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Search of human proteins with 21264311
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21264311 membrane-spanning 4-domains, subfamily A, member 6E
[Homo sapiens]
(147 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21264311 membrane-spanning 4-domains, subfamily A, member 6E ... 286 6e-78
gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A ... 173 4e-44
gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A ... 173 4e-44
gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A ... 94 4e-20
gi|46249347 membrane-spanning 4-domains, subfamily A, member 7 i... 60 9e-10
gi|46249359 membrane-spanning 4-domains, subfamily A, member 7 i... 60 9e-10
gi|11139299 membrane-spanning 4-domains, subfamily A, member 7 i... 55 3e-08
gi|46249357 membrane-spanning 4-domains, subfamily A, member 7 i... 55 3e-08
gi|20070328 membrane-spanning 4-domains, subfamily A, member 4 i... 35 0.017
gi|23110995 membrane-spanning 4-domains, subfamily A, member 4 i... 35 0.017
gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A... 32 0.15
gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A... 32 0.15
gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A... 32 0.15
gi|73486649 membrane-spanning 4-domains, subfamily A, member 3 i... 32 0.15
gi|73486653 membrane-spanning 4-domains, subfamily A, member 3 i... 32 0.15
gi|29789060 hypothetical protein LOC9847 [Homo sapiens] 30 0.55
gi|190194363 dihydropyrimidinase-like 4 [Homo sapiens] 28 2.8
gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens] 28 2.8
gi|21218438 GATA zinc finger domain containing 2B [Homo sapiens] 28 3.6
gi|82659109 retinoblastoma-associated factor 600 [Homo sapiens] 27 8.0
>gi|21264311 membrane-spanning 4-domains, subfamily A, member 6E
[Homo sapiens]
Length = 147
Score = 286 bits (731), Expect = 6e-78
Identities = 147/147 (100%), Positives = 147/147 (100%)
Query: 1 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVHSSLAGSILS 60
MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVHSSLAGSILS
Sbjct: 1 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVHSSLAGSILS 60
Query: 61 ALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGT 120
ALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGT
Sbjct: 61 ALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGT 120
Query: 121 LSLMLVSTVLEFCLAVLTAVLQWKQTV 147
LSLMLVSTVLEFCLAVLTAVLQWKQTV
Sbjct: 121 LSLMLVSTVLEFCLAVLTAVLQWKQTV 147
>gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A
isoform 2 [Homo sapiens]
Length = 225
Score = 173 bits (439), Expect = 4e-44
Identities = 107/210 (50%), Positives = 123/210 (58%), Gaps = 65/210 (30%)
Query: 1 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVHSSLAGSILS 60
MTSQP+ NETII+LPSNVINFSQAEKPEPTNQGQDSLKK L A++KVIG L G ++
Sbjct: 1 MTSQPVPNETIIVLPSNVINFSQAEKPEPTNQGQDSLKKHLHAEIKVIGTIQILCGMMVL 60
Query: 61 AL-----------------------------------------------------SALVG 67
+L S+LVG
Sbjct: 61 SLGIILASASFSPNFTQVTSTLLNSAYPFIGPFFFIISGSLSIATEKRLTKLLVHSSLVG 120
Query: 68 FIL-----------LSVNPAALNPASLQCKLDEKDIPTRLLLSYDYH-SPYTMDCHRAKA 115
IL LSV A LNPASLQC+LD+ +IPTR +SY YH S YT DC+ AKA
Sbjct: 121 SILSALSALVGFIILSVKQATLNPASLQCELDKNNIPTRSYVSYFYHDSLYTTDCYTAKA 180
Query: 116 SLAGTLSLMLVSTVLEFCLAVLTAVLQWKQ 145
SLAGTLSLML+ T+LEFCLAVLTAVL+WKQ
Sbjct: 181 SLAGTLSLMLICTLLEFCLAVLTAVLRWKQ 210
>gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A
isoform 1 [Homo sapiens]
Length = 248
Score = 173 bits (439), Expect = 4e-44
Identities = 107/210 (50%), Positives = 123/210 (58%), Gaps = 65/210 (30%)
Query: 1 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVHSSLAGSILS 60
