQ 335
ALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQ
Sbjct: 366 ALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQ 425
Query: 336 EEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKR 395
EEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKR
Sbjct: 426 EEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKR 485
Query: 396 ALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAIL 455
ALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAIL
Sbjct: 486 ALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAIL 545
Query: 456 HQLVDQRRDLQMLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLEDKAFE 515
HQLVDQRRDLQMLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLEDKAFE
Sbjct: 546 HQLVDQRRDLQMLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLEDKAFE 605
Query: 516 RASDKLFLLDQCEKYRRCKQCQRRTSNVGESNLWPLNKFLPGSRLLV 562
RASDKLFLLDQCEKYRRCKQCQRRTSNVGESNLWPLNKFLPGSRLLV
Sbjct: 606 RASDKLFLLDQCEKYRRCKQCQRRTSNVGESNLWPLNKFLPGSRLLV 652
Score = 194 bits (493), Expect = 2e-49
Identities = 179/547 (32%), Positives = 257/547 (46%), Gaps = 87/547 (15%)
Query: 1 MLDTIARALQDLGRQVLPTLPSLSQEEVSIIWGNVSEFVRRQLTLHKGVQIPAFGTFTFI 60
MLDTIARALQDLGRQVLPTLPSLSQEEVSIIWGNVSEFVRRQLTLHKGVQIPAFGTFTFI
Sbjct: 1 MLDTIARALQDLGRQVLPTLPSLSQEEVSIIWGNVSEFVRRQLTLHKGVQIPAFGTFTFI 60
Query: 61 RQKLEVGNNKFILIQRPVFIMVEKLVQIHGLKQNK--RPGTVDSVLSSREALRKWPSSVL 118
RQKLEVGNNKFILIQRPVFIMVEKLVQIHGLKQNK PG + P L
Sbjct: 61 RQKLEVGNNKFILIQRPVFIMVEKLVQIHGLKQNKVYTPGEI-------------PIVPL 107
Query: 119 AFPRIELKEMENKLPMETLVEECGENRERKCKLKDQSD---KEEGTRDISSPK------- 168
F I L+ N+ +E V+E R +K + K G I K
Sbjct: 108 NFVMISLEGPFNRDVVEGCVKETLLFLSRSISMKQNVEFTFKGIGVLMIRDSKVKMRFYK 167
Query: 169 ----RLRDRQALFPAKVTNVSLLEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTSPA 224
+ AL A ++ S + L++P + E K
Sbjct: 168 DFLCTMDGSGALAKALANRPGTVDSVLSSREALRKWPSSVLAFPRIELKEMENKLPMETL 227
Query: 225 CQDHNKAGQEMCYVCLQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKS 284
++ + + C + +++ + E R I + L+D++ALF ++ +
Sbjct: 228 VEECGENRERKCKL--------------KDQSDKEEGTRDISSPKRLRDRQALFPAKVTN 273
Query: 285 LATREQNQKNAA-------YNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEE 337
++ E+ +++ + +L +++ KP+ + + Q
Sbjct: 274 VSLLEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTSPACQDHNKAGQEMCYVCLQRA 333
Query: 338 YSRSLLKQMDNRQ---ENEIKQRQYRELMDRLEQVQLTEELAAQRAKFL--KDKMEETQC 392
SLL + R+ E+E +QY+ L D+ E L + K L +++ ++
Sbjct: 334 QRNSLLYYSEERRREIEDERLIQQYQMLKDQ-------EALFRHQMKSLATREQNQKNAA 386
Query: 393 YKRALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQKREQNYMKHQLEAAANHKRK 452
Y + I+N + P F +F K + K+E+ +
Sbjct: 387 YNLGVAEAIRNHKNEKPEFYKSF---LFDKRPLSPALNALKQEE-------------YSR 430
Query: 453 AILHQLVDQRRDLQMLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLEDK 512
++L Q+ D R++ ++ QR RE L DR LE+V Q +E + A K + E +
Sbjct: 431 SLLKQM-DNRQENEIKQRQYRE-LMDR---LEQV----QLTEELAAQRAKFLKDKMEETQ 481
Query: 513 AFERASD 519
++RA D
Sbjct: 482 CYKRALD 488
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 70.1 bits (170), Expect = 5e-12
Identities = 94/455 (20%), Positives = 195/455 (42%), Gaps = 44/455 (9%)
Query: 93 QNKRPGTVDSVLSSREALRKWPSSVLAFPRIELKEMENKLPMETLV-----EECGENRER 147
Q + P + E LRK L R E ++ + +L E + EE E +E
Sbjct: 261 QEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320
Query: 148 KCKLKDQSDKEEGTRDISSPKRLRDRQALFPAKVTNVSLLEKFERSESGGKIMTPESLSY 207
+ + +++ +++E R+ + +R+ + E+ R E + + L
Sbjct: 321 RREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEE-RREQQLRR 379
Query: 208 PSCLKHDSEMKPQTSPACQDHNKAGQEMCYVCLQRAQRNSLLYYSEERRREIEDERLIQQ 267
L+ + +++ + + + Q++ Q+ +R L ++ RRE E+ER Q+
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLRRE--QQLRREQQLRREQQLRREQEEERHEQK 437
Query: 268 YQM-----------------LKDQEALFRHQM---KSLATREQNQKNAAYNLGVAEAIRN 307
++ LK +E RH+ K R+Q ++ L + E R
Sbjct: 438 HEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERR 497
Query: 308 HKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQYRE-LMDRL 366
+ E+ E ++R LK++E L +++ + Q+ +Q + RE L+ R
Sbjct: 498 EQQERREQQLRREQEER----REQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE 553
Query: 367 EQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIFGKNEGE 426
E+ +L +E QR LK + EE + + L + + + RL + + E + E E
Sbjct: 554 EEKRLEQERREQR---LKREQEERR--DQLLKREEERRQQRLKREQEERLEQRLKREEVE 608
Query: 427 LMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADRTAELERV 486
+ ++++REQ + + E +R+ +L + R Q L+R Q+E R E
Sbjct: 609 RLEQEERREQRLKREEPE---EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE 665
Query: 487 NRVNQCLQEDWERSAAMKKQRDLEDKAFERASDKL 521
R+ Q L+ + E +++++L ++ E+A +++
Sbjct: 666 ERLEQRLKREHEEE---RREQELAEEEQEQARERI 697
Score = 57.4 bits (137), Expect = 3e-08
Identities = 84/405 (20%), Positives = 163/405 (40%), Gaps = 48/405 (11%)
Query: 139 EECGENRERKCKLKD-QSDKEEGTRDISSPKRLRDRQALFPAKVTNVSLLEKFERSESGG 197
+E E ER+ + + QS K T + ++LR R+ L + ++ +R E
Sbjct: 178 QEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREE--KQQQRRERQD 235
Query: 198 KIMTPES----LSYPSCLKHDSEMKPQTSPACQDHNKAGQEMCYVCLQRAQRNSLLYYSE 253
++ E + L+ + E + P Q + +E L++ +R L E
Sbjct: 236 RVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQ----LRKLERQELR--RE 289
Query: 254 ERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKP 313
+ E + +RL ++ Q+ + QE R Q + REQ ++ + +R + E+
Sbjct: 290 RQEEEQQQQRLRREQQLRRKQEEERREQQEE--RREQQERREQQEERREQQLRREQEERR 347
Query: 314 EFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTE 373
E L++E+ +Q+ QE E +++Q R + QL
Sbjct: 348 E----------------QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRR 391
Query: 374 ELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQK 433
E +R + L+ + + + + + Q++ + E + E K+E E ++ K
Sbjct: 392 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ---KHEQERREQRLK 448
Query: 434 REQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADRTAELE-------RV 486
REQ + L+ +R +Q R Q L+R Q E +R +LE +
Sbjct: 449 REQEERRDWLKREEETERH-------EQERRKQQLKRDQEEERRERWLKLEEEERREQQE 501
Query: 487 NRVNQCLQEDWERSAAMKKQRDLEDKAFERASDKLFLLDQCEKYR 531
R Q +E ER K+++ E++ +R + L + E+ R
Sbjct: 502 RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERR 546
Score = 54.3 bits (129), Expect = 3e-07
Identities = 83/412 (20%), Positives = 174/412 (42%), Gaps = 55/412 (13%)
Query: 123 IELKEMENKLPMETLVEECGENRE--RKCKLKDQSDKEEGTRDISSPKRLRDRQALFPAK 180
++L+E E + E ++ +E R+ +LK Q ++E + + S ++LR Q +
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 181 VTNVSLLEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTSPACQDHNKAGQEMCYVCL 240
+ ++ E+ ++ + LK + E + Q Q+
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE--------- 599
Query: 241 QRAQRNSLLYYSEERRREI----EDERLIQQYQMLKDQEALFRHQMK----SLATREQNQ 292
QR +R + +E RRE E+ ++ Q+LK +E R Q + REQ
Sbjct: 600 QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRL 659
Query: 293 KNAAYNLGVAEAI-RNHKNEK---------PEFYKSFLFDKRP-----LSPALNALKQEE 337
K + + + R H+ E+ E + + + P L +A + +
Sbjct: 660 KREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKV 719
Query: 338 YSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRAL 397
YSR ++ R++ + ++R+ RE ++Q EE +RA + + E+ + +
Sbjct: 720 YSRPRKQEGQRRRQEQEEKRRRRE-----SELQWQEE---ERAHRQQQEEEQRRDFTWQW 771
Query: 398 DAQIKNKPSRLPPFEPDSSEPIFGKNEGELMVE-KQKREQNYMKHQLEAAANHKRKAILH 456
A+ K++ R + P+ + E +L E +Q+REQ ++ + E +++
Sbjct: 772 QAEEKSERGRQ---RLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRR--- 825
Query: 457 QLVDQRRDLQMLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRD 508
++ ++LQ L+ ++ +R +L+ LQED ER + +++RD
Sbjct: 826 ---EREKELQFLEEEEQLQRRERAQQLQ---EEEDGLQEDQERRRSQEQRRD 871
Score = 52.8 bits (125), Expect = 8e-07
Identities = 77/412 (18%), Positives = 178/412 (43%), Gaps = 39/412 (9%)
Query: 143 ENRERKCKLKDQSDKEEGTRDISSPKRLRDRQALFPAKVTNVSLLEKFERSESGGKIMTP 202
E E++ + + + ++E+ + + ++L+ R+ + L E ER S +
Sbjct: 813 EEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQ---R 869
Query: 203 ESLSYPSCLKHDSEMKPQT---SPACQDHNKAGQEMCYVC---LQRAQRNSLLYYSEERR 256
+ L+ + + + T PA Q+ + Q++ LQR +R +ER+
Sbjct: 870 RDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQ 929
Query: 257 REIEDERLIQQYQMLKDQEALFRHQMKSLATREQN--QKNAAYNLGVAEAIRNHKNEKPE 314
E++ ++ Q+L+++ R Q + R+ Q+ LG E + + E+ +
Sbjct: 930 YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG-EEPEKRRRQEREK 988
Query: 315 FYKS----FLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENE---IKQRQYRELMDRLE 367
Y+ +++ L +++E+ R K+ + +QE E ++R+ R L +R
Sbjct: 989 KYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERER 1048
Query: 368 QVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIFGKNEGEL 427
Q + EEL + + L ++ E + ++ L+ Q + + E + + E L
Sbjct: 1049 QYREEEELQQEEEQLLGEERETRR--RQELERQYRKE------------EELQQEEEQLL 1094
Query: 428 MVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADRTAELERVN 487
E +KR + + Q +++ QL+ + R+ + Q +R++ + + E
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEE--EQLLREEREKRRRQELERQYREEEEVQQEE-- 1150
Query: 488 RVNQCLQEDWERSAAMKKQRDLEDKAFERASDKLFLLDQCEKYRRCKQCQRR 539
Q L+E+ E+ + +R ++ + ++ L ++ EK R+ ++ Q R
Sbjct: 1151 --EQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYR 1200
Score = 52.0 bits (123), Expect = 1e-06
Identities = 92/479 (19%), Positives = 198/479 (41%), Gaps = 71/479 (14%)
Query: 111 RKWPSSVLAFPRIELKEMENKLPMETLVEECGENRERKCKLKDQ---SDKEEGTRDISSP 167
R+W FP E E E ++ + R+RK + + Q ++EE R +
Sbjct: 1284 RRWQQRDRHFPEEEQLEREE--------QKEAKRRDRKSQEEKQLLREEREEKRRRQETD 1335
Query: 168 KRLRDRQALFPAKVTNVSLLEKFERS---------ESGGKIMTPESL-----SYPSCLKH 213
++ R+ + L + ++ +R E G K + E LK
Sbjct: 1336 RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKE 1395
Query: 214 DSEMKPQT--SPACQDHNKAGQEMCYVCLQRAQRNSLLYYSEE--RRREIEDERLIQQYQ 269
+ +++ Q QD ++ +E L R +R+ E+ RR+E E + L ++ Q
Sbjct: 1396 EQQLRCQEREQQLRQDRDRKFREEEQQ-LSRQERDRKFREEEQQVRRQERERKFLEEEQQ 1454
Query: 270 MLKDQEALFRHQMKSLATREQNQKNAAYN----LGVAEAIRNHKNEK---------PEFY 316
+ +++ FR + + L RE+ Q + L + +R + ++ E
Sbjct: 1455 LRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPE 1514
Query: 317 KSFLFDKRPL---SPALNALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLT- 372
+ FL +++ L L++E+ R + RQ+ + K R+ +L E+ QL+
Sbjct: 1515 RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSR 1574
Query: 373 ---------EELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIFGKN 423
EE +R + + ME+ Q +R + Q + + R F D E + +
Sbjct: 1575 QERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQ-EGQQQLRQERDRKFRED--EQLLQER 1631
Query: 424 EGELMVEKQKREQNYMKHQLEAAANHKRKAILH----------QLVDQRRDLQMLQRTQR 473
E E + +Q+R++ +++ + + + + + H QL+ + + Q+ ++ +
Sbjct: 1632 E-EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERD 1690
Query: 474 EHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLEDKAFERASDKLFLLDQCEKYRR 532
+ +L R R + LQE+ + +++ E++ + +++ L Q E+YR+
Sbjct: 1691 RKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQ-ERYRK 1748
Score = 45.1 bits (105), Expect = 2e-04
Identities = 92/473 (19%), Positives = 188/473 (39%), Gaps = 64/473 (13%)
Query: 124 ELKEMENKLPMETLVEECGENRERKCKLKD--QSDKEEGTRDISSPKRLRDRQALF---- 177
EL++ E +L E + + RER+C+ ++ Q ++E+ R+ +R ++ + +
Sbjct: 1085 ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEE 1144
Query: 178 PAKVTNVSLL----EKFERSESGGKIMTPESLSY--PSCLKHDSEMKPQTSPA--CQDHN 229
+ LL EK R E + E L L+ + E + Q ++
Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEE 1204
Query: 230 KAGQEMCYVCLQRAQRNSLLY-YSEERRREIEDERLI------QQYQMLKDQEALFRHQM 282
Q+ QR+ L + + E+ + D ++ +Q++ L+D + R
Sbjct: 1205 LQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQ 1264
Query: 283 KSL-------ATREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQ 335
+ L R++ Q+ + + E+ E ++ D++ S L +
Sbjct: 1265 QDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRK--SQEEKQLLR 1322
Query: 336 EEYSRSLLKQMDNRQENEIKQ-----------RQYRELMDRLEQVQ--------LTEELA 376
EE +Q +R+ E +Q RQ R+ R E+++ L EE
Sbjct: 1323 EEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQR 1382
Query: 377 AQR----AKFLKDK-----MEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIFGKNEGEL 427
+R KFLK++ E Q ++ D + + + +L E D E E
Sbjct: 1383 LRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK-----FREEEQ 1437
Query: 428 MVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREH-LADRTAELERV 486
V +Q+RE+ +++ + + RK + + Q R+ Q L R +R+ + +L R
Sbjct: 1438 QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ 1497
Query: 487 NRVNQCLQEDWERSAAMKKQRDLEDKAFERASDKLFLLDQCEKYRRCKQCQRR 539
R + +++ +K + E + + + FL ++ + R+ + QRR
