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Search of human proteins with 21450838
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21450838 SH3 and cysteine rich domain 3 [Homo sapiens]
(364 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21450838 SH3 and cysteine rich domain 3 [Homo sapiens] 759 0.0
gi|4507247 SH3 and cysteine rich domain [Homo sapiens] 234 9e-62
gi|39752673 SH3 and cysteine rich domain 2 [Homo sapiens] 209 4e-54
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 60 4e-09
gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens] 58 2e-08
gi|189083742 neutrophil cytosolic factor 2 [Homo sapiens] 56 4e-08
gi|67189970 neutrophil cytosolic factor 2 [Homo sapiens] 56 4e-08
gi|39930351 dynamin binding protein [Homo sapiens] 56 6e-08
gi|188219625 signal transducing adaptor molecule 2 [Homo sapiens] 55 1e-07
gi|227430338 SH3 domain containing, Ysc84-like 1 isoform 2 [Homo... 55 1e-07
gi|227430336 SH3 domain containing, Ysc84-like 1 isoform 1 [Homo... 55 1e-07
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 54 3e-07
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 54 3e-07
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 54 3e-07
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 53 5e-07
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 53 5e-07
gi|28557781 protein kinase C, eta [Homo sapiens] 52 8e-07
gi|5453976 protein kinase C, theta [Homo sapiens] 51 1e-06
gi|4885563 protein kinase C, epsilon [Homo sapiens] 51 2e-06
gi|47157325 protein kinase C, delta [Homo sapiens] 50 2e-06
gi|31377782 protein kinase C, delta [Homo sapiens] 50 2e-06
gi|4503787 fyn-related kinase [Homo sapiens] 50 3e-06
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 49 5e-06
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 49 5e-06
gi|20357552 cortactin isoform a [Homo sapiens] 49 5e-06
gi|20357556 cortactin isoform b [Homo sapiens] 49 5e-06
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 49 7e-06
gi|11321634 CD2-associated protein [Homo sapiens] 49 9e-06
gi|5031689 protein kinase D3 [Homo sapiens] 48 1e-05
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 48 1e-05
>gi|21450838 SH3 and cysteine rich domain 3 [Homo sapiens]
Length = 364
Score = 759 bits (1960), Expect = 0.0
Identities = 364/364 (100%), Positives = 364/364 (100%)
Query: 1 MTEKEVLESPKPSFPAETRQSGLQRLKQLLRKGSTGTKEMELPPEPQANGEAVGAGGGPI 60
MTEKEVLESPKPSFPAETRQSGLQRLKQLLRKGSTGTKEMELPPEPQANGEAVGAGGGPI
Sbjct: 1 MTEKEVLESPKPSFPAETRQSGLQRLKQLLRKGSTGTKEMELPPEPQANGEAVGAGGGPI 60
Query: 61 YYIYEEEEEEEEEEEEPPPEPPKLVNDKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRC 120
YYIYEEEEEEEEEEEEPPPEPPKLVNDKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRC
Sbjct: 61 YYIYEEEEEEEEEEEEPPPEPPKLVNDKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRC 120
Query: 121 KNCKTNIHEHCQSYVEMQRCFGKIPPGFHRAYSSPLYSNQQYACVKDLSAANRNDPVFET 180
KNCKTNIHEHCQSYVEMQRCFGKIPPGFHRAYSSPLYSNQQYACVKDLSAANRNDPVFET
Sbjct: 121 KNCKTNIHEHCQSYVEMQRCFGKIPPGFHRAYSSPLYSNQQYACVKDLSAANRNDPVFET 180
Query: 181 LRTGVIMANKERKKGQADKKNPVAAMMEEEPESARPEEGKPQDGNPEGDKKAEKKTPDDK 240
LRTGVIMANKERKKGQADKKNPVAAMMEEEPESARPEEGKPQDGNPEGDKKAEKKTPDDK
Sbjct: 181 LRTGVIMANKERKKGQADKKNPVAAMMEEEPESARPEEGKPQDGNPEGDKKAEKKTPDDK 240
Query: 241 HKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNF 300
HKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNF
Sbjct: 241 HKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNF 300
Query: 301 IIRVRAGERVHRVTRSFVGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLFPTDF 360
IIRVRAGERVHRVTRSFVGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLFPTDF
Sbjct: 301 IIRVRAGERVHRVTRSFVGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLFPTDF 360
Query: 361 LEEI 364
LEEI
Sbjct: 361 LEEI 364
>gi|4507247 SH3 and cysteine rich domain [Homo sapiens]
Length = 402
Score = 234 bits (597), Expect = 9e-62
Identities = 143/398 (35%), Positives = 209/398 (52%), Gaps = 49/398 (12%)
Query: 4 KEVLESPKPSFPAET--RQSGLQRLKQLLRKGSTGTKEMELPPEP----QANGEAVGAGG 57
KE + + +P PA T ++S LQ+LK+ L S TK + + N E +
Sbjct: 17 KEAVGAEQPPSPASTSSQESKLQKLKRSL---SFKTKSLRSKSADNFFQRTNSEDMKLQA 73
