Search of human proteins with 222136688

Search of human proteins with 222136688

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|222136688 melanocyte-specific gene 1 isoform 2 [Homo
sapiens]
         (219 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|222136688 melanocyte-specific gene 1 isoform 2 [Homo sapiens]      441   e-124
gi|222136692 melanocyte-specific gene 1 isoform 1 [Homo sapiens]      391   e-109
gi|222136690 melanocyte-specific gene 1 isoform 1 [Homo sapiens]      391   e-109
gi|222136686 melanocyte-specific gene 1 isoform 1 [Homo sapiens]      391   e-109
gi|19923343 Cbp/p300-interacting transactivator, with Glu/Asp-ri...    93   2e-19
gi|19263349 Cbp/p300-interacting transactivator, with Glu/Asp-ri...    74   7e-14
gi|38683860 insulin receptor substrate 2 [Homo sapiens]                41   7e-04
gi|21536409 bridging integrator 1 isoform 5 [Homo sapiens]             39   0.003
gi|21536411 bridging integrator 1 isoform 6 [Homo sapiens]             39   0.003
gi|21536413 bridging integrator 1 isoform 7 [Homo sapiens]             39   0.005
gi|21536404 bridging integrator 1 isoform 3 [Homo sapiens]             39   0.005
gi|89142737 alpha 3 type IV collagen isoform 5 precursor [Homo s...    38   0.006
gi|89142735 alpha 3 type IV collagen isoform 4 precursor [Homo s...    38   0.006
gi|89142733 alpha 3 type IV collagen isoform 2 precursor [Homo s...    38   0.006
gi|89142730 alpha 3 type IV collagen isoform 1 precursor [Homo s...    38   0.006
gi|21536407 bridging integrator 1 isoform 4 [Homo sapiens]             37   0.013
gi|239047795 pleckstrin homology domain containing, family A mem...    36   0.022
gi|26667219 eyes absent 1 isoform c [Homo sapiens]                     36   0.029
gi|55750053 atrophin-1 [Homo sapiens]                                  36   0.029
gi|55750041 atrophin-1 [Homo sapiens]                                  36   0.029
gi|50345997 E1A binding protein p300 [Homo sapiens]                    35   0.038
gi|130502140 NEZHA isoform 2 [Homo sapiens]                            35   0.038
gi|122937255 NEZHA isoform 1 [Homo sapiens]                            35   0.038
gi|155030232 proline, glutamic acid and leucine rich protein 1 [...    35   0.038
gi|171460948 TSC22 domain family, member 1 isoform 1 [Homo sapiens]    35   0.050
gi|122937321 UNC homeobox [Homo sapiens]                               35   0.050
gi|5174711 T-box 1 isoform B [Homo sapiens]                            35   0.065
gi|18104952 T-box 1 isoform C [Homo sapiens]                           35   0.065
gi|18104950 T-box 1 isoform A [Homo sapiens]                           35   0.065
gi|194733742 Wolf-Hirschhorn syndrome candidate 2 protein [Homo ...    35   0.065

>gi|222136688 melanocyte-specific gene 1 isoform 2 [Homo sapiens]
          Length = 219

 Score =  441 bits (1134), Expect = e-124
 Identities = 219/219 (100%), Positives = 219/219 (100%)

Query: 1   MEPSAQQLQLAASLPANLSNFCQGSEMPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNL 60
           MEPSAQQLQLAASLPANLSNFCQGSEMPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNL
Sbjct: 1   MEPSAQQLQLAASLPANLSNFCQGSEMPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNL 60

Query: 61  AVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLAS 120
           AVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLAS
Sbjct: 61  AVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLAS 120

Query: 121 MHLQKLNSQYQGMAAATPGQPGEAGPLQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVD 180
           MHLQKLNSQYQGMAAATPGQPGEAGPLQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVD
Sbjct: 121 MHLQKLNSQYQGMAAATPGQPGEAGPLQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVD 180

Query: 181 EEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSSC 219
           EEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSSC
Sbjct: 181 EEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSSC 219


>gi|222136692 melanocyte-specific gene 1 isoform 1 [Homo sapiens]
          Length = 193

 Score =  391 bits (1004), Expect = e-109
 Identities = 193/193 (100%), Positives = 193/193 (100%)

Query: 27  MPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGA 86
           MPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGA
Sbjct: 1   MPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGA 60

Query: 87  PTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATPGQPGEAGP 146
           PTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATPGQPGEAGP
Sbjct: 61  PTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATPGQPGEAGP 120

