Search of human proteins with 216547801

Search of human proteins with 216547801

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens]
         (700 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens]       1405   0.0  
gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens]       1400   0.0  
gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens]       1357   0.0  
gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens]        1355   0.0  
gi|216547779 SH2 domain containing 3C isoform c [Homo sapiens]       1011   0.0  
gi|216547769 SH2 domain containing 3C isoform c [Homo sapiens]       1011   0.0  
gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens]     548   e-156
gi|208609985 SH2 domain containing 3A [Homo sapiens]                  315   7e-86
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]      74   6e-13
gi|194239668 SHC (Src homology 2 domain containing) transforming...    57   6e-08
gi|194239664 SHC (Src homology 2 domain containing) transforming...    57   6e-08
gi|194239662 SHC (Src homology 2 domain containing) transforming...    57   6e-08
gi|32261324 SHC (Src homology 2 domain containing) transforming ...    57   6e-08
gi|222446609 rai-like protein [Homo sapiens]                           56   1e-07
gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-lik...    55   2e-07
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]          55   2e-07
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]            55   2e-07
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ...    55   2e-07
gi|169790811 SHC (Src homology 2 domain containing) transforming...    55   2e-07
gi|224586793 src homology 2 domain-containing transforming prote...    53   1e-06
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]              50   5e-06
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]                50   5e-06
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]              50   5e-06
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]              50   5e-06
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]              50   5e-06
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...    50   9e-06
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...    50   9e-06
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]             50   9e-06
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom...    49   1e-05
gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ...    48   3e-05

>gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens]
          Length = 700

 Score = 1405 bits (3637), Expect = 0.0
 Identities = 700/700 (100%), Positives = 700/700 (100%)

Query: 1   MTERCSLWSALSAAACCFYRGSFVQFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAW 60
           MTERCSLWSALSAAACCFYRGSFVQFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAW
Sbjct: 1   MTERCSLWSALSAAACCFYRGSFVQFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAW 60

Query: 61  YHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTH 120
           YHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTH
Sbjct: 61  YHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTH 120

Query: 121 IQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSK 180
           IQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSK
Sbjct: 121 IQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSK 180

Query: 181 PASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQI 240
           PASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQI
Sbjct: 181 PASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQI 240

Query: 241 PDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTH 300
           PDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTH
Sbjct: 241 PDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTH 300

Query: 301 GESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARS 360
           GESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARS
Sbjct: 301 GESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARS 360

Query: 361 YGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKE 420
           YGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKE
Sbjct: 361 YGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKE 420

Query: 421 LLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERF 480
           LLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERF
Sbjct: 421 LLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERF 480

Query: 481 HTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRL 540
           HTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRL
Sbjct: 481 HTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRL 540

Query: 541 EQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPP 600
           EQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPP
Sbjct: 541 EQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPP 600

Query: 601 EGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQM 660
           EGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQM
Sbjct: 601 EGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQM 660

Query: 661 RLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL 700
           RLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL
Sbjct: 661 RLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL 700


>gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens]
          Length = 702

 Score = 1400 bits (3624), Expect = 0.0
 Identities = 700/702 (99%), Positives = 700/702 (99%), Gaps = 2/702 (0%)

Query: 1   MTERCSLWSALSAAACCFYRGSFVQ--FSKEKYILDSSPEKLHKELEEELKLSSTDLRSH 58
           MTERCSLWSALSAAACCFYRGSFVQ  FSKEKYILDSSPEKLHKELEEELKLSSTDLRSH
Sbjct: 1   MTERCSLWSALSAAACCFYRGSFVQVQFSKEKYILDSSPEKLHKELEEELKLSSTDLRSH 60

Query: 59  AWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESY 118
           AWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESY
Sbjct: 61  AWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESY 120

Query: 119 THIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGS 178
           THIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGS
Sbjct: 121 THIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGS 180

Query: 179 SKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMD 238
           SKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMD
Sbjct: 181 SKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMD 240

Query: 239 QIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPK 298
           QIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPK
Sbjct: 241 QIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPK 300

Query: 299 THGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQA 358
           THGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQA
Sbjct: 301 THGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQA 360

Query: 359 RSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKV 418
           RSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKV
Sbjct: 361 RSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKV 420

Query: 419 KELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLE 478
           KELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLE
Sbjct: 421 KELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLE 480

