Search of human proteins with 209364523

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|209364523 alsin isoform 2 [Homo sapiens]
         (396 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|209364523 alsin isoform 2 [Homo sapiens]                           797   0.0  
gi|40316935 alsin isoform 1 [Homo sapiens]                            746   0.0  
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]             89   7e-18
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]             89   7e-18
gi|7657152 hect domain and RLD 3 [Homo sapiens]                        89   9e-18
gi|61563742 hect domain and RLD 6 [Homo sapiens]                       86   8e-17
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ...    82   6e-16
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]    79   7e-15
gi|126032348 hect domain and RLD 2 [Homo sapiens]                      78   1e-14
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo...    74   3e-13
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    74   3e-13
gi|110825982 hect domain and RLD 5 [Homo sapiens]                      73   5e-13
gi|4557445 regulator of chromosome condensation and BTB domain c...    72   9e-13
gi|30039692 NIMA-related kinase 8 [Homo sapiens]                       70   3e-12
gi|63054860 RCC1 domain containing 1 [Homo sapiens]                    64   2e-10
gi|63054858 RCC1 domain containing 1 [Homo sapiens]                    64   2e-10
gi|6912330 deafness locus associated putative guanine nucleotide...    59   1e-08
gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo s...    56   5e-08
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ...    56   6e-08
gi|222136641 NIMA-related kinase 9 [Homo sapiens]                      55   1e-07
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]     53   5e-07
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]      53   5e-07
gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo ...    53   5e-07
gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s...    52   7e-07
gi|114796646 regulator of chromosome condensation 1 isoform b [H...    52   9e-07
gi|114796644 regulator of chromosome condensation 1 isoform a [H...    52   9e-07
gi|4502801 regulator of chromosome condensation 1 isoform c [Hom...    52   9e-07
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]     52   9e-07
gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]     52   9e-07
gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]     52   9e-07

>gi|209364523 alsin isoform 2 [Homo sapiens]
          Length = 396

 Score =  797 bits (2059), Expect = 0.0
 Identities = 396/396 (100%), Positives = 396/396 (100%)

Query: 1   MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG 60
           MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG
Sbjct: 1   MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG 60

Query: 61  EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA 120
           EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA
Sbjct: 61  EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA 120

Query: 121 GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL 180
           GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL
Sbjct: 121 GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL 180

Query: 181 GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI 240
           GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI
Sbjct: 181 GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI 240

Query: 241 TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS 300
           TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS
Sbjct: 241 TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS 300

Query: 301 VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED 360
           VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED
Sbjct: 301 VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED 360

Query: 361 SEHGEKPVPSQVPAQFYKIKVCLELNCMGFSLETLK 396
           SEHGEKPVPSQVPAQFYKIKVCLELNCMGFSLETLK
Sbjct: 361 SEHGEKPVPSQVPAQFYKIKVCLELNCMGFSLETLK 396


>gi|40316935 alsin isoform 1 [Homo sapiens]
          Length = 1657

 Score =  746 bits (1927), Expect = 0.0
 Identities = 371/371 (100%), Positives = 371/371 (100%)

Query: 1   MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG 60
           MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG
Sbjct: 1   MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG 60

Query: 61  EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA 120
           EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA
Sbjct: 61  EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA 120

Query: 121 GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL 180
           GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL
Sbjct: 121 GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL 180

Query: 181 GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI 240
           GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI
Sbjct: 181 GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI 240

Query: 241 TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS 300
           TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS
Sbjct: 241 TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS 300

Query: 301 VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED 360
           VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED
Sbjct: 301 VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED 360

Query: 361 SEHGEKPVPSQ 371
           SEHGEKPVPSQ
Sbjct: 361 SEHGEKPVPSQ 371



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 51/209 (24%), Positives = 84/209 (40%), Gaps = 15/209 (7%)

Query: 24  QAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPI 83
           QAGS  I PE L     + V Q ++  K    L +  E  + G     S P  +   SP 
Sbjct: 435 QAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSRRLSLPGLLSQVSPR 494

Query: 84  LENALVGQYVITVATGSFHSGAVTD-----NGVAYMWGENSAGQCAVANQQYVPEPNPVS 138
           L          TV     +SG             + WG+   GQ  + +   +P   P+ 
Sbjct: 495 LLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQ--LGHGDVLPRLQPLC 552

Query: 139 IADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHL 198
           +   +        ++ L  G  H+LAL+   ++++WG+     L  + FP T P+  +  
Sbjct: 553 VKCLDGK-----EVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTVPRLAKIS 607

Query: 199 AGRVVLQVACGAFHSLALVQCLPSQDLKP 227
           +   V  +A G  +SL LV    ++D +P
Sbjct: 608 SENGVWSIAAGRDYSLFLVD---TEDFQP 633


>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
          Length = 1049

 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 63/191 (32%), Positives = 94/191 (49%), Gaps = 12/191 (6%)

Query: 30  ITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALV 89
           + P +   +  K V     G++H V + +DG VY+ G         E     P    AL 
Sbjct: 23  LEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALD 82

Query: 90  GQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCA-VANQQYVPEP-NPVSIADSEASPL 147
            Q ++ V+ G  H+ A+ D G  Y WG +S GQ   V +++ +  P N  S++D      
Sbjct: 83  AQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSD------ 136

Query: 148 LAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQ 205
             ++I+Q+ACG  H+LALS + E++ WG     QLGL T     T PQ ++ L G   +Q
Sbjct: 137 --IQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQ 194

Query: 206 VACGAFHSLAL 216
           VA G  HS  L
Sbjct: 195 VAAGGAHSFVL 205



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 59/193 (30%), Positives = 96/193 (49%), Gaps = 17/193 (8%)

Query: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPW-RSGPVEICP--SSPILENAL 88
           P  +       ++Q A G  H + L++  EV+ +G   + + G    C   +SP L  +L
Sbjct: 128 PRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSL 187

Query: 89  VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAV--ANQQYVPEPNPVSIADSEASP 146
           +G   + VA G  HS  +T +G  + WG N  GQ  +   N +YVP         +    
Sbjct: 188 LGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVP---------NLLKS 238

Query: 147 LLAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVL 204
           L + +I+ + CGE+HT AL+    ++ +G G   QLG  +T+  +  P+KV  L G +V 
Sbjct: 239 LRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEI-NPRKVFELMGSIVT 297

Query: 205 QVACGAFHSLALV 217
           ++ACG  H+ A V
Sbjct: 298 EIACGRQHTSAFV 310



 Score = 62.4 bits (150), Expect = 7e-10
 Identities = 50/197 (25%), Positives = 87/197 (44%), Gaps = 22/197 (11%)

Query: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGT-LPWRSGPV--EICPSSPILENAL 88
           PE++     + ++  + G  H + L + G+VY++G     + G V  E C   P    +L
Sbjct: 75  PEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSL 134

Query: 89  VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASP-- 146
               ++ VA G +HS A++     + WG+N  GQ  +                 + SP  
Sbjct: 135 SDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTD-----------CKKQTSPQL 183

Query: 147 ---LLAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGR 201
              LL +  +Q+A G  H+  L++S  I+ WG     QLGL         P  ++ L  +
Sbjct: 184 LKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-NDENDRYVPNLLKSLRSQ 242

Query: 202 VVLQVACGAFHSLALVQ 218
            ++ + CG  H+ AL +
Sbjct: 243 KIVYICCGEDHTAALTK 259


>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
          Length = 1057

 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 63/191 (32%), Positives = 94/191 (49%), Gaps = 12/191 (6%)

Query: 30  ITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALV 89
           + P +   +  K V     G++H V + +DG VY+ G         E     P    AL 
Sbjct: 23  LEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALD 82

Query: 90  GQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCA-VANQQYVPEP-NPVSIADSEASPL 147
            Q ++ V+ G  H+ A+ D G  Y WG +S GQ   V +++ +  P N  S++D      
Sbjct: 83  AQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSD------ 136

Query: 148 LAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQ 205
             ++I+Q+ACG  H+LALS + E++ WG     QLGL T     T PQ ++ L G   +Q
Sbjct: 137 --IQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQ 194

Query: 206 VACGAFHSLAL 216
           VA G  HS  L
Sbjct: 195 VAAGGAHSFVL 205



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 59/193 (30%), Positives = 96/193 (49%), Gaps = 17/193 (8%)

Query: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPW-RSGPVEICP--SSPILENAL 88
           P  +       ++Q A G  H + L++  EV+ +G   + + G    C   +SP L  +L
Sbjct: 128 PRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSL 187

Query: 89  VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAV--ANQQYVPEPNPVSIADSEASP 146
           +G   + VA G  HS  +T +G  + WG N  GQ  +   N +YVP         +    
Sbjct: 188 LGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVP---------NLLKS 238

Query: 147 LLAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVL 204
           L + +I+ + CGE+HT AL+    ++ +G G   QLG  +T+  +  P+KV  L G +V 
Sbjct: 239 LRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEI-NPRKVFELMGSIVT 297

Query: 205 QVACGAFHSLALV 217
           ++ACG  H+ A V
Sbjct: 298 EIACGRQHTSAFV 310



 Score = 62.4 bits (150), Expect = 7e-10
 Identities = 50/197 (25%), Positives = 87/197 (44%), Gaps = 22/197 (11%)

Query: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGT-LPWRSGPV--EICPSSPILENAL 88
           PE++     + ++  + G  H + L + G+VY++G     + G V  E C   P    +L
Sbjct: 75  PEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSL 134

Query: 89  VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASP-- 146
               ++ VA G +HS A++     + WG+N  GQ  +                 + SP  
Sbjct: 135 SDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTD-----------CKKQTSPQL 183

Query: 147 ---LLAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGR 201
              LL +  +Q+A G  H+  L++S  I+ WG     QLGL         P  ++ L  +
Sbjct: 184 LKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-NDENDRYVPNLLKSLRSQ 242

Query: 202 VVLQVACGAFHSLALVQ 218
            ++ + CG  H+ AL +
Sbjct: 243 KIVYICCGEDHTAALTK 259


>gi|7657152 hect domain and RLD 3 [Homo sapiens]
          Length = 1050

 Score = 88.6 bits (218), Expect = 9e-18
 Identities = 65/183 (35%), Positives = 86/183 (46%), Gaps = 18/183 (9%)

Query: 41  KTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGS 100
           ++V + A G  H V L EDGEVY+ G         E   + P    AL  Q++I VA G 
Sbjct: 34  RSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGALADQHIIHVACGE 93

Query: 101 FHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVR-----ILQL 155
            HS A++D G  + WG  S GQ  +           ++  DS A P L  +     ILQ+
Sbjct: 94  SHSLALSDRGQLFSWGAGSDGQLGL-----------MTTEDSVAVPRLIQKLNQQTILQV 142

Query: 156 ACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHS 213
           +CG  H LAL+   + + WG     QLGL         PQ+V  L G  + QVA G  HS
Sbjct: 143 SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHS 202

Query: 214 LAL 216
            AL
Sbjct: 203 FAL 205



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 66/218 (30%), Positives = 106/218 (48%), Gaps = 24/218 (11%)