Sbjct: 1498 ERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR 1550
Score = 44.7 bits (104), Expect = 2e-04
Identities = 68/400 (17%), Positives = 172/400 (43%), Gaps = 50/400 (12%)
Query: 124 ELKEMENKLPMETLVEECGENRERKCKLKD--QSDKEEGTRDISSPKRLRDRQALFPAKV 181
EL++ E +L E + + ER+ + KD Q ++E+ R+ +RL++R+ + +
Sbjct: 995 ELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE- 1053
Query: 182 TNVSLLEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTSPACQDHNKAGQEMCYVCLQ 241
E+ ++ E + L + E++ Q + K + LQ
Sbjct: 1054 ------EELQQEEE-------QLLGEERETRRRQELERQ-------YRKEEE------LQ 1087
Query: 242 RAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATRE---QNQKNAAYN 298
+ + L E+RRR+ + + ++ ++ +++E L R + + +E Q ++
Sbjct: 1088 QEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQ 1147
Query: 299 LGVAEAIRN--HKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEI-K 355
+ +R K + E + + ++ L++E+ R ++ R+E E+ +
Sbjct: 1148 QEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQR 1207
Query: 356 QRQYRELMDRLEQVQLTEELAAQRAKFLKD-----KMEETQCYKRALDAQIKNKPSRLPP 410
Q++ + D ++ L + ++ ++D K E + +++ D+Q++++ S+
Sbjct: 1208 QKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQ--- 1264
Query: 411 FEPDSSEPIFGKNEGELMVEKQKREQNYMKH--QLEAAANHKRKAILHQLVDQRRDLQML 468
+ + G+ + ++++R Q +H + E ++K + + + Q+L
Sbjct: 1265 ---QDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLL 1321
Query: 469 QRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRD 508
+ + E R E +R R + L ++ E +++RD
Sbjct: 1322 REEREE--KRRRQETDRKFREEEQLLQEREEQPLRRQERD 1359
Score = 44.3 bits (103), Expect = 3e-04
Identities = 64/286 (22%), Positives = 117/286 (40%), Gaps = 50/286 (17%)
Query: 253 EERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEK 312
E+R R+ DE L +Q Q +++E + A EQ Q + + H+ E
Sbjct: 162 EQRDRQRRDEELWRQRQEWQERE-------ERRAEEEQLQ-----------SCKGHETE- 202
Query: 313 PEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLT 372
EF +R L ++E+ + +Q QE E K+ + RE + R E+ +L
Sbjct: 203 -EFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261
Query: 373 EELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQ 432
EE QR + L+++ E+ R L+ Q EL E+Q
Sbjct: 262 EE-EPQRQRELQEEEEQL----RKLERQ-------------------------ELRRERQ 291
Query: 433 KREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADRTAELERVNRVNQC 492
+ EQ + + E K++ + ++RR+ Q + Q E + + R Q
Sbjct: 292 EEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQL 351
Query: 493 LQEDWERSAAMKKQRDLEDKAFERASDKLFLLDQCEKYRRCKQCQR 538
+E E + +R+ E++ E+ + L + ++ RR +Q +R
Sbjct: 352 RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRR 397
Score = 44.3 bits (103), Expect = 3e-04
Identities = 54/292 (18%), Positives = 120/292 (41%), Gaps = 39/292 (13%)
Query: 240 LQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNL 299
LQ+ + L E+RRR+ +++ ++ ++ +++E L R +
Sbjct: 966 LQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREE------------------ 1007
Query: 300 GVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQY 359
K + E+ + + L++E R L ++ +E E Q++
Sbjct: 1008 -------REKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE 1060
Query: 360 RELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPI 419
+L+ + + +EL Q K + + EE Q + + + + + R + E +
Sbjct: 1061 EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERER----QCREEEEL 1116
Query: 420 FGKNEGELMVEKQKREQNYMKHQL--EAAANHKRKAILHQLVDQRRDLQMLQRTQREHLA 477
+ E L E++KR + ++ Q E + + +L + ++RR Q L+R RE
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRR-RQELERQYRE--- 1172
Query: 478 DRTAELERVNRVNQCLQEDWERSAAMKKQRDLEDKAFERASDKLFLLDQCEK 529
E E Q L+E+ E+ ++++ E++ +R K D+ ++
Sbjct: 1173 ----EEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQR 1220
Score = 42.0 bits (97), Expect = 0.001
Identities = 70/305 (22%), Positives = 126/305 (41%), Gaps = 68/305 (22%)
Query: 253 EERRREIEDERLIQ----QYQMLKDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNH 308
E+ R+ +EDE+ ++ Q Q+ ++++ FR + L RE+ Q L E R
Sbjct: 1592 EQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQ------LHRQERDRKF 1645
Query: 309 KNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNR--------QENEIKQ--RQ 358
E+P+ L+++E + L D + QE E +Q RQ
Sbjct: 1646 LEEEPQ------------------LRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQ 1687
Query: 359 YRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEP 418
R+ R E+ QL + + KFL+ EE Q ++ L+ + + + E
Sbjct: 1688 ERDRKFREEEQQLRRQ--ERERKFLQ---EEQQLRRQELERKFREEEQLRQETEQ----- 1737
Query: 419 IFGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQ----RTQRE 474
E+ +R++ Y K E +R+ QL Q RD + + R +RE
Sbjct: 1738 -----------EQLRRQERYRKILEEEQLRPEREE--QQLRRQERDRKFREEEQLRQERE 1784
Query: 475 HLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLEDKAFERASDKLFLLDQCEKYRRCK 534
R+ E +R R + L+++ E +QR D + ++L L +Q ++ R+ +
Sbjct: 1785 EQQLRSQESDRKFREEEQLRQEREEQQLRPQQR---DGKYRWEEEQLQLEEQEQRLRQER 1841
Query: 535 QCQRR 539
Q R
Sbjct: 1842 DRQYR 1846
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 52.4 bits (124), Expect = 1e-06
Identities = 89/405 (21%), Positives = 166/405 (40%), Gaps = 63/405 (15%)
Query: 170 LRDRQALFPAKVTNVSLLEKFERSESGGKIMTPESLSYPSCLK--------HDSEMKPQT 221
L D QA+ +LLE+ ER + + Y + +K + ++++P
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297
Query: 222 SPACQDHNKAGQEMC----------YVCLQRAQRNSLLYYSEERRREIEDERLIQQYQML 271
SPA + ++G E Y L + + SE RR E+ERL +Q Q
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ-QRA 1356
Query: 272 KDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALN 331
+++E L + A +Q Q A+ A+A R K + + + R A++
Sbjct: 1357 EERERLAEVEA---ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV---RREEAAVD 1410
Query: 332 ALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKF--------- 382
A +Q+ + L+Q+ E EI+ + + ++++ EE+ R +
Sbjct: 1411 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470
Query: 383 -------LKDKMEETQCYKRA-------LDAQIKNKPSRLPPFEPDSSEPIFGKNEGELM 428
L+ + EE + KR L Q++++ R E + + + K E E
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV--KAEAEAA 1528
Query: 429 VEKQKREQ--NYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRT-------QREHLADR 479
EKQ+ Q ++ Q E A R+A + + + L+ QR+ +R A++
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588
Query: 480 TAELERVNRVNQC----LQEDWERSAAMKKQRDLEDKAFERASDK 520
TA+LER + L+E+ ER A + + + + ER ++
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Score = 38.1 bits (87), Expect = 0.022
Identities = 70/323 (21%), Positives = 134/323 (41%), Gaps = 37/323 (11%)
Query: 243 AQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYN---L 299
AQ+ +E RR+++DE Q + + E R + ++ A RE+ + A L
Sbjct: 1487 AQKRQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543
Query: 300 GVAEA---IRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQ 356
EA +R + E+ + L + + A K+ ++ + + QE +
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603
Query: 357 RQYRELMDRLEQVQLTEELAAQRAKFLKDK--MEETQCYKRALDAQIKNKPSRLPPFEPD 414
Q RE +R Q Q E A + A+ ++ ++ + + L A+ + L E +
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663
Query: 415 SSEPIF-------GKNEGELMVEKQKREQNYMKH-QLEAAANHKRKAILHQLVDQRRDLQ 466
+ GK E + + +++ EQ K QL +R A +L+ R + +
Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723
Query: 467 MLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLE-DKAFERASDKLFLLD 525
++ QR+ L + A L+R E +AA +K+++LE + A RA ++ L
Sbjct: 1724 QGEQ-QRQLLEEELARLQR------------EAAAATQKRQELEAELAKVRAEMEVLLAS 1770
Query: 526 QCEKYRRCKQCQRRTSNVGESNL 548
+ R ++ R TS + L
Sbjct: 1771 KA----RAEEESRSTSEKSKQRL 1789
Score = 36.2 bits (82), Expect = 0.082
Identities = 59/247 (23%), Positives = 97/247 (39%), Gaps = 43/247 (17%)
Query: 254 ERRREIEDERLIQQYQMLKDQEAL------FRHQMKSLATREQNQKNAAYNLGVAEAIRN 307
E+ ++ ++ L Q+ Q+ ++ L HQ L Q K A EA R
Sbjct: 2168 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA-----TEAARQ 2222
Query: 308 HKNEKPEFYKSFLFDKRPLSPALNALK---QEEYSRSLLKQMDNRQ----ENEIKQRQYR 360
+ E LF R L+ LK + E +L+ DN Q E K +Q
Sbjct: 2223 RSQVEEE-----LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2277
Query: 361 ELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRAL-DAQIKNKPSRLPPFEPDSSEPI 419
E RL +AAQ A L+ EE +RAL + +K K + E
Sbjct: 2278 EEAARLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV-------QEAT 2323
Query: 420 FGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADR 479
K E EL+ ++++ Q + E ++ + QL ++ + Q +R+ +
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQE-----DKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Query: 480 TAELERV 486
+AE ER+
Sbjct: 2379 SAEAERL 2385
Score = 31.2 bits (69), Expect = 2.6
Identities = 47/217 (21%), Positives = 88/217 (40%), Gaps = 41/217 (18%)
Query: 240 LQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNL 299
+QR Q + + ER RE E L ++ + L+ + L + + + + T +Q Q
Sbjct: 2436 IQRQQSD----HDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQQEQL------ 2484
Query: 300 GVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQY 359
E +SFL +K L ++QE+ L Q + + ++++ Q
Sbjct: 2485 ---------LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2535
Query: 360 RELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPI 419
R +Q Q+ +E QR L MEE + + + ++ K L E
Sbjct: 2536 R------QQQQMEQE--RQR---LVASMEEARRRQHEAEEGVRRKQEELQQLEQQR---- 2580
Query: 420 FGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILH 456
+ + EL+ E+ +R ++ QL+ R A+ H
Sbjct: 2581 --RQQEELLAEENQR----LREQLQLLEEQHRAALAH 2611
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 52.4 bits (124), Expect = 1e-06
Identities = 89/405 (21%), Positives = 166/405 (40%), Gaps = 63/405 (15%)
Query: 170 LRDRQALFPAKVTNVSLLEKFERSESGGKIMTPESLSYPSCLK--------HDSEMKPQT 221
L D QA+ +LLE+ ER + + Y + +K + ++++P
Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1301
Query: 222 SPACQDHNKAGQEMC----------YVCLQRAQRNSLLYYSEERRREIEDERLIQQYQML 271
SPA + ++G E Y L + + SE RR E+ERL +Q Q
Sbjct: 1302 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ-QRA 1360
Query: 272 KDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALN 331
+++E L + A +Q Q A+ A+A R K + + + R A++
Sbjct: 1361 EERERLAEVEA---ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV---RREEAAVD 1414
Query: 332 ALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKF--------- 382
A +Q+ + L+Q+ E EI+ + + ++++ EE+ R +
Sbjct: 1415 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1474
Query: 383 -------LKDKMEETQCYKRA-------LDAQIKNKPSRLPPFEPDSSEPIFGKNEGELM 428
L+ + EE + KR L Q++++ R E + + + K E E
Sbjct: 1475 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV--KAEAEAA 1532
Query: 429 VEKQKREQ--NYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRT-------QREHLADR 479
EKQ+ Q ++ Q E A R+A + + + L+ QR+ +R A++
Sbjct: 1533 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1592
Query: 480 TAELERVNRVNQC----LQEDWERSAAMKKQRDLEDKAFERASDK 520
TA+LER + L+E+ ER A + + + + ER ++
Sbjct: 1593 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1637
Score = 38.1 bits (87), Expect = 0.022
Identities = 70/323 (21%), Positives = 134/323 (41%), Gaps = 37/323 (11%)
Query: 243 AQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYN---L 299
AQ+ +E RR+++DE Q + + E R + ++ A RE+ + A L
Sbjct: 1491 AQKRQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1547
Query: 300 GVAEA---IRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQ 356
EA +R + E+ + L + + A K+ ++ + + QE +
Sbjct: 1548 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1607
Query: 357 RQYRELMDRLEQVQLTEELAAQRAKFLKDK--MEETQCYKRALDAQIKNKPSRLPPFEPD 414
Q RE +R Q Q E A + A+ ++ ++ + + L A+ + L E +
Sbjct: 1608 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1667
Query: 415 SSEPIF-------GKNEGELMVEKQKREQNYMKH-QLEAAANHKRKAILHQLVDQRRDLQ 466
+ GK E + + +++ EQ K QL +R A +L+ R + +
Sbjct: 1668 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1727
Query: 467 MLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLE-DKAFERASDKLFLLD 525
++ QR+ L + A L+R E +AA +K+++LE + A RA ++ L
Sbjct: 1728 QGEQ-QRQLLEEELARLQR------------EAAAATQKRQELEAELAKVRAEMEVLLAS 1774
Query: 526 QCEKYRRCKQCQRRTSNVGESNL 548
+ R ++ R TS + L
Sbjct: 1775 KA----RAEEESRSTSEKSKQRL 1793
Score = 36.2 bits (82), Expect = 0.082
Identities = 59/247 (23%), Positives = 97/247 (39%), Gaps = 43/247 (17%)
Query: 254 ERRREIEDERLIQQYQMLKDQEAL------FRHQMKSLATREQNQKNAAYNLGVAEAIRN 307
E+ ++ ++ L Q+ Q+ ++ L HQ L Q K A EA R
Sbjct: 2172 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA-----TEAARQ 2226
Query: 308 HKNEKPEFYKSFLFDKRPLSPALNALK---QEEYSRSLLKQMDNRQ----ENEIKQRQYR 360
