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Search of human proteins with 221219004
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221219004 WD repeat domain 74 [Homo sapiens]
(385 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221219004 WD repeat domain 74 [Homo sapiens] 800 0.0
gi|13376840 WD repeat domain 61 [Homo sapiens] 51 2e-06
gi|21071067 TBP-associated factor 5 [Homo sapiens] 42 0.001
gi|45594312 TNF receptor-associated factor 7 [Homo sapiens] 41 0.002
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 40 0.004
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 40 0.004
gi|223005862 echinoderm microtubule associated protein like 6 [H... 39 0.008
gi|22094987 raptor isoform 1 [Homo sapiens] 39 0.008
gi|251823858 raptor isoform 2 [Homo sapiens] 39 0.008
gi|157384986 transducin-like enhancer protein 3 isoform b [Homo ... 39 0.008
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 39 0.008
gi|157384984 transducin-like enhancer protein 3 isoform c [Homo ... 39 0.008
gi|157384982 transducin-like enhancer protein 3 isoform a [Homo ... 39 0.008
gi|38605733 nucleoporin 43kDa [Homo sapiens] 38 0.013
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 38 0.018
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 37 0.023
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 37 0.023
gi|34915994 transducin-like enhancer protein 4 [Homo sapiens] 37 0.023
gi|217330644 WD repeat domain 12 protein [Homo sapiens] 37 0.039
gi|206597470 neural precursor cell expressed, developmentally do... 37 0.039
gi|206597468 neural precursor cell expressed, developmentally do... 37 0.039
gi|23097254 neural precursor cell expressed, developmentally dow... 37 0.039
gi|206597465 neural precursor cell expressed, developmentally do... 37 0.039
gi|34485720 echinoderm microtubule associated protein like 5 [Ho... 37 0.039
gi|21281677 WD repeat domain 36 [Homo sapiens] 36 0.067
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 36 0.067
gi|221219050 transducin-like enhancer protein 2 isoform 3 [Homo ... 36 0.067
gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo ... 36 0.067
gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo s... 36 0.067
gi|24308452 WD repeat domain 85 [Homo sapiens] 36 0.067
>gi|221219004 WD repeat domain 74 [Homo sapiens]
Length = 385
Score = 800 bits (2066), Expect = 0.0
Identities = 385/385 (100%), Positives = 385/385 (100%)
Query: 1 MAAAAARWNHVWVGTETGILKGVNLQRKQAANFTAGGQPRREEAVSALCWGTGGETQMLV 60
MAAAAARWNHVWVGTETGILKGVNLQRKQAANFTAGGQPRREEAVSALCWGTGGETQMLV
Sbjct: 1 MAAAAARWNHVWVGTETGILKGVNLQRKQAANFTAGGQPRREEAVSALCWGTGGETQMLV 60
Query: 61 GCADRTVKHFSTEDGIFQGQRHCPGGEGMFRGLAQADGTLITCVDSGILRVWHDKDKDTS 120
GCADRTVKHFSTEDGIFQGQRHCPGGEGMFRGLAQADGTLITCVDSGILRVWHDKDKDTS
Sbjct: 61 GCADRTVKHFSTEDGIFQGQRHCPGGEGMFRGLAQADGTLITCVDSGILRVWHDKDKDTS 120
Query: 121 SDPLLELRVGPGVCRMRQDPAHPHVVATGGKENALKIWDLQGSEEPVFRAKNVRNDWLDL 180
SDPLLELRVGPGVCRMRQDPAHPHVVATGGKENALKIWDLQGSEEPVFRAKNVRNDWLDL
Sbjct: 121 SDPLLELRVGPGVCRMRQDPAHPHVVATGGKENALKIWDLQGSEEPVFRAKNVRNDWLDL 180
Query: 181 RVPIWDQDIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGN 240
RVPIWDQDIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGN
Sbjct: 181 RVPIWDQDIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGN 240
Query: 241 SVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQN 300
SVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQN
Sbjct: 241 SVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQN 300