Query: 16  ERGLVHIWQAGS-----------FPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYS 64
           +RG +  W AGS               P  +     +T+LQ + G  H + L  DG+ ++
Sbjct: 101 DRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFT 160

Query: 65  FG-TLPWRSGPVEICPS--SPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAG 121
           +G     + G  +  PS  SP    +L G  +  VA G  HS A++ +G  + WG N+AG
Sbjct: 161 WGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAG 220

Query: 122 QCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGC--Q 179
           Q  +++++    P  V +       L   +++ ++CGEEHT  L+ S  ++ +G G   Q
Sbjct: 221 QLGLSDEKDRESPCHVKL-------LRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQ 273

Query: 180 LGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALV 217
           LG  +    V  P++V  L G  V Q+ACG  H+LA V
Sbjct: 274 LGHDSMNDEV-NPRRVLELMGSEVTQIACGRQHTLAFV 310



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 51/194 (26%), Positives = 95/194 (48%), Gaps = 16/194 (8%)

Query: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSS-----PILEN 86
           PE++     + ++  A G  H + L++ G+++S+G      G + +  +      P L  
Sbjct: 75  PEQIGALADQHIIHVACGESHSLALSDRGQLFSWGA--GSDGQLGLMTTEDSVAVPRLIQ 132

Query: 87  ALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASP 146
            L  Q ++ V+ G++H  A+  +G  + WG+NS GQ  +  +++  + +P  +   E  P
Sbjct: 133 KLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGL-GKEFPSQASPQRVRSLEGIP 191

Query: 147 LLAVRILQLACGEEHTLALSISREIWAWG--TGCQLGLITTAFPVTKPQKVEHLAGRVVL 204
           L      Q+A G  H+ ALS+S  ++ WG     QLGL +       P  V+ L  + V+
Sbjct: 192 L-----AQVAAGGAHSFALSLSGAVFGWGMNNAGQLGL-SDEKDRESPCHVKLLRTQKVV 245

Query: 205 QVACGAFHSLALVQ 218
            ++CG  H+  L +
Sbjct: 246 YISCGEEHTAVLTK 259


>gi|61563742 hect domain and RLD 6 [Homo sapiens]
          Length = 1022

 Score = 85.5 bits (210), Expect = 8e-17
 Identities = 68/203 (33%), Positives = 90/203 (44%), Gaps = 14/203 (6%)

Query: 23  WQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLP----WRSGPVEIC 78
           W A S  +   R  G  G  +LQAA G +H +LL  +  V S G        R G     
Sbjct: 5   WGADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGE 64

Query: 79  PSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVS 138
              PI   AL    V  V+ G  HS AV   G  + WG  S GQ  +       E   +S
Sbjct: 65  LPEPI--QALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIG------EFKEIS 116

Query: 139 IADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVE 196
               +   L  ++I+Q++CG  H+LALS   ++++WG     QLGL         PQ+V 
Sbjct: 117 FTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVR 176

Query: 197 HLAGRVVLQVACGAFHSLALVQC 219
            L G  + QVA G  HS AL  C
Sbjct: 177 SLEGIPLAQVAAGGAHSFALSLC 199



 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 65/218 (29%), Positives = 109/218 (50%), Gaps = 24/218 (11%)

Query: 17  RGLVHIWQAGS-----------FPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSF 65
           +G V  W AGS              TP+++       ++Q + G  H + L++D +V+S+
Sbjct: 93  KGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSW 152

Query: 66  G-TLPWRSGPVEICPS--SPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQ 122
           G     + G  +  PS  SP    +L G  +  VA G  HS A++  G ++ WG NSAGQ
Sbjct: 153 GKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQ 212

Query: 123 CAVANQQYVPEPN-PVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWG--TGCQ 179
            A++ +    + N P+S+       L  + ++ ++CG+ HT  L+   +++ +G     Q
Sbjct: 213 LALSGRNVPVQSNKPLSV-----GALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQ 267

Query: 180 LGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALV 217
           LG   T      PQ VE + G +V Q+ CG++H+LA V
Sbjct: 268 LGYSPTP-EKRGPQLVERIDG-LVSQIDCGSYHTLAYV 303



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 40/130 (30%), Positives = 64/130 (49%), Gaps = 10/130 (7%)

Query: 93  VITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRI 152
           +I V+ G +HS A++ +   + WG+NS GQ  +  +++  + +P  +   E  PL     
Sbjct: 130 IIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLG-KEFPSQASPQRVRSLEGIPLA---- 184

Query: 153 LQLACGEEHTLALSISREIWAWGTGC--QLGLITTAFPV--TKPQKVEHLAGRVVLQVAC 208
            Q+A G  H+ ALS+    + WG+    QL L     PV   KP  V  L    V+ ++C
Sbjct: 185 -QVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISC 243

Query: 209 GAFHSLALVQ 218
           G  H+  L Q
Sbjct: 244 GDAHTAVLTQ 253


>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
           (POZ) domain containing protein 1 [Homo sapiens]
          Length = 531

 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 64/200 (32%), Positives = 97/200 (48%), Gaps = 27/200 (13%)

Query: 30  ITPERLPGWGGKTVLQAALGV-KHGVLLTEDGEVYSFG----------TLPWRSGPVEIC 78
           + P++L G  GK +   + G   H +L TEDG VY++G          T      PV++C
Sbjct: 63  LVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVC 122

Query: 79  PSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVS 138
                  N L+ Q V+ VA GS HS A+  +G  + WG N+ GQ    +    P P  V+
Sbjct: 123 T------NLLIKQ-VVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVT 175

Query: 139 IADSEASPLLAVRILQLACGEEHTLALSISREIWAWG--TGCQLGLITTAFPVTKPQKVE 196
                 + L   R++ +ACG+  ++A+  + E++ WG     QLGL      +T P +V 
Sbjct: 176 ------NCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLT-PVRVA 228

Query: 197 HLAGRVVLQVACGAFHSLAL 216
            L    V Q+ CG  H+LAL
Sbjct: 229 ALHSVCVNQIVCGYAHTLAL 248



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 42/135 (31%), Positives = 70/135 (51%), Gaps = 13/135 (9%)

Query: 88  LVGQYVITVATGSF-HSGAVTDNGVAYMWGENSAGQCA--VANQQYVPEPNPVSIADSEA 144
           L G+ + +++ GS  H    T++GV Y WG N   Q      NQ   P    V +  +  
Sbjct: 71  LCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAP----VQVCTN-- 124

Query: 145 SPLLAVRILQLACGEEHTLALSISREIWAWG-TGC-QLGLITTAFPVTKPQKVEHLAGRV 202
             LL  +++++ACG  H++AL+   E++AWG   C Q+G  +TA   T  +    L  + 
Sbjct: 125 --LLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKR 182

Query: 203 VLQVACGAFHSLALV 217
           V+ +ACG   S+A++
Sbjct: 183 VVGIACGQTSSMAVL 197



 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 36/141 (25%), Positives = 63/141 (44%), Gaps = 16/141 (11%)

Query: 41  KTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPS----SPILENALVGQYVITV 96
           K V+  A G    + + ++GEVY +G     +G + +  +    +P+   AL    V  +
Sbjct: 181 KRVVGIACGQTSSMAVLDNGEVYGWGYNG--NGQLGLGNNGNQLTPVRVAALHSVCVNQI 238

Query: 97  ATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQL- 155
             G  H+ A+TD G+ Y WG N+ GQ    N+  +  P  + +           R++++ 
Sbjct: 239 VCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKE--------RVVEIA 290

Query: 156 ACGEEHTLALSI-SREIWAWG 175
           AC   HT A       ++ WG
Sbjct: 291 ACHSAHTSAAKTQGGHVYMWG 311



 Score = 36.6 bits (83), Expect = 0.041
 Identities = 38/150 (25%), Positives = 65/150 (43%), Gaps = 17/150 (11%)

Query: 30  ITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVY-----SFGTLPWRSGPVEICPSSPIL 84
           +TP R+       V Q   G  H + LT++G +Y     ++G L   +    + P+  ++
Sbjct: 222 LTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMV 281

Query: 85  ENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSE- 143
           E   V +  I     +  S A T  G  YMWG+   GQ  +     +P     S  D   
Sbjct: 282 EKERVVE--IAACHSAHTSAAKTQGGHVYMWGQ-CRGQSVI-----LPHLTHFSCTDDVF 333

Query: 144 ---ASPLLAVRILQLACGEEHTLALSISRE 170
              A+P ++ R+L +   +  T+A S+ +E
Sbjct: 334 ACFATPAVSWRLLSVEHEDFLTVAESLKKE 363


>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
          Length = 4861

 Score = 79.0 bits (193), Expect = 7e-15
 Identities = 58/177 (32%), Positives = 82/177 (46%), Gaps = 15/177 (8%)

Query: 45  QAALGVKHGVLLTEDGE-VYSFG---TLPWRSGPVEICPSSPILENALVGQYVITVATGS 100
           + + G  H + L++DG  V+SFG         G         ++E AL G ++  V  GS
Sbjct: 565 EVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIE-ALQGMFIRKVCAGS 623

Query: 101 FHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEE 160
             S A+T  G  Y WG    G C            P  I +     L A RI+ ++ G+ 
Sbjct: 624 QSSLALTSTGQVYAWG---CGACLGCGSSEATALRPKLIEE-----LAATRIVDVSIGDS 675

Query: 161 HTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLA 215
           H LALS   E++AWG     Q G   +  P+TKP+KV  L G  + Q++ G  HSLA
Sbjct: 676 HCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLA 732



 Score = 72.0 bits (175), Expect = 9e-13
 Identities = 53/191 (27%), Positives = 96/191 (50%), Gaps = 15/191 (7%)

Query: 32   PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSS----PILENA 87
            P ++    G+ V+Q + G KH  ++T DG++++FG   +  G + +  +S    P    A
Sbjct: 4125 PRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY--GRLGLGNTSNKKLPERVTA 4182

Query: 88   LVGQYVITVATGSFHSGAVT-DNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASP 146
            L G  +  VA G  H+ AV+ D  + + +G+   G+  + N      P  + +       
Sbjct: 4183 LEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDV------- 4235

Query: 147  LLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLIT-TAFPVTKPQKVEHLAGRVVLQ 205
            L  + I ++ACG + ++AL+    ++ +G    +GL    A    +PQ++  LAG ++  
Sbjct: 4236 LCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIED 4295

Query: 206  VACGAFHSLAL 216
            VA GA H+LAL
Sbjct: 4296 VAVGAEHTLAL 4306



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 56/174 (32%), Positives = 86/174 (49%), Gaps = 17/174 (9%)

Query: 52   HGVLLTEDGEVYSFGTLPWRSGPVEICPSS----PILENALVGQYVITVATGSFHSGAVT 107
            H + LTE GEV+S+G   +  G +    S     P    AL G+ V+ ++ G  HS  VT
Sbjct: 4093 HSMALTESGEVFSWGDGDY--GKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVT 4150

Query: 108  DNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSI 167
             +G  + +G    G+  + N      P  V+  +         +I Q+ACG  HTLA+S 
Sbjct: 4151 SDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEG-------YQIGQVACGLNHTLAVSA 4203