+ E LF R L+ LK + E +L+ DN Q E K +Q
Sbjct: 2227 RSQVEEE-----LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2281
Query: 361 ELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRAL-DAQIKNKPSRLPPFEPDSSEPI 419
E RL +AAQ A L+ EE +RAL + +K K + E
Sbjct: 2282 EEAARLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV-------QEAT 2327
Query: 420 FGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADR 479
K E EL+ ++++ Q + E ++ + QL ++ + Q +R+ +
Sbjct: 2328 RLKAEAELLQQQKELAQEQARRLQE-----DKEQMAQQLAEETQGFQRTLEAERQRQLEM 2382
Query: 480 TAELERV 486
+AE ER+
Sbjct: 2383 SAEAERL 2389
Score = 31.2 bits (69), Expect = 2.6
Identities = 47/217 (21%), Positives = 88/217 (40%), Gaps = 41/217 (18%)
Query: 240 LQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNL 299
+QR Q + + ER RE E L ++ + L+ + L + + + + T +Q Q
Sbjct: 2440 IQRQQSD----HDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQQEQL------ 2488
Query: 300 GVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQY 359
E +SFL +K L ++QE+ L Q + + ++++ Q
Sbjct: 2489 ---------LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2539
Query: 360 RELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPI 419
R +Q Q+ +E QR L MEE + + + ++ K L E
Sbjct: 2540 R------QQQQMEQE--RQR---LVASMEEARRRQHEAEEGVRRKQEELQQLEQQR---- 2584
Query: 420 FGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILH 456
+ + EL+ E+ +R ++ QL+ R A+ H
Sbjct: 2585 --RQQEELLAEENQR----LREQLQLLEEQHRAALAH 2615
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 52.4 bits (124), Expect = 1e-06
Identities = 89/405 (21%), Positives = 166/405 (40%), Gaps = 63/405 (15%)
Query: 170 LRDRQALFPAKVTNVSLLEKFERSESGGKIMTPESLSYPSCLK--------HDSEMKPQT 221
L D QA+ +LLE+ ER + + Y + +K + ++++P
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297
Query: 222 SPACQDHNKAGQEMC----------YVCLQRAQRNSLLYYSEERRREIEDERLIQQYQML 271
SPA + ++G E Y L + + SE RR E+ERL +Q Q
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ-QRA 1356
Query: 272 KDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALN 331
+++E L + A +Q Q A+ A+A R K + + + R A++
Sbjct: 1357 EERERLAEVEA---ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV---RREEAAVD 1410
Query: 332 ALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKF--------- 382
A +Q+ + L+Q+ E EI+ + + ++++ EE+ R +
Sbjct: 1411 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470
Query: 383 -------LKDKMEETQCYKRA-------LDAQIKNKPSRLPPFEPDSSEPIFGKNEGELM 428
L+ + EE + KR L Q++++ R E + + + K E E
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV--KAEAEAA 1528
Query: 429 VEKQKREQ--NYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRT-------QREHLADR 479
EKQ+ Q ++ Q E A R+A + + + L+ QR+ +R A++
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588
Query: 480 TAELERVNRVNQC----LQEDWERSAAMKKQRDLEDKAFERASDK 520
TA+LER + L+E+ ER A + + + + ER ++
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Score = 38.1 bits (87), Expect = 0.022
Identities = 70/323 (21%), Positives = 134/323 (41%), Gaps = 37/323 (11%)
Query: 243 AQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYN---L 299
AQ+ +E RR+++DE Q + + E R + ++ A RE+ + A L
Sbjct: 1487 AQKRQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543
Query: 300 GVAEA---IRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQ 356
EA +R + E+ + L + + A K+ ++ + + QE +
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603
Query: 357 RQYRELMDRLEQVQLTEELAAQRAKFLKDK--MEETQCYKRALDAQIKNKPSRLPPFEPD 414
Q RE +R Q Q E A + A+ ++ ++ + + L A+ + L E +
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663
Query: 415 SSEPIF-------GKNEGELMVEKQKREQNYMKH-QLEAAANHKRKAILHQLVDQRRDLQ 466
+ GK E + + +++ EQ K QL +R A +L+ R + +
Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723
Query: 467 MLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLE-DKAFERASDKLFLLD 525
++ QR+ L + A L+R E +AA +K+++LE + A RA ++ L
Sbjct: 1724 QGEQ-QRQLLEEELARLQR------------EAAAATQKRQELEAELAKVRAEMEVLLAS 1770
Query: 526 QCEKYRRCKQCQRRTSNVGESNL 548
+ R ++ R TS + L
Sbjct: 1771 KA----RAEEESRSTSEKSKQRL 1789
Score = 36.2 bits (82), Expect = 0.082
Identities = 59/247 (23%), Positives = 97/247 (39%), Gaps = 43/247 (17%)
Query: 254 ERRREIEDERLIQQYQMLKDQEAL------FRHQMKSLATREQNQKNAAYNLGVAEAIRN 307
E+ ++ ++ L Q+ Q+ ++ L HQ L Q K A EA R
Sbjct: 2168 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA-----TEAARQ 2222
Query: 308 HKNEKPEFYKSFLFDKRPLSPALNALK---QEEYSRSLLKQMDNRQ----ENEIKQRQYR 360
+ E LF R L+ LK + E +L+ DN Q E K +Q
Sbjct: 2223 RSQVEEE-----LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2277
Query: 361 ELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRAL-DAQIKNKPSRLPPFEPDSSEPI 419
E RL +AAQ A L+ EE +RAL + +K K + E
Sbjct: 2278 EEAARLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV-------QEAT 2323
Query: 420 FGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADR 479
K E EL+ ++++ Q + E ++ + QL ++ + Q +R+ +
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQE-----DKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Query: 480 TAELERV 486
+AE ER+
Sbjct: 2379 SAEAERL 2385
Score = 31.2 bits (69), Expect = 2.6
Identities = 47/217 (21%), Positives = 88/217 (40%), Gaps = 41/217 (18%)
Query: 240 LQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNL 299
+QR Q + + ER RE E L ++ + L+ + L + + + + T +Q Q
Sbjct: 2436 IQRQQSD----HDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQQEQL------ 2484
Query: 300 GVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQY 359
E +SFL +K L ++QE+ L Q + + ++++ Q
Sbjct: 2485 ---------LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2535
Query: 360 RELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPI 419
R +Q Q+ +E QR L MEE + + + ++ K L E
Sbjct: 2536 R------QQQQMEQE--RQR---LVASMEEARRRQHEAEEGVRRKQEELQQLEQQR---- 2580
Query: 420 FGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILH 456
+ + EL+ E+ +R ++ QL+ R A+ H
Sbjct: 2581 --RQQEELLAEENQR----LREQLQLLEEQHRAALAH 2611
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 52.4 bits (124), Expect = 1e-06
Identities = 89/405 (21%), Positives = 166/405 (40%), Gaps = 63/405 (15%)
Query: 170 LRDRQALFPAKVTNVSLLEKFERSESGGKIMTPESLSYPSCLK--------HDSEMKPQT 221
L D QA+ +LLE+ ER + + Y + +K + ++++P
Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1265
Query: 222 SPACQDHNKAGQEMC----------YVCLQRAQRNSLLYYSEERRREIEDERLIQQYQML 271
SPA + ++G E Y L + + SE RR E+ERL +Q Q
Sbjct: 1266 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ-QRA 1324
Query: 272 KDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALN 331
+++E L + A +Q Q A+ A+A R K + + + R A++
Sbjct: 1325 EERERLAEVEA---ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV---RREEAAVD 1378
Query: 332 ALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKF--------- 382
A +Q+ + L+Q+ E EI+ + + ++++ EE+ R +
Sbjct: 1379 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1438
Query: 383 -------LKDKMEETQCYKRA-------LDAQIKNKPSRLPPFEPDSSEPIFGKNEGELM 428
L+ + EE + KR L Q++++ R E + + + K E E
Sbjct: 1439 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV--KAEAEAA 1496
Query: 429 VEKQKREQ--NYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRT-------QREHLADR 479
EKQ+ Q ++ Q E A R+A + + + L+ QR+ +R A++
Sbjct: 1497 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1556
Query: 480 TAELERVNRVNQC----LQEDWERSAAMKKQRDLEDKAFERASDK 520
TA+LER + L+E+ ER A + + + + ER ++
Sbjct: 1557 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601
Score = 38.1 bits (87), Expect = 0.022
Identities = 70/323 (21%), Positives = 134/323 (41%), Gaps = 37/323 (11%)
Query: 243 AQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYN---L 299
AQ+ +E RR+++DE Q + + E R + ++ A RE+ + A L
Sbjct: 1455 AQKRQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1511
Query: 300 GVAEA---IRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQ 356
EA +R + E+ + L + + A K+ ++ + + QE +
Sbjct: 1512 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1571
Query: 357 RQYRELMDRLEQVQLTEELAAQRAKFLKDK--MEETQCYKRALDAQIKNKPSRLPPFEPD 414
Q RE +R Q Q E A + A+ ++ ++ + + L A+ + L E +
Sbjct: 1572 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1631
Query: 415 SSEPIF-------GKNEGELMVEKQKREQNYMKH-QLEAAANHKRKAILHQLVDQRRDLQ 466
+ GK E + + +++ EQ K QL +R A +L+ R + +
Sbjct: 1632 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1691
Query: 467 MLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLE-DKAFERASDKLFLLD 525
++ QR+ L + A L+R E +AA +K+++LE + A RA ++ L
Sbjct: 1692 QGEQ-QRQLLEEELARLQR------------EAAAATQKRQELEAELAKVRAEMEVLLAS 1738
Query: 526 QCEKYRRCKQCQRRTSNVGESNL 548
+ R ++ R TS + L
Sbjct: 1739 KA----RAEEESRSTSEKSKQRL 1757
Score = 36.2 bits (82), Expect = 0.082
Identities = 59/247 (23%), Positives = 97/247 (39%), Gaps = 43/247 (17%)
Query: 254 ERRREIEDERLIQQYQMLKDQEAL------FRHQMKSLATREQNQKNAAYNLGVAEAIRN 307
E+ ++ ++ L Q+ Q+ ++ L HQ L Q K A EA R
Sbjct: 2136 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA-----TEAARQ 2190
Query: 308 HKNEKPEFYKSFLFDKRPLSPALNALK---QEEYSRSLLKQMDNRQ----ENEIKQRQYR 360
+ E LF R L+ LK + E +L+ DN Q E K +Q
Sbjct: 2191 RSQVEEE-----LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2245
Query: 361 ELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRAL-DAQIKNKPSRLPPFEPDSSEPI 419
E RL +AAQ A L+ EE +RAL + +K K + E
Sbjct: 2246 EEAARLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV-------QEAT 2291
Query: 420 FGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADR 479
K E EL+ ++++ Q + E ++ + QL ++ + Q +R+ +
Sbjct: 2292 RLKAEAELLQQQKELAQEQARRLQE-----DKEQMAQQLAEETQGFQRTLEAERQRQLEM 2346
Query: 480 TAELERV 486
+AE ER+
Sbjct: 2347 SAEAERL 2353
Score = 31.2 bits (69), Expect = 2.6
Identities = 47/217 (21%), Positives = 88/217 (40%), Gaps = 41/217 (18%)
Query: 240 LQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNL 299
+QR Q + + ER RE E L ++ + L+ + L + + + + T +Q Q
Sbjct: 2404 IQRQQSD----HDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQQEQL------ 2452
Query: 300 GVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQY 359
E +SFL +K L ++QE+ L Q + + ++++ Q
Sbjct: 2453 ---------LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2503
Query: 360 RELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPI 419
R +Q Q+ +E QR L MEE + + + ++ K L E
Sbjct: 2504 R------QQQQMEQE--RQR---LVASMEEARRRQHEAEEGVRRKQEELQQLEQQR---- 2548
Query: 420 FGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILH 456
+ + EL+ E+ +R ++ QL+ R A+ H
Sbjct: 2549 --RQQEELLAEENQR----LREQLQLLEEQHRAALAH 2579
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 52.4 bits (124), Expect = 1e-06
Identities = 89/405 (21%), Positives = 166/405 (40%), Gaps = 63/405 (15%)
Query: 170 LRDRQALFPAKVTNVSLLEKFERSESGGKIMTPESLSYPSCLK--------HDSEMKPQT 221
L D QA+ +LLE+ ER + + Y + +K + ++++P
Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434
Query: 222 SPACQDHNKAGQEMC----------YVCLQRAQRNSLLYYSEERRREIEDERLIQQYQML 271
SPA + ++G E Y L + + SE RR E+ERL +Q Q
Sbjct: 1435 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ-QRA 1493
Query: 272 KDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALN 331
+++E L + A +Q Q A+ A+A R K + + + R A++
Sbjct: 1494 EERERLAEVEA---ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV---RREEAAVD 1547
Query: 332 ALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKF--------- 382
A +Q+ + L+Q+ E EI+ + + ++++ EE+ R +
Sbjct: 1548 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1607
Query: 383 -------LKDKMEETQCYKRA-------LDAQIKNKPSRLPPFEPDSSEPIFGKNEGELM 428
L+ + EE + KR L Q++++ R E + + + K E E
Sbjct: 1608 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV--KAEAEAA 1665
Query: 429 VEKQKREQ--NYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRT-------QREHLADR 479
EKQ+ Q ++ Q E A R+A + + + L+ QR+ +R A++
Sbjct: 1666 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1725
Query: 480 TAELERVNRVNQC----LQEDWERSAAMKKQRDLEDKAFERASDK 520
TA+LER + L+E+ ER A + + + + ER ++
Sbjct: 1726 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770
Score = 38.1 bits (87), Expect = 0.022
Identities = 70/323 (21%), Positives = 134/323 (41%), Gaps = 37/323 (11%)
Query: 243 AQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYN---L 299
AQ+ +E RR+++DE Q + + E R + ++ A RE+ + A L
Sbjct: 1624 AQKRQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1680
Query: 300 GVAEA---IRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQ 356
EA +R + E+ + L + + A K+ ++ + + QE +
Sbjct: 1681 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1740
Query: 357 RQYRELMDRLEQVQLTEELAAQRAKFLKDK--MEETQCYKRALDAQIKNKPSRLPPFEPD 414
