Search of human proteins with 189491774

Search of human proteins with 189491774

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens]
         (732 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens]                 1463   0.0  
gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens]                  1458   0.0  
gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens]                 1255   0.0  
gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens]                 1098   0.0  
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...    64   7e-10
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...    64   7e-10
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...    64   7e-10
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...    64   7e-10
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]     62   2e-09
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]     62   2e-09
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...    59   1e-08
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    57   5e-08
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    57   5e-08
gi|194294525 intersectin 2 isoform 2 [Homo sapiens]                    57   5e-08
gi|11342676 thyroid hormone receptor interactor 10 [Homo sapiens]      56   1e-07
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof...    56   1e-07
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    55   2e-07
gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ...    55   3e-07
gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ...    54   5e-07
gi|109689723 abl interactor 2 [Homo sapiens]                           54   5e-07
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    54   5e-07
gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-lik...    53   9e-07
gi|21735415 centromere protein B [Homo sapiens]                        53   9e-07
gi|17975763 myelin transcription factor 1 [Homo sapiens]               53   9e-07
gi|55749544 SH3 multiple domains 1 [Homo sapiens]                      52   2e-06
gi|68348709 formin binding protein 1-like isoform 1 [Homo sapiens]     51   4e-06
gi|41581463 formin binding protein 1-like isoform 2 [Homo sapiens]     51   4e-06
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]       51   4e-06
gi|58761548 tau tubulin kinase 1 [Homo sapiens]                        51   4e-06
gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a...    51   4e-06

>gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens]
          Length = 732

 Score = 1463 bits (3787), Expect = 0.0
 Identities = 732/732 (100%), Positives = 732/732 (100%)

Query: 1   MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK 60
           MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK
Sbjct: 1   MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK 60

Query: 61  NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEE 120
           NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEE
Sbjct: 61  NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEE 120

Query: 121 SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILL 180
           SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILL
Sbjct: 121 SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILL 180

Query: 181 VIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEV 240
           VIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEV
Sbjct: 181 VIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEV 240

Query: 241 KQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDTNGSETGFRAWNVQS 300
           KQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDTNGSETGFRAWNVQS
Sbjct: 241 KQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDTNGSETGFRAWNVQS 300

Query: 301 RGRIFLVSKPVLQINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQL 360
           RGRIFLVSKPVLQINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQL
Sbjct: 301 RGRIFLVSKPVLQINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQL 360

Query: 361 AFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKVLSN 420
           AFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKVLSN
Sbjct: 361 AFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKVLSN 420

Query: 421 IHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNST 480
           IHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNST
Sbjct: 421 IHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNST 480

Query: 481 GERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQI 540
           GERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQI
Sbjct: 481 GERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQI 540

Query: 541 MTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRMSLQ 600
           MTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRMSLQ
Sbjct: 541 MTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRMSLQ 600

Query: 601 STDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDCV 660
           STDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDCV
Sbjct: 601 STDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDCV 660

Query: 661 LPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLSEQT 720
           LPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLSEQT
Sbjct: 661 LPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLSEQT 720

Query: 721 YDFLGEMRKNAV 732
           YDFLGEMRKNAV
Sbjct: 721 YDFLGEMRKNAV 732


>gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens]
          Length = 733

 Score = 1458 bits (3775), Expect = 0.0
 Identities = 732/733 (99%), Positives = 732/733 (99%), Gaps = 1/733 (0%)

Query: 1   MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK 60
           MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK
Sbjct: 1   MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK 60

Query: 61  NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEE 120
           NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEE
Sbjct: 61  NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEE 120

Query: 121 SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILL 180
           SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILL
Sbjct: 121 SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILL 180

Query: 181 VIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEV 240
           VIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEV
Sbjct: 181 VIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEV 240

Query: 241 KQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDTNGSETGFRAWNVQS 300
           KQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDTNGSETGFRAWNVQS
Sbjct: 241 KQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDTNGSETGFRAWNVQS 300

Query: 301 RGRIFLVSKPVLQ-INTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQ 359
           RGRIFLVSKPVLQ INTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQ
Sbjct: 301 RGRIFLVSKPVLQQINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQ 360

Query: 360 LAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKVLS 419
           LAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKVLS
Sbjct: 361 LAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKVLS 420

Query: 420 NIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNS 479
           NIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNS
Sbjct: 421 NIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNS 480

Query: 480 TGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQ 539
           TGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQ
Sbjct: 481 TGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQ 540

Query: 540 IMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRMSL 599
           IMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRMSL
Sbjct: 541 IMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRMSL 600

Query: 600 QSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDC 659
           QSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDC
Sbjct: 601 QSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDC 660

Query: 660 VLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLSEQ 719
           VLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLSEQ
Sbjct: 661 VLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLSEQ 720

Query: 720 TYDFLGEMRKNAV 732
           TYDFLGEMRKNAV
Sbjct: 721 TYDFLGEMRKNAV 733


>gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens]
          Length = 677

 Score = 1255 bits (3247), Expect = 0.0
 Identities = 651/735 (88%), Positives = 657/735 (89%), Gaps = 61/735 (8%)

Query: 1   MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK 60
           MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK
Sbjct: 1   MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK 60

Query: 61  NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEE 120
           NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEE
Sbjct: 61  NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEE 120

Query: 121 SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILL 180
           SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILL
Sbjct: 121 SESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILL 180

Query: 181 VIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEV 240
           VIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESS    EE  E   E  D    
Sbjct: 181 VIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESS----EEGSEEDVEAVD---- 232

Query: 241 KQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDTNGSETGFRA---WN 297
                                                      E  +G+E   R    W+
Sbjct: 233 -------------------------------------------ETADGAEVKQRTDPHWS 249

Query: 298 VQSRGRIFLVSKPVLQINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMP 357
              +     +S+   QINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMP
Sbjct: 250 AVQKA----ISE---QINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMP 302

Query: 358 SQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKV 417
           SQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKV
Sbjct: 303 SQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGNKV 362

Query: 418 LSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIR 477
           LSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIR
Sbjct: 363 LSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIR 422

Query: 478 NSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVF 537
           NSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVF
Sbjct: 423 NSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVF 482

Query: 538 YQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRM 597
           YQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRM
Sbjct: 483 YQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKDRM 542

Query: 598 SLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYH 657
           SLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYH
Sbjct: 543 SLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYH 602

Query: 658 DCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLS 717
           DCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLS
Sbjct: 603 DCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFDLS 662

Query: 718 EQTYDFLGEMRKNAV 732
           EQTYDFLGEMRKNAV
Sbjct: 663 EQTYDFLGEMRKNAV 677


>gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens]
          Length = 614

 Score = 1098 bits (2841), Expect = 0.0
 Identities = 584/737 (79%), Positives = 598/737 (81%), Gaps = 128/737 (17%)