Query: 168  SRE-IWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQ 218
                +WA+G G   +LGL  +    + PQK++ L G  + +VACG   S+AL +
Sbjct: 4204 DGSMVWAFGDGDYGKLGLGNSTAK-SSPQKIDVLCGIGIKKVACGTQFSVALTK 4256



 Score = 68.9 bits (167), Expect = 7e-12
 Identities = 65/227 (28%), Positives = 99/227 (43%), Gaps = 34/227 (14%)

Query: 52  HGVLLTEDGEVYS-----FGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAV 106
           H +  T +GEV+S     +G L   +   +  P   +++  L G+ V+ V+ G  HS AV
Sbjct: 469 HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPK--LIQGPLQGKVVVCVSAGYRHSAAV 526

Query: 107 TDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALS 166
           T++G  Y WGE   G+    +      P  V    +         + +++CG  HT+ALS
Sbjct: 527 TEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN---------VGEVSCGSSHTIALS 577

Query: 167 -ISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQ----- 218
              R +W++G G   +LG   T   V KP+ +E L G  + +V  G+  SLAL       
Sbjct: 578 KDGRTVWSFGGGDNGKLGHGDTN-RVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVY 636

Query: 219 ------CLPSQDLKPVPERCNQCSQLLITMTDKEDHVIISDSHCCPL 259
                 CL     +    R     +L  T   +   V I DSHC  L
Sbjct: 637 AWGCGACLGCGSSEATALRPKLIEELAAT---RIVDVSIGDSHCLAL 680



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 13/189 (6%)

Query: 32   PERLPGWGGKTVLQAALGVKHGVLLTEDGE-VYSFGTLPWRSGPV--EICPSSPILENAL 88
            PER+    G  + Q A G+ H + ++ DG  V++FG   +    +      SSP   + L
Sbjct: 4177 PERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVL 4236

Query: 89   VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLL 148
             G  +  VA G+  S A+T +G  Y +G++          +    P  + +       L 
Sbjct: 4237 CGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV-------LA 4289

Query: 149  AVRILQLACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQV 206
             V I  +A G EHTLAL+ + +++AWG+    QLGL  T   V +P  V  L G+ V Q+
Sbjct: 4290 GVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNH-VREPTLVTGLQGKNVRQI 4348

Query: 207  ACGAFHSLA 215
            + G  HS A
Sbjct: 4349 SAGRCHSAA 4357



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 49/183 (26%), Positives = 89/183 (48%), Gaps = 18/183 (9%)

Query: 40  GKTVLQAALGVKHGVLLTEDGEVYS-----FGTLPWRSGPVEICPSSPILENALVGQYVI 94
           GK V+  + G +H   +TEDGE+Y+     FG L          P+  + + + VG+   
Sbjct: 510 GKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTL-VKDISNVGE--- 565

Query: 95  TVATGSFHSGAVTDNG-VAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRIL 153
            V+ GS H+ A++ +G   + +G    G+    +   V +P  +         L  + I 
Sbjct: 566 -VSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEA-------LQGMFIR 617

Query: 154 QLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHS 213
           ++  G + +LAL+ + +++AWG G  LG  ++     +P+ +E LA   ++ V+ G  H 
Sbjct: 618 KVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHC 677

Query: 214 LAL 216
           LAL
Sbjct: 678 LAL 680



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 41/140 (29%), Positives = 64/140 (45%), Gaps = 17/140 (12%)

Query: 31   TPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGT-----LPWRSGPVEICPSS-PIL 84
            +P+++    G  + + A G +  V LT+DG VY+FG      LP         P   P+L
Sbjct: 4229 SPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVL 4288

Query: 85   ENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEA 144
               ++      VA G+ H+ A+  NG  Y WG NS GQ  + +  +V EP  V       
Sbjct: 4289 AGVIIED----VAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLV------- 4337

Query: 145  SPLLAVRILQLACGEEHTLA 164
            + L    + Q++ G  H+ A
Sbjct: 4338 TGLQGKNVRQISAGRCHSAA 4357



 Score = 55.5 bits (132), Expect = 8e-08
 Identities = 41/148 (27%), Positives = 64/148 (43%), Gaps = 12/148 (8%)

Query: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRS-GPVEICPSSPILENALVG 90
           P+ +    G  + +   G +  + LT  G+VY++G       G  E     P L   L  
Sbjct: 605 PKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAA 664

Query: 91  QYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQ-YVPEPNPVSIADSEASPLLA 149
             ++ V+ G  H  A++ +   Y WG NS GQC   N    + +P  VS  D        
Sbjct: 665 TRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLD-------G 717

Query: 150 VRILQLACGEEHTL---ALSISREIWAW 174
           + I Q++ G  H+L   AL   R++ AW
Sbjct: 718 IAIQQISAGTSHSLAWTALPRDRQVVAW 745


>gi|126032348 hect domain and RLD 2 [Homo sapiens]
          Length = 4834

 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 56/181 (30%), Positives = 85/181 (46%), Gaps = 12/181 (6%)

Query: 41   KTVLQAALGVKHGVLLTEDGEVYSFGTLPW-RSGPVEICPS-SPILENALVGQYVITVAT 98
            K +   A G  H   LT  GE+Y++G   + R G  +      P +   L+G  VI VA 
Sbjct: 3099 KRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVAC 3158

Query: 99   GSFHSG--AVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLA 156
            GS  +   A+TD G+ + WG+   G+      +    P  +   + +        + Q+ 
Sbjct: 3159 GSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG-------VCQIE 3211

Query: 157  CGEEHTLALSISREIWAWGTGCQLGL-ITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLA 215
            CG + +LAL+ S  +W WG G    L   +   V KPQ VE L G+ ++ VA GA H LA
Sbjct: 3212 CGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLA 3271

Query: 216  L 216
            +
Sbjct: 3272 V 3272



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 63/204 (30%), Positives = 97/204 (47%), Gaps = 21/204 (10%)

Query: 25   AGSFPITPERLPGWGGKTVLQAAL--GVKHGVLLTEDGEVYSFGTLPWRSGPV----EIC 78
            +G+ PI P ++       V + A+  G +H   LT DG+V+S+G      G +     + 
Sbjct: 3030 SGTVPI-PRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGE--GDDGKLGHFSRMN 3086

Query: 79   PSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVS 138
               P L  AL  + +  +A GS HS A+T +G  Y WG    G+    +     +P  V 
Sbjct: 3087 CDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVK 3146

Query: 139  IADSEASPLLAVRILQLACG--EEHTLALSISREIWAWGTGCQLGLITTAFP--VTKPQK 194
            +       LL  R++Q+ACG  +  TLAL+    +++WG G   G +          PQ 
Sbjct: 3147 V-------LLGHRVIQVACGSRDAQTLALTDEGLVFSWGDG-DFGKLGRGGSEGCNIPQN 3198

Query: 195  VEHLAGRVVLQVACGAFHSLALVQ 218
            +E L G+ V Q+ CGA  SLAL +
Sbjct: 3199 IERLNGQGVCQIECGAQFSLALTK 3222



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 55/176 (31%), Positives = 83/176 (47%), Gaps = 14/176 (7%)

Query: 49   GVKHGVLLTEDGEVYSFGTLP---WRSGPVEICPSSPILENALVGQYVITVATGSFHSGA 105
            G KH + L+ +GEVYS+G         G    C    ++E+ L G  V+ VA G  HS  
Sbjct: 4047 GGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIES-LRGIEVVDVAAGGAHSAC 4105

Query: 106  VTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLAC--GEEHTL 163
            VT  G  Y WG+   G+   ++ +   +P  V         L   R++ +AC  G+  TL
Sbjct: 4106 VTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLV-------EALQGHRVVDIACGSGDAQTL 4158

Query: 164  ALSISREIWAWGTGCQLGLITTAFPVTK-PQKVEHLAGRVVLQVACGAFHSLALVQ 218
             L+    +W+WG G    L        K P K++ L G  V++V CG+  S+AL +
Sbjct: 4159 CLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTK 4214



 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 54/177 (30%), Positives = 86/177 (48%), Gaps = 19/177 (10%)

Query: 43   VLQAALGVKHGVLLTEDGEVYSFGT-------LPWRSGPVEICPSSPILENALVGQYVIT 95
            V+Q A G K    +T +G+VY+ G        L   SG V I      L + +V +  + 
Sbjct: 2994 VVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKK--VA 3051

Query: 96   VATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQL 155
            V +G  H+ A+T +G  + WGE   G+    ++    +P  +    ++       RI  +
Sbjct: 3052 VHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTK-------RIRDI 3104

Query: 156  ACGEEHTLALSISREIWAWGTGCQLGLITTAFPVT--KPQKVEHLAGRVVLQVACGA 210
            ACG  H+ AL+ S E++ WG G + G +      T  KP+ V+ L G  V+QVACG+
Sbjct: 3105 ACGSSHSAALTSSGELYTWGLG-EYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGS 3160



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 58/212 (27%), Positives = 102/212 (48%), Gaps = 18/212 (8%)

Query: 18  GLVHIWQAGSFPITPERLPGWGGKTVLQAALGVK--HGVLLTEDGEVYSFGTLPW-RSGP 74
           G V+     S  + P+ + G   + +++ A      H + L   GEVYS+G     R G 
Sbjct: 470 GRVYTQAYNSDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGH 529

Query: 75  VEICP-SSPILENAL----VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQ 129
            +  P   P + +A      G++V+ +A GS +S A+T  G  Y WG  + G+    + +
Sbjct: 530 GDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSE 589

Query: 130 YVPEPNPVSIADSEASPLLAVRILQLAC--GEEHTLALSISREIWAWGTGCQLGLITTAF 187
              E  P+ +A      L  ++++ +AC  G+  TLA++ + ++W+WG G    L     
Sbjct: 590 --DEAIPMLVAG-----LKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGS 642

Query: 188 PVTK-PQKVEHLAGRVVLQVACGAFHSLALVQ 218
              K P+ +E L    V++V CG+  S+AL +
Sbjct: 643 DGCKTPKLIEKLQDLDVVKVRCGSQFSIALTK 674



 Score = 65.9 bits (159), Expect = 6e-11
 Identities = 57/183 (31%), Positives = 90/183 (49%), Gaps = 16/183 (8%)

Query: 40   GKTVLQAALGVKHG--VLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENALVGQYVI 94
            G  V+Q A G +    + LT++G V+S+G   +     G  E C     +E  L GQ V 
Sbjct: 3150 GHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIER-LNGQGVC 3208

Query: 95   TVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQ 154
             +  G+  S A+T +GV + WG+    +    +  +V +P  V         L   +I+ 
Sbjct: 3209 QIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVE-------GLRGKKIVH 3261

Query: 155  LACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFH 212
            +A G  H LA++ S +++AWG     Q G  TT     KP  V+ L G+ + +VACG+ H
Sbjct: 3262 VAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVN-RKPTLVQGLEGQKITRVACGSSH 3320

Query: 213  SLA 215
            S+A
Sbjct: 3321 SVA 3323



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 60/221 (27%), Positives = 98/221 (44%), Gaps = 19/221 (8%)

Query: 30   ITPERLPGWGGKTVLQAALGVKHG--VLLTEDGEVYSFGTLPWRS---GPVEICPSSPIL 84
            + P+ +    G  V+  A G      + LT+D  V+S+G   +     G  + C   P+ 
Sbjct: 4132 LKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGC-KVPMK 4190