Q RE +R Q Q E A + A+ ++ ++ + + L A+ + L E +
Sbjct: 1741 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1800
Query: 415 SSEPIF-------GKNEGELMVEKQKREQNYMKH-QLEAAANHKRKAILHQLVDQRRDLQ 466
+ GK E + + +++ EQ K QL +R A +L+ R + +
Sbjct: 1801 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1860
Query: 467 MLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLE-DKAFERASDKLFLLD 525
++ QR+ L + A L+R E +AA +K+++LE + A RA ++ L
Sbjct: 1861 QGEQ-QRQLLEEELARLQR------------EAAAATQKRQELEAELAKVRAEMEVLLAS 1907
Query: 526 QCEKYRRCKQCQRRTSNVGESNL 548
+ R ++ R TS + L
Sbjct: 1908 KA----RAEEESRSTSEKSKQRL 1926
Score = 36.2 bits (82), Expect = 0.082
Identities = 59/247 (23%), Positives = 97/247 (39%), Gaps = 43/247 (17%)
Query: 254 ERRREIEDERLIQQYQMLKDQEAL------FRHQMKSLATREQNQKNAAYNLGVAEAIRN 307
E+ ++ ++ L Q+ Q+ ++ L HQ L Q K A EA R
Sbjct: 2305 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA-----TEAARQ 2359
Query: 308 HKNEKPEFYKSFLFDKRPLSPALNALK---QEEYSRSLLKQMDNRQ----ENEIKQRQYR 360
+ E LF R L+ LK + E +L+ DN Q E K +Q
Sbjct: 2360 RSQVEEE-----LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2414
Query: 361 ELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRAL-DAQIKNKPSRLPPFEPDSSEPI 419
E RL +AAQ A L+ EE +RAL + +K K + E
Sbjct: 2415 EEAARLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV-------QEAT 2460
Query: 420 FGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADR 479
K E EL+ ++++ Q + E ++ + QL ++ + Q +R+ +
Sbjct: 2461 RLKAEAELLQQQKELAQEQARRLQE-----DKEQMAQQLAEETQGFQRTLEAERQRQLEM 2515
Query: 480 TAELERV 486
+AE ER+
Sbjct: 2516 SAEAERL 2522
Score = 31.2 bits (69), Expect = 2.6
Identities = 47/217 (21%), Positives = 88/217 (40%), Gaps = 41/217 (18%)
Query: 240 LQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNL 299
+QR Q + + ER RE E L ++ + L+ + L + + + + T +Q Q
Sbjct: 2573 IQRQQSD----HDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQQEQL------ 2621
Query: 300 GVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQY 359
E +SFL +K L ++QE+ L Q + + ++++ Q
Sbjct: 2622 ---------LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2672
Query: 360 RELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPI 419
R +Q Q+ +E QR L MEE + + + ++ K L E
Sbjct: 2673 R------QQQQMEQE--RQR---LVASMEEARRRQHEAEEGVRRKQEELQQLEQQR---- 2717
Query: 420 FGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILH 456
+ + EL+ E+ +R ++ QL+ R A+ H
Sbjct: 2718 --RQQEELLAEENQR----LREQLQLLEEQHRAALAH 2748
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 52.4 bits (124), Expect = 1e-06
Identities = 89/405 (21%), Positives = 166/405 (40%), Gaps = 63/405 (15%)
Query: 170 LRDRQALFPAKVTNVSLLEKFERSESGGKIMTPESLSYPSCLK--------HDSEMKPQT 221
L D QA+ +LLE+ ER + + Y + +K + ++++P
Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1275
Query: 222 SPACQDHNKAGQEMC----------YVCLQRAQRNSLLYYSEERRREIEDERLIQQYQML 271
SPA + ++G E Y L + + SE RR E+ERL +Q Q
Sbjct: 1276 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ-QRA 1334
Query: 272 KDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALN 331
+++E L + A +Q Q A+ A+A R K + + + R A++
Sbjct: 1335 EERERLAEVEA---ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV---RREEAAVD 1388
Query: 332 ALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKF--------- 382
A +Q+ + L+Q+ E EI+ + + ++++ EE+ R +
Sbjct: 1389 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1448
Query: 383 -------LKDKMEETQCYKRA-------LDAQIKNKPSRLPPFEPDSSEPIFGKNEGELM 428
L+ + EE + KR L Q++++ R E + + + K E E
Sbjct: 1449 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV--KAEAEAA 1506
Query: 429 VEKQKREQ--NYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRT-------QREHLADR 479
EKQ+ Q ++ Q E A R+A + + + L+ QR+ +R A++
Sbjct: 1507 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1566
Query: 480 TAELERVNRVNQC----LQEDWERSAAMKKQRDLEDKAFERASDK 520
TA+LER + L+E+ ER A + + + + ER ++
Sbjct: 1567 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1611
Score = 38.1 bits (87), Expect = 0.022
Identities = 70/323 (21%), Positives = 134/323 (41%), Gaps = 37/323 (11%)
Query: 243 AQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYN---L 299
AQ+ +E RR+++DE Q + + E R + ++ A RE+ + A L
Sbjct: 1465 AQKRQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1521
Query: 300 GVAEA---IRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQ 356
EA +R + E+ + L + + A K+ ++ + + QE +
Sbjct: 1522 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1581
Query: 357 RQYRELMDRLEQVQLTEELAAQRAKFLKDK--MEETQCYKRALDAQIKNKPSRLPPFEPD 414
Q RE +R Q Q E A + A+ ++ ++ + + L A+ + L E +
Sbjct: 1582 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1641
Query: 415 SSEPIF-------GKNEGELMVEKQKREQNYMKH-QLEAAANHKRKAILHQLVDQRRDLQ 466
+ GK E + + +++ EQ K QL +R A +L+ R + +
Sbjct: 1642 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1701
Query: 467 MLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLE-DKAFERASDKLFLLD 525
++ QR+ L + A L+R E +AA +K+++LE + A RA ++ L
Sbjct: 1702 QGEQ-QRQLLEEELARLQR------------EAAAATQKRQELEAELAKVRAEMEVLLAS 1748
Query: 526 QCEKYRRCKQCQRRTSNVGESNL 548
+ R ++ R TS + L
Sbjct: 1749 KA----RAEEESRSTSEKSKQRL 1767
Score = 36.2 bits (82), Expect = 0.082
Identities = 59/247 (23%), Positives = 97/247 (39%), Gaps = 43/247 (17%)
Query: 254 ERRREIEDERLIQQYQMLKDQEAL------FRHQMKSLATREQNQKNAAYNLGVAEAIRN 307
E+ ++ ++ L Q+ Q+ ++ L HQ L Q K A EA R
Sbjct: 2146 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA-----TEAARQ 2200
Query: 308 HKNEKPEFYKSFLFDKRPLSPALNALK---QEEYSRSLLKQMDNRQ----ENEIKQRQYR 360
+ E LF R L+ LK + E +L+ DN Q E K +Q
Sbjct: 2201 RSQVEEE-----LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2255
Query: 361 ELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRAL-DAQIKNKPSRLPPFEPDSSEPI 419
E RL +AAQ A L+ EE +RAL + +K K + E
Sbjct: 2256 EEAARLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV-------QEAT 2301
Query: 420 FGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADR 479
K E EL+ ++++ Q + E ++ + QL ++ + Q +R+ +
Sbjct: 2302 RLKAEAELLQQQKELAQEQARRLQE-----DKEQMAQQLAEETQGFQRTLEAERQRQLEM 2356
Query: 480 TAELERV 486
+AE ER+
Sbjct: 2357 SAEAERL 2363
Score = 31.2 bits (69), Expect = 2.6
Identities = 47/217 (21%), Positives = 88/217 (40%), Gaps = 41/217 (18%)
Query: 240 LQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNL 299
+QR Q + + ER RE E L ++ + L+ + L + + + + T +Q Q
Sbjct: 2414 IQRQQSD----HDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQQEQL------ 2462
Query: 300 GVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQY 359
E +SFL +K L ++QE+ L Q + + ++++ Q
Sbjct: 2463 ---------LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2513
Query: 360 RELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPI 419
R +Q Q+ +E QR L MEE + + + ++ K L E
Sbjct: 2514 R------QQQQMEQE--RQR---LVASMEEARRRQHEAEEGVRRKQEELQQLEQQR---- 2558
Query: 420 FGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILH 456
+ + EL+ E+ +R ++ QL+ R A+ H
Sbjct: 2559 --RQQEELLAEENQR----LREQLQLLEEQHRAALAH 2589
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 52.4 bits (124), Expect = 1e-06
Identities = 89/405 (21%), Positives = 166/405 (40%), Gaps = 63/405 (15%)
Query: 170 LRDRQALFPAKVTNVSLLEKFERSESGGKIMTPESLSYPSCLK--------HDSEMKPQT 221
L D QA+ +LLE+ ER + + Y + +K + ++++P
Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1283
Query: 222 SPACQDHNKAGQEMC----------YVCLQRAQRNSLLYYSEERRREIEDERLIQQYQML 271
SPA + ++G E Y L + + SE RR E+ERL +Q Q
Sbjct: 1284 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ-QRA 1342
Query: 272 KDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALN 331
+++E L + A +Q Q A+ A+A R K + + + R A++
Sbjct: 1343 EERERLAEVEA---ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV---RREEAAVD 1396
Query: 332 ALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKF--------- 382
A +Q+ + L+Q+ E EI+ + + ++++ EE+ R +
Sbjct: 1397 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1456
Query: 383 -------LKDKMEETQCYKRA-------LDAQIKNKPSRLPPFEPDSSEPIFGKNEGELM 428
L+ + EE + KR L Q++++ R E + + + K E E
Sbjct: 1457 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV--KAEAEAA 1514
Query: 429 VEKQKREQ--NYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRT-------QREHLADR 479
EKQ+ Q ++ Q E A R+A + + + L+ QR+ +R A++
Sbjct: 1515 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1574
Query: 480 TAELERVNRVNQC----LQEDWERSAAMKKQRDLEDKAFERASDK 520
TA+LER + L+E+ ER A + + + + ER ++
Sbjct: 1575 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1619
Score = 38.1 bits (87), Expect = 0.022
Identities = 70/323 (21%), Positives = 134/323 (41%), Gaps = 37/323 (11%)
Query: 243 AQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYN---L 299
AQ+ +E RR+++DE Q + + E R + ++ A RE+ + A L
Sbjct: 1473 AQKRQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1529
Query: 300 GVAEA---IRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQ 356
EA +R + E+ + L + + A K+ ++ + + QE +
Sbjct: 1530 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1589
Query: 357 RQYRELMDRLEQVQLTEELAAQRAKFLKDK--MEETQCYKRALDAQIKNKPSRLPPFEPD 414
Q RE +R Q Q E A + A+ ++ ++ + + L A+ + L E +
Sbjct: 1590 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1649
Query: 415 SSEPIF-------GKNEGELMVEKQKREQNYMKH-QLEAAANHKRKAILHQLVDQRRDLQ 466
+ GK E + + +++ EQ K QL +R A +L+ R + +
Sbjct: 1650 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1709
Query: 467 MLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLE-DKAFERASDKLFLLD 525
++ QR+ L + A L+R E +AA +K+++LE + A RA ++ L
Sbjct: 1710 QGEQ-QRQLLEEELARLQR------------EAAAATQKRQELEAELAKVRAEMEVLLAS 1756
Query: 526 QCEKYRRCKQCQRRTSNVGESNL 548
+ R ++ R TS + L
Sbjct: 1757 KA----RAEEESRSTSEKSKQRL 1775
Score = 36.2 bits (82), Expect = 0.082
Identities = 59/247 (23%), Positives = 97/247 (39%), Gaps = 43/247 (17%)
Query: 254 ERRREIEDERLIQQYQMLKDQEAL------FRHQMKSLATREQNQKNAAYNLGVAEAIRN 307
E+ ++ ++ L Q+ Q+ ++ L HQ L Q K A EA R
Sbjct: 2154 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA-----TEAARQ 2208
Query: 308 HKNEKPEFYKSFLFDKRPLSPALNALK---QEEYSRSLLKQMDNRQ----ENEIKQRQYR 360
+ E LF R L+ LK + E +L+ DN Q E K +Q
Sbjct: 2209 RSQVEEE-----LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2263
Query: 361 ELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRAL-DAQIKNKPSRLPPFEPDSSEPI 419
E RL +AAQ A L+ EE +RAL + +K K + E
Sbjct: 2264 EEAARLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV-------QEAT 2309
Query: 420 FGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADR 479
K E EL+ ++++ Q + E ++ + QL ++ + Q +R+ +
Sbjct: 2310 RLKAEAELLQQQKELAQEQARRLQE-----DKEQMAQQLAEETQGFQRTLEAERQRQLEM 2364
Query: 480 TAELERV 486
+AE ER+
Sbjct: 2365 SAEAERL 2371
Score = 31.2 bits (69), Expect = 2.6
Identities = 47/217 (21%), Positives = 88/217 (40%), Gaps = 41/217 (18%)
Query: 240 LQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNL 299
+QR Q + + ER RE E L ++ + L+ + L + + + + T +Q Q
Sbjct: 2422 IQRQQSD----HDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQQEQL------ 2470
Query: 300 GVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQY 359
E +SFL +K L ++QE+ L Q + + ++++ Q
Sbjct: 2471 ---------LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2521
Query: 360 RELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPI 419
R +Q Q+ +E QR L MEE + + + ++ K L E
Sbjct: 2522 R------QQQQMEQE--RQR---LVASMEEARRRQHEAEEGVRRKQEELQQLEQQR---- 2566
Query: 420 FGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILH 456
+ + EL+ E+ +R ++ QL+ R A+ H
Sbjct: 2567 --RQQEELLAEENQR----LREQLQLLEEQHRAALAH 2597
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 52.4 bits (124), Expect = 1e-06
Identities = 89/405 (21%), Positives = 166/405 (40%), Gaps = 63/405 (15%)
Query: 170 LRDRQALFPAKVTNVSLLEKFERSESGGKIMTPESLSYPSCLK--------HDSEMKPQT 221
L D QA+ +LLE+ ER + + Y + +K + ++++P
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324
Query: 222 SPACQDHNKAGQEMC----------YVCLQRAQRNSLLYYSEERRREIEDERLIQQYQML 271
SPA + ++G E Y L + + SE RR E+ERL +Q Q
Sbjct: 1325 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ-QRA 1383
Query: 272 KDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALN 331
+++E L + A +Q Q A+ A+A R K + + + R A++
Sbjct: 1384 EERERLAEVEA---ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV---RREEAAVD 1437
Query: 332 ALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKF--------- 382
A +Q+ + L+Q+ E EI+ + + ++++ EE+ R +
Sbjct: 1438 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1497
