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Search of human proteins with 222136617
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222136617 myxovirus resistance protein 1 [Homo sapiens]
(662 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222136619 myxovirus resistance protein 1 [Homo sapiens] 1296 0.0
gi|222136617 myxovirus resistance protein 1 [Homo sapiens] 1296 0.0
gi|11342664 myxovirus resistance protein 2 [Homo sapiens] 771 0.0
gi|56549125 dynamin 2 isoform 4 [Homo sapiens] 239 8e-63
gi|56549123 dynamin 2 isoform 2 [Homo sapiens] 239 8e-63
gi|56549121 dynamin 2 isoform 1 [Homo sapiens] 239 8e-63
gi|56549119 dynamin 2 isoform 3 [Homo sapiens] 239 8e-63
gi|56549117 dynamin 1 isoform 2 [Homo sapiens] 238 2e-62
gi|59853099 dynamin 1 isoform 1 [Homo sapiens] 238 2e-62
gi|42544243 dynamin 3 isoform a [Homo sapiens] 230 3e-60
gi|209915561 dynamin 3 isoform b [Homo sapiens] 230 3e-60
gi|171460914 dynamin 1-like isoform 1 [Homo sapiens] 195 1e-49
gi|171460918 dynamin 1-like isoform 3 [Homo sapiens] 195 1e-49
gi|171460916 dynamin 1-like isoform 2 [Homo sapiens] 195 1e-49
gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens] 102 1e-21
gi|224831251 optic atrophy 1 isoform 7 [Homo sapiens] 102 1e-21
gi|18860841 optic atrophy 1 isoform 6 [Homo sapiens] 102 1e-21
gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens] 102 1e-21
gi|18860835 optic atrophy 1 isoform 4 [Homo sapiens] 102 1e-21
gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens] 102 1e-21
gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens] 102 1e-21
gi|224831243 optic atrophy 1 isoform 1 [Homo sapiens] 102 1e-21
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 44 4e-04
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 44 5e-04
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 42 0.002
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 42 0.002
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 42 0.002
gi|4826870 nucleobindin 2 [Homo sapiens] 39 0.020
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 36 0.099
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 36 0.099
>gi|222136619 myxovirus resistance protein 1 [Homo sapiens]
Length = 662
Score = 1296 bits (3354), Expect = 0.0
Identities = 662/662 (100%), Positives = 662/662 (100%)
Query: 1 MVVSEVDIAKADPAAASHPLLLNGDATVAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLR 60
MVVSEVDIAKADPAAASHPLLLNGDATVAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLR
Sbjct: 1 MVVSEVDIAKADPAAASHPLLLNGDATVAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLR 60
Query: 61 ALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKW 120
ALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKW
Sbjct: 61 ALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKW 120
Query: 121 RGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLP 180
RGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLP
Sbjct: 121 RGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLP 180
Query: 181 GITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGD 240
GITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGD
Sbjct: 181 GITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGD 240
Query: 241 RTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREK 300
RTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREK
Sbjct: 241 RTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREK 300
Query: 301 IFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKY 360
IFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKY
Sbjct: 301 IFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKY 360
Query: 361 GVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIEN 420
GVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIEN
Sbjct: 361 GVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIEN 420
Query: 421 NFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMV 480
NFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMV
Sbjct: 421 NFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMV 480
Query: 481 RLAFTDVSIKNFEEFFNLHRTAKSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRG 540
RLAFTDVSIKNFEEFFNLHRTAKSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRG
Sbjct: 481 RLAFTDVSIKNFEEFFNLHRTAKSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRG 540
Query: 541 ALQKVREKELEEEKKKKSWDFGAFQSSSATDSSMEEIFQHLMAYHQEASKRISSHIPLII 600
ALQKVREKELEEEKKKKSWDFGAFQSSSATDSSMEEIFQHLMAYHQEASKRISSHIPLII
Sbjct: 541 ALQKVREKELEEEKKKKSWDFGAFQSSSATDSSMEEIFQHLMAYHQEASKRISSHIPLII 600
Query: 601 QFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDTSDKRKFLKERLARLTQARRRLAQF 660
QFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDTSDKRKFLKERLARLTQARRRLAQF
Sbjct: 601 QFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDTSDKRKFLKERLARLTQARRRLAQF 660
Query: 661 PG 662
PG
Sbjct: 661 PG 662
>gi|222136617 myxovirus resistance protein 1 [Homo sapiens]
Length = 662
Score = 1296 bits (3354), Expect = 0.0
Identities = 662/662 (100%), Positives = 662/662 (100%)
Query: 1 MVVSEVDIAKADPAAASHPLLLNGDATVAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLR 60
MVVSEVDIAKADPAAASHPLLLNGDATVAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLR
Sbjct: 1 MVVSEVDIAKADPAAASHPLLLNGDATVAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLR 60
Query: 61 ALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKW 120
ALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKW
Sbjct: 61 ALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKW 120
Query: 121 RGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLP 180
RGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLP
Sbjct: 121 RGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLP 180
Query: 181 GITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGD 240
GITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGD
Sbjct: 181 GITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGD 240
Query: 241 RTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREK 300
RTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREK
Sbjct: 241 RTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREK 300
Query: 301 IFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKY 360
IFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKY
Sbjct: 301 IFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKY 360
Query: 361 GVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIEN 420
GVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIEN
Sbjct: 361 GVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIEN 420
Query: 421 NFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMV 480
NFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMV
Sbjct: 421 NFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMV 480
Query: 481 RLAFTDVSIKNFEEFFNLHRTAKSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRG 540
RLAFTDVSIKNFEEFFNLHRTAKSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRG
Sbjct: 481 RLAFTDVSIKNFEEFFNLHRTAKSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRG 540
Query: 541 ALQKVREKELEEEKKKKSWDFGAFQSSSATDSSMEEIFQHLMAYHQEASKRISSHIPLII 600
ALQKVREKELEEEKKKKSWDFGAFQSSSATDSSMEEIFQHLMAYHQEASKRISSHIPLII
Sbjct: 541 ALQKVREKELEEEKKKKSWDFGAFQSSSATDSSMEEIFQHLMAYHQEASKRISSHIPLII 600
Query: 601 QFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDTSDKRKFLKERLARLTQARRRLAQF 660
QFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDTSDKRKFLKERLARLTQARRRLAQF
Sbjct: 601 QFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDTSDKRKFLKERLARLTQARRRLAQF 660
Query: 661 PG 662
PG
Sbjct: 661 PG 662
>gi|11342664 myxovirus resistance protein 2 [Homo sapiens]
Length = 715
Score = 771 bits (1992), Expect = 0.0
Identities = 399/626 (63%), Positives = 495/626 (79%), Gaps = 5/626 (0%)
