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Search of human proteins with 224922801
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD)
isoform 2 [Homo sapiens]
(178 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform... 360 e-100
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 331 2e-91
gi|40254992 carbonic reductase 4 [Homo sapiens] 91 4e-19
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 85 4e-17
gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2 ... 73 1e-13
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [... 73 1e-13
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 69 2e-12
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 69 2e-12
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 69 2e-12
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens] 69 3e-12
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens] 68 5e-12
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens] 67 1e-11
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens] 65 2e-11
gi|25282469 retinol dehydrogenase 10 [Homo sapiens] 65 3e-11
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 65 4e-11
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens] 64 9e-11
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 64 9e-11
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 63 1e-10
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 60 1e-09
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom... 59 2e-09
gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens] 58 4e-09
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 58 4e-09
gi|223646115 short chain dehydrogenase/reductase family 16C, mem... 58 5e-09
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ... 58 5e-09
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 56 2e-08
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 54 5e-08
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 54 5e-08
gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens] 54 5e-08
gi|166795268 retinol dehydrogenase 11 [Homo sapiens] 53 2e-07
gi|22507405 short chain dehydrogenase/reductase family 9C, membe... 52 2e-07
>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
[Homo sapiens]
Length = 178
Score = 360 bits (925), Expect = e-100
Identities = 178/178 (100%), Positives = 178/178 (100%)
Query: 1 MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF 60
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
Sbjct: 1 MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF 60
Query: 61 IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD 120
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
Sbjct: 61 IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD 120
Query: 121 YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAAPTIDCQWIDNTH 178
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAAPTIDCQWIDNTH
Sbjct: 121 YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAAPTIDCQWIDNTH 178
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 331 bits (849), Expect = 2e-91
Identities = 166/166 (100%), Positives = 166/166 (100%)
Query: 1 MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF 60
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
Sbjct: 1 MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF 60
Query: 61 IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD 120
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
Sbjct: 61 IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD 120
Query: 121 YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAA 166
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAA
Sbjct: 121 YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAA 166
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 91.3 bits (225), Expect = 4e-19
Identities = 58/169 (34%), Positives = 89/169 (52%), Gaps = 10/169 (5%)
Query: 6 KVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDV 65
KV V G ++GIGRA A+ + KG ++A++ NLE L L CDV
Sbjct: 3 KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDH-----LAFSCDV 57
Query: 66 ADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLG-----LD 120
A + +++TF ++ H GR++ LVN AG+N + +T ++VS + LG
Sbjct: 58 AKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKA 117
