Search of human proteins with 22129776

Search of human proteins with 22129776

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22129776 HtrA serine peptidase 3 [Homo sapiens]
         (453 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22129776 HtrA serine peptidase 3 [Homo sapiens]                    908   0.0  
gi|4506141 HtrA serine peptidase 1 precursor [Homo sapiens]           511   e-145
gi|24308541 HtrA serine peptidase 4 precursor [Homo sapiens]          425   e-119
gi|7019477 HtrA serine peptidase 2 isoform 1 preproprotein [Homo...   341   7e-94
gi|21614538 HtrA serine peptidase 2 isoform 2 [Homo sapiens]          114   2e-25
gi|4504619 insulin-like growth factor binding protein 7 [Homo sa...    84   3e-16
gi|19923632 Kazal-type serine peptidase inhibitor domain 1 precu...    73   5e-13
gi|56090548 insulin-like growth factor binding protein-like 1 [H...    73   5e-13
gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens]                55   1e-07
gi|5901946 endothelial cell-specific molecule 1 isoform a precur...    50   4e-06
gi|208022668 endothelial cell-specific molecule 1 isoform b prec...    50   4e-06
gi|62243068 insulin-like growth factor binding protein 3 isoform...    49   9e-06
gi|62243248 insulin-like growth factor binding protein 3 isoform...    49   9e-06
gi|31542331 cysteine-rich, angiogenic inducer, 61 [Homo sapiens]       47   3e-05
gi|4507923 WNT1 inducible signaling pathway protein 2 precursor ...    46   8e-05
gi|4505423 nephroblastoma overexpressed precursor [Homo sapiens]       45   1e-04
gi|54873613 agrin [Homo sapiens]                                       43   5e-04
gi|4503123 connective tissue growth factor [Homo sapiens]              42   9e-04
gi|21630285 PDZ domain containing 3 [Homo sapiens]                     40   0.004
gi|55925576 insulin-like growth factor binding protein 2, 36kDa ...    39   0.007
gi|38202241 WNT1 inducible signaling pathway protein 3 isoform 3...    39   0.007
gi|4507925 WNT1 inducible signaling pathway protein 3 isoform 1 ...    39   0.007
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof...    39   0.010
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo...    39   0.010
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]           38   0.022
gi|10834982 insulin-like growth factor binding protein 5 [Homo s...    38   0.022
gi|239752912 PREDICTED: hypothetical protein [Homo sapiens]            37   0.028
gi|30387650 late cornified envelope 1E [Homo sapiens]                  37   0.028
gi|30387652 late cornified envelope 1C [Homo sapiens]                  37   0.028
gi|62243290 insulin-like growth factor binding protein 4 precurs...    37   0.037

>gi|22129776 HtrA serine peptidase 3 [Homo sapiens]
          Length = 453

 Score =  908 bits (2347), Expect = 0.0
 Identities = 453/453 (100%), Positives = 453/453 (100%)

Query: 1   MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGE 60
           MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGE
Sbjct: 1   MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGE 60

Query: 61  PCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQ 120
           PCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQ
Sbjct: 61  PCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQ 120

Query: 121 LQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIM 180
           LQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIM
Sbjct: 121 LQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIM 180

Query: 181 SEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLP 240
           SEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLP
Sbjct: 181 SEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLP 240

Query: 241 VLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAII 300
           VLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAII
Sbjct: 241 VLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAII 300

Query: 301 NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIR 360
           NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIR
Sbjct: 301 NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIR 360

Query: 361 MRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSS 420
           MRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSS
Sbjct: 361 MRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSS 420

Query: 421 ELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM 453
           ELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM
Sbjct: 421 ELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM 453


>gi|4506141 HtrA serine peptidase 1 precursor [Homo sapiens]
          Length = 480

 Score =  511 bits (1315), Expect = e-145
 Identities = 270/472 (57%), Positives = 343/472 (72%), Gaps = 32/472 (6%)

