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Search of human proteins with 189027048
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|189027048 ecto-NOX disulfide-thiol exchanger 1 [Homo
sapiens]
(643 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|189027048 ecto-NOX disulfide-thiol exchanger 1 [Homo sapiens] 1285 0.0
gi|189027046 ecto-NOX disulfide-thiol exchanger 1 [Homo sapiens] 1285 0.0
gi|32528291 ecto-NOX disulfide-thiol exchanger 2 isoform b [Homo... 836 0.0
gi|32528293 ecto-NOX disulfide-thiol exchanger 2 isoform a [Homo... 826 0.0
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 65 3e-10
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 64 4e-10
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 63 1e-09
gi|34577114 cytomatrix protein p110 [Homo sapiens] 61 3e-09
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 60 6e-09
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 60 8e-09
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 58 2e-08
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 58 2e-08
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 58 3e-08
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 57 5e-08
gi|45439327 periplakin [Homo sapiens] 57 7e-08
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 55 2e-07
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 55 2e-07
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 55 2e-07
gi|148746195 trichohyalin [Homo sapiens] 55 2e-07
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 55 2e-07
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 55 2e-07
gi|21735548 centrosomal protein 2 [Homo sapiens] 55 3e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 54 4e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 54 4e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 54 4e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 54 4e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 54 4e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 54 4e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 54 4e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 54 4e-07
>gi|189027048 ecto-NOX disulfide-thiol exchanger 1 [Homo sapiens]
Length = 643
Score = 1285 bits (3326), Expect = 0.0
Identities = 643/643 (100%), Positives = 643/643 (100%)
Query: 1 MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPV 60
MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPV
Sbjct: 1 MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPV 60
Query: 61 GLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSC 120
GLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSC
Sbjct: 61 GLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSC 120
Query: 121 TLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCH 180
TLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCH
Sbjct: 121 TLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCH 180
Query: 181 IRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREER 240
IRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREER
Sbjct: 181 IRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREER 240
Query: 241 HRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSA 300
HRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSA
Sbjct: 241 HRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSA 300
Query: 301 NQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQK 360
NQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQK
Sbjct: 301 NQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQK 360
Query: 361 AWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDES 420
AWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDES
Sbjct: 361 AWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDES 420
Query: 421 ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGM 480
ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGM
Sbjct: 421 ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGM 480
Query: 481 QQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
QQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN
Sbjct: 481 QQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
Query: 541 VLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSK 600
VLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSK
Sbjct: 541 VLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSK 600
Query: 601 ISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT 643
ISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT
Sbjct: 601 ISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT 643
>gi|189027046 ecto-NOX disulfide-thiol exchanger 1 [Homo sapiens]
Length = 643
Score = 1285 bits (3326), Expect = 0.0
Identities = 643/643 (100%), Positives = 643/643 (100%)
Query: 1 MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPV 60
MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPV
Sbjct: 1 MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPV 60
Query: 61 GLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSC 120
GLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSC
Sbjct: 61 GLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSC 120
Query: 121 TLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCH 180
TLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCH
Sbjct: 121 TLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCH 180
Query: 181 IRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREER 240
IRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREER
Sbjct: 181 IRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREER 240
Query: 241 HRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSA 300
HRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSA
Sbjct: 241 HRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSA 300
Query: 301 NQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQK 360
NQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQK
Sbjct: 301 NQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQK 360
Query: 361 AWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDES 420
AWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDES
Sbjct: 361 AWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDES 420
Query: 421 ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGM 480
ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGM
Sbjct: 421 ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGM 480
Query: 481 QQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
QQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN
Sbjct: 481 QQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
Query: 541 VLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSK 600
VLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSK
Sbjct: 541 VLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSK 600
Query: 601 ISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT 643
ISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT
Sbjct: 601 ISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT 643
>gi|32528291 ecto-NOX disulfide-thiol exchanger 2 isoform b [Homo
sapiens]
Length = 610
Score = 836 bits (2159), Expect = 0.0
Identities = 410/622 (65%), Positives = 503/622 (80%), Gaps = 29/622 (4%)
Query: 24 AADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPVGLPGQQLVSDSICVPGFDPSLNM 83
AAD ++ +D+T + + ++DPTAWATAMNNLGM P+G+ GQ ++ P FDP+L M
Sbjct: 16 AADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPIL------PDFDPALGM 69
Query: 84 MTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSCTLFPQNPNLPPPSTRERPPGCKT 143
MTGI PI PM+PGLG+VPPP P ++ VVKEIIHCKSCTLFP NPNLPPP+TRERPPGCKT
Sbjct: 70 MTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKT 129
Query: 144 VFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLG 203
VFVGGLPEN TE+II EVFEQCG+I AIRKSKKNFCHIRFAEE+MVDKA+YLSGYR+RLG
Sbjct: 130 VFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLG 189
Query: 204 SSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSE 263
SSTDKKD+GRLHVDFAQARDD YEWECKQRM AREERHRR++EE+RLRPPSPP ++HYS+
Sbjct: 190 SSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSD 249
Query: 264 HEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKAT 323
HE +++AEKLKDDSKFSEA+ LL+WIERGEVNRRSAN FYSM+QSANSHVRRL+NEKA
Sbjct: 250 HECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAA 309
Query: 324 HEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL 383
HE++MEEAKE FK AL+GIL QFEQIVAV++++++QKAWDHF+KAQRKNI +W K +EE+
Sbjct: 310 HEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEI 369
Query: 384 RNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAY 443
RN +++LMGIRREEEMEMSDDE + T+ +ESAL +QA ALKEENDSLRWQLDAY
Sbjct: 370 RNIHNDELMGIRREEEMEMSDDE-IEEMTETKETEESALVSQAEALKEENDSLRWQLDAY 428
Query: 444 RNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKE 503
RNEVELLKQE+ ++ R E++ K+QQL+ LQQ +QGMQQ LL +QEE K++ELE+ K+
Sbjct: 429 RNEVELLKQEQGKVHR-EDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKD 487
Query: 504 EQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEK--RSQG 561
++ + +L+ L+E+ L + NQD E +EK S
Sbjct: 488 DKLQVEKMLENLKEKESCASRLCAS-------------------NQDSEYPLEKTMNSSP 528
Query: 562 LKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLPRMFKQEF 621
+KSE+EALL+GIISTFLHVHPFGA+IEY+ SY+ +LD+KI +++E L+ RL FKQE
Sbjct: 529 IKSEREALLVGIISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEM 588
Query: 622 TGVGATLEKRWKLCAFEGIKTT 643
TGVGA+LEKRWK C FEG+K T
Sbjct: 589 TGVGASLEKRWKFCGFEGLKLT 610
>gi|32528293 ecto-NOX disulfide-thiol exchanger 2 isoform a [Homo
sapiens]
Length = 581
Score = 826 bits (2134), Expect = 0.0
Identities = 405/608 (66%), Positives = 494/608 (81%), Gaps = 29/608 (4%)
Query: 38 LNMSVTDPTAWATAMNNLGMVPVGLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGL 97
+ + ++DPTAWATAMNNLGM P+G+ GQ ++ P FDP+L MMTGI PI PM+PGL
Sbjct: 1 MTLPMSDPTAWATAMNNLGMAPLGIAGQPIL------PDFDPALGMMTGIPPITPMMPGL 54
Query: 98 GLVPPPPPTEVAVVKEIIHCKSCTLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEI 157
G+VPPP P ++ VVKEIIHCKSCTLFP NPNLPPP+TRERPPGCKTVFVGGLPEN TE+I
Sbjct: 55 GIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQI 114
Query: 158 IQEVFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVD 217
I EVFEQCG+I AIRKSKKNFCHIRFAEE+MVDKA+YLSGYR+RLGSSTDKKD+GRLHVD
Sbjct: 115 IVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVD 174
Query: 218 FAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDS 277
FAQARDD YEWECKQRM AREERHRR++EE+RLRPPSPP ++HYS+HE +++AEKLKDDS
Sbjct: 175 FAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDS 234
Query: 278 KFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKN 337
KFSEA+ LL+WIERGEVNRRSAN FYSM+QSANSHVRRL+NEKA HE++MEEAKE FK
Sbjct: 235 KFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQ 294
Query: 338 ALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRRE 397
AL+GIL QFEQIVAV++++++QKAWDHF+KAQRKNI +W K +EE+RN +++LMGIRRE
Sbjct: 295 ALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRRE 354
Query: 398 EEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQL 457
EEMEMSDDE + T+ +ESAL +QA ALKEENDSLRWQLDAYRNEVELLKQE+ ++
Sbjct: 355 EEMEMSDDE-IEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKV 413
Query: 458 FRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQE 517
R E++ K+QQL+ LQQ +QGMQQ LL +QEE K++ELE+ K+++ + +L+ L+E
Sbjct: 414 HR-EDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKE 472
Query: 518 QLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEK--RSQGLKSEKEALLIGIIS 575
+ L + NQD E +EK S +KSE+EALL+GIIS
Sbjct: 473 KESCASRLCAS-------------------NQDSEYPLEKTMNSSPIKSEREALLVGIIS 513
Query: 576 TFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLC 635
TFLHVHPFGA+IEY+ SY+ +LD+KI +++E L+ RL FKQE TGVGA+LEKRWK C
Sbjct: 514 TFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWKFC 573
Query: 636 AFEGIKTT 643
FEG+K T
Sbjct: 574 GFEGLKLT 581
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 64.7 bits (156), Expect = 3e-10
Identities = 66/299 (22%), Positives = 132/299 (44%), Gaps = 26/299 (8%)
Query: 222 RDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSE 281
R + WE +++MR +EE K E+ R + +M E + L EK+ + K E
Sbjct: 400 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE----MMWEKEEKIRELEEKMHEQEKIRE 455
Query: 282 AITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQE--MEEAKENFKNAL 339
E R+ + + + E+ EQE + E +E
Sbjct: 456 Q-----------EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQE 504
Query: 340 TGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEE 399
I Q E+I +++ W K R+ +IWR+ +E + Q E+ IR++EE
Sbjct: 505 EKIHEQ-EKIREEEKRQEQEEMWRQEEKI-REQEEIWRQ--KEKIHEQEEK---IRKQEE 557
Query: 400 MEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFR 459
+E +K+R E + Q ++E+ + +R Q + R + E+ ++++E++
Sbjct: 558 KMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGE 617
Query: 460 TEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQ 518
EE + +Q + +Q+ + M++Q I+E+ + + E+ +E++ Q + + EQ
Sbjct: 618 QEEKMC--EQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ 674
Score = 58.2 bits (139), Expect = 2e-08
Identities = 68/321 (21%), Positives = 132/321 (41%), Gaps = 40/321 (12%)
Query: 222 RDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSE-----HEAALLAEKLKDD 276
R + WE +++MR +EE K E+++R MH E E EK+++
Sbjct: 414 RQEEMMWEKEEKMRRQEEMMWEK--EEKIRELEEK--MHEQEKIREQEEKRQEEEKIREQ 469
Query: 277 SKFSEAITVLLSWIER----GEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAK 332
K E + E+ E R + + + + + EK ++EM +
Sbjct: 470 EKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 529
Query: 333 ENFKNALTGILTQFEQIVAVFNASTRQ--KAW-------DHFSKAQRKNIDIWRKHSEEL 383
E + I Q E+I +Q K W D K + + +WR+ E++
Sbjct: 530 EKIREQ-EEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQE-EKI 587
Query: 384 RNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAY 443
R EQ IR +EE +E +KM E + Q ++E+ + +R Q +
Sbjct: 588 R----EQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKI 643
Query: 444 RNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSEL----- 498
R + + +++++E++ EE + + ++ + Q+ Q++ + QEE ++ E
Sbjct: 644 REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 703
Query: 499 -------EQAKEEQSHTQALL 512
E+ +E Q H +A +
Sbjct: 704 VRLRQQEEKMQEHQEHLEAAI 724
Score = 54.3 bits (129), Expect = 3e-07
Identities = 89/441 (20%), Positives = 177/441 (40%), Gaps = 63/441 (14%)
Query: 163 EQCGDITAIRKSKKNFCHIRFAEEFMVDK-AIYLSGYRMRLGSSTDKKDSGRLHVDFAQA 221
EQ A +K K + R+ EE ++ A+ L YR + K+ + +L Q
Sbjct: 239 EQALSAVATQKKKAD----RYIEELTKERDALSLELYRNTITDEELKEKNAKL-----QE 289
Query: 222 RDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSE 281
+ E E K ++ + +RKLE +L P + EA L ++L+ S
Sbjct: 290 KLQLVESE-KSEIQLNVKELKRKLERAKLLLPQQQL-----QAEADHLGKELQSVS---- 339
Query: 282 AITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTG 341
L + +E E+ R Q + ++ + E+++ E +E +
Sbjct: 340 --AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEK 397
Query: 342 ILTQFEQIVAVFNASTRQKA--WDHFSKAQRKNIDIWRKHSE--ELRNAQSEQL----MG 393
+ Q E + RQ+ W+ K +R+ +W K + EL EQ
Sbjct: 398 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE 457
Query: 394 IRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRW--------------- 438
+R+EE ++ + E KM E + Q ++E+ + + W
Sbjct: 458 EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKM-WRQEEKIHEQEKIREE 516
Query: 439 -----QLDAYRNEVELLKQE-----KEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQ 488
Q + +R E ++ +QE KE++ EE + K ++ + Q+ Q++ + Q
Sbjct: 517 EKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQ 576
Query: 489 EELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVN 548
EE ++ E + +EE+ Q + ++EQ + T+E E G E E
Sbjct: 577 EEKVWRQEEKIREQEEKIREQE--EKIREQEEMTQEQEEKMGEQEEKMCEQEEKM----- 629
Query: 549 QDRENNIEKRSQGLKSEKEAL 569
Q++E + ++ + ++ +++ +
Sbjct: 630 QEQEEKMRRQEEKIREQEKKI 650
Score = 48.1 bits (113), Expect = 2e-05
Identities = 46/285 (16%), Positives = 128/285 (44%), Gaps = 21/285 (7%)
Query: 259 MHYSEH-------EAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSAN 311
++YS+H EA L +L D KF+ + LS + ++ A+++ +
Sbjct: 207 LYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVA---TQKKKADRYIEELTKER 263
Query: 312 SHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRK 371
+ + ++E++E + L L + E+ N ++ K +R
Sbjct: 264 DALSLELYRNTITDEELKEKNAKLQEKLQ--LVESEKSEIQLNVKELKR------KLERA 315
Query: 372 NIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKE 431
+ + ++ + + ++L + + + ++ ++E + ++ E + Q ++E
Sbjct: 316 KLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQ---EEKMWRQEEKIQE 372
Query: 432 ENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEEL 491
+ ++ Q + R + E +++++E++ R EE + + ++ Q+ M +++ + QEE+
Sbjct: 373 WEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM 432
Query: 492 NNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDS 536
+K E + EE+ H Q ++ +E+ + +++ E +++
Sbjct: 433 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA 477
Score = 41.6 bits (96), Expect = 0.002
Identities = 62/317 (19%), Positives = 128/317 (40%), Gaps = 42/317 (13%)
Query: 227 EWECK---QRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAI 283
EWE K Q + RE+ + + +E+++R M + + E E++ + +
Sbjct: 372 EWEEKIQEQEEKIREQEEKIREQEEKMRRQEE---MMWEKEEKMRRQEEMMWEKEEKMRR 428
Query: 284 TVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGIL 343
+ W E+ E R + + + +R EK +++ +E + I
Sbjct: 429 QEEMMW-EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 487
Query: 344 TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMS 403
Q E+I +K W Q + I K EE + + E++ R+EE ++
Sbjct: 488 EQEEKI-----REQEEKMW-----RQEEKIHEQEKIREEEKRQEQEEMW---RQEE-KIR 533
Query: 404 DDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQE---------- 453
+ E +K+ E + K+E R + + E ++ +QE
Sbjct: 534 EQEEIWRQKEKIHEQEEKIR------KQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKI 587
Query: 454 ---KEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQA 510
+E++ EE + + +++ Q+ G Q++ + QEE ++ E + +EE+ Q
Sbjct: 588 REQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQE 647
Query: 511 LLKVLQEQLKGTKELVE 527
K ++EQ + +E E
Sbjct: 648 --KKIREQEEKIREQEE 662
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 63.9 bits (154), Expect = 4e-10
Identities = 56/300 (18%), Positives = 137/300 (45%), Gaps = 25/300 (8%)
Query: 222 RDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSE 281
R + WE +++MR +EE K E+ R +M E + L EK+ + K E
Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEE----MMWEKEEKIRELEEKMHEQEKIRE 394
Query: 282 AITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTG 341
E R+ + + + E+ EQE E+ +E K
Sbjct: 395 Q-----------EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE-EKIREQEKKMWRQ 442
Query: 342 I--LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEE 399
