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Search of human proteins with 218749837
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|218749837 SMAD family member 6 isoform 2 [Homo sapiens]
(235 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|218749837 SMAD family member 6 isoform 2 [Homo sapiens] 494 e-140
gi|92859871 SMAD family member 6 isoform 1 [Homo sapiens] 471 e-133
gi|5174517 SMAD family member 7 [Homo sapiens] 247 7e-66
gi|51173730 Sma- and Mad-related protein 2 isoform 1 [Homo sapiens] 105 4e-23
gi|5174511 Sma- and Mad-related protein 2 isoform 1 [Homo sapiens] 105 4e-23
gi|209693426 Sma- and Mad-related protein 2 isoform 2 [Homo sapi... 105 4e-23
gi|5174513 mothers against decapentaplegic homolog 3 isoform 1 [... 101 5e-22
gi|223029442 mothers against decapentaplegic homolog 3 isoform 3... 101 5e-22
gi|223029440 mothers against decapentaplegic homolog 3 isoform 2... 101 5e-22
gi|5174519 SMAD family member 9 isoform b [Homo sapiens] 100 2e-21
gi|223029444 mothers against decapentaplegic homolog 3 isoform 4... 100 2e-21
gi|4885457 mothers against decapentaplegic homolog 4 [Homo sapiens] 99 3e-21
gi|187828357 SMAD family member 9 isoform a [Homo sapiens] 97 2e-20
gi|51173727 Sma- and Mad-related protein 1 [Homo sapiens] 96 3e-20
gi|5174509 Sma- and Mad-related protein 1 [Homo sapiens] 96 3e-20
gi|47778931 SMAD, mothers against DPP homolog 5 [Homo sapiens] 96 3e-20
gi|47778929 SMAD, mothers against DPP homolog 5 [Homo sapiens] 96 3e-20
gi|47778925 SMAD, mothers against DPP homolog 5 [Homo sapiens] 96 3e-20
gi|124256489 crooked neck-like 1 protein [Homo sapiens] 32 0.62
gi|22538426 TRAF3 interacting protein 2 isoform 1 [Homo sapiens] 30 1.8
gi|22538428 TRAF3 interacting protein 2 isoform 2 [Homo sapiens] 30 1.8
gi|187761317 tet oncogene family member 2 isoform a [Homo sapiens] 30 2.3
gi|239757409 PREDICTED: similar to zinc finger protein 208 [Homo... 30 2.3
gi|239746371 PREDICTED: similar to zinc finger protein 208 [Homo... 30 2.3
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 30 2.3
gi|37059810 ring finger protein 212 isoform b [Homo sapiens] 29 3.1
gi|10047138 NADH:ubiquinone oxidoreductase MLRQ subunit homolog ... 29 3.1
gi|134254450 patched isoform S [Homo sapiens] 28 5.2
gi|134254435 patched isoform S [Homo sapiens] 28 5.2
gi|134254468 patched isoform S [Homo sapiens] 28 5.2
>gi|218749837 SMAD family member 6 isoform 2 [Homo sapiens]
Length = 235
Score = 494 bits (1273), Expect = e-140
Identities = 235/235 (100%), Positives = 235/235 (100%)
Query: 1 MSRMGKPIETQKSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASM 60
MSRMGKPIETQKSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASM
Sbjct: 1 MSRMGKPIETQKSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASM 60
Query: 61 SPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVR 120
SPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVR
Sbjct: 61 SPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVR 120
Query: 121 RTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDF 180
RTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDF
Sbjct: 121 RTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDF 180
Query: 181 ERSGLQHAPEPDAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR 235
ERSGLQHAPEPDAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR
Sbjct: 181 ERSGLQHAPEPDAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR 235
>gi|92859871 SMAD family member 6 isoform 1 [Homo sapiens]
Length = 496
Score = 471 bits (1213), Expect = e-133
Identities = 223/224 (99%), Positives = 224/224 (100%)
Query: 12 KSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWC 71
+SPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWC
Sbjct: 273 ESPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWC 332
Query: 72 SVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGIL 131
SVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGIL
Sbjct: 333 SVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGIL 392
Query: 132 LSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLQHAPEP 191
LSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLQHAPEP
Sbjct: 393 LSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLQHAPEP 452
Query: 192 DAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR 235
DAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR
Sbjct: 453 DAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR 496
>gi|5174517 SMAD family member 7 [Homo sapiens]
Length = 426
Score = 247 bits (630), Expect = 7e-66
Identities = 122/224 (54%), Positives = 156/224 (69%), Gaps = 5/224 (2%)
Query: 12 KSPPPPYSRLSPRDEYKPL-DLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHW 70
+SPPPPYSR P D KP D D+ S ET TN L APG SD+ + + SHW
Sbjct: 205 ESPPPPYSRY-PMDFLKPTADCPDAVPSSAETGGTNYL--APGGLSDSQLLLEPGDRSHW 261
Query: 71 CSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGI 130
C VAYWE +TRVGRLY V + ++ IFYDLPQG+GFCLGQLN + +S+ V++ RSKIG GI
Sbjct: 262 CVVAYWEEKTRVGRLYCVQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGCGI 321
Query: 131 LLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERS-GLQHAP 189
L++E DGVW YNR +PIF+ S TLD P R L+V KV PG+SIK FD+E++ LQ
Sbjct: 322 QLTREVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPN 381
Query: 190 EPDAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNN 233
+ + P+ +V+ISF KGWG CY+RQFI+SCPCWLE++ N+
Sbjct: 382 DHEFMQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFNS 425
>gi|51173730 Sma- and Mad-related protein 2 isoform 1 [Homo sapiens]
Length = 467
Score = 105 bits (261), Expect = 4e-23
Identities = 72/217 (33%), Positives = 106/217 (48%), Gaps = 20/217 (9%)
Query: 25 DEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGR 84
D P +LS +TLS +SL P +S+ P+ WCS+AY+E RVG
Sbjct: 242 DTGSPAELSPTTLS----PVNHSLDLQPVTYSE---------PAFWCSIAYYELNQRVGE 288
Query: 85 LYAVYDQAVSI--FYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAY 142
+ ++++ F D FCLG L+ R+ +V TR IG G+ L V+A
Sbjct: 289 TFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAE 348
Query: 143 NRGEHPIFVNSPTLDAP-GGRALVVRKVPPGYSIKVFDFERSGLQHAPEPDAA-DGPYDP 200
+ IFV SP + G V K+PPG ++K+F+ + A + + Y
Sbjct: 349 CLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQL 408
Query: 201 N---SVRISFAKGWGPCYSRQFITSCPCWLEILLNNP 234
++R+SF KGWG Y RQ +TS PCW+E+ LN P
Sbjct: 409 TRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGP 445
>gi|5174511 Sma- and Mad-related protein 2 isoform 1 [Homo sapiens]
Length = 467
Score = 105 bits (261), Expect = 4e-23
Identities = 72/217 (33%), Positives = 106/217 (48%), Gaps = 20/217 (9%)
Query: 25 DEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGR 84
D P +LS +TLS +SL P +S+ P+ WCS+AY+E RVG
Sbjct: 242 DTGSPAELSPTTLS----PVNHSLDLQPVTYSE---------PAFWCSIAYYELNQRVGE 288