Query: 6   LLLAALAALALARE----PPAAPCPARCDVSRCPSP--RCPGGYVPDLCNCCLVCAASEG 59
           LLLAA A+  L+R     P AA CP RC+ +RCP     C GG   D C CC VC A EG
Sbjct: 14  LLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEG 73

Query: 60  EPCGGPLDSPCGESLECV----------------RGLCRCRWSHAVCGTDGHTYANVCAL 103
             CG   + PCGE L+CV                 GLC C  S  VCG+D +TYAN+C L
Sbjct: 74  AACGLQ-EGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQL 132

Query: 104 QAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRH 163
           +AASRR+ +L   PV  LQ+GAC  G    +S R+K+NFIADVVEKIAPAVVHIELF + 
Sbjct: 133 RAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKL 192

Query: 164 PLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDID 223
           P   R VP++SGSGFI+SE GLI+TNAHVV++      + ++KV+L+NG +YEA IKD+D
Sbjct: 193 PFSKREVPVASGSGFIVSEDGLIVTNAHVVTN------KHRVKVELKNGATYEAKIKDVD 246

Query: 224 KKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRE 283
           +K+DIA IKI  + KLPVLLLG S++LRPGEFVVAIGSPF+LQNTVTTGIVST QR G+E
Sbjct: 247 EKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKE 306

Query: 284 LGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTE 343
           LGLR+SDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSD+I +FLTE
Sbjct: 307 LGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTE 366

Query: 344 FQDKQIKD---WKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRG 400
             D+Q K     KK++IGIRM ++T S   ELK  + DFP+V SG Y+ EV P++P++ G
Sbjct: 367 SHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAG 426

Query: 401 GIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVV 452
           G+++ D+I+ +NG+ +V ++++ + +  ES L + VRRGN+D++ ++ PE +
Sbjct: 427 GLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEI 478


>gi|24308541 HtrA serine peptidase 4 precursor [Homo sapiens]
          Length = 476

 Score =  425 bits (1092), Expect = e-119
 Identities = 227/443 (51%), Positives = 304/443 (68%), Gaps = 22/443 (4%)

Query: 25  CPARCDVSRCPS-PRCPGGYVP--DLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGL- 80
           CPA C  +RCP+ P C  G  P  DLC CC VC A+E E CGG    PC   L+C++ L 
Sbjct: 40  CPAVCQPTRCPALPTCALGTTPVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLR 99

Query: 81  ------CRC-RWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGAC-PLGLHQ 132
                 C C     AVCG+D  TY ++CAL+A +R A +L   P   +Q G C   G   
Sbjct: 100 PGFPSTCGCPTLGGAVCGSDRRTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRS 159

Query: 133 LSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHV 192
               R  +NFIA VVEK+AP+VVH++L+ R     R VP+ SGSGFI+SE GLIITNAHV
Sbjct: 160 AGPLRRNYNFIAAVVEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHV 219

Query: 193 VSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRP 252
           V +      +Q ++V LQNG  YEA +KDID K D+A IKI    +LPVL+LG S+DLR 
Sbjct: 220 VRN------QQWIEVVLQNGARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRA 273

Query: 253 GEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNL 312
           GEFVVA+GSPF+LQNT T GIVST QR G+ELG++DSDMDY+Q DA INYGNSGGPLVNL
Sbjct: 274 GEFVVALGSPFSLQNTATAGIVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNL 333

Query: 313 DGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKD---WKKRFIGIRMRTITPSLV 369
           DG+VIG+N+L+VT GISFAIPSDR+ +FL E+ + Q+K      K+++G++M ++T  L 
Sbjct: 334 DGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAFSNKKYLGLQMLSLTVPLS 393

Query: 370 DELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTE 429
           +ELK   PDFP+VSSG+YV +V   + +Q  G++D D+IV +NG+P+  ++++ +A+ ++
Sbjct: 394 EELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSD 453