Query: 58 GPIYYIYEEEEEEEEEEEEPPPEPPKLVND----------KPHKFKDHFFKKPKFCDVCA 107
+ E P P P L + K H F+++ FKKP FCDVC
Sbjct: 74 HMV--------AEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFQEYIFKKPTFCDVCN 125
Query: 108 RMIV-LNNKFGLRCKNCKTNIHEHCQSYVEMQRCFGKIPPGFHRAYSSPLYSNQQYACVK 166
MIV N K GLRCK CK +IH C + QRC GK+P GF R YSSPL ++Q+ C+K
Sbjct: 126 HMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQFGCIK 185
Query: 167 D---LSAANRNDPVFETLRTGVIMANKERK----KGQADKKNPVAAMMEEEPESARPEEG 219
+ ++ N+ DPV+ETLR G +A + +K G + + E PE A G
Sbjct: 186 EVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEANGPGG 245
Query: 220 K-------------PQDGNPEGDKKAEKKTPDDKHKQPGFQQSHYFVALYRFKALEKDDL 266
P++G + A+ + Q + Y VALY+F E +DL
Sbjct: 246 GYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTY-VALYKFVPQENEDL 304
Query: 267 DFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSFVGNREIGQI 326
+ PG+ IT+++DSNE+WW+GKI +++GFFP NF+ R++ E++ R R+F+G +E GQI
Sbjct: 305 EMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKEQGQI 364
Query: 327 TLKKDQIVVQKGDEAGGYVKVYTGRKVGLFPTDFLEEI 364
TLK++QI V +E G+++V +G+K GL P D LE I
Sbjct: 365 TLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI 402
>gi|39752673 SH3 and cysteine rich domain 2 [Homo sapiens]
Length = 411
Score = 209 bits (531), Expect = 4e-54
Identities = 120/317 (37%), Positives = 173/317 (54%), Gaps = 29/317 (9%)
Query: 77 PPPEPPKLVNDKP---HKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQS 133
P P P L KP H F++H FK+ C++C ++IV N+K GLRCK CK ++H C
Sbjct: 95 PCPVPRPLAALKPVRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSE 154
Query: 134 YVEMQRCFGKIPPGFHRAYSSPLYSNQQY-ACVKDLSA-----ANRNDPVFETLRTGVIM 187
+ Q+C GK F R +SSPL ++ C + + + DPV+ETLR G +
Sbjct: 155 EISHQQCPGKTSTSFRRNFSSPLLVHEPPPVCATSKESPPTGDSGKVDPVYETLRYGTSL 214
Query: 188 ANKERKKGQADKKNPVAAMMEE-------EPESARPEEGKPQDGNPEGDKKAEKKTPDDK 240
A R + ++P ++ E E EEG +P AE + P +
Sbjct: 215 ALMNRSSFSSTSESPTRSLSERDELTEDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPE 274
Query: 241 HKQPGFQ-----------QSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKI 289
K PG Q + +VALY+F E +DL PG++I ++DDSNE+WW+GKI
Sbjct: 275 EKSPGQQLPKATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKI 334
Query: 290 GEKVGFFPPNFIIRVRAGERVHRVTRSFVGNREIGQITLKKDQIVVQKG--DEAGGYVKV 347
G++VGFFP NF+ RVR GE V R + F GN+E G ++LK++QI V G +A G+++V
Sbjct: 335 GDRVGFFPANFVQRVRPGENVWRCCQPFSGNKEQGYMSLKENQICVGVGRSKDADGFIRV 394
Query: 348 YTGRKVGLFPTDFLEEI 364
+G+K GL P D L EI
Sbjct: 395 SSGKKRGLVPVDALTEI 411
>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
Length = 330
Score = 59.7 bits (143), Expect = 4e-09
Identities = 24/48 (50%), Positives = 33/48 (68%)
Query: 254 ALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFI 301
ALY F+ALE D+L F GE + V+D SN WW G++ K+G FP N++
Sbjct: 278 ALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYV 325
Score = 39.7 bits (91), Expect = 0.004
Identities = 17/49 (34%), Positives = 31/49 (63%), Gaps = 1/49 (2%)
Query: 253 VALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFI 301
VA + F A +D+L F G+ + ++ + EEW++ ++G + G+ P NFI
Sbjct: 4 VAKFDFTASGEDELSFHTGDVLKILSNQ-EEWFKAELGSQEGYVPKNFI 51
>gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens]
Length = 540
Score = 57.8 bits (138), Expect = 2e-08
Identities = 23/48 (47%), Positives = 34/48 (70%)
Query: 254 ALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFI 301
A+Y F+A E ++L F GE ITV+DDS+ WW+G+ + +G FP NF+
Sbjct: 217 AIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
>gi|189083742 neutrophil cytosolic factor 2 [Homo sapiens]
Length = 526
Score = 56.2 bits (134), Expect = 4e-08
Identities = 26/78 (33%), Positives = 45/78 (57%)
Query: 224 GNPEGDKKAEKKTPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEE 283
G P+ K++EK +++ +P ++ AL+ ++A + +DL+F G+ I V+ NEE
Sbjct: 434 GFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQEGDIILVLSKVNEE 493
Query: 284 WWRGKIGEKVGFFPPNFI 301
W G+ KVG FP F+
Sbjct: 494 WLEGECKGKVGIFPKVFV 511
Score = 28.9 bits (63), Expect = 7.6
Identities = 32/136 (23%), Positives = 54/136 (39%), Gaps = 11/136 (8%)