Query: 301 PRGLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQEPNKVPLEDTETDELWASLEAAAKRKL 360
PRGLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQEPNKVPLEDTETDELWASLEAAAKRKL
Sbjct: 301 PRGLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQEPNKVPLEDTETDELWASLEAAAKRKL 360
Query: 361 SGLEQPQGALQTRRRKKKRPGSTSP 385
SGLEQPQGALQTRRRKKKRPGSTSP
Sbjct: 361 SGLEQPQGALQTRRRKKKRPGSTSP 385
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 50.8 bits (120), Expect = 2e-06
Identities = 50/203 (24%), Positives = 95/203 (46%), Gaps = 16/203 (7%)
Query: 99 TLITCVDSGILRVWHDKDKDTSSDPLLELRVGPGVCRMRQDPAHPHVVATGGKENA-LKI 157
T++T +++VW +D+ LE G + + D +H +A +A +++
Sbjct: 34 TVVTGSLDDLVKVWKWRDERLDLQWSLE---GHQLGVVSVDISHTLPIAASSSLDAHIRL 90
Query: 158 WDLQGSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQKLVTCTGYHQVRVYDPASPQR 217
WDL+ ++ K++ +D W + F P SQ L T T +V ++ S ++
Sbjct: 91 WDLENGKQ----IKSIDAGPVDA----WT--LAFSPDSQYLATGTHVGKVNIFGVESGKK 140
Query: 218 RPVLETTYGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQC 277
L+T G++ L+ + +P G + G G + D+ G+LL L+G A +R L
Sbjct: 141 EYSLDTR-GKFILS-IAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTF 198
Query: 278 HPSKPLLASCGLDRVLRIHRIQN 300
P LL + D ++I+ +Q+
Sbjct: 199 SPDSQLLVTASDDGYIKIYDVQH 221
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 41.6 bits (96), Expect = 0.001
Identities = 28/106 (26%), Positives = 51/106 (48%), Gaps = 2/106 (1%)
Query: 190 QFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNTHG 249
+F P S + T + VR++D + + G P+ ++T +P G + G T G
Sbjct: 634 RFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKG--PIHSLTFSPNGRFLATGATDG 691
Query: 250 QLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRI 295
++ D+ G ++G LKG +V L+ +LAS +D +R+
Sbjct: 692 RVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRL 737
>gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
Length = 670
Score = 41.2 bits (95), Expect = 0.002
Identities = 39/160 (24%), Positives = 66/160 (41%), Gaps = 19/160 (11%)
Query: 144 HVVATGGKENALKIWDLQGSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQKLVTCTG 203
H V G A+K+WD+ G+E + + N W ++ L +Q +
Sbjct: 489 HNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHW-----------VRALVAAQSYLYSGS 537
Query: 204 YHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNTHGQLAEI-DLRQGRLL 262
Y ++++D + VL+T+ G A+T N IV T+ L + D+ +
Sbjct: 538 YQTIKIWDIRTLDCIHVLQTSGGSVYSIAVT-----NHHIVCGTYENLIHVWDIESKEQV 592
Query: 263 GCLKGLAGSVRGLQ--CHPSKPLLASCGLDRVLRIHRIQN 300
L G G+V L P + + S DR LR+ + N
Sbjct: 593 RTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDN 632
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 40.0 bits (92), Expect = 0.004
Identities = 44/193 (22%), Positives = 83/193 (43%), Gaps = 21/193 (10%)
Query: 106 SGILRVWHDKDKDTSSDPLLELRVG--PGVCRMRQDPAHPHVVATGGKENALKIWDLQGS 163
SG +RVW D + +L +G +C + P + VA+G ++ +K+WD++
Sbjct: 84 SGSIRVW-----DLEAAKILRTLMGHKANICSLDFHP-YGEFVASGSQDTNIKLWDIR-R 136
Query: 164 EEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLET 223
+ VFR + LR F P + L + H V+++D + +
Sbjct: 137 KGCVFRYRGHSQAVRCLR---------FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG 187
Query: 224 TYGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPL 283
G P+ + P + G++ + DL + +++ C++G G VR + +P
Sbjct: 188 HTG--PVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCC 245
Query: 284 LASCGLDRVLRIH 296
L S G LR++
Sbjct: 246 LYS-GCQDSLRVY 257
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 40.0 bits (92), Expect = 0.004