Query: 430 SPLLLEVRRGNDDLLFSIAPEVV 452
           S L + V RG D+LL ++ PE +
Sbjct: 454 S-LSMAVLRGKDNLLLTVIPETI 475


>gi|7019477 HtrA serine peptidase 2 isoform 1 preproprotein [Homo
           sapiens]
          Length = 458

 Score =  341 bits (875), Expect = 7e-94
 Identities = 169/322 (52%), Positives = 241/322 (74%), Gaps = 10/322 (3%)

Query: 134 SSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVV 193
           +SPR ++NFIADVVEK APAVV+IE+  RHP  GR VP+S+GSGF+++  GLI+TNAHVV
Sbjct: 141 ASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVV 200

Query: 194 SSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPG 253
           +       R++++V+L +GD+YEA +  +D  +DIAT++I  K+ LP L LG SAD+R G
Sbjct: 201 AD------RRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQG 254

Query: 254 EFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLD 313
           EFVVA+GSPFALQNT+T+GIVS+AQR  R+LGL  ++++YIQTDA I++GNSGGPLVNLD
Sbjct: 255 EFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLD 314

Query: 314 GEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQ----IKDWKKRFIGIRMRTITPSLV 369
           GEVIG+NT+KVTAGISFAIPSDR+  FL   + K     I   ++R+IG+ M T++PS++
Sbjct: 315 GEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSIL 374

Query: 370 DELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTE 429
            EL+   P FP+V  G+ + +V   SP+ R G++ GD+I+ +  + + ++ ++ EAV T+
Sbjct: 375 AELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQ 434

Query: 430 SPLLLEVRRGNDDLLFSIAPEV 451
           S L +++RRG + L   + PEV
Sbjct: 435 SQLAVQIRRGRETLTLYVTPEV 456


>gi|21614538 HtrA serine peptidase 2 isoform 2 [Homo sapiens]
          Length = 361

 Score =  114 bits (284), Expect = 2e-25
 Identities = 55/103 (53%), Positives = 79/103 (76%), Gaps = 6/103 (5%)

Query: 134 SSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVV 193
           +SPR ++NFIADVVEK APAVV+IE+  RHP  GR VP+S+GSGF+++  GLI+TNAHVV
Sbjct: 141 ASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVV 200

Query: 194 SSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPK 236
           +       R++++V+L +GD+YEA +  +D  +DIAT++I  K
Sbjct: 201 AD------RRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTK 237



 Score =  107 bits (268), Expect = 2e-23
 Identities = 60/154 (38%), Positives = 88/154 (57%), Gaps = 36/154 (23%)

Query: 302 YGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQ----IKDWKKRFI 357
           +GNSGGPLVNLDGEVIG+NT+KVTAGISFAIPSDR+  FL   + K     I   ++R+I
Sbjct: 238 FGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYI 297

Query: 358 GIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLV 417
           G+ M T++P                                R G++ GD+I+ +  + + 
Sbjct: 298 GVMMLTLSP--------------------------------RAGLRPGDVILAIGEQMVQ 325

Query: 418 DSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEV 451
           ++ ++ EAV T+S L +++RRG + L   + PEV
Sbjct: 326 NAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEV 359


>gi|4504619 insulin-like growth factor binding protein 7 [Homo
           sapiens]
          Length = 282

 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 57/167 (34%), Positives = 74/167 (44%), Gaps = 31/167 (18%)

Query: 4   RALLLAALAALAL-------AREPPAAPC-PARCDVSRCPSPRCPGGYVPDLCNCCLVCA 55
           RALLL A   L L       +      PC PA C     P   C  G   D C CC +CA
Sbjct: 7   RALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPP--LPPLGCLLGETRDACGCCPMCA 64

Query: 56  ASEGEPCGGPLDSP--CGESLECVR-------------------GLCRCRWSHAVCGTDG 94
             EGEPCGG       C   +ECV+                   G+C C+  + VCG+DG
Sbjct: 65  RGEGEPCGGGGAGRGYCAPGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDG 124