Query: 147 LQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQ 206
           LQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQ
Sbjct: 121 LQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQ 180

Query: 207 NEFDFTADFPSSC 219
           NEFDFTADFPSSC
Sbjct: 181 NEFDFTADFPSSC 193


>gi|222136690 melanocyte-specific gene 1 isoform 1 [Homo sapiens]
          Length = 193

 Score =  391 bits (1004), Expect = e-109
 Identities = 193/193 (100%), Positives = 193/193 (100%)

Query: 27  MPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGA 86
           MPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGA
Sbjct: 1   MPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGA 60

Query: 87  PTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATPGQPGEAGP 146
           PTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATPGQPGEAGP
Sbjct: 61  PTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATPGQPGEAGP 120

Query: 147 LQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQ 206
           LQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQ
Sbjct: 121 LQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQ 180

Query: 207 NEFDFTADFPSSC 219
           NEFDFTADFPSSC
Sbjct: 181 NEFDFTADFPSSC 193


>gi|222136686 melanocyte-specific gene 1 isoform 1 [Homo sapiens]
          Length = 193

 Score =  391 bits (1004), Expect = e-109
 Identities = 193/193 (100%), Positives = 193/193 (100%)

Query: 27  MPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGA 86
           MPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGA
Sbjct: 1   MPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGA 60

Query: 87  PTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATPGQPGEAGP 146
           PTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATPGQPGEAGP
Sbjct: 61  PTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATPGQPGEAGP 120

Query: 147 LQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQ 206
           LQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQ
Sbjct: 121 LQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQ 180

Query: 207 NEFDFTADFPSSC 219
           NEFDFTADFPSSC
Sbjct: 181 NEFDFTADFPSSC 193


>gi|19923343 Cbp/p300-interacting transactivator, with Glu/Asp-rich
           carboxy-terminal domain, 2 [Homo sapiens]
          Length = 270

 Score = 93.2 bits (230), Expect = 2e-19
 Identities = 60/174 (34%), Positives = 78/174 (44%), Gaps = 35/174 (20%)

Query: 74  PGVASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLL--------------- 118
           P    N ++  G P +S G  + +           FN HP PH                 
Sbjct: 89  PAARFNNSQFMGPPVASQGGSLPASMQLQKLNNQYFNHHPYPHNHYMPDLHPAAGHQMNG 148

Query: 119 ASMHLQKLNSQYQGMAAATPGQPGEAGPLQNWDFGAQAGGAESLSPSAGAQS-------- 170
            + H +  N ++ G  ++TPG  G  G       G+ +GG    S S G           
Sbjct: 149 TNQHFRDCNPKHSG-GSSTPG--GSGGSSTPGGSGSSSGGGAGSSNSGGGSGSGNMPASV 205

Query: 171 ---------PAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQNEFDFTADF 215
                    P +ID+D +DEEVLMSLV+E+GLDR  ELPELWLGQNEFDF  DF
Sbjct: 206 AHVPAAMLPPNVIDTDFIDEEVLMSLVIEMGLDRIKELPELWLGQNEFDFMTDF 259


>gi|19263349 Cbp/p300-interacting transactivator, with Glu/Asp-rich
           carboxy-terminal domain, 4 [Homo sapiens]
          Length = 184

 Score = 74.3 bits (181), Expect = 7e-14
 Identities = 61/171 (35%), Positives = 77/171 (45%), Gaps = 32/171 (18%)

Query: 67  AVAILHYPGVASNGTKASGAPTSSSGSPIGSPTTTPPTKPP------------SFNLHPA 114
           + A  H P         +G    S   P G+P   PP + P            SF   PA
Sbjct: 19  SAAAAHGPHALRTLPPYAGPGLDSGLRPRGAPLGPPPPRQPGALAYGAFGPPSSFQPFPA 78

Query: 115 --PHLLASMHLQKLNSQYQGMAAATPGQPGEAGPLQNWDFGAQAGGAESLSPSAGAQSPA 172
             P      HLQ + + Y G AAA P  PG  GP      G Q       +PSA A  P 
Sbjct: 79  VPPPAAGIAHLQPVATPYPGRAAAPPNAPG--GPP-----GPQP------APSAAAPPPP 125

Query: 173 I-----IDSDPVDEEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSS 218
                 +D++ +DEE L SL +ELGL R  ELPEL+LGQ+EFD  +D  S+
Sbjct: 126 AHALGGMDAELIDEEALTSLELELGLHRVRELPELFLGQSEFDCFSDLGSA 176