Query: 479 RFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQIS 538
           RFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQIS
Sbjct: 481 RFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQIS 540

Query: 539 RLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSA 598
           RLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSA
Sbjct: 541 RLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSA 600

Query: 599 PPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEF 658
           PPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEF
Sbjct: 601 PPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEF 660

Query: 659 QMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL 700
           QMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL
Sbjct: 661 QMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL 702


>gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens]
          Length = 703

 Score = 1357 bits (3511), Expect = 0.0
 Identities = 680/697 (97%), Positives = 683/697 (97%)

Query: 4   RCSLWSALSAAACCFYRGSFVQFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHG 63
           RC    +  AA        +V+FSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHG
Sbjct: 7   RCPALGSRGAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHG 66

Query: 64  RIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQY 123
           RIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQY
Sbjct: 67  RIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQY 126

Query: 124 LFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPAS 183
           LFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPAS
Sbjct: 127 LFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPAS 186

Query: 184 PVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDL 243
           PVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDL
Sbjct: 187 PVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDL 246

Query: 244 HSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGES 303
           HSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGES
Sbjct: 247 HSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGES 306

Query: 304 DKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGE 363
           DKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGE
Sbjct: 307 DKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGE 366

Query: 364 RLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLA 423
           RLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLA
Sbjct: 367 RLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLA 426

Query: 424 EVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTM 483
           EVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTM
Sbjct: 427 EVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTM 486

Query: 484 SIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQT 543
           SIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQT
Sbjct: 487 SIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQT 546

Query: 544 WVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGP 603
           WVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGP
Sbjct: 547 WVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGP 606

Query: 604 EPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLL 663
           EPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLL
Sbjct: 607 EPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLL 666

Query: 664 WGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL 700
           WGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL
Sbjct: 667 WGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL 703


>gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens]
          Length = 860

 Score = 1355 bits (3508), Expect = 0.0
 Identities = 676/678 (99%), Positives = 678/678 (100%)

Query: 23  FVQFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLI 82
           +V+FSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLI
Sbjct: 183 YVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLI 242

Query: 83  RDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVG 142
           RDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVG
Sbjct: 243 RDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVG 302

Query: 143 SRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTM 202
           SRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTM
Sbjct: 303 SRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTM 362

Query: 203 TDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTV 262
           TDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTV
Sbjct: 363 TDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTV 422

Query: 263 TRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSP 322
           TRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSP
Sbjct: 423 TRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSP 482

Query: 323 SLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTF 382
           SLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTF
Sbjct: 483 SLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTF 542

Query: 383 TVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVA 442
           TVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVA
Sbjct: 543 TVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVA 602

Query: 443 RILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERA 502
           RILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERA
Sbjct: 603 RILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERA 662

Query: 503 ALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKL 562
           ALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKL
Sbjct: 663 ALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKL 722

Query: 563 KPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEA 622
           KPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEA
Sbjct: 723 KPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEA 782

Query: 623 ARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDK 682
           ARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDK
Sbjct: 783 ARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDK 842

Query: 683 VLTALSHKLEPAVRSSEL 700
           VLTALSHKLEPAVRSSEL
Sbjct: 843 VLTALSHKLEPAVRSSEL 860


>gi|216547779 SH2 domain containing 3C isoform c [Homo sapiens]
          Length = 506

 Score = 1011 bits (2613), Expect = 0.0
 Identities = 506/506 (100%), Positives = 506/506 (100%)

Query: 195 MKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESP 254
           MKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESP
Sbjct: 1   MKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESP 60

Query: 255 SSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHT 314
           SSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHT
Sbjct: 61  SSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHT 120

Query: 315 LGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAP 374
           LGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAP
Sbjct: 121 LGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAP 180

Query: 375 EGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHV 434
           EGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHV
Sbjct: 181 EGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHV 240

Query: 435 TKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGC 494
           TKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGC
Sbjct: 241 TKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGC 300

Query: 495 TGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEG 554
           TGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEG
Sbjct: 301 TGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEG 360

Query: 555 AILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVE 614
           AILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVE
Sbjct: 361 AILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVE 420

Query: 615 VVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQA 674
           VVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQA
Sbjct: 421 VVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQA 480

Query: 675 RRYEKFDKVLTALSHKLEPAVRSSEL 700
           RRYEKFDKVLTALSHKLEPAVRSSEL
Sbjct: 481 RRYEKFDKVLTALSHKLEPAVRSSEL 506