Query: 38 ENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPR 97
ENNL SQYE+KVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPR
Sbjct: 86 ENNLYSQYEQKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPR 145
Query: 98 GSGIVTRCPLVLKLKKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGI 157
GSGIVTRCPLVLKLKK E W G++SY++ E+E+ D +VEKEI+KAQN +AG G GI
Sbjct: 146 GSGIVTRCPLVLKLKKQPCE-AWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGI 204
Query: 158 SHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVV 217
SHELI+LEI+S +VPDLT+IDLPGITRVAV NQP DIG +IK LIKKYIQRQ+TI+LVVV
Sbjct: 205 SHELISLEITSPEVPDLTIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVV 264
Query: 218 PSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMI 277
P NVDIATTEALSMA EVDPEGDRTIGILTKPDL+D+GTE V++VVRNL + LKKGYMI
Sbjct: 265 PCNVDIATTEALSMAHEVDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMI 324
Query: 278 VKCRGQQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICK 337
VKCRGQQEI ++LSL+EA ++E FF+ HPYFR LLEEG ATVP LAE+LT+ELI HI K
Sbjct: 325 VKCRGQQEITNRLSLAEATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQK 384
Query: 338 SLPLLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVG 397
SLPLLE QI+E+HQ+ TEEL++ G DIP E +KMFFLI+K+ FNQDI L++GEE V
Sbjct: 385 SLPLLEGQIRESHQKATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGEEVVR 444
Query: 398 EEDIRLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETI 457
E + RL+ ++R +F W I+ N Q+ I+ +++K+E QYRG+EL GFVNY+TFE I
Sbjct: 445 ENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEII 504
Query: 458 VKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIKNFEEFFNLHRTAKSKIEDIRAEQEREG 517
V Q I+ L EPA+ ML ++++ AF +V+ K+F EFFNL++T +S IEDI+ + +
Sbjct: 505 VHQYIQQLVEPALSMLQKAMEIIQQAFINVAKKHFGEFFNLNQTVQSTIEDIKVKHTAKA 564
Query: 518 EKLIRLHFQMEQIVYCQDQVYRGALQKVREKELEEEKKKKSWDF---GAFQSSSATDSSM 574
E +I+L F+MEQ+V+CQDQ+Y L+KVRE E+ S + F S+ ++ SS
Sbjct: 565 ENMIQLQFRMEQMVFCQDQIYSVVLKKVRE-EIFNPLGTPSQNMKLNSHFPSNESSVSSF 623
Query: 575 EEIFQHLMAYHQEASKRISSHIPLIIQFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERS 634
EI HL AY E SKR+++ IP IIQ+FML+ G LQKAM+Q+LQ+K+ YSWLL+E+S
Sbjct: 624 TEIGIHLNAYFLETSKRLANQIPFIIQYFMLRENGDSLQKAMMQILQEKNRYSWLLQEQS 683
Query: 635 DTSDKRKFLKERLARLTQARRRLAQF 660
+T+ KR+ LKER+ RLTQAR L QF
Sbjct: 684 ETATKRRILKERIYRLTQARHALCQF 709
>gi|56549125 dynamin 2 isoform 4 [Homo sapiens]
Length = 866
Score = 239 bits (609), Expect = 8e-63
Identities = 158/435 (36%), Positives = 245/435 (56%), Gaps = 15/435 (3%)
Query: 47 EKVRPCID-LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVA-LPRGSGIVTR 104
E++ P ++ L D+ ++G L LP IAV+G QS+GKSSVLE G LPRGSGIVTR
Sbjct: 7 EELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTR 66
Query: 105 CPLVLKL--KKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELI 162
PL+L+L K + + K + +D EV +EI + + G GIS I
Sbjct: 67 RPLILQLIFSKTEHAEFLHCKSK------KFTDFDEVRQEIEAETDRVTGTNKGISPVPI 120
Query: 163 TLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVD 222
L + S V +LTLIDLPGIT+V VG+QP DI Y+IK +I ++I R+ ++ L V P+N+D
Sbjct: 121 NLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD 180
Query: 223 IATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRG 282
+A ++AL +A+EVDP+G RTIG++TK DL+D+GT+ + DV+ N + L++GY+ V R
Sbjct: 181 LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDAR--DVLENKLLPLRRGYIGVVNRS 238
Query: 283 QQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLL 342
Q++I+ + + AL E+ FF +HP +R + + + P L + L +L HI +SLP L
Sbjct: 239 QKDIEGKKDIRAALAAERKFFLSHPAYRHMAD--RMGTPHLQKTLNQQLTNHIRESLPAL 296
Query: 343 ENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGE-ETVGEEDI 401
++++ + +E+++Y P+D K L+ V F D ++G + V ++
Sbjct: 297 RSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLEL 356
Query: 402 RLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQ 461
R+ FH+ + K L R+I G F FE IVK+Q
Sbjct: 357 SGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQ 416
Query: 462 IKALEEPAVDMLHTV 476
I L+EP++ + V
Sbjct: 417 IVKLKEPSLKCVDLV 431
>gi|56549123 dynamin 2 isoform 2 [Homo sapiens]
Length = 870
Score = 239 bits (609), Expect = 8e-63
Identities = 158/435 (36%), Positives = 245/435 (56%), Gaps = 15/435 (3%)
Query: 47 EKVRPCID-LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVA-LPRGSGIVTR 104
E++ P ++ L D+ ++G L LP IAV+G QS+GKSSVLE G LPRGSGIVTR
Sbjct: 7 EELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTR 66
Query: 105 CPLVLKL--KKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELI 162
PL+L+L K + + K + +D EV +EI + + G GIS I
Sbjct: 67 RPLILQLIFSKTEHAEFLHCKSK------KFTDFDEVRQEIEAETDRVTGTNKGISPVPI 120
Query: 163 TLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVD 222
L + S V +LTLIDLPGIT+V VG+QP DI Y+IK +I ++I R+ ++ L V P+N+D
Sbjct: 121 NLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD 180
Query: 223 IATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRG 282
+A ++AL +A+EVDP+G RTIG++TK DL+D+GT+ + DV+ N + L++GY+ V R
Sbjct: 181 LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDAR--DVLENKLLPLRRGYIGVVNRS 238
Query: 283 QQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLL 342
Q++I+ + + AL E+ FF +HP +R + + + P L + L +L HI +SLP L
Sbjct: 239 QKDIEGKKDIRAALAAERKFFLSHPAYRHMAD--RMGTPHLQKTLNQQLTNHIRESLPAL 296
Query: 343 ENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGE-ETVGEEDI 401
++++ + +E+++Y P+D K L+ V F D ++G + V ++
Sbjct: 297 RSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLEL 356
Query: 402 RLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQ 461
R+ FH+ + K L R+I G F FE IVK+Q
Sbjct: 357 SGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQ 416
Query: 462 IKALEEPAVDMLHTV 476
I L+EP++ + V
Sbjct: 417 IVKLKEPSLKCVDLV 431
>gi|56549121 dynamin 2 isoform 1 [Homo sapiens]
Length = 870
Score = 239 bits (609), Expect = 8e-63
Identities = 166/477 (34%), Positives = 256/477 (53%), Gaps = 33/477 (6%)
Query: 47 EKVRPCID-LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVA-LPRGSGIVTR 104
E++ P ++ L D+ ++G L LP IAV+G QS+GKSSVLE G LPRGSGIVTR
Sbjct: 7 EELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTR 66
Query: 105 CPLVLKL--KKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELI 162
PL+L+L K + + K + +D EV +EI + + G GIS I
Sbjct: 67 RPLILQLIFSKTEHAEFLHCKSK------KFTDFDEVRQEIEAETDRVTGTNKGISPVPI 120
Query: 163 TLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVD 222
L + S V +LTLIDLPGIT+V VG+QP DI Y+IK +I ++I R+ ++ L V P+N+D
Sbjct: 121 NLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD 180
Query: 223 IATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRG 282
+A ++AL +A+EVDP+G RTIG++TK DL+D+GT+ + DV+ N + L++GY+ V R
Sbjct: 181 LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDAR--DVLENKLLPLRRGYIGVVNRS 238
Query: 283 QQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLL 342
Q++I+ + + AL E+ FF +HP +R + + + P L + L +L HI +SLP L
Sbjct: 239 QKDIEGKKDIRAALAAERKFFLSHPAYRHMAD--RMGTPHLQKTLNQQLTNHIRESLPAL 296
Query: 343 ENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGE-ETVGEEDI 401
++++ + +E+++Y P+D K L+ V F D ++G + V ++
Sbjct: 297 RSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLEL 356
Query: 402 RLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQ 461
R+ FH+ + K L R+I G F FE IVK+Q
Sbjct: 357 SGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQ 416
Query: 462 IKALEEPAVDMLHTVTDMVRLAFTDVSIKNFEEFFNLHRTAKSKIED---IRAEQER 515
+ L+EP + + V +E N R SK+ +R E ER
Sbjct: 417 VVKLKEPCLKCVDLV---------------IQELINTVRQCTSKLSSYPRLREETER 458
>gi|56549119 dynamin 2 isoform 3 [Homo sapiens]
Length = 866
Score = 239 bits (609), Expect = 8e-63
Identities = 166/477 (34%), Positives = 256/477 (53%), Gaps = 33/477 (6%)
Query: 47 EKVRPCID-LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVA-LPRGSGIVTR 104