>gi|38683860 insulin receptor substrate 2 [Homo sapiens]
          Length = 1338

 Score = 41.2 bits (95), Expect = 7e-04
 Identities = 49/177 (27%), Positives = 65/177 (36%), Gaps = 18/177 (10%)

Query: 2    EPSAQQLQLAASLPANLSNFCQGSEMPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLA 61
            EP A+   L+   P  L++    S + + S PA  +  GT     D+ Q      Y NL 
Sbjct: 926  EPGAR---LSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSDSRQRSPLSDYMNLD 982

Query: 62   VKDRKAVAILHYPGVASNGTKAS--GAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLA 119
                K+      PG  S     S  G  +  + SP   P    P+  PS +L P P   A
Sbjct: 983  FSSPKSPK----PGAPSGHPVGSLDGLLSPEASSPY-PPLPPRPSASPSSSLQPPPPPPA 1037

Query: 120  SMHLQKLNSQYQGMAAATPGQPGEAGPL-----QNWDFGAQAGGAESLSPSAGAQSP 171
               L +L       A AT   PG A  L      N D+   A G  +  P   A  P
Sbjct: 1038 PGELYRLP---PASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVAATPPQPIAAPP 1091


>gi|21536409 bridging integrator 1 isoform 5 [Homo sapiens]
          Length = 518

 Score = 39.3 bits (90), Expect = 0.003
 Identities = 50/220 (22%), Positives = 70/220 (31%), Gaps = 41/220 (18%)

Query: 19  SNFCQGSEMPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVAS 78
           SN       P+ + PA   KG  SP+  D +   +              + + H P  A 
Sbjct: 245 SNTFTVKAQPSDNAPA---KGNKSPSPPDGSPAATP------------EIRVNHEPEPAG 289

Query: 79  NGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNL-----------------------HPAP 115
             T  +  P S S    G P   PP   PS  +                        P  
Sbjct: 290 GATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQPTE 349

Query: 116 HLLASMHLQKLNSQYQGMAAATPGQPGEAGPLQNWDFGAQAGGAESLSPSAGAQSPAIID 175
               S+   + ++     A + P Q  E GP Q  +    AGG +   P+AGAQ P    
Sbjct: 350 SPAGSLPSGEPSAAEGTFAVSWPSQTAEPGPAQPAEASEVAGGTQ---PAAGAQEPGETA 406

Query: 176 SDPVDEEVLMSLVVELGLDRANELPELWLGQNEFDFTADF 215
           +       L ++VVE      N   E   G    D    F
Sbjct: 407 ASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGF 446


>gi|21536411 bridging integrator 1 isoform 6 [Homo sapiens]
          Length = 482

 Score = 38.9 bits (89), Expect = 0.003
 Identities = 48/197 (24%), Positives = 69/197 (35%), Gaps = 31/197 (15%)

Query: 19  SNFCQGSEMPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVAS 78
           SN       P+ + PA   KG  SP+  D +   +              + + H P  A 
Sbjct: 245 SNTFTVKAQPSDNAPA---KGNKSPSPPDGSPAATP------------EIRVNHEPEPAG 289

Query: 79  NGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATP 138
             T  +  P S S    G P   PP   PS  +     +L+       ++    ++  TP
Sbjct: 290 GATPGATLPKSPSQLRKGPPVPPPPKHTPSKEV-KQEQILSLFE----DTFVPEISVTTP 344

Query: 139 GQPGEAGPLQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANE 198
            QP EA  +        AGG +   P+AGAQ P    +       L ++VVE      N 
Sbjct: 345 SQPAEASEV--------AGGTQ---PAAGAQEPGETAASEAASSSLPAVVVETFPATVNG 393

Query: 199 LPELWLGQNEFDFTADF 215
             E   G    D    F
Sbjct: 394 TVEGGSGAGRLDLPPGF 410


>gi|21536413 bridging integrator 1 isoform 7 [Homo sapiens]
          Length = 475

 Score = 38.5 bits (88), Expect = 0.005
 Identities = 48/197 (24%), Positives = 66/197 (33%), Gaps = 38/197 (19%)

Query: 19  SNFCQGSEMPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVAS 78
           SN       P+ + PA   KG  SP+  D +   +              + + H P  A 
Sbjct: 245 SNTFTVKAQPSDNAPA---KGNKSPSPPDGSPAATP------------EIRVNHEPEPAG 289