Query: 85   ENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEA 144
             ++L G  V+ V  GS  S A+T +G  Y WG+    +    +  +V  P  V       
Sbjct: 4191 IDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQ------ 4244

Query: 145  SPLLAVRILQLACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRV 202
              L   +++ +A G  H +  +   E++ WG     QLG  TT   + +P+ V  L G+ 
Sbjct: 4245 -GLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTN-AIQRPRLVAALQGKK 4302

Query: 203  VLQVACGAFHSLALVQCLPSQDLK---PVPERCNQCSQLLI 240
            V +VACG+ H+LA     P+   K    VP   N   ++ I
Sbjct: 4303 VNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYNHLQEIPI 4343



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 48/164 (29%), Positives = 73/164 (44%), Gaps = 25/164 (15%)

Query: 16   ERGLVHIWQAGSF-------------PITPERLPGWGGKTVLQAALGVKHGVLLTEDGEV 62
            + GLV  W  G F             P   ERL G G   V Q   G +  + LT+ G V
Sbjct: 3170 DEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG---VCQIECGAQFSLALTKSGVV 3226

Query: 63   YSFGTLPW-RSGP-VEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA 120
            +++G   + R G   ++    P +   L G+ ++ VA G+ H  AVTD+G  Y WG+N  
Sbjct: 3227 WTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDH 3286

Query: 121  GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLA 164
            GQ          +P  V   + +       +I ++ACG  H++A
Sbjct: 3287 GQQGNGTTTVNRKPTLVQGLEGQ-------KITRVACGSSHSVA 3323



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 47/165 (28%), Positives = 73/165 (44%), Gaps = 12/165 (7%)

Query: 31  TPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLP-WRSGP-VEICPSSPILENAL 88
           TP+ +       V++   G +  + LT+DG+VYS+G     R G   E     P L   L
Sbjct: 647 TPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGL 706

Query: 89  VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLL 148
            G+ VI VA GS H  A+T++   + WG N   QC   +   V +P P ++   +     
Sbjct: 707 QGKKVIDVAAGSTHCLALTEDSEVHSWGSND--QCQHFDTLRVTKPEPAALPGLDTK--- 761

Query: 149 AVRILQLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQ 193
              I+ +ACG   + A S   E   W  G ++  +     +T  Q
Sbjct: 762 --HIVGIACGPAQSFAWSSCSE---WSIGLRVPFVVDICSMTFEQ 801



 Score = 37.0 bits (84), Expect = 0.031
 Identities = 33/112 (29%), Positives = 50/112 (44%), Gaps = 12/112 (10%)

Query: 109  NGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSIS 168
            +G  Y WG N  GQ        V  P P          L  +R +QL  GE+   A++  
Sbjct: 3951 SGTIYGWGHNHRGQLGGIEGAKVKVPTP-------CEALATLRPVQLIGGEQTLFAVTAD 4003

Query: 169  REIWA--WGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVA--CGAFHSLAL 216
             +++A  +G G +LG+  T   V+ P  +E +    + +VA   G  H LAL
Sbjct: 4004 GKLYATGYGAGGRLGIGGTE-SVSTPTLLESIQHVFIKKVAVNSGGKHCLAL 4054


>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
           sapiens]
          Length = 815

 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 44/173 (25%), Positives = 88/173 (50%), Gaps = 9/173 (5%)

Query: 43  VLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFH 102
           + Q + G      LTEDG ++ +G        ++   +  + +   +G+ V  ++ G +H
Sbjct: 142 IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYH 201

Query: 103 SGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHT 162
           S  VT +G  Y++GE   G+  + NQ       P  +++      +  +++Q+ACG EHT
Sbjct: 202 SAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE------IPEKVIQVACGGEHT 255

Query: 163 LALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHS 213
           + L+    ++ +G G   QLGL T  F  ++P+ +E++  + +  ++CG  H+
Sbjct: 256 VVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHT 307



 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 46/170 (27%), Positives = 73/170 (42%), Gaps = 25/170 (14%)

Query: 55  LLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYM 114
           L+ + G V++FG    +S   E  P     +N +     + ++ G  HS  VT N   YM
Sbjct: 7   LMPDSGAVFTFG----KSKFAENNPGKFWFKNDVP----VHLSCGDEHSAVVTGNNKLYM 58

Query: 115 WGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAW 174
           +G N+ GQ  + ++  + +P  V     E       ++   ACG  HTL  +    ++A 
Sbjct: 59  FGSNNWGQLGLGSKSAISKPTCVKALKPE-------KVKLAACGRNHTLVSTEGGNVYAT 111

Query: 175 G--TGCQLGLITT----AFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQ 218
           G     QLGL  T     F V      EH     + Q++ G+  S AL +
Sbjct: 112 GGNNEGQLGLGDTEERNTFHVISFFTSEH----KIKQLSAGSNTSAALTE 157



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 53/190 (27%), Positives = 78/190 (41%), Gaps = 35/190 (18%)

Query: 40  GKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQY------- 92
           GK V   + G  H   +T DGE+Y FG     +G +        L N L+G +       
Sbjct: 189 GKPVSWISCGYYHSAFVTTDGELYVFGEP--ENGKLG-------LPNQLLGNHRTPQLVS 239

Query: 93  -----VITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQY-VPEPNPV-SIADSEAS 145
                VI VA G  H+  +T+N V Y +G    GQ  +    +   EP  + +I D   S
Sbjct: 240 EIPEKVIQVACGGEHTVVLTENAV-YTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTIS 298

Query: 146 PLLAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFP-VTKPQKVEHLAGRV 202
                    ++CGE HT  ++    ++ +G G   +LGL    F     P    +    +
Sbjct: 299 --------YISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFI 350

Query: 203 VLQVACGAFH 212
           V  VACG  H
Sbjct: 351 VKLVACGGCH 360


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 44/173 (25%), Positives = 88/173 (50%), Gaps = 9/173 (5%)

Query: 43  VLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFH 102
           + Q + G      LTEDG ++ +G        ++   +  + +   +G+ V  ++ G +H
Sbjct: 142 IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYH 201

Query: 103 SGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHT 162
           S  VT +G  Y++GE   G+  + NQ       P  +++      +  +++Q+ACG EHT
Sbjct: 202 SAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE------IPEKVIQVACGGEHT 255

Query: 163 LALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHS 213
           + L+    ++ +G G   QLGL T  F  ++P+ +E++  + +  ++CG  H+
Sbjct: 256 VVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHT 307



 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 46/170 (27%), Positives = 73/170 (42%), Gaps = 25/170 (14%)

Query: 55  LLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYM 114
           L+ + G V++FG    +S   E  P     +N +     + ++ G  HS  VT N   YM
Sbjct: 7   LMPDSGAVFTFG----KSKFAENNPGKFWFKNDVP----VHLSCGDEHSAVVTGNNKLYM 58

Query: 115 WGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAW 174
           +G N+ GQ  + ++  + +P  V     E       ++   ACG  HTL  +    ++A 
Sbjct: 59  FGSNNWGQLGLGSKSAISKPTCVKALKPE-------KVKLAACGRNHTLVSTEGGNVYAT 111

Query: 175 G--TGCQLGLITT----AFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQ 218
           G     QLGL  T     F V      EH     + Q++ G+  S AL +
Sbjct: 112 GGNNEGQLGLGDTEERNTFHVISFFTSEH----KIKQLSAGSNTSAALTE 157



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 53/190 (27%), Positives = 78/190 (41%), Gaps = 35/190 (18%)

Query: 40  GKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQY------- 92
           GK V   + G  H   +T DGE+Y FG     +G +        L N L+G +       
Sbjct: 189 GKPVSWISCGYYHSAFVTTDGELYVFGEP--ENGKLG-------LPNQLLGNHRTPQLVS 239

Query: 93  -----VITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQY-VPEPNPV-SIADSEAS 145
                VI VA G  H+  +T+N V Y +G    GQ  +    +   EP  + +I D   S
Sbjct: 240 EIPEKVIQVACGGEHTVVLTENAV-YTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTIS 298

Query: 146 PLLAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFP-VTKPQKVEHLAGRV 202
                    ++CGE HT  ++    ++ +G G   +LGL    F     P    +    +
Sbjct: 299 --------YISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFI 350

Query: 203 VLQVACGAFH 212
           V  VACG  H
Sbjct: 351 VKLVACGGCH 360


>gi|110825982 hect domain and RLD 5 [Homo sapiens]
          Length = 1024

 Score = 72.8 bits (177), Expect = 5e-13
 Identities = 53/185 (28%), Positives = 94/185 (50%), Gaps = 13/185 (7%)

Query: 41  KTVLQAALGVKHGVLLTEDGEVYSFG-TLPWRSGPVEICPSS--PILENALVGQYVITVA 97
           K ++Q   G  H + L++ GE++++G  L  + G     PS+  P +   L G  +  ++
Sbjct: 138 KKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQIS 197

Query: 98  TGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLAC 157
            G  HS A++ +G  Y WG+N  GQ  + + +   +P+ +   D++       ++  +AC
Sbjct: 198 AGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQ-------KVEFVAC 250

Query: 158 GEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLA 215
           G  H+  L+    ++ +G G   QLG  +T   + +P  V  L G  V Q+ACG +H+LA
Sbjct: 251 GGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNEL-RPCLVAELVGYRVTQIACGRWHTLA 309

Query: 216 LVQCL 220
            V  L
Sbjct: 310 YVSDL 314



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 51/172 (29%), Positives = 80/172 (46%), Gaps = 18/172 (10%)

Query: 49  GVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTD 108
           G +H ++L+ DG+ + +     +             E+ L  + +I +  G +HS A++ 
Sbjct: 105 GAEHMLILSSDGKPFEYDNYSMKHLR---------FESILQEKKIIQITCGDYHSLALSK 155

Query: 109 NGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSIS 168
            G  + WG+N  GQ  V  +       P +        L  V + Q++ GE H++ALS+S
Sbjct: 156 GGELFAWGQNLHGQLGVGRK------FPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMS 209

Query: 169 REIWAWGTG-C-QLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQ 218
             I++WG   C QLGL  T      P  +E L  + V  VACG  HS  L Q
Sbjct: 210 GNIYSWGKNECGQLGLGHTE-SKDDPSLIEGLDNQKVEFVACGGSHSALLTQ 260



 Score = 55.5 bits (132), Expect = 8e-08
 Identities = 45/151 (29%), Positives = 71/151 (47%), Gaps = 12/151 (7%)

Query: 31  TPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENA 87
           TP+ +    G  + Q + G  H + L+  G +YS+G         G  E     P L   
Sbjct: 181 TPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTE-SKDDPSLIEG 239

Query: 88  LVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPL 147
           L  Q V  VA G  HS  +T +G+ + +G    GQ    + Q   E  P  +A+     L
Sbjct: 240 LDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQ--NELRPCLVAE-----L 292

Query: 148 LAVRILQLACGEEHTLA-LSISREIWAWGTG 177
           +  R+ Q+ACG  HTLA +S   +++++G+G
Sbjct: 293 VGYRVTQIACGRWHTLAYVSDLGKVFSFGSG 323