Query: 95  HTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFN 141
            TY + C L+AAS+RA       + Q+ KG C  G   ++ P+  +N
Sbjct: 125 TTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWN 171


>gi|19923632 Kazal-type serine peptidase inhibitor domain 1
           precursor [Homo sapiens]
          Length = 304

 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 59/179 (32%), Positives = 70/179 (39%), Gaps = 43/179 (24%)

Query: 3   ARALLLAALAALALAREPP---AAPCP-------------------ARCDVSRCPSPR-C 39
           A AL L  L  L +   PP   A P P                   A C    C +PR C
Sbjct: 8   AAALALPVLLLLLVVLTPPPTGARPSPGPDYLRRGWMRLLAEGEGCAPCRPEECAAPRGC 67

Query: 40  PGGYVPDLCNCCLVCAASEGEPC----GGPLDSPCGESLEC--------VRG-----LCR 82
             G V D C CC  CA  EG+ C           CGE LEC         RG     LC 
Sbjct: 68  LAGRVRDACGCCWECANLEGQLCDLDPSAHFYGHCGEQLECRLDTGGDLSRGEVPEPLCA 127

Query: 83  CRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFN 141
           CR    +CG+DGHTY+ +C LQ A+R     + T       G C  G   +S P   +N
Sbjct: 128 CRSQSPLCGSDGHTYSQICRLQEAARARPDANLTVA---HPGPCESGPQIVSHPYDTWN 183


>gi|56090548 insulin-like growth factor binding protein-like 1 [Homo
           sapiens]
          Length = 278

 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 51/166 (30%), Positives = 65/166 (39%), Gaps = 25/166 (15%)

Query: 1   MQARALLLAALAALALAREPPAAPCPARCDVSR------------CPSPR---CPGGYVP 45
           M   +LLL  L  L L   PP +P     DV              CP+P     PG    
Sbjct: 1   MPRLSLLLPLLLLLLLPLLPPLSPSLGIRDVGGRRPKCGPCRPEGCPAPAPCPAPGISAL 60

Query: 46  DLCNCCLVCAASEGEPCGGPLDSPCGESLECVR----------GLCRCRWSHAVCGTDGH 95
           D C CC  C  +EG  CGG     CG  L C            GLC C     VCG+DG 
Sbjct: 61  DECGCCARCLGAEGASCGGRAGGRCGPGLVCASQAAGAAPEGTGLCVCAQRGTVCGSDGR 120

Query: 96  TYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFN 141
           +Y +VCAL+  +R   +     + + + G C      +  PR   N
Sbjct: 121 SYPSVCALRLRARHTPRAHPGHLHKARDGPCEFAPVVVVPPRSVHN 166


>gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens]
          Length = 1036

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 28/67 (41%), Positives = 32/67 (47%), Gaps = 3/67 (4%)

Query: 14 LALAREPPAAPCPARCDVSRCPSPR-CPGGYVPDLCNCCLVCAASEGEPCGGP--LDSPC 70
          L LAR    A     CD S+C  PR CPG  V  +C CC  CA+   E CGG   +   C
Sbjct: 25 LLLARSGTRALVCLPCDESKCEEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFGIYGTC 84

Query: 71 GESLECV 77
             L CV
Sbjct: 85 DRGLRCV 91


>gi|5901946 endothelial cell-specific molecule 1 isoform a
          precursor [Homo sapiens]
          Length = 184

 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 27/60 (45%), Positives = 28/60 (46%), Gaps = 6/60 (10%)

Query: 22 AAPCPARCDVSRCPS-PRCPGGYVPDLCNCCLVCAASEGEPC----GGPLDSPCGESLEC 76
          A  CP  CD S C S PRC    + D C CC VCAA  GE C     G     CG  L C
Sbjct: 25 AVDCPQHCDSSECKSSPRCKRTVLDD-CGCCRVCAAGRGETCYRTVSGMDGMKCGPGLRC 83