Query: 79  NGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATP 138
             T  +  P S S  P  SP  + P+  PS                   +     A + P
Sbjct: 290 GATPGATLPKSPS-QPTESPAGSLPSGEPS-------------------AAEGTFAVSWP 329

Query: 139 GQPGEAGPLQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANE 198
            Q  E GP Q  +    AGG +   P+AGAQ P    +       L ++VVE      N 
Sbjct: 330 SQTAEPGPAQPAEASEVAGGTQ---PAAGAQEPGETAASEAASSSLPAVVVETFPATVNG 386

Query: 199 LPELWLGQNEFDFTADF 215
             E   G    D    F
Sbjct: 387 TVEGGSGAGRLDLPPGF 403


>gi|21536404 bridging integrator 1 isoform 3 [Homo sapiens]
          Length = 506

 Score = 38.5 bits (88), Expect = 0.005
 Identities = 48/197 (24%), Positives = 66/197 (33%), Gaps = 38/197 (19%)

Query: 19  SNFCQGSEMPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVAS 78
           SN       P+ + PA   KG  SP+  D +   +              + + H P  A 
Sbjct: 276 SNTFTVKAQPSDNAPA---KGNKSPSPPDGSPAATP------------EIRVNHEPEPAG 320

Query: 79  NGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATP 138
             T  +  P S S  P  SP  + P+  PS                   +     A + P
Sbjct: 321 GATPGATLPKSPS-QPTESPAGSLPSGEPS-------------------AAEGTFAVSWP 360

Query: 139 GQPGEAGPLQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANE 198
            Q  E GP Q  +    AGG +   P+AGAQ P    +       L ++VVE      N 
Sbjct: 361 SQTAEPGPAQPAEASEVAGGTQ---PAAGAQEPGETAASEAASSSLPAVVVETFPATVNG 417

Query: 199 LPELWLGQNEFDFTADF 215
             E   G    D    F
Sbjct: 418 TVEGGSGAGRLDLPPGF 434


>gi|89142737 alpha 3 type IV collagen isoform 5 precursor [Homo
           sapiens]
          Length = 1424

 Score = 38.1 bits (87), Expect = 0.006
 Identities = 26/71 (36%), Positives = 31/71 (43%), Gaps = 12/71 (16%)

Query: 76  VASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAA 135
           +A +G K    P    GSP GSP    P  PP +     P L  +          QG+  
Sbjct: 586 LALSGEKGDQGPPGDPGSP-GSPGPAGPAGPPGYGPQGEPGLQGT----------QGVPG 634

Query: 136 ATPGQPGEAGP 146
           A PG PGEAGP
Sbjct: 635 A-PGPPGEAGP 644


>gi|89142735 alpha 3 type IV collagen isoform 4 precursor [Homo
           sapiens]
          Length = 1494

 Score = 38.1 bits (87), Expect = 0.006
 Identities = 26/71 (36%), Positives = 31/71 (43%), Gaps = 12/71 (16%)

Query: 76  VASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAA 135
           +A +G K    P    GSP GSP    P  PP +     P L  +          QG+  
Sbjct: 586 LALSGEKGDQGPPGDPGSP-GSPGPAGPAGPPGYGPQGEPGLQGT----------QGVPG 634

Query: 136 ATPGQPGEAGP 146
           A PG PGEAGP
Sbjct: 635 A-PGPPGEAGP 644


>gi|89142733 alpha 3 type IV collagen isoform 2 precursor [Homo
           sapiens]
          Length = 1637

 Score = 38.1 bits (87), Expect = 0.006
 Identities = 26/71 (36%), Positives = 31/71 (43%), Gaps = 12/71 (16%)

Query: 76  VASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAA 135
           +A +G K    P    GSP GSP    P  PP +     P L  +          QG+  
Sbjct: 586 LALSGEKGDQGPPGDPGSP-GSPGPAGPAGPPGYGPQGEPGLQGT----------QGVPG 634

Query: 136 ATPGQPGEAGP 146
           A PG PGEAGP
Sbjct: 635 A-PGPPGEAGP 644


>gi|89142730 alpha 3 type IV collagen isoform 1 precursor [Homo
           sapiens]
          Length = 1670

 Score = 38.1 bits (87), Expect = 0.006
 Identities = 26/71 (36%), Positives = 31/71 (43%), Gaps = 12/71 (16%)

Query: 76  VASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAA 135
           +A +G K    P    GSP GSP    P  PP +     P L  +          QG+  
Sbjct: 586 LALSGEKGDQGPPGDPGSP-GSPGPAGPAGPPGYGPQGEPGLQGT----------QGVPG 634