E++ P ++ L D+ ++G L LP IAV+G QS+GKSSVLE G LPRGSGIVTR
Sbjct: 7 EELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTR 66
Query: 105 CPLVLKL--KKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELI 162
PL+L+L K + + K + +D EV +EI + + G GIS I
Sbjct: 67 RPLILQLIFSKTEHAEFLHCKSK------KFTDFDEVRQEIEAETDRVTGTNKGISPVPI 120
Query: 163 TLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVD 222
L + S V +LTLIDLPGIT+V VG+QP DI Y+IK +I ++I R+ ++ L V P+N+D
Sbjct: 121 NLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD 180
Query: 223 IATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRG 282
+A ++AL +A+EVDP+G RTIG++TK DL+D+GT+ + DV+ N + L++GY+ V R
Sbjct: 181 LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDAR--DVLENKLLPLRRGYIGVVNRS 238
Query: 283 QQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLL 342
Q++I+ + + AL E+ FF +HP +R + + + P L + L +L HI +SLP L
Sbjct: 239 QKDIEGKKDIRAALAAERKFFLSHPAYRHMAD--RMGTPHLQKTLNQQLTNHIRESLPAL 296
Query: 343 ENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGE-ETVGEEDI 401
++++ + +E+++Y P+D K L+ V F D ++G + V ++
Sbjct: 297 RSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLEL 356
Query: 402 RLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQ 461
R+ FH+ + K L R+I G F FE IVK+Q
Sbjct: 357 SGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQ 416
Query: 462 IKALEEPAVDMLHTVTDMVRLAFTDVSIKNFEEFFNLHRTAKSKIED---IRAEQER 515
+ L+EP + + V +E N R SK+ +R E ER
Sbjct: 417 VVKLKEPCLKCVDLV---------------IQELINTVRQCTSKLSSYPRLREETER 458
>gi|56549117 dynamin 1 isoform 2 [Homo sapiens]
Length = 851
Score = 238 bits (606), Expect = 2e-62
Identities = 156/428 (36%), Positives = 237/428 (55%), Gaps = 21/428 (4%)
Query: 55 LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVA-LPRGSGIVTRCPLVLKLKK 113
L D+ A+G DL LP IAV+G QS+GKSSVLE G LPRGSGIVTR PLVL+L
Sbjct: 16 LQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVN 75
Query: 114 LVNEDK----WRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSR 169
E +GK + +D EV EI + + G GIS I L + S
Sbjct: 76 ATTEYAEFLHCKGK--------KFTDFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSP 127
Query: 170 DVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEAL 229
V +LTL+DLPG+T+V VG+QP DI ++I+ ++ +++ ++ + L V P+N D+A ++AL
Sbjct: 128 HVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDAL 187
Query: 230 SMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQ 289
+A+EVDP+G RTIG++TK DL+D+GT+ + DV+ N + L++GY+ V R Q++I +
Sbjct: 188 KVAKEVDPQGQRTIGVITKLDLMDEGTDAR--DVLENKLLPLRRGYIGVVNRSQKDIDGK 245
Query: 290 LSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKET 349
++ AL E+ FF +HP +R L + + P L + L +L HI +LP L N+++
Sbjct: 246 KDITAALAAERKFFLSHPSYRHLAD--RMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQ 303
Query: 350 HQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGE-ETVGEEDIRLFTRLR 408
I +E+++Y P+D K L+ V F D ++G + + ++ R+
Sbjct: 304 LLSIEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARIN 363
Query: 409 HEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEP 468
FH+ + K L R+I G F FETIVK+Q+K + EP
Sbjct: 364 RIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKIREP 423
Query: 469 ---AVDML 473
VDM+
Sbjct: 424 CLKCVDMV 431
>gi|59853099 dynamin 1 isoform 1 [Homo sapiens]
Length = 864
Score = 238 bits (606), Expect = 2e-62
Identities = 156/428 (36%), Positives = 237/428 (55%), Gaps = 21/428 (4%)
Query: 55 LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVA-LPRGSGIVTRCPLVLKLKK 113
L D+ A+G DL LP IAV+G QS+GKSSVLE G LPRGSGIVTR PLVL+L
Sbjct: 16 LQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVN 75
Query: 114 LVNEDK----WRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSR 169
E +GK + +D EV EI + + G GIS I L + S
Sbjct: 76 ATTEYAEFLHCKGK--------KFTDFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSP 127
Query: 170 DVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEAL 229
V +LTL+DLPG+T+V VG+QP DI ++I+ ++ +++ ++ + L V P+N D+A ++AL
Sbjct: 128 HVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDAL 187
Query: 230 SMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQ 289
+A+EVDP+G RTIG++TK DL+D+GT+ + DV+ N + L++GY+ V R Q++I +
Sbjct: 188 KVAKEVDPQGQRTIGVITKLDLMDEGTDAR--DVLENKLLPLRRGYIGVVNRSQKDIDGK 245
Query: 290 LSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKET 349
++ AL E+ FF +HP +R L + + P L + L +L HI +LP L N+++
Sbjct: 246 KDITAALAAERKFFLSHPSYRHLAD--RMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQ 303
Query: 350 HQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGE-ETVGEEDIRLFTRLR 408
I +E+++Y P+D K L+ V F D ++G + + ++ R+
Sbjct: 304 LLSIEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARIN 363
Query: 409 HEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEP 468
FH+ + K L R+I G F FETIVK+Q+K + EP
Sbjct: 364 RIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKIREP 423
Query: 469 ---AVDML 473
VDM+
Sbjct: 424 CLKCVDMV 431
>gi|42544243 dynamin 3 isoform a [Homo sapiens]
Length = 863
Score = 230 bits (587), Expect = 3e-60
Identities = 161/439 (36%), Positives = 240/439 (54%), Gaps = 23/439 (5%)
Query: 47 EKVRPCID-LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSG-VALPRGSGIVTR 104
E++ P ++ L D+ ALG L LP IAV+G QS+GKSSVLE G LPRGSGIVTR
Sbjct: 7 EELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTR 66
Query: 105 CPLVLKLKKLVNEDKWRGKVSYQDY----EIEISDASEVEKEINKAQNAIAGEGMGISHE 160
PLVL+L K Y ++ + +D EV EI + + G GIS
Sbjct: 67 RPLVLQLV--------TSKAEYAEFLHCKGKKFTDFDEVRLEIEAETDRVTGMNKGISSI 118
Query: 161 LITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSN 220
I L + S V +LTLIDLPGIT+V VG+QP DI Y+I+ +I ++I R+ + L V P+N
Sbjct: 119 PINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPAN 178
Query: 221 VDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKC 280
D+A ++AL +A+EVDP+G RTIG++TK DL+D+GT+ + DV+ N + L++GY+ V
Sbjct: 179 TDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDAR--DVLENKLLPLRRGYVGVVN 236
Query: 281 RGQQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLP 340
R Q++I + + A+ E+ FF +HP +R + + + P L + L +L HI +LP
Sbjct: 237 RSQKDIDGKKDIKAAMLAERKFFLSHPAYRHIAD--RMGTPHLQKVLNQQLTNHIRDTLP 294
Query: 341 LLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGE-ETVGEE 399
N+++ I E++ Y PED K L+ V F D ++G + V
Sbjct: 295 NFRNKLQGQLLSIEHEVEAYKNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVDTL 354
Query: 400 DIRLFTRLRHEFHKW--STIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETI 457
++ ++ FH+ I++ F E K L R+I G F FE I
Sbjct: 355 ELSGGAKINRIFHERFPFEIVKMEFNE--KELRREISYAIKNIHGIRTGLFTPDMAFEAI 412
Query: 458 VKQQIKALEEPAVDMLHTV 476
VK+QI L+ P++ + V
Sbjct: 413 VKKQIVKLKGPSLKSVDLV 431
>gi|209915561 dynamin 3 isoform b [Homo sapiens]
Length = 859
Score = 230 bits (587), Expect = 3e-60
Identities = 161/439 (36%), Positives = 240/439 (54%), Gaps = 23/439 (5%)
Query: 47 EKVRPCID-LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSG-VALPRGSGIVTR 104
E++ P ++ L D+ ALG L LP IAV+G QS+GKSSVLE G LPRGSGIVTR
Sbjct: 7 EELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTR 66
Query: 105 CPLVLKLKKLVNEDKWRGKVSYQDY----EIEISDASEVEKEINKAQNAIAGEGMGISHE 160
PLVL+L K Y ++ + +D EV EI + + G GIS
Sbjct: 67 RPLVLQLV--------TSKAEYAEFLHCKGKKFTDFDEVRLEIEAETDRVTGMNKGISSI 118
Query: 161 LITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSN 220
I L + S V +LTLIDLPGIT+V VG+QP DI Y+I+ +I ++I R+ + L V P+N
Sbjct: 119 PINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPAN 178
Query: 221 VDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKC 280
D+A ++AL +A+EVDP+G RTIG++TK DL+D+GT+ + DV+ N + L++GY+ V
Sbjct: 179 TDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDAR--DVLENKLLPLRRGYVGVVN 236
Query: 281 RGQQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLP 340