>gi|216547769 SH2 domain containing 3C isoform c [Homo sapiens]
          Length = 506

 Score = 1011 bits (2613), Expect = 0.0
 Identities = 506/506 (100%), Positives = 506/506 (100%)

Query: 195 MKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESP 254
           MKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESP
Sbjct: 1   MKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESP 60

Query: 255 SSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHT 314
           SSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHT
Sbjct: 61  SSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHT 120

Query: 315 LGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAP 374
           LGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAP
Sbjct: 121 LGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAP 180

Query: 375 EGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHV 434
           EGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHV
Sbjct: 181 EGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHV 240

Query: 435 TKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGC 494
           TKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGC
Sbjct: 241 TKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGC 300

Query: 495 TGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEG 554
           TGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEG
Sbjct: 301 TGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEG 360

Query: 555 AILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVE 614
           AILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVE
Sbjct: 361 AILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVE 420

Query: 615 VVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQA 674
           VVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQA
Sbjct: 421 VVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQA 480

Query: 675 RRYEKFDKVLTALSHKLEPAVRSSEL 700
           RRYEKFDKVLTALSHKLEPAVRSSEL
Sbjct: 481 RRYEKFDKVLTALSHKLEPAVRSSEL 506


>gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens]
          Length = 825

 Score =  548 bits (1413), Expect = e-156
 Identities = 321/721 (44%), Positives = 444/721 (61%), Gaps = 55/721 (7%)

Query: 23  FVQFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLI 82
           +V+FSKE++I+D +PEKL KELEEEL LSS DLRSHAWYHGRIPR+VSE LVQR+GDFL+
Sbjct: 117 YVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLV 176

Query: 83  RDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVG 142
           RDSL+S G++VLTC+W+N A HFKIN+ V++  E+Y+ +QY FE ESFD +P LVR +VG
Sbjct: 177 RDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVG 236

Query: 143 SRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTM 202
           +R+ +S+QSGAII+ P+NRT PLR LE  YG   G ++  S ++   P  +  KR S+TM
Sbjct: 237 NRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGS-LTKGRPDVA--KRLSLTM 293

Query: 203 TDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTV 262
             G+ A    R    P    L R ++   S    +D + D  +      +S S   Y  +
Sbjct: 294 -GGVQA----REQNLPRGNLL-RNKEKSGSQPACLDHMQDRRALSLKAHQSES---YLPI 344

Query: 263 -TRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGP--HTSPSHTLGKAS 319
             ++    +    +  P SPV R  SEP L P    +   ++  G     S S    K  
Sbjct: 345 GCKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPP 404

Query: 320 PSPS----LSSYSDPDS-----GHYCQLQPPV-----RGSREWAATETSSQQA------- 358
           P P     L   S P +      +YC+L P       RG++  +  + S  +        
Sbjct: 405 PKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNE 464

Query: 359 ----RSYG-----------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSLL 402
               R+ G           ER  E +     +G W K  F  P++E  SSF P  F+S  
Sbjct: 465 APGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKF 524

Query: 403 IPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGME 462
           +P +N+PLE  +L++ KEL    D + +A+HV  +DC VARILGV++EM+  MGV  G+E
Sbjct: 525 LPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLE 584

Query: 463 LLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNM 522
           L+TLPHG QLRLD++ER +TM+I +AVDILGCTG+ E+RAA L K IQ+A EL+ +MG++
Sbjct: 585 LITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDL 644

Query: 523 FSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGP--PLSN 580
           +SF+A+M AL+M QI+RLE+TW  LR ++T+ AILYEK+LKPF K L+EG+E    P +N
Sbjct: 645 YSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNN 704

Query: 581 TTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVK 640
            + P ++PL+TL+E  +   EG + W   +   E++L HL  AR +A     Y  NAE  
Sbjct: 705 VSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERI 764

Query: 641 LQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLE-PAVRSSE 699
           L GFQ   E+ E+  TEFQMRLLWGS+GA  +Q  RYEKF+++LTALS KLE P V+ +E
Sbjct: 765 LAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAE 824

Query: 700 L 700
           L
Sbjct: 825 L 825


>gi|208609985 SH2 domain containing 3A [Homo sapiens]
          Length = 576

 Score =  315 bits (808), Expect = 7e-86
 Identities = 219/646 (33%), Positives = 320/646 (49%), Gaps = 86/646 (13%)