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 43/148 (29%), Positives = 65/148 (43%), Gaps = 12/148 (8%)

Query: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGT-----LPWRSGPVEICPSSPILEN 86
           P  + G   + V   A G  H  LLT+DG +++FG      L   S   E+    P L  
Sbjct: 234 PSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNEL---RPCLVA 290

Query: 87  ALVGQYVITVATGSFHSGA-VTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEAS 145
            LVG  V  +A G +H+ A V+D G  + +G    GQ      +    P PV ++ SE  
Sbjct: 291 ELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEEL 350

Query: 146 PL---LAVRILQLACGEEHTLALSISRE 170
            L    + + L +  G   ++ L I +E
Sbjct: 351 KLESHTSEKELIMIAGGNQSILLWIKKE 378


>gi|4557445 regulator of chromosome condensation and BTB domain
           containing protein 2 [Homo sapiens]
          Length = 551

 Score = 72.0 bits (175), Expect = 9e-13
 Identities = 60/193 (31%), Positives = 94/193 (48%), Gaps = 13/193 (6%)

Query: 30  ITPERLPGWGGKTVLQAALGV-KHGVLLTEDGEVYSFGTLPWR---SGPVEICPSSPILE 85
           I P RL    GK +   + G   H VL T +GEV+++G   +    +G          + 
Sbjct: 87  IEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIS 146

Query: 86  NALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEAS 145
             L  + VI VA GS+HS  +T +G  + WG N++GQ  V +   V +P P  +     +
Sbjct: 147 TNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQ--VGSGSTVNQPIPRRVTGCLQN 204

Query: 146 PLLAVRILQLACGEEHTLALSISREIWAWG--TGCQLGLITTAFPVTKPQKVEHLAGRVV 203
            +    ++ +ACG+   +A+  + E++ WG     QLGL  +    T P +V  L G  V
Sbjct: 205 KV----VVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPT-PCRVAALQGIRV 259

Query: 204 LQVACGAFHSLAL 216
            +VACG  H+L L
Sbjct: 260 QRVACGYAHTLVL 272



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 46/151 (30%), Positives = 66/151 (43%), Gaps = 17/151 (11%)

Query: 32  PERLPGW-GGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPS----SPILEN 86
           P R+ G    K V+  A G    + + + GEVY +G     +G + +  S    +P    
Sbjct: 195 PRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNG--NGQLGLGNSGNQPTPCRVA 252

Query: 87  ALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASP 146
           AL G  V  VA G  H+  +TD G  Y WG NS GQ    N+     P PV++       
Sbjct: 253 ALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKD---- 308

Query: 147 LLAVRILQL-ACGEEHTLALSI-SREIWAWG 175
               RI+++ AC   HT A       ++ WG
Sbjct: 309 ----RIIEIAACHSTHTSAAKTQGGHVYMWG 335



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 45/167 (26%), Positives = 74/167 (44%), Gaps = 18/167 (10%)

Query: 13  GSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVY-----SFGT 67
           G    G + +  +G+ P TP R+    G  V + A G  H ++LT++G+VY     S+G 
Sbjct: 230 GYNGNGQLGLGNSGNQP-TPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQ 288

Query: 68  LPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVAN 127
           L   +   +  P+   +E   + +  I     +  S A T  G  YMWG+   GQ  +  
Sbjct: 289 LGTGNKSNQSYPTPVTVEKDRIIE--IAACHSTHTSAAKTQGGHVYMWGQ-CRGQSVI-- 343

Query: 128 QQYVPEPNPVSIADSE----ASPLLAVRILQLACGEEHTLALSISRE 170
              +P     S  D      A+P +  R+L +   +  T+A S+ RE
Sbjct: 344 ---LPHLTHFSCTDDVFACFATPAVTWRLLSVEPDDHLTVAESLKRE 387


>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
          Length = 692

 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 68/226 (30%), Positives = 99/226 (43%), Gaps = 24/226 (10%)

Query: 20  VHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICP 79
           V+ W  G    TP RLP    + V+Q A G      +T  G +  +   P  +G   + P
Sbjct: 314 VYAWGGGLG--TPLRLPMLNTE-VVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLP 370

Query: 80  SS------PILENALVGQYVIT---VATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQY 130
            +        +   L GQ  +T   VA G F +  +TD G+   +G  S G     +   
Sbjct: 371 GAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTD 430

Query: 131 VPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFP 188
           + +P  V         LL   ++Q+ACG  H LALS  RE++AWG G   +LGL  T   
Sbjct: 431 ISQPTIVEA-------LLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGL-GTRES 482

Query: 189 VTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQ 234
            + PQ+V    G+   +V CG   S+ L   +P Q L     R N+
Sbjct: 483 HSCPQQVPMPPGQEAQRVVCGIDSSMILT--VPGQALACGSNRFNK 526



 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 49/214 (22%), Positives = 94/214 (43%), Gaps = 25/214 (11%)

Query: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVY---------------SFGTLPWRSGPVE 76
           P+++P   G+   +   G+   ++LT  G+                 S G  P     VE
Sbjct: 486 PQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVE 545

Query: 77  ICPSSPILENALVGQY-VITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPN 135
              S  +L +A + Q  ++++  G+ HS AVT +G  Y +G N  GQ     ++      
Sbjct: 546 EALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRG----- 600

Query: 136 PVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQ 193
             S A  +   L  +++  +ACG+  T+A+    E+++WG G   +LG       + +P 
Sbjct: 601 --SRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPV 658

Query: 194 KVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKP 227
           +++      V  V+C   ++L  V+ +  + + P
Sbjct: 659 QLDETHPYTVTSVSCCHGNTLLAVRSVTDEPVPP 692


>gi|63054860 RCC1 domain containing 1 [Homo sapiens]
          Length = 376

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 55/207 (26%), Positives = 90/207 (43%), Gaps = 40/207 (19%)

Query: 45  QAALGVKHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENALVGQYVITVATGSF 101
           Q  LG +H +LL   G+V+S+G         G +E     P L  AL G  +  VA G +
Sbjct: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLE-AELEPRLLEALQGLVMAEVAAGGW 220

Query: 102 HSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVS------------------IADSE 143
           HS  V++ G  Y+WG N +GQ A+  +    +   V+                    D  
Sbjct: 221 HSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGA 280

Query: 144 ASPLLAVR-------------ILQLACGEEHTLALSISREI--WAWGTGCQLGLITTAFP 188
            +P +AV+              ++ +CG  HT  ++ + E+  W WG   QLG   T   
Sbjct: 281 PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTT-S 339

Query: 189 VTKPQKVEHLAGR--VVLQVACGAFHS 213
           + +P++VE+   +   V  V CG +++
Sbjct: 340 LDRPRRVEYFVDKQLQVKAVTCGPWNT 366



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 25/69 (36%), Positives = 40/69 (57%), Gaps = 3/69 (4%)

Query: 150 VRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQVA 207
           +R  QL  G EH L L  + ++++WG G   QLG  T    + +P+ +E L G V+ +VA
Sbjct: 158 LRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEL-EPRLLEALQGLVMAEVA 216

Query: 208 CGAFHSLAL 216
            G +HS+ +
Sbjct: 217 AGGWHSVCV 225


>gi|63054858 RCC1 domain containing 1 [Homo sapiens]
          Length = 376

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 55/207 (26%), Positives = 90/207 (43%), Gaps = 40/207 (19%)

Query: 45  QAALGVKHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENALVGQYVITVATGSF 101
           Q  LG +H +LL   G+V+S+G         G +E     P L  AL G  +  VA G +
Sbjct: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLE-AELEPRLLEALQGLVMAEVAAGGW 220

Query: 102 HSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVS------------------IADSE 143
           HS  V++ G  Y+WG N +GQ A+  +    +   V+                    D  
Sbjct: 221 HSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGA 280

Query: 144 ASPLLAVR-------------ILQLACGEEHTLALSISREI--WAWGTGCQLGLITTAFP 188
            +P +AV+              ++ +CG  HT  ++ + E+  W WG   QLG   T   
Sbjct: 281 PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTT-S 339

Query: 189 VTKPQKVEHLAGR--VVLQVACGAFHS 213
           + +P++VE+   +   V  V CG +++
Sbjct: 340 LDRPRRVEYFVDKQLQVKAVTCGPWNT 366



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 25/69 (36%), Positives = 40/69 (57%), Gaps = 3/69 (4%)

Query: 150 VRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQVA 207
           +R  QL  G EH L L  + ++++WG G   QLG  T    + +P+ +E L G V+ +VA
Sbjct: 158 LRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEL-EPRLLEALQGLVMAEVA 216

Query: 208 CGAFHSLAL 216
            G +HS+ +
Sbjct: 217 AGGWHSVCV 225


>gi|6912330 deafness locus associated putative guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 458

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 52/203 (25%), Positives = 84/203 (41%), Gaps = 36/203 (17%)

Query: 43  VLQAALGVKHGVLLTEDGEVYSFGT---------LPWRSGPVEICPSSPILENALVGQYV 93
           V+  A G++H V  T  G V+ +GT          P ++ P+      P     L     
Sbjct: 155 VVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKA 214

Query: 94  ITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRIL 153
           + V  GS HS ++TD G  Y+WG N  GQ A     ++P P  +     EA      ++ 
Sbjct: 215 MCVLAGSDHSASLTDAGEVYVWGSNKHGQLA-NEAAFLPVPQKI-----EAHCFQNEKVT 268

Query: 154 QLACGEEHTLALSISREIWAWGTG--CQLG-----------------LITTAFPVTKPQK 194
            +  G  H +A + + +++ WG     QLG                 L  +  P + P  
Sbjct: 269 AIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSS 328

Query: 195 VEHLAGRVVLQVACGAFHSLALV 217
              L G    +V+CG+ H+LA++
Sbjct: 329 PHCLTG--ATEVSCGSEHNLAII 349



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 57/205 (27%), Positives = 81/205 (39%), Gaps = 24/205 (11%)

Query: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWR--SGPVEICPSSPILE-NAL 88
           P R+ G      +    G  H   LT+ GEVY +G+      +      P    +E +  
Sbjct: 203 PSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANEAAFLPVPQKIEAHCF 262

Query: 89  VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQY-----------VPEPNPV 137
             + V  + +G  H  A T+ G  + WG    GQ     + Y           +P   P 
Sbjct: 263 QNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPP 322

Query: 138 SIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTG----CQLGLITTAFPVTKPQ 193
           +   S  SP       +++CG EH LA+ I    ++WG      C  G   T   V  P+
Sbjct: 323 NSMPS--SPHCLTGATEVSCGSEHNLAI-IGGVCYSWGWNEHGMCGDG---TEANVWAPK 376

Query: 194 KVEHLAGRVVLQVACGAFHSLALVQ 218
            V+ L     L V CGA HSLAL Q
Sbjct: 377 PVQALLSSSGLLVGCGAGHSLALCQ 401



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 45/180 (25%), Positives = 71/180 (39%), Gaps = 34/180 (18%)

Query: 38  WGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVA 97
           WG  +  Q  LG K  VLL +                         L +    + V  + 
Sbjct: 20  WGANSYGQLGLGHKEDVLLPQQ------------------------LNDFCKPRSVRRIT 55