+ + E+I +++ W K R+ +IWR+ +E + Q + IR++EE
Sbjct: 443 EEKIHEQEKIREEEKRQEQEEMWRQEEKI-REQEEIWRQ--KEKMHEQEK----IRKQEE 495
Query: 400 MEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFR 459
+E +K+R E + Q ++E+ + +R Q + R + E++++++E++
Sbjct: 496 KVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGE 555
Query: 460 TEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQL 519
EE + + ++++ ++ ++ ++++ +E++ ++ ++ + +E+ + +++ +E++
Sbjct: 556 QEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKM 615
Score = 57.0 bits (136), Expect = 5e-08
Identities = 60/307 (19%), Positives = 134/307 (43%), Gaps = 33/307 (10%)
Query: 228 WECKQRMRAREER----------HRRKLEEDRLRPPSP----PAIMHYSEHEAALLAEKL 273
WE ++++R EE+ ++ EE+++R A M E + EK+
Sbjct: 373 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 432
Query: 274 KDDSK--FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQE-MEE 330
++ K + + + R E R+ + + + ++ HEQE + +
Sbjct: 433 REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRK 492
Query: 331 AKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQS-- 388
+E + Q E+I +K W K + + I R+ E++R +
Sbjct: 493 QEEKVWRQEEKMHDQEEKI-----REQEEKMWRQEEKIREQEEKI-REQEEKIREQEEMM 546
Query: 389 ---EQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRN 445
E+ MG E+E +M + E +K+R E + Q ++E+ + + Q + R
Sbjct: 547 QEQEEKMG---EQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIRE 603
Query: 446 EVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQ 505
+ E++++++E+++ EE + +Q + +Q+ + M++Q + E+ + + E+ +E Q
Sbjct: 604 QEEMMQEQEEKMWEQEEKMC--EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 661
Query: 506 SHTQALL 512
H +A +
Sbjct: 662 EHLEAAI 668
Score = 53.1 bits (126), Expect = 8e-07
Identities = 63/324 (19%), Positives = 140/324 (43%), Gaps = 29/324 (8%)
Query: 222 RDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSE-----HEAALLAEKLKDD 276
R + WE +++MR EE K E+++R MH E E EK+++
Sbjct: 353 RQEEMMWEKEEKMRRLEEMMWEK--EEKIRELEEK--MHEQEKIREQEEKRQEEEKIREQ 408
Query: 277 SKFSEAITVLLSWIER----GEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAK 332
K E + E+ E R + + + + + EK ++EM +
Sbjct: 409 EKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 468
Query: 333 ENFKNALTGILTQFEQIVAVFNASTRQ-KAW-------DHFSKAQRKNIDIWRKHSEELR 384
E + I Q E++ ++ K W D K + + +WR+ EE
Sbjct: 469 EKIREQ-EEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQ--EEKI 525
Query: 385 NAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYR 444
Q E++ RE+E ++ + E ++ ++ + ++ + + +R Q + R
Sbjct: 526 REQEEKI----REQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIR 581
Query: 445 NEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE 504
+ E +++++E+++ EE + + +++ Q+ Q++ + QEE ++ E + +EE
Sbjct: 582 EQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 641
Query: 505 QSHTQAL-LKVLQEQLKGTKELVE 527
+ Q + L+ +E+++ +E +E
Sbjct: 642 KMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 45.8 bits (107), Expect = 1e-04
Identities = 57/315 (18%), Positives = 131/315 (41%), Gaps = 36/315 (11%)
Query: 227 EWECK---QRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAI 283
EWE K Q + RE+ + + +E+++R M + + E E++ + +
Sbjct: 311 EWEEKIQEQEEKIREQEEKIREQEEKMRRQEE---MMWEKEEKMRRQEEMMWEKEEKMRR 367
Query: 284 TVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGIL 343
+ W E+ E R + + + +R EK +++ +E + I
Sbjct: 368 LEEMMW-EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 426
Query: 344 TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMS 403
Q E+I +K W Q + I K EE + + E++ R+EE ++
Sbjct: 427 EQEEKI-----REQEKKMW-----RQEEKIHEQEKIREEEKRQEQEEMW---RQEE-KIR 472
Query: 404 DDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEEN 463
+ E +KM E ++++ + + Q + ++ E +++++E+++R EE
Sbjct: 473 EQEEIWRQKEKMHEQEK--------IRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEK 524
Query: 464 LTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTK 523
+ + Q+ Q++ + QEE+ ++ E +EE+ Q ++ +E+++ +
Sbjct: 525 IRE-------QEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQE 577
Query: 524 ELVETNGHSHEDSNE 538
E + + E
Sbjct: 578 EKIREQKEKIREQEE 592
Score = 45.4 bits (106), Expect = 2e-04
Identities = 45/285 (15%), Positives = 127/285 (44%), Gaps = 21/285 (7%)
Query: 259 MHYSEH-------EAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSAN 311
++YS+H EA L +L D KF+ + LS + ++ A+++ +
Sbjct: 146 LYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVA---TQKKKADRYIEELTKER 202
Query: 312 SHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRK 371
+ + ++E++E + L L + E+ N ++ K +R
Sbjct: 203 DALSLELYRNTITDEELKEKNAKLQEKLQ--LVESEKSEIQLNVKELKR------KLERA 254
Query: 372 NIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKE 431
+ + ++ + + ++L + + + ++ ++E + ++ E + Q ++E
Sbjct: 255 KLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQ---EEKMWRQEEKIQE 311
Query: 432 ENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEEL 491
+ ++ Q + R + E +++++E++ R EE + + ++ Q+ M +++ + EE+
Sbjct: 312 WEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEM 371
Query: 492 NNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDS 536
+K E + EE+ H Q ++ +E+ + +++ E +++
Sbjct: 372 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA 416
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 62.8 bits (151), Expect = 1e-09
Identities = 60/310 (19%), Positives = 130/310 (41%), Gaps = 17/310 (5%)
Query: 220 QARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKF 279
Q + E E +Q A+ R K+ E + M + + E EK++++ K
Sbjct: 414 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKM-WRQEEKIHEQEKIREEEKR 472
Query: 280 SEAITVLLSWIERGEVN--------RRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEA 331
E + W + +++ + ++ ++ V R + E+++ E
Sbjct: 473 QEQEEM---WRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQ 529
Query: 332 KENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSE-- 389
+E I Q E ++K W+ K Q + +WR+ E++R + +
Sbjct: 530 EEKMWRQEEKIREQEEMWREEEKMHEQEKIWEE-EKRQEQEDKMWRQE-EKIREQEEKVW 587
Query: 390 -QLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVE 448
Q IR +EE +E +K+R E + Q ++E+ + +R Q + + + E
Sbjct: 588 RQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEE 647
Query: 449 LLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHT 508
+ +++E++ EE + + ++ + Q+ Q++ + QEE ++ E+ Q +EE+
Sbjct: 648 KMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 707
Query: 509 QALLKVLQEQ 518
Q QE+
Sbjct: 708 QEEKMCEQEE 717
Score = 53.5 bits (127), Expect = 6e-07
Identities = 75/384 (19%), Positives = 167/384 (43%), Gaps = 38/384 (9%)
Query: 163 EQCGDITAIRKSKKNFCHIRFAEEFMVDK-AIYLSGYRMRLGSSTDKKDSGRLHVDFAQA 221
EQ A +K K + R+ EE ++ A+ L YR + K+ + +L Q
Sbjct: 178 EQALSAVATQKKKAD----RYIEELTKERDALSLELYRNTITDEELKEKNAKL-----QE 228
Query: 222 RDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSE 281
+ E E K ++ + +RKLE +L P + EA L ++L+ S
Sbjct: 229 KLQLVESE-KSEIQLNVKELKRKLERAKLLLPQQQL-----QAEADHLGKELQSVS---- 278
Query: 282 AITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTG 341
L + +E E+ R Q + ++ + E+++ E +E +
Sbjct: 279 --AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEK 336
Query: 342 ILTQFEQIVAVFNASTRQKA--WDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIR---- 395
+ Q E + RQ+ W+ K +R+ +W K E++R + E++M +
Sbjct: 337 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE-EKMR--RQEEMMWEKEEKI 393
Query: 396 REEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRW-QLDAYRNEVELLKQEK 454
RE E +M + E +K + +E + ++E ++ W Q + R + E +++++
Sbjct: 394 RELEEKMHEQEKIREQEEKRQEEEKIREQEK---RQEQEAKMWRQEEKIREQEEKIREQE 450
Query: 455 EQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKV 514
++++R EE + + ++++ + + +Q+ + QEE +++ E+ + KE+ + ++
Sbjct: 451 KKMWRQEEKIHEQEKIR---EEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRK 507
Query: 515 LQEQLKGTKELVETNGHSHEDSNE 538
+E++ +E + + E
Sbjct: 508 QEEKVWRQEEKIREQEEKIREQEE 531
Score = 51.2 bits (121), Expect = 3e-06
Identities = 49/290 (16%), Positives = 127/290 (43%), Gaps = 17/290 (5%)
Query: 259 MHYSEH-------EAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSAN 311
++YS+H EA L +L D KF+ + LS + ++ A+++ +
Sbjct: 146 LYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVA---TQKKKADRYIEELTKER 202
Query: 312 SHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKA-QR 370
+ + ++E++E + L L + E+ N ++ + +
Sbjct: 203 DALSLELYRNTITDEELKEKNAKLQEKLQ--LVESEKSEIQLNVKELKRKLERAKLLLPQ 260
Query: 371 KNIDIWRKH-SEELRNAQSEQLMGIRREE---EMEMSDDENCDSPTKKMRVDESALAAQA 426
+ + H +EL++ ++ + E + +E +K++ E + Q
Sbjct: 261 QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE 320
Query: 427 YALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLT 486
++E+ + +R Q + R + E++ +++E++ R EE + + ++ Q+ M +++ +
Sbjct: 321 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 380
Query: 487 IQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDS 536
QEE+ +K E + EE+ H Q ++ +E+ + +++ E +++
Sbjct: 381 RQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA 430
Score = 50.4 bits (119), Expect = 5e-06
Identities = 59/295 (20%), Positives = 119/295 (40%), Gaps = 38/295 (12%)
Query: 228 WECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKL-KDDSKFSEAITVL 286
W ++++ +EE R+K + MH E + EK+ + + K E
Sbjct: 479 WRQEEKIHEQEEIWRQKEK------------MHEQEEKIRKQEEKVWRQEEKIRE----- 521
Query: 287 LSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQF 346
+ E R + + + E+ HEQE +E + + Q
Sbjct: 522 -----QEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQE 576
Query: 347 EQIVAVFNASTRQ--KAWDHFSKAQRKNIDIWRKHSEELRNAQS----------EQLMGI 394
E+I RQ K + K Q + +W K E++R + EQ I
Sbjct: 577 EKIREQEEKVWRQEEKIREQEEKRQEQEEKMW-KQEEKIREQEEKIQEQEEKIREQEEKI 635
Query: 395 RREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEK 454
R +EEM +E +KM E + Q + + + +R Q R + E +++++
Sbjct: 636 REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQE 695
Query: 455 EQLFRTEENL-TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE-QSH 507
E + EE + +++++ ++ MQ ++++ +E++ ++ L Q +E+ Q H
Sbjct: 696 EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEH 750
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 61.2 bits (147), Expect = 3e-09
Identities = 75/370 (20%), Positives = 159/370 (42%), Gaps = 45/370 (12%)
Query: 231 KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
KQ + AR+E ++ LE L+ P+ ++E ++ + + V+L
Sbjct: 295 KQTLNARDESIKKLLE--MLQSKGLPSKSLEDDNERT---RRMAEAESQVSHLEVILDQK 349
Query: 291 ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
E+ ++ R S +Q + + L + ++ + N ++ I Q +
Sbjct: 350 EKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEI--QMLKAN 407
Query: 351 AVFNASTRQKAWDHFSKAQRKNIDIWRKHS-----------EELRNAQSEQLMGIRREEE 399
V N R++ + K I++++ HS +EL +SE L+ ++ + E
Sbjct: 408 GVLNTEDREE--------EIKQIEVYKSHSKFMKTKIDQLKQELSKKESE-LLALQTKLE 458
Query: 400 MEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFR 459
+ + +C + ++ +A +A L+ E D+LR +L+ E L K+ K+
Sbjct: 459 TLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE--EKESFLNKKTKQLQDL 516
Query: 460 TEENLT--------------KDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQ 505
TEE T K++++ LQ+ ++ +Q+QL ++L N K ++ + +
Sbjct: 517 TEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDS 576
Query: 506 SHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRS--QGLK 563
S+T L L+E L + ++E E + + + ++ ++ EK + Q
Sbjct: 577 SNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAEL 636
Query: 564 SEKEALLIGI 573
+EKE+ LI +
Sbjct: 637 TEKESSLIDL 646
Score = 37.4 bits (85), Expect = 0.043
Identities = 88/421 (20%), Positives = 158/421 (37%), Gaps = 49/421 (11%)
Query: 229 ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEA-ITVLL 287
E K A ER+ R LE++ + + E E K SKF + I L
Sbjct: 381 EMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLK 440
Query: 288 SWIERGEVNRRSANQFYSMVQSANS----HVRRLMNEKATHEQEME-------------E 330
+ + E + + + NS H+ L EQ E
Sbjct: 441 QELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE 500
Query: 331 AKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNA---Q 387
KE+F N T L + R D +RK I++ +K E L+ +
Sbjct: 501 EKESFLNKKTKQLQDLTEEKGTLAGEIRDMK-DMLEVKERK-INVLQKKIENLQEQLRDK 558
Query: 388 SEQLMGIRREEEMEMSDDENCDSPTKKMRV---DESALAAQAYALKEENDSLRWQ-LDAY 443
+QL ++ + +D N D+ + ++ + + +E +D R + ++++
Sbjct: 559 DKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESF 618
Query: 444 RNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKE 503
R E + LK++ L E K+ L L++ + L +L + + +EQ KE
Sbjct: 619 RKENKDLKEKVNAL--QAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKE 676
Query: 504 EQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLT-----------VALVNQDRE 552
E S L+ QLK + + + + E +++I L A DR
Sbjct: 677 ECSK-------LEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRL 729
Query: 553 NNIEKRSQGLKSEKEALLIGIIS-TFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLM 611
I K + K++K+ + + S T H+ + L + QQL+ K +A +E +
Sbjct: 730 LEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANL-KHNQQLEKKKNAQLLEEVRR 788
Query: 612 R 612
R
Sbjct: 789 R 789
Score = 34.3 bits (77), Expect = 0.36
Identities = 42/168 (25%), Positives = 76/168 (45%), Gaps = 32/168 (19%)
Query: 422 LAAQAYALKEENDSLRWQLD-------AYRNEVELL---KQEKEQLFRTEE----NLTKD 467
L AQ L+ END LR +LD + N ++ + +KE++ R EE ++ K+
Sbjct: 150 LQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKE 209
Query: 468 Q------QLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKG 521
Q + Q LQ T+Q +Q +L T Q +LN+ L+Q + +++ +E +
Sbjct: 210 QMRVSHEENQHLQLTIQALQDELRT-QRDLNHL---LQQESGNRGAEHFTIELTEENFR- 264
Query: 522 TKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEAL 569
+ E+ +L L ++ E IE + Q L + E++
Sbjct: 265 -----RLQAEHDRQAKELFLLRKTL--EEMELRIETQKQTLNARDESI 305
Score = 32.7 bits (73), Expect = 1.1
Identities = 50/275 (18%), Positives = 115/275 (41%), Gaps = 36/275 (13%)
Query: 257 AIMHYSEHEAALLAEKLKDDSKFS----------EAITVLLSWIERG---EVNRRSANQF 303
+++ EH ++L + LK DSK E + L + +++ E + R +F
Sbjct: 642 SLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEF 701
Query: 304 YSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWD 363
++ + +E + E++ E K + ++I + + + R
Sbjct: 702 ADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLR----- 756
Query: 364 HFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALA 423
H +K ++ KH+++L ++ QL+ R E M+D+ ++ ++++E
Sbjct: 757 HMKDQNKKVANL--KHNQQLEKKKNAQLLEEVRRREDSMADN------SQHLQIEE---- 804
Query: 424 AQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQ 483
L + R +LDA + + +Q + NL +++ Q L++ ++ Q+
Sbjct: 805 -----LMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQ-LEEILEMKQEA 858
Query: 484 LLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQ 518
LL E + + LE + ++ TQ + L+ +
Sbjct: 859 LLAAISEKDANIALLELSASKKKKTQEEVMALKRE 893
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 60.1 bits (144), Expect = 6e-09
Identities = 54/260 (20%), Positives = 108/260 (41%), Gaps = 10/260 (3%)
Query: 307 VQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFS 366
V+ VR + E +M E +E + Q EQ+ +Q+
Sbjct: 180 VREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQ 239
Query: 367 KAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQA 426
+ Q + + + EE Q EQ+ RE+E +M + E K+ E Q
Sbjct: 240 EEQVQKQEEQVQKQEEQMRKQEEQM----REQEEQMREQEEQMLKQKEQTEQEEQTGEQE 295
Query: 427 YALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLT 486
++E+ + +R Q + R + E +++++EQ+ + EE + + ++ + Q+ Q++ +
Sbjct: 296 EQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMG 355
Query: 487 IQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVAL 546
QEE K+ E + +EEQ Q +EQ++ +E + + E
Sbjct: 356 EQEEQMQKQEEQVRKQEEQMRKQ------EEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQ 409
Query: 547 VNQDRENNIEKRSQGLKSEK 566
+ + E E++ Q K E+
Sbjct: 410 MREQEEQMGEQKEQMRKQEE 429
Score = 58.2 bits (139), Expect = 2e-08
Identities = 44/203 (21%), Positives = 89/203 (43%), Gaps = 11/203 (5%)
Query: 307 VQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFS 366
VQ V++ + E++M E +E + +L Q EQ T Q+
Sbjct: 243 VQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQ--------TEQEEQTGEQ 294
Query: 367 KAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQA 426
+ Q + + + EE Q EQ+ R +EE +E ++M + + Q
Sbjct: 295 EEQMREQEEQMREQEEQMREQEEQM---REQEEQMGKQEEQMWEQKEQMWEQKEQMWKQE 351
Query: 427 YALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLT 486
+ E+ + ++ Q + R + E +++++EQ+ + EE + K ++ Q+ G Q++ +
Sbjct: 352 EQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMR 411
Query: 487 IQEELNNKKSELEQAKEEQSHTQ 509
QEE ++ E + +EE Q
Sbjct: 412 EQEEQMGEQKEQMRKQEEHMGEQ 434
Score = 49.7 bits (117), Expect = 8e-06
Identities = 35/184 (19%), Positives = 83/184 (45%), Gaps = 6/184 (3%)
Query: 384 RNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAY 443
+ Q + G RE+E +M + E +M E + Q ++++ + + Q +
Sbjct: 176 QEGQVREQEGQVREQEGQMGEQEG------QMGEQEEQMGEQEEQMQKQEEQMGEQEEQM 229
Query: 444 RNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKE 503
R + E + +++EQ+ + EE + K ++ Q+ Q++ + QEE K+ E + +E
Sbjct: 230 RKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEE 289
Query: 504 EQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLK 563
+ + ++ +EQ++ +E + + E + + +E E++ Q K
Sbjct: 290 QTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWK 349
Query: 564 SEKE 567
E++
Sbjct: 350 QEEQ 353
Score = 48.1 bits (113), Expect = 2e-05
Identities = 40/215 (18%), Positives = 94/215 (43%), Gaps = 23/215 (10%)
Query: 384 RNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAY 443
+ Q + G RE+E ++ + E ++R E + Q ++E+ + Q
Sbjct: 148 QEGQVREQEGQVREQEGQVREQEG------QVREQEGQVREQEGQVREQEGQMGEQEGQM 201
Query: 444 RNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKE 503
+ E + +++EQ+ + EE + + ++ Q+ G Q++ + QEE K+ E + +E
Sbjct: 202 GEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQE 261
Query: 504 EQSHTQ-ALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGL 562
EQ Q ++ +EQ+ KE E + E ++ + +++E + ++ + +
Sbjct: 262 EQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQM--REQEEQMREQEEQM 319
Query: 563 KSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQL 597
+ ++E + G E +W +Q+
Sbjct: 320 REQEEQM--------------GKQEEQMWEQKEQM 340
Score = 40.4 bits (93), Expect = 0.005
Identities = 40/186 (21%), Positives = 84/186 (45%), Gaps = 9/186 (4%)
Query: 384 RNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAY 443
+ Q + G RE+E ++ + E ++R E + Q ++E+ +R Q
Sbjct: 106 QEGQVREQEGQVREQEGQVREQEG------QVREQEGQVREQEGQVREQEGQVREQEGQV 159
Query: 444 RNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQ-GMQQQLLTIQEELNNKKSELEQAK 502
R + +++++ Q+ R +E ++Q+ Q +Q Q G Q+ + QEE ++ E Q +
Sbjct: 160 REQEGQVREQEGQV-REQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQ 218