Query: 176 PVFETLRTGVIMANKERKKGQADKKNPVAAMMEEEPESARPEEGKPQDGNPEGDKKAEKK 235
PV + R + KK K VA++++++ S +PQ P K
Sbjct: 178 PVGKLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPL-QPQAAEPP----PRPK 232
Query: 236 TPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGF 295
TP+ G ++H L+ F K++L PG + V+ N+ W + G
Sbjct: 233 TPEIFRALEG--EAHR--VLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGL 288
Query: 296 FPPNFIIRVRAGERVH 311
P N++ V R+H
Sbjct: 289 VPCNYLEPVEL--RIH 302
>gi|67189970 neutrophil cytosolic factor 2 [Homo sapiens]
Length = 526
Score = 56.2 bits (134), Expect = 4e-08
Identities = 26/78 (33%), Positives = 45/78 (57%)
Query: 224 GNPEGDKKAEKKTPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEE 283
G P+ K++EK +++ +P ++ AL+ ++A + +DL+F G+ I V+ NEE
Sbjct: 434 GFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQEGDIILVLSKVNEE 493
Query: 284 WWRGKIGEKVGFFPPNFI 301
W G+ KVG FP F+
Sbjct: 494 WLEGECKGKVGIFPKVFV 511
Score = 28.9 bits (63), Expect = 7.6
Identities = 32/136 (23%), Positives = 54/136 (39%), Gaps = 11/136 (8%)
Query: 176 PVFETLRTGVIMANKERKKGQADKKNPVAAMMEEEPESARPEEGKPQDGNPEGDKKAEKK 235
PV + R + KK K VA++++++ S +PQ P K
Sbjct: 178 PVGKLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPL-QPQAAEPP----PRPK 232
Query: 236 TPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGF 295
TP+ G ++H L+ F K++L PG + V+ N+ W + G
Sbjct: 233 TPEIFRALEG--EAHR--VLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGL 288
Query: 296 FPPNFIIRVRAGERVH 311
P N++ V R+H
Sbjct: 289 VPCNYLEPVEL--RIH 302
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 55.8 bits (133), Expect = 6e-08
Identities = 27/69 (39%), Positives = 41/69 (59%), Gaps = 4/69 (5%)
Query: 233 EKKTPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEK 292
E+ PD+ ++PG Y VALYRF+ALE ++LDF G+KI ++ + W G + +
Sbjct: 233 EEIGPDEDEEEPGT----YGVALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGR 288
Query: 293 VGFFPPNFI 301
G FP F+
Sbjct: 289 TGIFPYRFV 297
Score = 42.7 bits (99), Expect = 5e-04
Identities = 19/74 (25%), Positives = 38/74 (51%), Gaps = 7/74 (9%)
Query: 235 KTPDDKHKQPGFQQSH---YFVALYRFKALEKDDLDFPPGEKITVID----DSNEEWWRG 287
+ P+D+ +P ++ + A+Y FKA ++L +K+ +++ N EWW
Sbjct: 1498 QAPEDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLA 1557
Query: 288 KIGEKVGFFPPNFI 301
++ K G+ P N+I
Sbjct: 1558 EVNGKKGYVPSNYI 1571
Score = 34.3 bits (77), Expect = 0.18
Identities = 30/120 (25%), Positives = 55/120 (45%), Gaps = 13/120 (10%)
Query: 254 ALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNF-----IIRVRAGE 308
A++ F ++L G+ I V+ +E W GK + G FP +F I ++ GE
Sbjct: 9 AIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLKEGE 68
Query: 309 RVHRVTRSFVGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKV----GLFPTDFLEEI 364
R+ F ++E+ + L + +V+ G G+++ GR G FP+ + E+
Sbjct: 69 RLFVCICEFT-SQELDNLPLHRGDLVILDGIPTAGWLQ---GRSCWGARGFFPSSCVREL 124
Score = 34.3 bits (77), Expect = 0.18
Identities = 16/48 (33%), Positives = 25/48 (52%)
Query: 254 ALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFI 301
AL A ++LDF G+ IT+I W+ G++ + G FP F+
Sbjct: 152 ALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFV 199
>gi|188219625 signal transducing adaptor molecule 2 [Homo sapiens]
Length = 525
Score = 55.1 bits (131), Expect = 1e-07
Identities = 23/48 (47%), Positives = 33/48 (68%)
Query: 254 ALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFI 301
ALY F+A+E ++L F GE I V+DDS+ WW+G+ +G FP NF+
Sbjct: 209 ALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFV 256
>gi|227430338 SH3 domain containing, Ysc84-like 1 isoform 2 [Homo
sapiens]
Length = 323
Score = 54.7 bits (130), Expect = 1e-07
Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 6/113 (5%)
Query: 191 ERKKGQADKKNPVAAMMEEEPESARPEEGKPQDGNPEGDKKAEKKTPDDKHKQPGFQQSH 250
E+ + + + N A E+ SA+ KP + + + Q Q
Sbjct: 212 EKYENEGQRINARKAAREQRKSSAKELPPKPLSRPQQSSAPVQLNSGS----QSNLNQPI 267
Query: 251 YFVALYRFKALEKDDLDFPPGEKITVID--DSNEEWWRGKIGEKVGFFPPNFI 301
ALY F+ + DL+F G++ITVI DS+ +WW GK+ + G FP N++
Sbjct: 268 EVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGQTGIFPANYV 320