Query: 85 LYAVYDQAVSI--FYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAY 142
+ ++++ F D FCLG L+ R+ +V TR IG G+ L V+A
Sbjct: 289 TFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAE 348
Query: 143 NRGEHPIFVNSPTLDAP-GGRALVVRKVPPGYSIKVFDFERSGLQHAPEPDAA-DGPYDP 200
+ IFV SP + G V K+PPG ++K+F+ + A + + Y
Sbjct: 349 CLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQL 408
Query: 201 N---SVRISFAKGWGPCYSRQFITSCPCWLEILLNNP 234
++R+SF KGWG Y RQ +TS PCW+E+ LN P
Sbjct: 409 TRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGP 445
>gi|209693426 Sma- and Mad-related protein 2 isoform 2 [Homo
sapiens]
Length = 437
Score = 105 bits (261), Expect = 4e-23
Identities = 72/217 (33%), Positives = 106/217 (48%), Gaps = 20/217 (9%)
Query: 25 DEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGR 84
D P +LS +TLS +SL P +S+ P+ WCS+AY+E RVG
Sbjct: 212 DTGSPAELSPTTLS----PVNHSLDLQPVTYSE---------PAFWCSIAYYELNQRVGE 258
Query: 85 LYAVYDQAVSI--FYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAY 142
+ ++++ F D FCLG L+ R+ +V TR IG G+ L V+A
Sbjct: 259 TFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAE 318
Query: 143 NRGEHPIFVNSPTLDAP-GGRALVVRKVPPGYSIKVFDFERSGLQHAPEPDAA-DGPYDP 200
+ IFV SP + G V K+PPG ++K+F+ + A + + Y
Sbjct: 319 CLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQL 378
Query: 201 N---SVRISFAKGWGPCYSRQFITSCPCWLEILLNNP 234
++R+SF KGWG Y RQ +TS PCW+E+ LN P
Sbjct: 379 TRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGP 415
>gi|5174513 mothers against decapentaplegic homolog 3 isoform 1
[Homo sapiens]
Length = 425
Score = 101 bits (252), Expect = 5e-22
Identities = 74/235 (31%), Positives = 115/235 (48%), Gaps = 21/235 (8%)
Query: 12 KSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDAT-----K 66
++PPP Y LS E SD ++++ + +L +P S A + D +
Sbjct: 178 ETPPPGY--LSEDGE-----TSDHQMNHSMDAGSPNL--SPNPMSPAHNNLDLQPVTYCE 228
Query: 67 PSHWCSVAYWEHRTRVGRLYAVYDQAVSI--FYDLPQGSGFCLGQLNLEQRSESVRRTRS 124
P+ WCS++Y+E RVG + ++++ F D FCLG L+ R+ +V TR
Sbjct: 229 PAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRR 288
Query: 125 KIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAP-GGRALVVRKVPPGYSIKVFDFERS 183
IG G+ L V+A + IFV SP + G V K+PPG ++K+F+ +
Sbjct: 289 HIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEF 348
Query: 184 GLQHAPEPDAA-DGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEILLNNP 234
A + + Y ++R+SF KGWG Y RQ +TS PCW+E+ LN P
Sbjct: 349 AALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGP 403
>gi|223029442 mothers against decapentaplegic homolog 3 isoform 3
[Homo sapiens]
Length = 381
Score = 101 bits (252), Expect = 5e-22
Identities = 74/235 (31%), Positives = 115/235 (48%), Gaps = 21/235 (8%)
Query: 12 KSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDAT-----K 66
++PPP Y LS E SD ++++ + +L +P S A + D +
Sbjct: 134 ETPPPGY--LSEDGE-----TSDHQMNHSMDAGSPNL--SPNPMSPAHNNLDLQPVTYCE 184
Query: 67 PSHWCSVAYWEHRTRVGRLYAVYDQAVSI--FYDLPQGSGFCLGQLNLEQRSESVRRTRS 124
P+ WCS++Y+E RVG + ++++ F D FCLG L+ R+ +V TR
Sbjct: 185 PAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRR 244
Query: 125 KIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAP-GGRALVVRKVPPGYSIKVFDFERS 183
IG G+ L V+A + IFV SP + G V K+PPG ++K+F+ +
Sbjct: 245 HIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEF 304
Query: 184 GLQHAPEPDAA-DGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEILLNNP 234