R Q++I + + A+ E+ FF +HP +R + + + P L + L +L HI +LP
Sbjct: 237 RSQKDIDGKKDIKAAMLAERKFFLSHPAYRHIAD--RMGTPHLQKVLNQQLTNHIRDTLP 294
Query: 341 LLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGE-ETVGEE 399
N+++ I E++ Y PED K L+ V F D ++G + V
Sbjct: 295 NFRNKLQGQLLSIEHEVEAYKNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVDTL 354
Query: 400 DIRLFTRLRHEFHKW--STIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETI 457
++ ++ FH+ I++ F E K L R+I G F FE I
Sbjct: 355 ELSGGAKINRIFHERFPFEIVKMEFNE--KELRREISYAIKNIHGIRTGLFTPDMAFEAI 412
Query: 458 VKQQIKALEEPAVDMLHTV 476
VK+QI L+ P++ + V
Sbjct: 413 VKKQIVKLKGPSLKSVDLV 431
>gi|171460914 dynamin 1-like isoform 1 [Homo sapiens]
Length = 736
Score = 195 bits (495), Expect = 1e-49
Identities = 149/451 (33%), Positives = 236/451 (52%), Gaps = 31/451 (6%)
Query: 68 LALPAIAVIGDQSSGKSSVLEALSGV-ALPRGSGIVTRCPLVLKLKKLVNEDKWRGKVSY 126
+ LP I V+G QSSGKSSVLE+L G LPRG+GIVTR PL+L+L + EDK +
Sbjct: 23 IQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRKTTGEE 82
Query: 127 QDYEIE------------ISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDL 174
E E +D E+ +EI I+G G+S E I L+I S +V +L
Sbjct: 83 NGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVVNL 142
Query: 175 TLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQE 234
TL+DLPG+T+V VG+QP DI +I+ LI ++I +I L V +N D+AT+EAL +++E
Sbjct: 143 TLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISRE 202
Query: 235 VDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSE 294
VDP+G RT+ ++TK DL+D GT+ +DV+ V +K G + V R Q +I ++ S+++
Sbjct: 203 VDPDGRRTLAVITKLDLMDAGTD--AMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTD 260
Query: 295 ALQREKIFFEN-HPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRI 353
+++ E F + +P + + LA L L+ HI LP L+ +I +
Sbjct: 261 SIRDEYAFLQKKYPSLAN-----RNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQY 315
Query: 354 TEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGE-ETVGEEDIRLFTRLRHEFH 412
L YG E ++K L+ + F + ++G + + ++ R+ + FH
Sbjct: 316 QSLLNSYG----EPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFH 371
Query: 413 K-WSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPA-- 469
+ + +E+ G + N G FV +FE +VK+QIK LEEP+
Sbjct: 372 ETFGRTLESVDPLGGLNTIDILTAIRNA-TGPRPALFVPEVSFELLVKRQIKRLEEPSLR 430
Query: 470 -VDMLHTVTDMVRLAFTDVSIKNFEEFFNLH 499
V+++H + ++ S + F LH
Sbjct: 431 CVELVHEEMQRIIQHCSNYSTQELLRFPKLH 461
>gi|171460918 dynamin 1-like isoform 3 [Homo sapiens]
Length = 699
Score = 195 bits (495), Expect = 1e-49
Identities = 149/451 (33%), Positives = 236/451 (52%), Gaps = 31/451 (6%)
Query: 68 LALPAIAVIGDQSSGKSSVLEALSGV-ALPRGSGIVTRCPLVLKLKKLVNEDKWRGKVSY 126
+ LP I V+G QSSGKSSVLE+L G LPRG+GIVTR PL+L+L + EDK +
Sbjct: 23 IQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRKTTGEE 82
Query: 127 QDYEIE------------ISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDL 174
E E +D E+ +EI I+G G+S E I L+I S +V +L
Sbjct: 83 NGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVVNL 142
Query: 175 TLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQE 234
TL+DLPG+T+V VG+QP DI +I+ LI ++I +I L V +N D+AT+EAL +++E
Sbjct: 143 TLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISRE 202
Query: 235 VDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSE 294
VDP+G RT+ ++TK DL+D GT+ +DV+ V +K G + V R Q +I ++ S+++
Sbjct: 203 VDPDGRRTLAVITKLDLMDAGTD--AMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTD 260
Query: 295 ALQREKIFFEN-HPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRI 353
+++ E F + +P + + LA L L+ HI LP L+ +I +
Sbjct: 261 SIRDEYAFLQKKYPSLAN-----RNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQY 315
Query: 354 TEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGE-ETVGEEDIRLFTRLRHEFH 412
L YG E ++K L+ + F + ++G + + ++ R+ + FH
Sbjct: 316 QSLLNSYG----EPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFH 371
Query: 413 K-WSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPA-- 469
+ + +E+ G + N G FV +FE +VK+QIK LEEP+
Sbjct: 372 ETFGRTLESVDPLGGLNTIDILTAIRNA-TGPRPALFVPEVSFELLVKRQIKRLEEPSLR 430
Query: 470 -VDMLHTVTDMVRLAFTDVSIKNFEEFFNLH 499
V+++H + ++ S + F LH
Sbjct: 431 CVELVHEEMQRIIQHCSNYSTQELLRFPKLH 461
>gi|171460916 dynamin 1-like isoform 2 [Homo sapiens]
Length = 710
Score = 195 bits (495), Expect = 1e-49
Identities = 149/451 (33%), Positives = 236/451 (52%), Gaps = 31/451 (6%)
Query: 68 LALPAIAVIGDQSSGKSSVLEALSGV-ALPRGSGIVTRCPLVLKLKKLVNEDKWRGKVSY 126
+ LP I V+G QSSGKSSVLE+L G LPRG+GIVTR PL+L+L + EDK +
Sbjct: 23 IQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRKTTGEE 82
Query: 127 QDYEIE------------ISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDL 174
E E +D E+ +EI I+G G+S E I L+I S +V +L
Sbjct: 83 NGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVVNL 142
Query: 175 TLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQE 234
TL+DLPG+T+V VG+QP DI +I+ LI ++I +I L V +N D+AT+EAL +++E
Sbjct: 143 TLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISRE 202
Query: 235 VDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSE 294
VDP+G RT+ ++TK DL+D GT+ +DV+ V +K G + V R Q +I ++ S+++
Sbjct: 203 VDPDGRRTLAVITKLDLMDAGTD--AMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTD 260
Query: 295 ALQREKIFFEN-HPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRI 353
+++ E F + +P + + LA L L+ HI LP L+ +I +
Sbjct: 261 SIRDEYAFLQKKYPSLAN-----RNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQY 315
Query: 354 TEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGE-ETVGEEDIRLFTRLRHEFH 412
L YG E ++K L+ + F + ++G + + ++ R+ + FH
Sbjct: 316 QSLLNSYG----EPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFH 371
Query: 413 K-WSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPA-- 469
+ + +E+ G + N G FV +FE +VK+QIK LEEP+
Sbjct: 372 ETFGRTLESVDPLGGLNTIDILTAIRNA-TGPRPALFVPEVSFELLVKRQIKRLEEPSLR 430
Query: 470 -VDMLHTVTDMVRLAFTDVSIKNFEEFFNLH 499
V+++H + ++ S + F LH
Sbjct: 431 CVELVHEEMQRIIQHCSNYSTQELLRFPKLH 461
>gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens]
Length = 1015
Score = 102 bits (253), Expect = 1e-21
Identities = 113/478 (23%), Positives = 210/478 (43%), Gaps = 29/478 (6%)
Query: 28 VAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVL 87
V QK+ + L + +D++ A QD LP + V+GDQS+GK+SVL
Sbjct: 302 VLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQD-HLPRVVVVGDQSAGKTSVL 360
Query: 88 EALSGVAL-PRGSG-IVTRCPLVLKLKKLVNEDKWRGKVSYQDYEI-EISDASEVEKEIN 144
E ++ + PRGSG ++TR P+ + L + + K S +++++ + D + + EI
Sbjct: 361 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF-KDSSREFDLTKEEDLAALRHEIE 419
Query: 145 KAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKK 204
EG +S E I+L + + + L+DLPG+ D I ++ K
Sbjct: 420 LRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKA 479
Query: 205 YIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDK--GTEDKVVD 262
Y+Q I L + +VD + + ++DP G RTI +LTK DL +K + ++
Sbjct: 480 YMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQ 539
Query: 263 VVRNLVFHLKK-GYM-IVKCRGQQEIQDQLSLSEALQREKIFFENHPYFR-DLLEEGKAT 319
++ +F +K GY +V +G S+ + E+ FF+N + +L+ + T
Sbjct: 540 IIEGKLFPMKALGYFAVVTGKG----NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT 595
Query: 320 VPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPE-DENEKMFFLIDK 378
L+ ++ + +S+ + K T + E + + E D NE L +K
Sbjct: 596 TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNE----LFEK 651
Query: 379 V-NAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKIL-----SRK 432
N ++ +L Q EE ++ R H +IEN + + + +
Sbjct: 652 AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH----VIENIYLPAAQTMNSGTFNTT 707
Query: 433 IQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIK 490
+ Q+ ++LP +ET+ ++ + + EP + D ++ A + SIK