Query: 383 -------LKDKMEETQCYKRA-------LDAQIKNKPSRLPPFEPDSSEPIFGKNEGELM 428
L+ + EE + KR L Q++++ R E + + + K E E
Sbjct: 1498 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV--KAEAEAA 1555
Query: 429 VEKQKREQ--NYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRT-------QREHLADR 479
EKQ+ Q ++ Q E A R+A + + + L+ QR+ +R A++
Sbjct: 1556 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1615
Query: 480 TAELERVNRVNQC----LQEDWERSAAMKKQRDLEDKAFERASDK 520
TA+LER + L+E+ ER A + + + + ER ++
Sbjct: 1616 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1660
Score = 38.1 bits (87), Expect = 0.022
Identities = 70/323 (21%), Positives = 134/323 (41%), Gaps = 37/323 (11%)
Query: 243 AQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYN---L 299
AQ+ +E RR+++DE Q + + E R + ++ A RE+ + A L
Sbjct: 1514 AQKRQAQEEAERLRRQVQDE---SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1570
Query: 300 GVAEA---IRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQ 356
EA +R + E+ + L + + A K+ ++ + + QE +
Sbjct: 1571 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1630
Query: 357 RQYRELMDRLEQVQLTEELAAQRAKFLKDK--MEETQCYKRALDAQIKNKPSRLPPFEPD 414
Q RE +R Q Q E A + A+ ++ ++ + + L A+ + L E +
Sbjct: 1631 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1690
Query: 415 SSEPIF-------GKNEGELMVEKQKREQNYMKH-QLEAAANHKRKAILHQLVDQRRDLQ 466
+ GK E + + +++ EQ K QL +R A +L+ R + +
Sbjct: 1691 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1750
Query: 467 MLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLE-DKAFERASDKLFLLD 525
++ QR+ L + A L+R E +AA +K+++LE + A RA ++ L
Sbjct: 1751 QGEQ-QRQLLEEELARLQR------------EAAAATQKRQELEAELAKVRAEMEVLLAS 1797
Query: 526 QCEKYRRCKQCQRRTSNVGESNL 548
+ R ++ R TS + L
Sbjct: 1798 KA----RAEEESRSTSEKSKQRL 1816
Score = 36.2 bits (82), Expect = 0.082
Identities = 59/247 (23%), Positives = 97/247 (39%), Gaps = 43/247 (17%)
Query: 254 ERRREIEDERLIQQYQMLKDQEAL------FRHQMKSLATREQNQKNAAYNLGVAEAIRN 307
E+ ++ ++ L Q+ Q+ ++ L HQ L Q K A EA R
Sbjct: 2195 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA-----TEAARQ 2249
Query: 308 HKNEKPEFYKSFLFDKRPLSPALNALK---QEEYSRSLLKQMDNRQ----ENEIKQRQYR 360
+ E LF R L+ LK + E +L+ DN Q E K +Q
Sbjct: 2250 RSQVEEE-----LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2304
Query: 361 ELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRAL-DAQIKNKPSRLPPFEPDSSEPI 419
E RL +AAQ A L+ EE +RAL + +K K + E
Sbjct: 2305 EEAARLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV-------QEAT 2350
Query: 420 FGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADR 479
K E EL+ ++++ Q + E ++ + QL ++ + Q +R+ +
Sbjct: 2351 RLKAEAELLQQQKELAQEQARRLQE-----DKEQMAQQLAEETQGFQRTLEAERQRQLEM 2405
Query: 480 TAELERV 486
+AE ER+
Sbjct: 2406 SAEAERL 2412
Score = 31.2 bits (69), Expect = 2.6
Identities = 47/217 (21%), Positives = 88/217 (40%), Gaps = 41/217 (18%)
Query: 240 LQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNL 299
+QR Q + + ER RE E L ++ + L+ + L + + + + T +Q Q
Sbjct: 2463 IQRQQSD----HDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQQEQL------ 2511
Query: 300 GVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQY 359
E +SFL +K L ++QE+ L Q + + ++++ Q
Sbjct: 2512 ---------LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2562
Query: 360 RELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPI 419
R +Q Q+ +E QR L MEE + + + ++ K L E
Sbjct: 2563 R------QQQQMEQE--RQR---LVASMEEARRRQHEAEEGVRRKQEELQQLEQQR---- 2607
Query: 420 FGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILH 456
+ + EL+ E+ +R ++ QL+ R A+ H
Sbjct: 2608 --RQQEELLAEENQR----LREQLQLLEEQHRAALAH 2638
>gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]
Length = 495
Score = 52.4 bits (124), Expect = 1e-06
Identities = 79/402 (19%), Positives = 155/402 (38%), Gaps = 75/402 (18%)
Query: 125 LKEMENKLPMETLVEECGENRERK--------------CKLKDQSDKEEGTRDISSPKRL 170
L+ + +L ME +++ EN+ K KLK +S K+E R
Sbjct: 60 LQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQ------- 112
Query: 171 RDRQALFPAKVTNVSLLEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTSPACQDHNK 230
+ R+ + L + E +I +++ Y +K D+E+ ++H +
Sbjct: 113 QVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQ-MKRDAEI---AKTMMEEHKR 168
Query: 231 AGQEMCYVCLQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQ 290
+E +R + + Y E++ E ++++ + Y+ L ++ + ++ + +Q
Sbjct: 169 IIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQ 228
Query: 291 NQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQ 350
+K K EK + ++ + + K+EE +NR+
Sbjct: 229 LEKQ-------------QKLEKMNAMRRYIEEFQKEQALWRKKKREEMEE------ENRK 269
Query: 351 ENEIKQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEE--------------------T 390
E Q + DR+ +VQ EE Q L K+EE
Sbjct: 270 IIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQA 329
Query: 391 QCYKRALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQK-REQNYMKHQLEAAANH 449
+ YK L + + K + + D E + K EL+++ K E+N+ K L A
Sbjct: 330 EIYKSKLKEEAEKKLRKQKEMKQDFEEQMALK---ELVLQAAKEEEENFRKTMLAKFAED 386
Query: 450 KR-------KAILHQLVDQRRDLQMLQRTQREHLADRTAELE 484
R K + QL +R ++++ +++ LAD+ ELE
Sbjct: 387 DRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELE 428
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 51.6 bits (122), Expect = 2e-06
Identities = 66/303 (21%), Positives = 127/303 (41%), Gaps = 34/303 (11%)
Query: 254 ERRREIEDERLIQQYQMLKDQEALFRH-QMKSLATREQNQKNAAYNLGVAEAIRNHKNEK 312
++ R+ E+ERL Q+ + + + L H Q+K RE+ ++ LG A+A ++ E
Sbjct: 602 QKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELG-AKAFKDIDIE- 659
Query: 313 PEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLT 372
D L P KQ E K++ R +N+ K+ Y E RLE++ L
Sbjct: 660 ---------DLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPL- 709
Query: 373 EELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQ 432
+K EE + + +D + + R+ + + + + KN M+E +
Sbjct: 710 ----------IKSAYEEQRI--KDMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDR 757
Query: 433 KREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADR-------TAELER 485
+K ++ K K +L ++R + L+ +R+ +R E E+
Sbjct: 758 DLFVMRLKAARQSVYEEKLKQFEERLAEERHN--RLEERKRQRKEERRITYYREKEEEEQ 815
Query: 486 VNRVNQCLQEDWERSAAMKKQRDLEDKAFERASDKLFLLDQCEKYRRCKQCQRRTSNVGE 545
Q L+E ER A + +R+ E + ++ KL +++ ++ R + +R E
Sbjct: 816 RRAEEQMLKEREERERAERAKREEELREYQERVKKLEEVERKKRQRELEIEERERRREEE 875
Query: 546 SNL 548
L
Sbjct: 876 RRL 878
Score = 34.3 bits (77), Expect = 0.31
Identities = 50/230 (21%), Positives = 99/230 (43%), Gaps = 39/230 (16%)
Query: 83 EKLVQIHGLKQNKRPGTVDSVLSSREALRKWPSSVLAFPRIELKEMENKLPMETLVEECG 142
E+++Q H + K +V E ++K AF I+++++E P + ++
Sbjct: 622 ERILQEHEQIKKK------TVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVE 675
Query: 143 ENRERKCKLKDQSDKEEGTRD-ISSPKRLRD----RQALFPAKVTNVSLLEKFERSESGG 197
+ + K +L+++ +E D KRL + + A ++ ++ L E+ E
Sbjct: 676 QLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEER--- 732
Query: 198 KIMTPESLSYPSCLKHDSEMKPQTSPACQDHN------KAGQEMCYV--------CLQRA 243
+T L L+H + M S +D + KA ++ Y L
Sbjct: 733 --ITTMQLEREKALEHKNRM----SRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEE 786
Query: 244 QRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQK 293
+ N L EER+R+ ++ER I Y+ K++E R + + L RE+ ++
Sbjct: 787 RHNRL----EERKRQRKEERRITYYRE-KEEEEQRRAEEQMLKEREERER 831
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 51.6 bits (122), Expect = 2e-06
Identities = 72/344 (20%), Positives = 152/344 (44%), Gaps = 41/344 (11%)
Query: 180 KVTNVSLLEKFERSESGGKIMTPESLSY--PSCLKHDSEMKPQTSPACQDHNKAGQEMCY 237
K + L++K RS K T E L+ P+ +++ +T+ ++ G+++
Sbjct: 123 KKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQL-Q 181
Query: 238 VCLQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAY 297
++ Q SLL +E R ++ERL +Q + L++QE Q + L +E+ +
Sbjct: 182 AEVENNQMLSLLNRRQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQEE 241
Query: 298 NL-GVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQ 356
L E +R H+ E + L L+++E ++ QE +++
Sbjct: 242 RLCEQEERLREHEERLCE-------QEERLCEQEERLREQEERLHEQEERLCEQEERLRE 294
Query: 357 RQYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSS 416
++ R L ++ E+++ EE ++ + L+++ EE C + L Q RL
Sbjct: 295 QEER-LCEQEERLREQEERLCEQEERLREQ-EERLCEQEKLPGQ-----ERL-------- 339
Query: 417 EPIFGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHL 476
E E ++E+++R++ E +R+ +L ++ + ++ Q+ +R
Sbjct: 340 -----LEEVEKLLEQERRQE-------EQERLLERERLLEEVEELLEQERLRQQDERLWQ 387
Query: 477 ADRTAELERVNRVNQCLQEDWERSAAMKKQRDLEDKAFERASDK 520
+ ELER+ + + L+ WE A+ +QR FE +++
Sbjct: 388 QETLQELERLRELERMLELGWE---ALYEQRAEPRSGFEELNNE 428
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 51.2 bits (121), Expect = 2e-06
Identities = 104/510 (20%), Positives = 202/510 (39%), Gaps = 62/510 (12%)
Query: 63 KLEVGNNKFILIQRP-VFIMVEKLVQIHGLKQNKRPGTVDSVLSSREALRKWPSSVLAFP 121
+LEV N + I +R + +E+L H K + + S LRK +
Sbjct: 631 QLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELF--- 687
Query: 122 RIELKEMENKLPMETLVEECGENRERKCKLKDQSDKEEGTRDISSPKRLRDRQALFPAKV 181
+++++ +++ + L ++ E + K D+E+G + +D Q L AK
Sbjct: 688 QVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKE 747
Query: 182 TNVSLLEKFERSESGGKIMTPESLSYPSCLKHDSEM---KPQTSPACQ------------ 226
LL K ER + K E +S HD EM K Q Q
Sbjct: 748 EQEDLLRKRERELTALKGALKEEVS-----SHDQEMDKLKEQYDAELQALRESVEEATKN 802
Query: 227 -----------DHNKAGQEMCYVCLQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQE 275
+ ++AG EM LQ + L SEE R + +L +Q + LK E
Sbjct: 803 VEVLASRSNTSEQDQAGTEMRVKLLQE-ENEKLQGRSEELERRVA--QLQRQIEDLKGDE 859
Query: 276 ALFRHQMKSLATREQNQKNAAYNLGVAE-----AIRNHKNEKPEFYKSFLFDKRPLSPAL 330
A + +K + + A + E A R +NE + +
Sbjct: 860 AKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLS 919
Query: 331 NALKQEEYSRSLLKQMDNRQENE------IKQRQYRELMDRLEQVQL-TEELAAQRAKFL 383
LK+E + L+++ N ENE ++ +E+ D +E + T EL Q ++
Sbjct: 920 EKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYK 979
Query: 384 -KDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPI-------FGKNEGELMVEKQKRE 435
K++ E + ++ + ++ + SRL + + + + + E + ++Q E
Sbjct: 980 EKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLE 1039
Query: 436 QNY--MKHQLEAAANHK--RKAILHQLVDQRRDLQMLQRTQREHLADRTAELERVNRVNQ 491
Q ++++LEA ++ K R ++ Q+ D+ L+M +R + + + R +
Sbjct: 1040 QTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQME 1099
Query: 492 CLQEDWERSAAMKKQRDLEDKAFERASDKL 521
L+ + + A ++ + + + ER + L
Sbjct: 1100 QLRNELLQERAARQDLECDKISLERQNKDL 1129
Score = 38.1 bits (87), Expect = 0.022
Identities = 60/284 (21%), Positives = 115/284 (40%), Gaps = 49/284 (17%)
Query: 258 EIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNLGV-AEAIRNHKNEKPEFY 316
E++D L++Q L + A + Q++ +QN K + E +R+ NEK E
Sbjct: 608 EVKD--LLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVE-- 663
Query: 317 KSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELA 376
+ L L + E ++L + + E E Q + R+L D+L ++
Sbjct: 664 -----ENSTLQQRLEE-SEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMH------ 711
Query: 377 AQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQKREQ 436
+E KR+ D + L + D + + K E E ++ K++RE
Sbjct: 712 -----------DELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKREREL 760
Query: 437 NYMKHQL-EAAANHKR-------------KAILHQLVDQRRDLQML---QRTQREHLADR 479
+K L E ++H + +A+ + + +++++L T + A
Sbjct: 761 TALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGT 820
Query: 480 TAELERVNRVNQCLQ---EDWERSAAMKKQRDLEDKAFERASDK 520
++ + N+ LQ E+ ER A + QR +ED + A K
Sbjct: 821 EMRVKLLQEENEKLQGRSEELERRVA-QLQRQIEDLKGDEAKAK 863
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 50.8 bits (120), Expect = 3e-06
Identities = 87/427 (20%), Positives = 172/427 (40%), Gaps = 69/427 (16%)
Query: 123 IELKEMENKLPMETLVEECGENRERKCKLKDQSDKEEGTR--DISSPKRLRDRQALFPAK 180
I ++ +LP E ++E+ + E+K + + K E ++ KR RQAL +
Sbjct: 320 ISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKR---RQALLEQQ 376
Query: 181 VTNVSLLEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTSPACQDHNKAGQEM--CYV 238
L + ER+E K + L+ + +++ Q Q + +E+
Sbjct: 377 RKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREA 436
Query: 239 CLQRAQRNSLLYYSEERRREIEDERLIQQYQMLK----------DQEALF--RHQMKS-- 284
+ +R L + RR+E+ ++R +Q ++ + EAL +HQ++
Sbjct: 437 AKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKL 496
Query: 285 ------LATREQN--QKNAAYNLGVAEA--IRNHKNEKPEFYKSFLFDKRPLSPALNALK 334
L T+ Q N + L +AE ++ E + + +K+ L+ L ++
Sbjct: 497 QDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQ 556
Query: 335 QEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYK 394