Query: 136 ATPGQPGEAGP 146
           A PG PGEAGP
Sbjct: 635 A-PGPPGEAGP 644


>gi|21536407 bridging integrator 1 isoform 4 [Homo sapiens]
          Length = 497

 Score = 37.0 bits (84), Expect = 0.013
 Identities = 38/148 (25%), Positives = 54/148 (36%), Gaps = 16/148 (10%)

Query: 68  VAILHYPGVASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLN 127
           + + H P  A   T  +  P S S    G P   PP   PS  +     +L+       +
Sbjct: 294 IRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEV-KQEQILSLFE----D 348

Query: 128 SQYQGMAAATPGQPGEAGPLQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMSL 187
           +    ++  TP QP EA  +        AGG +   P+AGAQ P    +       L ++
Sbjct: 349 TFVPEISVTTPSQPAEASEV--------AGGTQ---PAAGAQEPGETAASEAASSSLPAV 397

Query: 188 VVELGLDRANELPELWLGQNEFDFTADF 215
           VVE      N   E   G    D    F
Sbjct: 398 VVETFPATVNGTVEGGSGAGRLDLPPGF 425


>gi|239047795 pleckstrin homology domain containing, family A member
           7 [Homo sapiens]
          Length = 1121

 Score = 36.2 bits (82), Expect = 0.022
 Identities = 34/116 (29%), Positives = 45/116 (38%), Gaps = 16/116 (13%)

Query: 36  DVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPI 95
           DV  G S     AN+E   +   ++   +RK V +  +P V S  T  S  P      P 
Sbjct: 817 DVTAGLS-----ANKENFRILVESVKNPERKTVPLFPHPPVPSLSTSESKPP------PQ 865

Query: 96  GSPTTTPPTKPPSFNLHP-----APHLLASMHLQKLNSQYQGMAAATPGQPGEAGP 146
            SP T+P   P    L P      P+      L+K+ S  Q    A P    EA P
Sbjct: 866 PSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSPTKAKPKVEDEAPP 921


>gi|26667219 eyes absent 1 isoform c [Homo sapiens]
          Length = 557

 Score = 35.8 bits (81), Expect = 0.029
 Identities = 30/99 (30%), Positives = 45/99 (45%), Gaps = 15/99 (15%)

Query: 81  TKASGAPTSSSGSPIGSPTTTP-PT---KPPSF--NLHPAPHLLASMHLQKL-------- 126
           T A G+  + SGS IGS + +P PT    PP    +  P PH+L +   Q +        
Sbjct: 55  TTADGSLNNFSGSAIGSSSFSPRPTHQFSPPQIYPSNRPYPHILPTPSSQTMAAYGQTQF 114

Query: 127 -NSQYQGMAAATPGQPGEAGPLQNWDFGAQAGGAESLSP 164
                Q  A AT  QPG+   + ++    + G ++S SP
Sbjct: 115 TTGMQQATAYATYPQPGQPYGISSYGIKTEGGLSQSQSP 153


>gi|55750053 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 35.8 bits (81), Expect = 0.029
 Identities = 38/166 (22%), Positives = 58/166 (34%), Gaps = 26/166 (15%)

Query: 26  EMPTTSRPA-LDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKAS 84
           E+P    P+ LD   G S   +D + +   +   N     R     ++ PG   N + +S
Sbjct: 95  ELPRPQSPSDLDSLDGRS-LNDDGSSDPRDIDQDN-----RSTSPSIYSPGSVENDSDSS 148

Query: 85  GAPTSSSGSPIGSPTTTPPT--------KPPSFNLHPAPHLLASMHLQKLNSQYQGMAAA 136
              +     P   P   PP+        + P  +  P P +  + +   +      M  A
Sbjct: 149 SGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQA 208

Query: 137 TPGQP---------GEAGPLQNWDFGAQAGGAESL--SPSAGAQSP 171
            PG P         G  G L     G + GGA S    P+ G Q P
Sbjct: 209 PPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHP 254



 Score = 29.3 bits (64), Expect = 2.7
 Identities = 26/104 (25%), Positives = 40/104 (38%), Gaps = 4/104 (3%)

Query: 74  PGVASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAP--HLLASMHLQKLNSQYQ 131
           P V ++    S    + + SP G  T +PP  PP     P+P  +  A+    K  S   
Sbjct: 605 PTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPS 664