Identities = 40/160 (25%), Positives = 69/160 (43%), Gaps = 16/160 (10%)
Query: 146 VATGGKENALKIWDLQGSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQKLVTCTGYH 205
+ +GG +N +K+WDL+ + + + + L + GS L +
Sbjct: 208 IISGGIDNDIKVWDLR-QNKLTYTMRGHADSVTGLSLSS--------EGSYLLSNAMD-N 257
Query: 206 QVRVYD--PASPQRRPVL----ETTYGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQG 259
VRV+D P +P+ R V E L + +P G+ + G+ + D
Sbjct: 258 TVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSR 317
Query: 260 RLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQ 299
R+L L G AGS+ + HP +P++ S D+ L + IQ
Sbjct: 318 RILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
>gi|223005862 echinoderm microtubule associated protein like 6 [Homo
sapiens]
Length = 1958
Score = 38.9 bits (89), Expect = 0.008
Identities = 22/62 (35%), Positives = 36/62 (58%), Gaps = 2/62 (3%)
Query: 235 LTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKG-LAGSVRGLQCHPSKPLLASCGLDRVL 293
+T G ++VG +G++ EID + G + ++G + G V GL HP P+ A+ D+ L
Sbjct: 964 ITLGHGHILVGTKNGEILEID-KSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTL 1022
Query: 294 RI 295
RI
Sbjct: 1023 RI 1024
>gi|22094987 raptor isoform 1 [Homo sapiens]
Length = 1335
Score = 38.9 bits (89), Expect = 0.008
Identities = 48/223 (21%), Positives = 91/223 (40%), Gaps = 24/223 (10%)
Query: 86 GEGMFRGLAQADGTLITCVDSGILRVWHDKDKDTSSDPLLELRVGPGVC-RMRQDPAHPH 144
G GM Q G L++ D I+R+W D D++ + ++ G C +H
Sbjct: 1124 GAGMVVDWEQETGLLMSSGDVRIVRIW-DTDREMK---VQDIPTGADSCVTSLSCDSHRS 1179
Query: 145 VVATGGKENALKIWDLQ-GSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQKLVTCTG 203
++ G + +++++D + E W + +Q P +V+ +
Sbjct: 1180 LIVAGLGDGSIRVYDRRMALSECRVMTYREHTAW------VVKASLQKRPDGH-IVSVSV 1232
Query: 204 YHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLL- 262
VR++DP P+ VL+ G LTA+ + P + + G+ + Q I G L+
Sbjct: 1233 NGDVRIFDPRMPESVNVLQIVKG---LTALDIHPQADLIACGSVN-QFTAIYNSSGELIN 1288
Query: 263 ------GCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQ 299
G + G++ L HP P LA D + ++ ++
Sbjct: 1289 NIKYYDGFMGQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVE 1331
>gi|251823858 raptor isoform 2 [Homo sapiens]
Length = 1177
Score = 38.9 bits (89), Expect = 0.008
Identities = 48/223 (21%), Positives = 91/223 (40%), Gaps = 24/223 (10%)
Query: 86 GEGMFRGLAQADGTLITCVDSGILRVWHDKDKDTSSDPLLELRVGPGVC-RMRQDPAHPH 144
G GM Q G L++ D I+R+W D D++ + ++ G C +H
Sbjct: 966 GAGMVVDWEQETGLLMSSGDVRIVRIW-DTDREMK---VQDIPTGADSCVTSLSCDSHRS 1021
Query: 145 VVATGGKENALKIWDLQ-GSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQKLVTCTG 203
++ G + +++++D + E W + +Q P +V+ +
Sbjct: 1022 LIVAGLGDGSIRVYDRRMALSECRVMTYREHTAW------VVKASLQKRPDGH-IVSVSV 1074
Query: 204 YHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLL- 262
VR++DP P+ VL+ G LTA+ + P + + G+ + Q I G L+
Sbjct: 1075 NGDVRIFDPRMPESVNVLQIVKG---LTALDIHPQADLIACGSVN-QFTAIYNSSGELIN 1130
Query: 263 ------GCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQ 299
G + G++ L HP P LA D + ++ ++
Sbjct: 1131 NIKYYDGFMGQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVE 1173
>gi|157384986 transducin-like enhancer protein 3 isoform b [Homo
sapiens]
Length = 769
Score = 38.9 bits (89), Expect = 0.008
Identities = 42/178 (23%), Positives = 70/178 (39%), Gaps = 11/178 (6%)
Query: 130 GPGVCRMRQDPAHPHVVATGGKENALKIWDLQ--GSEEPVFRAKNVRNDWLDLRVPIWDQ 187
G VC + HV TGGK +KIWD+ GS+ P+ + + D + +
Sbjct: 483 GEVVCAVTISNPTRHVY-TGGK-GCVKIWDISQPGSKSPISQLDCLNRD-------NYIR 533
Query: 188 DIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNT 247