Query: 1   MLARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENK 60
           MLARRQRDPLQALRRRNQELKQQVDSLLSESQ                   LK+A++ NK
Sbjct: 1   MLARRQRDPLQALRRRNQELKQQVDSLLSESQ-------------------LKEALEPNK 41

Query: 61  NALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITE-VGAPTEEEE 119
                                                       R++I + VGAPTEEEE
Sbjct: 42  --------------------------------------------RQHIYQRVGAPTEEEE 57

Query: 120 ESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEIL 179
           ESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEIL
Sbjct: 58  ESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEIL 117

Query: 180 LVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAE 239
           LVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEED            
Sbjct: 118 LVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEED------------ 165

Query: 240 VKQRTDPHWSAVQKAISEAGIFCLVNHVSFCYLIVLMRNRMETVEDT-NGSETGFRA--- 295
                                                   +E V++T +G+E   R    
Sbjct: 166 ----------------------------------------VEAVDETADGAEVKQRTDPH 185

Query: 296 WNVQSRGRIFLVSKPVLQINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPEL 355
           W+         V K + +INTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPEL
Sbjct: 186 WSA--------VQKAISEINTVDVLTTMGAIPAGFRPSTLSQLLEEGNQFRANYFLQPEL 237

Query: 356 MPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGN 415
           MPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGN
Sbjct: 238 MPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDGN 297

Query: 416 KVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISY 475
           KVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISY
Sbjct: 298 KVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISY 357

Query: 476 IRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGS 535
           IRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGS
Sbjct: 358 IRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGTPYEKGIEVDPSISRRAHGS 417

Query: 536 VFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKD 595
           VFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKD
Sbjct: 418 VFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLKD 477

Query: 596 RMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLV 655
           RMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLV
Sbjct: 478 RMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLV 537

Query: 656 YHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFD 715
           YHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFD
Sbjct: 538 YHDCVLPLLHSTRLPPFRWAEEETETARWKVITDFLKQNQENQGALQALLSPDGVHEPFD 597

Query: 716 LSEQTYDFLGEMRKNAV 732
           LSEQTYDFLGEMRKNAV
Sbjct: 598 LSEQTYDFLGEMRKNAV 614


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 74/284 (26%), Positives = 113/284 (39%), Gaps = 39/284 (13%)

Query: 3   ARRQRDPLQAL-RRRNQELK---QQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDE 58
           +RR+RD L+ L R+R +E K   QQ +    + + + A E  K +   +      + + E
Sbjct: 150 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 209

Query: 59  NKNALQKLSKADESAPVAN------------YNQRKEEEHTLLDKLTQQLQGLAVTISRE 106
           + +   K S    S P                 + K EE  LL  L         T S E
Sbjct: 210 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAE 269

Query: 107 NITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQ 166
           + +       EEEE E E+ E+ G   E++EEEEEE+EE E    S  EE     + +A+
Sbjct: 270 SSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAE 326

Query: 167 QVGDLTFKKGE-------ILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQES 219
           +V +    + E       +L+V E + D     +D+  +E        E   E  EG   
Sbjct: 327 EVSEEEMSEDEERENENHLLVVPESRFD-----RDSGESE--------EAEEEVGEGTPQ 373

Query: 220 SEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAISEAGIFCL 263
           S   +E D           E+KQ    +  A+Q   S     CL
Sbjct: 374 SSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCL 417


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 74/284 (26%), Positives = 113/284 (39%), Gaps = 39/284 (13%)

Query: 3   ARRQRDPLQAL-RRRNQELK---QQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDE 58
           +RR+RD L+ L R+R +E K   QQ +    + + + A E  K +   +      + + E
Sbjct: 127 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 186

Query: 59  NKNALQKLSKADESAPVAN------------YNQRKEEEHTLLDKLTQQLQGLAVTISRE 106
           + +   K S    S P                 + K EE  LL  L         T S E
Sbjct: 187 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAE 246

Query: 107 NITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQ 166
           + +       EEEE E E+ E+ G   E++EEEEEE+EE E    S  EE     + +A+
Sbjct: 247 SSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAE 303

Query: 167 QVGDLTFKKGE-------ILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQES 219
           +V +    + E       +L+V E + D     +D+  +E        E   E  EG   
Sbjct: 304 EVSEEEMSEDEERENENHLLVVPESRFD-----RDSGESE--------EAEEEVGEGTPQ 350

Query: 220 SEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAISEAGIFCL 263
           S   +E D           E+KQ    +  A+Q   S     CL
Sbjct: 351 SSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCL 394


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 74/284 (26%), Positives = 113/284 (39%), Gaps = 39/284 (13%)

Query: 3   ARRQRDPLQAL-RRRNQELK---QQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDE 58
           +RR+RD L+ L R+R +E K   QQ +    + + + A E  K +   +      + + E
Sbjct: 116 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 175

Query: 59  NKNALQKLSKADESAPVAN------------YNQRKEEEHTLLDKLTQQLQGLAVTISRE 106
           + +   K S    S P                 + K EE  LL  L         T S E
Sbjct: 176 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAE 235

Query: 107 NITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQ 166
           + +       EEEE E E+ E+ G   E++EEEEEE+EE E    S  EE     + +A+
Sbjct: 236 SSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAE 292

Query: 167 QVGDLTFKKGE-------ILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQES 219
           +V +    + E       +L+V E + D     +D+  +E        E   E  EG   
Sbjct: 293 EVSEEEMSEDEERENENHLLVVPESRFD-----RDSGESE--------EAEEEVGEGTPQ 339

Query: 220 SEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAISEAGIFCL 263
           S   +E D           E+KQ    +  A+Q   S     CL
Sbjct: 340 SSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCL 383


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 74/284 (26%), Positives = 113/284 (39%), Gaps = 39/284 (13%)

Query: 3   ARRQRDPLQAL-RRRNQELK---QQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDE 58
           +RR+RD L+ L R+R +E K   QQ +    + + + A E  K +   +      + + E
Sbjct: 161 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 220

Query: 59  NKNALQKLSKADESAPVAN------------YNQRKEEEHTLLDKLTQQLQGLAVTISRE 106
           + +   K S    S P                 + K EE  LL  L         T S E
Sbjct: 221 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAE 280

Query: 107 NITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQ 166
           + +       EEEE E E+ E+ G   E++EEEEEE+EE E    S  EE     + +A+
Sbjct: 281 SSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAE 337

Query: 167 QVGDLTFKKGE-------ILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQES 219
           +V +    + E       +L+V E + D     +D+  +E        E   E  EG   
Sbjct: 338 EVSEEEMSEDEERENENHLLVVPESRFD-----RDSGESE--------EAEEEVGEGTPQ 384

Query: 220 SEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAISEAGIFCL 263
           S   +E D           E+KQ    +  A+Q   S     CL
Sbjct: 385 SSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCL 428