A + + Y ++R+SF KGWG Y RQ +TS PCW+E+ LN P
Sbjct: 305 AALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGP 359
>gi|223029440 mothers against decapentaplegic homolog 3 isoform 2
[Homo sapiens]
Length = 320
Score = 101 bits (252), Expect = 5e-22
Identities = 74/235 (31%), Positives = 115/235 (48%), Gaps = 21/235 (8%)
Query: 12 KSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDAT-----K 66
++PPP Y LS E SD ++++ + +L +P S A + D +
Sbjct: 73 ETPPPGY--LSEDGE-----TSDHQMNHSMDAGSPNL--SPNPMSPAHNNLDLQPVTYCE 123
Query: 67 PSHWCSVAYWEHRTRVGRLYAVYDQAVSI--FYDLPQGSGFCLGQLNLEQRSESVRRTRS 124
P+ WCS++Y+E RVG + ++++ F D FCLG L+ R+ +V TR
Sbjct: 124 PAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRR 183
Query: 125 KIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAP-GGRALVVRKVPPGYSIKVFDFERS 183
IG G+ L V+A + IFV SP + G V K+PPG ++K+F+ +
Sbjct: 184 HIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEF 243
Query: 184 GLQHAPEPDAA-DGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEILLNNP 234
A + + Y ++R+SF KGWG Y RQ +TS PCW+E+ LN P
Sbjct: 244 AALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGP 298
>gi|5174519 SMAD family member 9 isoform b [Homo sapiens]
Length = 430
Score = 99.8 bits (247), Expect = 2e-21
Identities = 78/228 (34%), Positives = 109/228 (47%), Gaps = 12/228 (5%)
Query: 16 PPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDA-TKPSHWCSVA 74
PP S L P + S T SY + + S +P + SD P +P HWCSVA
Sbjct: 184 PPCSALPPSPSHA-FSQSPCTASYPHSPGSPSEPESPYQHSD--FRPVCYEEPQHWCSVA 240
Query: 75 YWEHRTRVGRLYAVYDQAVSI--FYDLPQGSG-FCLGQLNLEQRSESVRRTRSKIGFGIL 131
Y+E RVG + ++V I F D FCLG L+ R+ ++ TR IG G+
Sbjct: 241 YYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVH 300
Query: 132 LSKEPDGVWAYNRGEHPIFVNSPTLDAPGG-RALVVRKVPPGYSIKVFDFER-SGLQHAP 189
L V+A + IFV S + G V K+P G S+KVF+ + + L
Sbjct: 301 LYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQS 360
Query: 190 EPDAADGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEILLNNP 234
+ Y+ ++R+SF KGWG Y RQ +TS PCW+EI L+ P
Sbjct: 361 VHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGP 408
>gi|223029444 mothers against decapentaplegic homolog 3 isoform 4
[Homo sapiens]
Length = 230
Score = 99.8 bits (247), Expect = 2e-21
Identities = 60/176 (34%), Positives = 91/176 (51%), Gaps = 7/176 (3%)
Query: 66 KPSHWCSVAYWEHRTRVGRLYAVYDQAVSI--FYDLPQGSGFCLGQLNLEQRSESVRRTR 123
+P+ WCS++Y+E RVG + ++++ F D FCLG L+ R+ +V TR
Sbjct: 33 EPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTR 92
Query: 124 SKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAP-GGRALVVRKVPPGYSIKVFDFER 182
IG G+ L V+A + IFV SP + G V K+PPG ++K+F+ +
Sbjct: 93 RHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQE 152
Query: 183 SGLQHAPEPDAA-DGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEILLNNP 234
A + + Y ++R+SF KGWG Y RQ +TS PCW+E+ LN P
Sbjct: 153 FAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGP 208
>gi|4885457 mothers against decapentaplegic homolog 4 [Homo sapiens]
Length = 552
Score = 99.0 bits (245), Expect = 3e-21
Identities = 70/211 (33%), Positives = 93/211 (44%), Gaps = 45/211 (21%)
Query: 67 PSHWCSVAYWEHRTRVGRLYAVYDQA----VSIFYDLPQGSGFCLGQLNLEQRSESVRRT 122
P +WCS+AY+E +VG + V V + D G FCLGQL+ R+E++ R
Sbjct: 320 PEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERA 379