Query: 503 EEQ-SHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQG 561
EEQ + ++ +EQ+ +E V+ + E + + E E+ Q
Sbjct: 219 EEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQM 278
Query: 562 LKSEKE 567
LK +++
Sbjct: 279 LKQKEQ 284
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 59.7 bits (143), Expect = 8e-09
Identities = 55/277 (19%), Positives = 122/277 (44%), Gaps = 28/277 (10%)
Query: 228 WECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLL 287
W+ ++RM ++ER R K E+R+R M E EK++++ K E
Sbjct: 503 WDQEERMWEQDERLREK--EERMREQKK---MWQQE-------EKMREEKKTQEQEKKTW 550
Query: 288 SWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
E+ R + M + +M E+ E++M+E +E + + Q E
Sbjct: 551 DQEEKMREEERMREREKKMREE-----EEMMREQ---EEKMQEQEEKMREQEEKMWEQEE 602
Query: 348 QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDEN 407
++ +K W+ K + + + EE+ Q E++ + +EE +E
Sbjct: 603 KM-----QEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKM---QEQEEKMWEQEEK 654
Query: 408 CDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKD 467
+KMR E + Q ++E+ + ++ Q + R + E ++ ++E+++ EE +
Sbjct: 655 MREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQ 714
Query: 468 QQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE 504
++ + Q+ M+ ++++ +E++ + E E+ E
Sbjct: 715 EEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSE 751
Score = 55.8 bits (133), Expect = 1e-07
Identities = 58/320 (18%), Positives = 138/320 (43%), Gaps = 20/320 (6%)
Query: 213 RLHVDFAQARDDFYEWECKQRM----RAREERHRRKLEEDRLRPPSPPAIMHYSEHEAAL 268
RL + R+ WE +++M R RE + + EE+ +R M E
Sbjct: 367 RLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEK--MQKQEENMWE 424
Query: 269 LAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSAN--SHVRRLMNEKATHEQ 326
EK + E L + E + Q + +++ ++ EQ
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 484
Query: 327 E--MEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
E M E +E ++ + Q E++ + R + + + Q+K K EE +
Sbjct: 485 EDQMWEQEEKMRDQEQKMWDQEERM---WEQDERLREKEERMREQKKMWQQEEKMREEKK 541
Query: 385 NAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYR 444
+ E+ ++E +M ++E KKMR +E + Q ++E+ + +R Q +
Sbjct: 542 TQEQEKKTW---DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMW 598
Query: 445 NEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE 504
+ E +++++E+++ EE + + ++ + MQ ++ + +E++ ++ ++ + +E+
Sbjct: 599 EQEEKMQEQEEKMWEQEEKMWEQEE----EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEK 654
Query: 505 QSHTQALLKVLQEQLKGTKE 524
+ ++ +E+++G +E
Sbjct: 655 MREQEEKMREQEEKMQGQEE 674
Score = 55.1 bits (131), Expect = 2e-07
Identities = 39/198 (19%), Positives = 95/198 (47%), Gaps = 9/198 (4%)
Query: 374 DIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEEN 433
++WR+ EELR EQ IR++EE +E KMR E + Q L+E+
Sbjct: 235 EMWRQE-EELR----EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQE 289
Query: 434 DSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNN 493
LR Q R + +L +QE++ + E+ ++++++ ++ M +++L ++++
Sbjct: 290 KELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE 349
Query: 494 KKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHED----SNEINVLTVALVNQ 549
++ ++ +E L+ +E+++ +++ E E+ E + +
Sbjct: 350 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMR 409
Query: 550 DRENNIEKRSQGLKSEKE 567
++E ++K+ + + ++E
Sbjct: 410 EQEEKMQKQEENMWEQEE 427
Score = 52.4 bits (124), Expect = 1e-06
Identities = 63/293 (21%), Positives = 130/293 (44%), Gaps = 30/293 (10%)
Query: 228 WECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLL 287
WE +++MR +EE+ R +E+RL E + +K++D E +
Sbjct: 320 WEQEEKMREQEEKMWR--QEERL---------WEQEKQMREQEQKMRDQ---EERMWEQD 365
Query: 288 SWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQE--MEEAKENFKNALTGILTQ 345
+ E R + + + R EK E+E M E +E + + Q
Sbjct: 366 ERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 425
Query: 346 FEQIVAVFN-ASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMG----IRREEEM 400
E+ ++K W+ K Q + IW + E++R+ E++ G + R+E+M
Sbjct: 426 EEKEWQQQRLPEQKEKLWEQ-EKMQEQEEKIW-EQEEKIRD--QEEMWGQEKKMWRQEKM 481
Query: 401 EMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQE----KEQ 456
+D+ + +KMR E + Q + E+++ LR + + R + ++ +QE +E+
Sbjct: 482 REQEDQMWEQ-EEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEK 540
Query: 457 LFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQ 509
+ +E T DQ+ + ++ +++ + +EE+ ++ E Q +EE+ Q
Sbjct: 541 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQ 593
Score = 50.4 bits (119), Expect = 5e-06
Identities = 49/238 (20%), Positives = 102/238 (42%), Gaps = 22/238 (9%)
Query: 317 LMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIW 376
L E E+E+ E ++ + + Q E++ + + + + Q K +
Sbjct: 232 LQEEMWRQEEELREQEKKIRKQEEKMWRQEERLR---EQEGKMREQEEKMRRQEKRL--- 285
Query: 377 RKHSEELRNAQSE--QLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEEND 434
R+ +ELR + E + +R +EE +E +KMR E + Q L E+
Sbjct: 286 REQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK 345
Query: 435 SLR-------------WQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQ 481
+R W+ D E E +E+E+++ EE + ++++++ ++ M+ +
Sbjct: 346 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMR-EE 404
Query: 482 QQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEI 539
++ + QEE K+ E +EE+ Q L +E+L +++ E E +I
Sbjct: 405 EETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 462
Score = 48.5 bits (114), Expect = 2e-05
Identities = 32/177 (18%), Positives = 87/177 (49%), Gaps = 5/177 (2%)
Query: 397 EEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQ 456
+EEM ++E + KK+R E + Q L+E+ +R Q + R + + L++++++
Sbjct: 233 QEEMWRQEEELREQE-KKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKE 291
Query: 457 LFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQ 516
L E+ L + ++L+ ++ MQ ++++ +E++ ++ ++ + +E + ++ +
Sbjct: 292 LREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE 351
Query: 517 EQLKGTKELV----ETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEAL 569
++++ +E + E E E + E I +R + ++ E+E +
Sbjct: 352 QKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETM 408
Score = 47.4 bits (111), Expect = 4e-05
Identities = 67/353 (18%), Positives = 147/353 (41%), Gaps = 35/353 (9%)
Query: 228 WECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKD-DSKFSEAITVL 286
WE +R+R +EER R E++++ + + E E++++ + K E +
Sbjct: 362 WEQDERLREKEERMR---EQEKM----------WEQEEKMQEEERIREREKKMREEEETM 408
Query: 287 LSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQF 346
E+ + ++ N + + EK +++M+E +E I Q
Sbjct: 409 REQEEK--MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ- 465
Query: 347 EQIVAVFNASTRQKA--------WDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGI--RR 396
E++ RQ+ W+ K + + +W + EE Q E+L R
Sbjct: 466 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ--EERMWEQDERLREKEERM 523
Query: 397 EEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQ 456
E+ +M E KK + E Q ++EE + +R + R E E++++++E+
Sbjct: 524 REQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREE-ERMREREKKMREEEEMMREQEEK 582
Query: 457 LFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQ 516
+ EE + + ++ + Q+ Q++ + QEE ++ E ++ +E++ + +Q
Sbjct: 583 MQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQ 642
Query: 517 EQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEAL 569
EQ + E E E E Q +E + ++ + ++ ++E +
Sbjct: 643 EQEEKMWEQEEKMREQEEKMREQEEKM-----QGQEEKMREQEEKMQGQEEKM 690
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 58.2 bits (139), Expect = 2e-08
Identities = 53/259 (20%), Positives = 119/259 (45%), Gaps = 13/259 (5%)
Query: 307 VQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFS 366
++ +R + E+++ E E + + Q E+I ++K W
Sbjct: 355 IREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQ-EEKRQEKMWRQEK 413
Query: 367 KAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQA 426
K + ++ I R+ EE+ + + IR EEM +E +KM+ +E + Q
Sbjct: 414 KMREQDEKI-REQEEEMWRQEEK----IRELEEMMQDQEEKLREVEEKMQEEEEKMQEQE 468
Query: 427 YALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQ-QTMQGMQQQLL 485
++ + + ++ Q + + +LLKQE E+++ EE + + ++ + Q + MQ ++++
Sbjct: 469 EKIQRQEEKIQEQEEKTWRQEKLLKQE-EKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQ 527
Query: 486 TIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVA 545
+E++ ++ L Q +E+ + L+ L+E+L + E G + +S + T+
Sbjct: 528 RQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLT 587
Query: 546 LVNQDRENNIEKRSQGLKS 564
+ Q +E +SQ +S
Sbjct: 588 PILQ-----VELKSQEAQS 601
Score = 55.5 bits (132), Expect = 2e-07
Identities = 50/273 (18%), Positives = 131/273 (47%), Gaps = 35/273 (12%)
Query: 314 VRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNI 373
+R + +EK+ + +++ K + A +L Q + V ++ +AQ +
Sbjct: 227 LRLVESEKSEIQLNVKDLKRKLERAQL-LLPQQQLQVEADRLGKELQSVSAKLQAQVEEN 285
Query: 374 DIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTK------KMRVDESALAAQAY 427
++W L N Q E+ M R+EE+++ +++ C+ K KM E + Q
Sbjct: 286 ELWN-----LLNQQQEEKMW-RQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEE 339
Query: 428 ALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL-TKDQQLQFLQQTM--------- 477
++E+ D + Q + R + E +++++E+++R EE + +D+++Q ++ M
Sbjct: 340 KIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE 399
Query: 478 --QGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKE-LVETNGHSHE 534
+ Q+++ ++++ + ++ + +EE + ++ L+E ++ +E L E E
Sbjct: 400 QEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQE 459
Query: 535 DSNEINVLTVALVNQDRENNIEKRSQGLKSEKE 567
+ ++ Q++E I+++ + ++ ++E
Sbjct: 460 EEEKM---------QEQEEKIQRQEEKIQEQEE 483
Score = 34.7 bits (78), Expect = 0.28
Identities = 54/262 (20%), Positives = 101/262 (38%), Gaps = 53/262 (20%)
Query: 228 WECKQRMRAREERHRRKL--EEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITV 285
W ++++R +EE+ + K+ +E ++R EK+++ +
Sbjct: 391 WRQEEKIREQEEKRQEKMWRQEKKMREQD----------------EKIREQEE------- 427
Query: 286 LLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQ 345
W + ++ + M+Q +R + + E++M+E +E I Q
Sbjct: 428 -EMWRQEEKI-----RELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEK-------IQRQ 474
Query: 346 FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDD 405
E+I +K W K ++ IW + EE Q E++ +EE +
Sbjct: 475 EEKI-----QEQEEKTWRQ-EKLLKQEEKIWEQ--EEKMWRQEEKMW---EQEEKMQEQE 523
Query: 406 ENCDSPTKKMRVDESALAAQAYALKEEN---DSLRWQLDAYRNEVELL-KQEKEQLFRTE 461
E +KMR E L Q ++E+ L +L + ELL +E +
Sbjct: 524 EKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRL 583
Query: 462 ENLTKDQQLQFLQQTMQGMQQQ 483
LT Q++ Q Q +QQQ
Sbjct: 584 PTLTPILQVELKSQEAQSLQQQ 605
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 58.2 bits (139), Expect = 2e-08
Identities = 53/259 (20%), Positives = 119/259 (45%), Gaps = 13/259 (5%)
Query: 307 VQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFS 366
++ +R + E+++ E E + + Q E+I ++K W
Sbjct: 355 IREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQ-EEKRQEKMWRQEK 413
Query: 367 KAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQA 426
K + ++ I R+ EE+ + + IR EEM +E +KM+ +E + Q
Sbjct: 414 KMREQDEKI-REQEEEMWRQEEK----IRELEEMMQDQEEKLREVEEKMQEEEEKMQEQE 468
Query: 427 YALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQ-QTMQGMQQQLL 485
++ + + ++ Q + + +LLKQE E+++ EE + + ++ + Q + MQ ++++
Sbjct: 469 EKIQRQEEKIQEQEEKTWRQEKLLKQE-EKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQ 527
Query: 486 TIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVA 545
+E++ ++ L Q +E+ + L+ L+E+L + E G + +S + T+
Sbjct: 528 RQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLT 587
Query: 546 LVNQDRENNIEKRSQGLKS 564
+ Q +E +SQ +S
Sbjct: 588 PILQ-----VELKSQEAQS 601
Score = 55.5 bits (132), Expect = 2e-07
Identities = 50/273 (18%), Positives = 131/273 (47%), Gaps = 35/273 (12%)
Query: 314 VRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNI 373
+R + +EK+ + +++ K + A +L Q + V ++ +AQ +
Sbjct: 227 LRLVESEKSEIQLNVKDLKRKLERAQL-LLPQQQLQVEADRLGKELQSVSAKLQAQVEEN 285
Query: 374 DIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTK------KMRVDESALAAQAY 427
++W L N Q E+ M R+EE+++ +++ C+ K KM E + Q
Sbjct: 286 ELWN-----LLNQQQEEKMW-RQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEE 339
Query: 428 ALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL-TKDQQLQFLQQTM--------- 477
++E+ D + Q + R + E +++++E+++R EE + +D+++Q ++ M
Sbjct: 340 KIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE 399
Query: 478 --QGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKE-LVETNGHSHE 534
+ Q+++ ++++ + ++ + +EE + ++ L+E ++ +E L E E
Sbjct: 400 QEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQE 459
Query: 535 DSNEINVLTVALVNQDRENNIEKRSQGLKSEKE 567
+ ++ Q++E I+++ + ++ ++E
Sbjct: 460 EEEKM---------QEQEEKIQRQEEKIQEQEE 483
Score = 34.7 bits (78), Expect = 0.28
Identities = 54/262 (20%), Positives = 101/262 (38%), Gaps = 53/262 (20%)
Query: 228 WECKQRMRAREERHRRKL--EEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITV 285
W ++++R +EE+ + K+ +E ++R EK+++ +
Sbjct: 391 WRQEEKIREQEEKRQEKMWRQEKKMREQD----------------EKIREQEE------- 427
Query: 286 LLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQ 345
W + ++ + M+Q +R + + E++M+E +E I Q
Sbjct: 428 -EMWRQEEKI-----RELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEK-------IQRQ 474
Query: 346 FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDD 405
E+I +K W K ++ IW + EE Q E++ +EE +
Sbjct: 475 EEKI-----QEQEEKTWRQ-EKLLKQEEKIWEQ--EEKMWRQEEKMW---EQEEKMQEQE 523
Query: 406 ENCDSPTKKMRVDESALAAQAYALKEEN---DSLRWQLDAYRNEVELL-KQEKEQLFRTE 461
E +KMR E L Q ++E+ L +L + ELL +E +
Sbjct: 524 EKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRL 583
Query: 462 ENLTKDQQLQFLQQTMQGMQQQ 483
LT Q++ Q Q +QQQ
Sbjct: 584 PTLTPILQVELKSQEAQSLQQQ 605
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 57.8 bits (138), Expect = 3e-08
Identities = 50/209 (23%), Positives = 92/209 (44%), Gaps = 28/209 (13%)
Query: 374 DIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEEN 433
++WR+ EELR EQ IR++EE +E KMR E + Q L+E+
Sbjct: 273 EMWRQE-EELR----EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQE 327
Query: 434 DSLRWQLDAYRNEVELLKQE-------------KEQLFRTEENLTKDQQLQFLQQTMQGM 480
LR Q R + EL +QE +E++ EE + + ++ + Q+
Sbjct: 328 KELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE 387
Query: 481 QQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
Q+Q + QEE ++ E + KEE+ Q + E+++ K++ E + + ++
Sbjct: 388 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM- 446
Query: 541 VLTVALVNQDRENNIEKRSQGLKSEKEAL 569
E I +R + ++ E+E +
Sbjct: 447 ---------QEEERIREREKKMREEEETM 466
Score = 57.0 bits (136), Expect = 5e-08
Identities = 61/361 (16%), Positives = 157/361 (43%), Gaps = 29/361 (8%)
Query: 228 WECKQRMRAREERHRRKLEE-DRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVL 286
WE +R+R +EER R + + +++ M E + EK++++ + E +
Sbjct: 400 WEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKM 459
Query: 287 LSWIE-----RGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTG 341
E ++ ++ N + + EK +++M+E +E
Sbjct: 460 REEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEK 519
Query: 342 ILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNA------QSEQLMGIR 395
I Q E +K W K + + +W + E++R+ Q E++
Sbjct: 520 IRDQEEMW------GQEKKMWRQ-EKMREQEDQMWEQE-EKMRDQEQKMWDQEERMEKKT 571
Query: 396 REEEME-------MSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVE 448
+E+E + M ++E KKMR +E + Q ++E+ + ++ Q + + E
Sbjct: 572 QEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEE 631
Query: 449 LLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHT 508
+++++E+++ EE + + ++ + QQ + +++L + E ++ ++++ +E+
Sbjct: 632 KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLW--EHEKMQEQEKMQEQEEKIWEQ 689
Query: 509 QALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
+ + K QEQ K T + + E + + +++E ++++ + ++ ++E
Sbjct: 690 EKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEE 749
Query: 569 L 569
+
Sbjct: 750 M 750
Score = 53.1 bits (126), Expect = 8e-07
Identities = 63/385 (16%), Positives = 154/385 (40%), Gaps = 56/385 (14%)
Query: 228 WECKQRMRAREER----------HRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDS 277
WE +++MR +EE+ +++ E + M + E++++
Sbjct: 358 WEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQE 417
Query: 278 KFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKN 337
K E + + + E +++ +Q M + +R + E+ M E +E +
Sbjct: 418 KMWEQVEKMREEKKMQEQEKKTRDQEEKMQE--EERIREREKKMREEEETMREQEEKMQK 475
Query: 338 ALTGILTQFEQIVAVFN-ASTRQKAWDHFSKAQRKNIDIWRK------------------ 378
+ Q E+ ++K W+ K Q + IW +
Sbjct: 476 QEENMWEQEEKEWQQQRLPEQKEKLWEQ-EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMW 534
Query: 379 HSEELRNAQS---EQLMGIRREEEMEMSDDENCDSPT-----------KKMRVDESALAA 424
E++R + EQ +R +E+ +E + T +KMR +E +
Sbjct: 535 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMR-EEERMRE 593
Query: 425 QAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQL 484
+ ++EE + +R Q + + + E +++++E+++ EE + + ++ + Q+ Q++
Sbjct: 594 REKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEK 653
Query: 485 LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTV 544
+ Q+ L +K +L + ++ Q QE+++ +E + + + E T
Sbjct: 654 MWEQQRLPEQKEKLWEHEKMQE---------QEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
Query: 545 ALVNQDRENNIEKRSQGLKSEKEAL 569
E ++ +R + ++ E+E +
Sbjct: 705 DQEKMREEESMREREKKMREEEEMM 729
Score = 48.5 bits (114), Expect = 2e-05
Identities = 61/336 (18%), Positives = 141/336 (41%), Gaps = 49/336 (14%)
Query: 228 WECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLL 287
WE +++MR +E++ +E+R+ + + E EK++++ + E +
Sbjct: 547 WEQEEKMRDQEQKMWD--QEERMEKKTQEQEKKTWDQE-----EKMREEERMREREKKMR 599
Query: 288 SWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
E E+ R + + ++ + E++M+E +E + Q E
Sbjct: 600 ---EEEEMMREQEEKMQEQEEKMQEQEEKMWEQ----EEKMQEQEEKMWEQEEKMWEQEE 652
Query: 348 QIVAVFNA-STRQKAWDHFS-----KAQRKNIDIWRKHS---------------EELRNA 386
++ ++K W+H K Q + IW + E++R
Sbjct: 653 KMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREE 712
Query: 387 QS--EQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYR 444
+S E+ +R EEEM +E +KM+ E + Q + E+ + + W+
Sbjct: 713 ESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM-WEQQRLP 771
Query: 445 NEVELL-----KQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELE 499
+ E L QE+E+++ EE + +DQ ++ M+G ++++ +E++ ++ ++
Sbjct: 772 EQKEKLWEHEKMQEQEKIWEQEEKM-RDQ-----EEKMRGQEEKMRGQEEKMRGQEEKMW 825
Query: 500 QAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHED 535
+E+ + + +E++ G +E +E E+
Sbjct: 826 GQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEE 861
Score = 47.4 bits (111), Expect = 4e-05
Identities = 51/310 (16%), Positives = 136/310 (43%), Gaps = 28/310 (9%)
Query: 228 WECKQRMRAREE---RHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAIT 284