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 74/284 (26%), Positives = 113/284 (39%), Gaps = 39/284 (13%)

Query: 3   ARRQRDPLQAL-RRRNQELK---QQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDE 58
           +RR+RD L+ L R+R +E K   QQ +    + + + A E  K +   +      + + E
Sbjct: 149 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 208

Query: 59  NKNALQKLSKADESAPVAN------------YNQRKEEEHTLLDKLTQQLQGLAVTISRE 106
           + +   K S    S P                 + K EE  LL  L         T S E
Sbjct: 209 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAE 268

Query: 107 NITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQ 166
           + +       EEEE E E+ E+ G   E++EEEEEE+EE E    S  EE     + +A+
Sbjct: 269 SSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAE 325

Query: 167 QVGDLTFKKGE-------ILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQES 219
           +V +    + E       +L+V E + D     +D+  +E        E   E  EG   
Sbjct: 326 EVSEEEMSEDEERENENHLLVVPESRFD-----RDSGESE--------EAEEEVGEGTPQ 372

Query: 220 SEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAISEAGIFCL 263
           S   +E D           E+KQ    +  A+Q   S     CL
Sbjct: 373 SSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCL 416


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 74/284 (26%), Positives = 113/284 (39%), Gaps = 39/284 (13%)

Query: 3   ARRQRDPLQAL-RRRNQELK---QQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDE 58
           +RR+RD L+ L R+R +E K   QQ +    + + + A E  K +   +      + + E
Sbjct: 159 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 218

Query: 59  NKNALQKLSKADESAPVAN------------YNQRKEEEHTLLDKLTQQLQGLAVTISRE 106
           + +   K S    S P                 + K EE  LL  L         T S E
Sbjct: 219 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAE 278

Query: 107 NITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQ 166
           + +       EEEE E E+ E+ G   E++EEEEEE+EE E    S  EE     + +A+
Sbjct: 279 SSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAE 335

Query: 167 QVGDLTFKKGE-------ILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQES 219
           +V +    + E       +L+V E + D     +D+  +E        E   E  EG   
Sbjct: 336 EVSEEEMSEDEERENENHLLVVPESRFD-----RDSGESE--------EAEEEVGEGTPQ 382

Query: 220 SEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAISEAGIFCL 263
           S   +E D           E+KQ    +  A+Q   S     CL
Sbjct: 383 SSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCL 426


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 67/282 (23%), Positives = 111/282 (39%), Gaps = 36/282 (12%)

Query: 2   LARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLK-QAIDENK 60
           L R + + L+  R R +++++Q      + + +   E  +++   +R +    + + E+ 
Sbjct: 161 LFRDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDY 220

Query: 61  NALQKLSKADESAPVAN------------YNQRKEEEHTLLDKLTQQLQGLAVTISRENI 108
           +   K S    S P                 + K EE  LL  L         T S E+ 
Sbjct: 221 SDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESS 280

Query: 109 TEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQV 168
           +       EEEE E E+ E+ G   E++EEEEEE+EE E    S  EE     + +A++V
Sbjct: 281 SAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE---ASEQSAEEV 337

Query: 169 GDLTFKKGE-------ILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSE 221
            +    + E       +L+V E + D     +D+  +E        E   E  EG   S 
Sbjct: 338 SEEEMSEDEERENENHLLVVPESRFD-----RDSGESE--------EAEEEVGEGTPQSS 384

Query: 222 EGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAISEAGIFCL 263
             +E D           E+KQ    +  A+Q   S     CL
Sbjct: 385 ALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCL 426


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 36/109 (33%), Positives = 53/109 (48%), Gaps = 6/109 (5%)

Query: 131  GEEEDAEEEEE----EKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKP 186
            G E   EE E       ++  S  +S GEEYIA+  +++ + GDLTF +GE +LV +K  
Sbjct: 929  GSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-- 986

Query: 187  DGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETA 235
            DG W         G+ P  Y++P  +E  G  S    S +  E    T+
Sbjct: 987  DGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTS 1035



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 56/227 (24%), Positives = 96/227 (42%), Gaps = 34/227 (14%)

Query: 2   LARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENKN 61
           L +R ++ L AL +       ++DS    +QLKE  E    Q +      L+Q     ++
Sbjct: 591 LCQRLKEQLDALEKETASKLSEMDSF--NNQLKELRETYNTQQL-----ALEQLYKIKRD 643

Query: 62  ALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEES 121
            L+++ +           Q+K+ E     K  Q          +EN+ +     EEEE+ 
Sbjct: 644 KLKEIERKR-----LELMQKKKLEDEAARKAKQ---------GKENLWKENLRKEEEEKQ 689

Query: 122 ESEDSEDSGGEEEDAEEEEEEK----------EENESHKWSTGEEYIAVGDFTAQQVGDL 171
           +    E +  + ++ E + EEK          EE +    S    Y A+  F A+   ++
Sbjct: 690 KRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEM 749

Query: 172 TFKKGEILLVIEKK-PDGWWIAKDAKGNEGLVPRTYLE--PYSEEEE 215
           +F  G+I+ V EK   +  W+    +GN G  P  Y+E  P SE E+
Sbjct: 750 SFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 796



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 1/63 (1%)

Query: 156  EYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEE 215
            + IA+ D+ A    +L+F KG+++ V+ K    WW   +  G  GL P  Y++  ++ + 
Sbjct: 1104 QVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWW-QGEINGVTGLFPSNYVKMTTDSDP 1162

Query: 216  GQE 218
             Q+
Sbjct: 1163 SQQ 1165



 Score = 33.9 bits (76), Expect = 0.55
 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 2/63 (3%)

Query: 159 AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQE 218
           A+  +TA++   L F K +I+ V+E++ + WW   +  G  G  P++Y++     E  +E
Sbjct: 878 ALCSWTAKKDNHLNFSKHDIITVLEQQ-ENWWFG-EVHGGRGWFPKSYVKIIPGSEVKRE 935

Query: 219 SSE 221
             E
Sbjct: 936 EPE 938



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 64/268 (23%), Positives = 106/268 (39%), Gaps = 30/268 (11%)

Query: 2   LARRQRDPLQALRRR---NQELKQQVDSLLSESQLK------EALEPNKRQHIYQRCIQL 52
           L R++R   + +RR+   NQ+ ++Q + +   S+ K      EAL   K Q I  R   +
Sbjct: 454 LERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALN-GKHQQISGRLQDV 512

Query: 53  KQAIDENKNALQKLSKAD--ESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISR---EN 107
           +      K  L+ L K    E   +    Q  +E    L  L  + Q L   I      N
Sbjct: 513 RLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSN 572

Query: 108 ITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQ 167
             + G     ++  E E+      E+ DA E+E   + +E   ++   + +     T Q 
Sbjct: 573 TPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQL 632