+ LP + L+ + ++D ASP R E T A+ ++P +
Sbjct: 534 SCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCS 593
Query: 248 HGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPRGLE 305
G +A DL L+ +G + L + GLD +R ++ R L+
Sbjct: 594 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQ 651
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 38.9 bits (89), Expect = 0.008
Identities = 29/112 (25%), Positives = 50/112 (44%), Gaps = 2/112 (1%)
Query: 189 IQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNTH 248
++F P S L T + VR++ ++ Q V T P+ ++ +P G +
Sbjct: 432 VKFHPNSNYLATGSTDKTVRLW--SAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGED 489
Query: 249 GQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQN 300
+L DL G L L+G ++ L P L+AS +D +R+ I+N
Sbjct: 490 QRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
>gi|157384984 transducin-like enhancer protein 3 isoform c [Homo
sapiens]
Length = 760
Score = 38.9 bits (89), Expect = 0.008
Identities = 42/178 (23%), Positives = 70/178 (39%), Gaps = 11/178 (6%)
Query: 130 GPGVCRMRQDPAHPHVVATGGKENALKIWDLQ--GSEEPVFRAKNVRNDWLDLRVPIWDQ 187
G VC + HV TGGK +KIWD+ GS+ P+ + + D + +
Sbjct: 474 GEVVCAVTISNPTRHVY-TGGK-GCVKIWDISQPGSKSPISQLDCLNRD-------NYIR 524
Query: 188 DIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNT 247
+ LP + L+ + ++D ASP R E T A+ ++P +
Sbjct: 525 SCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCS 584
Query: 248 HGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPRGLE 305
G +A DL L+ +G + L + GLD +R ++ R L+
Sbjct: 585 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQ 642
>gi|157384982 transducin-like enhancer protein 3 isoform a [Homo
sapiens]
Length = 772
Score = 38.9 bits (89), Expect = 0.008
Identities = 42/178 (23%), Positives = 70/178 (39%), Gaps = 11/178 (6%)
Query: 130 GPGVCRMRQDPAHPHVVATGGKENALKIWDLQ--GSEEPVFRAKNVRNDWLDLRVPIWDQ 187
G VC + HV TGGK +KIWD+ GS+ P+ + + D + +
Sbjct: 486 GEVVCAVTISNPTRHVY-TGGK-GCVKIWDISQPGSKSPISQLDCLNRD-------NYIR 536
Query: 188 DIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNT 247
+ LP + L+ + ++D ASP R E T A+ ++P +
Sbjct: 537 SCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCS 596
Query: 248 HGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPRGLE 305
G +A DL L+ +G + L + GLD +R ++ R L+
Sbjct: 597 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQ 654
>gi|38605733 nucleoporin 43kDa [Homo sapiens]
Length = 380
Score = 38.1 bits (87), Expect = 0.013
Identities = 25/71 (35%), Positives = 36/71 (50%), Gaps = 5/71 (7%)
Query: 100 LITCVDSGILRVWHDKDKDTSSDPLLEL---RVGPGVCRMRQDPAHPHVVATGGKENALK 156
++T G L++W + + +L L RV P C R P HVVATGG++ L
Sbjct: 186 ILTVNSIGQLKIWDFRQQGNEPSQILSLTGDRV-PLHCVDRH-PNQQHVVATGGQDGMLS 243
Query: 157 IWDLQGSEEPV 167
IWD++ PV
Sbjct: 244 IWDVRQGTMPV 254
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 37.7 bits (86), Expect = 0.018
Identities = 35/152 (23%), Positives = 62/152 (40%), Gaps = 13/152 (8%)
Query: 145 VVATGGKENALKIWDLQGSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQKLVTCTGY 204
+ TGG + ++WDL+ +F +++ + I F P + T +G
Sbjct: 379 LAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIY----------GINFSPNGYHIATGSGD 428
Query: 205 HQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQG-RLLG 263
+ +V+D QRR V + +T + P + ++ + A+I G L
Sbjct: 429 NTCKVWDLR--QRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLK 486
Query: 264 CLKGLAGSVRGLQCHPSKPLLASCGLDRVLRI 295
L G G V GL L+A+C DR ++
Sbjct: 487 TLAGHEGKVMGLDISSDGQLIATCSYDRTFKL 518