MTSQP+ NETII+LPSNVINFSQAEKPEPTNQGQDSLKK L A++KVIG L G ++
Sbjct: 1 MTSQPVPNETIIVLPSNVINFSQAEKPEPTNQGQDSLKKHLHAEIKVIGTIQILCGMMVL 60
Query: 61 AL-----------------------------------------------------SALVG 67
+L S+LVG
Sbjct: 61 SLGIILASASFSPNFTQVTSTLLNSAYPFIGPFFFIISGSLSIATEKRLTKLLVHSSLVG 120
Query: 68 FIL-----------LSVNPAALNPASLQCKLDEKDIPTRLLLSYDYH-SPYTMDCHRAKA 115
IL LSV A LNPASLQC+LD+ +IPTR +SY YH S YT DC+ AKA
Sbjct: 121 SILSALSALVGFIILSVKQATLNPASLQCELDKNNIPTRSYVSYFYHDSLYTTDCYTAKA 180
Query: 116 SLAGTLSLMLVSTVLEFCLAVLTAVLQWKQ 145
SLAGTLSLML+ T+LEFCLAVLTAVL+WKQ
Sbjct: 181 SLAGTLSLMLICTLLEFCLAVLTAVLRWKQ 210
>gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A
isoform 3 [Homo sapiens]
Length = 178
Score = 94.0 bits (232), Expect = 4e-20
Identities = 47/74 (63%), Positives = 56/74 (75%)
Query: 1 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVHSSLAGSILS 60
MTSQP+ NETII+LPSNVINFSQAEKPEPTNQGQDSLKK L A++KVIG L G ++
Sbjct: 1 MTSQPVPNETIIVLPSNVINFSQAEKPEPTNQGQDSLKKHLHAEIKVIGTIQILCGMMVL 60
Query: 61 ALSALVGFILLSVN 74
+L ++ S N
Sbjct: 61 SLGIILASASFSPN 74
Score = 58.2 bits (139), Expect = 2e-09
Identities = 32/49 (65%), Positives = 37/49 (75%)
Query: 36 SLKKRLQAKVKVIGVHSSLAGSILSALSALVGFILLSVNPAALNPASLQ 84
SL + ++ + VHSSL GSILSALSALVGFI+LSV A LNPASLQ
Sbjct: 100 SLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQ 148
>gi|46249347 membrane-spanning 4-domains, subfamily A, member 7
isoform 2 [Homo sapiens]
Length = 195
Score = 59.7 bits (143), Expect = 9e-10
Identities = 48/147 (32%), Positives = 66/147 (44%), Gaps = 21/147 (14%)
Query: 19 INFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVH-------------------SSLAGSIL 59
I Q EKP Q +D L+ L + V+G SSL + +
Sbjct: 19 ITIPQREKPGHMYQNEDYLQNGLPTETTVLGFGITGSLSIISGKQSTKPFDLSSLTSNAV 78
Query: 60 SALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPYTM-DCHRAKASLA 118
S+++A G LL+ + AL AS C E D + L S Y+ Y + DC SL
Sbjct: 79 SSVTAGAGLFLLADSMVALRTASQHCG-SEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLT 137
Query: 119 GTLSLMLVSTVLEFCLAVLTAVLQWKQ 145
G L +ML+ TVLE LA ++V WKQ
Sbjct: 138 GVLVVMLIFTVLELLLAAYSSVFWWKQ 164
>gi|46249359 membrane-spanning 4-domains, subfamily A, member 7
isoform 2 [Homo sapiens]
Length = 195
Score = 59.7 bits (143), Expect = 9e-10
Identities = 48/147 (32%), Positives = 66/147 (44%), Gaps = 21/147 (14%)
Query: 19 INFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVH-------------------SSLAGSIL 59
I Q EKP Q +D L+ L + V+G SSL + +
Sbjct: 19 ITIPQREKPGHMYQNEDYLQNGLPTETTVLGFGITGSLSIISGKQSTKPFDLSSLTSNAV 78
Query: 60 SALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPYTM-DCHRAKASLA 118
S+++A G LL+ + AL AS C E D + L S Y+ Y + DC SL
Sbjct: 79 SSVTAGAGLFLLADSMVALRTASQHCG-SEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLT 137
Query: 119 GTLSLMLVSTVLEFCLAVLTAVLQWKQ 145
G L +ML+ TVLE LA ++V WKQ
Sbjct: 138 GVLVVMLIFTVLELLLAAYSSVFWWKQ 164
>gi|11139299 membrane-spanning 4-domains, subfamily A, member 7
isoform 1 [Homo sapiens]
Length = 240
Score = 54.7 bits (130), Expect = 3e-08
Identities = 37/95 (38%), Positives = 51/95 (53%), Gaps = 2/95 (2%)
Query: 52 SSLAGSILSALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPYTM-DC 110
SSL + +S+++A G LL+ + AL AS C E D + L S Y+ Y + DC
Sbjct: 116 SSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCG-SEMDYLSSLPYSEYYYPIYEIKDC 174
Query: 111 HRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQ 145
SL G L +ML+ TVLE LA ++V WKQ
Sbjct: 175 LLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQ 209
Score = 31.2 bits (69), Expect = 0.33
Identities = 20/63 (31%), Positives = 31/63 (49%), Gaps = 3/63 (4%)
Query: 19 INFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVHSSLAGSILSALSALVGFILLSVNPAAL 78