WE ++++R +EE + ++ ++++R M E + +K+ D + E T
Sbjct: 514 WEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQ--MWEQEEKMRDQEQKMWDQEERMEKKT 571
Query: 285 VLLSWIERGEVNRRSANQFYSMVQSANSHVR-RLMNEKAT----HEQEMEEAKENFKNAL 339
E +++ +Q M + R + M E+ E++M+E +E +
Sbjct: 572 Q--------EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 623
Query: 340 TGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEE 399
+ Q E++ +K W+ K + +W + + + + ++ +E+
Sbjct: 624 EKMWEQEEKM-----QEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 678
Query: 400 MEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFR 459
M+ +++ + + + E E +S+R + R E E++++++E++
Sbjct: 679 MQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQE 738
Query: 460 TEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSEL---EQAKEEQS--HTQALLKV 514
EE + + ++ + Q+ Q++ + Q+ L +K +L E+ +E++ + ++
Sbjct: 739 QEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRD 798
Query: 515 LQEQLKGTKE 524
+E+++G +E
Sbjct: 799 QEEKMRGQEE 808
Score = 45.1 bits (105), Expect = 2e-04
Identities = 36/175 (20%), Positives = 78/175 (44%), Gaps = 4/175 (2%)
Query: 369 QRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYA 428
++K + + +E EQ +R +EE +E K+MR E + Q
Sbjct: 339 EQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER 398
Query: 429 LKEENDSLRWQLDAYRNEVELLKQ----EKEQLFRTEENLTKDQQLQFLQQTMQGMQQQL 484
+ E+++ LR + + R + ++ +Q +E+ + +E T+DQ+ + ++ +++
Sbjct: 399 MWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKK 458
Query: 485 LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEI 539
+ +EE ++ E Q +EE Q + Q++L KE + E +I
Sbjct: 459 MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513
Score = 42.7 bits (99), Expect = 0.001
Identities = 23/128 (17%), Positives = 70/128 (54%), Gaps = 1/128 (0%)
Query: 397 EEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQ 456
+EEM ++E + KK+R E + Q L+E+ +R Q + + + L++++++
Sbjct: 271 QEEMWRQEEELREQE-KKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKE 329
Query: 457 LFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQ 516
L E+ L + ++L+ ++ MQ ++++ +E++ ++ ++ + +E + ++ +
Sbjct: 330 LREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE 389
Query: 517 EQLKGTKE 524
++++ +E
Sbjct: 390 QKMRDQEE 397
Score = 41.2 bits (95), Expect = 0.003
Identities = 49/279 (17%), Positives = 116/279 (41%), Gaps = 38/279 (13%)
Query: 228 WECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLL 287
WE +++M +EE+ E+ RL P EHE EK+++ +
Sbjct: 641 WEQEEKMWEQEEK---MWEQQRL----PEQKEKLWEHEKMQEQEKMQEQEE--------K 685
Query: 288 SWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
W E+ ++ +++ Q M E+ E++M E +E + + Q E
Sbjct: 686 IW-EQEKMEKKTQEQEKKTWDQEKMREEESMRER---EKKMREEEEMMREQEEKMQEQEE 741
Query: 348 QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEM--SDD 405
++ ++ W+ K + +W ++ Q E+L + +E E +
Sbjct: 742 KM-----QEQEEEMWEQEEKMWEQEEKMWE---QQRLPEQKEKLWEHEKMQEQEKIWEQE 793
Query: 406 ENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLT 465
E +KMR E + Q ++ + + + Q + + E + ++E+++ EE
Sbjct: 794 EKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEK-- 851
Query: 466 KDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE 504
+++ MQG ++++ +E++ ++ ++ + +E+
Sbjct: 852 -------MEEKMQGQEEKMREQEEKMRGQEEKMREQEEK 883
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 57.0 bits (136), Expect = 5e-08
Identities = 88/422 (20%), Positives = 168/422 (39%), Gaps = 36/422 (8%)
Query: 163 EQCGDITAIRKSKKNFCHIRFAEEFMVDK-AIYLSGYRMRLGSSTDKKDSGRLHVDFAQA 221
EQ A +K K + R+ EE ++ A+ L YR + K+ + +L Q
Sbjct: 166 EQALSAVATQKKKAD----RYIEELTKERDALSLELYRNTITDEELKEKNAKL-----QE 216
Query: 222 RDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEH---EAALLAEKLKDDSK 278
+ E E K ++ + +RKLE +L P + ++H E ++ KL+ +
Sbjct: 217 KLQLVESE-KSEIQLNVKELKRKLERAKLLLPQQQ-LQAEADHLGKELQSVSAKLQAQVE 274
Query: 279 FSEAITVLLS------WIERGEVNRRSAN--QFYSMVQSANSHVRRL------MNEKATH 324
+E L W + ++ R + ++ +RR EK
Sbjct: 275 ENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRR 334
Query: 325 EQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
++EM KE L + + E+I ++ K Q + +WR+ E++R
Sbjct: 335 QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE-EKIR 393
Query: 385 NAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYR 444
EQ IR +EEM +E +KM E + Q ++ + + +R Q R
Sbjct: 394 ----EQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIR 449
Query: 445 NEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE 504
+ E +++++E + EE + + + Q+ Q++ + QEE ++ + + +EE
Sbjct: 450 EQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEE 509
Query: 505 QSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKS 564
+ Q +++QEQ + E E E E + RE + R Q K
Sbjct: 510 KIREQE--EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKM 567
Query: 565 EK 566
++
Sbjct: 568 QE 569
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 56.6 bits (135), Expect = 7e-08
Identities = 48/181 (26%), Positives = 90/181 (49%), Gaps = 20/181 (11%)
Query: 355 ASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKK 414
AS R K S+ Q+K +D+ R+ R +Q EQ+ R+EEE+ + +
Sbjct: 1309 ASLRAK----LSEEQKKQVDLERE-----RASQEEQIA--RKEEELSRVKERVVQQEVVR 1357
Query: 415 MRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQ----- 469
+E L A+A A E D Q+D R E+ L++ + +L R E L +++Q
Sbjct: 1358 YE-EEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREA 1416
Query: 470 ---LQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELV 526
+Q LQQ + ++Q+ +E++ + + + Q +Q+ ALL++ E+ + ++L+
Sbjct: 1417 EREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLL 1476
Query: 527 E 527
E
Sbjct: 1477 E 1477
Score = 44.3 bits (103), Expect = 4e-04
Identities = 85/358 (23%), Positives = 141/358 (39%), Gaps = 59/358 (16%)
Query: 232 QRMRAREERHRRKLEEDRLRPPS---PPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
+R RA +E + EE+ R ++ Y E E L AE S F+E+I V L
Sbjct: 1326 ERERASQEEQIARKEEELSRVKERVVQQEVVRYEE-EPGLRAEA----SAFAESIDVELR 1380
Query: 289 WIE--RGEVNR--RSANQFYSMVQS----------ANSHVRRLMNEKATHEQEMEEAKEN 334
I+ R E+ R R + ++ A V+RL A EQE EA+E
Sbjct: 1381 QIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREK 1440
Query: 335 FKNALTGILTQFEQIV---AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL 391
+ +L Q Q A+ ++ H + ++ R+ L A+ ++
Sbjct: 1441 VTHTQKVVLQQDPQQAREHALLRLQLEEE--QHRRQLLEGELETLRRKLAALEKAEVKEK 1498
Query: 392 MGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVEL-- 449
+ + ++E D E K +ES K E D +L+A +E+E
Sbjct: 1499 VVLSESVQVEKGDTEQEIQRLKSSLEEES-------RSKRELDVEVSRLEARLSELEFHN 1551
Query: 450 LKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAK-----EE 504
K KE F EEN LQ Q +Q + +Q E+N +E + +
Sbjct: 1552 SKSSKELDFLREEN-------HKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADS 1604
Query: 505 QSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVL-----TVALVNQDRENNIEK 557
++ + L L+ +L K L S + EI+ L +VA+ + REN++ +
Sbjct: 1605 GTNHDSRLWSLERELDDLKRL------SKDKDLEIDELQKRLGSVAVKREQRENHLRR 1656
Score = 39.7 bits (91), Expect = 0.009
Identities = 56/233 (24%), Positives = 105/233 (45%), Gaps = 26/233 (11%)
Query: 314 VRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWD-----HFSKA 368
+R+ ++E+ +++E ++ + + + Q Q +V +K D F +
Sbjct: 895 IRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQ-ESVVRKEVLKKVPDPVLEESFQQL 953
Query: 369 QRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVD-ESALAAQAY 427
QR + +H +L + E L R E E D + +R++ + A A +
Sbjct: 954 QRTLAE--EQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVL 1011
Query: 428 ALKEENDSLRWQLDAYRNEVELLKQE----KEQLFRTEENLTK--------DQQL----Q 471
L+EE ++LR Q A EV LL+Q E+ R +E +T+ D QL Q
Sbjct: 1012 QLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQ 1071
Query: 472 FLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKE 524
LQ+ Q Q +EEL+ + +L++ ++E++ + + V +E LK K+
Sbjct: 1072 QLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITV-KEVLKVEKD 1123
Score = 30.8 bits (68), Expect = 4.0
Identities = 40/226 (17%), Positives = 95/226 (42%), Gaps = 28/226 (12%)
Query: 305 SMVQSANSHVRRLMNEKATHEQEMEEAKEN---FKNALTGILTQFEQIVAVFNASTRQKA 361
S +++ + + L++E A+ EQE+++ N ++ A+ + E++ ++ + + +
Sbjct: 761 SQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSS 820
Query: 362 WDHFSKAQRKNIDIWR-KHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDES 420
H SK R + K E A+ ++ I R+ + N ++ V
Sbjct: 821 --HVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHE 878
Query: 421 AL--------AAQAYALKEENDSLRWQLDAYRNEVELLKQE--------------KEQLF 458
L +A+ +++E D + NEV+ ++E ++++
Sbjct: 879 TLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVL 938
Query: 459 RTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE 504
+ + ++ Q LQ+T+ Q + +QEEL + +L ++E
Sbjct: 939 KKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQE 984
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 55.5 bits (132), Expect = 2e-07
Identities = 58/239 (24%), Positives = 102/239 (42%), Gaps = 38/239 (15%)
Query: 359 QKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRRE----EEMEMSDDENCDSPTKK 414
Q + F Q+ ID + E+ + +Q I + +E +++ C S
Sbjct: 22 QNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQS---- 77
Query: 415 MRVDESALAAQAYALKEENDSLRWQLDA-------YRNEVELLKQEKEQLFRTEENLTKD 467
+R++ L Q AL E+N L D + E L+ EK L RT E L+
Sbjct: 78 LRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLS-- 135
Query: 468 QQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVE 527
Q+L++L + ++ + ++L +E N K EL+ +E + +K +++L+ KEL+
Sbjct: 136 QELEYLTEDVKRLNEKL----KESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLH 191
Query: 528 TNGH----------------SHEDSNEINVLTVALVNQDRE-NNIEKRSQGLKSEKEAL 569
+ E NEI L L N+ E + +E++ GLK+ E L
Sbjct: 192 SQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHL 250
Score = 40.8 bits (94), Expect = 0.004
Identities = 77/368 (20%), Positives = 154/368 (41%), Gaps = 68/368 (18%)
Query: 232 QRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEK--LKDDSKFSEAITVLLSW 289
Q+M+A+ RKLE D L P A SE L AEK L++D K +A
Sbjct: 1291 QQMQAKV----RKLELDIL--PLQEANAELSEKSGMLQAEKKLLEEDVKRWKA------- 1337
Query: 290 IERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQI 349
R+ + R+L++EK H + +++ LT + + +
Sbjct: 1338 --------RNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQ--------LTEEIGRLKAE 1381
Query: 350 VAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCD 409
+A NAS + ++ +++++ R E ++ +++ I+ + +
Sbjct: 1382 IARSNASLTNN--QNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEK----VKTITQVK 1435
Query: 410 SPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTE-ENLTKDQ 468
++ + L AQ + E + V+ +++ KE L + E ++ + +
Sbjct: 1436 KIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLES 1495
Query: 469 QLQFLQQTM-------QGMQQQLLTIQEELNNKKSELEQ--AKEEQSHTQ---------- 509
Q++ LQ+T+ + +Q+Q + +Q EL+ + +L+ +EEQ Q
Sbjct: 1496 QVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRK 1555
Query: 510 ---------ALLKVLQEQL-KGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRS 559
A L +++QL K +EL + NG + +E++V AL +Q E I +
Sbjct: 1556 AIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQ-YEGRISRLE 1614
Query: 560 QGLKSEKE 567
+ L+ +E
Sbjct: 1615 RELREHQE 1622
Score = 36.6 bits (83), Expect = 0.073
Identities = 64/340 (18%), Positives = 133/340 (39%), Gaps = 52/340 (15%)
Query: 271 EKLKDDS--KFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEM 328
EK++++ K E +T L S + A++ Y M+Q RR + Q++
Sbjct: 690 EKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKL 749
Query: 329 E---EAKENFKNALTGILTQFEQIVAVFNAST----RQKAWDHFSK---AQRKNIDIWRK 378
+ +E N +T L + +AV ++K S+ +Q++ + +
Sbjct: 750 TATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQ 809
Query: 379 HSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRW 438
+ L + + GI E E + S +K+ + S L + E+ +L
Sbjct: 810 RGQNLLLTNLQTIQGILERSETETK--QRLSSQIEKLEHEISHLKKKLENEVEQRHTLTR 867
Query: 439 QLDA---------------YRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQ----- 478
LD + N ELLK ++++ +++L+ + ++Q Q+ Q
Sbjct: 868 NLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLS-NMEVQVASQSSQRTGKG 926
Query: 479 ---------GMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETN 529
+ QL +E++N+ K L+ + QA++ L+E L K++ E
Sbjct: 927 QPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTE-- 984
Query: 530 GHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEAL 569
N+ + + + +EK+ ++ EK+ L
Sbjct: 985 ------EVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQEL 1018
Score = 36.2 bits (82), Expect = 0.096
Identities = 47/227 (20%), Positives = 102/227 (44%), Gaps = 26/227 (11%)
Query: 299 SANQFYSMVQSANSHVRRLMNEKATHE-QEMEEAKENFKNALTGILTQFEQI-------V 350
S Q++ + + + RL+NE T E Q + E N L + + +++ +
Sbjct: 50 SEQQYFEIEKRLSHSQERLVNE--TRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNI 107
Query: 351 AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR---------NAQSEQLMGIRREEEME 401
A+ + TR K + +R I + S+EL N + ++ + E +++
Sbjct: 108 AIQSQFTRTK--EELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLK 165
Query: 402 MSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEK-EQLFRT 460
+ + + D K E L + L +N L +L +E+ L +EK ++
Sbjct: 166 LDELQASDVSVKYR---EKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILEL 222
Query: 461 EENL-TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQS 506
+ NL K +++ L++ M G++ +Q+ + + ++L++AKE+Q+
Sbjct: 223 KCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQA 269
Score = 36.2 bits (82), Expect = 0.096
Identities = 55/269 (20%), Positives = 113/269 (42%), Gaps = 31/269 (11%)
Query: 263 EHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKA 322
EHE + L +KL+++ + +R + R Q + ++ +N K
Sbjct: 845 EHEISHLKKKLENEVE------------QRHTLTRNLDVQLLDTKRQLDTETNLHLNTKE 892
Query: 323 ---THEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKH 379
++E+ K++ N + +Q Q S ++ D S+ ++ +
Sbjct: 893 LLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQV---- 948
Query: 380 SEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
+L+ + + + M S +E+ + K+ +V E LKE + + Q
Sbjct: 949 -NDLKERLKTSTSNVEQYQAMVTSLEESLN---KEKQVTEEVRKNIEVRLKESAE-FQTQ 1003
Query: 440 LDAYRNEVELLKQE-KEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSEL 498
L+ EVE KQE ++ R E++ +QQL L++T+ +Q + +QE L + L
Sbjct: 1004 LEKKLMEVEKEKQELQDDKRRAIESM--EQQLSELKKTLSSVQNE---VQEALQRASTAL 1058
Query: 499 EQAKEEQSHTQALLKV-LQEQLKGTKELV 526
++ + Q K+ ++ Q K +EL+
Sbjct: 1059 SNEQQARRDCQEQAKIAVEAQNKYERELM 1087
Score = 33.9 bits (76), Expect = 0.48
Identities = 36/150 (24%), Positives = 69/150 (46%), Gaps = 6/150 (4%)
Query: 380 SEELRNAQS--EQLMGIRREEEMEMSDDE--NCDSPTKKMRVD--ESALAAQAYALKEEN 433
SEE ++ + E L IRRE+E+ + E +S + RV+ E L +L E
Sbjct: 1187 SEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAER 1246
Query: 434 DSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNN 493
+ ++ EL+K+ + E N ++ + L+Q +Q MQ ++ ++ ++
Sbjct: 1247 EKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILP 1306
Query: 494 KKSELEQAKEEQSHTQALLKVLQEQLKGTK 523
+ + E+ QA K+L+E +K K
Sbjct: 1307 LQEANAELSEKSGMLQAEKKLLEEDVKRWK 1336
Score = 33.1 bits (74), Expect = 0.81
Identities = 43/218 (19%), Positives = 90/218 (41%), Gaps = 13/218 (5%)
Query: 291 ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFK-NALTGILTQFEQI 349
E GE N+ + + QS + + ++ + E+E+E A + G + E++
Sbjct: 316 EAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEEL 375
Query: 350 VAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEM-EMSDDENC 408
A+ S A K K +++ + E E+L R + + E+ +
Sbjct: 376 AAM---SPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEA 432
Query: 409 DSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQ 468
+P K + +E A +A A SL +L+ E++ L+++ ++ + L +D
Sbjct: 433 KAPILKRQREEYERAQKAVA------SLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDN 486
Query: 469 QLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQS 506
+ +Q ++ + QQ+ + EL + EE S
Sbjct: 487 RRMEIQ--VKDLSQQIRVLLMELEEARGNHVIRDEEVS 522
Score = 32.7 bits (73), Expect = 1.1
Identities = 34/134 (25%), Positives = 53/134 (39%), Gaps = 4/134 (2%)
Query: 439 QLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSEL 498
++D + E K E EQ + E Q + + +T + Q L E+LNN+ L
Sbjct: 35 EIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETREC--QSLRLELEKLNNQLKAL 92
Query: 499 EQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQD--RENNIE 556
+ +E Q +Q Q TKE +E +NE + + +D R N
Sbjct: 93 TEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKL 152
Query: 557 KRSQGLKSEKEALL 570
K S K E + L
Sbjct: 153 KESNTTKGELQLKL 166
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 55.1 bits (131), Expect = 2e-07
Identities = 69/347 (19%), Positives = 150/347 (43%), Gaps = 33/347 (9%)
Query: 229 ECKQRMRAREERHRRKLEEDR--LRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVL 286
+ ++R+R REE+ R++LE+ R L S +E +A + AE +K E +
Sbjct: 1031 DLEERLR-REEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI-AELKMQLAKKEEELQAA 1088
Query: 287 LSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQF 346
L+ +E + A + ++S S ++ + + + E+ K + L + T+
Sbjct: 1089 LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTEL 1148
Query: 347 EQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDE 406
E + A + + ++I +K EE Q+ +R++ + +
Sbjct: 1149 EDTL------DSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELA 1202
Query: 407 NCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEK---EQLFRTEEN 463
TK+++ + L++ +L + NEV++L Q K E + E
Sbjct: 1203 EQLEQTKRVKAN----------LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEA 1252
Query: 464 LTKDQQLQFLQ--QTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKG 521
++ Q++F + + + ++ +Q EL+N L Q+ + S L+ QL+
Sbjct: 1253 QLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQD 1312
Query: 522 TKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
T+EL++ E+ ++++ T +D +N+ ++ L+ E+EA
Sbjct: 1313 TQELLQ-----EENRQKLSLSTKLKQVEDEKNSFREQ---LEEEEEA 1351
Score = 47.0 bits (110), Expect = 5e-05
Identities = 40/138 (28%), Positives = 71/138 (51%), Gaps = 10/138 (7%)
Query: 381 EELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQL 440
EEL + +QL R EME + +K+++ E A L E + LR +L
Sbjct: 852 EELVKVREKQLAAENRLTEMETLQSQLM---AEKLQLQEQLQAETE--LCAEAEELRARL 906
Query: 441 DAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQ 500
A + E+E + + E R EE ++++ Q LQ + MQQ + ++E+L ++S ++
Sbjct: 907 TAKKQELEEICHDLEA--RVEE---EEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK 961
Query: 501 AKEEQSHTQALLKVLQEQ 518
+ E+ T+A LK L+E+
Sbjct: 962 LQLEKVTTEAKLKKLEEE 979
Score = 46.2 bits (108), Expect = 9e-05
Identities = 84/361 (23%), Positives = 143/361 (39%), Gaps = 79/361 (21%)
Query: 220 QARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKF 279
Q RD+ E + KQ +R E +LE++R + A +KL+ D K