Query: 168 VGDLTFK----------KGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQ 217
             +  +K          +  + L+ +KK +     K  +G E L      +   EEEE Q
Sbjct: 633 ALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRK---EEEEKQ 689

Query: 218 ESSEEGSEEDVEAVDETADGAEVKQRTD 245
           +  +E  E+  E + E    AE KQR D
Sbjct: 690 KRLQE--EKTQEKIQEEERKAEEKQRKD 715


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 36/109 (33%), Positives = 53/109 (48%), Gaps = 6/109 (5%)

Query: 131  GEEEDAEEEEE----EKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKP 186
            G E   EE E       ++  S  +S GEEYIA+  +++ + GDLTF +GE +LV +K  
Sbjct: 956  GSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-- 1013

Query: 187  DGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETA 235
            DG W         G+ P  Y++P  +E  G  S    S +  E    T+
Sbjct: 1014 DGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTS 1062



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 56/236 (23%), Positives = 101/236 (42%), Gaps = 25/236 (10%)

Query: 2   LARRQRDPLQALRRRNQELKQQVDSL--------LSESQLKEALEP-NKRQHIYQRCIQL 52
           L +R ++ L AL +       ++DS         + +S L+  L   +   +++    +L
Sbjct: 591 LCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKEL 650

Query: 53  KQAIDENKNALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVG 112
           ++  +  + AL++L K           +RK  E     KL  +    A    +EN+ +  
Sbjct: 651 RETYNTQQLALEQLYKIKRDK--LKEIERKRLELMQKKKLEDEAARKAKQ-GKENLWKEN 707

Query: 113 APTEEEEESESEDSEDSGGEEEDAEEEEEEK----------EENESHKWSTGEEYIAVGD 162
              EEEE+ +    E +  + ++ E + EEK          EE +    S    Y A+  
Sbjct: 708 LRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYP 767

Query: 163 FTAQQVGDLTFKKGEILLVIEKK-PDGWWIAKDAKGNEGLVPRTYLE--PYSEEEE 215
           F A+   +++F  G+I+ V EK   +  W+    +GN G  P  Y+E  P SE E+
Sbjct: 768 FEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 823



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 1/63 (1%)

Query: 156  EYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEE 215
            + IA+ D+ A    +L+F KG+++ V+ K    WW   +  G  GL P  Y++  ++ + 
Sbjct: 1131 QVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWW-QGEINGVTGLFPSNYVKMTTDSDP 1189

Query: 216  GQE 218
             Q+
Sbjct: 1190 SQQ 1192



 Score = 33.9 bits (76), Expect = 0.55
 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 2/63 (3%)

Query: 159 AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQE 218
           A+  +TA++   L F K +I+ V+E++ + WW   +  G  G  P++Y++     E  +E
Sbjct: 905 ALCSWTAKKDNHLNFSKHDIITVLEQQ-ENWWFG-EVHGGRGWFPKSYVKIIPGSEVKRE 962

Query: 219 SSE 221
             E
Sbjct: 963 EPE 965


>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
          Length = 1249

 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 36/109 (33%), Positives = 53/109 (48%), Gaps = 6/109 (5%)

Query: 131  GEEEDAEEEEE----EKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKP 186
            G E   EE E       ++  S  +S GEEYIA+  +++ + GDLTF +GE +LV +K  
Sbjct: 956  GSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-- 1013

Query: 187  DGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETA 235
            DG W         G+ P  Y++P  +E  G  S    S +  E    T+
Sbjct: 1014 DGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTS 1062



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 56/236 (23%), Positives = 101/236 (42%), Gaps = 25/236 (10%)

Query: 2   LARRQRDPLQALRRRNQELKQQVDSL--------LSESQLKEALEP-NKRQHIYQRCIQL 52
           L +R ++ L AL +       ++DS         + +S L+  L   +   +++    +L
Sbjct: 591 LCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKEL 650

Query: 53  KQAIDENKNALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVG 112
           ++  +  + AL++L K           +RK  E     KL  +    A    +EN+ +  
Sbjct: 651 RETYNTQQLALEQLYKIKRDK--LKEIERKRLELMQKKKLEDEAARKAKQ-GKENLWKEN 707

Query: 113 APTEEEEESESEDSEDSGGEEEDAEEEEEEK----------EENESHKWSTGEEYIAVGD 162
              EEEE+ +    E +  + ++ E + EEK          EE +    S    Y A+  
Sbjct: 708 LRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYP 767

Query: 163 FTAQQVGDLTFKKGEILLVIEKK-PDGWWIAKDAKGNEGLVPRTYLE--PYSEEEE 215
           F A+   +++F  G+I+ V EK   +  W+    +GN G  P  Y+E  P SE E+
Sbjct: 768 FEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 823



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 1/63 (1%)

Query: 156  EYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEE 215
            + IA+ D+ A    +L+F KG+++ V+ K    WW   +  G  GL P  Y++  ++ + 
Sbjct: 1131 QVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWW-QGEINGVTGLFPSNYVKMTTDSDP 1189

Query: 216  GQE 218
             Q+
Sbjct: 1190 SQQ 1192



 Score = 33.9 bits (76), Expect = 0.55
 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 2/63 (3%)

Query: 159 AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQE 218
           A+  +TA++   L F K +I+ V+E++ + WW   +  G  G  P++Y++     E  +E
Sbjct: 905 ALCSWTAKKDNHLNFSKHDIITVLEQQ-ENWWFG-EVHGGRGWFPKSYVKIIPGSEVKRE 962

Query: 219 SSE 221
             E
Sbjct: 963 EPE 965


>gi|11342676 thyroid hormone receptor interactor 10 [Homo sapiens]
          Length = 545

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 53/207 (25%), Positives = 87/207 (42%), Gaps = 14/207 (6%)

Query: 9   PLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENKNALQKLSK 68
           P Q  +R  Q+L+++   L  E   +EAL+  K + +Y++  Q+           + LS 
Sbjct: 340 PEQQRKRLQQQLEERSRELQKEVDQREALK--KMKDVYEKTPQMGDPASLEPQIAETLSN 397

Query: 69  ADE-SAPVANYNQ-RKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDS 126
            +     V  Y     E E  +L      L   A    R       AP +    S S+D+
Sbjct: 398 IERLKLEVQKYEAWLAEAESRVLSNRGDSLSRHA----RPPDPPASAPPDSSSNSASQDT 453

Query: 127 EDSGGEEEDAEEEE-----EEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLV 181
           ++S  E    E ++     E  E+ E    S     +A+  F     G ++  +GE L +
Sbjct: 454 KESSEEPPSEESQDTPIYTEFDEDFEEEPTSPIGHCVAIYHFEGSSEGTISMAEGEDLSL 513

Query: 182 IEK-KPDGWWIAKDAKGNEGLVPRTYL 207
           +E+ K DGW   +  +G EG VP +YL
Sbjct: 514 MEEDKGDGWTRVRRKEGGEGYVPTSYL 540