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 37.4 bits (85), Expect = 0.023
Identities = 52/263 (19%), Positives = 99/263 (37%), Gaps = 49/263 (18%)
Query: 84 PGGEGMFRGLAQADGTLITCVDSGI-------------LRVWHDKDKDTS------SDPL 124
P E F+G A +TCVD I L VWH K + + D +
Sbjct: 9 PSLERHFKGHRDA----VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAV 64
Query: 125 LELRVGPGVCRMRQDPAHPHVVATGGKENALKIW--DLQGSEEPVFRAKNVRNDWLDLRV 182
+ P H++A+G ++ ++IW +++G E VFRA
Sbjct: 65 TCVNFSPS----------GHLLASGSRDKTVRIWVPNVKG-ESTVFRAHTATV------- 106
Query: 183 PIWDQDIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSV 242
+ + F Q VT + V+V+ A+ +++ + + + +P G +
Sbjct: 107 ----RSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLI 160
Query: 243 IVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPR 302
+ + + D + G V + HPS +A+ G+D +++ ++ R
Sbjct: 161 VSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR 220
Query: 303 GLEHKVYLKSQLNCLLLSGRDNW 325
L+H + +N L N+
Sbjct: 221 LLQHYQLHSAAVNGLSFHPSGNY 243
Score = 30.4 bits (67), Expect = 2.8
Identities = 18/66 (27%), Positives = 30/66 (45%)
Query: 230 LTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGL 289
+ ++ P GN +I ++ L +DL +GRLL L G G + + AS G
Sbjct: 232 VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291
Query: 290 DRVLRI 295
D + +
Sbjct: 292 DEQVMV 297
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 37.4 bits (85), Expect = 0.023
Identities = 52/263 (19%), Positives = 99/263 (37%), Gaps = 49/263 (18%)
Query: 84 PGGEGMFRGLAQADGTLITCVDSGI-------------LRVWHDKDKDTS------SDPL 124
P E F+G A +TCVD I L VWH K + + D +
Sbjct: 9 PSLERHFKGHRDA----VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAV 64
Query: 125 LELRVGPGVCRMRQDPAHPHVVATGGKENALKIW--DLQGSEEPVFRAKNVRNDWLDLRV 182
+ P H++A+G ++ ++IW +++G E VFRA
Sbjct: 65 TCVNFSPS----------GHLLASGSRDKTVRIWVPNVKG-ESTVFRAHTATV------- 106
Query: 183 PIWDQDIQFLPGSQKLVTCTGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSV 242
+ + F Q VT + V+V+ A+ +++ + + + +P G +
Sbjct: 107 ----RSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLI 160
Query: 243 IVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPR 302
+ + + D + G V + HPS +A+ G+D +++ ++ R
Sbjct: 161 VSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHR 220
Query: 303 GLEHKVYLKSQLNCLLLSGRDNW 325
L+H + +N L N+
Sbjct: 221 LLQHYQLHSAAVNGLSFHPSGNY 243
Score = 31.2 bits (69), Expect = 1.6
Identities = 32/133 (24%), Positives = 53/133 (39%), Gaps = 15/133 (11%)
Query: 230 LTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGL 289
+ ++ P GN +I ++ L +DL +GRLL L G G + + AS G
Sbjct: 232 VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291
Query: 290 DRVLRIHRI--------------QNPRGLEHKVYLKSQLNCLLLSGRD-NWEDEPQEPQE 334
D + + + + P L + +++ + GR + E +PQE
Sbjct: 292 DEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSVESVQSQPQE 351
Query: 335 PNKVPLEDTETDE 347
P VP T T E
Sbjct: 352 PVSVPQTLTSTLE 364
>gi|34915994 transducin-like enhancer protein 4 [Homo sapiens]
Length = 773
Score = 37.4 bits (85), Expect = 0.023
Identities = 52/231 (22%), Positives = 88/231 (38%), Gaps = 27/231 (11%)
Query: 84 PGGEGMFRGLAQADGTLI-------TCVDSGILRVWHDKDKDTSSDPLLELRVGPGVCRM 136
PGG+ + ADG + + GI R H + +T L G VC +
Sbjct: 443 PGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPR--HARQINT-------LNHGEVVCAV 493
Query: 137 RQDPAHPHVVATGGKENALKIWDLQ--GSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPG 194
HV TGGK +K+WD+ G++ PV + + D + + + LP