Query: 121 YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAAPTI 169
M +GG I+N+ S+ GL + Q VY ASK G+VGF+R+ A +
Sbjct: 118 AMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEV 166
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 84.7 bits (208), Expect = 4e-17
Identities = 54/171 (31%), Positives = 86/171 (50%), Gaps = 19/171 (11%)
Query: 5 GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCD 64
GKV +VTG +GIG A + GA+V + D + G AL+++ +FI CD
Sbjct: 9 GKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGG----RALEQELPG--AVFILCD 62
Query: 65 VADQQQLRDTFRKVVDHFGRLDILVNNAG---------VNNEKNWEKTLQINLVSVISGT 115
V + ++ + + FGRLD +VNNAG + + + + L++NL+ + T
Sbjct: 63 VTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLT 122
Query: 116 YLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAA 166
L L Y+ K G +IN+SSL G + AQ Y A+K + T++ A
Sbjct: 123 KLALPYLRKSQGN----VINISSLVGAIGQAQAVPYVATKGAVTAMTKALA 169
>gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2
[Homo sapiens]
Length = 252
Score = 73.2 bits (178), Expect = 1e-13
Identities = 53/177 (29%), Positives = 81/177 (45%), Gaps = 22/177 (12%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
V G VA++TG A G+G A AE L+ +GA L+D G L +F
Sbjct: 8 VKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNN-----CVFAP 62
Query: 63 CDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------------NNEKNWEKTLQINL 108
DV ++ ++ FGR+D+ VN AG+ + +++++ L +NL
Sbjct: 63 ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNL 122
Query: 109 VSVISGTYLGLDYMSKQN---GGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFT 162
+ + L M + GG+ G+IIN +S+A Q Y ASK GIVG T
Sbjct: 123 MGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMT 179
>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
[Homo sapiens]
Length = 261
Score = 73.2 bits (178), Expect = 1e-13
Identities = 53/177 (29%), Positives = 81/177 (45%), Gaps = 22/177 (12%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
V G VA++TG A G+G A AE L+ +GA L+D G L +F
Sbjct: 8 VKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNN-----CVFAP 62
Query: 63 CDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------------NNEKNWEKTLQINL 108
DV ++ ++ FGR+D+ VN AG+ + +++++ L +NL
Sbjct: 63 ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNL 122
Query: 109 VSVISGTYLGLDYMSKQN---GGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFT 162
+ + L M + GG+ G+IIN +S+A Q Y ASK GIVG T
Sbjct: 123 MGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMT 179
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 69.3 bits (168), Expect = 2e-12
Identities = 53/170 (31%), Positives = 86/170 (50%), Gaps = 13/170 (7%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
V G++ L+TGA GIGR A +K+ L D N + G++ AA + + F+
Sbjct: 34 VTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDIN-KHGLEETAAKCKGLGAKVHTFV- 91
Query: 63 CDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------NNEKNWEKTLQINLVSVISG 114
D ++++ + + +KV G + ILVNNAGV + EKT ++N+++
Sbjct: 92 VDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWT 151
Query: 115 TYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRS 164
T L M+K N G I+ ++S AG + V YC+SK VGF ++
Sbjct: 152 TKAFLPAMTKNNHGH---IVTVASAAGHVSVPFLLAYCSSKFAAVGFHKT 198
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 69.3 bits (168), Expect = 2e-12
Identities = 55/170 (32%), Positives = 78/170 (45%), Gaps = 15/170 (8%)
Query: 6 KVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDV 65
+VA+VTG+ GIG A A L GA V + + + A L Q E I C V
Sbjct: 37 RVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKL--QGEGLSVAGIVCHV 94
Query: 66 ADQQQLRDTFRKVVDHFGRLDILVNNAGVN---------NEKNWEKTLQINLVSVISGTY 116
+ K ++H G +D LV +AGVN +E+ W+K L +N+ S
Sbjct: 95 GKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLS 154
Query: 117 LGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAA 166
L YM + G +I +SS+A PV VY SK ++G TR+ A
Sbjct: 155 QLLPYMENRRGA----VILVSSIAAYNPVVALGVYNVSKTALLGLTRTLA 200
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 69.3 bits (168), Expect = 2e-12
Identities = 55/170 (32%), Positives = 78/170 (45%), Gaps = 15/170 (8%)
Query: 6 KVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDV 65
+VA+VTG+ GIG A A L GA V + + + A L Q E I C V
Sbjct: 37 RVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKL--QGEGLSVAGIVCHV 94