>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           3 [Homo sapiens]
          Length = 526

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 53/187 (28%), Positives = 76/187 (40%), Gaps = 23/187 (12%)

Query: 84  EEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEK 143
           EE  LL  L         T S E+ +       EEEE E E+ E+ G   E++EEEEEE+
Sbjct: 2   EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE 61

Query: 144 EENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGE-------ILLVIEKKPDGWWIAKDAK 196
           EE E    S  EE     + +A++V +    + E       +L+V E + D     +D+ 
Sbjct: 62  EEEEEETGSNSEE---ASEQSAEEVSEEEMSEDEERENENHLLVVPESRFD-----RDSG 113

Query: 197 GNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAIS 256
            +E        E   E  EG   S   +E D           E+KQ    +  A+Q   S
Sbjct: 114 ESE--------EAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRS 165

Query: 257 EAGIFCL 263
                CL
Sbjct: 166 VEEFQCL 172


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 50/161 (31%), Positives = 73/161 (45%), Gaps = 18/161 (11%)

Query: 80  QRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEE 139
           ++KE E     +  Q+++        E   E G   EEEEE E E  E+  GEE + E E
Sbjct: 711 EQKEREQGHQKERNQEMEEGGEEEHGEGEEEEG-DREEEEEKEGEGKEEGEGEEVEGERE 769

Query: 140 EEE---KEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAK 196
           +EE   K+E  + K   GEE    G+   ++    T  +GE     EK+  G     + +
Sbjct: 770 KEEGERKKEERAGKEEKGEEEGDQGEGEEEE----TEGRGE-----EKEEGG-----EVE 815

Query: 197 GNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADG 237
           G E    +   E   EE EG+E   EG EE+ E  +E  +G
Sbjct: 816 GGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEG 856



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 44/132 (33%), Positives = 59/132 (44%), Gaps = 19/132 (14%)

Query: 106 ENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTA 165
           E   E G   EEE E E E+ E  G EE +  E EEE EE E      GEE    G+   
Sbjct: 834 EGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGE----GEEEEGEGEGEE 889

Query: 166 QQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSE 225
           +  G+   ++GE     E + +G    ++ +G EG            EEEG+E   EG E
Sbjct: 890 EGEGEGEEEEGE----GEGEEEGEGEGEEEEG-EG----------KGEEEGEEGEGEGEE 934

Query: 226 EDVEAVDETADG 237
           E+ E   E  +G
Sbjct: 935 EEGEGEGEDGEG 946



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 41/124 (33%), Positives = 57/124 (45%), Gaps = 13/124 (10%)

Query: 112  GAPTEEEEESESEDSEDSG--------GEEEDAEEEEEEKEENESHKW-STGEEYIAVGD 162
            G   EEE E E ED E  G        GEEE+ E E EE+ E E  +    GEE    G+
Sbjct: 930  GEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGE 989

Query: 163  FTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEE 222
               ++  +   ++GE     E++ +G    ++    EG V     E   EEEEG+E  EE
Sbjct: 990  GEEEEGEEEGEEEGE----GEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEE 1045

Query: 223  GSEE 226
              +E
Sbjct: 1046 REKE 1049



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 39/130 (30%), Positives = 59/130 (45%), Gaps = 15/130 (11%)

Query: 116  EEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKK 175
            EEE E E E+ E  G EEE   E EEE+ E E  +   GEE    G+   ++ G++   +
Sbjct: 967  EEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEE-GEGEGEEEEEGEV---E 1022

Query: 176  GEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETA 235
            GE+     +  +G    ++ +G E    R       +E EG+E+     EE+ E      
Sbjct: 1023 GEV-----EGEEGEGEGEEEEGEEEGEER------EKEGEGEENRRNREEEEEEEGKYQE 1071

Query: 236  DGAEVKQRTD 245
             G E  +R D
Sbjct: 1072 TGEEENERQD 1081



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 45/169 (26%), Positives = 73/169 (43%), Gaps = 22/169 (13%)

Query: 71  ESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSG 130
           E   V    +++E E    ++  ++ +G       E   + G   EEE E   E+ E+ G
Sbjct: 760 EGEEVEGEREKEEGERKKEERAGKEEKG-------EEEGDQGEGEEEETEGRGEEKEE-G 811

Query: 131 GEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWW 190
           GE E  E EE + E  E  +   GEE    G+   ++ G+   ++GE     + + +G  
Sbjct: 812 GEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE---EEEGEGEEEEGEG----KGEEEGEE 864

Query: 191 IAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAE 239
              + +G EG       E   EEEEG+   EE  E + E  +   +G E
Sbjct: 865 GEGEEEGEEG-------EGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEE 906



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 40/131 (30%), Positives = 61/131 (46%), Gaps = 12/131 (9%)

Query: 112 GAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQ-QVGD 170
           G   EE +    E+ E+  GEEE+ E EEEE E  E      GEE    G+   + + G+
Sbjct: 816 GGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGE 875

Query: 171 LTFKKGEILLVIEKKPDGWWIAKDAKG---NEGLVPRTYLEPYSEEEEGQ-ESSEEGSEE 226
              ++ E     E++ +G    ++ +G    EG       E   EEEEG+ +  EEG E 
Sbjct: 876 GEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEG-------EGEGEEEEGEGKGEEEGEEG 928

Query: 227 DVEAVDETADG 237
           + E  +E  +G
Sbjct: 929 EGEGEEEEGEG 939



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 45/133 (33%), Positives = 58/133 (43%), Gaps = 20/133 (15%)

Query: 110  EVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVG 169
            E G    EEEE E E      GEEE+ EEE EE+ E E      GEE    G+   +  G
Sbjct: 975  EEGEGEGEEEEGEGE------GEEEEGEEEGEEEGEGEEEGEGEGEEE-EEGEVEGEVEG 1027

Query: 170  DLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVE 229
            +    +GE     E + +G    K+ +G E    R       EEEE  +  E G EE   
Sbjct: 1028 EEGEGEGE---EEEGEEEGEEREKEGEGEENRRNRE-----EEEEEEGKYQETGEEE--- 1076

Query: 230  AVDETADGAEVKQ 242
              +E  DG E K+
Sbjct: 1077 --NERQDGEEYKK 1087



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 42/130 (32%), Positives = 59/130 (45%), Gaps = 21/130 (16%)

Query: 112  GAPTEEEEESESEDSEDSG-GEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGD 170
            G   EE EE E E  E+ G GE ED E E EE+E     +W  GEE    G+   +  G+
Sbjct: 919  GKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEE----GEWE-GEEEEGEGEGEEEGEGE 973

Query: 171  LTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSE-EGSEEDVE 229
                +GE      ++ +G    ++ +G          E   EE EG+E  E EG EE+  
Sbjct: 974  GEEGEGE-----GEEEEGEGEGEEEEGE---------EEGEEEGEGEEEGEGEGEEEEEG 1019