Sbjct: 494 TISNPTRHVY-TGGK-GCVKVWDISHPGNKSPVSQLDCLNRD-------NYIRSCRLLPD 544
Query: 195 SQKLVTCTGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNTHGQLAEI 254
+ L+ + ++D A+P R E T A+ ++P + G +A
Sbjct: 545 GRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVW 604
Query: 255 DLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPRGLE 305
DL L+ +G + L + GLD +R ++ R L+
Sbjct: 605 DLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 655
>gi|217330644 WD repeat domain 12 protein [Homo sapiens]
Length = 423
Score = 36.6 bits (83), Expect = 0.039
Identities = 34/146 (23%), Positives = 61/146 (41%), Gaps = 16/146 (10%)
Query: 43 EAVSALCWGTGGETQMLVGCADRTVKHFSTEDGIFQGQRHCPGGEGMFRGLAQADGTLIT 102
EAVS++ W E + D T++ + E G + G +F ++ + L
Sbjct: 258 EAVSSVLWSDAEE--ICSASWDHTIRVWDVESGSLKSTLT---GNKVFNCISYSP--LCK 310
Query: 103 CVDSGI----LRVWHDKDKDTSSDPLLELRVGPGVCRMRQDPAHPHVVATGGKENALKIW 158
+ SG +R+W + KD S L V ++ P H + +G +N +K+W
Sbjct: 311 RLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLW 370
Query: 159 DLQGSEEPVF-----RAKNVRNDWLD 179
D + + P++ K + DW D
Sbjct: 371 DTRSCKAPLYDLAAHEDKVLSVDWTD 396
>gi|206597470 neural precursor cell expressed, developmentally
down-regulated 1 isoform c [Homo sapiens]
Length = 571
Score = 36.6 bits (83), Expect = 0.039
Identities = 24/90 (26%), Positives = 48/90 (53%), Gaps = 6/90 (6%)
Query: 189 IQFLPGSQKLVTCTGYHQ-VRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNT 247
I F P ++ L G + + +YD +S + +++T + PLTA+ P G ++ +G++
Sbjct: 123 ICFSPVNELLFVTIGLDKRIILYDTSS---KKLVKTLVADTPLTAVDFMPDGATLAIGSS 179
Query: 248 HGQLAEIDLRQGRLLGCLKGLAGSVRGLQC 277
G++ + DLR L +K ++ +QC
Sbjct: 180 RGKIYQYDLRM--LKSPVKTISAHKTSVQC 207
>gi|206597468 neural precursor cell expressed, developmentally
down-regulated 1 isoform b [Homo sapiens]
Length = 660
Score = 36.6 bits (83), Expect = 0.039
Identities = 24/90 (26%), Positives = 48/90 (53%), Gaps = 6/90 (6%)
Query: 189 IQFLPGSQKLVTCTGYHQ-VRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNT 247
I F P ++ L G + + +YD +S + +++T + PLTA+ P G ++ +G++
Sbjct: 212 ICFSPVNELLFVTIGLDKRIILYDTSS---KKLVKTLVADTPLTAVDFMPDGATLAIGSS 268
Query: 248 HGQLAEIDLRQGRLLGCLKGLAGSVRGLQC 277
G++ + DLR L +K ++ +QC
Sbjct: 269 RGKIYQYDLRM--LKSPVKTISAHKTSVQC 296
>gi|23097254 neural precursor cell expressed, developmentally
down-regulated 1 isoform b [Homo sapiens]
Length = 660
Score = 36.6 bits (83), Expect = 0.039
Identities = 24/90 (26%), Positives = 48/90 (53%), Gaps = 6/90 (6%)
Query: 189 IQFLPGSQKLVTCTGYHQ-VRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNT 247
I F P ++ L G + + +YD +S + +++T + PLTA+ P G ++ +G++
Sbjct: 212 ICFSPVNELLFVTIGLDKRIILYDTSS---KKLVKTLVADTPLTAVDFMPDGATLAIGSS 268
Query: 248 HGQLAEIDLRQGRLLGCLKGLAGSVRGLQC 277
G++ + DLR L +K ++ +QC
Sbjct: 269 RGKIYQYDLRM--LKSPVKTISAHKTSVQC 296
>gi|206597465 neural precursor cell expressed, developmentally
down-regulated 1 isoform a [Homo sapiens]
Length = 667
Score = 36.6 bits (83), Expect = 0.039
Identities = 24/90 (26%), Positives = 48/90 (53%), Gaps = 6/90 (6%)
Query: 189 IQFLPGSQKLVTCTGYHQ-VRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNT 247
I F P ++ L G + + +YD +S + +++T + PLTA+ P G ++ +G++
Sbjct: 219 ICFSPVNELLFVTIGLDKRIILYDTSS---KKLVKTLVADTPLTAVDFMPDGATLAIGSS 275
Query: 248 HGQLAEIDLRQGRLLGCLKGLAGSVRGLQC 277
G++ + DLR L +K ++ +QC
Sbjct: 276 RGKIYQYDLRM--LKSPVKTISAHKTSVQC 303
>gi|34485720 echinoderm microtubule associated protein like 5 [Homo
sapiens]
Length = 1977
Score = 36.6 bits (83), Expect = 0.039
Identities = 20/59 (33%), Positives = 34/59 (57%), Gaps = 2/59 (3%)