>gi|227430336 SH3 domain containing, Ysc84-like 1 isoform 1 [Homo
sapiens]
Length = 342
Score = 54.7 bits (130), Expect = 1e-07
Identities = 36/128 (28%), Positives = 56/128 (43%), Gaps = 17/128 (13%)
Query: 191 ERKKGQADKKNPVAAMMEEEPESARPEEGKP-----QDGNPEGDKKAEKKTPDDKHKQPG 245
E+ + + + N A E+ SA+ KP Q P + ++ PG
Sbjct: 212 EKYENEGQRINARKAAREQRKSSAKELPPKPLSRPQQSSAPVQLNSGSQSNRNEYKLYPG 271
Query: 246 FQQSHYFV----------ALYRFKALEKDDLDFPPGEKITVID--DSNEEWWRGKIGEKV 293
H V ALY F+ + DL+F G++ITVI DS+ +WW GK+ +
Sbjct: 272 LSSYHERVGNLNQPIEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGQT 331
Query: 294 GFFPPNFI 301
G FP N++
Sbjct: 332 GIFPANYV 339
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 53.5 bits (127), Expect = 3e-07
Identities = 27/78 (34%), Positives = 46/78 (58%), Gaps = 4/78 (5%)
Query: 252 FVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVH 311
++ALY + ++E DL F GE+I ++ + EWW G IG++ G FP N+ ++ + E
Sbjct: 959 YIALYPYSSVEPGDLTFTEGEEI-LVTQKDGEWWTGSIGDRSGIFPSNY-VKPKDQESFG 1016
Query: 312 RVTRSFVGNR--EIGQIT 327
++S N+ EI Q+T
Sbjct: 1017 SASKSGASNKKPEIAQVT 1034
Score = 51.6 bits (122), Expect = 1e-06
Identities = 20/65 (30%), Positives = 35/65 (53%)
Query: 237 PDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFF 296
P + P F +A+Y + A +D+L F G+ I V++ + +WW+G+I G F
Sbjct: 1090 PSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLF 1149
Query: 297 PPNFI 301
P N++
Sbjct: 1150 PSNYV 1154
Score = 46.6 bits (109), Expect = 4e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 9/116 (7%)
Query: 208 EEEPESARPEEGKPQDGNPEGDKKAEKKTPDDKHKQPGFQQSH-------YFVALYRFKA 260
EEE + R +E K Q+ E ++KAE+K DK ++ + ALY F+A
Sbjct: 684 EEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEA 743
Query: 261 LEKDDLDFPPGEKITVIDDSNEE--WWRGKIGEKVGFFPPNFIIRVRAGERVHRVT 314
D++ F G+ I V + + E W G G+FP N++ ++ + E V+
Sbjct: 744 RNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVS 799
Score = 32.3 bits (72), Expect = 0.68
Identities = 18/59 (30%), Positives = 33/59 (55%), Gaps = 2/59 (3%)
Query: 254 ALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHR 312
AL + A + + L+F + ITV++ E WW G++ G+FP ++ +++ G V R
Sbjct: 878 ALCSWTAKKDNHLNFSKHDIITVLEQQ-ENWWFGEVHGGRGWFPKSY-VKIIPGSEVKR 934
Score = 31.6 bits (70), Expect = 1.2
Identities = 28/121 (23%), Positives = 56/121 (46%), Gaps = 18/121 (14%)
Query: 258 FKALEKDDLDFPPGEKITVIDDSNEEWWRGKI---GEK--VGFFPPNFIIRV-----RAG 307
+ A + L PG+ I ++ + WW+G++ G+K G+FP + + + RA
Sbjct: 1037 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERAT 1096
Query: 308 ERVHRVTR-----SFVGNREIGQITLKKDQIV-VQKGDEAGGYVKVYTGRKVGLFPTDFL 361
H V + + N E +++ K Q++ V D+ + G GLFP++++
Sbjct: 1097 PAFHPVCQVIAMYDYAANNE-DELSFSKGQLINVMNKDDPDWWQGEING-VTGLFPSNYV 1154
Query: 362 E 362
+
Sbjct: 1155 K 1155
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 53.5 bits (127), Expect = 3e-07
Identities = 27/78 (34%), Positives = 46/78 (58%), Gaps = 4/78 (5%)
Query: 252 FVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVH 311
++ALY + ++E DL F GE+I ++ + EWW G IG++ G FP N+ ++ + E
Sbjct: 986 YIALYPYSSVEPGDLTFTEGEEI-LVTQKDGEWWTGSIGDRSGIFPSNY-VKPKDQESFG 1043
Query: 312 RVTRSFVGNR--EIGQIT 327
++S N+ EI Q+T
Sbjct: 1044 SASKSGASNKKPEIAQVT 1061
Score = 51.6 bits (122), Expect = 1e-06
Identities = 20/65 (30%), Positives = 35/65 (53%)
Query: 237 PDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFF 296
P + P F +A+Y + A +D+L F G+ I V++ + +WW+G+I G F
Sbjct: 1117 PSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLF 1176
Query: 297 PPNFI 301
P N++
Sbjct: 1177 PSNYV 1181
Score = 46.6 bits (109), Expect = 4e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 9/116 (7%)
Query: 208 EEEPESARPEEGKPQDGNPEGDKKAEKKTPDDKHKQPGFQQSH-------YFVALYRFKA 260
EEE + R +E K Q+ E ++KAE+K DK ++ + ALY F+A
Sbjct: 711 EEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEA 770
Query: 261 LEKDDLDFPPGEKITVIDDSNEE--WWRGKIGEKVGFFPPNFIIRVRAGERVHRVT 314
D++ F G+ I V + + E W G G+FP N++ ++ + E V+
Sbjct: 771 RNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVS 826
Score = 32.3 bits (72), Expect = 0.68
Identities = 18/59 (30%), Positives = 33/59 (55%), Gaps = 2/59 (3%)