I Q EKP Q +D L+ L + V+G L ++S+L A++ F + P+
Sbjct: 19 ITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVF---APYPSHF 75
Query: 79 NPA 81
NPA
Sbjct: 76 NPA 78
>gi|46249357 membrane-spanning 4-domains, subfamily A, member 7
isoform 1 [Homo sapiens]
Length = 240
Score = 54.7 bits (130), Expect = 3e-08
Identities = 37/95 (38%), Positives = 51/95 (53%), Gaps = 2/95 (2%)
Query: 52 SSLAGSILSALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPYTM-DC 110
SSL + +S+++A G LL+ + AL AS C E D + L S Y+ Y + DC
Sbjct: 116 SSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCG-SEMDYLSSLPYSEYYYPIYEIKDC 174
Query: 111 HRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQ 145
SL G L +ML+ TVLE LA ++V WKQ
Sbjct: 175 LLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQ 209
Score = 31.2 bits (69), Expect = 0.33
Identities = 20/63 (31%), Positives = 31/63 (49%), Gaps = 3/63 (4%)
Query: 19 INFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVHSSLAGSILSALSALVGFILLSVNPAAL 78
I Q EKP Q +D L+ L + V+G L ++S+L A++ F + P+
Sbjct: 19 ITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVF---APYPSHF 75
Query: 79 NPA 81
NPA
Sbjct: 76 NPA 78
>gi|20070328 membrane-spanning 4-domains, subfamily A, member 4
isoform a [Homo sapiens]
Length = 220
Score = 35.4 bits (80), Expect = 0.017
Identities = 25/96 (26%), Positives = 45/96 (46%), Gaps = 13/96 (13%)
Query: 47 VIGVHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPY 106
+I S+A I + + G + +++ + L + + I T L Y +H PY
Sbjct: 93 IISGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGIL-------INTFSLAFYSFHHPY 145
Query: 107 ------TMDCHRAKASLAGTLSLMLVSTVLEFCLAV 136
+ +CH + L G ++L+ +VLEFC+AV
Sbjct: 146 CNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIAV 181
>gi|23110995 membrane-spanning 4-domains, subfamily A, member 4
isoform b [Homo sapiens]
Length = 239
Score = 35.4 bits (80), Expect = 0.017
Identities = 25/96 (26%), Positives = 45/96 (46%), Gaps = 13/96 (13%)
Query: 47 VIGVHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPY 106
+I S+A I + + G + +++ + L + + I T L Y +H PY
Sbjct: 112 IISGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGIL-------INTFSLAFYSFHHPY 164
Query: 107 ------TMDCHRAKASLAGTLSLMLVSTVLEFCLAV 136
+ +CH + L G ++L+ +VLEFC+AV
Sbjct: 165 CNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIAV 200
>gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 1 [Homo sapiens]
Length = 243
Score = 32.3 bits (72), Expect = 0.15
Identities = 14/37 (37%), Positives = 23/37 (62%)
Query: 100 YDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAV 136
Y H + +C+ + L GT ++L+ +VLEFC+AV
Sbjct: 168 YCNHDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIAV 204
>gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 3 [Homo sapiens]
Length = 243
Score = 32.3 bits (72), Expect = 0.15
Identities = 14/37 (37%), Positives = 23/37 (62%)
Query: 100 YDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAV 136
Y H + +C+ + L GT ++L+ +VLEFC+AV
Sbjct: 168 YCNHDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIAV 204
>gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 3 [Homo sapiens]
Length = 243
Score = 32.3 bits (72), Expect = 0.15
Identities = 14/37 (37%), Positives = 23/37 (62%)
Query: 100 YDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAV 136
Y H + +C+ + L GT ++L+ +VLEFC+AV
Sbjct: 168 YCNHDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIAV 204
>gi|73486649 membrane-spanning 4-domains, subfamily A, member 3
isoform a [Homo sapiens]
Length = 214
Score = 32.3 bits (72), Expect = 0.15
Identities = 26/92 (28%), Positives = 42/92 (45%), Gaps = 15/92 (16%)