Sbjct: 708 VDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIK 765
>gi|224831251 optic atrophy 1 isoform 7 [Homo sapiens]
Length = 997
Score = 102 bits (253), Expect = 1e-21
Identities = 113/478 (23%), Positives = 210/478 (43%), Gaps = 29/478 (6%)
Query: 28 VAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVL 87
V QK+ + L + +D++ A QD LP + V+GDQS+GK+SVL
Sbjct: 284 VLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQD-HLPRVVVVGDQSAGKTSVL 342
Query: 88 EALSGVAL-PRGSG-IVTRCPLVLKLKKLVNEDKWRGKVSYQDYEI-EISDASEVEKEIN 144
E ++ + PRGSG ++TR P+ + L + + K S +++++ + D + + EI
Sbjct: 343 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF-KDSSREFDLTKEEDLAALRHEIE 401
Query: 145 KAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKK 204
EG +S E I+L + + + L+DLPG+ D I ++ K
Sbjct: 402 LRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKA 461
Query: 205 YIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDK--GTEDKVVD 262
Y+Q I L + +VD + + ++DP G RTI +LTK DL +K + ++
Sbjct: 462 YMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQ 521
Query: 263 VVRNLVFHLKK-GYM-IVKCRGQQEIQDQLSLSEALQREKIFFENHPYFR-DLLEEGKAT 319
++ +F +K GY +V +G S+ + E+ FF+N + +L+ + T
Sbjct: 522 IIEGKLFPMKALGYFAVVTGKG----NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT 577
Query: 320 VPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPE-DENEKMFFLIDK 378
L+ ++ + +S+ + K T + E + + E D NE L +K
Sbjct: 578 TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNE----LFEK 633
Query: 379 V-NAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKIL-----SRK 432
N ++ +L Q EE ++ R H +IEN + + + +
Sbjct: 634 AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH----VIENIYLPAAQTMNSGTFNTT 689
Query: 433 IQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIK 490
+ Q+ ++LP +ET+ ++ + + EP + D ++ A + SIK
Sbjct: 690 VDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIK 747
>gi|18860841 optic atrophy 1 isoform 6 [Homo sapiens]
Length = 979
Score = 102 bits (253), Expect = 1e-21
Identities = 113/478 (23%), Positives = 210/478 (43%), Gaps = 29/478 (6%)
Query: 28 VAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVL 87
V QK+ + L + +D++ A QD LP + V+GDQS+GK+SVL
Sbjct: 266 VLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQD-HLPRVVVVGDQSAGKTSVL 324
Query: 88 EALSGVAL-PRGSG-IVTRCPLVLKLKKLVNEDKWRGKVSYQDYEI-EISDASEVEKEIN 144
E ++ + PRGSG ++TR P+ + L + + K S +++++ + D + + EI
Sbjct: 325 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF-KDSSREFDLTKEEDLAALRHEIE 383
Query: 145 KAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKK 204
EG +S E I+L + + + L+DLPG+ D I ++ K
Sbjct: 384 LRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKA 443
Query: 205 YIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDK--GTEDKVVD 262
Y+Q I L + +VD + + ++DP G RTI +LTK DL +K + ++
Sbjct: 444 YMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQ 503
Query: 263 VVRNLVFHLKK-GYM-IVKCRGQQEIQDQLSLSEALQREKIFFENHPYFR-DLLEEGKAT 319
++ +F +K GY +V +G S+ + E+ FF+N + +L+ + T
Sbjct: 504 IIEGKLFPMKALGYFAVVTGKG----NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT 559
Query: 320 VPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPE-DENEKMFFLIDK 378
L+ ++ + +S+ + K T + E + + E D NE L +K
Sbjct: 560 TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNE----LFEK 615
Query: 379 V-NAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKIL-----SRK 432
N ++ +L Q EE ++ R H +IEN + + + +
Sbjct: 616 AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH----VIENIYLPAAQTMNSGTFNTT 671
Query: 433 IQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIK 490
+ Q+ ++LP +ET+ ++ + + EP + D ++ A + SIK
Sbjct: 672 VDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIK 729
>gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens]
Length = 978
Score = 102 bits (253), Expect = 1e-21
Identities = 113/478 (23%), Positives = 210/478 (43%), Gaps = 29/478 (6%)
Query: 28 VAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVL 87
V QK+ + L + +D++ A QD LP + V+GDQS+GK+SVL
Sbjct: 265 VLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQD-HLPRVVVVGDQSAGKTSVL 323
Query: 88 EALSGVAL-PRGSG-IVTRCPLVLKLKKLVNEDKWRGKVSYQDYEI-EISDASEVEKEIN 144
E ++ + PRGSG ++TR P+ + L + + K S +++++ + D + + EI
Sbjct: 324 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF-KDSSREFDLTKEEDLAALRHEIE 382
Query: 145 KAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKK 204
EG +S E I+L + + + L+DLPG+ D I ++ K
Sbjct: 383 LRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKA 442
Query: 205 YIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDK--GTEDKVVD 262
Y+Q I L + +VD + + ++DP G RTI +LTK DL +K + ++
Sbjct: 443 YMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQ 502
Query: 263 VVRNLVFHLKK-GYM-IVKCRGQQEIQDQLSLSEALQREKIFFENHPYFR-DLLEEGKAT 319
++ +F +K GY +V +G S+ + E+ FF+N + +L+ + T
Sbjct: 503 IIEGKLFPMKALGYFAVVTGKG----NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT 558
Query: 320 VPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPE-DENEKMFFLIDK 378
L+ ++ + +S+ + K T + E + + E D NE L +K
Sbjct: 559 TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNE----LFEK 614
Query: 379 V-NAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKIL-----SRK 432
N ++ +L Q EE ++ R H +IEN + + + +
Sbjct: 615 AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH----VIENIYLPAAQTMNSGTFNTT 670
Query: 433 IQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIK 490
+ Q+ ++LP +ET+ ++ + + EP + D ++ A + SIK
Sbjct: 671 VDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIK 728
>gi|18860835 optic atrophy 1 isoform 4 [Homo sapiens]
Length = 961
Score = 102 bits (253), Expect = 1e-21
Identities = 113/478 (23%), Positives = 210/478 (43%), Gaps = 29/478 (6%)
Query: 28 VAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVL 87
V QK+ + L + +D++ A QD LP + V+GDQS+GK+SVL
Sbjct: 248 VLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQD-HLPRVVVVGDQSAGKTSVL 306
Query: 88 EALSGVAL-PRGSG-IVTRCPLVLKLKKLVNEDKWRGKVSYQDYEI-EISDASEVEKEIN 144
E ++ + PRGSG ++TR P+ + L + + K S +++++ + D + + EI
Sbjct: 307 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF-KDSSREFDLTKEEDLAALRHEIE 365
Query: 145 KAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKK 204
EG +S E I+L + + + L+DLPG+ D I ++ K
Sbjct: 366 LRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKA 425
Query: 205 YIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDK--GTEDKVVD 262
Y+Q I L + +VD + + ++DP G RTI +LTK DL +K + ++
Sbjct: 426 YMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQ 485
Query: 263 VVRNLVFHLKK-GYM-IVKCRGQQEIQDQLSLSEALQREKIFFENHPYFR-DLLEEGKAT 319
++ +F +K GY +V +G S+ + E+ FF+N + +L+ + T
Sbjct: 486 IIEGKLFPMKALGYFAVVTGKG----NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT 541
Query: 320 VPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPE-DENEKMFFLIDK 378
L+ ++ + +S+ + K T + E + + E D NE L +K
Sbjct: 542 TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNE----LFEK 597
Query: 379 V-NAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKIL-----SRK 432
N ++ +L Q EE ++ R H +IEN + + + +
Sbjct: 598 AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH----VIENIYLPAAQTMNSGTFNTT 653
Query: 433 IQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIK 490
+ Q+ ++LP +ET+ ++ + + EP + D ++ A + SIK
Sbjct: 654 VDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIK 711
>gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens]
Length = 942
Score = 102 bits (253), Expect = 1e-21
Identities = 113/478 (23%), Positives = 210/478 (43%), Gaps = 29/478 (6%)
Query: 28 VAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVL 87
V QK+ + L + +D++ A QD LP + V+GDQS+GK+SVL
Sbjct: 229 VLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQD-HLPRVVVVGDQSAGKTSVL 287