Sbjct: 1574 QGRDEQSEEKKKQLVRQVREMEA-ELEDERKQ-----------RSMAVAARKKLEMDLKD 1621
Query: 280 SEAITVLLSWIERGEVNRRSA-NQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKN- 337
EA I+ NR A Q + +R L + +A+ E+ + +AKEN K
Sbjct: 1622 LEA------HIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKL 1675
Query: 338 -ALTGILTQFEQIVAVFNASTRQ------KAWDHFSKAQRKN-IDIWRKHSEELRNAQSE 389
++ + Q ++ +A + RQ + D + + K + + K E R AQ E
Sbjct: 1676 KSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLE 1735
Query: 390 QLMGIRREEEMEMSDDENCDSPTKKM-----RVDESALAAQAYALKEENDSLRWQLDAYR 444
+ E E E + E + KK +++ +++A K EN R QL+
Sbjct: 1736 E------ELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNEN--ARQQLERQN 1787
Query: 445 NEVELLKQEKE-------------------QLFRTEENLTKDQQLQFLQ--QTMQGMQQQ 483
E+++ QE E QL +N TK++Q Q +T + ++
Sbjct: 1788 KELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDV 1847
Query: 484 LLTIQEELNNK-----------------KSELEQAKEEQSHTQALLKVLQEQLKGTKELV 526
LL + +E N K +LE+A+EE A + LQ +L+ E
Sbjct: 1848 LLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETA 1907
Query: 527 E 527
+
Sbjct: 1908 D 1908
Score = 45.1 bits (105), Expect = 2e-04
Identities = 65/303 (21%), Positives = 127/303 (41%), Gaps = 45/303 (14%)
Query: 297 RRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKE--------NFKNALTGILTQFEQ 348
+++ + ++ S ++L EK T E ++++ +E N K A L E
Sbjct: 942 QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKL--LED 999
Query: 349 IVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENC 408
+A F + ++ S A+ KN KH + + + +RREE+ +
Sbjct: 1000 RIAEFTTNLTEEEEKSKSLAKLKN-----KHEAMITDLEER----LRREEKQR----QEL 1046
Query: 409 DSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVEL-LKQEKEQLFRTEENLTK- 466
+ +K+ D + L+ Q L+ + L+ QL E++ L + +E+ + L K
Sbjct: 1047 EKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKI 1106
Query: 467 ---DQQLQFLQQTMQG-------MQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQ 516
+ Q+ LQ+ ++ ++Q + EEL K+ELE + + Q L +
Sbjct: 1107 RELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE 1166
Query: 517 EQLKGTKELVETNGHSHE---------DSNEINVLTVALVNQDR-ENNIEKRSQGLKSEK 566
+++ K+ +E +HE S + L L R + N+EK Q L++E+
Sbjct: 1167 QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENER 1226
Query: 567 EAL 569
L
Sbjct: 1227 GEL 1229
Score = 43.5 bits (101), Expect = 6e-04
Identities = 72/359 (20%), Positives = 146/359 (40%), Gaps = 45/359 (12%)
Query: 242 RRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSAN 301
+++ + D+L Y+E AE + ++K L +E+ R
Sbjct: 1441 KKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNK 1500
Query: 302 QFYSMVQSANSH-------VRRLMNEKATHEQEMEEAK------ENFKNALTGILTQFEQ 348
QF + ++ S V L K EQ++EE K E+ A + E
Sbjct: 1501 QFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEV 1560
Query: 349 IVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSE---ELRNAQSEQLMGIRREEEMEM--- 402
+ A + +++ K + R+ E EL + + ++ M + +++EM
Sbjct: 1561 NLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLK 1620
Query: 403 -------SDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKE 455
S ++N D K++R L AQ E D R A R E+ +E E
Sbjct: 1621 DLEAHIDSANKNRDEAIKQLR----KLQAQMKDCMRELDDTR----ASREEILAQAKENE 1672
Query: 456 QLFRT--EENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLK 513
+ ++ E + ++L ++ + QQ+ + +E+ N + A EE+ +A +
Sbjct: 1673 KKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIA 1732
Query: 514 VLQEQL---KGTKELV-----ETNGHSHEDSNEINV-LTVALVNQDRENNIEKRSQGLK 563
L+E+L +G EL+ + N + + ++N+ + A N++ +E++++ LK
Sbjct: 1733 QLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELK 1791
Score = 40.0 bits (92), Expect = 0.007
Identities = 63/340 (18%), Positives = 151/340 (44%), Gaps = 43/340 (12%)
Query: 263 EHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKA 322
++ LL++ SK ++ + L S ++ + + N+ S ++ ++++ +EK
Sbjct: 1283 DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR---QKLSLSTKLKQVEDEKN 1339
Query: 323 THEQEMEEAKENFKNALTGILTQFEQIVAV-----FNASTRQKAWDHFSKAQRKNIDIWR 377
+ +++EE +E N I T Q+ + + + A + K Q+ + +
Sbjct: 1340 SFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQ 1399
Query: 378 KHSEELRNAQSEQLMGIRREEEMEMSD---------DENCDSPTKKMRVDESALAAQAYA 428
+H E++ A ++L + + E+ D C+ K+ + D+ + +
Sbjct: 1400 RHEEKV--AAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTIS 1457
Query: 429 LKEENDSLRWQLDAYRNEVELL------------KQEKEQL---FRTE-ENL--TKD--- 467
K + R + +A E + L K E E+L FRTE E+L +KD
Sbjct: 1458 AKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVG 1517
Query: 468 QQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVE 527
+ + L+++ + ++QQ+ ++ +L + EL+ ++ + + L+ ++ Q + ++L
Sbjct: 1518 KSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE--RDLQG 1575
Query: 528 TNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKE 567
+ S E ++ V V + + E+ ++RS + + K+
Sbjct: 1576 RDEQSEEKKKQL-VRQVREMEAELEDERKQRSMAVAARKK 1614
Score = 38.5 bits (88), Expect = 0.019
Identities = 42/172 (24%), Positives = 82/172 (47%), Gaps = 20/172 (11%)
Query: 380 SEELR---NAQSEQLMGIRREEEMEMSDDE----NCDSPTKKMRVDESALAAQAYALKEE 432
+EELR A+ ++L I + E + ++E + + KKM+ + L Q +EE
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE--EEE 956
Query: 433 NDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELN 492
+ + QL+ E +L K E+EQ+ ++N ++ + L+ + LT +EE +
Sbjct: 957 SARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTN-LTEEEEKS 1015
Query: 493 NKKSELEQAKEEQSHTQALLKVLQEQL----KGTKELVETNGHSHEDSNEIN 540
++L+ E A++ L+E+L K +EL +T DS +++
Sbjct: 1016 KSLAKLKNKHE------AMITDLEERLRREEKQRQELEKTRRKLEGDSTDLS 1061
Score = 37.0 bits (84), Expect = 0.056
Identities = 36/160 (22%), Positives = 63/160 (39%), Gaps = 28/160 (17%)
Query: 440 LDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEE--------- 490
L R E E++ +E+E + E+ L + +L ++ + + L +QE+
Sbjct: 838 LQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCA 897
Query: 491 --------LNNKKSEL-----------EQAKEEQSHTQALLKVLQEQLKGTKELVETNGH 531
L KK EL E+ +E H QA K +Q+ ++ +E +E
Sbjct: 898 EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEES 957
Query: 532 SHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEALLI 571
+ + V T A + + E I Q K KE L+
Sbjct: 958 ARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLL 997
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 55.1 bits (131), Expect = 2e-07
Identities = 77/387 (19%), Positives = 162/387 (41%), Gaps = 49/387 (12%)
Query: 232 QRMRAREERH-------RRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKD---DSKFSE 281
QR+ A ER R+ LEE LR + ++ + L E L+ +K +E
Sbjct: 268 QRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATE 327
Query: 282 AITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHE---------QEMEEAK 332
+ E++ + NS +R M+ + + Q + E K
Sbjct: 328 EDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMK 387
Query: 333 ENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLM 392
++ +++ L E+ + + ++ + + + K ++++R HS+ ++N +
Sbjct: 388 DSKISSMERGLRDLEEEIQMLKSNGALSTEER--EEEMKQMEVYRSHSKFMKNKIGQVKQ 445
Query: 393 GIRREE--------EMEMSDDENCDSPTKKMRVDESALAAQAYA--LKEENDSLRWQLDA 442
+ R++ ++E ++ DS + ES A + A L+ E D+LR +L+
Sbjct: 446 ELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE- 504
Query: 443 YRNEVELLKQEKEQLFRTEENLT--------------KDQQLQFLQQTMQGMQQQLLTIQ 488
E L K+ K+ EE T K++++ LQ+ ++ +Q+QL +
Sbjct: 505 -EKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKE 563
Query: 489 EELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVN 548
+++++ K ++ + + ++T L L+E L + +E + +
Sbjct: 564 KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYK 623
Query: 549 QDRENNIEKRS--QGLKSEKEALLIGI 573
+D ++ EK S QG SEKEA L+ +
Sbjct: 624 KDLKDLKEKVSLLQGDLSEKEASLLDL 650
Score = 40.4 bits (93), Expect = 0.005
Identities = 46/274 (16%), Positives = 107/274 (39%), Gaps = 28/274 (10%)
Query: 294 EVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVF 353
+V R N +++ +R + ++ ++ ++ + + N T + T E +
Sbjct: 539 DVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKE 598
Query: 354 NASTRQKAW-DHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPT 412
R K D + +++ ID ++K ++L+ S L G E+E + D
Sbjct: 599 RTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVS-LLQGDLSEKEASLLD-------- 649
Query: 413 KKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQF 472
+ E A + + LK+++ ++ L+Q+KE+ + E L K +
Sbjct: 650 ----LKEHASSLASSGLKKDSRLKTLEI--------ALEQKKEECLKMESQLKKAHEAAL 697
Query: 473 LQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHS 532
+ M ++ ++ E+ K E +A+ E +LK ++ + + +
Sbjct: 698 EARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQ 757
Query: 533 HEDSNEINVLTVALVNQDRENNIEKRSQGLKSEK 566
+D N+ + N + +EK+ E+
Sbjct: 758 VKDQNK------KVANLKHKEQVEKKKSAQMLEE 785
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 55.1 bits (131), Expect = 2e-07
Identities = 73/304 (24%), Positives = 128/304 (42%), Gaps = 39/304 (12%)
Query: 231 KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
+Q++R RE++ RR+ EE+R H +HE ++LK + + W+
Sbjct: 416 EQQLR-REQQLRREQEEER----------HEQKHEQERREQRLKREQEERR------DWL 458
Query: 291 ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
+R E R + + R E+E E +E + L + EQ
Sbjct: 459 KREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL-----RREQEE 513
Query: 351 AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEE----LRNAQSEQLMGIRREEEMEMSDDE 406
RQ+ + + R + R+ E L+ + ++L RRE+ ++ +E
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE 573
Query: 407 NCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQE---KEQLFRTEEN 463
D K R +E Q +E+ + L +L R EVE L+QE +++L R E
Sbjct: 574 RRDQLLK--REEERR---QQRLKREQEERLEQRLK--REEVERLEQEERREQRLKREEPE 626
Query: 464 LTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTK 523
+ QQL ++ + QQQL Q+E ++ + E EE+ + LK E+ + +
Sbjct: 627 EERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE---EEEERLEQRLKREHEEERREQ 683
Query: 524 ELVE 527
EL E
Sbjct: 684 ELAE 687
Score = 53.5 bits (127), Expect = 6e-07
Identities = 61/298 (20%), Positives = 128/298 (42%), Gaps = 25/298 (8%)
Query: 231 KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEK-LKDDSKFSEAITVLLSW 289
++ R R+E+ R+ EE++L+ + E E+ + D K + LL
Sbjct: 917 EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG- 975
Query: 290 IERGEVNRRSANQF-YSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQ 348
E E RR + Y + +L+ E+ + E ++ K + + EQ
Sbjct: 976 -EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK--DELQQEEEQ 1032
Query: 349 IVAVFNASTR----QKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSD 404
++ R ++ + + Q++ + + E R + E+ R+EEE++ +
Sbjct: 1033 LLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQY--RKEEELQQEE 1090
Query: 405 DENC-DSPTKKMRVDESALAAQAYALKEENDSL---------RWQLDAYRNEVELLKQEK 454
++ + P K+ R + + L++E + L R +L+ E E ++QE+
Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE 1150
Query: 455 EQLFRTEENLTKDQQLQFL---QQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQ 509
EQL R E + Q+L+ ++ +Q ++QLL ++E ++ E + +EE+ Q
Sbjct: 1151 EQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQ 1208
Score = 52.0 bits (123), Expect = 2e-06
Identities = 83/387 (21%), Positives = 151/387 (39%), Gaps = 66/387 (17%)
Query: 213 RLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEK 272
RL Q RD+ W +Q + REER + EE++L+ + + E E
Sbjct: 160 RLEQRDRQRRDEEL-WRQRQEWQEREER---RAEEEQLQSCKGHETEEFPDEEQLRRREL 215
Query: 273 LKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAK 332
L+ K E E+ + R ++ + + R + K + + EE +
Sbjct: 216 LELRRKGRE---------EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266
Query: 333 ENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLM 392
+ + + EQ+ + R++ + + QR + ++LR Q E+
Sbjct: 267 RQRE-----LQEEEEQLRKLERQELRRERQEEEQQQQRL------RREQQLRRKQEEE-- 313
Query: 393 GIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQ 452
RRE++ E + + ++ R E L + +E+ LR + + R E +L ++
Sbjct: 314 --RREQQEERREQQERREQQEERR--EQQLRREQEERREQQ--LRREQEEERREQQLRRE 367
Query: 453 EKEQLFRTEENLTKDQQLQFLQQTMQGMQ----------------------QQLLTIQEE 490
++E+ R E+ L ++QQL+ QQ + Q QQL Q+
Sbjct: 368 QEEE--RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 425
Query: 491 LNNKKSELEQAKEEQSHTQALLKVLQEQLKG-TKELVETNGHSHE---------DSNEIN 540
++ E + K EQ + LK QE+ + K ET H E E
Sbjct: 426 RREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR 485
Query: 541 VLTVALVNQDRENNIEKRSQGLKSEKE 567
+ L ++R E+R Q L+ E+E
Sbjct: 486 ERWLKLEEEERREQQERREQQLRREQE 512
Score = 51.6 bits (122), Expect = 2e-06
Identities = 72/369 (19%), Positives = 140/369 (37%), Gaps = 28/369 (7%)
Query: 207 DKKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEA 266
++++ R + + +++ E + ++ R E+ R+ +E+ R E
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375
Query: 267 ALLAEK-LKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHE 325
L E+ L+ + + + R E R Q Q R E+ HE
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHE 435
Query: 326 Q--EMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL 383
Q E E ++ K ++ ++ + + + W K EE
Sbjct: 436 QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEE 495
Query: 384 RNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDE--SALAAQAYALKEENDSLRWQLD 441
R Q E RRE+++ +E + K+ +E L+ E + R QL
Sbjct: 496 RREQQE-----RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550
Query: 442 AYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNN---KKSEL 498
E L ++ +EQ + E+ +DQ L++ + QQ+L QEE K+ E+
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQ---LLKREEERRQQRLKREQEERLEQRLKREEV 607
Query: 499 EQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKR 558
E+ ++E+ Q L + E+ + ++L+++ ++ R E+R
Sbjct: 608 ERLEQEERREQRLKREEPEE-ERRQQLLKSEEQEERRQQQL-----------RREQQERR 655
Query: 559 SQGLKSEKE 567
Q LK E+E
Sbjct: 656 EQRLKREEE 664
Score = 51.6 bits (122), Expect = 2e-06
Identities = 71/382 (18%), Positives = 152/382 (39%), Gaps = 36/382 (9%)
Query: 208 KKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAA 267
K++ R + +++ E K+ R E+ R+ E RL+ P E
Sbjct: 580 KREEERRQQRLKREQEERLEQRLKREEVERLEQEERR--EQRLKREEPE-----EERRQQ 632
Query: 268 LLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQE 327
LL + +++ + + + ER E + + + Q E+ E+E
Sbjct: 633 LLKSEEQEERRQQQ---LRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEE 689
Query: 328 MEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ 387
E+A+E K+ + Q E + + + +R+ + R+ E Q
Sbjct: 690 QEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ 749
Query: 388 SEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEV 447
E+ +++EE + D +K L+A+ ++ LR + + + E
Sbjct: 750 EEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE-ERQQREQ 808
Query: 448 ELLKQEKEQLFRTEENLTKDQQLQFLQ--------QTMQGMQQQLLTIQEELNNKKS--- 496
L +E+E+ R + ++++LQFL+ + Q +Q++ +QE+ ++S
Sbjct: 809 RFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQ 868
Query: 497 --------ELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVN 548
+LE+ ++ + HT LQEQL+ ++L++ E+ E+
Sbjct: 869 RRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ------EEEEELQREEREKRR 922
Query: 549 QDRENNIEKRSQGLKSEKEALL 570
+ + + + L+ E+E LL
Sbjct: 923 RQEQERQYREEEQLQQEEEQLL 944
Score = 47.0 bits (110), Expect = 5e-05
Identities = 69/325 (21%), Positives = 131/325 (40%), Gaps = 34/325 (10%)
Query: 220 QARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKF 279
Q RD + E +Q ++ REE+ + E DR P + E E L ++ D KF
Sbjct: 1615 QERDRKFR-EDEQLLQEREEQQLHRQERDRKFLEEEPQLRR-QEREQQLRHDR---DRKF 1669
Query: 280 SEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNAL 339
E +L + GE + + + +RR E+ ++E + ++ +
Sbjct: 1670 REEEQLL----QEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKF 1725
Query: 340 TG---ILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRR 396
+ + EQ R+ + + +R+ + R+ + + + EQL R
Sbjct: 1726 REEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQL-RRQERDRKFREEEQLRQERE 1784
Query: 397 EEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQ 456
E+++ + + +++R + Q ++ + RW+ E +L +E+EQ
Sbjct: 1785 EQQLRSQESDRKFREEEQLRQEREE---QQLRPQQRDGKYRWE------EEQLQLEEQEQ 1835
Query: 457 LFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELE----------QAKEEQS 506
R E + + QF Q ++Q L QEE ++ E E Q KEEQ
Sbjct: 1836 RLRQERDRQYRAEEQFATQEKSRREEQELW-QEEEQKRRQERERKLREEHIRRQQKEEQR 1894
Query: 507 HTQALLKVLQEQLKGTKELVETNGH 531
H Q + ++ ++ KG L+E H
Sbjct: 1895 HRQ-VGEIKSQEGKGHGRLLEPGTH 1918
Score = 46.2 bits (108), Expect = 9e-05
Identities = 85/376 (22%), Positives = 149/376 (39%), Gaps = 69/376 (18%)
Query: 220 QARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKD-DSK 278
Q RD ++W+ +++ ER R++L RPP + E L AE+ + + +
Sbjct: 763 QRRDFTWQWQAEEK----SERGRQRLSA---RPPLR------EQRERQLRAEERQQREQR 809
Query: 279 FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNA 338
F L E E RR + +Q + E+A QE E+
Sbjct: 810 F-------LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDG------- 855
Query: 339 LTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL---MGIR 395
Q +Q R + W + +RK R+H+ + A EQL +
Sbjct: 856 -----LQEDQERRRSQEQRRDQKWRWQLEEERKR----RRHTLYAKPALQEQLRKEQQLL 906
Query: 396 REEEMEMSDDEN----CDSPTKKMRVDESALAAQAYALKEENDSLRWQLDA--YRNEVEL 449
+EEE E+ +E ++ R +E + L+EE + R Q YR + +L
Sbjct: 907 QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL 966
Query: 450 L---------------KQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNK 494
+QE+E+ +R EE L ++++ Q L++ + ++Q E K
Sbjct: 967 QQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE-QLLREEREKRRRQEW---ERQYRK 1022
Query: 495 KSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENN 554
K EL+Q +E+ + + LQE+ + +E E E+ + Q+ E
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEEL---QQEEEQLLGEERETRRRQELERQ 1079
Query: 555 IEKRSQGLKSEKEALL 570
K + L+ E+E LL
Sbjct: 1080 YRKEEE-LQQEEEQLL 1094
Score = 45.1 bits (105), Expect = 2e-04
Identities = 71/367 (19%), Positives = 147/367 (40%), Gaps = 40/367 (10%)
Query: 220 QARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKD---- 275
Q++ D +Q+ R RE+ RR + DR H+ E E L E+ K+
Sbjct: 1262 QSQQDLQHLLGEQQERDREQERRRWQQRDR----------HFPEEEQ-LEREEQKEAKRR 1310
Query: 276 DSKFSEAITVLLSWIE----RGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEA 331
D K E +L E R E +R+ + + + +RR ++ E+E+
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370
Query: 332 KENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL 391
++ K + ++ F +Q + R++ D RK EE + ++
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD--RKFREEEQQLSRQER 1428
Query: 392 MGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYR------- 444
REEE ++ E +K +E L + + E + L + + +
Sbjct: 1429 DRKFREEEQQVRRQER----ERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERD 1484
Query: 445 -----NEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELE 499
E +L +QE+++ FR +E +++ + +FL++ Q +QQ Q + ++ +L