>gi|208022668 endothelial cell-specific molecule 1 isoform b
          precursor [Homo sapiens]
          Length = 134

 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 27/60 (45%), Positives = 28/60 (46%), Gaps = 6/60 (10%)

Query: 22 AAPCPARCDVSRCPS-PRCPGGYVPDLCNCCLVCAASEGEPC----GGPLDSPCGESLEC 76
          A  CP  CD S C S PRC    + D C CC VCAA  GE C     G     CG  L C
Sbjct: 25 AVDCPQHCDSSECKSSPRCKRTVLDD-CGCCRVCAAGRGETCYRTVSGMDGMKCGPGLRC 83


>gi|62243068 insulin-like growth factor binding protein 3 isoform
          b precursor [Homo sapiens]
          Length = 291

 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 33/88 (37%), Positives = 35/88 (39%), Gaps = 18/88 (20%)

Query: 6  LLLAALAALALAREPPAA----------------PCPARCDVSRCPSPRCPGGYVPDL-C 48
          L  AAL  L L R PP A                PC AR      P P      V +  C
Sbjct: 8  LWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGC 67

Query: 49 NCCLVCAASEGEPCGGPLDSPCGESLEC 76
           CCL CA SEG+PC G     CG  L C
Sbjct: 68 GCCLTCALSEGQPC-GIYTERCGSGLRC 94


>gi|62243248 insulin-like growth factor binding protein 3 isoform
          a precursor [Homo sapiens]
          Length = 297

 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 33/88 (37%), Positives = 35/88 (39%), Gaps = 18/88 (20%)

Query: 6  LLLAALAALALAREPPAA----------------PCPARCDVSRCPSPRCPGGYVPDL-C 48
          L  AAL  L L R PP A                PC AR      P P      V +  C
Sbjct: 8  LWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGC 67

Query: 49 NCCLVCAASEGEPCGGPLDSPCGESLEC 76
           CCL CA SEG+PC G     CG  L C
Sbjct: 68 GCCLTCALSEGQPC-GIYTERCGSGLRC 94


>gi|31542331 cysteine-rich, angiogenic inducer, 61 [Homo sapiens]
          Length = 381

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 38/111 (34%), Positives = 48/111 (43%), Gaps = 21/111 (18%)

Query: 3   ARALLLAA----LAALALAREPPAAPCPARCDVSRCPSPRC-PG-GYVPDLCNCCLVCA- 55
           ARAL L      L  LAL+  P A  CP         +P+C PG G V D C CC VCA 
Sbjct: 6   ARALALVVTLLHLTRLALSTCPAACHCPLE-------APKCAPGVGLVRDGCGCCKVCAK 58

Query: 56  -----ASEGEPCGGPLDSPC--GESLECVRGLCRCRWSHAVCGTDGHTYAN 99
                 S+ +PC       C  G S   ++G+CR +     C  +   Y N
Sbjct: 59  QLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQN 109


>gi|4507923 WNT1 inducible signaling pathway protein 2 precursor
           [Homo sapiens]
          Length = 250

 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 33/100 (33%), Positives = 38/100 (38%), Gaps = 11/100 (11%)

Query: 8   LAALAALALAREPPAAPCPARCDVSRCPSPRCPGGY--VPDLCNCCLVCAASEGEPCGGP 65
           L A + L L  +     CP  C     P PRCP G   V D C CC VCA   GEPC   
Sbjct: 9   LLAFSLLCLLSKVRTQLCPTPCTCP-WPPPRCPLGVPLVLDGCGCCRVCARRLGEPCDQL 67

Query: 66  LDSPCGESLECVRG--------LCRCRWSHAVCGTDGHTY 97
                 + L C  G        LC      + C  +G  Y
Sbjct: 68  HVCDASQGLVCQPGAGPGGRGALCLLAEDDSSCEVNGRLY 107


>gi|4505423 nephroblastoma overexpressed precursor [Homo sapiens]
          Length = 357

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 29/77 (37%), Positives = 36/77 (46%), Gaps = 7/77 (9%)