Query: 254 ALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHR 312
AL + A + + L+F + ITV++ E WW G++ G+FP ++ +++ G V R
Sbjct: 905 ALCSWTAKKDNHLNFSKHDIITVLEQQ-ENWWFGEVHGGRGWFPKSY-VKIIPGSEVKR 961
Score = 31.6 bits (70), Expect = 1.2
Identities = 28/121 (23%), Positives = 56/121 (46%), Gaps = 18/121 (14%)
Query: 258 FKALEKDDLDFPPGEKITVIDDSNEEWWRGKI---GEK--VGFFPPNFIIRV-----RAG 307
+ A + L PG+ I ++ + WW+G++ G+K G+FP + + + RA
Sbjct: 1064 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERAT 1123
Query: 308 ERVHRVTR-----SFVGNREIGQITLKKDQIV-VQKGDEAGGYVKVYTGRKVGLFPTDFL 361
H V + + N E +++ K Q++ V D+ + G GLFP++++
Sbjct: 1124 PAFHPVCQVIAMYDYAANNE-DELSFSKGQLINVMNKDDPDWWQGEING-VTGLFPSNYV 1181
Query: 362 E 362
+
Sbjct: 1182 K 1182
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 53.5 bits (127), Expect = 3e-07
Identities = 27/78 (34%), Positives = 46/78 (58%), Gaps = 4/78 (5%)
Query: 252 FVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVH 311
++ALY + ++E DL F GE+I ++ + EWW G IG++ G FP N+ ++ + E
Sbjct: 986 YIALYPYSSVEPGDLTFTEGEEI-LVTQKDGEWWTGSIGDRSGIFPSNY-VKPKDQESFG 1043
Query: 312 RVTRSFVGNR--EIGQIT 327
++S N+ EI Q+T
Sbjct: 1044 SASKSGASNKKPEIAQVT 1061
Score = 51.6 bits (122), Expect = 1e-06
Identities = 20/65 (30%), Positives = 35/65 (53%)
Query: 237 PDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFF 296
P + P F +A+Y + A +D+L F G+ I V++ + +WW+G+I G F
Sbjct: 1117 PSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLF 1176
Query: 297 PPNFI 301
P N++
Sbjct: 1177 PSNYV 1181
Score = 46.6 bits (109), Expect = 4e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 9/116 (7%)
Query: 208 EEEPESARPEEGKPQDGNPEGDKKAEKKTPDDKHKQPGFQQSH-------YFVALYRFKA 260
EEE + R +E K Q+ E ++KAE+K DK ++ + ALY F+A
Sbjct: 711 EEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEA 770
Query: 261 LEKDDLDFPPGEKITVIDDSNEE--WWRGKIGEKVGFFPPNFIIRVRAGERVHRVT 314
D++ F G+ I V + + E W G G+FP N++ ++ + E V+
Sbjct: 771 RNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVS 826
Score = 32.3 bits (72), Expect = 0.68
Identities = 18/59 (30%), Positives = 33/59 (55%), Gaps = 2/59 (3%)
Query: 254 ALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHR 312
AL + A + + L+F + ITV++ E WW G++ G+FP ++ +++ G V R
Sbjct: 905 ALCSWTAKKDNHLNFSKHDIITVLEQQ-ENWWFGEVHGGRGWFPKSY-VKIIPGSEVKR 961
Score = 31.6 bits (70), Expect = 1.2
Identities = 28/121 (23%), Positives = 56/121 (46%), Gaps = 18/121 (14%)
Query: 258 FKALEKDDLDFPPGEKITVIDDSNEEWWRGKI---GEK--VGFFPPNFIIRV-----RAG 307
+ A + L PG+ I ++ + WW+G++ G+K G+FP + + + RA
Sbjct: 1064 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERAT 1123
Query: 308 ERVHRVTR-----SFVGNREIGQITLKKDQIV-VQKGDEAGGYVKVYTGRKVGLFPTDFL 361
H V + + N E +++ K Q++ V D+ + G GLFP++++
Sbjct: 1124 PAFHPVCQVIAMYDYAANNE-DELSFSKGQLINVMNKDDPDWWQGEING-VTGLFPSNYV 1181
Query: 362 E 362
+
Sbjct: 1182 K 1182
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 52.8 bits (125), Expect = 5e-07
Identities = 33/129 (25%), Positives = 63/129 (48%), Gaps = 19/129 (14%)
Query: 252 FVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFI-IRVRAGERV 310
F+A+Y +++ E+ DL F G+ I ++ + +WW G +G+K G FP N++ ++ G
Sbjct: 1007 FIAMYTYESSEQGDLTFQQGDVI-LVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGT 1065
Query: 311 HRVTRSFVGNREIGQI------------TLKKDQIVVQKGDEAGGYVKVY-----TGRKV 353
T S EI Q+ TL Q+++ + GG+ + R++
Sbjct: 1066 AGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 354 GLFPTDFLE 362
G FP ++++
Sbjct: 1126 GWFPANYVK 1134
Score = 49.7 bits (117), Expect = 4e-06
Identities = 20/68 (29%), Positives = 36/68 (52%)
Query: 234 KKTPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKV 293
K TP + K + +Y + A D+L F G+ I V++ + +WW+G++ +V
Sbjct: 1142 KITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQV 1201
Query: 294 GFFPPNFI 301
G FP N++
Sbjct: 1202 GLFPSNYV 1209
Score = 39.7 bits (91), Expect = 0.004
Identities = 31/133 (23%), Positives = 56/133 (42%), Gaps = 31/133 (23%)
Query: 207 MEEEPESARPEEGKPQDGNPEGDKKAEKKTPD--DKHKQPGFQQSH-------------- 250
+ EE + R E K +DG +G ++A+ K +H++P
Sbjct: 676 LHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTIS 735