Query: 88 EALSGVAL-PRGSG-IVTRCPLVLKLKKLVNEDKWRGKVSYQDYEI-EISDASEVEKEIN 144
E ++ + PRGSG ++TR P+ + L + + K S +++++ + D + + EI
Sbjct: 288 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF-KDSSREFDLTKEEDLAALRHEIE 346
Query: 145 KAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKK 204
EG +S E I+L + + + L+DLPG+ D I ++ K
Sbjct: 347 LRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKA 406
Query: 205 YIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDK--GTEDKVVD 262
Y+Q I L + +VD + + ++DP G RTI +LTK DL +K + ++
Sbjct: 407 YMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQ 466
Query: 263 VVRNLVFHLKK-GYM-IVKCRGQQEIQDQLSLSEALQREKIFFENHPYFR-DLLEEGKAT 319
++ +F +K GY +V +G S+ + E+ FF+N + +L+ + T
Sbjct: 467 IIEGKLFPMKALGYFAVVTGKG----NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT 522
Query: 320 VPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPE-DENEKMFFLIDK 378
L+ ++ + +S+ + K T + E + + E D NE L +K
Sbjct: 523 TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNE----LFEK 578
Query: 379 V-NAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKIL-----SRK 432
N ++ +L Q EE ++ R H +IEN + + + +
Sbjct: 579 AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH----VIENIYLPAAQTMNSGTFNTT 634
Query: 433 IQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIK 490
+ Q+ ++LP +ET+ ++ + + EP + D ++ A + SIK
Sbjct: 635 VDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIK 692
>gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens]
Length = 924
Score = 102 bits (253), Expect = 1e-21
Identities = 113/478 (23%), Positives = 210/478 (43%), Gaps = 29/478 (6%)
Query: 28 VAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVL 87
V QK+ + L + +D++ A QD LP + V+GDQS+GK+SVL
Sbjct: 211 VLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQD-HLPRVVVVGDQSAGKTSVL 269
Query: 88 EALSGVAL-PRGSG-IVTRCPLVLKLKKLVNEDKWRGKVSYQDYEI-EISDASEVEKEIN 144
E ++ + PRGSG ++TR P+ + L + + K S +++++ + D + + EI
Sbjct: 270 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF-KDSSREFDLTKEEDLAALRHEIE 328
Query: 145 KAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKK 204
EG +S E I+L + + + L+DLPG+ D I ++ K
Sbjct: 329 LRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKA 388
Query: 205 YIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDK--GTEDKVVD 262
Y+Q I L + +VD + + ++DP G RTI +LTK DL +K + ++
Sbjct: 389 YMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQ 448
Query: 263 VVRNLVFHLKK-GYM-IVKCRGQQEIQDQLSLSEALQREKIFFENHPYFR-DLLEEGKAT 319
++ +F +K GY +V +G S+ + E+ FF+N + +L+ + T
Sbjct: 449 IIEGKLFPMKALGYFAVVTGKG----NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT 504
Query: 320 VPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPE-DENEKMFFLIDK 378
L+ ++ + +S+ + K T + E + + E D NE L +K
Sbjct: 505 TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNE----LFEK 560
Query: 379 V-NAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKIL-----SRK 432
N ++ +L Q EE ++ R H +IEN + + + +
Sbjct: 561 AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH----VIENIYLPAAQTMNSGTFNTT 616
Query: 433 IQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIK 490
+ Q+ ++LP +ET+ ++ + + EP + D ++ A + SIK
Sbjct: 617 VDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIK 674
>gi|224831243 optic atrophy 1 isoform 1 [Homo sapiens]
Length = 960
Score = 102 bits (253), Expect = 1e-21
Identities = 113/478 (23%), Positives = 210/478 (43%), Gaps = 29/478 (6%)
Query: 28 VAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVL 87
V QK+ + L + +D++ A QD LP + V+GDQS+GK+SVL
Sbjct: 247 VLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQD-HLPRVVVVGDQSAGKTSVL 305
Query: 88 EALSGVAL-PRGSG-IVTRCPLVLKLKKLVNEDKWRGKVSYQDYEI-EISDASEVEKEIN 144
E ++ + PRGSG ++TR P+ + L + + K S +++++ + D + + EI
Sbjct: 306 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF-KDSSREFDLTKEEDLAALRHEIE 364
Query: 145 KAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKK 204
EG +S E I+L + + + L+DLPG+ D I ++ K
Sbjct: 365 LRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKA 424
Query: 205 YIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDK--GTEDKVVD 262
Y+Q I L + +VD + + ++DP G RTI +LTK DL +K + ++
Sbjct: 425 YMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQ 484
Query: 263 VVRNLVFHLKK-GYM-IVKCRGQQEIQDQLSLSEALQREKIFFENHPYFR-DLLEEGKAT 319
++ +F +K GY +V +G S+ + E+ FF+N + +L+ + T
Sbjct: 485 IIEGKLFPMKALGYFAVVTGKG----NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT 540
Query: 320 VPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPE-DENEKMFFLIDK 378
L+ ++ + +S+ + K T + E + + E D NE L +K
Sbjct: 541 TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNE----LFEK 596
Query: 379 V-NAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKIL-----SRK 432
N ++ +L Q EE ++ R H +IEN + + + +
Sbjct: 597 AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH----VIENIYLPAAQTMNSGTFNTT 652
Query: 433 IQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIK 490
+ Q+ ++LP +ET+ ++ + + EP + D ++ A + SIK
Sbjct: 653 VDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIK 710
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 44.3 bits (103), Expect = 4e-04
Identities = 94/421 (22%), Positives = 174/421 (41%), Gaps = 69/421 (16%)
Query: 283 QQEIQDQLSLSEALQREKIFFENHPYFRDLLEEG------KATVPCLAEKLTSELITHIC 336
QQ+IQ++ L Q+E + E P + LL+E K V C AEK+ +L
Sbjct: 1966 QQQIQEERELLSR-QKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQ---- 2020
Query: 337 KSLPLLENQIKETHQRITEELQKYGVDIP---------EDENEKMFFLIDKV-------- 379
K + LE ++E R E Q+ ++ E + EKM +D+
Sbjct: 2021 KQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHER 2080
Query: 380 NAFNQDITALMQGEETVGE----------EDIRLFTRLRHEFHKWSTIIENNFQEGHKIL 429
+ F Q+I L Q + V E +L L+ + K S ++ + Q I
Sbjct: 2081 DVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQ 2140
Query: 430 SR--KIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRL-AFTD 486
R +I+K E + R E V+ TF+ + ++ AV+ ++ V+L A D
Sbjct: 2141 ERNEEIEKLEFRVRELEQALLVSADTFQKVEDRK----HFGAVEAKPELSLEVQLQAERD 2196
Query: 487 VSIKNFEEFFNLHRTAKSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRGALQKVR 546
+ +E NL + ++E R E E + E++ +LH Q+E + R
Sbjct: 2197 AIDRKEKEITNL----EEQLEQFREELENKNEEVQQLHMQLE---------IQKKESTTR 2243
Query: 547 EKELEEEKKKKSWDFG----AFQSSSATDSSMEEI----FQHLMAYHQEASKRISSHIPL 598
+ELE+E K D A + S A + + + F ++ + +++ +
Sbjct: 2244 LQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTK 2303
Query: 599 IIQFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDTSDKRKFLKERLARLTQARRRLA 658
+ Q + T + +++ +L++D +T L SD ++ +E + +L + +L
Sbjct: 2304 LQQQLKITTDNKVIEEKN-ELIRDLETQIECL--MSDQECVKRNREEEIEQLNEVIEKLQ 2360
Query: 659 Q 659
Q
Sbjct: 2361 Q 2361
Score = 33.1 bits (74), Expect = 0.84
Identities = 67/309 (21%), Positives = 123/309 (39%), Gaps = 41/309 (13%)
Query: 192 ADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDL 251
A+IG K T + + +E SL +D+ E L++ Q+V+ + +T
Sbjct: 2364 ANIGQK--TSMNAHSLSEEADSL---KHQLDVVIAEKLALEQQVETANEE----MTFMKN 2414
Query: 252 VDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQE----------IQDQLSLSEALQREKI 301
V K T K+ + + L ++ + K + E +D+ L L + +
Sbjct: 2415 VLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL 2474
Query: 302 -FFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLE--NQIK---ETHQRITE 355
EN YF+ E GK ++ L +L T K L L + QIK E Q TE
Sbjct: 2475 KSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETE 2534
Query: 356 ELQKYGVDIPEDENEKM-FFLIDKVN-AFNQDITALMQGEETVGEEDIRLFTRLRHEFHK 413
LQK V++ + EK+ L+ ++ Q+ Q +T+ E R
Sbjct: 2535 MLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERT------NIQN 2588
Query: 414 WSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDML 473
+ + E+ L+ +I + E+Q V T + K+Q++ E+ ++