Query: 230  AVDETADGAE 239
             V+   +G E
Sbjct: 1020 EVEGEVEGEE 1029



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 52/219 (23%), Positives = 90/219 (41%), Gaps = 47/219 (21%)

Query: 55  AIDENKNALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQ---GLAVTISR------ 105
           A D   N +++         V  +  RKE+   L D LT + +   G A ++        
Sbjct: 593 AEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPE 652

Query: 106 ---ENITEVGAPTEE--EEESESEDSEDSG---------GEEEDAE---------EEEEE 142
              +   E G+   E  ++E   +  +D G         GE+E AE         EE+E+
Sbjct: 653 GRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQ 712

Query: 143 KEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLV 202
           KE  + H+    +E    G+   ++ G+   ++G+     EK+ +G    ++ +G E   
Sbjct: 713 KEREQGHQKERNQEMEEGGE---EEHGEGEEEEGDREEEEEKEGEG---KEEGEGEE--- 763

Query: 203 PRTYLEPYSEEEEGQESSEE--GSEEDVEAVDETADGAE 239
               +E   E+EEG+   EE  G EE  E   +  +G E
Sbjct: 764 ----VEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEE 798



 Score = 33.1 bits (74), Expect = 0.94
 Identities = 20/53 (37%), Positives = 26/53 (49%), Gaps = 1/53 (1%)

Query: 106  ENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEE-NESHKWSTGEEY 157
            E   E G    EE E E E  E+    EE+ EEE + +E   E ++   GEEY
Sbjct: 1033 EGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEY 1085



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 39/147 (26%), Positives = 64/147 (43%), Gaps = 17/147 (11%)

Query: 100 AVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIA 159
           A TI   +  EV  P   EE+  +EDS+ +G EE++ E  EE  + +   K  T    I 
Sbjct: 573 ATTIEAFSDEEVEIP---EEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKT---EIL 626

Query: 160 VGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQES 219
             D T +   +++  K + +   E  P+G       +G+ G       E + +EE  +  
Sbjct: 627 SDDLTDK--AEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSG------AEHWQDEEREKGE 678

Query: 220 SEEG---SEEDVEAVDETADGAEVKQR 243
            ++G    E   E   E A+  E K+R
Sbjct: 679 KDKGRGEMERPGEGEKELAEKEEWKKR 705


>gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
           [Homo sapiens]
          Length = 304

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 26/72 (36%), Positives = 41/72 (56%), Gaps = 1/72 (1%)

Query: 156 EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEE 214
           EY+ A+ DF      DL FKKG+IL + +K  + WW A+D++G  G++P  Y+E Y    
Sbjct: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPAS 194

Query: 215 EGQESSEEGSEE 226
               +   G++E
Sbjct: 195 ASVSALIGGNQE 206


>gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b
           [Homo sapiens]
          Length = 204

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 24/56 (42%), Positives = 36/56 (64%), Gaps = 1/56 (1%)

Query: 156 EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY 210
           EY+ A+ DF      DL FKKG+IL + +K  + WW A+D++G  G++P  Y+E Y
Sbjct: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKY 190


>gi|109689723 abl interactor 2 [Homo sapiens]
          Length = 475

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 39/120 (32%), Positives = 58/120 (48%), Gaps = 13/120 (10%)

Query: 105 RENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEE------NESHKWSTG---E 155
           +ENI++   P    EE   ++S       ED EEEE    E       E   W+     E
Sbjct: 357 QENISDTPPPPPPVEEPVFDESPPPPPPPEDYEEEEAAVVEYSDPYAEEDPPWAPRSYLE 416

Query: 156 EYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEP---YSE 212
           + +A+ D+T  +  +L+F++G I+ VI+K  DGW+      G  GL P  Y+E    YSE
Sbjct: 417 KVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEGV-MNGVTGLFPGNYVESIMHYSE 475


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 75/314 (23%), Positives = 119/314 (37%), Gaps = 87/314 (27%)

Query: 15  RRNQELKQQVDSLLSESQL--KEALEPNKRQHIYQRCIQLKQAIDENKNALQKLSKADES 72
           R+ Q+ K++ + L  E +L  K   E   R     + +Q +     +K++L K       
Sbjct: 389 RKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPK------K 442

Query: 73  APVANYNQRKEEEHTLLDKLTQQLQGLAVTISRE-----NITEVGAPTEEE-----EESE 122
            P+    +RK        K+ QQL+   V+ S E      + E G P +EE     E  E
Sbjct: 443 RPIYEDKKRK--------KIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEE 494

Query: 123 SEDSEDSG-----------------------------GEEEDAEEEEEEKEENESHKWST 153
            ED+ED+G                              EEE+ EEEEEE EE+E  +   
Sbjct: 495 EEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEE 554

Query: 154 GEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEE 213
           GE   + GD   ++V D    + +    ++KKP                           
Sbjct: 555 GESEGSEGDEEDEKVSD----EKDSGKTLDKKP--------------------------S 584

Query: 214 EEGQESSEEGSEEDVEAVDETADGAE--VKQRTDPHWSAVQKAISEAGIFCLVNHVSFCY 271
           +E    SE  S++D    +   D A+  +++R   H   V      A I C++ HV    
Sbjct: 585 KEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGK 644

Query: 272 LIVLMRNRMETVED 285
             +L + R   V+D
Sbjct: 645 TKILDKLRHTHVQD 658



 Score = 34.7 bits (78), Expect = 0.32
 Identities = 29/103 (28%), Positives = 49/103 (47%), Gaps = 12/103 (11%)

Query: 57  DENKNALQKLSKADE------SAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITE 110
           DE K  L+KL + +E             +QRK EE T+  K+T       +  S E   +
Sbjct: 244 DEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTG--VIPASEE---K 298

Query: 111 VGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWST 153
              PT  E+++E  D +    +++  E+EE+EKE+ +    +T
Sbjct: 299 AETPTAAEDDNEG-DKKKKDKKKKKGEKEEKEKEKKKGPSKAT 340



 Score = 30.0 bits (66), Expect = 8.0
 Identities = 31/162 (19%), Positives = 73/162 (45%), Gaps = 14/162 (8%)

Query: 2   LARRQRDPLQALRRRNQELKQQVDSLLSESQLKEALEPNKRQHIYQR-----CIQLKQAI 56
           +A+++ +  +  R++  E K ++  L  + +L+   +   +Q   QR      ++ K  +
Sbjct: 228 VAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTV 287

Query: 57  D------ENKNALQKLSKADESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITE 110
           D        + A    +  D++        +K+++    +K  ++ +G +    +  + E
Sbjct: 288 DTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKA-MQE 346

Query: 111 VGAPTEEEEESESEDSED--SGGEEEDAEEEEEEKEENESHK 150
             A  +EEEE +  + E+     EE +A+ +EEE+ E E  +
Sbjct: 347 ALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRE 388


>gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-like
           [Homo sapiens]
          Length = 303

 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 24/54 (44%), Positives = 34/54 (62%), Gaps = 1/54 (1%)

Query: 156 EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLE 208
           EY+  + DF      DL FKKGEIL++IEK  + WW A++  G  G++P  Y+E
Sbjct: 126 EYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVE 179


>gi|21735415 centromere protein B [Homo sapiens]
          Length = 599

 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 42/133 (31%), Positives = 59/133 (44%), Gaps = 8/133 (6%)

Query: 116 EEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKK 175
           EEEEE E E+ E+  GEEE+ E EEEE+E  E  +    EE    GD  + +  +   + 
Sbjct: 407 EEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEEEEDEES 466

Query: 176 GEILLVIEKKPDGWWIAKDAKGNEGLVPRT------YLE--PYSEEEEGQESSEEGSEED 227
               L  E    G   A  + G  G           +LE    S+ +  +E  EE  +ED
Sbjct: 467 SSEGLEAEDWAQGVVEAGGSFGAYGAQEEAQCPTLHFLEGGEDSDSDSEEEDDEEEDDED 526

Query: 228 VEAVDETADGAEV 240
            +  D+  DG EV
Sbjct: 527 EDDDDDEEDGDEV 539



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 35/136 (25%), Positives = 56/136 (41%), Gaps = 22/136 (16%)

Query: 92  LTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKW 151
           LT+ L  +A        +++ A   E       ++  +   + + EEEEEE+EE E  + 
Sbjct: 361 LTEALHFVAAAWQAVEPSDIAACFREAGFGGGPNATITTSLKSEGEEEEEEEEEEEEEE- 419

Query: 152 STGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYS 211
             GEE    G+   ++ G+     GE L   E+  +   +  D                 
Sbjct: 420 GEGEEEEEEGEEEEEEGGE-----GEELGEEEEVEEEGDVDSD----------------E 458

Query: 212 EEEEGQESSEEGSEED 227
           EEEE +ESS EG E +
Sbjct: 459 EEEEDEESSSEGLEAE 474



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 13/45 (28%), Positives = 25/45 (55%)

Query: 116 EEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAV 160
           + + +SE ED E+   E+ED +++EE+ +E     +     Y A+
Sbjct: 509 DSDSDSEEEDDEEEDDEDEDDDDDEEDGDEVPVPSFGEAMAYFAM 553



 Score = 31.6 bits (70), Expect = 2.7
 Identities = 29/147 (19%), Positives = 66/147 (44%), Gaps = 17/147 (11%)

Query: 26  SLLSESQLKEALEPNKRQHIYQRCIQLKQAIDENKNA-----LQKLSKADESAPVANYNQ 80
           SL SE + +E  E  + +   +   + ++  +E +       L +  + +E   V +  +
Sbjct: 400 SLKSEGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEE 459

Query: 81  RKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTE------------EEEESESEDSED 128
            +E+E +  + L  +     V  +  +    GA  E            E+ +S+SE+ +D
Sbjct: 460 EEEDEESSSEGLEAEDWAQGVVEAGGSFGAYGAQEEAQCPTLHFLEGGEDSDSDSEEEDD 519

Query: 129 SGGEEEDAEEEEEEKEENESHKWSTGE 155
              ++ED +++++E++ +E    S GE
Sbjct: 520 EEEDDEDEDDDDDEEDGDEVPVPSFGE 546


>gi|17975763 myelin transcription factor 1 [Homo sapiens]
          Length = 1121

 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 43/149 (28%), Positives = 64/149 (42%), Gaps = 5/149 (3%)

Query: 20  LKQQVDSLLSESQLKEALEPNKR-QHIYQRCIQLKQAIDENKNALQKLSKADESAPVANY 78
           L Q  +  L E  L +A +P     H+ Q   +   + +  K    +   A+E   V   
Sbjct: 171 LGQIAEETLVEEDLGQAAKPGPGIVHLLQEAAEGAASEEGEKGLFIQPEDAEEVVEVTTE 230

Query: 79  NQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEE 138
             +     +L D  +++       +S E   E     EEEEE E E+ E+   EEE+ EE
Sbjct: 231 RSQDLCPQSLEDAASEESSKQKGILSHEEEDE----EEEEEEEEEEEDEEEEEEEEEEEE 286

Query: 139 EEEEKEENESHKWSTGEEYIAVGDFTAQQ 167
           EEEE+EE E  +    EE  A  D   Q+
Sbjct: 287 EEEEEEEEEEEEEEEEEEEEAAPDVIFQE 315



 Score = 31.6 bits (70), Expect = 2.7
 Identities = 32/136 (23%), Positives = 45/136 (33%), Gaps = 51/136 (37%)

Query: 119 EESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEI 178
           E++ SE+S    G     EE+EEE+EE E  +    EE                      
Sbjct: 241 EDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEE---------------------- 278

Query: 179 LLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGA 238
                                        E   EEEE +E  EE  EE+ E  +E     
Sbjct: 279 -----------------------------EEEEEEEEEEEEEEEEEEEEEEEEEEEEAAP 309

Query: 239 EVKQRTDPHWSAVQKA 254
           +V  + D   ++ QKA
Sbjct: 310 DVIFQEDTSHTSAQKA 325


>gi|55749544 SH3 multiple domains 1 [Homo sapiens]
          Length = 1105

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 25/74 (33%), Positives = 43/74 (58%), Gaps = 3/74 (4%)

Query: 155 EEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPY--SE 212
           E+Y+ V ++  Q+  +L+ + GE++ VIEK   GWW    ++  +G VP TYLE    + 
Sbjct: 169 EQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSE-EQGWVPATYLEAQNGTR 227

Query: 213 EEEGQESSEEGSEE 226
           ++    +S+ G EE
Sbjct: 228 DDSDINTSKTGEEE 241



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 27/102 (26%), Positives = 54/102 (52%), Gaps = 3/102 (2%)

Query: 137 EEEEEEKEENESHKWSTGEE--YIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKD 194
           E +   +++++ +   TGEE  Y+ V  +T+Q   ++ F+KG  + VI K  +GWW  + 
Sbjct: 221 EAQNGTRDDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIR- 279

Query: 195 AKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETAD 236
             G EG  P +YL+   ++   ++ +  G  E +  + E ++
Sbjct: 280 YLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISN 321



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 30/134 (22%), Positives = 54/134 (40%), Gaps = 7/134 (5%)

Query: 81   RKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEE 140
            R+ E  T  D L    +  + + +R    E      E   S+  DS     +        
Sbjct: 970  RRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPAQRNSIPVSP 1029

Query: 141  EEKEENESHKW---STGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWW---IAKD 194
               +  E  ++   +  + Y+++ D+   +     F++G  + V+E+ P+GWW   I   
Sbjct: 1030 VRPKPIEKSQFIHNNLKDVYVSIADYEGDEE-TAGFQEGVSMEVLERNPNGWWYCQILDG 1088