Query: 251 --------YFVALYRFKALEKDDLDFPPGEKITV----IDDS---NEEWWRGKIGEKVGF 295
Y+ ALY F++ D++ PG+ + V +D+S W G++ K G+
Sbjct: 736 AQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGW 795
Query: 296 FPPNFIIRVRAGE 308
FP N+ ++ E
Sbjct: 796 FPANYAEKIPENE 808
Score = 35.8 bits (81), Expect = 0.062
Identities = 15/48 (31%), Positives = 31/48 (64%), Gaps = 1/48 (2%)
Query: 254 ALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFI 301
ALY ++A + + L+F + ITV++ + WW G++ + G+FP +++
Sbjct: 920 ALYPWRAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYV 966
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 52.8 bits (125), Expect = 5e-07
Identities = 33/129 (25%), Positives = 63/129 (48%), Gaps = 19/129 (14%)
Query: 252 FVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFI-IRVRAGERV 310
F+A+Y +++ E+ DL F G+ I ++ + +WW G +G+K G FP N++ ++ G
Sbjct: 1007 FIAMYTYESSEQGDLTFQQGDVI-LVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGT 1065
Query: 311 HRVTRSFVGNREIGQI------------TLKKDQIVVQKGDEAGGYVKVY-----TGRKV 353
T S EI Q+ TL Q+++ + GG+ + R++
Sbjct: 1066 AGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 354 GLFPTDFLE 362
G FP ++++
Sbjct: 1126 GWFPANYVK 1134
Score = 49.7 bits (117), Expect = 4e-06
Identities = 20/68 (29%), Positives = 36/68 (52%)
Query: 234 KKTPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKV 293
K TP + K + +Y + A D+L F G+ I V++ + +WW+G++ +V
Sbjct: 1142 KITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQV 1201
Query: 294 GFFPPNFI 301
G FP N++
Sbjct: 1202 GLFPSNYV 1209
Score = 39.7 bits (91), Expect = 0.004
Identities = 31/133 (23%), Positives = 56/133 (42%), Gaps = 31/133 (23%)
Query: 207 MEEEPESARPEEGKPQDGNPEGDKKAEKKTPD--DKHKQPGFQQSH-------------- 250
+ EE + R E K +DG +G ++A+ K +H++P
Sbjct: 676 LHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTIS 735
Query: 251 --------YFVALYRFKALEKDDLDFPPGEKITV----IDDS---NEEWWRGKIGEKVGF 295
Y+ ALY F++ D++ PG+ + V +D+S W G++ K G+
Sbjct: 736 AQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGW 795
Query: 296 FPPNFIIRVRAGE 308
FP N+ ++ E
Sbjct: 796 FPANYAEKIPENE 808
Score = 35.8 bits (81), Expect = 0.062
Identities = 15/48 (31%), Positives = 31/48 (64%), Gaps = 1/48 (2%)
Query: 254 ALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFI 301
ALY ++A + + L+F + ITV++ + WW G++ + G+FP +++
Sbjct: 920 ALYPWRAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYV 966
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 52.0 bits (123), Expect = 8e-07
Identities = 22/47 (46%), Positives = 29/47 (61%)
Query: 89 PHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYV 135
PHKF H +K P FCD C ++ + GL+CK CK N+H CQ+ V
Sbjct: 245 PHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANV 291
Score = 32.0 bits (71), Expect = 0.89
Identities = 13/47 (27%), Positives = 23/47 (48%), Gaps = 1/47 (2%)
Query: 90 HKFKDHFFKKPKFCDVCARMI-VLNNKFGLRCKNCKTNIHEHCQSYV 135
HKF + ++P +C C I + K G +C+ C +H+ C +
Sbjct: 172 HKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLI 218
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 51.2 bits (121), Expect = 1e-06
Identities = 29/91 (31%), Positives = 43/91 (47%), Gaps = 3/91 (3%)
Query: 87 DKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQRCFGKIPP 146
D PH+FK + +K P FC+ C ++ + GL+C C N+H CQ+ V C I
Sbjct: 229 DMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKV-ANLC--GINQ 285
Query: 147 GFHRAYSSPLYSNQQYACVKDLSAANRNDPV 177
+ + S QQ C++D R PV
Sbjct: 286 KLMAEALAMIESTQQARCLRDTEQIFREGPV 316
Score = 45.1 bits (105), Expect = 1e-04
Identities = 22/60 (36%), Positives = 32/60 (53%), Gaps = 1/60 (1%)
Query: 83 KLVNDKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQRCFG 142
K+ + K H+F FF +P FC VC + NK G +C+ C IH+ C V + +C G
Sbjct: 153 KVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKV-IAKCTG 211
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 50.8 bits (120), Expect = 2e-06
Identities = 21/47 (44%), Positives = 29/47 (61%)
Query: 89 PHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYV 135
PHKF H +K P FCD C ++ + GL+CK CK N+H C++ V