Query: 98  TGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLAC 157
            G  HS  VTD G  ++ G N  GQ  + + + +P   P          L    I Q+AC
Sbjct: 56  GGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTP-------CKSLFGCPIQQVAC 108

Query: 158 GEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLA 215
           G + T+ L+ + ++ + G+    QLG+         PQ +E L    V+ +A G  H++A
Sbjct: 109 GWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIE-LHKEKVVCIAAGLRHAVA 167



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 47/200 (23%), Positives = 80/200 (40%), Gaps = 32/200 (16%)

Query: 29  PITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILE--- 85
           P +  R+ G GG           H  ++T+ G+++  G    + G + +  +  I     
Sbjct: 48  PRSVRRITGGGG-----------HSAVVTDGGDLFVCGLN--KDGQLGLGHTEDIPYFTP 94

Query: 86  -NALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEA 144
             +L G  +  VA G   +  +T+NG     G NS GQ  V +        P      +A
Sbjct: 95  CKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPH-------GPRRCVVPQA 147

Query: 145 SPLLAVRILQLACGEEHTLALSISREIWAWGTG--------CQLGLITTAFPVTKPQKVE 196
             L   +++ +A G  H +A + S  ++ WGTG        C    +   F   +P +V 
Sbjct: 148 IELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVT 207

Query: 197 HLAGRVVLQVACGAFHSLAL 216
            L     + V  G+ HS +L
Sbjct: 208 GLENSKAMCVLAGSDHSASL 227


>gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo
           sapiens]
          Length = 1052

 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 41/130 (31%), Positives = 65/130 (50%), Gaps = 10/130 (7%)

Query: 88  LVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPL 147
           L GQ V  +  G+    A+T +GV + WG+    +    +  +V +P  V         L
Sbjct: 705 LNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVE-------GL 757

Query: 148 LAVRILQLACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQ 205
              +I+ +A G +H LA+  S +++AWG     Q G  TT     KP  V+ L G+ ++ 
Sbjct: 758 RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVN-RKPMLVQGLEGQKIMC 816

Query: 206 VACGAFHSLA 215
           VACG+ HS+A
Sbjct: 817 VACGSSHSVA 826



 Score = 55.5 bits (132), Expect = 8e-08
 Identities = 53/199 (26%), Positives = 81/199 (40%), Gaps = 30/199 (15%)

Query: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVG- 90
           P   PG G     +     KHG L        + G   W   PV +     I+++  VG 
Sbjct: 595 PADEPGPGAPAPQELGAAGKHGDLCEVSLTSSAQGEATWPH-PV-LFHFGEIIQDKSVGN 652

Query: 91  -QYVITVATGSFHSGAVTDN----------GVAYMWGENSAGQCAVANQQYVPEPNPVSI 139
            +Y+ T        G V+DN          G+ + WG+   G+      +    P  +  
Sbjct: 653 WEYIST--------GKVSDNYALLTKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIER 704

Query: 140 ADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGL-ITTAFPVTKPQKVEHL 198
            + +        + Q+ CG +  LAL+ S  +W WG G    L   +   V KPQ VE L
Sbjct: 705 LNGQG-------VCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGL 757

Query: 199 AGRVVLQVACGAFHSLALV 217
            G+ ++ VA GA H LA++
Sbjct: 758 RGKKIVHVAVGAQHCLAVM 776



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 49/165 (29%), Positives = 70/165 (42%), Gaps = 31/165 (18%)

Query: 18  GLVHIWQAGSF-------------PITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYS 64
           GLV  W  G F             P   ERL G G   V Q   G +  + LT+ G V++
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG---VCQIECGAQFLLALTKSGVVWT 731

Query: 65  FGT-----LPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENS 119
           +G      L  RS   ++    P +   L G+ ++ VA G+ H  AV D+G  Y WG+N 
Sbjct: 732 WGKGDYFRLGHRS---DVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDND 788

Query: 120 AGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLA 164
            GQ    N        P+ +   E   ++ V     ACG  H++A
Sbjct: 789 HGQ--QGNGTTTVNRKPMLVQGLEGQKIMCV-----ACGSSHSVA 826


>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
           sapiens]
          Length = 596

 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 41/130 (31%), Positives = 65/130 (50%), Gaps = 10/130 (7%)

Query: 88  LVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPL 147
           L GQ V  +  G+    A+T +GV + WG+    +    +  +V +P  V         L
Sbjct: 53  LNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVE-------GL 105

Query: 148 LAVRILQLACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQ 205
              +I+ +A G +H LA+  S +++AWG     Q G  TT     KP  V+ L G+ ++ 
Sbjct: 106 RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVN-RKPTLVQGLEGQKIMC 164

Query: 206 VACGAFHSLA 215
           VACG+ HS+A
Sbjct: 165 VACGSSHSVA 174



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 38/138 (27%), Positives = 64/138 (46%), Gaps = 15/138 (10%)

Query: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGT-----LPWRSGPVEICPSSPILEN 86
           P+ +    G+ V Q   G +  + LT+ G V+++G      L  RS   ++    P +  
Sbjct: 47  PQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRS---DVHVRKPQVVE 103

Query: 87  ALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASP 146
            L G+ ++ VA G+ H  AV D+G  Y WG+N  GQ          +P  V   + +   
Sbjct: 104 GLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ--- 160

Query: 147 LLAVRILQLACGEEHTLA 164
               +I+ +ACG  H++A
Sbjct: 161 ----KIMCVACGSSHSVA 174



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 31/108 (28%), Positives = 50/108 (46%), Gaps = 8/108 (7%)

Query: 111 VAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISRE 170
           + + WG+   G+      +    P  +   + +        + Q+ CG +  LAL+ S  
Sbjct: 24  LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG-------VCQIECGAQFLLALTKSGV 76

Query: 171 IWAWGTGCQLGL-ITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALV 217
           +W WG G    L   +   V KPQ VE L G+ ++ VA GA H LA++
Sbjct: 77  VWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVM 124


>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
          Length = 979

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 60/230 (26%), Positives = 105/230 (45%), Gaps = 23/230 (10%)

Query: 4   KKRSSTEAEG-----SKERGLVHIWQAGSFPITPERLPGW-GGKTVLQAALGVKHGVLLT 57
           + RSST  E      +     V++W  G    TP++L     G +  Q   G  H  ++T
Sbjct: 328 RPRSSTVTEAPIAVVTSRTSEVYVWGGGKS--TPQKLDVIKSGCSARQVCAGNTHFAVVT 385

Query: 58  EDGEVYSF-----GT-LPWRSGPVEICP-SSPILENALVGQYVITVATGSFHSGAVTDNG 110
            + E+Y++     GT L  + G  +      P     L G+ +  V+ G   +  VTD G
Sbjct: 386 VEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEG 445

Query: 111 VAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISRE 170
             Y +G +  G C   ++   PE     +   + +  L+  + Q++CG+ H + L+ ++E
Sbjct: 446 QLYAFGSDYYG-CMGVDKVAGPEV----LEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKE 500

Query: 171 IWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQ 218
           +++WG G   +LGL +     T PQKV+     +++ V CG   +  L Q
Sbjct: 501 VYSWGCGEYGRLGLDSEEDYYT-PQKVDVPKALIIVAVQCGCDGTFLLTQ 549



 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 39/162 (24%), Positives = 67/162 (41%), Gaps = 21/162 (12%)

Query: 31  TPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPI------- 83
           TP+++       ++    G     LLT+ G+V + G   +    +  C S  I       
Sbjct: 522 TPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHE 581

Query: 84  --------LENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPN 135
                   L   L    + T+A G  H+ A+ + G    +G N  GQ  V N +     N
Sbjct: 582 VPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGIN 641

Query: 136 PVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTG 177
            +        PL   ++++++CG+E T+A +    I+AWG G
Sbjct: 642 LLG------GPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNG 677



 Score = 30.8 bits (68), Expect = 2.2
 Identities = 22/85 (25%), Positives = 37/85 (43%), Gaps = 5/85 (5%)

Query: 83  ILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADS 142
           +L   L G+ VI V+ G   + A TD+   + WG    G+ A+   +    P+   I  S
Sbjct: 642 LLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTE---RPHGSDICTS 698

Query: 143 EASPLLAV--RILQLACGEEHTLAL 165
              P+      +  L+C   HT+ +
Sbjct: 699 WPRPIFGSLHHVPDLSCRGWHTILI 723


>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
          Length = 522

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 51/214 (23%), Positives = 93/214 (43%), Gaps = 45/214 (21%)

Query: 35  LPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPS------SPILENAL 88
           L G   +TV+  +    H +L+T +G+++S+G    R+   ++         +P L   L
Sbjct: 145 LAGVRVRTVVSGSCAA-HSLLITTEGKLWSWG----RNEKGQLGHGDTKRVEAPRLIEGL 199

Query: 89  VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQ-QYVPEPNPVSIADSEASPL 147
             + +++ A G  H+ A+T+ G  + +GEN  GQ  + NQ   VP P  +          
Sbjct: 200 SHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQP---- 255

Query: 148 LAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEH-------- 197
               I ++ACG E ++ +     ++++G     QLG  +    + + Q++E+        
Sbjct: 256 ----ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRR 311

Query: 198 ---------------LAGRVVLQVACGAFHSLAL 216
                          +   VV  VACGA H+L L
Sbjct: 312 VAIFIEKTKDGQILPVPNVVVRDVACGANHTLVL 345



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 46/168 (27%), Positives = 72/168 (42%), Gaps = 25/168 (14%)

Query: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRS----GPVEICPS-SPILEN 86
           P  + G   + ++ AA G  H + LTE G V++FG             +  PS + I+ N
Sbjct: 193 PRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN 252

Query: 87  ALVGQYVITVATGSFHSGAVTDNGVAYMWG--------ENSAGQCAVANQ--QYVPEPNP 136
              GQ +  +A G+  S  +   G  Y +G         NS G+     Q  +Y  E  P
Sbjct: 253 ---GQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVP 309

Query: 137 VSIA-------DSEASPLLAVRILQLACGEEHTLALSISREIWAWGTG 177
             +A       D +  P+  V +  +ACG  HTL L   + +++WG G
Sbjct: 310 RRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFG 357



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 25/76 (32%), Positives = 40/76 (52%), Gaps = 5/76 (6%)

Query: 147 LLAVRILQLACGE--EHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRV 202
           L  VR+  +  G    H+L ++   ++W+WG     QLG   T   V  P+ +E L+  V
Sbjct: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTK-RVEAPRLIEGLSHEV 203

Query: 203 VLQVACGAFHSLALVQ 218
           ++  ACG  H+LAL +
Sbjct: 204 IVSAACGRNHTLALTE 219



 Score = 32.0 bits (71), Expect = 1.0
 Identities = 49/200 (24%), Positives = 77/200 (38%), Gaps = 27/200 (13%)

Query: 43  VLQAALGVKHGVLLTEDGEVYS-----FGTLPWRSGPVEICPSSPILENALVGQYVITVA 97
           V   A G  H ++L     V+S     +G L       E+ P    L +   G+    + 
Sbjct: 332 VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFD-FPGRGASQIY 390