Query: 132 GMAAATPGQPGEAGPLQNWDF--GAQAGGAESLSPSAGAQSPAI 173
                 PG  G + P     F  G+   G   L P+  +  P++
Sbjct: 665 FRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSL 708



 Score = 28.9 bits (63), Expect = 3.6
 Identities = 22/66 (33%), Positives = 32/66 (48%), Gaps = 11/66 (16%)

Query: 81  TKASGAPTSSSGSPIGSPTTTP------PTKPPSFNL-HPAPHLLASMHLQKLNSQYQGM 133
           T  S + + +SG+P   P TTP      P+ PP  N  H  P+L     L+ LN+     
Sbjct: 258 TPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNN----A 313

Query: 134 AAATPG 139
           +A+ PG
Sbjct: 314 SASPPG 319


>gi|55750041 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 35.8 bits (81), Expect = 0.029
 Identities = 38/166 (22%), Positives = 58/166 (34%), Gaps = 26/166 (15%)

Query: 26  EMPTTSRPA-LDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKAS 84
           E+P    P+ LD   G S   +D + +   +   N     R     ++ PG   N + +S
Sbjct: 95  ELPRPQSPSDLDSLDGRS-LNDDGSSDPRDIDQDN-----RSTSPSIYSPGSVENDSDSS 148

Query: 85  GAPTSSSGSPIGSPTTTPPT--------KPPSFNLHPAPHLLASMHLQKLNSQYQGMAAA 136
              +     P   P   PP+        + P  +  P P +  + +   +      M  A
Sbjct: 149 SGLSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQA 208

Query: 137 TPGQP---------GEAGPLQNWDFGAQAGGAESL--SPSAGAQSP 171
            PG P         G  G L     G + GGA S    P+ G Q P
Sbjct: 209 PPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHP 254



 Score = 29.3 bits (64), Expect = 2.7
 Identities = 26/104 (25%), Positives = 40/104 (38%), Gaps = 4/104 (3%)

Query: 74  PGVASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAP--HLLASMHLQKLNSQYQ 131
           P V ++    S    + + SP G  T +PP  PP     P+P  +  A+    K  S   
Sbjct: 605 PTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPS 664

Query: 132 GMAAATPGQPGEAGPLQNWDF--GAQAGGAESLSPSAGAQSPAI 173
                 PG  G + P     F  G+   G   L P+  +  P++
Sbjct: 665 FRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSL 708



 Score = 28.9 bits (63), Expect = 3.6
 Identities = 22/66 (33%), Positives = 32/66 (48%), Gaps = 11/66 (16%)

Query: 81  TKASGAPTSSSGSPIGSPTTTP------PTKPPSFNL-HPAPHLLASMHLQKLNSQYQGM 133
           T  S + + +SG+P   P TTP      P+ PP  N  H  P+L     L+ LN+     
Sbjct: 258 TPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNN----A 313

Query: 134 AAATPG 139
           +A+ PG
Sbjct: 314 SASPPG 319


>gi|50345997 E1A binding protein p300 [Homo sapiens]
          Length = 2414

 Score = 35.4 bits (80), Expect = 0.038
 Identities = 41/157 (26%), Positives = 62/157 (39%), Gaps = 24/157 (15%)

Query: 3    PSAQQLQLAASLPANLSNFCQGSEMPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLA- 61
            P  QQLQ     PA +S    G  +    +P L  + G SP K      +S  A  NL  
Sbjct: 2001 PQPQQLQSGMPRPAMMSVAQHGQPLNMAPQPGLG-QVGISPLKPGT---VSQQALQNLLR 2056

Query: 62   --------VKDRKAVAILHY-PGVASNGTKASGAPTSSS---------GSPIGSPTTTPP 103
                    ++ ++ ++ILH  P + +   K   A  ++S         G P G P   PP
Sbjct: 2057 TLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPIPGQPGMPQGQPGLQPP 2116

Query: 104  TKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATPGQ 140
            T P    +H  P  + +M+  +   Q  G+    P Q
Sbjct: 2117 TMPGQQGVHSNP-AMQNMNPMQAGVQRAGLPQQQPQQ 2152



 Score = 27.7 bits (60), Expect = 8.0
 Identities = 17/47 (36%), Positives = 20/47 (42%), Gaps = 3/47 (6%)

Query: 95  IGSPTTTPPTKPP---SFNLHPAPHLLASMHLQKLNSQYQGMAAATP 138
           I +P  TPP  PP   S  LHP P    +    +L  Q Q    A P
Sbjct: 859 IPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAP 905