Sbjct: 242 PHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNV 288
Score = 32.7 bits (73), Expect = 0.52
Identities = 15/54 (27%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 90 HKFKDHFFKKPKFCDVCARMI-VLNNKFGLRCKNCKTNIHEHCQSYVEMQRCFG 142
HKF + ++P +C C I + K G +C+ C +H+ C + + +C G
Sbjct: 170 HKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELI-ITKCAG 222
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 50.4 bits (119), Expect = 2e-06
Identities = 20/49 (40%), Positives = 29/49 (59%)
Query: 87 DKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYV 135
D PH+FK H + P FCD C ++ K GL+C++C N+H C+ V
Sbjct: 228 DMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKV 276
Score = 44.3 bits (103), Expect = 2e-04
Identities = 21/55 (38%), Positives = 29/55 (52%), Gaps = 1/55 (1%)
Query: 88 KPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQRCFG 142
K H+F FF +P FC VC + NK G +C+ C IH+ C + + RC G
Sbjct: 157 KNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKI-IGRCTG 210
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 50.4 bits (119), Expect = 2e-06
Identities = 20/49 (40%), Positives = 29/49 (59%)
Query: 87 DKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYV 135
D PH+FK H + P FCD C ++ K GL+C++C N+H C+ V
Sbjct: 228 DMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKV 276
Score = 44.3 bits (103), Expect = 2e-04
Identities = 21/55 (38%), Positives = 29/55 (52%), Gaps = 1/55 (1%)
Query: 88 KPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQRCFG 142
K H+F FF +P FC VC + NK G +C+ C IH+ C + + RC G
Sbjct: 157 KNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKI-IGRCTG 210
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 50.1 bits (118), Expect = 3e-06
Identities = 27/89 (30%), Positives = 42/89 (47%), Gaps = 9/89 (10%)
Query: 227 EGDKKAEKKTPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWR 286
E DK + P + HYFVAL+ ++A +DL F G+K+ V+D +E WW
Sbjct: 22 EADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWF 81
Query: 287 GKIGEK---------VGFFPPNFIIRVRA 306
+ EK G+ P N++ R+
Sbjct: 82 ARHLEKRRDGSSQQLQGYIPSNYVAEDRS 110
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 49.3 bits (116), Expect = 5e-06
Identities = 36/145 (24%), Positives = 66/145 (45%), Gaps = 21/145 (14%)
Query: 210 EPESARPEEGKPQDGNPEGDKKAEKKTPDDKHKQP-GFQQSHYFVALYRFKALEKDDLDF 268
+P S+ + KP PE D+ +K P + P + VALY + + +DL
Sbjct: 176 KPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQL 235
Query: 269 PPGEKITVIDDSNEEWWRG--KIGEKVGFFPPNFIIRVRAGERVH-----RVTRSFVGNR 321
G++ ++++SN WWR K G++ G+ P N++ ++ +TRS
Sbjct: 236 RKGDEYFILEESNLPWWRARDKNGQE-GYIPSNYVTEAEDSIEMYEWYSKHMTRS----- 289
Query: 322 EIGQITLKKDQIVVQKGDEAGGYVK 346
+ +Q++ Q+G E G V+
Sbjct: 290 -------QAEQLLKQEGKEGGFIVR 307
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 49.3 bits (116), Expect = 5e-06
Identities = 30/99 (30%), Positives = 49/99 (49%), Gaps = 15/99 (15%)
Query: 216 PEEGKPQDGNPEGD----KKAEKKTPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPG 271
P K Q PE ++ + K P++ Q VALY + + DDL F G
Sbjct: 36 PTSNKQQRPVPESQLLPGQRFQTKDPEE--------QGDIVVALYPYDGIHPDDLSFKKG 87
Query: 272 EKITVIDDSNEEWWRGK--IGEKVGFFPPNFIIRVRAGE 308
EK+ V+++ + EWW+ K + +K GF P N++ ++ E
Sbjct: 88 EKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 125
>gi|20357552 cortactin isoform a [Homo sapiens]
Length = 550
Score = 49.3 bits (116), Expect = 5e-06
Identities = 39/142 (27%), Positives = 58/142 (40%), Gaps = 21/142 (14%)
Query: 176 PVFETLRTGVIMANKERKKGQADKKNPVAAMMEEEP----ESARPEEGKPQDG------- 224
P E L + + + K + + PV+ E EP E+A E Q G
Sbjct: 410 PTEERLPSSPVYEDAASFKAELSYRGPVSGT-EPEPVYSMEAADYREASSQQGLAYATEA 468
Query: 225 -----NPEGDKKAEKKTPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDD 279
G AE T D+ G VALY ++A D++ F P + IT I+
Sbjct: 469 VYESAEAPGHYPAEDSTYDEYENDLGITA----VALYDYQAAGDDEISFDPDDIITNIEM 524
Query: 280 SNEEWWRGKIGEKVGFFPPNFI 301
++ WWRG + G FP N++
Sbjct: 525 IDDGWWRGVCKGRYGLFPANYV 546
>gi|20357556 cortactin isoform b [Homo sapiens]
Length = 513
Score = 49.3 bits (116), Expect = 5e-06
Identities = 39/142 (27%), Positives = 58/142 (40%), Gaps = 21/142 (14%)