Q R L + E + RQ+ L D+L++V+ Q ++++E +
Sbjct: 557 QNSLHRDSLVTLKRALEAKELARQH--LRDQLDEVEKETRSKLQEIDIFNNQLKELR--- 611
Query: 395 RALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAI 454
+I NK +L + +E + K + ++E +K+++ +
Sbjct: 612 -----EIHNK-QQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRA------------ 653
Query: 455 LHQLVDQRRDLQMLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLEDKAF 514
Q RD Q L+ Q+E R +L +E +R ++KK +D E+K
Sbjct: 654 ------QERDKQWLEHVQQEDEHQRPRKLHE--------EEKLKREESVKK-KDGEEKGK 698
Query: 515 ERASDKL 521
+ A DKL
Sbjct: 699 QEAQDKL 705
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 50.8 bits (120), Expect = 3e-06
Identities = 87/427 (20%), Positives = 172/427 (40%), Gaps = 69/427 (16%)
Query: 123 IELKEMENKLPMETLVEECGENRERKCKLKDQSDKEEGTR--DISSPKRLRDRQALFPAK 180
I ++ +LP E ++E+ + E+K + + K E ++ KR RQAL +
Sbjct: 320 ISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKR---RQALLEQQ 376
Query: 181 VTNVSLLEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTSPACQDHNKAGQEM--CYV 238
L + ER+E K + L+ + +++ Q Q + +E+
Sbjct: 377 RKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREA 436
Query: 239 CLQRAQRNSLLYYSEERRREIEDERLIQQYQMLK----------DQEALF--RHQMKS-- 284
+ +R L + RR+E+ ++R +Q ++ + EAL +HQ++
Sbjct: 437 AKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKL 496
Query: 285 ------LATREQN--QKNAAYNLGVAEA--IRNHKNEKPEFYKSFLFDKRPLSPALNALK 334
L T+ Q N + L +AE ++ E + + +K+ L+ L ++
Sbjct: 497 QDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQ 556
Query: 335 QEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYK 394
Q R L + E + RQ+ L D+L++V+ Q ++++E +
Sbjct: 557 QNSLHRDSLVTLKRALEAKELARQH--LRDQLDEVEKETRSKLQEIDIFNNQLKELR--- 611
Query: 395 RALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAI 454
+I NK +L + +E + K + ++E +K+++ +
Sbjct: 612 -----EIHNK-QQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRA------------ 653
Query: 455 LHQLVDQRRDLQMLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLEDKAF 514
Q RD Q L+ Q+E R +L +E +R ++KK +D E+K
Sbjct: 654 ------QERDKQWLEHVQQEDEHQRPRKLHE--------EEKLKREESVKK-KDGEEKGK 698
Query: 515 ERASDKL 521
+ A DKL
Sbjct: 699 QEAQDKL 705
>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
Length = 2649
Score = 50.8 bits (120), Expect = 3e-06
Identities = 93/447 (20%), Positives = 191/447 (42%), Gaps = 56/447 (12%)
Query: 124 ELKEMENKLPMET-LVEECGENRERKC----------KLKDQSDKEEGTRDISSPKRLRD 172
ELK+ ++++ E V E EN RK K++ +S+ ++ R++ + R ++
Sbjct: 1149 ELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKE 1208
Query: 173 RQALFPAKVTNVSLLEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTSPACQDHNKAG 232
+V +++ + +R+ ++ ++ E T +DH K
Sbjct: 1209 AAERELERVRQLTIEAEAKRAAVEENLLN---------FRNQLEENTFTRRTLEDHLKR- 1258
Query: 233 QEMCYVCLQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQ 292
+++ L++ Q+N L+ EE RR+ ++E + + +++ F+ Q+ +E+ +
Sbjct: 1259 KDLSLNDLEQ-QKNKLM---EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQK 1314
Query: 293 KNAAYNLGVAEAIRN-HKNEKPEFYKSFLFDKRPLSPALNALKQE---EYSRSLLKQMDN 348
+ E +N P + R A+ L+QE + + L +Q+D
Sbjct: 1315 IELEARRKITEIQYTCRENALPVCPITQATSCR----AVTGLQQEHDKQKAEELKQQVDE 1370
Query: 349 -RQENEIKQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSR 407
N ++ REL L +QL + + ++A+ LKDK++ET R L +++ K
Sbjct: 1371 LTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQA 1430
Query: 408 LPPFEPDSSE------PIFGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQ 461
+ E GK E E M E ++ +QLE + + K L + VD+
Sbjct: 1431 EKGYSQQLRELGRQLNQTTGKAE-EAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDR 1489
Query: 462 RRDLQMLQRTQREHLADR------TAELERV---NRVNQCLQEDWERS-----AAMKKQR 507
+ +HL + ELER+ R + L+E +E+S +K ++
Sbjct: 1490 ITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549
Query: 508 DLEDKAFERASDKLFLLDQCEKYRRCK 534
+ DK +R +++L ++C + + K
Sbjct: 1550 ENNDK-IQRLNEELEKSNECAEMLKQK 1575
Score = 39.3 bits (90), Expect = 0.010
Identities = 84/408 (20%), Positives = 169/408 (41%), Gaps = 47/408 (11%)
Query: 124 ELKEMENKLPMETLVEECGENRERKCKLKDQSDKEEGTRDISSPKRLRDRQALFPAKVTN 183
+L++ +NKL ME L + +N E KL Q +K+ + + K+L+++Q +
Sbjct: 1265 DLEQQKNKL-MEELRRK-RDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRK 1322
Query: 184 VSLLEKFERSESGGKIMTPESLSYPSCL----KHDS----EMKPQTSPACQDHNKAGQEM 235
++ ++ R + ++ S + +HD E+K Q + KA Q+M
Sbjct: 1323 ITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDM 1382
Query: 236 CYVCLQRAQRNSLLYYSEERRREIEDE--------RLIQQYQMLKDQ-EALFRHQMKSLA 286
+ + SEE+ R ++D+ R ++ KDQ E + Q++ L
Sbjct: 1383 RELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELG 1442
Query: 287 TREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQE--EYSRSLLK 344
R+ NQ G AE ++ + +++ + L+ L++E +R+
Sbjct: 1443 -RQLNQTT-----GKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAV 1496
Query: 345 QMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNK 404
N Q + +R+ + LE++Q+ + +++ LK++ E++ L IK +
Sbjct: 1497 AEKNIQHLNSQIHSFRDEKE-LERLQICQ----RKSDHLKEQFEKSH---EQLLQNIKAE 1548
Query: 405 PSRLPPFEPDSSEPIFGKNEGELM---VEKQKREQNYMKHQLEAAANHKRKAILH-QLVD 460
+ + E E++ VE+ R+ N K ++ +L Q +
Sbjct: 1549 KENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQ 1608
Query: 461 QRRDLQMLQ--------RTQREHLADRTAELERVNRVNQCLQEDWERS 500
QR + +Q R+ EHL +T + R +CL+ED +S
Sbjct: 1609 QRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKS 1656
Score = 32.0 bits (71), Expect = 1.5
Identities = 51/271 (18%), Positives = 112/271 (41%), Gaps = 27/271 (9%)
Query: 240 LQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQ-EALFRHQMKSLATREQNQK----- 293
+QR Q S E++ + E L Q KDQ + H K T + Q+
Sbjct: 1590 MQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCL 1649
Query: 294 --NAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQE--------EYSRSLL 343
+ A + + + +++ ++ + R L+ LNA K+E + ++ +
Sbjct: 1650 EEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQV 1709
Query: 344 KQMDNRQ---ENEIKQRQYRELMDRLEQVQLTEELAA--QRAKFLKDKMEETQCYKRALD 398
++++NR ++E+ + E M + V EE Q A+ + KME+ K +
Sbjct: 1710 QELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITE 1769
Query: 399 AQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQKREQNYMKHQLEAA----ANHKRKA- 453
I + ++S E +++ +R+ + Q++ ANH +K
Sbjct: 1770 NDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQ 1829
Query: 454 -ILHQLVDQRRDLQMLQRTQREHLADRTAEL 483
+ +L+ Q+R+++ L++ + + + +L
Sbjct: 1830 KLEDELIAQKREVENLKQKMDQQIKEHEHQL 1860
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 50.1 bits (118), Expect = 5e-06
Identities = 57/298 (19%), Positives = 124/298 (41%), Gaps = 78/298 (26%)
Query: 213 HDSEMKPQTS----------PACQDHNKAGQEMCYVCLQRAQRNSLLYYSEERRREIEDE 262
H E+KP+ Q+ + Q+ + Q+AQ +L E+ +++++++
Sbjct: 142 HHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQ 201
Query: 263 RLIQQYQ-------MLKDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKPEF 315
+L+QQ Q +L+ QE L + Q + + Q Q+
Sbjct: 202 QLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQ--------------------- 240
Query: 316 YKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEEL 375
L +Q + + LL+Q + + ++ ++Q +L +L +Q E+L
Sbjct: 241 -------------LLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQL-LLQQQEQL 286
Query: 376 AAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELM------- 428
Q+ + L + +E Q++ + + PP EP+ E + E ELM
Sbjct: 287 QQQQQQQLLQQQQE----------QLQQQQLQPPPLEPEEEEEV----ELELMPVDLGSE 332
Query: 429 --VEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADRTAELE 484
+E+Q++E ++ Q E +++ + +L ++ + L+ Q++ L + +LE
Sbjct: 333 QELEQQRQE---LERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLE 387
Score = 37.0 bits (84), Expect = 0.048
Identities = 37/206 (17%), Positives = 96/206 (46%), Gaps = 14/206 (6%)
Query: 343 LKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAA----QRAKFLKDKMEETQCYKRALD 398
L+Q++ + E + +Q Q+ +L ++L ++ Q ++ ++K + + +
Sbjct: 91 LQQLEQQPEPQ-QQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPE 149
Query: 399 AQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQL 458
Q+ ++ +L P + + + + + E + +Q +EQ ++ Q + + + +L Q
Sbjct: 150 LQLMHQQQQLQPQQVQEQQRL--QQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQ 207
Query: 459 VDQRRDLQMLQRTQREHLADRTAELERVNRVNQCL----QEDWERSAAMKKQRDLEDKAF 514
+Q + Q+LQ+ ++ + E++ + Q L Q ++ ++Q L+ +
Sbjct: 208 QEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLL 267
Query: 515 ERASDKL---FLLDQCEKYRRCKQCQ 537
E+ +L LL Q E+ ++ +Q Q
Sbjct: 268 EQQQAQLQQQLLLQQQEQLQQQQQQQ 293
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 50.1 bits (118), Expect = 5e-06
Identities = 96/455 (21%), Positives = 180/455 (39%), Gaps = 98/455 (21%)
Query: 127 EMENKLPMETLVEECGENRERKCKLKDQSDKEEGTRDISSPKRLRDRQALFPAKVTNVSL 186
EME K+ T V E KL+D + ++E T+ I K Q K L
Sbjct: 876 EMEQKVKSLTQVYES--------KLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEIL 927
Query: 187 LEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTSPACQDHNKAGQEMCYVCLQRAQRN 246
+K E I+ E ++++ K Q + KA + +Q +
Sbjct: 928 TQKLSAKEDSIHILNEE---------YETKFKNQEKKMEKVKQKAKE------MQETLKK 972
Query: 247 SLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNLGVAEAI- 305
LL + ++E+E+ L L +E F +M +A Q N+A G+++A+
Sbjct: 973 KLLDQEAKLKKELENTAL-----ELSQKEKQFNAKMLEMA-----QANSA---GISDAVS 1019
Query: 306 RNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQE-NEI----KQRQYR 360
R N+K + +R L+ ++ + + L +Q + QE +EI K+++
Sbjct: 1020 RLETNQKEQIESLTEVHRRELNDVISI-----WEKKLNQQAEELQEIHEIQLQEKEQEVA 1074
Query: 361 ELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIF 420
EL ++ +E + +LK++ + L Q+K K + + D ++
Sbjct: 1075 ELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKA 1134
Query: 421 GKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADRT 480
+ E+ + K +E +++ QL +L+ML + +++ T
Sbjct: 1135 HLEKLEVDLNKSLKENTFLQEQLV-------------------ELKMLAEEDKRKVSELT 1175
Query: 481 AELERVNRVNQCLQEDWERSAAMKKQRDLEDKA--FERASDKLFL-LDQCEK-------- 529
++L+ + Q L+ E+S + LEDK+ F++ S++L + LD C K
Sbjct: 1176 SKLKTTDEEFQSLKSSHEKS-----NKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEA 1230
Query: 530 ----------------YRRCKQCQRRTSNVGESNL 548
R CQ RT+ V E+ L
Sbjct: 1231 KTNELINISSSKTNAILSRISHCQHRTTKVKEALL 1265
Score = 44.7 bits (104), Expect = 2e-04
Identities = 82/422 (19%), Positives = 169/422 (40%), Gaps = 97/422 (22%)
Query: 122 RIELKEMENKLPMETLVEECGENRERKCKLKDQSDKEEGTRDISSPKRLRDRQALFPAKV 181
RI L++ +++ E + + E+ KL+ +KE ++ K+L+ R+ F ++
Sbjct: 452 RISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQM 511
Query: 182 TNVSLLEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTSPACQDHNKAGQEMCYVCLQ 241
V+L E+S+S LK E + Q S A ++
Sbjct: 512 -KVAL----EKSQS-------------EYLKISQEKEQQESLALEE-------------L 540
Query: 242 RAQRNSLLYYSEERRREIEDE------RLIQQYQMLKDQEALFRHQMKSLATREQNQKNA 295
Q+ ++L SE + R+++ E R+++ L+ ++Q K LA + +KN
Sbjct: 541 ELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN- 599
Query: 296 AYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIK 355
+N + + HK E L +LK ++ + ++ ++
Sbjct: 600 KHNKEITVMVEKHKTE------------------LESLKHQQDALW-------TEKLQVL 634
Query: 356 QRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALD----AQIKNKPSRLPPF 411
++QY+ M++L E+ ++ LKDK Q + ++ ++ K + L
Sbjct: 635 KQQYQTEMEKLR-----EKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESL 689
Query: 412 EPDSSEPIFGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQ-------------- 457
+ SE + +++ E + K + + MK +LEA + ++ Q
Sbjct: 690 SSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQR 749
Query: 458 ----LVDQRRDLQMLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLEDKA 513
L DQ L++L + + +HL + A +E L+ D +RS +Q +
Sbjct: 750 TEKALKDQINQLELLLKERDKHLKEHQAHVEN-------LEADIKRSEGELQQASAKLDV 802
Query: 514 FE 515
F+
Sbjct: 803 FQ 804
Score = 42.7 bits (99), Expect = 9e-04
Identities = 79/369 (21%), Positives = 144/369 (39%), Gaps = 78/369 (21%)
Query: 178 PAKVTNVSLLEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTS--PACQDHNKAGQEM 235
P + K E ES G+ + + S + +K Q + C++ ++ +E
Sbjct: 249 PQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQ 308
Query: 236 CYVCLQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNA 295
C +LL +E +E DERL Q+ + +KD L + L T+ ++ KN
Sbjct: 309 C----------TLLTSEKEALQEQLDERL-QELEKIKD---LHMAEKTKLITQLRDAKN- 353
Query: 296 AYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYS--RSLLKQMDNRQEN- 352
+ E + K KR + L +K+EE + RS +KQM + E
Sbjct: 354 -----LIEQLEQDKG------MVIAETKRQMHETLE-MKEEEIAQLRSRIKQMTTQGEEL 401