Query: 54  DLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVK 113
           DL    WYHG + R+ +E L+Q+NGDFL+R S +  G+ V++CRWR  ALHF++ +V ++
Sbjct: 9   DLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALR 68

Query: 114 AGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYG 173
                    +  E E F  +PALV  ++  R+ +S+ +GA++                  
Sbjct: 69  PRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVV------------------ 110

Query: 174 LGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSC 233
                   + PV+  GP      RRS +        + T  DG       P   + +R+ 
Sbjct: 111 --------SRPVTWQGPL-----RRSFS--------EDTLMDG-------PARIEPLRAR 142

Query: 234 ALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCP 293
             S  Q  DL                + + R    PA   A+ +P S + R SS+P L  
Sbjct: 143 KWSNSQPADL----------------AHMGRSREDPAGMEASTMPISALPRTSSDPVLLK 186

Query: 294 GSAPKTHGESDKGPHTSPSHTLGKASPSPSLS-SYSDPDSGH----YCQLQPPVRGSREW 348
             AP   G        S      KA   P  + S+  PD+      YC+L P V   +  
Sbjct: 187 APAPL--GTVADSLRASDGQLQAKAPTKPPRTPSFELPDASERPPTYCELVPRVPSVQGT 244

Query: 349 AATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNR 408
           + +++  +    + E  ++  E         + FT P  E+  SF P    S L+   NR
Sbjct: 245 SPSQSCPEPEAPWWEAEEDEEEEN-------RCFTRPQAEI--SFCPHDAPSCLLGPQNR 295

Query: 409 PLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPH 468
           PLE  +L  ++ L  E    + A H+  VDC    +LGVT++ +  MGV  G+ELLTLPH
Sbjct: 296 PLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQATGLLGVTRDQRGNMGVSSGLELLTLPH 355

Query: 469 GRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELR-GTMGNMFSFAA 527
           G  LRL+LLER  T+++  A+ +LGC+G  EERAA L   ++LA  LR G  G++   AA
Sbjct: 356 GHHLRLELLERHQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDLPGLAA 415

Query: 528 VMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVL 587
           VMGAL M Q+SRLE TW  LR+ HTE A+ +E++LKP +++L+EG           PHV 
Sbjct: 416 VMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHVA 475

Query: 588 PLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQAR 647
           P++ LL       EG E  G  +   E +L  L  AR +      +   A  +L+GF+  
Sbjct: 476 PMVRLL-------EGEEVAGPLDESCERLLRTLHGARHMVRDAPKFRKVAAQRLRGFRPN 528

Query: 648 PELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEP 693
           PEL E  +T F  RLLWGS+GA + +A R+EKF +VL  LS +LEP
Sbjct: 529 PELREALTTGFVRRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEP 574


>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
          Length = 822

 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 36/116 (31%), Positives = 62/116 (53%), Gaps = 9/116 (7%)

Query: 44  LEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQAL 103
           L + + +S   L    WYHG IPR  ++ L+++ GDFL+R+S    G+YVL+     Q  
Sbjct: 444 LSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRR 503

Query: 104 HFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPV 159
           HF I          Y    Y FE   F ++P L+ +H  +++ ++++SG ++  P+
Sbjct: 504 HFII---------QYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPI 550


>gi|194239668 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 4 [Homo sapiens]
          Length = 473

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 3/85 (3%)

Query: 55  LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKI---NKVV 111
           LR   W+HG++ R  +E L+Q NGDFL+R+S T+ G YVLT     Q  H  +     VV
Sbjct: 373 LRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVV 432

Query: 112 VKAGESYTHIQYLFEQESFDHVPAL 136
                 +  + +L      +H+P +
Sbjct: 433 RTKDHRFESVSHLISYHMDNHLPII 457


>gi|194239664 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 3 [Homo sapiens]
          Length = 584

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 3/85 (3%)

Query: 55  LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKI---NKVV 111
           LR   W+HG++ R  +E L+Q NGDFL+R+S T+ G YVLT     Q  H  +     VV
Sbjct: 484 LRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVV 543

Query: 112 VKAGESYTHIQYLFEQESFDHVPAL 136
                 +  + +L      +H+P +
Sbjct: 544 RTKDHRFESVSHLISYHMDNHLPII 568


>gi|194239662 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 1 [Homo sapiens]
          Length = 583