Query: 176 PVFETLRTGVIMANKERKKGQADKKNPVAAMMEEEP----ESARPEEGKPQDG------- 224
P E L + + + K + + PV+ E EP E+A E Q G
Sbjct: 373 PTEERLPSSPVYEDAASFKAELSYRGPVSGT-EPEPVYSMEAADYREASSQQGLAYATEA 431
Query: 225 -----NPEGDKKAEKKTPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDD 279
G AE T D+ G VALY ++A D++ F P + IT I+
Sbjct: 432 VYESAEAPGHYPAEDSTYDEYENDLGITA----VALYDYQAAGDDEISFDPDDIITNIEM 487
Query: 280 SNEEWWRGKIGEKVGFFPPNFI 301
++ WWRG + G FP N++
Sbjct: 488 IDDGWWRGVCKGRYGLFPANYV 509
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 48.9 bits (115), Expect = 7e-06
Identities = 23/64 (35%), Positives = 38/64 (59%), Gaps = 3/64 (4%)
Query: 247 QQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGK--IGEKVGFFPPNFIIRV 304
+Q VALY + + DDL F GEK+ V+++ + EWW+ K + +K GF P N++ ++
Sbjct: 42 EQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKL 100
Query: 305 RAGE 308
E
Sbjct: 101 NTLE 104
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 48.5 bits (114), Expect = 9e-06
Identities = 39/136 (28%), Positives = 56/136 (41%), Gaps = 12/136 (8%)
Query: 177 VFETLRTGVIMANKERKKGQADKKNPVAAMMEEEPESARPEEGKP------QDGNPEGDK 230
V ET V K R G D + + S+ EE KP Q P+
Sbjct: 197 VSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQS 256
Query: 231 KAEKKTPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEE--WWRGK 288
KT D + K + Y L+ ++ +D+L F GE I +I E WWRG+
Sbjct: 257 VEITKT-DTEGK---IKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGE 312
Query: 289 IGEKVGFFPPNFIIRV 304
+ K G FP NF +++
Sbjct: 313 LNGKEGVFPDNFAVQI 328
Score = 42.4 bits (98), Expect = 7e-04
Identities = 22/78 (28%), Positives = 37/78 (47%), Gaps = 4/78 (5%)
Query: 224 GNPEGDKKAEKKTPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEE 283
G P G + +T + K K Q L+ + +D+L+ G+ I + ++ E
Sbjct: 89 GLPAGGIQPHPQTKNIKKKTKKRQCK----VLFEYIPQNEDELELKVGDIIDINEEVEEG 144
Query: 284 WWRGKIGEKVGFFPPNFI 301
WW G + K+G FP NF+
Sbjct: 145 WWSGTLNNKLGLFPSNFV 162
Score = 33.9 bits (76), Expect = 0.23
Identities = 16/55 (29%), Positives = 28/55 (50%), Gaps = 1/55 (1%)
Query: 252 FVALYRFKALEKDDLDFPPGEKITVIDDSNEEWW-RGKIGEKVGFFPPNFIIRVR 305
++ Y + A+ D+L GE I + EE W G++ + G FP NF+ ++
Sbjct: 4 YIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIK 58
>gi|5031689 protein kinase D3 [Homo sapiens]
Length = 890
Score = 48.1 bits (113), Expect = 1e-05
Identities = 20/56 (35%), Positives = 32/56 (57%), Gaps = 1/56 (1%)
Query: 89 PHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQRCFGKI 144
PH F H + +P C C R++ + G++CK+CK N H+ C S V + C G++
Sbjct: 271 PHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVP-RDCLGEV 325
Score = 44.3 bits (103), Expect = 2e-04
Identities = 17/44 (38%), Positives = 24/44 (54%)
Query: 88 KPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHC 131
+PH H +K P FCD C M+ + GL+C+ C N H+ C
Sbjct: 153 RPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRC 196
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 48.1 bits (113), Expect = 1e-05
Identities = 34/109 (31%), Positives = 47/109 (43%), Gaps = 6/109 (5%)
Query: 89 PHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQ---RCFGKIP 145
PH F++ + KP FCD CA + K G RCK+C N H+ C+ V + R +
Sbjct: 506 PHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRAKNPVA 565
Query: 146 PGFHRAYSSPLYSNQQYACVKDLSAANRNDPVFETLRTGVIMANKERKK 194
P + P+ SN KDL A P T G + + E K
Sbjct: 566 PTENNTSVGPV-SNLCSLGAKDLLHAPEEGPF--TFPNGEAVEHGEESK 611
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.136 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,294,095
Number of Sequences: 37866
Number of extensions: 1078947
Number of successful extensions: 13964
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 396
Number of HSP's successfully gapped in prelim test: 251
Number of HSP's that attempted gapping in prelim test: 9634
Number of HSP's gapped (non-prelim): 3083
length of query: 364
length of database: 18,247,518
effective HSP length: 104
effective length of query: 260
effective length of database: 14,309,454
effective search space: 3720458040
effective search space used: 3720458040
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.