Query: 98  TGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLAC 157
            G   S AV++ G  + WG  +  +    +  Y     P ++ D     L   RI  LAC
Sbjct: 391 AGYTCSFAVSEVGGLFFWGATNTSR---ESTMY-----PKAVQD-----LCGWRIRSLAC 437

Query: 158 GEEHTLALSISREIWAWGTGCQLGLITTAF----PVTKPQKVEHLAGRVVLQVACGAFHS 213
           G+   +  +    I +WG     G +          T  Q+V+ L G    QVA G  HS
Sbjct: 438 GKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHS 496

Query: 214 LALVQC---LPSQDLKPVPE 230
           L + +       + +K +PE
Sbjct: 497 LVIARDESETEKEKIKKLPE 516


>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
          Length = 522

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 51/214 (23%), Positives = 93/214 (43%), Gaps = 45/214 (21%)

Query: 35  LPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPS------SPILENAL 88
           L G   +TV+  +    H +L+T +G+++S+G    R+   ++         +P L   L
Sbjct: 145 LAGVRVRTVVSGSCAA-HSLLITTEGKLWSWG----RNEKGQLGHGDTKRVEAPRLIEGL 199

Query: 89  VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQ-QYVPEPNPVSIADSEASPL 147
             + +++ A G  H+ A+T+ G  + +GEN  GQ  + NQ   VP P  +          
Sbjct: 200 SHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQP---- 255

Query: 148 LAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEH-------- 197
               I ++ACG E ++ +     ++++G     QLG  +    + + Q++E+        
Sbjct: 256 ----ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRR 311

Query: 198 ---------------LAGRVVLQVACGAFHSLAL 216
                          +   VV  VACGA H+L L
Sbjct: 312 VAIFIEKTKDGQILPVPNVVVRDVACGANHTLVL 345



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 46/168 (27%), Positives = 72/168 (42%), Gaps = 25/168 (14%)

Query: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRS----GPVEICPS-SPILEN 86
           P  + G   + ++ AA G  H + LTE G V++FG             +  PS + I+ N
Sbjct: 193 PRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN 252

Query: 87  ALVGQYVITVATGSFHSGAVTDNGVAYMWG--------ENSAGQCAVANQ--QYVPEPNP 136
              GQ +  +A G+  S  +   G  Y +G         NS G+     Q  +Y  E  P
Sbjct: 253 ---GQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVP 309

Query: 137 VSIA-------DSEASPLLAVRILQLACGEEHTLALSISREIWAWGTG 177
             +A       D +  P+  V +  +ACG  HTL L   + +++WG G
Sbjct: 310 RRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFG 357



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 25/76 (32%), Positives = 40/76 (52%), Gaps = 5/76 (6%)

Query: 147 LLAVRILQLACGE--EHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRV 202
           L  VR+  +  G    H+L ++   ++W+WG     QLG   T   V  P+ +E L+  V
Sbjct: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTK-RVEAPRLIEGLSHEV 203

Query: 203 VLQVACGAFHSLALVQ 218
           ++  ACG  H+LAL +
Sbjct: 204 IVSAACGRNHTLALTE 219



 Score = 32.0 bits (71), Expect = 1.0
 Identities = 49/200 (24%), Positives = 77/200 (38%), Gaps = 27/200 (13%)

Query: 43  VLQAALGVKHGVLLTEDGEVYS-----FGTLPWRSGPVEICPSSPILENALVGQYVITVA 97
           V   A G  H ++L     V+S     +G L       E+ P    L +   G+    + 
Sbjct: 332 VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFD-FPGRGASQIY 390

Query: 98  TGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLAC 157
            G   S AV++ G  + WG  +  +    +  Y     P ++ D     L   RI  LAC
Sbjct: 391 AGYTCSFAVSEVGGLFFWGATNTSR---ESTMY-----PKAVQD-----LCGWRIRSLAC 437

Query: 158 GEEHTLALSISREIWAWGTGCQLGLITTAF----PVTKPQKVEHLAGRVVLQVACGAFHS 213
           G+   +  +    I +WG     G +          T  Q+V+ L G    QVA G  HS
Sbjct: 438 GKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHS 496

Query: 214 LALVQC---LPSQDLKPVPE 230
           L + +       + +K +PE
Sbjct: 497 LVIARDESETEKEKIKKLPE 516


>gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo
           sapiens]
          Length = 464

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 45/175 (25%), Positives = 73/175 (41%), Gaps = 14/175 (8%)

Query: 43  VLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQ------YVITV 96
           VLQ + G  H ++LT+   V+S G   +     ++  +    E+  V +       V+ V
Sbjct: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQV 235

Query: 97  ATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLA 156
           A G  HS  +TD G  Y  G  + GQ  + +      P  +         L  V ++Q+A
Sbjct: 236 ACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKL------GGDLAGVNVIQVA 289

Query: 157 CGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQVACG 209
              +  LA+S    ++ WG     QL  +T +  V  P+ +       V Q ACG
Sbjct: 290 TYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACG 344



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 56/189 (29%), Positives = 77/189 (40%), Gaps = 26/189 (13%)

Query: 43  VLQAALGVKHGVLLTEDGEVYSFGTLPWRS------GPVEICPSSPILENALVGQYVITV 96
           V+Q A G  H + LT+ GEVYS G   W +      G   I  S   L   L G  VI V
Sbjct: 232 VVQVACGQDHSLFLTDKGEVYSCG---WGADGQTGLGHYNITSSPTKLGGDLAGVNVIQV 288

Query: 97  ATGSFHSGAVTDNGVAYMWGENSAGQCA-VANQQYVPEPNPVSIADSEASPLLAVRILQL 155
           AT      AV+ +G  + WG +   Q A V +   V  P  +  +          ++ Q 
Sbjct: 289 ATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSG-------VGKVRQA 341

Query: 156 ACGEEHTLALSISREIWAWGTGCQLG----LITTAFPVTKPQKV----EHLAGRVVLQVA 207
           ACG      L+    ++ WG G  LG    L+ +A P   P  +    E      V ++ 
Sbjct: 342 ACGGTGCAVLNGEGHVFVWGYGI-LGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIR 400

Query: 208 CGAFHSLAL 216
           CG  H  AL
Sbjct: 401 CGLSHFAAL 409



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 29/94 (30%), Positives = 47/94 (50%), Gaps = 10/94 (10%)

Query: 129 QYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTG----CQLGLIT 184
           +YV EP+PVS+           R+LQ++CG  H+L L+    +++ G      C   ++ 
Sbjct: 156 EYVLEPSPVSLPLDRPQE---TRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVE 212

Query: 185 TAF--PVTKPQKVEHLAGRVVLQVACGAFHSLAL 216
                   +  +++   G+VV QVACG  HSL L
Sbjct: 213 NEIYSESHRVHRMQDFDGQVV-QVACGQDHSLFL 245



 Score = 31.6 bits (70), Expect = 1.3
 Identities = 32/134 (23%), Positives = 55/134 (41%), Gaps = 17/134 (12%)

Query: 43  VLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSP-ILENALVGQ-------YVI 94
           V QAA G     +L  +G V+ +G      GP  +  + P ++   L G         V 
Sbjct: 338 VRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVS 397

Query: 95  TVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQ 154
            +  G  H  A+T+ G  ++WG+N  G   +   +    P  V++             + 
Sbjct: 398 RIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEP---------VD 448

Query: 155 LACGEEHTLALSIS 168
           +ACG +H + L+ S
Sbjct: 449 VACGVDHMVTLAKS 462


>gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo
           sapiens]
          Length = 1102

 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 40/130 (30%), Positives = 64/130 (49%), Gaps = 10/130 (7%)

Query: 88  LVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPL 147
           L GQ V  +  G+    A+T +GV + WG+    +    +  +V +   V         L
Sbjct: 755 LNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVE-------GL 807

Query: 148 LAVRILQLACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQ 205
              +I+ +A G +H LA+  S +++AWG     Q G  TT     KP  V+ L G+ ++ 
Sbjct: 808 RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVN-RKPMLVQGLEGQKIMC 866

Query: 206 VACGAFHSLA 215
           VACG+ HS+A
Sbjct: 867 VACGSSHSVA 876



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 52/199 (26%), Positives = 80/199 (40%), Gaps = 30/199 (15%)

Query: 32  PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVG- 90
           P   PG G     +     KHG L        + G   W   PV +     I+++  VG 
Sbjct: 645 PADEPGPGAPAPQELGAAGKHGDLCEVSLTSSAQGEATWPH-PV-LFHFGEIIQDKSVGN 702

Query: 91  -QYVITVATGSFHSGAVTDN----------GVAYMWGENSAGQCAVANQQYVPEPNPVSI 139
            +Y+ T        G V+DN          G+ + WG+   G+      +    P  +  
Sbjct: 703 WEYIST--------GKVSDNYALLTKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIER 754

Query: 140 ADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGL-ITTAFPVTKPQKVEHL 198
            + +        + Q+ CG +  LAL+ S  +W WG G    L   +   V K Q VE L
Sbjct: 755 LNGQG-------VCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGL 807

Query: 199 AGRVVLQVACGAFHSLALV 217
            G+ ++ VA GA H LA++
Sbjct: 808 RGKKIVHVAVGAQHCLAVM 826



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 48/165 (29%), Positives = 69/165 (41%), Gaps = 31/165 (18%)

Query: 18  GLVHIWQAGSF-------------PITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYS 64
           GLV  W  G F             P   ERL G G   V Q   G +  + LT+ G V++
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG---VCQIECGAQFLLALTKSGVVWT 781

Query: 65  FGT-----LPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENS 119
           +G      L  RS   ++      +   L G+ ++ VA G+ H  AV D+G  Y WG+N 
Sbjct: 782 WGKGDYFRLGHRS---DVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDND 838

Query: 120 AGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLA 164
            GQ    N        P+ +   E   ++ V     ACG  H++A
Sbjct: 839 HGQ--QGNGTTTVNRKPMLVQGLEGQKIMCV-----ACGSSHSVA 876


>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
           sapiens]
          Length = 438

 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 42/151 (27%), Positives = 71/151 (47%), Gaps = 14/151 (9%)

Query: 43  VLQAALGVKHGVLLTEDGEVYSFGTLP----WRSGPVEICPSSPILENALVGQYVITVAT 98
           V+QA  G  H V L++ G+VYSFG        R   VE   S  +     + + V+ V+ 
Sbjct: 86  VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVE--GSEMVPGKVELQEKVVQVSA 143

Query: 99  GSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACG 158
           G  H+ A+TD+G  ++WG        +     + EP   S+   +    L V ++++A G
Sbjct: 144 GDSHTAALTDDGRVFLWGSFRDNNGVIG----LLEPMKKSMVPVQVQ--LDVPVVKVASG 197

Query: 159 EEHTLALSISREIWAWGTG--CQLGLITTAF 187
            +H + L+   +++  G G   QLG +   F
Sbjct: 198 NDHLVMLTADGDLYTLGCGEQGQLGRVPELF 228



 Score = 36.2 bits (82), Expect = 0.053
 Identities = 42/181 (23%), Positives = 69/181 (38%), Gaps = 37/181 (20%)

Query: 56  LTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYV----------ITVATGSFHSGA 105
           ++ +G VY FG   +          +P  E+  + Q +          +  + G  H+  
Sbjct: 272 ISHEGHVYGFGLSNYHQ------LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 325