Query: 66 ADQQQLRDTFRKVVDHFGRLDILVNNAGVN---------NEKNWEKTLQINLVSVISGTY 116
+ K ++H G +D LV +AGVN +E+ W+K L +N+ S
Sbjct: 95 GKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLS 154
Query: 117 LGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAA 166
L YM + G +I +SS+A PV VY SK ++G TR+ A
Sbjct: 155 QLLPYMENRRGA----VILVSSIAAYNPVVALGVYNVSKTALLGLTRTLA 200
>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
Length = 245
Score = 68.6 bits (166), Expect = 3e-12
Identities = 62/178 (34%), Positives = 93/178 (52%), Gaps = 33/178 (18%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
++GKV ++T AAQGIG+A A A +GAKV D N E+ +Q E +K IQ
Sbjct: 4 LDGKVIILTAAAQGIGQAAALAFAREGAKVIATDIN-ESKLQ---------ELEKYPGIQ 53
Query: 63 CDVADQQQLRDTFRKVVDHFG----RLDILVNNAGVNN--------EKNWEKTLQINLVS 110
V D T +K +D F RLD+L N AG + EK+W+ ++ +N+ S
Sbjct: 54 TRVLDV-----TKKKQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRS 108
Query: 111 VISGTYLGLD-YMSKQNGGEGGIIINMSSLA-GLMPVAQQPVYCASKHGIVGFTRSAA 166
+ YL + ++ K + G IINMSS+A + V + VY +K ++G T+S A
Sbjct: 109 M----YLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVA 162
>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
Length = 303
Score = 67.8 bits (164), Expect = 5e-12
Identities = 53/185 (28%), Positives = 85/185 (45%), Gaps = 19/185 (10%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQK---TL 59
+ G+VA+VTG A GIG+A + LL G+ V + LE L P K +
Sbjct: 16 LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
Query: 60 FIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVN--------NEKNWEKTLQINLVSV 111
IQC++ +++++ + + +D FG+++ LVNN G + K W L+ NL
Sbjct: 76 PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGT 135
Query: 112 ISGTYLGLDYMSKQNGGEGGIIIN--MSSLAGLMPVAQQPVYCASKHGIVGFTRSAAPTI 169
Y+ S GG I+N + + AG P+A A++ G+ T+S A
Sbjct: 136 F---YMCKAVYSSWMKEHGGSIVNIIVPTKAG-FPLAVHS--GAARAGVYNLTKSLALEW 189
Query: 170 DCQWI 174
C I
Sbjct: 190 ACSGI 194
>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
Length = 260
Score = 66.6 bits (161), Expect = 1e-11
Identities = 48/171 (28%), Positives = 89/171 (52%), Gaps = 19/171 (11%)
Query: 6 KVALVTGAAQGIGRAFAEALLLKGAKV---ALVDWNL-EAGVQCKAALDEQFEPQKTLFI 61
++ALVTGA+ GIG A A AL+ +G KV A N+ E +CK+A P +
Sbjct: 12 RLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSA----GYPGTLIPY 67
Query: 62 QCDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------NNEKNWEKTLQINLVSVIS 113
+CD+++++ + F + +DI +NNAG+ + W+ +N++++
Sbjct: 68 RCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSI 127
Query: 114 GTYLGLDYMSKQNGGEGGIIINMSSLAG--LMPVAQQPVYCASKHGIVGFT 162
T M ++N +G IIN++S++G ++P++ Y A+K+ + T
Sbjct: 128 CTREAYQSMKERNVDDGH-IININSMSGHRVLPLSVTHFYSATKYAVTALT 177
>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
Length = 261
Score = 65.5 bits (158), Expect = 2e-11
Identities = 56/176 (31%), Positives = 88/176 (50%), Gaps = 20/176 (11%)
Query: 7 VALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAAL----DEQFEPQKT-LFI 61
+ALVTGA GIGRA + L +GA VA D + A + L ++ P+
Sbjct: 13 LALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAF 72
Query: 62 QCDVADQQQLRDTFRKVVDHFGRL-DILVNNAGVN--------NEKNWEKTLQINLVSVI 112
Q DV++ + R +V F R ++V+ AG+ +E +W+K + +NL
Sbjct: 73 QADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNL---- 128
Query: 113 SGTYLGLDYMSKQ--NGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAA 166
GT+L ++ + G G IIN+SS+ G + Q Y ASK G++G T++AA
Sbjct: 129 KGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAA 184
>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
Length = 341
Score = 65.1 bits (157), Expect = 3e-11
Identities = 58/193 (30%), Positives = 87/193 (45%), Gaps = 34/193 (17%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCK---------------A 47
V G+V L+TGA G+GR FA + A + L D N ++ + A
Sbjct: 34 VAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAA 93
Query: 48 AL-----DEQFEPQKTLFI---QCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNN--- 96
AL +E+ P L + CDV ++ + T +V G + +LVNNAGV +
Sbjct: 94 ALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHH 153
Query: 97 -----EKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVY 151
++ E+T+ +N + T L M + N G I+ ++S GL A Y
Sbjct: 154 LLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGH---IVTVASSLGLFSTAGVEDY 210