Query: 123 RSKIGFGILLSKEPDG-VWAYNRGEHPIFVNSPTLDAPGGRAL--VVRKVPPGYSIKVFD 179
R IG G+ L + +G VW +H +FV S LD GRA V K+ P IKVFD
Sbjct: 380 RLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFD 439
Query: 180 FERSGLQ---------------------HAPEPDAADGPYDPNS---------------- 202
+ Q + P P + G S
Sbjct: 440 LRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLC 499
Query: 203 -VRISFAKGWGPCYSRQFITSCPCWLEILLN 232
+R+SF KGWGP Y RQ I PCW+EI L+
Sbjct: 500 ILRMSFVKGWGPDYPRQSIKETPCWIEIHLH 530
>gi|187828357 SMAD family member 9 isoform a [Homo sapiens]
Length = 467
Score = 96.7 bits (239), Expect = 2e-20
Identities = 80/242 (33%), Positives = 111/242 (45%), Gaps = 27/242 (11%)
Query: 17 PYSRLSPRDEYKPLDLSDST--LSYTETEATNSLITAPGEFSDASMSPDAT--------- 65
P+S SP + P S T L Y TEA+ T G+ DA+
Sbjct: 207 PHSPGSPSEPESPYQHSVDTPPLPYHATEASE---TQSGQPVDATADRHVVLSIPNGDFR 263
Query: 66 -----KPSHWCSVAYWEHRTRVGRLYAVYDQAVSI--FYDLPQGSG-FCLGQLNLEQRSE 117
+P HWCSVAY+E RVG + ++V I F D FCLG L+ R+
Sbjct: 264 PVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNS 323
Query: 118 SVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGG-RALVVRKVPPGYSIK 176
++ TR IG G+ L V+A + IFV S + G V K+P G S+K
Sbjct: 324 TIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLK 383
Query: 177 VFDFER-SGLQHAPEPDAADGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEILLN 232
VF+ + + L + Y+ ++R+SF KGWG Y RQ +TS PCW+EI L+
Sbjct: 384 VFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLH 443
Query: 233 NP 234
P
Sbjct: 444 GP 445
>gi|51173727 Sma- and Mad-related protein 1 [Homo sapiens]
Length = 465
Score = 95.5 bits (236), Expect = 3e-20
Identities = 75/239 (31%), Positives = 108/239 (45%), Gaps = 17/239 (7%)
Query: 5 GKPIETQKSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDA 64
G P + PPP + L P D P+ S T A P E + + A
Sbjct: 213 GSPFQMPADTPPP-AYLPPED---PMTQDGSQPMDTNMMAP----PLPSEINRGDVQAVA 264
Query: 65 -TKPSHWCSVAYWEHRTRVGRLYAVYDQAVSI--FYDLPQGSG-FCLGQLNLEQRSESVR 120
+P HWCS+ Y+E RVG + +V + F D FCLG L+ R+ ++
Sbjct: 265 YEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIE 324
Query: 121 RTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGG-RALVVRKVPPGYSIKVFD 179
TR IG G+ L V+A + IFV S + G V K+P G S+K+F+
Sbjct: 325 NTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFN 384
Query: 180 FERSGLQHAPEPDAA-DGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEILLNNP 234
+ A + + Y+ ++R+SF KGWG Y RQ +TS PCW+EI L+ P
Sbjct: 385 NQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGP 443
>gi|5174509 Sma- and Mad-related protein 1 [Homo sapiens]
Length = 465
Score = 95.5 bits (236), Expect = 3e-20
Identities = 75/239 (31%), Positives = 108/239 (45%), Gaps = 17/239 (7%)
Query: 5 GKPIETQKSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDA 64
G P + PPP + L P D P+ S T A P E + + A
Sbjct: 213 GSPFQMPADTPPP-AYLPPED---PMTQDGSQPMDTNMMAP----PLPSEINRGDVQAVA 264
Query: 65 -TKPSHWCSVAYWEHRTRVGRLYAVYDQAVSI--FYDLPQGSG-FCLGQLNLEQRSESVR 120
+P HWCS+ Y+E RVG + +V + F D FCLG L+ R+ ++
Sbjct: 265 YEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIE 324
Query: 121 RTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGG-RALVVRKVPPGYSIKVFD 179
TR IG G+ L V+A + IFV S + G V K+P G S+K+F+
Sbjct: 325 NTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFN 384
Query: 180 FERSGLQHAPEPDAA-DGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEILLNNP 234
+ A + + Y+ ++R+SF KGWG Y RQ +TS PCW+EI L+ P