Query: 106 VTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVR---ILQLACGEEHT 162
           +   G AY  G    G+  +              A+ ++ P L  R   +  +ACG    
Sbjct: 326 MDSEGKAYSLGRAEYGRLGLGEG-----------AEEKSIPTLISRLPAVSSVACGASVG 374

Query: 163 LALSISREIWAWGTGCQLGLIT-----TAFPVTKPQKVEHLAGRVVLQVACGAFHSLALV 217
            A++    ++AWG G    L T        PV    K   L  RVVL V+ G  H++ LV
Sbjct: 375 YAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGK--QLENRVVLSVSSGGQHTVLLV 432

Query: 218 Q 218
           +
Sbjct: 433 K 433


>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
           sapiens]
          Length = 452

 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 42/151 (27%), Positives = 71/151 (47%), Gaps = 14/151 (9%)

Query: 43  VLQAALGVKHGVLLTEDGEVYSFGTLP----WRSGPVEICPSSPILENALVGQYVITVAT 98
           V+QA  G  H V L++ G+VYSFG        R   VE   S  +     + + V+ V+ 
Sbjct: 100 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVE--GSEMVPGKVELQEKVVQVSA 157

Query: 99  GSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACG 158
           G  H+ A+TD+G  ++WG        +     + EP   S+   +    L V ++++A G
Sbjct: 158 GDSHTAALTDDGRVFLWGSFRDNNGVIG----LLEPMKKSMVPVQVQ--LDVPVVKVASG 211

Query: 159 EEHTLALSISREIWAWGTG--CQLGLITTAF 187
            +H + L+   +++  G G   QLG +   F
Sbjct: 212 NDHLVMLTADGDLYTLGCGEQGQLGRVPELF 242



 Score = 36.2 bits (82), Expect = 0.053
 Identities = 42/181 (23%), Positives = 69/181 (38%), Gaps = 37/181 (20%)

Query: 56  LTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYV----------ITVATGSFHSGA 105
           ++ +G VY FG   +          +P  E+  + Q +          +  + G  H+  
Sbjct: 286 ISHEGHVYGFGLSNYHQ------LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 339

Query: 106 VTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVR---ILQLACGEEHT 162
           +   G AY  G    G+  +              A+ ++ P L  R   +  +ACG    
Sbjct: 340 MDSEGKAYSLGRAEYGRLGLGEG-----------AEEKSIPTLISRLPAVSSVACGASVG 388

Query: 163 LALSISREIWAWGTGCQLGLIT-----TAFPVTKPQKVEHLAGRVVLQVACGAFHSLALV 217
            A++    ++AWG G    L T        PV    K   L  RVVL V+ G  H++ LV
Sbjct: 389 YAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGK--QLENRVVLSVSSGGQHTVLLV 446

Query: 218 Q 218
           +
Sbjct: 447 K 447


>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
           sapiens]
          Length = 421

 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 42/151 (27%), Positives = 71/151 (47%), Gaps = 14/151 (9%)

Query: 43  VLQAALGVKHGVLLTEDGEVYSFGTLP----WRSGPVEICPSSPILENALVGQYVITVAT 98
           V+QA  G  H V L++ G+VYSFG        R   VE   S  +     + + V+ V+ 
Sbjct: 69  VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVE--GSEMVPGKVELQEKVVQVSA 126

Query: 99  GSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACG 158
           G  H+ A+TD+G  ++WG        +     + EP   S+   +    L V ++++A G
Sbjct: 127 GDSHTAALTDDGRVFLWGSFRDNNGVIG----LLEPMKKSMVPVQVQ--LDVPVVKVASG 180

Query: 159 EEHTLALSISREIWAWGTG--CQLGLITTAF 187
            +H + L+   +++  G G   QLG +   F
Sbjct: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELF 211



 Score = 36.2 bits (82), Expect = 0.053
 Identities = 42/181 (23%), Positives = 69/181 (38%), Gaps = 37/181 (20%)

Query: 56  LTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYV----------ITVATGSFHSGA 105
           ++ +G VY FG   +          +P  E+  + Q +          +  + G  H+  
Sbjct: 255 ISHEGHVYGFGLSNYHQ------LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308

Query: 106 VTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVR---ILQLACGEEHT 162
           +   G AY  G    G+  +              A+ ++ P L  R   +  +ACG    
Sbjct: 309 MDSEGKAYSLGRAEYGRLGLGEG-----------AEEKSIPTLISRLPAVSSVACGASVG 357

Query: 163 LALSISREIWAWGTGCQLGLIT-----TAFPVTKPQKVEHLAGRVVLQVACGAFHSLALV 217
            A++    ++AWG G    L T        PV    K   L  RVVL V+ G  H++ LV
Sbjct: 358 YAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGK--QLENRVVLSVSSGGQHTVLLV 415

Query: 218 Q 218
           +
Sbjct: 416 K 416


>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
          Length = 421

 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 42/151 (27%), Positives = 71/151 (47%), Gaps = 14/151 (9%)

Query: 43  VLQAALGVKHGVLLTEDGEVYSFGTLP----WRSGPVEICPSSPILENALVGQYVITVAT 98
           V+QA  G  H V L++ G+VYSFG        R   VE   S  +     + + V+ V+ 
Sbjct: 69  VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVE--GSEMVPGKVELQEKVVQVSA 126

Query: 99  GSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACG 158
           G  H+ A+TD+G  ++WG        +     + EP   S+   +    L V ++++A G
Sbjct: 127 GDSHTAALTDDGRVFLWGSFRDNNGVIG----LLEPMKKSMVPVQVQ--LDVPVVKVASG 180

Query: 159 EEHTLALSISREIWAWGTG--CQLGLITTAF 187
            +H + L+   +++  G G   QLG +   F
Sbjct: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELF 211



 Score = 36.2 bits (82), Expect = 0.053
 Identities = 42/181 (23%), Positives = 69/181 (38%), Gaps = 37/181 (20%)

Query: 56  LTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYV----------ITVATGSFHSGA 105
           ++ +G VY FG   +          +P  E+  + Q +          +  + G  H+  
Sbjct: 255 ISHEGHVYGFGLSNYHQ------LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308

Query: 106 VTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVR---ILQLACGEEHT 162
           +   G AY  G    G+  +              A+ ++ P L  R   +  +ACG    
Sbjct: 309 MDSEGKAYSLGRAEYGRLGLGEG-----------AEEKSIPTLISRLPAVSSVACGASVG 357

Query: 163 LALSISREIWAWGTGCQLGLIT-----TAFPVTKPQKVEHLAGRVVLQVACGAFHSLALV 217
            A++    ++AWG G    L T        PV    K   L  RVVL V+ G  H++ LV
Sbjct: 358 YAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGK--QLENRVVLSVSSGGQHTVLLV 415

Query: 218 Q 218
           +
Sbjct: 416 K 416


>gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]
          Length = 421

 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 42/151 (27%), Positives = 71/151 (47%), Gaps = 14/151 (9%)

Query: 43  VLQAALGVKHGVLLTEDGEVYSFGTLP----WRSGPVEICPSSPILENALVGQYVITVAT 98
           V+QA  G  H V L++ G+VYSFG        R   VE   S  +     + + V+ V+ 
Sbjct: 69  VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVE--GSEMVPGKVELQEKVVQVSA 126

Query: 99  GSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACG 158
           G  H+ A+TD+G  ++WG        +     + EP   S+   +    L V ++++A G
Sbjct: 127 GDSHTAALTDDGRVFLWGSFRDNNGVIG----LLEPMKKSMVPVQVQ--LDVPVVKVASG 180

Query: 159 EEHTLALSISREIWAWGTG--CQLGLITTAF 187
            +H + L+   +++  G G   QLG +   F
Sbjct: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELF 211



 Score = 36.2 bits (82), Expect = 0.053
 Identities = 42/181 (23%), Positives = 69/181 (38%), Gaps = 37/181 (20%)

Query: 56  LTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYV----------ITVATGSFHSGA 105
           ++ +G VY FG   +          +P  E+  + Q +          +  + G  H+  
Sbjct: 255 ISHEGHVYGFGLSNYHQ------LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308

Query: 106 VTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVR---ILQLACGEEHT 162
           +   G AY  G    G+  +              A+ ++ P L  R   +  +ACG    
Sbjct: 309 MDSEGKAYSLGRAEYGRLGLGEG-----------AEEKSIPTLISRLPAVSSVACGASVG 357

Query: 163 LALSISREIWAWGTGCQLGLIT-----TAFPVTKPQKVEHLAGRVVLQVACGAFHSLALV 217
            A++    ++AWG G    L T        PV    K   L  RVVL V+ G  H++ LV
Sbjct: 358 YAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGK--QLENRVVLSVSSGGQHTVLLV 415

Query: 218 Q 218
           +
Sbjct: 416 K 416


>gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]
          Length = 421

 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 42/151 (27%), Positives = 71/151 (47%), Gaps = 14/151 (9%)

Query: 43  VLQAALGVKHGVLLTEDGEVYSFGTLP----WRSGPVEICPSSPILENALVGQYVITVAT 98
           V+QA  G  H V L++ G+VYSFG        R   VE   S  +     + + V+ V+ 
Sbjct: 69  VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVE--GSEMVPGKVELQEKVVQVSA 126

Query: 99  GSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACG 158
           G  H+ A+TD+G  ++WG        +     + EP   S+   +    L V ++++A G
Sbjct: 127 GDSHTAALTDDGRVFLWGSFRDNNGVIG----LLEPMKKSMVPVQVQ--LDVPVVKVASG 180

Query: 159 EEHTLALSISREIWAWGTG--CQLGLITTAF 187
            +H + L+   +++  G G   QLG +   F
Sbjct: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELF 211



 Score = 36.2 bits (82), Expect = 0.053
 Identities = 42/181 (23%), Positives = 69/181 (38%), Gaps = 37/181 (20%)

Query: 56  LTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYV----------ITVATGSFHSGA 105
           ++ +G VY FG   +          +P  E+  + Q +          +  + G  H+  
Sbjct: 255 ISHEGHVYGFGLSNYHQ------LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308

Query: 106 VTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVR---ILQLACGEEHT 162
           +   G AY  G    G+  +              A+ ++ P L  R   +  +ACG    
Sbjct: 309 MDSEGKAYSLGRAEYGRLGLGEG-----------AEEKSIPTLISRLPAVSSVACGASVG 357

Query: 163 LALSISREIWAWGTGCQLGLIT-----TAFPVTKPQKVEHLAGRVVLQVACGAFHSLALV 217
            A++    ++AWG G    L T        PV    K   L  RVVL V+ G  H++ LV
Sbjct: 358 YAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGK--QLENRVVLSVSSGGQHTVLLV 415

Query: 218 Q 218
           +
Sbjct: 416 K 416


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.129    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,259,856
Number of Sequences: 37866
Number of extensions: 687390
Number of successful extensions: 2035
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 1565
Number of HSP's gapped (non-prelim): 238
length of query: 396
length of database: 18,247,518
effective HSP length: 104
effective length of query: 292
effective length of database: 14,309,454
effective search space: 4178360568
effective search space used: 4178360568
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.