Query: 195  AKGNEGLVPRTYLE 208
             K  +G VP  YLE
Sbjct: 1089 VKPFKGWVPSNYLE 1102



 Score = 34.7 bits (78), Expect = 0.32
 Identities = 31/144 (21%), Positives = 56/144 (38%), Gaps = 16/144 (11%)

Query: 93  TQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENE----- 147
           +Q  + + ++  R  +   G      + S+SEDSE       +A  E   +  ++     
Sbjct: 739 SQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLP 798

Query: 148 --------SHKWS-TGEEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGN 198
                     +W      Y+    +   Q  +++F  G  + V+EK+  GWW  +  +  
Sbjct: 799 ATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGE-L 857

Query: 199 EGLVPRTYLEPYSEEEEGQESSEE 222
           EG  P  YL    E E+   S +E
Sbjct: 858 EGWAPSHYL-VLDENEQPDPSGKE 880



 Score = 33.9 bits (76), Expect = 0.55
 Identities = 15/53 (28%), Positives = 28/53 (52%), Gaps = 1/53 (1%)

Query: 156 EYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLE 208
           EY  + +F +     ++F+ G+   VI+K   GWW  +  +  EG  P +Y++
Sbjct: 424 EYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGE-KEGWAPASYID 475


>gi|68348709 formin binding protein 1-like isoform 1 [Homo sapiens]
          Length = 551

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 45/199 (22%), Positives = 84/199 (42%), Gaps = 10/199 (5%)

Query: 15  RRNQELKQQVDSL----LSESQLKEALEPNKRQHIYQRCIQLKQAIDENKNALQKLSKAD 70
           +R ++L+Q++D L      ES  K+AL  NK + +Y++  Q+           + ++  D
Sbjct: 344 QRRKKLQQRIDELNRELQKESDQKDAL--NKMKDVYEKNPQMGDPGSLQPKLAETMNNID 401

Query: 71  ESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSG 130
                 + N+    E   ++  T        +    ++   G  + E   ++  + E  G
Sbjct: 402 RLRMEIHKNEAWLSE---VEGKTGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRG 458

Query: 131 GEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEK-KPDGW 189
             ++     E + E  +           A+  F     G L  K+GE+L +IE+ K DGW
Sbjct: 459 PPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGW 518

Query: 190 WIAKDAKGNEGLVPRTYLE 208
             A+   G EG VP +Y++
Sbjct: 519 TRARRQNGEEGYVPTSYID 537


>gi|41581463 formin binding protein 1-like isoform 2 [Homo sapiens]
          Length = 547

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 45/199 (22%), Positives = 84/199 (42%), Gaps = 10/199 (5%)

Query: 15  RRNQELKQQVDSL----LSESQLKEALEPNKRQHIYQRCIQLKQAIDENKNALQKLSKAD 70
           +R ++L+Q++D L      ES  K+AL  NK + +Y++  Q+           + ++  D
Sbjct: 344 QRRKKLQQRIDELNRELQKESDQKDAL--NKMKDVYEKNPQMGDPGSLQPKLAETMNNID 401

Query: 71  ESAPVANYNQRKEEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSG 130
                 + N+    E   ++  T        +    ++   G  + E   ++  + E  G
Sbjct: 402 RLRMEIHKNEAWLSE---VEGKTGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRG 458

Query: 131 GEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKKGEILLVIEK-KPDGW 189
             ++     E + E  +           A+  F     G L  K+GE+L +IE+ K DGW
Sbjct: 459 PPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGW 518

Query: 190 WIAKDAKGNEGLVPRTYLE 208
             A+   G EG VP +Y++
Sbjct: 519 TRARRQNGEEGYVPTSYID 537


>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
          Length = 4374

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 25/74 (33%), Positives = 45/74 (60%), Gaps = 1/74 (1%)

Query: 75   VANYNQRKEEEHTLLDKLTQQL-QGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEE 133
            V+   + + +E  L+D+    L Q   +  +RE+   +  P +EEE ++ EDS  S  +E
Sbjct: 2369 VSRSGEDESQEDVLMDEAPSNLSQASTLQANREDSMNILDPEDEEEHTQEEDSSGSNEDE 2428

Query: 134  EDAEEEEEEKEENE 147
            +D+++EEEE+EE+E
Sbjct: 2429 DDSQDEEEEEEEDE 2442



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 9/62 (14%)

Query: 83   EEEHTLLDKLTQQLQGLAVTISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEE 142
            EEEHT  +  +          S E+  +     EEEEE E +D ED  GEE D +++++ 
Sbjct: 2412 EEEHTQEEDSSG---------SNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDG 2462

Query: 143  KE 144
             E
Sbjct: 2463 SE 2464


>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
          Length = 1321

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 16/114 (14%)

Query: 116 EEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEEYIAVGDFTAQQVGDLTFKK 175
           EEEEE E E+ E+   EEE+ EEEEEE+EE E  +       +A+G+    + G  +  +
Sbjct: 734 EEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAAAVALGEVLGPRSG--SSSE 791

Query: 176 GEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEEEGQESSEEGSEEDVE 229
           G      E+  D        +  EG  P T L    +E  G+ S  +G  E  E
Sbjct: 792 GS-----ERSTD--------RSQEG-APSTLLADDQKESRGRASMADGDLEPEE 831


>gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a
           [Homo sapiens]
          Length = 1071

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 47/186 (25%), Positives = 75/186 (40%), Gaps = 25/186 (13%)

Query: 101 VTISRENI----TEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEE--KEENESHKWSTG 154
           + I  ENI     E+  P      S  +  +   GE    E+  ++   E + S      
Sbjct: 671 IIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEP 730

Query: 155 EEYIAVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEE 214
            E IA  D+  +   +L+FKKG  LL+ ++  D WW  +   G +GL+P  Y+     E+
Sbjct: 731 IEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRH-NGIDGLIPHQYIVVQDTED 789

Query: 215 EGQESSEEGSEEDVEAVDETADGAEVKQRTDPHWSAVQKAISEAGIFC-LVNHVSFCYLI 273
              E S   SE  +E + E  +               +K  + AG  C    HV+  YL 
Sbjct: 790 GVVERSSPKSE--IEVISEPPE---------------EKVTARAGASCPSGGHVADIYLA 832

Query: 274 VLMRNR 279
            + + R
Sbjct: 833 NINKQR 838


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.133    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,689,866
Number of Sequences: 37866
Number of extensions: 1408602
Number of successful extensions: 32127
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 619
Number of HSP's successfully gapped in prelim test: 579
Number of HSP's that attempted gapping in prelim test: 13233
Number of HSP's gapped (non-prelim): 8958
length of query: 732
length of database: 18,247,518
effective HSP length: 110
effective length of query: 622
effective length of database: 14,082,258
effective search space: 8759164476
effective search space used: 8759164476
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.