Sbjct: 1485 RKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQR---QRKFLQEEQQLR 1541
Query: 500 QAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRS 559
+ + Q Q + +E+ + +E E E + + + Q++E +
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE 1601
Query: 560 QGLKSEK 566
Q L+ ++
Sbjct: 1602 QQLRRQE 1608
Score = 44.7 bits (104), Expect = 3e-04
Identities = 71/373 (19%), Positives = 147/373 (39%), Gaps = 60/373 (16%)
Query: 227 EWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVL 286
E + ++ REER +R+L+E + + E E E+L + + + L
Sbjct: 1025 ELQQEEEQLLREEREKRRLQERERQ--------YREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 287 LSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENF------KNALT 340
+ E ++ Q + + R+ + E+E+++ +E K
Sbjct: 1077 ERQYRKEEELQQEEEQL--LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQ 1134
Query: 341 GILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGI-----R 395
+ Q+ + V Q + K +R+ ++ + EEL+ + EQL+ R
Sbjct: 1135 ELERQYREEEEV-QQEEEQLLREEPEKRRRQELERQYREEEELQQ-EEEQLLREEQEKRR 1192
Query: 396 REEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYR------NEVEL 449
+E E + ++E +K R Y +++ L+WQ + + N+V
Sbjct: 1193 QERERQYREEEELQRQKRKQR----------YRDEDQRSDLKWQWEPEKENAVRDNKVYC 1242
Query: 450 LKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQ-------------EELNNKKS 496
+E EQ + E++ +D+Q Q Q + G QQ+ Q EE ++
Sbjct: 1243 KGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLERE 1302
Query: 497 ELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIE 556
E ++AK +Q ++L+E+ + + ET+ E+ L+ + E +
Sbjct: 1303 EQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQ--------LLQEREEQPLR 1354
Query: 557 KRSQGLKSEKEAL 569
++ + K +E L
Sbjct: 1355 RQERDRKFREEEL 1367
Score = 42.0 bits (97), Expect = 0.002
Identities = 68/366 (18%), Positives = 141/366 (38%), Gaps = 53/366 (14%)
Query: 208 KKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAA 267
+K+ +L + Q + + E E + R R+E R + EE++
Sbjct: 254 RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQ---------QQQRLRREQ 304
Query: 268 LLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQE 327
L K +++ + E+ E R + + +RR E+ +
Sbjct: 305 QLRRKQEEERR------------EQQEERREQQERREQQEERREQQLRREQEERREQQLR 352
Query: 328 MEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ 387
E+ +E + L + + + ++ + Q + R+ + R Q
Sbjct: 353 REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 412
Query: 388 SEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEV 447
+ +RRE+++ +E + E L + +E D L+ + + R+E
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ---EERRDWLKREEETERHEQ 469
Query: 448 ELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQ----QQLLTIQEELNNKKSELEQAKE 503
E + K+QL R +E +++ L+ ++ + Q QQL QEE ++ L++ +E
Sbjct: 470 E---RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE--RREQRLKRQEE 524
Query: 504 EQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNI--EKRSQG 561
E+ LQ++L+ ++L E L+ ++ E + E+R Q
Sbjct: 525 EER--------LQQRLRSEQQLRREQEERREQ----------LLKREEEKRLEQERREQR 566
Query: 562 LKSEKE 567
LK E+E
Sbjct: 567 LKREQE 572
Score = 40.8 bits (94), Expect = 0.004
Identities = 79/355 (22%), Positives = 145/355 (40%), Gaps = 69/355 (19%)
Query: 229 ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
E +QR+R R+ER R+ L+E++ + E E L ++ D KF E
Sbjct: 1378 EEEQRLR-RQERERKFLKEEQQ--------LRCQEREQQLRQDR---DRKFRE------- 1418
Query: 289 WIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQ 348
E +++R+ ++ + + VRR E+ E+E + +E + + EQ
Sbjct: 1419 --EEQQLSRQERDRKF---REEEQQVRRQERERKFLEEEQQLRQERHRK-----FREEEQ 1468
Query: 349 IVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENC 408
++ R++ H + RK ++ ++LR + + R+ E E+ E
Sbjct: 1469 LL-----QEREEQQLHRQERDRKFLE----EEQQLRRQERD-----RKFREQELRSQE-- 1512
Query: 409 DSPTKKMRVDESALAAQAYALK--EENDSLRWQ---------LDAYRNEVELLKQEKE-- 455
P +K +E L Q K +E LR Q D E E L+QE+E
Sbjct: 1513 --PERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQ 1570
Query: 456 QLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVL 515
QL R E +D++ + +Q ++ +Q+ +++E +L + + +Q Q +
Sbjct: 1571 QLSRQE----RDRKFRLEEQKVRRQEQERKFMEDE-----QQLRRQEGQQQLRQERDRKF 1621
Query: 516 QEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEALL 570
+E + +E E H E + L Q+RE + E+E LL
Sbjct: 1622 REDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLL 1676
Score = 38.1 bits (87), Expect = 0.025
Identities = 49/244 (20%), Positives = 99/244 (40%), Gaps = 19/244 (7%)
Query: 235 RAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKL--KDDSKFSEAITVLLSWIER 292
R R+ER ++ EE+ L+ + E E+ K D E +L E+
Sbjct: 981 RRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK 1040
Query: 293 GEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAV 352
+ R Y + +L+ E+ + E ++ K + + EQ++
Sbjct: 1041 RRLQERERQ--YREEEELQQEEEQLLGEERETRRRQELERQYRKEE--ELQQEEEQLLRE 1096
Query: 353 F----NASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENC 408
R++ + Q++ + R+ E+ R + E+ R EEE++ +++
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQY--REEEEVQQEEEQLL 1154
Query: 409 -DSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKD 467
+ P K+ R + + L++E + L R E E +QE+E+ +R EE L +
Sbjct: 1155 REEPEKRRRQELERQYREEEELQQEEEQL------LREEQEKRRQERERQYREEEELQRQ 1208
Query: 468 QQLQ 471
++ Q
Sbjct: 1209 KRKQ 1212
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 55.1 bits (131), Expect = 2e-07
Identities = 63/301 (20%), Positives = 127/301 (42%), Gaps = 27/301 (8%)
Query: 242 RRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSAN 301
R KL E +L ++ E + A L +L++ + +++ + L +++ +
Sbjct: 953 RYKLLESKLESTLKKSL-EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1011
Query: 302 QFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKA 361
MVQS+ + E E+E +E +L ++++ V + +A
Sbjct: 1012 DEERMVQSSPP----ISGEDNKWERESQETTRE-------LLKVKDRLIEVERNNATLQA 1060
Query: 362 WDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESA 421
K Q K + E N Q++ ++R+ + + K++V+ S
Sbjct: 1061 EKQALKTQLKQL-------ETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENST 1113
Query: 422 LAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKD-QQLQFLQQTMQGM 480
L +Q+ +L +N L Q + NE E + +E+E L ++L KD ++L+ L +
Sbjct: 1114 LNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASE 1173
Query: 481 QQQLLTIQEELN--NKKSELEQAKEEQSHTQAL-----LKVLQEQLKGTKELVETNGHSH 533
+ L++ L +K E+E E + Q L L+ L++ LK +E + +H
Sbjct: 1174 YESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNH 1233
Query: 534 E 534
E
Sbjct: 1234 E 1234
Score = 44.3 bits (103), Expect = 4e-04
Identities = 68/354 (19%), Positives = 148/354 (41%), Gaps = 44/354 (12%)
Query: 232 QRMRAREERHRRKLEEDRLR-PPSPPAIMHYSEHEAALLAEKLKDDSKF-SEAITVLLSW 289
+ +R ER + LE++ + ++ S+ A + ++ ++K E+I S
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602
Query: 290 IERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQI 349
+ + E +R + + L NE +E+ E + +T + E+I
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENEL----HHLEKENELLQKKITNLKITCEKI 658
Query: 350 VAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCD 409
A+ ++ + ++ +K +D ++ + +L + E+E D+EN +
Sbjct: 659 EALEQENSEL---ERENRKLKKTLDSFKNLTFQLESL----------EKENSQLDEENLE 705
Query: 410 SPTKKMRVDESALAAQAYA-LKEENDSLRWQLDAYRNEVELLKQ---------------- 452
+ V+ A+ A L+ EN L + + + +ELLK
Sbjct: 706 L---RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLD 762
Query: 453 -EKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQAL 511
E ++L +T EN K ++Q L+ +Q ++ + T+Q+ L K ++ ++ + ++L
Sbjct: 763 IENQRLQKTLENSNK--KIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSL 820
Query: 512 LKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSE 565
+ + K K+L + N + + EI T+ N + N+EK ++ L E
Sbjct: 821 EQETSQLEKDKKQLEKENKRLRQQA-EIKDTTLE-ENNVKIGNLEKENKTLSKE 872
Score = 42.7 bits (99), Expect = 0.001
Identities = 60/285 (21%), Positives = 124/285 (43%), Gaps = 13/285 (4%)
Query: 295 VNRRSANQFYSM-VQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILT-QFEQIVAV 352
+ R + Q S+ + A + +RRL E +++ + K+ + + Q E + +
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 353 FNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPT 412
+A + + D + K + + + SE R + + + E+ +D T
Sbjct: 300 SDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET 359
Query: 413 KKMRVDE----SALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQ 468
K M D+ A + + + L++EN L+ +L E ++ +++ E+L EEN+T +
Sbjct: 360 KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM--EENMTLEM 417
Query: 469 -QLQFLQQTMQ-GMQQQLLTIQEELNN--KKSELEQAKEEQSHTQALLKVLQEQLKGTKE 524
Q Q + +++ G + + ++ EL+ +KS + E S L++ + L T E
Sbjct: 418 AQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVE 477
Query: 525 LVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEAL 569
+ T S E N +L + NQ +E + EK++L
Sbjct: 478 ELRTTVDSVE-GNASKILKMEKENQRLSKKVEILENEIVQEKQSL 521
Score = 40.0 bits (92), Expect = 0.007
Identities = 73/360 (20%), Positives = 153/360 (42%), Gaps = 58/360 (16%)
Query: 229 ECKQRMRARE-ERHRRKLEEDRLRPPSPPAIMHYSE----HEAALLAEKLKDD-SKFSEA 282
+CKQ + E E R + E L + A M+ E E A+ +KL+ + S++ E
Sbjct: 276 DCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKER 335
Query: 283 ITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGI 342
+ + +FY + + E Q + E K ++ L G
Sbjct: 336 LHDI---------------EFY----------KARVEELKEDNQVLLETKTMLEDQLEGT 370
Query: 343 LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRN-------AQSEQL---M 392
+ +++ + + + KA H + +R D+ RK EEL AQ + + +
Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMER---DMDRKKIEELMEENMTLEMAQKQSMDESL 427
Query: 393 GIRREEEMEMSDDENCDSPTKKMRVDESAL-AAQAYALKEENDSLRWQLDAYRNEVE--- 448
+ E E E ++P K + + + L +++ L+ EN SL ++ R V+
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVE 487
Query: 449 -----LLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKE 503
+LK EKE +++ + ++ +Q++Q Q + ++L +K++LE+ E
Sbjct: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ----NLSKDLMKEKAQLEKTIE 543
Query: 504 E-QSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGL 562
+ +++ +K+L+++ + + V + + S E V + N+ +I++ S L
Sbjct: 544 TLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL 603
Score = 38.5 bits (88), Expect = 0.019
Identities = 83/494 (16%), Positives = 202/494 (40%), Gaps = 47/494 (9%)
Query: 151 ENATEEIIQEVFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTDKKD 210
+N ++++++E + I +R++ + I E +++ + R ++ + KD
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD 584
Query: 211 SGR----LHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEA 266
+ LH + + E ++R +E H ++ E R +H+ E E
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE---RAEELENELHHLEKEN 641
Query: 267 ALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQ 326
LL +K+ + E I L E R + ++ + L E + ++
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701
Query: 327 EMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNA 386
E E + N ++ + + K + + +K +++ + ++
Sbjct: 702 ENLELRRNVESLKCASMKMAQ-------LQLENKELESEKEQLKKGLELLKASFKKTERL 754
Query: 387 Q-SEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRN 445
+ S Q + I + + ++ N KK++ ES L L+ EN +L+ L+
Sbjct: 755 EVSYQGLDIENQRLQKTLENSN-----KKIQQLESELQD----LEMENQTLQKNLE---- 801
Query: 446 EVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQ 505
E+++ + EQL +EN + +Q+ L++ + ++++ ++++ K + LE+ +
Sbjct: 802 ELKISSKRLEQL--EKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI 859
Query: 506 SHTQALLKVLQEQLKGTKELVETNGHSHEDSNE------INVLTVALVNQDRENNIEKRS 559
+ + K L +++ KE +++ E I++ T+ + +D + + ++
Sbjct: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE-KLKT 918
Query: 560 QGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDS---KISANEIEMLLMRLPRM 616
Q + ++ E L + G N E L Q D K+ +++E L + +
Sbjct: 919 QQMNNDLEKLT-------HELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEI 971
Query: 617 FKQEFTGVGATLEK 630
+++ + A LE+
Sbjct: 972 KEEKIAALEARLEE 985
Score = 38.5 bits (88), Expect = 0.019
Identities = 50/219 (22%), Positives = 93/219 (42%), Gaps = 33/219 (15%)
Query: 317 LMNEKATHEQEMEEAKEN-FKNALTGILTQFEQIVAVFNASTRQKAW----DHFSKAQRK 371
L++E+ E E +K K+A + + + +N +QK + K +++
Sbjct: 1165 LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQE 1224
Query: 372 NIDIWRKHSEELRNAQSEQLMG-----------IRREEEMEMSDDENCDSPTKKMRVDES 420
+ + K+ E + A+ ++L G + +E E+ +D +N S +++++
Sbjct: 1225 KMLLENKNHETVA-AEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT 1283
Query: 421 ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQ--------F 472
L A+ LKE+ L N+ ELL Q K L EEN Q+Q
Sbjct: 1284 RLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL--EEENRHLLDQIQTLMLQNRTL 1341
Query: 473 LQQTMQGM------QQQLLTIQEELNNKKSELEQAKEEQ 505
L+Q M+ Q+Q + EL +K +LE+ +Q
Sbjct: 1342 LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1380
Score = 35.0 bits (79), Expect = 0.21
Identities = 45/210 (21%), Positives = 93/210 (44%), Gaps = 25/210 (11%)
Query: 370 RKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKK-------MRVDESAL 422
++ ID +HSE + SE+ G+ S C SP K + V+ +
Sbjct: 198 KRLIDERDEHSETIIEL-SEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADA 256
Query: 423 AAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKD--------QQLQFLQ 474
A+ L++E + QL + E+E ++ E ++L + NL D +L L+
Sbjct: 257 KAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALR 316
Query: 475 Q---TMQGMQQQLLTIQEELNN---KKSELEQAKEEQSHTQALLKVLQEQLKGTKELVET 528
+ + ++ ++ +E L++ K+ +E+ KE+ +L++QL+GT+
Sbjct: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTR---AR 373
Query: 529 NGHSHEDSNEINVLTVALVNQDRENNIEKR 558
+ HE E L L + + E +++++
Sbjct: 374 SDKLHELEKENLQLKAKLHDMEMERDMDRK 403
Score = 29.6 bits (65), Expect = 9.0
Identities = 63/300 (21%), Positives = 120/300 (40%), Gaps = 46/300 (15%)
Query: 281 EAITVLLSWIERGEVNRRSANQFYSMVQSANSHV----RRLMNEKATHEQEMEEAKENFK 336
E + + +E+ E +S Q S ++ + +RL + + +EE
Sbjct: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860
Query: 337 NALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRR 396
N T ++I + R K + +K K I K LR E L+ +
Sbjct: 861 NLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLR----EDLVSEKL 916
Query: 397 EEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVEL-----LK 451
+ + +D E +K+ +++ L ++ D R++L + E L +K
Sbjct: 917 KTQQMNNDLEKLTHELEKIGLNKERLLHD----EQSTDDSRYKLLESKLESTLKKSLEIK 972
Query: 452 QEKEQLF--RTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQ 509
+EK R EE+ +QQL +Q+L T+++ L+Q ++E+ Q
Sbjct: 973 EEKIAALEARLEESTNYNQQL----------RQELKTVKKNY----EALKQRQDEERMVQ 1018
Query: 510 ALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEAL 569
+ + E K +E S E + E+ L +DR +E+ + L++EK+AL
Sbjct: 1019 SSPPISGEDNKWERE-------SQETTREL------LKVKDRLIEVERNNATLQAEKQAL 1065
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 55.1 bits (131), Expect = 2e-07
Identities = 63/301 (20%), Positives = 127/301 (42%), Gaps = 27/301 (8%)
Query: 242 RRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSAN 301
R KL E +L ++ E + A L +L++ + +++ + L +++ +
Sbjct: 952 RYKLLESKLESTLKKSL-EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1010
Query: 302 QFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKA 361
MVQS+ + E E+E +E +L ++++ V + +A
Sbjct: 1011 DEERMVQSSPP----ISGEDNKWERESQETTRE-------LLKVKDRLIEVERNNATLQA 1059
Query: 362 WDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESA 421
K Q K + E N Q++ ++R+ + + K++V+ S
Sbjct: 1060 EKQALKTQLKQL-------ETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENST 1112
Query: 422 LAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKD-QQLQFLQQTMQGM 480
L +Q+ +L +N L Q + NE E + +E+E L ++L KD ++L+ L +
Sbjct: 1113 LNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASE 1172
Query: 481 QQQLLTIQEELN--NKKSELEQAKEEQSHTQAL-----LKVLQEQLKGTKELVETNGHSH 533
+ L++ L +K E+E E + Q L L+ L++ LK +E + +H
Sbjct: 1173 YESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNH 1232
Query: 534 E 534
E
Sbjct: 1233 E 1233
Score = 44.3 bits (103), Expect = 4e-04
Identities = 68/354 (19%), Positives = 148/354 (41%), Gaps = 44/354 (12%)
Query: 232 QRMRAREERHRRKLEEDRLR-PPSPPAIMHYSEHEAALLAEKLKDDSKF-SEAITVLLSW 289
+ +R ER + LE++ + ++ S+ A + ++ ++K E+I S
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602
Query: 290 IERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQI 349
+ + E +R + + L NE +E+ E + +T + E+I
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENEL----HHLEKENELLQKKITNLKITCEKI 658
Query: 350 VAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCD 409
A+ ++ + ++ +K +D ++ + +L + E+E D+EN +
Sbjct: 659 EALEQENSEL---ERENRKLKKTLDSFKNLTFQLESL----------EKENSQLDEENLE 705
Query: 410 SPTKKMRVDESALAAQAYA-LKEENDSLRWQLDAYRNEVELLKQ---------------- 452
+ V+ A+ A L+ EN L + + + +ELLK
Sbjct: 706 L---RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLD 762
Query: 453 -EKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQAL 511
E ++L +T EN K ++Q L+ +Q ++ + T+Q+ L K ++ ++ + ++L
Sbjct: 763 IENQRLQKTLENSNK--KIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSL 820
Query: 512 LKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSE 565
+ + K K+L + N + + EI T+ N + N+EK ++ L E
Sbjct: 821 EQETSQLEKDKKQLEKENKRLRQQA-EIKDTTLE-ENNVKIGNLEKENKTLSKE 872
Score = 42.7 bits (99), Expect = 0.001
Identities = 60/285 (21%), Positives = 124/285 (43%), Gaps = 13/285 (4%)
Query: 295 VNRRSANQFYSM-VQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILT-QFEQIVAV 352
+ R + Q S+ + A + +RRL E +++ + K+ + + Q E + +
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 353 FNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPT 412
+A + + D + K + + + SE R + + + E+ +D T
Sbjct: 300 SDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET 359
Query: 413 KKMRVDE----SALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQ 468
K M D+ A + + + L++EN L+ +L E ++ +++ E+L EEN+T +
Sbjct: 360 KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM--EENMTLEM 417
Query: 469 -QLQFLQQTMQ-GMQQQLLTIQEELNN--KKSELEQAKEEQSHTQALLKVLQEQLKGTKE 524
Q Q + +++ G + + ++ EL+ +KS + E S L++ + L T E
Sbjct: 418 AQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVE 477
Query: 525 LVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEAL 569
+ T S E N +L + NQ +E + EK++L
Sbjct: 478 ELRTTVDSVE-GNASKILKMEKENQRLSKKVEILENEIVQEKQSL 521
Score = 40.0 bits (92), Expect = 0.007
Identities = 73/360 (20%), Positives = 153/360 (42%), Gaps = 58/360 (16%)
Query: 229 ECKQRMRARE-ERHRRKLEEDRLRPPSPPAIMHYSE----HEAALLAEKLKDD-SKFSEA 282
+CKQ + E E R + E L + A M+ E E A+ +KL+ + S++ E
Sbjct: 276 DCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKER 335
Query: 283 ITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGI 342
+ + +FY + + E Q + E K ++ L G
Sbjct: 336 LHDI---------------EFY----------KARVEELKEDNQVLLETKTMLEDQLEGT 370