Query: 238 GGNSVIVGNTHGQLAEIDLRQGRLLGCLKG-LAGSVRGLQCHPSKPLLASCGLDRVLRI 295
G ++VG +G++ E+D + G + ++G + G V GL HP P+ A+ D+ LRI
Sbjct: 967 GHGHILVGTKNGEILEVD-KSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRI 1024
Score = 29.6 bits (65), Expect = 4.8
Identities = 21/76 (27%), Positives = 39/76 (51%), Gaps = 2/76 (2%)
Query: 222 ETTYGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQ-GRLLGCLKG-LAGSVRGLQCHP 279
ET G L+ ++ G+ ++VG ++ EI +++ + ++G G + L HP
Sbjct: 276 ETDQGYKGLSVRSVCWRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHP 335
Query: 280 SKPLLASCGLDRVLRI 295
+KPL + DR +RI
Sbjct: 336 TKPLAVTGSDDRSVRI 351
>gi|21281677 WD repeat domain 36 [Homo sapiens]
Length = 951
Score = 35.8 bits (81), Expect = 0.067
Identities = 49/217 (22%), Positives = 88/217 (40%), Gaps = 26/217 (11%)
Query: 95 QADGTLITCVDS-GILRVWHDKDKDTSSDPLLELRVGPGVCRMRQDPAHPHV----VATG 149
Q G I VD+ GIL +WH S + L+L V ++ HP + G
Sbjct: 169 QPFGDHIISVDTDGILIIWHIY----SEEEYLQLTFDKSVFKISAI-LHPSTYLNKILLG 223
Query: 150 GKENALKIWDLQGSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQKL-VTCTGYHQVR 208
++ +L++W NV+++ L P W + L + + V G +
Sbjct: 224 SEQGSLQLW-------------NVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQ 270
Query: 209 VYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIV-GNTHGQLAEIDLRQGRLLGCLKG 267
V +++ P+T+++ G+ V+ G+ G + DL +L+ ++
Sbjct: 271 VIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRN 330
Query: 268 L-AGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPRG 303
+ ++ GL +PLL + G D LRI P G
Sbjct: 331 AHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGPTG 367
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 35.8 bits (81), Expect = 0.067
Identities = 35/184 (19%), Positives = 76/184 (41%), Gaps = 16/184 (8%)
Query: 144 HVVATGGKENALKIW--DLQGSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQKLVTC 201
H++A+G ++ ++IW +++G E VFRA + + F Q VT
Sbjct: 36 HLLASGSRDKTVRIWVPNVKG-ESTVFRAHTATV-----------RSVHFCSDGQSFVTA 83
Query: 202 TGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRL 261
+ V+V+ A+ +++ + + + +P G ++ + + D
Sbjct: 84 SDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 141
Query: 262 LGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPRGLEHKVYLKSQLNCLLLSG 321
+ G V + HPS +A+ G+D +++ ++ R L+H + +N L
Sbjct: 142 VHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP 201
Query: 322 RDNW 325
N+
Sbjct: 202 SGNY 205
Score = 31.2 bits (69), Expect = 1.6
Identities = 32/133 (24%), Positives = 53/133 (39%), Gaps = 15/133 (11%)
Query: 230 LTAMTLTPGGNSVIVGNTHGQLAEIDLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGL 289
+ ++ P GN +I ++ L +DL +GRLL L G G + + AS G
Sbjct: 194 VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 253
Query: 290 DRVLRIHRI--------------QNPRGLEHKVYLKSQLNCLLLSGRD-NWEDEPQEPQE 334
D + + + + P L + +++ + GR + E +PQE
Sbjct: 254 DEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSVESVQSQPQE 313
Query: 335 PNKVPLEDTETDE 347
P VP T T E
Sbjct: 314 PVSVPQTLTSTLE 326
>gi|221219050 transducin-like enhancer protein 2 isoform 3 [Homo
sapiens]
Length = 621
Score = 35.8 bits (81), Expect = 0.067
Identities = 51/231 (22%), Positives = 89/231 (38%), Gaps = 27/231 (11%)
Query: 84 PGGEGMFRGLAQADGTLI-------TCVDSGILRVWHDKDKDTSSDPLLELRVGPGVCRM 136
PGG+ + ADG + V +GI R H + T L G VC +
Sbjct: 291 PGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPR--HARQLHT-------LAHGEVVCAV 341
Query: 137 RQDPAHPHVVATGGKENALKIWDL--QGSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPG 194