>gi|130502140 NEZHA isoform 2 [Homo sapiens]
          Length = 1249

 Score = 35.4 bits (80), Expect = 0.038
 Identities = 32/113 (28%), Positives = 44/113 (38%), Gaps = 20/113 (17%)

Query: 77  ASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPH---------------LLASM 121
           A +G    G   +  G   G PT+ P     S +L P PH                L+S+
Sbjct: 656 ADSGPVPGGERPAGEGQ--GEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSL 713

Query: 122 H--LQKLNSQYQGMAAATPGQPGEAGPLQNWDFGAQAGGAESLSPSAGAQSPA 172
              +Q+L  Q Q + A  P  PG A P   W       G ++ SPS   + PA
Sbjct: 714 QRDMQRLTDQQQRLLAP-PEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPA 765


>gi|122937255 NEZHA isoform 1 [Homo sapiens]
          Length = 1276

 Score = 35.4 bits (80), Expect = 0.038
 Identities = 32/113 (28%), Positives = 44/113 (38%), Gaps = 20/113 (17%)

Query: 77  ASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPH---------------LLASM 121
           A +G    G   +  G   G PT+ P     S +L P PH                L+S+
Sbjct: 683 ADSGPVPGGERPAGEGQ--GEPTSRPKAVTFSPDLGPVPHEGLGEYNRAVSKLSAALSSL 740

Query: 122 H--LQKLNSQYQGMAAATPGQPGEAGPLQNWDFGAQAGGAESLSPSAGAQSPA 172
              +Q+L  Q Q + A  P  PG A P   W       G ++ SPS   + PA
Sbjct: 741 QRDMQRLTDQQQRLLAP-PEAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPA 792


>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
            sapiens]
          Length = 1130

 Score = 35.4 bits (80), Expect = 0.038
 Identities = 28/122 (22%), Positives = 43/122 (35%), Gaps = 6/122 (4%)

Query: 80   GTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATPG 139
            GT        +   P   P   PP  PP     P P     + +++  ++ +  A   P 
Sbjct: 966  GTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPT 1025

Query: 140  QPGEAGPLQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANEL 199
               EA P Q           E  SP+AG     +++ +P     L+    E G D+    
Sbjct: 1026 LAPEALPSQG------EVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPP 1079

Query: 200  PE 201
            PE
Sbjct: 1080 PE 1081


>gi|171460948 TSC22 domain family, member 1 isoform 1 [Homo sapiens]
          Length = 1073

 Score = 35.0 bits (79), Expect = 0.050
 Identities = 38/164 (23%), Positives = 64/164 (39%), Gaps = 15/164 (9%)

Query: 51  EMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFN 110
           E ++ A +   +  RK      +P   S    AS    +++G+ +GS  T+    PP   
Sbjct: 6   ESTAAAAAAADISARKMAHPAMFPRRGSGSGSASAL--NAAGTGVGSNATSSEDFPPPSL 63

Query: 111 LHPAPHLLASMH------LQKLNSQYQGMAAATPGQPGEAGPLQNWDFGAQAGGAESLSP 164
           L P P   +S         Q LN   Q    A P  PG     +   F   +     +S 
Sbjct: 64  LQPPPPAASSTSGPQPPPPQSLNLLSQAQLQAQPLAPGGTQMKKKSGFQITSVTPAQISA 123

Query: 165 SAGAQSPAIIDSDPVD-------EEVLMSLVVELGLDRANELPE 201
           S  + +    D++  D       E++  S ++++ L RA +L E
Sbjct: 124 SISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGE 167


>gi|122937321 UNC homeobox [Homo sapiens]
          Length = 531

 Score = 35.0 bits (79), Expect = 0.050
 Identities = 28/89 (31%), Positives = 33/89 (37%), Gaps = 14/89 (15%)

Query: 71  LHYPGVASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQY 130
           LH PG    G     AP+S S S  G  +  PP  PP     P  H           S  
Sbjct: 219 LHSPG----GLSLHSAPSSDSDSGGGGLSPEPPEPPPPAAKGPGAHA----------SGA 264

Query: 131 QGMAAATPGQPGEAGPLQNWDFGAQAGGA 159
            G A A PG+P   G      + +Q  GA
Sbjct: 265 AGTAPAPPGEPPAPGTCDPAFYPSQRSGA 293


>gi|5174711 T-box 1 isoform B [Homo sapiens]
          Length = 372

 Score = 34.7 bits (78), Expect = 0.065
 Identities = 34/135 (25%), Positives = 48/135 (35%), Gaps = 17/135 (12%)