Query: 1  MQARALLLAALAALALAREPPAAPCPARCDVSRCPS--PRCPGGY--VPDLCNCCLVCAA 56
          ++ + L L  L    L +      CP +C   RCP+  P C  G   V D C+CCLVCA 
Sbjct: 11 LRKQCLCLTFLLLHLLGQVAATQRCPPQCP-GRCPATPPTCAPGVRAVLDGCSCCLVCAR 69

Query: 57 SEGEPCGGPLDSPCGES 73
            GE C      PC ES
Sbjct: 70 QRGESCSDL--EPCDES 84


>gi|54873613 agrin [Homo sapiens]
          Length = 2045

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 36/117 (30%), Positives = 45/117 (38%), Gaps = 22/117 (18%)

Query: 25  CPARCDVSRCPSPRCPGGYVPDLC----NCCL------VCAASEGEPCGGPLDSPCGESL 74
           CP+ C     P     G   P  C    + C       V +A   E CG   D+ C    
Sbjct: 555 CPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCG---DAVCAFGA 611

Query: 75  ECVRGLCRC-RWSHA----VCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGAC 126
            C  G C C R  H     VCG+DG TY + C L    R A  L  T + + + G C
Sbjct: 612 VCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACEL----REAACLQQTQIEEARAGPC 664



 Score = 36.2 bits (82), Expect = 0.063
 Identities = 22/58 (37%), Positives = 31/58 (53%), Gaps = 3/58 (5%)

Query: 73  SLECVRGLCRCRWSHA--VCGTDGHTYANVCALQA-ASRRALQLSGTPVRQLQKGACP 127
           S  CV  +  C  ++A  VCG+DG TY N C L+  A R+ LQ+S   +   Q+   P
Sbjct: 918 SAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAP 975



 Score = 33.5 bits (75), Expect = 0.41
 Identities = 29/92 (31%), Positives = 36/92 (39%), Gaps = 12/92 (13%)

Query: 35  PSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDG 94
           P P  P    PD C   L      G  C    + P   S  C +  C    +  VCG+D 
Sbjct: 163 PVPPTP----PDACRGML---CGFGAVCEPNAEGPGRASCVCKKSPCPSVVA-PVCGSDA 214

Query: 95  HTYANVCALQAASRRALQLSGTPVRQLQKGAC 126
            TY+N C LQ    RA       +R L +G C
Sbjct: 215 STYSNECELQ----RAQCSQQRRIRLLSRGPC 242



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 30/112 (26%), Positives = 45/112 (40%), Gaps = 22/112 (19%)

Query: 15  ALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESL 74
           A  R+  A P   +    + PSP C G      C     CA   G+            + 
Sbjct: 445 AECRQQRAIPSKHQGPCDQAPSP-CLGVQ----CAFGATCAVKNGQA-----------AC 488

Query: 75  ECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGAC 126
           EC++  C   +   VCG+DG TY + C L+A +       G  ++  +KG C
Sbjct: 489 ECLQA-CSSLYD-PVCGSDGVTYGSACELEATACTL----GREIQVARKGPC 534



 Score = 30.4 bits (67), Expect = 3.4
 Identities = 38/147 (25%), Positives = 51/147 (34%), Gaps = 54/147 (36%)

Query: 27  ARCDVSRCPSPRC----PG----------GYVPDLCNCCLVCAASEGEPCGGPLD----- 67
           A C   +C  PRC    PG          G   +L     +      E   GP +     
Sbjct: 611 AVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECG 670

Query: 68  ---SPCGESLECVRGLCRCR---WSH-------------------AVCGTDGHTYANVCA 102
              S  GE  +C + LCR R   W                      VCG+DG TY+  C 
Sbjct: 671 SGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECE 730

Query: 103 LQAA---SRRALQLSGTPVRQLQKGAC 126
           L+ A   S+R L ++        +GAC
Sbjct: 731 LKKARCESQRGLYVAA-------QGAC 750