Query: 343 LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRN-------AQSEQL---M 392
+ +++ + + + KA H + +R D+ RK EEL AQ + + +
Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMER---DMDRKKIEELMEENMTLEMAQKQSMDESL 427
Query: 393 GIRREEEMEMSDDENCDSPTKKMRVDESAL-AAQAYALKEENDSLRWQLDAYRNEVE--- 448
+ E E E ++P K + + + L +++ L+ EN SL ++ R V+
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVE 487
Query: 449 -----LLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKE 503
+LK EKE +++ + ++ +Q++Q Q + ++L +K++LE+ E
Sbjct: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ----NLSKDLMKEKAQLEKTIE 543
Query: 504 E-QSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGL 562
+ +++ +K+L+++ + + V + + S E V + N+ +I++ S L
Sbjct: 544 TLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL 603
Score = 38.9 bits (89), Expect = 0.015
Identities = 83/493 (16%), Positives = 202/493 (40%), Gaps = 46/493 (9%)
Query: 151 ENATEEIIQEVFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTDKKD 210
+N ++++++E + I +R++ + I E +++ + R ++ + KD
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD 584
Query: 211 SGR----LHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEA 266
+ LH + + E ++R +E H ++ E R +H+ E E
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE---RAEELENELHHLEKEN 641
Query: 267 ALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQ 326
LL +K+ + E I L E R + ++ + L E + ++
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701
Query: 327 EMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNA 386
E E + N ++ + + K + + +K +++ + ++
Sbjct: 702 ENLELRRNVESLKCASMKMAQ-------LQLENKELESEKEQLKKGLELLKASFKKTERL 754
Query: 387 Q-SEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRN 445
+ S Q + I + + ++ N KK++ ES L L+ EN +L+ L+
Sbjct: 755 EVSYQGLDIENQRLQKTLENSN-----KKIQQLESELQD----LEMENQTLQKNLE---- 801
Query: 446 EVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQ 505
E+++ + EQL +EN + +Q+ L++ + ++++ ++++ K + LE+ +
Sbjct: 802 ELKISSKRLEQL--EKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI 859
Query: 506 SHTQALLKVLQEQLKGTKELVETNGHSHEDSNE------INVLTVALVNQDRENNIEKRS 559
+ + K L +++ KE +++ E I++ T+ + +D + + ++
Sbjct: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE-KLKT 918
Query: 560 QGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDS--KISANEIEMLLMRLPRMF 617
Q + ++ E L + G N E L Q D K+ +++E L + +
Sbjct: 919 QQMNNDLEKLT-------HELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIK 971
Query: 618 KQEFTGVGATLEK 630
+++ + A LE+
Sbjct: 972 EEKIAALEARLEE 984
Score = 38.5 bits (88), Expect = 0.019
Identities = 50/219 (22%), Positives = 93/219 (42%), Gaps = 33/219 (15%)
Query: 317 LMNEKATHEQEMEEAKEN-FKNALTGILTQFEQIVAVFNASTRQKAW----DHFSKAQRK 371
L++E+ E E +K K+A + + + +N +QK + K +++
Sbjct: 1164 LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQE 1223
Query: 372 NIDIWRKHSEELRNAQSEQLMG-----------IRREEEMEMSDDENCDSPTKKMRVDES 420
+ + K+ E + A+ ++L G + +E E+ +D +N S +++++
Sbjct: 1224 KMLLENKNHETVA-AEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT 1282
Query: 421 ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQ--------F 472
L A+ LKE+ L N+ ELL Q K L EEN Q+Q
Sbjct: 1283 RLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL--EEENRHLLDQIQTLMLQNRTL 1340
Query: 473 LQQTMQGM------QQQLLTIQEELNNKKSELEQAKEEQ 505
L+Q M+ Q+Q + EL +K +LE+ +Q
Sbjct: 1341 LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1379
Score = 35.0 bits (79), Expect = 0.21
Identities = 45/210 (21%), Positives = 93/210 (44%), Gaps = 25/210 (11%)
Query: 370 RKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKK-------MRVDESAL 422
++ ID +HSE + SE+ G+ S C SP K + V+ +
Sbjct: 198 KRLIDERDEHSETIIEL-SEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADA 256
Query: 423 AAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKD--------QQLQFLQ 474
A+ L++E + QL + E+E ++ E ++L + NL D +L L+
Sbjct: 257 KAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALR 316
Query: 475 Q---TMQGMQQQLLTIQEELNN---KKSELEQAKEEQSHTQALLKVLQEQLKGTKELVET 528
+ + ++ ++ +E L++ K+ +E+ KE+ +L++QL+GT+
Sbjct: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTR---AR 373
Query: 529 NGHSHEDSNEINVLTVALVNQDRENNIEKR 558
+ HE E L L + + E +++++
Sbjct: 374 SDKLHELEKENLQLKAKLHDMEMERDMDRK 403
Score = 32.0 bits (71), Expect = 1.8
Identities = 60/295 (20%), Positives = 118/295 (40%), Gaps = 37/295 (12%)
Query: 281 EAITVLLSWIERGEVNRRSANQFYSMVQSANSHV----RRLMNEKATHEQEMEEAKENFK 336
E + + +E+ E +S Q S ++ + +RL + + +EE
Sbjct: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860
Query: 337 NALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRR 396
N T ++I + R K + +K K I K LR E L+ +
Sbjct: 861 NLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLR----EDLVSEKL 916
Query: 397 EEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQ 456
+ + +D E +K+ +++ L + + L +L++ + +K+EK
Sbjct: 917 KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIA 976
Query: 457 LF--RTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKV 514
R EE+ +QQL +Q+L T+++ L+Q ++E+ Q+ +
Sbjct: 977 ALEARLEESTNYNQQL----------RQELKTVKKNY----EALKQRQDEERMVQSSPPI 1022
Query: 515 LQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEAL 569
E K +E S E + E+ L +DR +E+ + L++EK+AL
Sbjct: 1023 SGEDNKWERE-------SQETTREL------LKVKDRLIEVERNNATLQAEKQAL 1064
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 54.7 bits (130), Expect = 3e-07
Identities = 57/225 (25%), Positives = 101/225 (44%), Gaps = 26/225 (11%)
Query: 370 RKNIDIWRKHSEELRNAQSEQLMGIRREEEM--EMSDDENC---------------DSPT 412
R+ ++ E LR Q+E + R E+ E+S EN +
Sbjct: 546 REALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALN 605
Query: 413 KKMRVDESALAAQAYALKEENDSLRWQLDAYRN-----EVELLKQEKEQLFRTEENLTKD 467
+ + +D+ L Q L+EEN S+ +++A +V+L + EK + E+N +
Sbjct: 606 EALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLE 665
Query: 468 QQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVE 527
QLQ ++ +Q L IQEE + +L +++ +Q L+ L ++ K +E++
Sbjct: 666 AQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLA 725
Query: 528 TNGHSHED-SNEINVLTVAL--VNQDRENNIEKRSQGLKSEKEAL 569
E E L V L V +DR+ ++ ++ QGL S KE L
Sbjct: 726 RAVQEKEALVREKAALEVRLQAVERDRQ-DLAEQLQGLSSAKELL 769
Score = 47.0 bits (110), Expect = 5e-05
Identities = 88/420 (20%), Positives = 172/420 (40%), Gaps = 62/420 (14%)
Query: 208 KKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAI---MHYSEH 264
++D +L VD+++ARD+ E + +M + K E RL + H+ E
Sbjct: 135 REDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEM 194
Query: 265 EAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLM------ 318
++A + ++ ++ LL+ R V +S S + L+
Sbjct: 195 KSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQ 254
Query: 319 -NEKATHE--QEMEEAKENFKNALTGILTQFEQIVAVFNASTRQ-KAWDHFSKAQRKNID 374
EK HE QE+ + K + + ++ A+ S +Q + ++ KA R+ ++
Sbjct: 255 ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVE 314
Query: 375 IWRKHSEEL--------RNAQSEQL---------------------MGIRREEEMEMS-- 403
I + EL RNAQ E+L G E +E+
Sbjct: 315 ILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSS 374
Query: 404 -----DDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLF 458
D ++ D K + + S L + A+++ LR QL + V LL+Q+ +Q
Sbjct: 375 IFSQFDYQDAD---KALTLVRSVLTRRRQAVQD----LRQQLAGCQEAVNLLQQQHDQW- 426
Query: 459 RTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQ 518
EE Q+LQ L + Q + +Q E+++ E E ++ + + L+VL+++
Sbjct: 427 -EEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQE 485
Query: 519 ---LKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEALLIGIIS 575
L+ ++ G S + E + L ++RE +++ GL++++ L +I+
Sbjct: 486 AWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERE-RLQEMLMGLEAKQSESLSELIT 544
Score = 44.3 bits (103), Expect = 4e-04
Identities = 62/297 (20%), Positives = 123/297 (41%), Gaps = 24/297 (8%)
Query: 266 AALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHE 325
+ALL + K + + + I L +E E N + + + S N+ +L ++ +
Sbjct: 289 SALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASL-SRNAQEEKLSLQQVIKD 347
Query: 326 --QEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL 383
Q M E +N +G E ++F+ Q A D R + R+ ++L
Sbjct: 348 ITQVMVEEGDNIAQG-SGHENSLELDSSIFSQFDYQDA-DKALTLVRSVLTRRRQAVQDL 405
Query: 384 RNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAY 443
R +QL G + + + + K +R L + L + L+ ++D+
Sbjct: 406 R----QQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSL 461
Query: 444 RNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKE 503
E ELL++ +E+L QQL+ L+Q +++ + +Q + ++ + + E+ +E
Sbjct: 462 SKERELLQKAREEL---------RQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQE 512
Query: 504 EQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQ 560
E + LQE L G + E +E+ L AL + E + ++ Q
Sbjct: 513 ELHLAVRERERLQEMLMGLE------AKQSESLSELITLREALESSHLEGELLRQEQ 563
Score = 41.6 bits (96), Expect = 0.002
Identities = 62/315 (19%), Positives = 133/315 (42%), Gaps = 37/315 (11%)
Query: 263 EHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKA 322
E E L +LK+ EAI +R E ++ + M L+
Sbjct: 881 EREKMELEMRLKEQQTEMEAIQA-----QREEERTQAESALCQMQLETEKERVSLLETLL 935
Query: 323 THEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEE 382
++E+ +A + + L Q ++ + T +AQR+ + R+H ++
Sbjct: 936 QTQKELADASQQLER-----LRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDD 990
Query: 383 LRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDA 442
L Q E ++ + +++ + D ++ + D+S Q +E + LR +
Sbjct: 991 LAALQEESSSLLQDKMDLQKQVE---DLKSQLVAQDDS----QRLVEQEVQEKLRETQEY 1043
Query: 443 YRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAK 502
R + EL E+E+ T + K+Q+L LQ+ QQ+L +++ ++++A+
Sbjct: 1044 NRIQKEL---EREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQ-------DMQEAQ 1093
Query: 503 EEQSHTQALLKVLQEQLKGTK--------ELVETNGHSHEDSNEINVLTVALVNQDRENN 554
EQ A +++L++++K + +L+E SH ++ A + +
Sbjct: 1094 GEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWA--QEAKAAQ 1151
Query: 555 IEKRSQGLKSEKEAL 569
++ R + +S+ EAL
Sbjct: 1152 LQLRLRSTESQLEAL 1166
Score = 41.6 bits (96), Expect = 0.002
Identities = 88/437 (20%), Positives = 173/437 (39%), Gaps = 61/437 (13%)
Query: 163 EQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTD-KKDSGRLHVDFAQA 221
EQ ++ R++++N + E D+ I + G D KK L +
Sbjct: 1508 EQIRELEKDRETQRNVLEHQLLELEKKDQMI-----ESQRGQVQDLKKQLVTLECLALEL 1562
Query: 222 RDDFYEWECKQRMRAREERHRRK-----------LEEDRLRPPSPPAIMHYSEHEAALLA 270
++ ++ EC+Q++ E R LEE + + +H E + +LA
Sbjct: 1563 EENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLA 1622
Query: 271 EKLKDDSKFSEAITVLLSWIERG------EVNRRSANQFYSMVQSANSHVRRLMNEKATH 324
+L++ + ++ + ++R ++ RR M+Q V + T
Sbjct: 1623 RELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQEL---MLQKERIQVLEDQRTRQTK 1679
Query: 325 --EQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWR---KH 379
E+++E+ K + + + TQ + + R + SKAQR +++ + +
Sbjct: 1680 ILEEDLEQIKLSLRERGRELTTQRQLM------QERAEEGKGPSKAQRGSLEHMKLILRD 1733
Query: 380 SEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
E+ Q E + E E+ D +V E++L ++E L+ Q
Sbjct: 1734 KEKEVECQQEHI-----HELQELKDQLEQQLQGLHRKVGETSLLLSQR--EQEIVVLQQQ 1786
Query: 440 LDAYRNEVELLKQE-KEQLFRTEENLT-KDQQLQFLQQTMQGMQQQLLTIQEE------- 490
L R + EL +Q + QL + L +DQ+L+ LQQ Q Q Q ++E+
Sbjct: 1787 LQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGA 1846
Query: 491 -------LNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELV-ETNGHSHEDSNEINVL 542
L + EL+ KE+ + L V +++ +E++ + S E + L
Sbjct: 1847 LEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLAL 1906
Query: 543 TVALVNQDRENNIEKRS 559
Q +E+ +E R+
Sbjct: 1907 QQQCAEQAQEHEVETRA 1923
Score = 41.6 bits (96), Expect = 0.002
Identities = 88/379 (23%), Positives = 143/379 (37%), Gaps = 80/379 (21%)
Query: 199 RMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAI 258
R G K G L RD E EC+Q H +L+E + +
Sbjct: 1709 RAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQE-------HIHELQELKDQLEQQLQG 1761
Query: 259 MHYSEHEAALLAEKLKDDSKFSEAITVLLSWI----ERGEVNRRSANQFYSMVQSA---- 310
+H E +LL S+ + I VL + E+GE+ +S Q A
Sbjct: 1762 LHRKVGETSLLL------SQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQR 1815
Query: 311 NSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQR 370
+ + L E+ + + E KE +AL G L Q + + + DH +A+R
Sbjct: 1816 DQELEALQQEQQQAQGQEERVKEK-ADALQGALEQAHMTLKERHGELQ----DHKEQARR 1870
Query: 371 KNIDIWRKHSEELRNAQS-EQLMGIRREEEMEMSD-----DENCDSPTKKMRVD-----E 419
++ + E R Q+ E+++G R E E + C ++ V+ +
Sbjct: 1871 LEEEL----AVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQD 1926
Query: 420 SALAAQAY---------ALKEENDSLRWQLDAYRNEVELLK----------QEKEQLFRT 460
S L AQA AL+ E+ S R Q +A R E L+ Q KEQ
Sbjct: 1927 SWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLE 1986
Query: 461 EENLTKD-------------------QQLQFLQQTMQG-MQQQLLTIQEELNNKKSELEQ 500
+ L++ +QL+ + +G +Q Q L QE++ + L Q
Sbjct: 1987 QAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQ 2046
Query: 501 AKEEQSHTQALLKVLQEQL 519
EE H Q ++L++ L
Sbjct: 2047 RDEELRHQQEREQLLEKSL 2065
Score = 41.2 bits (95), Expect = 0.003
Identities = 51/255 (20%), Positives = 116/255 (45%), Gaps = 18/255 (7%)
Query: 326 QEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKA-WDHFSKAQRKNIDIWRKHSEELR 384
Q++EE + + + + T+ + + + + +K+ W+ K ++ H E +
Sbjct: 1267 QKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWE--GKQNSLESELMELH-ETMA 1323
Query: 385 NAQSE------QLMGIRREEEMEMSDDENCDSPTKKMR---VDESALAAQAYALKEENDS 435
+ QS Q M + E E+ + EN + + ++ V+ A A+ A L+E+ +
Sbjct: 1324 SLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRT 1383
Query: 436 LRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKK 495
R L EVE ++ + L E+ K Q + LQ+ + + Q L +EE+ +
Sbjct: 1384 ARSALKLKNEEVESERERAQAL--QEQGELKVAQGKALQENLALLTQTLAEREEEVETLR 1441
Query: 496 SELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLT--VALVNQDREN 553
++++ ++++ +A L++L LK + V+ ++ + + + + Q+RE
Sbjct: 1442 GQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQ 1501
Query: 554 NIE-KRSQGLKSEKE 567
+ +R Q + EK+
Sbjct: 1502 KLTVQREQIRELEKD 1516
Score = 40.8 bits (94), Expect = 0.004
Identities = 64/316 (20%), Positives = 132/316 (41%), Gaps = 34/316 (10%)
Query: 302 QFYSMVQSANSHVRR--LMNEKATHEQEM-EEAKENFKNALTGILTQFEQI-VAVFNAST 357
+ + + S S +RR L +A E+E+ + AKEN + Q E + AV A
Sbjct: 1317 ELHETMASLQSRLRRAELQRMEAQGERELLQAAKEN-------LTAQVEHLQAAVVEARA 1369
Query: 358 RQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRV 417
+ A + R + +EE+ + + E+ ++ + E++++ K
Sbjct: 1370 QASAAGILEEDLRTARSALKLKNEEVES-ERERAQALQEQGELKVAQG--------KALQ 1420
Query: 418 DESALAAQAYALKEEN-DSLRWQLDAYRNEVELLKQEKEQLF-----RTEENLTKDQQLQ 471
+ AL Q A +EE ++LR Q+ + E+ K E L R +E + +Q+Q
Sbjct: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
Query: 472 FLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQ---LKGTKELVET 528
L++ ++ + +QE + EQ +E + + VL+ Q L+ +++E+
Sbjct: 1481 ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIES 1540
Query: 529 NGHSHEDSNEINVLTVALVNQDRENN-----IEKRSQGLKSEKEALLIGIISTFLHVHPF 583
+D + V L + EN+ +K + L+ ++E + + L +
Sbjct: 1541 QRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEER 1600
Query: 584 GANIEYLWSYMQQLDS 599
++ S + L+S
Sbjct: 1601 SQELQAQSSQIHDLES 1616
Score = 39.3 bits (90), Expect = 0.011
Identities = 67/328 (20%), Positives = 125/328 (38%), Gaps = 52/328 (15%)
Query: 263 EHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKA 322
+ E + +KL + EA T L + + A + ++ A L+ EKA
Sbjct: 686 QEEKEEIQKKLSESRHQQEAATTQLEQLHQ------EAKRQEEVLARAVQEKEALVREKA 739
Query: 323 THE---QEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKH 379
E Q +E +++ L G+ + E + + + +Q + +K Q +++ +
Sbjct: 740 ALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ---LEVQIQT 796
Query: 380 SEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQ-AYALKEENDSLRW 438
+ + ++ ++ E + E S E + A A Q A A +E +L
Sbjct: 797 VTQAKEVIQGEVRCLKLELDTERSQAEQ----------ERDAAARQLAQAEQEGKTALEQ 846
Query: 439 QLDAYRNEVELLKQ--EKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKS 496
Q A+ EV L++ EKE+ + QQ+L E L +K
Sbjct: 847 QKAAHEKEVNQLREKWEKERSWH---------------------QQELAKALESLEREKM 885
Query: 497 ELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQ----DRE 552
ELE +EQ ++ +E+ + E + +++L L Q D
Sbjct: 886 ELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADAS 945
Query: 553 NNIEKRSQGLKSE--KEALLIGIISTFL 578
+E+ Q +K + KE GI+ T L
Sbjct: 946 QQLERLRQDMKVQKLKEQETTGILQTQL 973
Score = 36.6 bits (83), Expect = 0.073
Identities = 55/273 (20%), Positives = 116/273 (42%), Gaps = 46/273 (16%)
Query: 326 QEMEEAKENFKNALTGILTQFEQIVAVFNASTRQ---------------KAWDHFSKAQR 370
+E+E +E + ALT + E+ A + Q + D K+QR
Sbjct: 1577 KELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQR 1636
Query: 371 KNIDIWRKHSEELRN---AQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAY 427
+ I+ ++ E L + ++LM ++E +++ +D+ T++ ++ E L
Sbjct: 1637 EQIEELQRQKEHLTQDLERRDQELM--LQKERIQVLEDQR----TRQTKILEEDLEQIKL 1690
Query: 428 ALKEENDSLRWQLDAYRNEVELLK----------QEKEQLFRTEENLTKDQQ--LQFLQQ 475
+L+E L Q + E K + + + R +E + QQ + LQ+
Sbjct: 1691 SLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQE 1750
Query: 476 TMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHED 535
++QQL + ++ L Q ++E + VLQ+QL+ +E E S +
Sbjct: 1751 LKDQLEQQLQGLHRKVGETSLLLSQREQE-------IVVLQQQLQEAREQGELKEQSLQ- 1802
Query: 536 SNEINVLTVALVNQDRE-NNIEKRSQGLKSEKE 567
++++ AL +D+E +++ Q + ++E
Sbjct: 1803 -SQLDEAQRALAQRDQELEALQQEQQQAQGQEE 1834
Score = 34.7 bits (78), Expect = 0.28
Identities = 57/252 (22%), Positives = 109/252 (43%), Gaps = 41/252 (16%)
Query: 263 EHEAALLA--EKLKDDSKFSEAITVLL--SWIERGEVNRRSANQFYSMVQSANSHVRRLM 318
E E ALLA ++ + ++ E T L SW++ V + + ++ A S R
Sbjct: 1898 EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEAL--RAESQSSRHQ 1955
Query: 319 NEKATHEQE-MEEAKENFKNALTGI---LTQFEQIVAVFNASTRQKAWDHFSKAQRKNID 374
E A E ++EA AL G L + ++ AST + ++D
Sbjct: 1956 EEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTA---------TLQASLD 2006
Query: 375 IWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEEND 434
+ HS +L A R +E E+ D + +R E Q AL + ++
Sbjct: 2007 ACQAHSRQLEEAL--------RIQEGEIQDQD--------LRYQEDVQQLQQ-ALAQRDE 2049
Query: 435 SLRWQLDAYRN-EVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNN 493
LR Q + + E L ++ +E + + ++NL ++++ ++ ++G+ Q + +Q L
Sbjct: 2050 ELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQERE----EEEIRGLHQSVRELQLTLAQ 2105
Query: 494 KKSELEQAKEEQ 505
K+ E+ + +E Q
Sbjct: 2106 KEQEILELRETQ 2117
Score = 30.8 bits (68), Expect = 4.0
Identities = 62/322 (19%), Positives = 128/322 (39%), Gaps = 36/322 (11%)
Query: 229 ECKQRMRAREERHRRKLEE--DRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVL 286
+ K ++ A+++ R +E ++LR Y+ + L EK E L
Sbjct: 1014 DLKSQLVAQDDSQRLVEQEVQEKLRETQ-----EYNRIQKELEREKASLTLSLMEKEQRL 1068