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 3/85 (3%)

Query: 55  LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKI---NKVV 111
           LR   W+HG++ R  +E L+Q NGDFL+R+S T+ G YVLT     Q  H  +     VV
Sbjct: 483 LRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVV 542

Query: 112 VKAGESYTHIQYLFEQESFDHVPAL 136
                 +  + +L      +H+P +
Sbjct: 543 RTKDHRFESVSHLISYHMDNHLPII 567


>gi|32261324 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 2 [Homo sapiens]
          Length = 474

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 3/85 (3%)

Query: 55  LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKI---NKVV 111
           LR   W+HG++ R  +E L+Q NGDFL+R+S T+ G YVLT     Q  H  +     VV
Sbjct: 374 LRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVV 433

Query: 112 VKAGESYTHIQYLFEQESFDHVPAL 136
                 +  + +L      +H+P +
Sbjct: 434 RTKDHRFESVSHLISYHMDNHLPII 458


>gi|222446609 rai-like protein [Homo sapiens]
          Length = 630

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 38/108 (35%), Positives = 58/108 (53%), Gaps = 10/108 (9%)

Query: 55  LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKA 114
           L S   YHG++ R+ +E+L+ ++GDFL+R+S TS G YVL+     QA H  +   V   
Sbjct: 521 LWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLL---VDPE 577

Query: 115 GESYTHIQYLFEQESFDHVPALVRYHV-GSRKAVSEQSGAIIYCPVNR 161
           G+  T      +   FD+V  L+RYH+  S   +S  S   +  PV +
Sbjct: 578 GKVRT------KDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619


>gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-like
           [Homo sapiens]
          Length = 303

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 30/84 (35%), Positives = 49/84 (58%), Gaps = 10/84 (11%)

Query: 59  AWYHGRIPREVSETLVQ--RNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGE 116
           AWY G + R+ ++T +Q  R+G FL+RDS T  GDYVL+    ++  H+ IN        
Sbjct: 13  AWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIIN-------- 64

Query: 117 SYTHIQYLFEQESFDHVPALVRYH 140
           S  + ++    + FDH+PAL+ ++
Sbjct: 65  SLPNRRFKIGDQEFDHLPALLEFY 88


>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
          Length = 764

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 35/103 (33%), Positives = 58/103 (56%), Gaps = 12/103 (11%)

Query: 55  LRSHAWYHGRIPR-EVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVK 113
           L    WYHG IPR EV+E LV  +GDFL+R+S     +YVL+  W     HF I      
Sbjct: 397 LHEQLWYHGAIPRAEVAELLV-HSGDFLVRES-QGKQEYVLSVLWDGLPRHFII------ 448

Query: 114 AGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIY 156
             +S  ++ Y  E E F  +P L+ + + +++ ++++SG +++
Sbjct: 449 --QSLDNL-YRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH 488


>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
          Length = 822

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 35/103 (33%), Positives = 58/103 (56%), Gaps = 12/103 (11%)

Query: 55  LRSHAWYHGRIPR-EVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVK 113
           L    WYHG IPR EV+E LV  +GDFL+R+S     +YVL+  W     HF I      
Sbjct: 455 LHEQLWYHGAIPRAEVAELLV-HSGDFLVRES-QGKQEYVLSVLWDGLPRHFII------ 506

Query: 114 AGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIY 156
             +S  ++ Y  E E F  +P L+ + + +++ ++++SG +++
Sbjct: 507 --QSLDNL-YRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH 546


>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
           sapiens]
          Length = 475

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 24/50 (48%), Positives = 33/50 (66%)

Query: 55  LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALH 104
           LR   WYHGR+ R  +E +++ +GDFL+RDS+T+ G YVLT     Q  H
Sbjct: 375 LRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKH 424


>gi|169790811 SHC (Src homology 2 domain containing) transforming
           protein 2 [Homo sapiens]
          Length = 582

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 24/50 (48%), Positives = 33/50 (66%)

Query: 55  LRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALH 104
           LR   WYHGR+ R  +E +++ +GDFL+RDS+T+ G YVLT     Q  H
Sbjct: 482 LRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKH 531


>gi|224586793 src homology 2 domain-containing transforming protein
           C3 [Homo sapiens]
          Length = 594

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 35/109 (32%), Positives = 55/109 (50%), Gaps = 10/109 (9%)