>gi|4503123 connective tissue growth factor [Homo sapiens]
          Length = 349

 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 24/58 (41%), Positives = 27/58 (46%), Gaps = 3/58 (5%)

Query: 8  LAALAALALAREPPAAP-CPARCDVSRCPSPRCPGGY--VPDLCNCCLVCAASEGEPC 62
          +A +  LAL   P     C   C     P+PRCP G   V D C CC VCA   GE C
Sbjct: 11 VAFVVLLALCSRPAVGQNCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVCAKQLGELC 68


>gi|21630285 PDZ domain containing 3 [Homo sapiens]
          Length = 491

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 22/60 (36%), Positives = 36/60 (60%), Gaps = 5/60 (8%)

Query: 382 VSSG--IYVQEVAPNSPSQRGGIQDGDIIVKVNGRPL---VDSSELQEAVLTESPLLLEV 436
           V+SG  +++ +V P   + R G+Q GD+I++VNG P+    D   LQ+    E PL L++
Sbjct: 405 VASGPRLFISQVTPGGSAARAGLQVGDVILEVNGYPVGGQNDLERLQQLPEAEPPLCLKL 464


>gi|55925576 insulin-like growth factor binding protein 2, 36kDa
           [Homo sapiens]
          Length = 328

 Score = 39.3 bits (90), Expect = 0.007
 Identities = 24/63 (38%), Positives = 26/63 (41%), Gaps = 1/63 (1%)

Query: 14  LALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGES 73
           LA    PP AP  A   V+      C        C CC VCA  EGE C G     CG+ 
Sbjct: 53  LAACGPPPVAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEAC-GVYTPRCGQG 111

Query: 74  LEC 76
           L C
Sbjct: 112 LRC 114


>gi|38202241 WNT1 inducible signaling pathway protein 3 isoform 3
           [Homo sapiens]
          Length = 372

 Score = 39.3 bits (90), Expect = 0.007
 Identities = 23/62 (37%), Positives = 28/62 (45%), Gaps = 4/62 (6%)

Query: 33  RCPS--PRCPGGY--VPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHA 88
           +CP   PRCP G   V D C CC +CA   GE C         + L C   + R R+   
Sbjct: 71  KCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYETG 130

Query: 89  VC 90
           VC
Sbjct: 131 VC 132


>gi|4507925 WNT1 inducible signaling pathway protein 3 isoform 1
           [Homo sapiens]
          Length = 354

 Score = 39.3 bits (90), Expect = 0.007
 Identities = 23/62 (37%), Positives = 28/62 (45%), Gaps = 4/62 (6%)

Query: 33  RCPS--PRCPGGY--VPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHA 88
           +CP   PRCP G   V D C CC +CA   GE C         + L C   + R R+   
Sbjct: 53  KCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYETG 112

Query: 89  VC 90
           VC
Sbjct: 113 VC 114


>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform
           2 [Homo sapiens]
          Length = 1562

 Score = 38.9 bits (89), Expect = 0.010
 Identities = 17/45 (37%), Positives = 28/45 (62%)

Query: 386 IYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTES 430
           + VQ V P   + + G+++GD I+KVNG  + +SS L+   L +S
Sbjct: 67  VLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKS 111


>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform
           1 [Homo sapiens]
          Length = 1522

 Score = 38.9 bits (89), Expect = 0.010
 Identities = 17/45 (37%), Positives = 28/45 (62%)

Query: 386 IYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTES 430
           + VQ V P   + + G+++GD I+KVNG  + +SS L+   L +S
Sbjct: 67  VLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKS 111


>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
          Length = 1397

 Score = 37.7 bits (86), Expect = 0.022
 Identities = 20/65 (30%), Positives = 35/65 (53%), Gaps = 8/65 (12%)

Query: 386 IYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLF 445
           I+V+ V  + P+ R G++ GD +VKVNG  ++          T S ++  ++  +D L  
Sbjct: 4   IFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGK--------TYSQVIALIQNSDDTLEL 55