Query: 152 CASKHGIVGFTRS 164
CASK G+VGF S
Sbjct: 211 CASKFGVVGFHES 223
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 64.7 bits (156), Expect = 4e-11
Identities = 47/165 (28%), Positives = 77/165 (46%), Gaps = 13/165 (7%)
Query: 7 VALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQ--FEPQKTLFIQCD 64
V VTGA+ GIG A L G + L + + K E + + L + D
Sbjct: 52 VVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLD 111
Query: 65 VADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEK--------NWEKTLQINLVSVISGTY 116
+ D + V+ FGR+DILVNN G++ + K +++N + +S T
Sbjct: 112 LTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTK 171
Query: 117 LGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGF 161
L +M ++ G+ I+ ++S+ G++ V YCASKH + GF
Sbjct: 172 CVLPHMIERKQGK---IVTVNSILGIISVPLSIGYCASKHALRGF 213
>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
Length = 736
Score = 63.5 bits (153), Expect = 9e-11
Identities = 52/179 (29%), Positives = 89/179 (49%), Gaps = 17/179 (9%)
Query: 1 MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVD--WNLEAGVQCKAALDEQFEPQKT 58
+ +G+V LVTGA G+GRA+A A +GA V + D + + + A D+ E +
Sbjct: 5 LRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRR 64
Query: 59 LFIQCDVADQQQLRD---TFRKVVDHFGRLDILVNNAGV--------NNEKNWEKTLQIN 107
+ VA+ + + + +D FGR+D++VNNAG+ ++++W+ +++
Sbjct: 65 RGGKA-VANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVH 123
Query: 108 LVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAA 166
L T ++M KQ G II SS +G+ Q Y A+K G++G S A
Sbjct: 124 LRGSFQVTRAAWEHMKKQKYGR---IIMTSSASGIYGNFGQANYSAAKLGLLGLANSLA 179
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 63.5 bits (153), Expect = 9e-11
Identities = 52/165 (31%), Positives = 86/165 (52%), Gaps = 22/165 (13%)
Query: 5 GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCD 64
G+ A+VTG+ GIG+++AE L G KV L+ + + Q + + E+F+ + T I D
Sbjct: 50 GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVE-TRTIAVD 108
Query: 65 VADQQQLRDTFRKVVDHFGRLD--ILVNNAGVNNE------------KNWEKTLQINLVS 110
A + D + K+ L+ ILVNN G++ E +K + IN++S
Sbjct: 109 FASE----DIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILS 164
Query: 111 VISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASK 155
V T L L M +++ G I+N+SS +G++PV +Y A+K
Sbjct: 165 VCKMTQLVLPGMVERS---KGAILNISSGSGMLPVPLLTIYSATK 206
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 63.2 bits (152), Expect = 1e-10
Identities = 54/170 (31%), Positives = 74/170 (43%), Gaps = 14/170 (8%)
Query: 6 KVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDV 65
KVALVT + GIG A A L GA V + + Q A L Q E C V
Sbjct: 33 KVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATL--QGEGLSVTGTVCHV 90
Query: 66 ADQQQLRDTFRKVVDHFGRLDILVNNAGVN---------NEKNWEKTLQINLVSVISGTY 116
+ V G +DILV+NA VN E+ W+KTL IN+ + T
Sbjct: 91 GKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTK 150
Query: 117 LGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAA 166
+ M K+ GG ++ +SS+A P Y SK ++G T++ A
Sbjct: 151 AVVPEMEKRGGGS---VVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLA 197
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 59.7 bits (143), Expect = 1e-09
Identities = 49/172 (28%), Positives = 78/172 (45%), Gaps = 14/172 (8%)
Query: 2 HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQ-CKAALDEQFEPQKTLF 60
+V G++ L+TGA G+GR A G+ + L D N E + CK A + +
Sbjct: 37 NVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMA--REAGATRVHA 94
Query: 61 IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNW--------EKTLQINLVSVI 112
CD + ++ + +V G + IL+NNAG+ K + EK+ +N + +
Sbjct: 95 YTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHL 154
Query: 113 SGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRS 164
TY ++ + G ++ +SS AGL V YCASK GF S
Sbjct: 155 -WTYKA--FLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAES 203
>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
sapiens]
Length = 311
Score = 59.3 bits (142), Expect = 2e-09
Identities = 46/168 (27%), Positives = 80/168 (47%), Gaps = 10/168 (5%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTL--- 59
V KV ++T A G+G+ A GA++ L N E AL +P KT
Sbjct: 35 VQNKVVVITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDALISVADPSKTFTPK 94
Query: 60 FIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEK-TLQINLVSVISGTYLG 118
+ D++D + D ++V+D +G +DIL+NNA V + K +L+++ ++ Y G
Sbjct: 95 LVLLDLSDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELD-KKIMDANYFG 153
Query: 119 LDYMSK-----QNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGF 161
++K G I+ ++++ G + + Y ASKH +GF
Sbjct: 154 PITLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGF 201
>gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
Length = 310
Score = 58.2 bits (139), Expect = 4e-09
Identities = 48/172 (27%), Positives = 80/172 (46%), Gaps = 20/172 (11%)
Query: 5 GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCD 64
G+ A++TGA GIG+A++ L +G V L+ LE ++ A E+ + IQ D
Sbjct: 48 GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEK-LEAIATEIERTTGRSVKIIQAD 106
Query: 65 VADQQQLRDTFRKVVDHFGRLD--ILVNNAG----------VNNEKNWEKTLQINLVSVI 112
D + + + L+ ILVNN G +N + + N+ SV+
Sbjct: 107 FTKD----DIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVV 162
Query: 113 SGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRS 164
T L L +M + + G+I+N+SS L P +Y ASK + F+++
Sbjct: 163 KMTQLILKHMESR---QKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKA 211
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 58.2 bits (139), Expect = 4e-09
Identities = 45/172 (26%), Positives = 79/172 (45%), Gaps = 15/172 (8%)
Query: 2 HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWN---LEAGV-QCKAALDEQFEPQK 57
++ V ++TGA G+G+ A+ GAK+ L N LE + + A+ + + K
Sbjct: 49 YLRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHK 108
Query: 58 TLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNW--------EKTLQINLV 109
+ D+ D + +++ FG +DILVNNAG++ ++ ++ N
Sbjct: 109 PYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYF 168
Query: 110 SVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGF 161
++ T L M K+ G I+ +SS+ G M + + Y ASKH F
Sbjct: 169 GPVALTKALLPSMIKRRQGH---IVAISSIQGKMSIPFRSAYAASKHATQAF 217
>gi|223646115 short chain dehydrogenase/reductase family 16C, member
6 [Homo sapiens]
Length = 323
Score = 57.8 bits (138), Expect = 5e-09
Identities = 49/176 (27%), Positives = 82/176 (46%), Gaps = 15/176 (8%)
Query: 2 HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQ-CKAALDEQFEPQKTLF 60
+V G++ L TGA G+GR A GA + L D N E ++ C+ A ++ +K
Sbjct: 33 NVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEK--GGKKVFP 90
Query: 61 IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNW--------EKTLQINLVSVI 112
CD +++Q++ +V FG + ILVNNA + K + EK+ +N ++
Sbjct: 91 YTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHF 150
Query: 113 SGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQ----PVYCASKHGIVGFTRS 164
L + K N G I +++ + G+ ++ + P Y ASK GF S
Sbjct: 151 WTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAES 206
>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
[Homo sapiens]
Length = 232
Score = 57.8 bits (138), Expect = 5e-09
Identities = 52/173 (30%), Positives = 72/173 (41%), Gaps = 14/173 (8%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
+ KVALVT + GIG A A L A V + + Q A L Q E
Sbjct: 30 LTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATL--QGEGLSVTGTV 87
Query: 63 CDVADQQQLRDTFRKVVDHFGRLDILVNNAGVN---------NEKNWEKTLQINLVSVIS 113
C V + V G +DILV+NA VN E+ W+KTL IN+ +
Sbjct: 88 CHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPAL 147
Query: 114 GTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAA 166
T + M K+ GG ++ +SS+A P Y SK ++G + A
Sbjct: 148 MTKAVVPEMEKRGGGS---VVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLA 197
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 55.8 bits (133), Expect = 2e-08
Identities = 53/183 (28%), Positives = 80/183 (43%), Gaps = 28/183 (15%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
+ GK +VTGA GIG+ A L +G + L ++E +C+AA + +
Sbjct: 36 IPGKTVIVTGANTGIGKQTALELARRGGNIILACRDME---KCEAAAKDIRGETLNHHVN 92
Query: 63 C---DVADQQQLRDTFRKVVDHFGRLDILVNNAGV------NNEKNWEKTLQINLVSVIS 113
D+A + +R+ K+++ R+DIL+NNAGV E +E +N +
Sbjct: 93 ARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLGHFL 152
Query: 114 GTYLGLDYMSKQNGGEGGIIINMSSLAGL-------------MPVAQQPVYCASKHGIVG 160
T L LD K IIN+SSLA + + YC SK IV
Sbjct: 153 LTNLLLD---KLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVL 209
Query: 161 FTR 163