Sbjct: 385 NQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGP 443
>gi|47778931 SMAD, mothers against DPP homolog 5 [Homo sapiens]
Length = 465
Score = 95.5 bits (236), Expect = 3e-20
Identities = 74/244 (30%), Positives = 111/244 (45%), Gaps = 26/244 (10%)
Query: 5 GKPIETQKSPPPPYSRLSPRDEY-----KPLDLSDSTLSYTETEATNSLITAPGEFSDAS 59
G P + PPP + + P D+ +P+D S+ N + S
Sbjct: 212 GSPFQLPADTPPP-AYMPPDDQMGQDNSQPMDTSN-----------NMIPQIMPSISSRD 259
Query: 60 MSPDA-TKPSHWCSVAYWEHRTRVGRLYAVYDQAVSI--FYDLPQG-SGFCLGQLNLEQR 115
+ P A +P HWCS+ Y+E RVG + +V + F D S FCLG L+ R
Sbjct: 260 VQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNR 319
Query: 116 SESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGG-RALVVRKVPPGYS 174
+ ++ TR IG G+ L V+A + IFV S + G V K+P S
Sbjct: 320 NSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCS 379
Query: 175 IKVFDFERSGLQHAPEPDAA-DGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEIL 230
+K+F+ + A + + Y+ ++R+SF KGWG Y RQ +TS PCW+EI
Sbjct: 380 LKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIH 439
Query: 231 LNNP 234
L+ P
Sbjct: 440 LHGP 443
>gi|47778929 SMAD, mothers against DPP homolog 5 [Homo sapiens]
Length = 465
Score = 95.5 bits (236), Expect = 3e-20
Identities = 74/244 (30%), Positives = 111/244 (45%), Gaps = 26/244 (10%)
Query: 5 GKPIETQKSPPPPYSRLSPRDEY-----KPLDLSDSTLSYTETEATNSLITAPGEFSDAS 59
G P + PPP + + P D+ +P+D S+ N + S
Sbjct: 212 GSPFQLPADTPPP-AYMPPDDQMGQDNSQPMDTSN-----------NMIPQIMPSISSRD 259
Query: 60 MSPDA-TKPSHWCSVAYWEHRTRVGRLYAVYDQAVSI--FYDLPQG-SGFCLGQLNLEQR 115
+ P A +P HWCS+ Y+E RVG + +V + F D S FCLG L+ R
Sbjct: 260 VQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNR 319
Query: 116 SESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGG-RALVVRKVPPGYS 174
+ ++ TR IG G+ L V+A + IFV S + G V K+P S
Sbjct: 320 NSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCS 379
Query: 175 IKVFDFERSGLQHAPEPDAA-DGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEIL 230
+K+F+ + A + + Y+ ++R+SF KGWG Y RQ +TS PCW+EI
Sbjct: 380 LKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIH 439
Query: 231 LNNP 234
L+ P
Sbjct: 440 LHGP 443
>gi|47778925 SMAD, mothers against DPP homolog 5 [Homo sapiens]
Length = 465
Score = 95.5 bits (236), Expect = 3e-20
Identities = 74/244 (30%), Positives = 111/244 (45%), Gaps = 26/244 (10%)
Query: 5 GKPIETQKSPPPPYSRLSPRDEY-----KPLDLSDSTLSYTETEATNSLITAPGEFSDAS 59
G P + PPP + + P D+ +P+D S+ N + S
Sbjct: 212 GSPFQLPADTPPP-AYMPPDDQMGQDNSQPMDTSN-----------NMIPQIMPSISSRD 259
Query: 60 MSPDA-TKPSHWCSVAYWEHRTRVGRLYAVYDQAVSI--FYDLPQG-SGFCLGQLNLEQR 115
+ P A +P HWCS+ Y+E RVG + +V + F D S FCLG L+ R
Sbjct: 260 VQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNR 319
Query: 116 SESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGG-RALVVRKVPPGYS 174
+ ++ TR IG G+ L V+A + IFV S + G V K+P S
Sbjct: 320 NSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCS 379
Query: 175 IKVFDFERSGLQHAPEPDAA-DGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEIL 230
+K+F+ + A + + Y+ ++R+SF KGWG Y RQ +TS PCW+EI
Sbjct: 380 LKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIH 439
Query: 231 LNNP 234
L+ P
Sbjct: 440 LHGP 443
>gi|124256489 crooked neck-like 1 protein [Homo sapiens]
Length = 848
Score = 31.6 bits (70), Expect = 0.62
Identities = 28/123 (22%), Positives = 52/123 (42%), Gaps = 22/123 (17%)