Sbjct: 2589 LNQLREDELGSDISALTLRISELESQ--------VVEMHTSLILEKEQVEIAEKNVLEKE 2640
Query: 474 HTVTDMVRL 482
+ ++ +L
Sbjct: 2641 KKLLELQKL 2649
Score = 32.3 bits (72), Expect = 1.4
Identities = 56/245 (22%), Positives = 91/245 (37%), Gaps = 36/245 (14%)
Query: 347 KETH-QRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVGEEDIRLFT 405
+E H QRI K + +++ + ++ +D T LM+ E E + L
Sbjct: 898 EELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQ 957
Query: 406 RLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVK--QQIK 463
RL + ++ S K +K + R REL +N+ E + Q+
Sbjct: 958 RLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVS 1017
Query: 464 ALEEPAVDMLHTVTD----MVRLAFTD---------VSIKNF--------EEFFNLHRTA 502
+L + V M + V +F + VS +N E+ H +
Sbjct: 1018 SLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPS 1077
Query: 503 KSKIEDIRAEQEREGEKLIR-----------LHFQMEQIVYCQDQVYRGALQKVREKELE 551
+K +RA Q E +KL + L QME C VY + +VRE +E
Sbjct: 1078 VTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVRE-YME 1136
Query: 552 EEKKK 556
EK K
Sbjct: 1137 NEKDK 1141
Score = 32.0 bits (71), Expect = 1.9
Identities = 14/56 (25%), Positives = 37/56 (66%), Gaps = 8/56 (14%)
Query: 503 KSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRGALQKVREKELEEEKKKKS 558
+SK+ED++ + E + +++ +L + +++ +G +Q+ +++ELE E+K++S
Sbjct: 3409 QSKVEDLQRQLEEKRQQVYKLDLEGQRL--------QGIMQEFQKQELEREEKRES 3456
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 43.9 bits (102), Expect = 5e-04
Identities = 75/373 (20%), Positives = 154/373 (41%), Gaps = 48/373 (12%)
Query: 284 QEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLE 343
Q+++++L + +R + +N R +LE+ K + + + L K+L L
Sbjct: 697 QKLREELESQQKAERASLEQKN----RQMLEQLKEEIEASEKSEQAALNAAKEKALQQLR 752
Query: 344 NQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQG--EETVGEEDI 401
Q++ + L+K + + ++ L + A ++++ + +Q +E +E+
Sbjct: 753 EQLEGERKEAVATLEK-------EHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEA 805
Query: 402 RL---FTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIV 458
+L ++ H H+ S + E +L K Q+ E ++ R ++
Sbjct: 806 QLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKA 865
Query: 459 KQQIKALE--EPAVDMLHTVTDMVRLAFTDVSIKNFEEFFNLHRTAKSKIEDIRAEQERE 516
++Q +A E + A + H ++ RL + E + + ++ED+R +
Sbjct: 866 REQYEAEERKQRAELLGHLTGELERLQRA-----HERELETVRQEQHKRLEDLRRRHREQ 920
Query: 517 GEKLIRLHFQMEQIVYCQDQVYRGALQKVREKELEEEKKK----------KSWDFGAFQS 566
KL L +E +D R AL +V+E+ EK++ KS +
Sbjct: 921 ERKLQDLELDLE--TRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKS------EE 972
Query: 567 SSATDSSMEEIFQ---HLMAYHQEASKRISS----HIPLIIQFFMLQTYGQQLQKAMLQL 619
++AT +EE + HL+ +Q+ + + + L Q +LQ QQLQK L
Sbjct: 973 ATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSL 1032
Query: 620 LQDKDTYSWLLKE 632
+ LL+E
Sbjct: 1033 EAEAQKKQHLLRE 1045
Score = 35.8 bits (81), Expect = 0.13
Identities = 21/76 (27%), Positives = 42/76 (55%), Gaps = 1/76 (1%)
Query: 497 NLHRTAKSKIEDIRAEQ-EREGEKLIRLHFQMEQIVYCQDQVYRGALQKVREKELEEEKK 555
+L + + K++ +R + + E E+++RLH Q EQ + + + A+++ + EEE +
Sbjct: 609 HLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQ 668
Query: 556 KKSWDFGAFQSSSATD 571
+ SW QSS+ D
Sbjct: 669 RLSWLRAQVQSSTQAD 684
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 42.0 bits (97), Expect = 0.002
Identities = 72/354 (20%), Positives = 141/354 (39%), Gaps = 46/354 (12%)
Query: 325 EKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQ 384
EK + + ++ K L + Q+++T + + E ++ + I E ENE + NQ
Sbjct: 517 EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ-IKILEQENEHL----------NQ 565
Query: 385 DITALMQGEETVGE---EDIRLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKF-ENQY 440
+++L Q + E +DI ++ HE K ++ + + + + ++++ + E
Sbjct: 566 TVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE 625
Query: 441 RGRELPGFVNYRTFET-----------IVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSI 489
R EL +++ E I ++I+ALE+ ++ + +L T S
Sbjct: 626 RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELER---ENRKLKKTLDSF 682
Query: 490 KNFEEFFNLHRTAKSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRGALQKVREKE 549
KN S++++ E R E L +M Q+ ++ KE
Sbjct: 683 KNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL-------------QLENKE 729
Query: 550 LEEEKKKKSWDFGAFQSSSATDSSMEEIFQHLMAYHQEASKRISSHIPLIIQFFM----L 605
LE EK++ ++S +E +Q L +Q K + + I Q L
Sbjct: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 606 QTYGQQLQKAMLQLLQDKDTYSWLLKERSDTSDKRKFLKERLARLTQARRRLAQ 659
+ Q LQK + +L L KE + L++ +L + +RL Q
Sbjct: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ 843
Score = 29.6 bits (65), Expect = 9.3
Identities = 107/546 (19%), Positives = 204/546 (37%), Gaps = 76/546 (13%)
Query: 109 LKLKKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISS 168
L+L K + R +VSYQ +IE + + NK + E + E TL+ +
Sbjct: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL 800
Query: 169 RDVP----DLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIA 224
++ L ++ + +Q +++ K+ Q+ E + +NV I
Sbjct: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860
Query: 225 TTE----ALSMAQEVDPEGDRTIGILTKP--DLVDKGTEDKVVDVVRNLVFHLKKGYMIV 278
E LS + E + L K +LV + T D ++ LV L++ +
Sbjct: 861 NLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID-----IKTLVT-LREDLVSE 914
Query: 279 KCRGQQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKS 338
K + QQ D L+ L++ + E LL + ++T + L S+L + + KS
Sbjct: 915 KLKTQQMNNDLEKLTHELEKIGLNKER------LLHDEQSTDDSRYKLLESKLESTLKKS 968
Query: 339 LPLLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVGE 398
L + E +I R+ EE Y + ++ + ++ AL Q ++ E
Sbjct: 969 LEIKEEKIAALEARL-EESTNYNQQLRQE-----------LKTVKKNYEALKQRQDE--E 1014
Query: 399 EDIRLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIV 458
++ + E +KW + +E K+ R I+ N + + +
Sbjct: 1015 RMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNN---------ATLQAEKQAL 1065
Query: 459 KQQIKALEEPAVDMLHTVTDMVRLAFTDVSIKNFEEFFNLHRTAKSKIEDIRAEQEREGE 518
K Q+K LE ++ + + R + +E +T +K++ + +
Sbjct: 1066 KTQLKQLETQNNNLQAQILALQRQTVS------LQEQNTTLQTQNAKLQVENSTLNSQST 1119
Query: 519 KLIRLHFQMEQIVYCQDQVYRGALQKVREKELEEEKKKKSWDFGAFQSSSATDSSMEEIF 578
L+ + Q+ + + +L+ E ++E + KS S D E+
Sbjct: 1120 SLMNQNAQL--------LIQQSSLENENESVIKEREDLKS-----LYDSLIKDHEKLELL 1166
Query: 579 QHLMAYHQEASKRISSHIPLIIQFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDTSD 638
A E+ IS H L L+ + L+ D Y+ LLK++ D
Sbjct: 1167 HERQASEYESL--ISKHGTLKSAHKNLEVEHRDLE----------DRYNQLLKQKGQLED 1214
Query: 639 KRKFLK 644
K LK
Sbjct: 1215 LEKMLK 1220
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 42.0 bits (97), Expect = 0.002
Identities = 72/354 (20%), Positives = 141/354 (39%), Gaps = 46/354 (12%)
Query: 325 EKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQ 384
EK + + ++ K L + Q+++T + + E ++ + I E ENE + NQ
Sbjct: 517 EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ-IKILEQENEHL----------NQ 565
Query: 385 DITALMQGEETVGE---EDIRLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKF-ENQY 440
+++L Q + E +DI ++ HE K ++ + + + + ++++ + E
Sbjct: 566 TVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE 625
Query: 441 RGRELPGFVNYRTFET-----------IVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSI 489
R EL +++ E I ++I+ALE+ ++ + +L T S
Sbjct: 626 RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELER---ENRKLKKTLDSF 682
Query: 490 KNFEEFFNLHRTAKSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRGALQKVREKE 549
KN S++++ E R E L +M Q+ ++ KE
Sbjct: 683 KNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL-------------QLENKE 729
Query: 550 LEEEKKKKSWDFGAFQSSSATDSSMEEIFQHLMAYHQEASKRISSHIPLIIQFFM----L 605
LE EK++ ++S +E +Q L +Q K + + I Q L
Sbjct: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 606 QTYGQQLQKAMLQLLQDKDTYSWLLKERSDTSDKRKFLKERLARLTQARRRLAQ 659