+ HV TGGK +K+WD+ G++ PV + + D + + + LP
Sbjct: 342 TISGSTQHVY-TGGK-GCVKVWDVGQPGAKTPVAQLDCLNRD-------NYIRSCKLLPD 392
Query: 195 SQKLVTCTGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNTHGQLAEI 254
+ L+ + ++D A+P R E T A+ ++P + G +
Sbjct: 393 GRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVW 452
Query: 255 DLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPRGLE 305
DL+ ++ +G + L + GLD +R ++ R L+
Sbjct: 453 DLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQ 503
>gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo
sapiens]
Length = 706
Score = 35.8 bits (81), Expect = 0.067
Identities = 51/231 (22%), Positives = 89/231 (38%), Gaps = 27/231 (11%)
Query: 84 PGGEGMFRGLAQADGTLI-------TCVDSGILRVWHDKDKDTSSDPLLELRVGPGVCRM 136
PGG+ + ADG + V +GI R H + T L G VC +
Sbjct: 427 PGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPR--HARQLHT-------LAHGEVVCAV 477
Query: 137 RQDPAHPHVVATGGKENALKIWDL--QGSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPG 194
+ HV TGGK +K+WD+ G++ PV + + D + + + LP
Sbjct: 478 TISGSTQHVY-TGGK-GCVKVWDVGQPGAKTPVAQLDCLNRD-------NYIRSCKLLPD 528
Query: 195 SQKLVTCTGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNTHGQLAEI 254
+ L+ + ++D A+P R E T A+ ++P + G +
Sbjct: 529 GRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVW 588
Query: 255 DLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPRGLE 305
DL+ ++ +G + L + GLD +R ++ R L+
Sbjct: 589 DLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQ 639
>gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo
sapiens]
Length = 743
Score = 35.8 bits (81), Expect = 0.067
Identities = 51/231 (22%), Positives = 89/231 (38%), Gaps = 27/231 (11%)
Query: 84 PGGEGMFRGLAQADGTLI-------TCVDSGILRVWHDKDKDTSSDPLLELRVGPGVCRM 136
PGG+ + ADG + V +GI R H + T L G VC +
Sbjct: 413 PGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPR--HARQLHT-------LAHGEVVCAV 463
Query: 137 RQDPAHPHVVATGGKENALKIWDL--QGSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPG 194
+ HV TGGK +K+WD+ G++ PV + + D + + + LP
Sbjct: 464 TISGSTQHVY-TGGK-GCVKVWDVGQPGAKTPVAQLDCLNRD-------NYIRSCKLLPD 514
Query: 195 SQKLVTCTGYHQVRVYDPASPQRRPVLETTYGEYPLTAMTLTPGGNSVIVGNTHGQLAEI 254
+ L+ + ++D A+P R E T A+ ++P + G +
Sbjct: 515 GRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVW 574
Query: 255 DLRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIQNPRGLE 305
DL+ ++ +G + L + GLD +R ++ R L+
Sbjct: 575 DLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQ 625
>gi|24308452 WD repeat domain 85 [Homo sapiens]
Length = 452
Score = 35.8 bits (81), Expect = 0.067
Identities = 17/63 (26%), Positives = 30/63 (47%), Gaps = 2/63 (3%)
Query: 105 DSGILRVWHDKDKDTSSDPLLELRVGPGVCRMRQDPAHPHVVATGGKENALKIWDLQGSE 164
D G+LR W + R GVC ++ P H++ATG + + +WD + +
Sbjct: 216 DDGLLRGWDTRVPGKFL--FTSKRHTMGVCSIQSSPHREHILATGSYDEHILLWDTRNMK 273
Query: 165 EPV 167
+P+
Sbjct: 274 QPL 276
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,923,194
Number of Sequences: 37866
Number of extensions: 819508
Number of successful extensions: 2640
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 82
Number of HSP's that attempted gapping in prelim test: 2454
Number of HSP's gapped (non-prelim): 252
length of query: 385
length of database: 18,247,518
effective HSP length: 104
effective length of query: 281
effective length of database: 14,309,454
effective search space: 4020956574
effective search space used: 4020956574
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.