Query: 353 -EIKQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEE--------------------TQ 391
E K++ R + LE+ T + + + LK +M+E ++
Sbjct: 402 REQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSR 461
Query: 392 CYKRALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQKREQNY---MKHQLEAAAN 448
+ +D K+ ++ + E + E EL + Q RE+ + MK LE + +
Sbjct: 462 VKQEVVDVMKKSSEEQIAKLQK-LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQS 520
Query: 449 H---------------------KRKAILHQLVDQRRDLQMLQRTQREHLADRTAELERVN 487
++KAIL + ++ RDLQ T R + + + LE+
Sbjct: 521 EYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSL 580
Query: 488 RVNQCLQED 496
+ N+ +D
Sbjct: 581 QENKNQSKD 589
Score = 37.0 bits (84), Expect = 0.048
Identities = 81/397 (20%), Positives = 160/397 (40%), Gaps = 55/397 (13%)
Query: 143 ENRERKCKLKDQSDKEEGTRDISSPKRLRDRQALFPAKVTNVSLLEKFERSESGGKIMTP 202
EN ++CK QS KE+ T S + L+++ ++ + L E+++ ++
Sbjct: 292 ENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDA 351
Query: 203 ESLSYPSCLKHDSEMKPQTSPACQDHNKAGQEMCYVCLQRAQRNSLLYYSEERRREIEDE 262
++L L+ D M + Q H + + R++ + EE R + E
Sbjct: 352 KNLI--EQLEQDKGMVIAETKR-QMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKE-- 406
Query: 263 RLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKPE----FYKS 318
K + A F K+L+T ++ + EA R K E E K+
Sbjct: 407 ---------KSERAAFEELEKALSTAQKTE----------EARRKLKAEMDEQIKTIEKT 447
Query: 319 FLFDKRPLSPALNALKQE------EYSRSLLKQMDNRQENEIKQRQYRELMDRLE----- 367
++ L L+ +KQE + S + ++ E E+ +++ +EL +L+
Sbjct: 448 SEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKE-QELTKKLQTRERE 506
Query: 368 -QVQLTEELAAQRAKFLKDK----------MEETQCYKRALDAQIKNKPSRL-PPFEPDS 415
Q Q+ L ++++LK +EE + K+A+ + +NK L E
Sbjct: 507 FQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYR 566
Query: 416 SEPIFGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREH 475
+ + ++ E +++ K + + LEA N K I + + +L+ L+ Q
Sbjct: 567 TRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQD-- 624
Query: 476 LADRTAELERVNRVNQCLQEDWERSAAMKKQRDLEDK 512
A T +L+ + + Q E +K+ L+DK
Sbjct: 625 -ALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDK 660
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 49.7 bits (117), Expect = 7e-06
Identities = 62/333 (18%), Positives = 138/333 (41%), Gaps = 56/333 (16%)
Query: 241 QRAQRNSLLYYSEERRREIEDERLIQQ--------------------------------- 267
Q+ + + LYYS++ R+ ED L +
Sbjct: 100 QKTELETALYYSQDAARKFEDGNLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADR 159
Query: 268 --YQMLKDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRP 325
++ K+++AL ++ T E+ +K N + E +R ++EK E + KR
Sbjct: 160 YIEELTKERDALSLELYRNTITNEELKKK---NAELQEKLRLAESEKSEIQLNVKELKRK 216
Query: 326 LSPALNALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKFLKD 385
L E ++ LL Q+ E RQ EL ++ ++++ EE ++ + L++
Sbjct: 217 L----------ERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLRE 266
Query: 386 ---KMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQKR---EQNYM 439
KM E + R + +++ + L E + E + + E M E++++ ++ M
Sbjct: 267 QEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKM 326
Query: 440 KHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADRTAELERVNRVNQCLQEDWER 499
+ Q E + + L + Q R+ + R Q E + ++ L + ++ WE+
Sbjct: 327 REQEEKMWRQEER--LWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ 384
Query: 500 SAAMKKQRDLEDKAFERASDKLFLLDQCEKYRR 532
M+++ + ++ + ++ + +Q EK ++
Sbjct: 385 EEKMQEEERIREREKKMREEEETMREQEEKMQK 417
Score = 47.0 bits (110), Expect = 5e-05
Identities = 73/421 (17%), Positives = 182/421 (43%), Gaps = 35/421 (8%)
Query: 124 ELKEMENKL--PMETLVEECGENRERKCKLKDQSDK--EEGTRDISSPKRLRDRQALFPA 179
+++E E K+ E L E+ + RE++ K++DQ ++ E+ R +R+R+++ ++
Sbjct: 325 KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ 384
Query: 180 KVTNVSLLEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTSPACQDHNKAGQ------ 233
+ +++ ER K M E + + + +M+ Q + K Q
Sbjct: 385 E----EKMQEEERIREREKKMREEE---ETMREQEEKMQKQEENMWEQEEKEWQQQRLPE 437
Query: 234 --EMCYVCLQRAQRNSLLYYSEERRREIED----ERLIQQYQMLKDQEALFRHQMKSLAT 287
E + + ++ ++ EE+ R+ E+ E+ + + + +++QE Q + +
Sbjct: 438 QKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD 497
Query: 288 REQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYS---RSLLK 344
+EQ + + + K E+ K + + +QE+ + ++
Sbjct: 498 QEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMR 557
Query: 345 QMDNRQENEIKQRQYRELM-DRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKN 403
+ + +E E K R+ E+M ++ E++Q EE ++ + + ++ E+ Q + + Q +
Sbjct: 558 EEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEK 617
Query: 404 KPSRLPPFEPDSSEPIFGKNEGELMVEKQK--REQNYMKHQLEAAANHKRKAILHQLVDQ 461
+ + E + + E ++ +++K ++ M+ Q E + K + ++
Sbjct: 618 MWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEK--MQGQEEK 675
Query: 462 RRDLQMLQRTQREHLADRTAELERVNRVNQCLQED--WERSAAMKKQRDLEDKAFERASD 519
R+ + + Q E + ++ ++ R QE+ W + M Q ++ +K ER D
Sbjct: 676 MREQEEKMQGQEEKMREQEEKM-RGQEEKMWGQEEKMWGQEEKMWGQEEMREKE-ERIRD 733
Query: 520 K 520
+
Sbjct: 734 Q 734
Score = 46.6 bits (109), Expect = 6e-05
Identities = 65/327 (19%), Positives = 137/327 (41%), Gaps = 42/327 (12%)
Query: 253 EERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNE- 311
+E + ++ERL +Q +++QE R Q K L +E+ + L + +R + +
Sbjct: 253 QEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQM 312
Query: 312 --------------KPEFYKSFLFDKRPLSPALNALKQEEYSRS----LLKQMDNRQENE 353
+ + K + ++R +QE+ R + +Q + +E E
Sbjct: 313 QEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKE 372
Query: 354 IKQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKN---------K 404
+ R+ ++ ++ E++Q EE +R K ++++ E + + + Q +N +
Sbjct: 373 ERMREQEKMWEQEEKMQ-EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ 431
Query: 405 PSRLPPFEPDSSEPIFGKNEGELMVEKQKREQNYMKHQLEAAANHK---RKAILHQLVDQ 461
RL P+ E ++ + + + EK ++ ++ Q E K R+ + + DQ
Sbjct: 432 QQRL----PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQ 487
Query: 462 RRDLQMLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLEDKAFER---AS 518
+ + R Q + + D+ ER+ ++ L+E ER KK E+K E
Sbjct: 488 MWEQEEKMRDQEQKMWDQE---ERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQE 544
Query: 519 DKLFLLDQCEKYRRCKQCQRRTSNVGE 545
+ DQ EK R ++ + R + E
Sbjct: 545 QEKKTWDQEEKMREEERMREREKKMRE 571
Score = 37.7 bits (86), Expect = 0.028
Identities = 36/201 (17%), Positives = 89/201 (44%), Gaps = 20/201 (9%)
Query: 254 ERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNLGVAE--AIRNHKNE 311
E++ E+E + +Q + +++QE R Q + + +E+ + + E + +
Sbjct: 566 EKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEED 625
Query: 312 KPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQL 371
K + + ++++ K +E + +Q + +E E K R+ E M E+
Sbjct: 626 KMQEQEEMMWEQEE--------KMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMR 677
Query: 372 TEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEK 431
+E ++ + ++KM E + R + ++ + ++ E E ++G+ E M EK
Sbjct: 678 EQE---EKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQE----EKMWGQEE---MREK 727
Query: 432 QKREQNYMKHQLEAAANHKRK 452
++R ++ + E H+ +
Sbjct: 728 EERIRDQKEKMQERLPEHEER 748
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 49.7 bits (117), Expect = 7e-06
Identities = 42/175 (24%), Positives = 73/175 (41%), Gaps = 22/175 (12%)
Query: 350 QENEI--KQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKN---- 403
QE E+ Q Q EL+ RL++ Q E A + + L ++EE + +R L+AQ+ +
Sbjct: 508 QEQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQ 567
Query: 404 -------------KPSRLPPFEPDSSEPIFGKNEGELMVEKQKREQNYMKHQLEAAANHK 450
+ S+ S G EG + ++E ++ QLE A +H+
Sbjct: 568 VTQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHR 627
Query: 451 ---RKAILHQLVDQRRDLQMLQRTQREHLADRTAELERVNRVNQCLQEDWERSAA 502
++ L QL ++ R L Q LA +R+ + + +WE A
Sbjct: 628 PSGKEEALCQLQEENRRLSREQERLEAELAQEQESKQRLEGERRETESNWEAQLA 682
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 48.9 bits (115), Expect = 1e-05
Identities = 64/326 (19%), Positives = 138/326 (42%), Gaps = 29/326 (8%)
Query: 240 LQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQ--KNAAY 297
L ++++ + ++ +R++E +L+ Q L+ + +++S++ + Q Q +N +
Sbjct: 229 LVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELW 288
Query: 298 NLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQR 357
NL N + E+ + + ++ LK E + +Q + E E K R
Sbjct: 289 NL------LNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIR 342
Query: 358 QYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSE 417
+ + M R E+ +E ++ + ++KM + R D +I+ + + E E
Sbjct: 343 EQEDKMWRQEEKIREQE---EKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE 399
Query: 418 PIFGKNEGELMVEKQKREQNYMKHQLEAAA---NHKRKAILHQLVDQRRDLQMLQRTQRE 474
+ E EK+ REQ+ + E K + + + DQ L+ ++ +E
Sbjct: 400 QEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQE 459
Query: 475 HLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLEDKAFE------RASDKLF-----L 523
+ E++ R + +QE E++ +K E+K +E R +K++ +
Sbjct: 460 EEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKM 519
Query: 524 LDQCEKYRRCKQCQRRTSNVGESNLW 549
+Q EK +R ++ R E LW
Sbjct: 520 QEQEEKMQRQEEKMREQ----EVRLW 541
Score = 40.0 bits (92), Expect = 0.006
Identities = 74/384 (19%), Positives = 167/384 (43%), Gaps = 32/384 (8%)
Query: 121 PRIELKEMENKLPMETLVEECGENRERKCKLKDQSDKEEGTRDISSPKRLRDR-QALFPA 179
P +EL N + E L E+ E +E K +L + S+K E ++ KR +R Q L P
Sbjct: 202 PSLEL--YRNTITDEELKEKNAELQE-KLRLVE-SEKSEIQLNVKDLKRKLERAQLLLPQ 257
Query: 180 KVTNVSL--LEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTSPACQDHNKAGQEMCY 237
+ V L K +S S E + L E K + + ++MC
Sbjct: 258 QQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQE--EKIQEQEEKMCE 315
Query: 238 VCLQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAY 297
L+ ++ ++ EE+ E ++E++ +Q + QE R Q + + REQ +K
Sbjct: 316 QELKIREQEEKMWRQEEKMHE-QEEKIREQEDKMWRQEEKIREQEEKI--REQEEKMWRQ 372
Query: 298 NLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQR 357
+ E + ++ E ++ + +++ + ++ R+++E +
Sbjct: 373 EEKIREQDEKIQEQEEEMWRQ--------EEKIREQEEKRQEKMWRQEKKMREQDEKIRE 424
Query: 358 QYRELMDRLEQVQLTEEL---AAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPD 414
Q E+ + E+++ EE+ ++ + +++KM+E + + + +I+ + ++ E
Sbjct: 425 QEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEK 484
Query: 415 S-SEPIFGKNEGELMVEKQK--REQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRT 471
+ + K E ++ +++K R++ M Q E + K + + ++ R+ ++
Sbjct: 485 TWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEK--MQRQEEKMREQEVRLWQ 542
Query: 472 QREHLADRTAEL----ERVNRVNQ 491
Q E + ++ L ER+ ++ Q
Sbjct: 543 QEEKMQEQEVRLQELEERLGKLGQ 566
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 48.9 bits (115), Expect = 1e-05
Identities = 64/326 (19%), Positives = 138/326 (42%), Gaps = 29/326 (8%)
Query: 240 LQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQ--KNAAY 297
L ++++ + ++ +R++E +L+ Q L+ + +++S++ + Q Q +N +
Sbjct: 229 LVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELW 288
Query: 298 NLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQR 357
NL N + E+ + + ++ LK E + +Q + E E K R
Sbjct: 289 NL------LNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIR 342
Query: 358 QYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSE 417
+ + M R E+ +E ++ + ++KM + R D +I+ + + E E
Sbjct: 343 EQEDKMWRQEEKIREQE---EKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE 399
Query: 418 PIFGKNEGELMVEKQKREQNYMKHQLEAAA---NHKRKAILHQLVDQRRDLQMLQRTQRE 474
+ E EK+ REQ+ + E K + + + DQ L+ ++ +E
Sbjct: 400 QEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQE 459
Query: 475 HLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLEDKAFE------RASDKLF-----L 523
+ E++ R + +QE E++ +K E+K +E R +K++ +
Sbjct: 460 EEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKM 519
Query: 524 LDQCEKYRRCKQCQRRTSNVGESNLW 549
+Q EK +R ++ R E LW
Sbjct: 520 QEQEEKMQRQEEKMREQ----EVRLW 541
Score = 40.0 bits (92), Expect = 0.006
Identities = 72/382 (18%), Positives = 166/382 (43%), Gaps = 30/382 (7%)
Query: 123 IELKEMENKLPMETLVEECGENRERKCKLKDQSDKEEGTRDISSPKRLRDR-QALFPAKV 181
+ L+ N + E L E+ E +E K +L + S+K E ++ KR +R Q L P +
Sbjct: 202 LSLELYRNTITDEELKEKNAELQE-KLRLVE-SEKSEIQLNVKDLKRKLERAQLLLPQQQ 259
Query: 182 TNVSL--LEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTSPACQDHNKAGQEMCYVC 239
V L K +S S E + L E K + + ++MC
Sbjct: 260 LQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQE--EKIQEQEEKMCEQE 317
Query: 240 LQRAQRNSLLYYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNL 299
L+ ++ ++ EE+ E ++E++ +Q + QE R Q + + REQ +K