Query: 50 VHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPYTMD 109
+ +S +I SA ALVG LS+N A+N SL+ + P
Sbjct: 118 IQNSFGMNIASATIALVGTAFLSLN-IAVNIQSLRSCHSSSESPDL-------------- 162
Query: 110 CHRAKASLAGTLSLMLVSTVLEFCLAVLTAVL 141
C+ + G +SL+L+ T+LE C+ + T +
Sbjct: 163 CNYMGSISNGMVSLLLILTLLELCVTISTIAM 194
>gi|73486653 membrane-spanning 4-domains, subfamily A, member 3
isoform b [Homo sapiens]
Length = 168
Score = 32.3 bits (72), Expect = 0.15
Identities = 26/92 (28%), Positives = 42/92 (45%), Gaps = 15/92 (16%)
Query: 50 VHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPYTMD 109
+ +S +I SA ALVG LS+N A+N SL+ + P
Sbjct: 72 IQNSFGMNIASATIALVGTAFLSLN-IAVNIQSLRSCHSSSESPDL-------------- 116
Query: 110 CHRAKASLAGTLSLMLVSTVLEFCLAVLTAVL 141
C+ + G +SL+L+ T+LE C+ + T +
Sbjct: 117 CNYMGSISNGMVSLLLILTLLELCVTISTIAM 148
>gi|29789060 hypothetical protein LOC9847 [Homo sapiens]
Length = 1000
Score = 30.4 bits (67), Expect = 0.55
Identities = 29/126 (23%), Positives = 56/126 (44%), Gaps = 20/126 (15%)
Query: 25 EKPEPTNQGQDSLKKRLQAKVKVIGVHSSLAGSILSALSALVGFILLSVNPAALNPASLQ 84
++PE + +++ +++ K +G H+ + S +++ V + S A LNP LQ
Sbjct: 383 DEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILSASGTAAVLNPRFLQ 442
Query: 85 ------C--KLDEKDIPTR----------LLLSYDYHSPYTMDCHRAKAS--LAGTLSLM 124
C + E+++PTR L + + H Y +C + K L T+ L
Sbjct: 443 DGTVEGCLEQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLP 502
Query: 125 LVSTVL 130
+TV+
Sbjct: 503 TDATVI 508
>gi|190194363 dihydropyrimidinase-like 4 [Homo sapiens]
Length = 572
Score = 28.1 bits (61), Expect = 2.8
Identities = 16/55 (29%), Positives = 29/55 (52%)
Query: 91 DIPTRLLLSYDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQ 145
D+ TRL + +P C KA+LAG +++L + +++L A QW++
Sbjct: 71 DVHTRLQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRE 125
>gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]
Length = 1363
Score = 28.1 bits (61), Expect = 2.8
Identities = 19/61 (31%), Positives = 33/61 (54%), Gaps = 2/61 (3%)
Query: 45 VKVIGVHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHS 104
V+++ + + G++LS + A VG I + V + NP S Q +DE P + L ++ S
Sbjct: 968 VRLLRISTIAEGTLLSVIRA-VGSICIGVAHTS-NPVSQQFVVDENAFPVLIQLLRNHPS 1025
Query: 105 P 105
P
Sbjct: 1026 P 1026
>gi|21218438 GATA zinc finger domain containing 2B [Homo sapiens]
Length = 593
Score = 27.7 bits (60), Expect = 3.6
Identities = 25/85 (29%), Positives = 38/85 (44%), Gaps = 7/85 (8%)
Query: 6 ISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVH----SSLAGS--IL 59
+ E ++ V N + +P P + GQ L K L ++ GV +L G I
Sbjct: 191 LQKENVVQKTPVVQNAASIVQPSPAHVGQQGLSK-LPSRPGAQGVEPQNLRTLQGHSVIR 249
Query: 60 SALSALVGFILLSVNPAALNPASLQ 84
SA + + +L+S A NPA LQ
Sbjct: 250 SATNTTLPHMLMSQRVIAPNPAQLQ 274
>gi|82659109 retinoblastoma-associated factor 600 [Homo sapiens]
Length = 5183
Score = 26.6 bits (57), Expect = 8.0
Identities = 9/28 (32%), Positives = 20/28 (71%)
Query: 12 IMLPSNVINFSQAEKPEPTNQGQDSLKK 39
IM P+N+++F++++ P+ +G D K+
Sbjct: 2582 IMRPNNLVHFTESKLPQMETEGMDEGKE 2609
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.130 0.363
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 4,966,681
Number of Sequences: 37866
Number of extensions: 178562
Number of successful extensions: 497
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 471
Number of HSP's gapped (non-prelim): 26
length of query: 147
length of database: 18,247,518
effective HSP length: 93
effective length of query: 54
effective length of database: 14,725,980
effective search space: 795202920
effective search space used: 795202920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 57 (26.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.