Query: 71  LHYPGVASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQY 130
           +H+  V  +    + +  SS G+  G P    P   P     P P             +Y
Sbjct: 1   MHFSTVTRDMEAFTASSLSSLGAAGGFPGAASPGADPYGPREPPPP----------PPRY 50

Query: 131 QGMAAATPGQPGEAGPLQNWDFGAQAGGAESLS--PSAGAQSPAIIDSDPVDEEVLMSLV 188
              AAA PG PG   P   + F   AG A S +  P     S A     PV +   ++  
Sbjct: 51  DPCAAAAPGAPGPPPPPHAYPFAPAAGAATSAAAEPEGPGASCAAAAKAPVKKNAKVA-- 108

Query: 189 VELGLDRANELPELW 203
              G+    E+  LW
Sbjct: 109 ---GVSVQLEMKALW 120


>gi|18104952 T-box 1 isoform C [Homo sapiens]
          Length = 495

 Score = 34.7 bits (78), Expect = 0.065
 Identities = 34/135 (25%), Positives = 48/135 (35%), Gaps = 17/135 (12%)

Query: 71  LHYPGVASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQY 130
           +H+  V  +    + +  SS G+  G P    P   P     P P             +Y
Sbjct: 1   MHFSTVTRDMEAFTASSLSSLGAAGGFPGAASPGADPYGPREPPPP----------PPRY 50

Query: 131 QGMAAATPGQPGEAGPLQNWDFGAQAGGAESLS--PSAGAQSPAIIDSDPVDEEVLMSLV 188
              AAA PG PG   P   + F   AG A S +  P     S A     PV +   ++  
Sbjct: 51  DPCAAAAPGAPGPPPPPHAYPFAPAAGAATSAAAEPEGPGASCAAAAKAPVKKNAKVA-- 108

Query: 189 VELGLDRANELPELW 203
              G+    E+  LW
Sbjct: 109 ---GVSVQLEMKALW 120


>gi|18104950 T-box 1 isoform A [Homo sapiens]
          Length = 398

 Score = 34.7 bits (78), Expect = 0.065
 Identities = 34/135 (25%), Positives = 48/135 (35%), Gaps = 17/135 (12%)

Query: 71  LHYPGVASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQY 130
           +H+  V  +    + +  SS G+  G P    P   P     P P             +Y
Sbjct: 1   MHFSTVTRDMEAFTASSLSSLGAAGGFPGAASPGADPYGPREPPPP----------PPRY 50

Query: 131 QGMAAATPGQPGEAGPLQNWDFGAQAGGAESLS--PSAGAQSPAIIDSDPVDEEVLMSLV 188
              AAA PG PG   P   + F   AG A S +  P     S A     PV +   ++  
Sbjct: 51  DPCAAAAPGAPGPPPPPHAYPFAPAAGAATSAAAEPEGPGASCAAAAKAPVKKNAKVA-- 108

Query: 189 VELGLDRANELPELW 203
              G+    E+  LW
Sbjct: 109 ---GVSVQLEMKALW 120


>gi|194733742 Wolf-Hirschhorn syndrome candidate 2 protein [Homo
           sapiens]
          Length = 539

 Score = 34.7 bits (78), Expect = 0.065
 Identities = 32/122 (26%), Positives = 52/122 (42%), Gaps = 7/122 (5%)

Query: 32  RPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNG---TKASGAPT 88
           R  LD +    PAKE+   E ++  Y+   V  +K  ++ + P + S     +  S  P 
Sbjct: 286 RKTLDAEVVEKPAKEETVVENATPDYAAGLVSTQKLGSLNNEPALPSTSYLPSTPSVVPA 345

Query: 89  SS---SGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATPGQPGEAG 145
           SS   S     +P++   ++PP     P+P L A    Q+      G++ ATP       
Sbjct: 346 SSYIPSSETPPAPSSREASRPPEEPSAPSPTLPAQFK-QRAPMYNSGLSPATPTPAAPTS 404

Query: 146 PL 147
           PL
Sbjct: 405 PL 406


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.125    0.363 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,239,269
Number of Sequences: 37866
Number of extensions: 550928
Number of successful extensions: 3986
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 238
Number of HSP's that attempted gapping in prelim test: 3563
Number of HSP's gapped (non-prelim): 622
length of query: 219
length of database: 18,247,518
effective HSP length: 98
effective length of query: 121
effective length of database: 14,536,650
effective search space: 1758934650
effective search space used: 1758934650
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.