Sbjct: 318 LKIREQEEKMWRQEEKMHE-QEEKIREQEDKMWRQEEKIREQEEKI--REQEEKMWRQEE 374
Query: 300 GVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQY 359
+ E + ++ E ++ + +++ + ++ R+++E + Q
Sbjct: 375 KIREQDEKIQEQEEEMWRQ--------EEKIREQEEKRQEKMWRQEKKMREQDEKIREQE 426
Query: 360 RELMDRLEQVQLTEEL---AAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDS- 415
E+ + E+++ EE+ ++ + +++KM+E + + + +I+ + ++ E +
Sbjct: 427 EEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTW 486
Query: 416 SEPIFGKNEGELMVEKQK--REQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQR 473
+ K E ++ +++K R++ M Q E + K + + ++ R+ ++ Q
Sbjct: 487 RQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEK--MQRQEEKMREQEVRLWQQE 544
Query: 474 EHLADRTAEL----ERVNRVNQ 491
E + ++ L ER+ ++ Q
Sbjct: 545 EKMQEQEVRLQELEERLGKLGQ 566
>gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens]
Length = 1217
Score = 48.9 bits (115), Expect = 1e-05
Identities = 68/311 (21%), Positives = 131/311 (42%), Gaps = 51/311 (16%)
Query: 241 QRAQRNSLLYYSEERRREIEDER-LIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNL 299
+R + N LL Y EER +E+E+ + QYQ + ++ +E N+ A L
Sbjct: 185 KREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEY---TIYNQELNETRA--KL 239
Query: 300 GVAEAIRNHKNEKPEFYKSFLFDK-----------RPLSPALNALKQEEYSRSLLKQMDN 348
A R EK + D R L ++A+K+E+ +Q+
Sbjct: 240 DELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEK------EQLSA 293
Query: 349 RQENEIKQRQYRELMDRLEQVQLTEELAA---QRAKFLKDKMEETQCYKRALDAQIKNKP 405
++ +IKQR EL + L +ELA QR + LK++ + L +I+ K
Sbjct: 294 ERQEQIKQRTKLELKAK----DLQDELAGNSEQRKRLLKERQK--------LLEKIEEKQ 341
Query: 406 SRLPPFEPDSSEPIFGKNEG------------ELMVEKQKREQNYMKHQLEAAANHKRKA 453
L EP + + G +L ++ + Q K + + + K+
Sbjct: 342 KELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKS 401
Query: 454 ILHQLVDQRRDLQMLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAM-KKQRDLEDK 512
+ + D++R + + + + A++ LE+ N+++Q L E R + +K ++++K
Sbjct: 402 LDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNK 461
Query: 513 AFERASDKLFL 523
E S++ +L
Sbjct: 462 KDELQSERNYL 472
>gi|14165274 golgi-associated microtubule-binding protein HOOK3
[Homo sapiens]
Length = 718
Score = 48.9 bits (115), Expect = 1e-05
Identities = 56/285 (19%), Positives = 132/285 (46%), Gaps = 17/285 (5%)
Query: 252 SEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATRE---QNQKNAAYNLG-VAEAIRN 307
SE R++ E L + Q LKD+ + RH ++ E ++ K +LG + ++
Sbjct: 280 SELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKL 339
Query: 308 HKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQR-----QYREL 362
+ + + ++ + + L A A Q E + + ++ NR E K+ +Y+ L
Sbjct: 340 LEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRL 399
Query: 363 MDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIFGK 422
++++ +Q ++ LK+ +EE +C +A + Q+ + +P +SS+ + +
Sbjct: 400 KEKVDSLQKEKDRLRTERDSLKETIEELRCV-QAQEGQLTTQ-GLMPLGSQESSDSLAAE 457
Query: 423 NEGELMVEK--QKREQNYMKHQLEAAANHKRKAILHQLVD----QRRDLQMLQRTQREHL 476
+ EK + + +N M + +++++ A+L L+D ++ +L+ R + L
Sbjct: 458 IVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRL 517
Query: 477 ADRTAELERVNRVNQCLQEDWERSAAMKKQRDLEDKAFERASDKL 521
+ +++E + + Q E S +KK+ + + A+++L
Sbjct: 518 LEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNEL 562
>gi|110347568 centrosomal protein 152kDa [Homo sapiens]
Length = 1654
Score = 48.1 bits (113), Expect = 2e-05
Identities = 81/421 (19%), Positives = 166/421 (39%), Gaps = 64/421 (15%)
Query: 122 RIELKEMENKLP--METLVEECGENRERKCKLKDQSDKEEGTRDISSPKRLRDRQALFPA 179
R EL ++ ++ E +E C E + L+ ++KE+ T++ K ++ + + +
Sbjct: 716 RSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQS 775
Query: 180 KVTNVSLLEKFERSESGGK---IMTPESLSYPSCLKHDSEMKPQTSPACQDHNKAGQEMC 236
K+ K + + G + + T + +S E K C QE
Sbjct: 776 KLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQK------CTIQQNLEQEKD 829
Query: 237 YV---CLQRAQRNSLLYYSEERRREIE------DERLIQQYQMLKDQEALFRHQMKSLAT 287
+++ + L + E +++E +R + + L + +AL + + K
Sbjct: 830 IAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEE 889
Query: 288 REQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMD 347
+ + N + V+EA K+E K+ L K + EE SL K+++
Sbjct: 890 QHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGK----------ELEEKIHSLQKELE 939
Query: 348 NRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEE--------TQCYKRALDA 399
+ E V + ELA R+++ K+K EE Q Y++ LD
Sbjct: 940 LKNEEV--------------PVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDD 985
Query: 400 QIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQKREQNYMKHQLEAAANHKRKAILHQLV 459
+NK + + +++ F K + EL+++K+ Q + + K I ++
Sbjct: 986 H-RNKINEVLA----AAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLEIY 1040
Query: 460 DQRRDL-----QMLQRTQREHLADRTAELERVNRVNQCLQEDWERSAAMKKQRDLEDKAF 514
D+ +L TQ+EH++D +E +++ + W +K + KAF
Sbjct: 1041 QYEEDILTVLGVLLSDTQKEHISD--SEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAF 1098
Query: 515 E 515
+
Sbjct: 1099 Q 1099
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 47.8 bits (112), Expect = 3e-05
Identities = 99/446 (22%), Positives = 176/446 (39%), Gaps = 62/446 (13%)
Query: 123 IELKEMENKLPMETLVEECGENRERKCKLKDQSDKEEGTRDISSPKRLRDRQALFPAKVT 182
I L EME +T+ E+ KLK S E R+I+ K +
Sbjct: 1621 IRLAEME-----QTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQEN 1675
Query: 183 NVSLLEKFERSESGGKIMTPESLSYPSCLKHDSEMKPQTS---PACQDHNKAGQEMCYVC 239
+ ++K + K + +S CLK + + + + + P N + +
Sbjct: 1676 HEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLA 1735
Query: 240 LQRAQRNSLLYYSEERRREIE---DERLI----QQYQMLKDQEALFRHQMKSLATREQNQ 292
L+ Q+ +L E R E+ +ER+I Q+ L Q+ + RH + E
Sbjct: 1736 LKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLN 1795
Query: 293 KNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQEN 352
+N L + EA++ KN + S + L+ L KQ+ Y++ L ++ + QEN
Sbjct: 1796 ENL---LKLKEALKTSKNRE----NSLTDNLNDLNNELQK-KQKAYNKILREKEEIDQEN 1847
Query: 353 EIKQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRL---P 409
+ +RQ + L L+ LT+ + +EE Q + L+ Q++ K + P
Sbjct: 1848 DELKRQIKRLTSGLQGKPLTDN--------KQSLIEELQRKVKKLENQLEGKVEEVDLKP 1899
Query: 410 PFEPDSSEPIFGKNEGELMVEKQKREQNYMKHQ----------------LEAAANHKRKA 453
E ++ E + EG+ K + +N +K + L A A+ ++
Sbjct: 1900 MKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLT 1959
Query: 454 ILHQL------VDQRRDLQMLQ-RTQREHLADRTAELER---VNRVNQCLQEDWERSAAM 503
+ +L VDQ ++ L+ + E L R +LE R +Q L D
Sbjct: 1960 LQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLH 2019
Query: 504 KKQRDLEDKAFERASDKLFLLDQCEK 529
+ R L++K A +K F D K
Sbjct: 2020 LQNRYLQEKL--HALEKQFSKDTYSK 2043
Score = 37.0 bits (84), Expect = 0.048
Identities = 46/231 (19%), Positives = 94/231 (40%), Gaps = 17/231 (7%)
Query: 260 EDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSF 319
E E +++ + +++A F +Q+K+ + +N+ A R +NE + K
Sbjct: 65 EVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQL 124
Query: 320 LFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQR 379
R L L++E+ L + ENE + + + + QL +++ +
Sbjct: 125 EQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQ 184
Query: 380 AKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQKREQNYM 439
+ D +ET +R D+ +++ S+ + I E +E Q +E M
Sbjct: 185 KQI--DSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQE---M 239
Query: 440 KHQLEAAAN---------HKRKAILHQ---LVDQRRDLQMLQRTQREHLAD 478
+ LE + ++ KAI+HQ ++DQ + + Q + L D
Sbjct: 240 RKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTD 290
Score = 36.2 bits (82), Expect = 0.082
Identities = 80/379 (21%), Positives = 159/379 (41%), Gaps = 50/379 (13%)
Query: 154 QSDKEEGTRDISSPKRLRDRQALFPAKVTNVSL-LEKFERSESGGKIMTPESLSYPSCLK 212
+S+K+E + R Q+L K V L LE+ E++ G + E+ +K
Sbjct: 41 KSEKQENVIHL-----FRITQSLMKMKAQEVELALEEVEKA--GEEQAKFENQLKTKVMK 93
Query: 213 HDSEMK-PQTSPACQDHNKAGQEMCYVCLQRAQRNSLLYYSEERRREIEDERLIQQYQML 271
++E++ Q S +D E+C + Q Q++ L E+ +E+E E+ + + L
Sbjct: 94 LENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDREL---EDMEKELEKEKKVNEQLAL 150
Query: 272 KDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPALN 331
+++EA + ++ R +N++ N + + I +++ + ++ L + S +
Sbjct: 151 RNEEA----ENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRS 206
Query: 332 ALKQEEYSRSLLKQMDNRQ----ENEIKQRQYRELMDRLEQ-----VQLTEELAAQRA-- 380
L ++ Y L++ +D Q NE + Q +E+ LE+ ++T+E +A
Sbjct: 207 QLSKKNY--ELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIV 264
Query: 381 -------KFLKDKMEETQCYKRALDAQIKNKPSRLPPF------EPDSSEPIFGKNEGEL 427
LK + + Q + L +K+K P + + + I + E+
Sbjct: 265 HQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEI 324
Query: 428 MVEKQKREQNYMKHQLEAAAN-HKRKAILHQLVDQRRDLQMLQRTQREHLADRTAELERV 486
+E Q+ N + A + K + Q Q RD Q+ T E + T E+E+
Sbjct: 325 -IEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLT--EQVEQYTKEMEK- 380
Query: 487 NRVNQCLQEDWERSAAMKK 505
N C+ ED + K
Sbjct: 381 ---NTCIIEDLKNELQRNK 396
Score = 34.3 bits (77), Expect = 0.31
Identities = 35/160 (21%), Positives = 69/160 (43%), Gaps = 26/160 (16%)
Query: 334 KQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQVQLTEELAAQRAKFLKDKMEETQCY 393
+QEE + +LL + + NE+K + ++ Q ++ AQ + +++E+
Sbjct: 20 RQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEE 79
Query: 394 KRALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMVEKQK---REQNYMKH---QLEAAA 447
+ + Q+K K +L E EL + +Q R+ ++++ QLE
Sbjct: 80 QAKFENQLKTKVMKL---------------ENELEMAQQSAGGRDTRFLRNEICQLEKQL 124
Query: 448 NHKRKAILHQLVDQRRDLQMLQRTQREHLADRTAELERVN 487
K + +L D ++L+ ++ E LA R E E N
Sbjct: 125 EQKDR----ELEDMEKELEK-EKKVNEQLALRNEEAENEN 159
>gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens]
Length = 917
Score = 46.6 bits (109), Expect = 6e-05
Identities = 60/291 (20%), Positives = 122/291 (41%), Gaps = 35/291 (12%)
Query: 250 YYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHK 309
+++ ER R+ L Q+ +++D+ A R ++ ++ + Q +N + + I K
Sbjct: 548 FHTHERERD-----LWQENHLMRDEIARLRLEIDTIKHQNQETENKYF-----KDIEIIK 597
Query: 310 NEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQV 369
+ K+ ++ L+ + YS+ L MD + ++ ++ M RLE
Sbjct: 598 ENNEDLEKTLKRNEETLTKTIT-----RYSKELNVLMDENTMLNSELQKEKQSMSRLETE 652
Query: 370 QLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMV 429
E + A L D ++ Q KR L ++ + + D++ I ++
Sbjct: 653 M--ESYRCRLAAALCDH-DQRQSSKRDLQLAFQSTVNEWCHLQEDTNSHI-------QIL 702
Query: 430 EKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADRTAELERVNRV 489
+Q + LE +++R+A+ + + +L RTQR R ++E + +
Sbjct: 703 SQQLSKAESTSSGLETELHYEREALKEKTLHIEHMQGVLSRTQR-----RLEDIEHMYQN 757
Query: 490 NQCLQEDWERSAAMKKQRDLEDKAFERASDKLFLLDQCEKYRRCKQCQRRT 540
+Q + E + R KQ+ +ED F+ S L QC R+ Q +T
Sbjct: 758 DQPILEKYVR-----KQQSVEDGLFQLQSQNLLYQQQCNDARKKADNQEKT 803
>gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo
sapiens]
Length = 917
Score = 46.6 bits (109), Expect = 6e-05
Identities = 60/291 (20%), Positives = 122/291 (41%), Gaps = 35/291 (12%)
Query: 250 YYSEERRREIEDERLIQQYQMLKDQEALFRHQMKSLATREQNQKNAAYNLGVAEAIRNHK 309
+++ ER R+ L Q+ +++D+ A R ++ ++ + Q +N + + I K
Sbjct: 548 FHTHERERD-----LWQENHLMRDEIARLRLEIDTIKHQNQETENKYF-----KDIEIIK 597
Query: 310 NEKPEFYKSFLFDKRPLSPALNALKQEEYSRSLLKQMDNRQENEIKQRQYRELMDRLEQV 369
+ K+ ++ L+ + YS+ L MD + ++ ++ M RLE
Sbjct: 598 ENNEDLEKTLKRNEETLTKTIT-----RYSKELNVLMDENTMLNSELQKEKQSMSRLETE 652
Query: 370 QLTEELAAQRAKFLKDKMEETQCYKRALDAQIKNKPSRLPPFEPDSSEPIFGKNEGELMV 429
E + A L D ++ Q KR L ++ + + D++ I ++
Sbjct: 653 M--ESYRCRLAAALCDH-DQRQSSKRDLQLAFQSTVNEWCHLQEDTNSHI-------QIL 702
Query: 430 EKQKREQNYMKHQLEAAANHKRKAILHQLVDQRRDLQMLQRTQREHLADRTAELERVNRV 489
+Q + LE +++R+A+ + + +L RTQR R ++E + +
Sbjct: 703 SQQLSKAESTSSGLETELHYEREALKEKTLHIEHMQGVLSRTQR-----RLEDIEHMYQN 757
Query: 490 NQCLQEDWERSAAMKKQRDLEDKAFERASDKLFLLDQCEKYRRCKQCQRRT 540
+Q + E + R KQ+ +ED F+ S L QC R+ Q +T
Sbjct: 758 DQPILEKYVR-----KQQSVEDGLFQLQSQNLLYQQQCNDARKKADNQEKT 803
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.131 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,431,327
Number of Sequences: 37866
Number of extensions: 908230
Number of successful extensions: 5572
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 48
Number of HSP's successfully gapped in prelim test: 455
Number of HSP's that attempted gapping in prelim test: 4287
Number of HSP's gapped (non-prelim): 1376
length of query: 562
length of database: 18,247,518
effective HSP length: 107
effective length of query: 455
effective length of database: 14,195,856
effective search space: 6459114480
effective search space used: 6459114480
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.