Query: 3 RMGKPIETQKSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSP 62
R K E + PPPP +++ +E L+D L +T F D ++
Sbjct: 196 REAKERELELLPPPPQQKITDEEE-----LNDYKLRKRKT------------FED-NIRK 237
Query: 63 DATKPSHWCSVAYWEHRTR-VGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRR 121
+ T S+W A WE + + R ++Y++A+ + Y + L +E ++ V
Sbjct: 238 NRTVISNWIKYAQWEESLKEIQRARSIYERALDVDY---RNITLWLKYAEMEMKNRQVNH 294
Query: 122 TRS 124
R+
Sbjct: 295 ARN 297
>gi|22538426 TRAF3 interacting protein 2 isoform 1 [Homo sapiens]
Length = 574
Score = 30.0 bits (66), Expect = 1.8
Identities = 21/59 (35%), Positives = 27/59 (45%), Gaps = 8/59 (13%)
Query: 7 PIETQKSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAP-------GEFSDA 58
P+E +S P P L P EY P + S+ A NSL +AP G+FS A
Sbjct: 15 PVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSL-SAPTMLHNSSGDFSQA 72
>gi|22538428 TRAF3 interacting protein 2 isoform 2 [Homo sapiens]
Length = 565
Score = 30.0 bits (66), Expect = 1.8
Identities = 21/59 (35%), Positives = 27/59 (45%), Gaps = 8/59 (13%)
Query: 7 PIETQKSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAP-------GEFSDA 58
P+E +S P P L P EY P + S+ A NSL +AP G+FS A
Sbjct: 6 PVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSL-SAPTMLHNSSGDFSQA 63
>gi|187761317 tet oncogene family member 2 isoform a [Homo sapiens]
Length = 2002
Score = 29.6 bits (65), Expect = 2.3
Identities = 15/56 (26%), Positives = 26/56 (46%)
Query: 1 MSRMGKPIETQKSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFS 56
M + +P QK PP P + P+ + ++S SY+ + +TN + P S
Sbjct: 1522 MQQSQQPQPLQKQPPQPQQQQRPQQQQPHHPQTESVNSYSASGSTNPYMRRPNPVS 1577
>gi|239757409 PREDICTED: similar to zinc finger protein 208 [Homo
sapiens]
Length = 1059
Score = 29.6 bits (65), Expect = 2.3
Identities = 18/63 (28%), Positives = 29/63 (46%), Gaps = 3/63 (4%)
Query: 5 GKPIETQKSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDA 64
G P + PPPP P+ +KP S+ S + + +++S + S +S S A
Sbjct: 63 GPPPQPPPQPPPPQYDYPPQSTFKPKAEVPSSSSSSSSSSSSS---SSSSSSSSSSSSQA 119
Query: 65 TKP 67
KP
Sbjct: 120 KKP 122
>gi|239746371 PREDICTED: similar to zinc finger protein 208 [Homo
sapiens]
Length = 1059
Score = 29.6 bits (65), Expect = 2.3
Identities = 18/63 (28%), Positives = 29/63 (46%), Gaps = 3/63 (4%)
Query: 5 GKPIETQKSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDA 64
G P + PPPP P+ +KP S+ S + + +++S + S +S S A
Sbjct: 63 GPPPQPPPQPPPPQYDYPPQSTFKPKAEVPSSSSSSSSSSSSS---SSSSSSSSSSSSQA 119
Query: 65 TKP 67
KP
Sbjct: 120 KKP 122
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 29.6 bits (65), Expect = 2.3
Identities = 20/59 (33%), Positives = 27/59 (45%), Gaps = 1/59 (1%)
Query: 7 PIETQKSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDAT 65
P E+ SPPP SRLSP E P L + S ++ P E S S P+++
Sbjct: 453 PEESPTSPPPEASRLSPPPEELPASPLPEAL-HLSRPLEESPLSPPPEESPLSPPPESS 510
Score = 29.6 bits (65), Expect = 2.3
Identities = 22/61 (36%), Positives = 27/61 (44%), Gaps = 1/61 (1%)
Query: 8 IETQKSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKP 67
+ET SPPP S LSP E PL L T S ++ P E S S P+ +
Sbjct: 532 LETPLSPPPEASPLSPPFEESPLSPPPEELP-TSPPPEASRLSPPPEESPMSPPPEESPM 590
Query: 68 S 68
S
Sbjct: 591 S 591
Score = 28.9 bits (63), Expect = 4.0
Identities = 25/71 (35%), Positives = 34/71 (47%), Gaps = 10/71 (14%)
Query: 7 PIETQKSPPPPYSRLSPRDEYKPLD--LSDSTLSYTETEAT-------NSLITAPGEFSD 57
P E SPPP SRLSP E P+ +S +S EA+ S ++ P E S