FT+
Sbjct: 210 FTK 212
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 54.3 bits (129), Expect = 5e-08
Identities = 48/168 (28%), Positives = 76/168 (45%), Gaps = 8/168 (4%)
Query: 5 GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQF--EPQKTLFIQ 62
G +VTG + GIG+ A +GA + LV N + +Q K ++ + Q L I
Sbjct: 32 GAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCIS 91
Query: 63 CDVA-DQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDY 121
DV+ D Q+ + ++ + G +D+LVN AG+ +E ++S YLG Y
Sbjct: 92 VDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVY 151
Query: 122 MSK-----QNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRS 164
S+ G I+ +SS AG + + Y ASK I G +
Sbjct: 152 PSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEA 199
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 54.3 bits (129), Expect = 5e-08
Identities = 45/169 (26%), Positives = 80/169 (47%), Gaps = 13/169 (7%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
V G++ L+TGA GIGR + + + L D N + GV+ AA + ++
Sbjct: 34 VAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDIN-KRGVEETAAECRKLGVTAHAYV- 91
Query: 63 CDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------NNEKNWEKTLQINLVSVISG 114
D ++++++ + +V G + I+VNNAG ++ KT ++N++
Sbjct: 92 VDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWI 151
Query: 115 TYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTR 163
T L M ++N G I+ ++S+ G + YC+SK VGF R
Sbjct: 152 TKALLPSMMERNHGH---IVTVASVCGHEGIPYLIPYCSSKFAAVGFHR 197
>gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]
Length = 418
Score = 54.3 bits (129), Expect = 5e-08
Identities = 50/169 (29%), Positives = 72/169 (42%), Gaps = 18/169 (10%)
Query: 5 GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEA-----GVQCKAALDEQFEPQKTL 59
G +TGA++GIG+A A GA + + + G AA + + K L
Sbjct: 10 GCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIEAVGGKAL 69
Query: 60 FIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAG----VNNEKNWEKTLQINLVSVISGT 115
DV D+QQ+ K + FG +DILVNNA N K L + + GT
Sbjct: 70 PCIVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDLMMNVNTRGT 129
Query: 116 YLG----LDYMSKQNGGEGGIIINMSSLAGLMPV--AQQPVYCASKHGI 158
YL + Y+ K I+N+S L PV Q Y +K+G+
Sbjct: 130 YLASKACIPYLKKSKVAH---ILNISPPLNLNPVWFKQHCAYTIAKYGM 175
>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
Length = 318
Score = 52.8 bits (125), Expect = 2e-07
Identities = 41/142 (28%), Positives = 69/142 (48%), Gaps = 9/142 (6%)
Query: 5 GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCD 64
GKV +VTGA GIG+ A+ L +GA+V L ++E G + Q+ L + D
Sbjct: 41 GKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLD 100
Query: 65 VADQQQLRDTFRKVVDHFGRLDILVNNAGV------NNEKNWEKTLQINLVSVISGTYLG 118
++D + +R + + L +L+NNAGV +E + +N + T+L
Sbjct: 101 LSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLL 160
Query: 119 LDYMSKQNGGEGGIIINMSSLA 140
L+ + + I+N+SSLA
Sbjct: 161 LEKLKESAPSR---IVNVSSLA 179
>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
[Homo sapiens]
Length = 313
Score = 52.4 bits (124), Expect = 2e-07
Identities = 52/174 (29%), Positives = 78/174 (44%), Gaps = 21/174 (12%)
Query: 2 HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFI 61
+++ K +TG G G A+ L+ +G +V L E G Q K D + Q TL
Sbjct: 22 NLSEKYVFITGCDSGFGNLLAKQLVDRGMQV-LAACFTEEGSQ-KLQRDTSYRLQTTLL- 78
Query: 62 QCDVADQQQLRDTFRKVVDHFGR--LDILVNNAGVN---------NEKNWEKTLQINLVS 110
DV + ++ + V D G L LVNNAGV + ++ K + +NLV
Sbjct: 79 --DVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVG 136
Query: 111 VISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRS 164
+I T L + + G ++NMSS G + V YC SK G+ F+ S
Sbjct: 137 LIEVTLHMLPMVKRARGR----VVNMSSSGGRVAVIGGG-YCVSKFGVEAFSDS 185
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,997,520
Number of Sequences: 37866
Number of extensions: 229059
Number of successful extensions: 617
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 55
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 495
Number of HSP's gapped (non-prelim): 75
length of query: 178
length of database: 18,247,518
effective HSP length: 96
effective length of query: 82
effective length of database: 14,612,382
effective search space: 1198215324
effective search space used: 1198215324
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.