Query: 54  DLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVK 113
           +L++  WY G + R+ +E L++++GDFL+R S T+ G +VLT     QA H  +   V  
Sbjct: 493 ELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLL---VDP 549

Query: 114 AGESYTHIQYLFEQESFDHVPALVRYHV-GSRKAVSEQSGAIIYCPVNR 161
            G   T      +   FD +  L+ +H+  S   VS  S   +  PV R
Sbjct: 550 EGTIRT------KDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVER 592


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 27/82 (32%), Positives = 43/82 (52%), Gaps = 7/82 (8%)

Query: 55  LRSHAWYHGRIPREVSETLVQR--NGDFLIRDSLTSLGDYVLTCRWRNQALHFKIN---- 108
           L  H+WYHG + R  +E L+    NG FL+R+S +S G   ++ R+  +  H++IN    
Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 212

Query: 109 -KVVVKAGESYTHIQYLFEQES 129
            KV V A   ++ +  L    S
Sbjct: 213 GKVYVTAESRFSTLAELVHHHS 234


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 27/82 (32%), Positives = 43/82 (52%), Gaps = 7/82 (8%)

Query: 55  LRSHAWYHGRIPREVSETLVQR--NGDFLIRDSLTSLGDYVLTCRWRNQALHFKIN---- 108
           L  H+WYHG + R  +E L+    NG FL+R+S +S G   ++ R+  +  H++IN    
Sbjct: 168 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 227

Query: 109 -KVVVKAGESYTHIQYLFEQES 129
            KV V A   ++ +  L    S
Sbjct: 228 GKVYVTAESRFSTLAELVHHHS 249


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 27/82 (32%), Positives = 43/82 (52%), Gaps = 7/82 (8%)

Query: 55  LRSHAWYHGRIPREVSETLVQR--NGDFLIRDSLTSLGDYVLTCRWRNQALHFKIN---- 108
           L  H+WYHG + R  +E L+    NG FL+R+S +S G   ++ R+  +  H++IN    
Sbjct: 147 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 206

Query: 109 -KVVVKAGESYTHIQYLFEQES 129
            KV V A   ++ +  L    S
Sbjct: 207 GKVYVTAESRFSTLAELVHHHS 228


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 27/82 (32%), Positives = 43/82 (52%), Gaps = 7/82 (8%)

Query: 55  LRSHAWYHGRIPREVSETLVQR--NGDFLIRDSLTSLGDYVLTCRWRNQALHFKIN---- 108
           L  H+WYHG + R  +E L+    NG FL+R+S +S G   ++ R+  +  H++IN    
Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 212

Query: 109 -KVVVKAGESYTHIQYLFEQES 129
            KV V A   ++ +  L    S
Sbjct: 213 GKVYVTAESRFSTLAELVHHHS 234


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 27/82 (32%), Positives = 43/82 (52%), Gaps = 7/82 (8%)

Query: 55  LRSHAWYHGRIPREVSETLVQR--NGDFLIRDSLTSLGDYVLTCRWRNQALHFKIN---- 108
           L  H+WYHG + R  +E L+    NG FL+R+S +S G   ++ R+  +  H++IN    
Sbjct: 132 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 191

Query: 109 -KVVVKAGESYTHIQYLFEQES 129
            KV V A   ++ +  L    S
Sbjct: 192 GKVYVTAESRFSTLAELVHHHS 213


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 27/88 (30%), Positives = 46/88 (52%), Gaps = 9/88 (10%)

Query: 55  LRSHAWYHGRIPREVSETLVQR--NGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVV 112
           L  H+WYHG + R  +E L+    NG FL+R+S +S G   ++ R+  +  H++IN    
Sbjct: 122 LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRIN--TA 179

Query: 113 KAGESYTHIQYLFEQESFDHVPALVRYH 140
             G+      Y+  +  F+ +  LV +H
Sbjct: 180 SDGK-----LYVSSESRFNTLAELVHHH 202


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 27/88 (30%), Positives = 46/88 (52%), Gaps = 9/88 (10%)

Query: 55  LRSHAWYHGRIPREVSETLVQR--NGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVV 112
           L  H+WYHG + R  +E L+    NG FL+R+S +S G   ++ R+  +  H++IN    
Sbjct: 141 LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRIN--TA 198

Query: 113 KAGESYTHIQYLFEQESFDHVPALVRYH 140
             G+      Y+  +  F+ +  LV +H
Sbjct: 199 SDGK-----LYVSSESRFNTLAELVHHH 221