Sbjct: 558 PEELPTSPPPEASRLSPPPEESPMSPPPEESPMS-PPPEASRLFPPFEESPLSPPPEESP 616
Query: 58 ASMSPDATKPS 68
S P+A++ S
Sbjct: 617 LSPPPEASRLS 627
Score = 28.1 bits (61), Expect = 6.8
Identities = 13/24 (54%), Positives = 15/24 (62%)
Query: 7 PIETQKSPPPPYSRLSPRDEYKPL 30
P E+ SPPP SRLSP E P+
Sbjct: 612 PEESPLSPPPEASRLSPPPEDSPM 635
Score = 27.7 bits (60), Expect = 8.9
Identities = 18/51 (35%), Positives = 24/51 (47%), Gaps = 2/51 (3%)
Query: 4 MGKPIETQK-SPPPPYSRLSPRDEYKPLD-LSDSTLSYTETEATNSLITAP 52
+ +P+E SPPP S LSP E P L +S LS E + + P
Sbjct: 485 LSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETP 535
Score = 27.7 bits (60), Expect = 8.9
Identities = 20/62 (32%), Positives = 27/62 (43%), Gaps = 10/62 (16%)
Query: 7 PIETQKSPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATK 66
P E+ SPPP SRLSP +S S ++ P E S S P+A++
Sbjct: 639 PEESPMSPPPEVSRLSPL----------PVVSRLSPPPEESPLSPPPEESPTSPPPEASR 688
Query: 67 PS 68
S
Sbjct: 689 LS 690
Score = 27.7 bits (60), Expect = 8.9
Identities = 13/23 (56%), Positives = 14/23 (60%)
Query: 7 PIETQKSPPPPYSRLSPRDEYKP 29
P E+ SPPP SRLSP E P
Sbjct: 675 PEESPTSPPPEASRLSPPPEDSP 697
>gi|37059810 ring finger protein 212 isoform b [Homo sapiens]
Length = 232
Score = 29.3 bits (64), Expect = 3.1
Identities = 19/64 (29%), Positives = 29/64 (45%)
Query: 16 PPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAY 75
PP+S R E +DLS S + +E A + I+ D M+P A + H+
Sbjct: 147 PPHSSAPDRLESMEVDLSPSPIRKSEIAAGPARISMISPPQDGRMAPCARRVCHFQRFTM 206
Query: 76 WEHR 79
+ HR
Sbjct: 207 FLHR 210
>gi|10047138 NADH:ubiquinone oxidoreductase MLRQ subunit homolog
[Homo sapiens]
Length = 87
Score = 29.3 bits (64), Expect = 3.1
Identities = 12/23 (52%), Positives = 18/23 (78%)
Query: 11 QKSPPPPYSRLSPRDEYKPLDLS 33
+K+ P P++RLSP D+YK L +S
Sbjct: 52 RKNNPEPWNRLSPNDQYKFLAVS 74
>gi|134254450 patched isoform S [Homo sapiens]
Length = 1296
Score = 28.5 bits (62), Expect = 5.2
Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 5/54 (9%)
Query: 18 YSRLSPRDEY--KPLDLSDSTLSYTETEATNSLITAPGEFSDAS---MSPDATK 66
Y+ PR E +P+ ++ TLS E+T+S +FSD+S + P TK
Sbjct: 525 YTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTK 578
>gi|134254435 patched isoform S [Homo sapiens]
Length = 1296
Score = 28.5 bits (62), Expect = 5.2
Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 5/54 (9%)
Query: 18 YSRLSPRDEY--KPLDLSDSTLSYTETEATNSLITAPGEFSDAS---MSPDATK 66
Y+ PR E +P+ ++ TLS E+T+S +FSD+S + P TK
Sbjct: 525 YTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTK 578
>gi|134254468 patched isoform S [Homo sapiens]
Length = 1296
Score = 28.5 bits (62), Expect = 5.2
Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 5/54 (9%)
Query: 18 YSRLSPRDEY--KPLDLSDSTLSYTETEATNSLITAPGEFSDAS---MSPDATK 66
Y+ PR E +P+ ++ TLS E+T+S +FSD+S + P TK
Sbjct: 525 YTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTK 578
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,839,247
Number of Sequences: 37866
Number of extensions: 533648
Number of successful extensions: 1415
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1320
Number of HSP's gapped (non-prelim): 62
length of query: 235
length of database: 18,247,518
effective HSP length: 99
effective length of query: 136
effective length of database: 14,498,784
effective search space: 1971834624
effective search space used: 1971834624
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.