Query: 446 SIAPE 450
           SI P+
Sbjct: 56  SIMPK 60


>gi|10834982 insulin-like growth factor binding protein 5 [Homo
          sapiens]
          Length = 272

 Score = 37.7 bits (86), Expect = 0.022
 Identities = 27/80 (33%), Positives = 37/80 (46%), Gaps = 5/80 (6%)

Query: 1  MQARALLLAALA--ALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDL-CNCCLVCAAS 57
          + A  LLLAA A  A +L       PC  +  +S CP        V +  C CC+ CA +
Sbjct: 4  LTAVLLLLAAYAGPAQSLGSFVHCEPCDEKA-LSMCPPSPLGCELVKEPGCGCCMTCALA 62

Query: 58 EGEPCGGPLDSPCGESLECV 77
          EG+ C G     C + L C+
Sbjct: 63 EGQSC-GVYTERCAQGLRCL 81


>gi|239752912 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 118

 Score = 37.4 bits (85), Expect = 0.028
 Identities = 22/69 (31%), Positives = 27/69 (39%), Gaps = 3/69 (4%)

Query: 21 PAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLE--CVR 78
          P   C  +C   +CP+P+CP    P        C+ S G  CG      CG S    C  
Sbjct: 12 PPPKCTPKCP-PKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGSCGSSSGGCCSS 70

Query: 79 GLCRCRWSH 87
          G   C  SH
Sbjct: 71 GGGGCCLSH 79


>gi|30387650 late cornified envelope 1E [Homo sapiens]
          Length = 118

 Score = 37.4 bits (85), Expect = 0.028
 Identities = 22/69 (31%), Positives = 27/69 (39%), Gaps = 3/69 (4%)

Query: 21 PAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLE--CVR 78
          P   C  +C   +CP+P+CP    P        C+ S G  CG      CG S    C  
Sbjct: 12 PPPKCTPKCP-PKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGSCGSSSGGCCSS 70

Query: 79 GLCRCRWSH 87
          G   C  SH
Sbjct: 71 GGGGCCLSH 79


>gi|30387652 late cornified envelope 1C [Homo sapiens]
          Length = 118

 Score = 37.4 bits (85), Expect = 0.028
 Identities = 22/69 (31%), Positives = 27/69 (39%), Gaps = 3/69 (4%)

Query: 21 PAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLE--CVR 78
          P   C  +C   +CP+P+CP    P        C+ S G  CG      CG S    C  
Sbjct: 12 PPPKCTPKCP-PKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGSCGSSSGGCCSS 70

Query: 79 GLCRCRWSH 87
          G   C  SH
Sbjct: 71 GGGGCCLSH 79


>gi|62243290 insulin-like growth factor binding protein 4
          precursor [Homo sapiens]
          Length = 258

 Score = 37.0 bits (84), Expect = 0.037
 Identities = 28/79 (35%), Positives = 32/79 (40%), Gaps = 14/79 (17%)

Query: 5  ALLLAALAALALAREPPAAPCPARCDVSRCPSP-------RCPGGYVPDLCNCCLVCAAS 57
          ALLLAA    +L  E    P  +   ++RC  P       R PG      C CC  CA  
Sbjct: 9  ALLLAAGPGPSLGDEAIHCPPCSEEKLARCRPPVGCEELVREPG------CGCCATCALG 62

Query: 58 EGEPCGGPLDSPCGESLEC 76
           G PC G     CG  L C
Sbjct: 63 LGMPC-GVYTPRCGSGLRC 80


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,242,355
Number of Sequences: 37866
Number of extensions: 925690
Number of successful extensions: 3246
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 85
Number of HSP's that attempted gapping in prelim test: 3014
Number of HSP's gapped (non-prelim): 296
length of query: 453
length of database: 18,247,518
effective HSP length: 106
effective length of query: 347
effective length of database: 14,233,722
effective search space: 4939101534
effective search space used: 4939101534
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.