+ Q LQK + +L L KE + L++ +L + +RL Q
Sbjct: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ 843
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 41.6 bits (96), Expect = 0.002
Identities = 85/409 (20%), Positives = 173/409 (42%), Gaps = 53/409 (12%)
Query: 283 QQEIQDQLSLSEALQREKIFFENHPYFRDLLEEG------KATVPCLAEKLTSELITHIC 336
QQ+IQ++ L Q+E + E P + LL+E K V C AEK+ +L
Sbjct: 1966 QQQIQEERELLSR-QKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQ---- 2020
Query: 337 KSLPLLENQIKETHQRITEELQKYGVDIPE--DENEKMFFLIDKVNAFNQDITALMQGEE 394
K + LE ++E R E Q+ ++ + +N+ + ++K+ F + + E
Sbjct: 2021 KQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHER 2080
Query: 395 TVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKI---LSRKIQKFENQYRGRE-LPGFVN 450
V +++I+ + ++ I E+ +E ++ L K K +E L +
Sbjct: 2081 DVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQ 2140
Query: 451 YRTFETI-VKQQIKALEEP----------AVDMLHTVTDMVRL-AFTDVSIKNFEEFFNL 498
R E ++ +++ LE+ AV+ ++ V+L A D + +E NL
Sbjct: 2141 ERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNL 2200
Query: 499 HRTAKSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRGALQKVREKELEEEKKKKS 558
+ ++E R E E + E++ +LH Q+E + R +ELE+E K
Sbjct: 2201 ----EEQLEQFREELENKNEEVQQLHMQLE---------IQKKESTTRLQELEQENKLFK 2247
Query: 559 WDFG----AFQSSSATDSSMEEI----FQHLMAYHQEASKRISSHIPLIIQFFMLQTYGQ 610
D A + S A + + + F ++ + +++ + + Q + T +
Sbjct: 2248 DDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK 2307
Query: 611 QLQKAMLQLLQDKDTYSWLLKERSDTSDKRKFLKERLARLTQARRRLAQ 659
+++ +L++D +T L SD ++ +E + +L + +L Q
Sbjct: 2308 VIEEKN-ELIRDLETQIECL--MSDQECVKRNREEEIEQLNEVIEKLQQ 2353
Score = 33.1 bits (74), Expect = 0.84
Identities = 67/309 (21%), Positives = 123/309 (39%), Gaps = 41/309 (13%)
Query: 192 ADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDL 251
A+IG K T + + +E SL +D+ E L++ Q+V+ + +T
Sbjct: 2356 ANIGQK--TSMNAHSLSEEADSL---KHQLDVVIAEKLALEQQVETANEE----MTFMKN 2406
Query: 252 VDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQE----------IQDQLSLSEALQREKI 301
V K T K+ + + L ++ + K + E +D+ L L + +
Sbjct: 2407 VLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL 2466
Query: 302 -FFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLE--NQIK---ETHQRITE 355
EN YF+ E GK ++ L +L T K L L + QIK E Q TE
Sbjct: 2467 KSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETE 2526
Query: 356 ELQKYGVDIPEDENEKM-FFLIDKVN-AFNQDITALMQGEETVGEEDIRLFTRLRHEFHK 413
LQK V++ + EK+ L+ ++ Q+ Q +T+ E R
Sbjct: 2527 MLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERT------NIQN 2580
Query: 414 WSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDML 473
+ + E+ L+ +I + E+Q V T + K+Q++ E+ ++
Sbjct: 2581 LNQLREDELGSDISALTLRISELESQ--------VVEMHTSLILEKEQVEIAEKNVLEKE 2632
Query: 474 HTVTDMVRL 482
+ ++ +L
Sbjct: 2633 KKLLELQKL 2641
Score = 32.3 bits (72), Expect = 1.4
Identities = 56/245 (22%), Positives = 91/245 (37%), Gaps = 36/245 (14%)
Query: 347 KETH-QRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVGEEDIRLFT 405
+E H QRI K + +++ + ++ +D T LM+ E E + L
Sbjct: 898 EELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQ 957
Query: 406 RLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVK--QQIK 463
RL + ++ S K +K + R REL +N+ E + Q+
Sbjct: 958 RLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVS 1017
Query: 464 ALEEPAVDMLHTVTD----MVRLAFTD---------VSIKNF--------EEFFNLHRTA 502
+L + V M + V +F + VS +N E+ H +
Sbjct: 1018 SLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPS 1077
Query: 503 KSKIEDIRAEQEREGEKLIR-----------LHFQMEQIVYCQDQVYRGALQKVREKELE 551
+K +RA Q E +KL + L QME C VY + +VRE +E
Sbjct: 1078 VTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVRE-YME 1136
Query: 552 EEKKK 556
EK K
Sbjct: 1137 NEKDK 1141
Score = 32.0 bits (71), Expect = 1.9
Identities = 14/56 (25%), Positives = 37/56 (66%), Gaps = 8/56 (14%)
Query: 503 KSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRGALQKVREKELEEEKKKKS 558
+SK+ED++ + E + +++ +L + +++ +G +Q+ +++ELE E+K++S
Sbjct: 3401 QSKVEDLQRQLEEKRQQVYKLDLEGQRL--------QGIMQEFQKQELEREEKRES 3448
>gi|4826870 nucleobindin 2 [Homo sapiens]
Length = 420
Score = 38.5 bits (88), Expect = 0.020
Identities = 60/261 (22%), Positives = 103/261 (39%), Gaps = 56/261 (21%)
Query: 304 ENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVD 363
E Y + L EE + E++ + H + P ++Q+KE + EE G+D
Sbjct: 187 ERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKE----VWEETD--GLD 240
Query: 364 IPEDENEKMFFLIDKVNAFN----QDITALMQGE-----ETVGEEDIRLFT---RLRHEF 411
P D + K FF + VN+ Q++ AL E + EED + RLR
Sbjct: 241 -PNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMRE 299
Query: 412 HKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVD 471
H + + N ++ E + E F+ ++ET+ +QQ
Sbjct: 300 HVMNEVDTNK---------DRLVTLEEFLKATEKKEFLEPDSWETLDQQQF--------- 341
Query: 472 MLHTVTDMVRLAFTDVSIKNFEEFFNLHRTAKSKIEDIRAEQEREGEKLIRLHFQMEQIV 531
FT+ +K +E L K D E +++ E+L R H Q+E
Sbjct: 342 ------------FTEEELKEYENIIALQENELKKKAD---ELQKQKEELQRQHDQLE--- 383
Query: 532 YCQDQVYRGALQKVREKELEE 552
Q Y +Q++ +K+L++
Sbjct: 384 -AQKLEYHQVIQQMEQKKLQQ 403
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 36.2 bits (82), Expect = 0.099
Identities = 60/291 (20%), Positives = 112/291 (38%), Gaps = 79/291 (27%)
Query: 313 LEEGKATVPCLAEKLTSE----------LITHICKSLPLLENQIKETHQ----------R 352
+EE K+ C EK E + I K +L+ +K++ Q R
Sbjct: 705 IEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKER 764
Query: 353 ITEELQKYGVDIPEDENEKMFFLID-KVNAFNQDITALMQGEETVGEEDIRLFTRLRHEF 411
+ +E++ + + ++ N+++ + K AF D ++G E +++I
Sbjct: 765 MEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADN---LKGLEKQMKQEI---------- 811
Query: 412 HKWSTIIENNFQEGHKILSRKIQKFENQYRG-----RELPGFVN-YRTFETIVKQQIKAL 465
N E ++L ++ + QYRG REL + + F T+ K Q+K L
Sbjct: 812 --------NTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKEL 863
Query: 466 EEPAVDMLHTVTDMVRLAFTDVSIKNFEEFFNLHRTAKSKIEDIRAEQEREGEKLIRLHF 525
+E ++ KN E KI++++ E+E +L
Sbjct: 864 KE------------------EIEEKNRENL--------KKIQELQNEKETLATQLDLAET 897
Query: 526 QMEQIVYCQDQVYRGALQKVREKELEEEKKKKSWDFGAFQSSSATDSSMEE 576
+ E +Q+ RG L++ + +E KK S + T S +EE
Sbjct: 898 KAE-----SEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEE 943
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 36.2 bits (82), Expect = 0.099
Identities = 47/211 (22%), Positives = 89/211 (42%), Gaps = 26/211 (12%)
Query: 452 RTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIKNFEEFFNLHRTAKSKIEDIRA 511
R E + Q + LEE +M + D R V N E R+A K ++ R
Sbjct: 1732 RRLEARIAQLEEELEEEQSNM-ELLNDRFRKTTLQVDTLNAE--LAAERSAAQKSDNARQ 1788
Query: 512 EQEREGEKLIRLHFQMEQIVYCQDQVYRGALQKV---REKELEEEKKKKSWDFGAFQSSS 568
+ ER+ ++L ++E V + + AL+ E++LE+E K+++ A +
Sbjct: 1789 QLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERA---AANKLVR 1845
Query: 569 ATDSSMEEIFQHLMAYHQEASKRISSHIPLIIQFFMLQTYGQQLQKAMLQLLQDKDTYSW 628
T+ ++EIF + + A + Y +Q++KA ++ Q K
Sbjct: 1846 RTEKKLKEIFMQVEDERRHADQ-----------------YKEQMEKANARMKQLKRQLEE 1888
Query: 629 LLKERSDTSDKRKFLKERLARLTQARRRLAQ 659
+E + + R+ L+ L T+A L++
Sbjct: 1889 AEEEATRANASRRKLQRELDDATEANEGLSR 1919
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,891,528
Number of Sequences: 37866
Number of extensions: 998678
Number of successful extensions: 4157
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 108
Number of HSP's that attempted gapping in prelim test: 3977
Number of HSP's gapped (non-prelim): 268
length of query: 662
length of database: 18,247,518
effective HSP length: 109
effective length of query: 553
effective length of database: 14,120,124
effective search space: 7808428572
effective search space used: 7808428572
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.