>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
          Length = 2817

 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 54/194 (27%), Positives = 79/194 (40%), Gaps = 30/194 (15%)

Query: 178  SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSM 237
            SS PAS  +P+    S     SVT+   L +  +        STS P P           
Sbjct: 1831 SSAPASAPAPTPILASVSTPASVTI---LASASIPILASALASTSAPTPA---------- 1877

Query: 238  DQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAP 297
               P   SP +P+  +P+ PA +    V  APA+ SA A   +PV    S P   P +  
Sbjct: 1878 ---PAASSPAAPVITAPTIPASAPTASVPLAPASASAPAPAPTPV----SAPNPAPPAPA 1930

Query: 298  KTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ 357
            +T  ++ K P  +P  T  ++S  P       P S      Q P     ++ A+  S Q 
Sbjct: 1931 QTQAQTHK-PVQNPLQTTSQSSKQP-------PPSIRLPSAQTP--NGTDYVASGKSIQT 1980

Query: 358  ARSYGERLKELSEN 371
             +S+G    EL +N
Sbjct: 1981 PQSHGTLTAELWDN 1994



 Score = 37.0 bits (84), Expect = 0.062
 Identities = 35/120 (29%), Positives = 52/120 (43%), Gaps = 11/120 (9%)

Query: 214  SDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPA-YSTVTRVHAAPAAP 272
            S   P   S P P  +  S   S      L + ++P+  S S+P   ST+  V A+ +AP
Sbjct: 1743 SASVPPLASAPLPPSTSASVPASTSA--PLPATLTPVPASTSAPVPASTLAPVLASTSAP 1800

Query: 273  SATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDS 332
               A P +PV+  +S     P S       S   P ++P       +P+P L+S S P S
Sbjct: 1801 -VPASPLAPVSASASVSASVPASTSAAAITSSSAPASAP-------APTPILASVSTPAS 1852



 Score = 33.1 bits (74), Expect = 0.90
 Identities = 27/87 (31%), Positives = 42/87 (48%), Gaps = 9/87 (10%)

Query: 218  PTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISES-------PSSPAYSTVTRVHAAPA 270
            P STS P P  ++    L+    P   SP++P+S S       P+S + + +T   A  +
Sbjct: 1778 PASTSAPVPASTLAP-VLASTSAPVPASPLAPVSASASVSASVPASTSAAAITSSSAPAS 1836

Query: 271  APSATALPASPVARRSSEPQLCPGSAP 297
            AP+ T + AS V+  +S   L   S P
Sbjct: 1837 APAPTPILAS-VSTPASVTILASASIP 1862


>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
           sapiens]
          Length = 217

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 29/100 (29%), Positives = 55/100 (55%), Gaps = 11/100 (11%)

Query: 54  DLRSHAWYHGRIPREVSETLVQR---NGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKV 110
           +++ H W+ G+IPR  +E ++ +   +G FLIR+S ++ GD+ L+ ++ N   HFK    
Sbjct: 54  EMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFK---- 109

Query: 111 VVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQ 150
           V++ G      +Y      F+ +  LV YH  +  + ++Q
Sbjct: 110 VLRDGAG----KYFLWVVKFNSLNELVDYHRSTSVSRNQQ 145


>gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
           [Homo sapiens]
          Length = 304

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 31/95 (32%), Positives = 50/95 (52%), Gaps = 15/95 (15%)

Query: 59  AWYHGRIPREVSETLVQ--RNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINK------- 109
           +WY GR+ R+ +  L+Q  R+G FL+RDS TS GDYVL+    ++  H+ IN        
Sbjct: 12  SWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPV 71

Query: 110 ----VVVKAGESYTHIQYLFEQESFDHVPALVRYH 140
                    G S + ++     + FD +PAL+ ++
Sbjct: 72  PPSPAQPPPGVSPSRLR--IGDQEFDSLPALLEFY 104


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.130    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,828,688
Number of Sequences: 37866
Number of extensions: 1493858
Number of successful extensions: 8575
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 96
Number of HSP's successfully gapped in prelim test: 524
Number of HSP's that attempted gapping in prelim test: 7262
Number of HSP's gapped (non-prelim): 1514
length of query: 700
length of database: 18,247,518
effective HSP length: 109
effective length of query: 591
effective length of database: 14,120,124
effective search space: 8344993284
effective search space used: 8344993284
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.