Query: 287 LSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQF 346
L E + ++ + +Q A + L + QE++E + +F +L +
Sbjct: 1069 LVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEEL 1128
Query: 347 EQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSD-- 404
E + R W +KA + + + R +L +EQ G + + + +++
Sbjct: 1129 EAS-HITEQQLRASLWAQEAKAAQLQLRL-RSTESQLEALAAEQQPGNQAQAQAQLASLY 1186
Query: 405 -------DENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ------LDAYRNEV--EL 449
C+S + +SA + L+ + + R L A E
Sbjct: 1187 SALQQALGSVCESRPELSGGGDSA--PSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244
Query: 450 LKQEKEQLFRTEENLTKD---QQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQS 506
L + + L++T++ T+D Q+Q L++ + + + + EL + + +L Q +EE+S
Sbjct: 1245 LHKLHQDLWKTQQ--TRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS 1302
Query: 507 HTQALLKVLQEQLKGTKELVET 528
+ L+ +L EL ET
Sbjct: 1303 KWEGKQNSLESEL---MELHET 1321
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 53.9 bits (128), Expect = 4e-07
Identities = 76/344 (22%), Positives = 143/344 (41%), Gaps = 43/344 (12%)
Query: 231 KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
+QR A EE RR+ E+R++ S A + A L E + +K EA +
Sbjct: 1971 RQRQLAAEEERRRREAEERVQK-SLAAEEEAARQRKAALEEVERLKAKVEEARRL----- 2024
Query: 291 ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
R + SA Q ++A +RL E+ H +++ ++ + L + +Q+
Sbjct: 2025 -RERAEQESARQLQLAQEAAQ---KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Query: 351 AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ-SEQLMGIRREEEMEMSDDENCD 409
A+ R +A+ + R+ ++ R + +E+L E+ + +
Sbjct: 2081 GEAEAARRAA-----EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135
Query: 410 SPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQ 469
+K E+A AQA E +LR Q A E+E K+ EQ R + + +Q+
Sbjct: 2136 EKLRKEAEQEAARRAQA-----EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQV--EQE 2187
Query: 470 LQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALL---KVLQEQLKGTKELV 526
L L+ ++ Q + EEL K+E +A ++S + L +V E+L K +
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2247
Query: 527 ETNGHSHEDSNEINVLTVALVNQDRENN---IEKRSQGLKSEKE 567
E AL+ +D++N +++ ++ +K E
Sbjct: 2248 EAENR-------------ALILRDKDNTQRFLQEEAEKMKQVAE 2278
Score = 51.6 bits (122), Expect = 2e-06
Identities = 76/344 (22%), Positives = 144/344 (41%), Gaps = 20/344 (5%)
Query: 229 ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
E +R R E + L R R A ++ EA L +++D+S+ V L+
Sbjct: 1462 EATERQRGGAEGELQAL---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518
Query: 289 WIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATH---EQEMEEAKENFKNALTGILTQ 345
R + +A + +Q+ RL E+A + E+E A++ + AL
Sbjct: 1519 --SRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQ-VQVALETAQRS 1573
Query: 346 FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSE-QLMGIRREEEMEMSD 404
E + AS +K Q +++ + + E R AQ + + R E E E+
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Query: 405 DENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL 464
+ + ++R+ +A Q + E + Q + E + +EQ R E
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRE-- 1688
Query: 465 TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE-QSHTQALLKVLQEQLKGTK 523
+Q+L+ +Q +G QQ L ++EL ++E EQ +++ Q + L ++ +E T+
Sbjct: 1689 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1748
Query: 524 ELVETNGHSHEDSNEINVL--TVALVNQDRENNIEKRSQGLKSE 565
+ E + E+ VL + A ++ + EK Q L++E
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792
Score = 43.1 bits (100), Expect = 8e-04
Identities = 69/328 (21%), Positives = 137/328 (41%), Gaps = 50/328 (15%)
Query: 279 FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRR-------LMNEKATHEQEMEEA 331
+ E+ L +W++ RR Q +M + + VR L+ E H +++EE
Sbjct: 1212 YRESADPLGAWLQDA---RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1268
Query: 332 KENFKNALTGI-------LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
+ K + I +T Q+ V + + + K ++ +D+ R H EL
Sbjct: 1269 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL-RTHYSELT 1327
Query: 385 NAQSEQLMGI-----RREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
S+ + I R EEE +++ + + + V E+AL Q L E + + Q
Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV-EAALEKQRQ-LAEAHAQAKAQ 1385
Query: 440 LDAYRNEVELLKQEKEQLFRTEEN-LTKDQQLQFLQQTMQGMQQQL-------------- 484
A R EL ++ +E++ R EE + QQ + +Q+ +Q ++Q
Sbjct: 1386 --AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1443
Query: 485 ----LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
L I+EE+ + +LE + ++ + L+ L+ + +E + E++ +
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEAQKRQAQEEAERLR 1500
Query: 541 VLTVALVNQDRENNIEKRSQGLKSEKEA 568
+ R+ +E S+ +K+E EA
Sbjct: 1501 RQVQDESQRKRQAEVELASR-VKAEAEA 1527
Score = 42.4 bits (98), Expect = 0.001
Identities = 74/354 (20%), Positives = 135/354 (38%), Gaps = 30/354 (8%)
Query: 231 KQRMRAREERHRRKLEED-RLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSW 289
KQR+ A R R EE RLR + A E ++ + + +E + +
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1842
Query: 290 IERGEVNRRSANQFYSMVQ--SANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
GE R ++ + + N +RRL ++A + +EE K + L Q
Sbjct: 1843 ---GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899
Query: 348 QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL--RNAQSEQLMGIRREEEMEMSDD 405
+ A + RQK + QR+ ++ EE+ A E+ + E E+E+
Sbjct: 1900 K--ASDSELERQKGLVEDTLRQRRQVE------EEILALKASFEKAAAGKAELELELGRI 1951
Query: 406 ENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLD-----AYRNEVELLKQEKEQLFRT 460
+ T + + AA+ L E + R + + + E E +Q K L
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 461 EENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQ---AKEEQSHTQALLKVLQE 517
E K ++ + L++ + + L + +E K+ + E+ A Q Q L + LQ+
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071
Query: 518 QLKGTKEL---VETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
+ +L E + E++ E V Q R E +E++A
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125
Score = 41.6 bits (96), Expect = 0.002
Identities = 98/425 (23%), Positives = 177/425 (41%), Gaps = 57/425 (13%)
Query: 233 RMRAREERHRRKL---EEDRLRPPSPPAIMHYSEHEAALLAEKLKDD--SKFS---EAIT 284
R++ E H++ L E RL+ + A S+ E L + +++ + SK EA
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2251
Query: 285 VLLSWIERGEVNRRSANQFYSMVQSANSHVR-RLMNEKATHEQEMEEAKENFKNALTGIL 343
L ++ R + M Q A R + ++A +++ E + AL +
Sbjct: 2252 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311
Query: 344 TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL----MGIRR--E 397
+ E++ AV A TR KA + Q++ + +E + ++QL G +R E
Sbjct: 2312 LK-EKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2369
Query: 398 EEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQL 457
E + + + ++ K+RV E + AQA A E D+ R++ A ++ E+L
Sbjct: 2370 AERQRQLEMSAEAERLKLRVAEMS-RAQARA---EEDAQRFRKQA--------EEIGEKL 2417
Query: 458 FRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLK---- 513
RTE Q+ L QT++ +QQ E L +ELE+ KE+ LL+
Sbjct: 2418 HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474
Query: 514 ----VLQEQLKGTKELVETNGHSHEDS---------------NEINVLTVALVNQDRENN 554
V QEQL + ++ + S +DS ++ VA Q RE
Sbjct: 2475 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2534
Query: 555 IEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLP 614
+++ Q ++ E++ L+ + H + +QQL+ + E E+L
Sbjct: 2535 -QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQ 2592
Query: 615 RMFKQ 619
R+ +Q
Sbjct: 2593 RLREQ 2597
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 53.9 bits (128), Expect = 4e-07
Identities = 76/344 (22%), Positives = 143/344 (41%), Gaps = 43/344 (12%)
Query: 231 KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
+QR A EE RR+ E+R++ S A + A L E + +K EA +
Sbjct: 1975 RQRQLAAEEERRRREAEERVQK-SLAAEEEAARQRKAALEEVERLKAKVEEARRL----- 2028
Query: 291 ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
R + SA Q ++A +RL E+ H +++ ++ + L + +Q+
Sbjct: 2029 -RERAEQESARQLQLAQEAAQ---KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2084
Query: 351 AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ-SEQLMGIRREEEMEMSDDENCD 409
A+ R +A+ + R+ ++ R + +E+L E+ + +
Sbjct: 2085 GEAEAARRAA-----EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2139
Query: 410 SPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQ 469
+K E+A AQA E +LR Q A E+E K+ EQ R + + +Q+
Sbjct: 2140 EKLRKEAEQEAARRAQA-----EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQV--EQE 2191
Query: 470 LQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALL---KVLQEQLKGTKELV 526
L L+ ++ Q + EEL K+E +A ++S + L +V E+L K +
Sbjct: 2192 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2251
Query: 527 ETNGHSHEDSNEINVLTVALVNQDRENN---IEKRSQGLKSEKE 567
E AL+ +D++N +++ ++ +K E
Sbjct: 2252 EAENR-------------ALILRDKDNTQRFLQEEAEKMKQVAE 2282
Score = 51.6 bits (122), Expect = 2e-06
Identities = 76/344 (22%), Positives = 144/344 (41%), Gaps = 20/344 (5%)
Query: 229 ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
E +R R E + L R R A ++ EA L +++D+S+ V L+
Sbjct: 1466 EATERQRGGAEGELQAL---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1522
Query: 289 WIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATH---EQEMEEAKENFKNALTGILTQ 345
R + +A + +Q+ RL E+A + E+E A++ + AL
Sbjct: 1523 --SRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQ-VQVALETAQRS 1577
Query: 346 FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSE-QLMGIRREEEMEMSD 404
E + AS +K Q +++ + + E R AQ + + R E E E+
Sbjct: 1578 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1637
Query: 405 DENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL 464
+ + ++R+ +A Q + E + Q + E + +EQ R E
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRE-- 1692
Query: 465 TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE-QSHTQALLKVLQEQLKGTK 523
+Q+L+ +Q +G QQ L ++EL ++E EQ +++ Q + L ++ +E T+
Sbjct: 1693 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1752
Query: 524 ELVETNGHSHEDSNEINVL--TVALVNQDRENNIEKRSQGLKSE 565
+ E + E+ VL + A ++ + EK Q L++E
Sbjct: 1753 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1796
Score = 43.1 bits (100), Expect = 8e-04
Identities = 69/328 (21%), Positives = 137/328 (41%), Gaps = 50/328 (15%)
Query: 279 FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRR-------LMNEKATHEQEMEEA 331
+ E+ L +W++ RR Q +M + + VR L+ E H +++EE
Sbjct: 1216 YRESADPLGAWLQDA---RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1272
Query: 332 KENFKNALTGI-------LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
+ K + I +T Q+ V + + + K ++ +D+ R H EL
Sbjct: 1273 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL-RTHYSELT 1331
Query: 385 NAQSEQLMGI-----RREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
S+ + I R EEE +++ + + + V E+AL Q L E + + Q
Sbjct: 1332 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV-EAALEKQRQ-LAEAHAQAKAQ 1389
Query: 440 LDAYRNEVELLKQEKEQLFRTEEN-LTKDQQLQFLQQTMQGMQQQL-------------- 484
A R EL ++ +E++ R EE + QQ + +Q+ +Q ++Q
Sbjct: 1390 --AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1447
Query: 485 ----LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
L I+EE+ + +LE + ++ + L+ L+ + +E + E++ +
Sbjct: 1448 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEAQKRQAQEEAERLR 1504
Query: 541 VLTVALVNQDRENNIEKRSQGLKSEKEA 568
+ R+ +E S+ +K+E EA
Sbjct: 1505 RQVQDESQRKRQAEVELASR-VKAEAEA 1531
Score = 42.4 bits (98), Expect = 0.001
Identities = 74/354 (20%), Positives = 135/354 (38%), Gaps = 30/354 (8%)
Query: 231 KQRMRAREERHRRKLEED-RLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSW 289
KQR+ A R R EE RLR + A E ++ + + +E + +
Sbjct: 1790 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1846
Query: 290 IERGEVNRRSANQFYSMVQ--SANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
GE R ++ + + N +RRL ++A + +EE K + L Q
Sbjct: 1847 ---GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1903
Query: 348 QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL--RNAQSEQLMGIRREEEMEMSDD 405
+ A + RQK + QR+ ++ EE+ A E+ + E E+E+
Sbjct: 1904 K--ASDSELERQKGLVEDTLRQRRQVE------EEILALKASFEKAAAGKAELELELGRI 1955
Query: 406 ENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLD-----AYRNEVELLKQEKEQLFRT 460
+ T + + AA+ L E + R + + + E E +Q K L
Sbjct: 1956 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2015
Query: 461 EENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQ---AKEEQSHTQALLKVLQE 517
E K ++ + L++ + + L + +E K+ + E+ A Q Q L + LQ+
Sbjct: 2016 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2075
Query: 518 QLKGTKEL---VETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
+ +L E + E++ E V Q R E +E++A
Sbjct: 2076 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2129
Score = 41.6 bits (96), Expect = 0.002
Identities = 98/425 (23%), Positives = 177/425 (41%), Gaps = 57/425 (13%)
Query: 233 RMRAREERHRRKL---EEDRLRPPSPPAIMHYSEHEAALLAEKLKDD--SKFS---EAIT 284
R++ E H++ L E RL+ + A S+ E L + +++ + SK EA
Sbjct: 2196 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2255
Query: 285 VLLSWIERGEVNRRSANQFYSMVQSANSHVR-RLMNEKATHEQEMEEAKENFKNALTGIL 343
L ++ R + M Q A R + ++A +++ E + AL +
Sbjct: 2256 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2315
Query: 344 TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL----MGIRR--E 397
+ E++ AV A TR KA + Q++ + +E + ++QL G +R E
Sbjct: 2316 LK-EKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2373
Query: 398 EEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQL 457
E + + + ++ K+RV E + AQA A E D+ R++ A ++ E+L
Sbjct: 2374 AERQRQLEMSAEAERLKLRVAEMS-RAQARA---EEDAQRFRKQA--------EEIGEKL 2421
Query: 458 FRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLK---- 513
RTE Q+ L QT++ +QQ E L +ELE+ KE+ LL+
Sbjct: 2422 HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2478
Query: 514 ----VLQEQLKGTKELVETNGHSHEDS---------------NEINVLTVALVNQDRENN 554
V QEQL + ++ + S +DS ++ VA Q RE
Sbjct: 2479 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2538
Query: 555 IEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLP 614
+++ Q ++ E++ L+ + H + +QQL+ + E E+L
Sbjct: 2539 -QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQ 2596
Query: 615 RMFKQ 619
R+ +Q
Sbjct: 2597 RLREQ 2601
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 53.9 bits (128), Expect = 4e-07
Identities = 76/344 (22%), Positives = 143/344 (41%), Gaps = 43/344 (12%)
Query: 231 KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
+QR A EE RR+ E+R++ S A + A L E + +K EA +
Sbjct: 1971 RQRQLAAEEERRRREAEERVQK-SLAAEEEAARQRKAALEEVERLKAKVEEARRL----- 2024
Query: 291 ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
R + SA Q ++A +RL E+ H +++ ++ + L + +Q+
Sbjct: 2025 -RERAEQESARQLQLAQEAAQ---KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Query: 351 AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ-SEQLMGIRREEEMEMSDDENCD 409
A+ R +A+ + R+ ++ R + +E+L E+ + +
Sbjct: 2081 GEAEAARRAA-----EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135
Query: 410 SPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQ 469
+K E+A AQA E +LR Q A E+E K+ EQ R + + +Q+
Sbjct: 2136 EKLRKEAEQEAARRAQA-----EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQV--EQE 2187
Query: 470 LQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALL---KVLQEQLKGTKELV 526
L L+ ++ Q + EEL K+E +A ++S + L +V E+L K +
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2247
Query: 527 ETNGHSHEDSNEINVLTVALVNQDRENN---IEKRSQGLKSEKE 567
E AL+ +D++N +++ ++ +K E
Sbjct: 2248 EAENR-------------ALILRDKDNTQRFLQEEAEKMKQVAE 2278
Score = 51.6 bits (122), Expect = 2e-06
Identities = 76/344 (22%), Positives = 144/344 (41%), Gaps = 20/344 (5%)
Query: 229 ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
E +R R E + L R R A ++ EA L +++D+S+ V L+
Sbjct: 1462 EATERQRGGAEGELQAL---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518
Query: 289 WIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATH---EQEMEEAKENFKNALTGILTQ 345
R + +A + +Q+ RL E+A + E+E A++ + AL
Sbjct: 1519 --SRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQ-VQVALETAQRS 1573
Query: 346 FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSE-QLMGIRREEEMEMSD 404
E + AS +K Q +++ + + E R AQ + + R E E E+
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Query: 405 DENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL 464
+ + ++R+ +A Q + E + Q + E + +EQ R E
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRE-- 1688
Query: 465 TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE-QSHTQALLKVLQEQLKGTK 523
+Q+L+ +Q +G QQ L ++EL ++E EQ +++ Q + L ++ +E T+
Sbjct: 1689 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1748
Query: 524 ELVETNGHSHEDSNEINVL--TVALVNQDRENNIEKRSQGLKSE 565
+ E + E+ VL + A ++ + EK Q L++E
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792
Score = 43.1 bits (100), Expect = 8e-04
Identities = 69/328 (21%), Positives = 137/328 (41%), Gaps = 50/328 (15%)
Query: 279 FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRR-------LMNEKATHEQEMEEA 331
+ E+ L +W++ RR Q +M + + VR L+ E H +++EE
Sbjct: 1212 YRESADPLGAWLQDA---RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1268
Query: 332 KENFKNALTGI-------LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
+ K + I +T Q+ V + + + K ++ +D+ R H EL
Sbjct: 1269 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL-RTHYSELT 1327
Query: 385 NAQSEQLMGI-----RREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
S+ + I R EEE +++ + + + V E+AL Q L E + + Q
Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV-EAALEKQRQ-LAEAHAQAKAQ 1385
Query: 440 LDAYRNEVELLKQEKEQLFRTEEN-LTKDQQLQFLQQTMQGMQQQL-------------- 484
A R EL ++ +E++ R EE + QQ + +Q+ +Q ++Q
Sbjct: 1386 --AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1443
Query: 485 ----LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
L I+EE+ + +LE + ++ + L+ L+ + +E + E++ +
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEAQKRQAQEEAERLR 1500
Query: 541 VLTVALVNQDRENNIEKRSQGLKSEKEA 568
+ R+ +E S+ +K+E EA
Sbjct: 1501 RQVQDESQRKRQAEVELASR-VKAEAEA 1527
Score = 42.4 bits (98), Expect = 0.001
Identities = 74/354 (20%), Positives = 135/354 (38%), Gaps = 30/354 (8%)
Query: 231 KQRMRAREERHRRKLEED-RLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSW 289
KQR+ A R R EE RLR + A E ++ + + +E + +
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1842
Query: 290 IERGEVNRRSANQFYSMVQ--SANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
GE R ++ + + N +RRL ++A + +EE K + L Q
Sbjct: 1843 ---GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899
Query: 348 QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL--RNAQSEQLMGIRREEEMEMSDD 405
+ A + RQK + QR+ ++ EE+ A E+ + E E+E+
Sbjct: 1900 K--ASDSELERQKGLVEDTLRQRRQVE------EEILALKASFEKAAAGKAELELELGRI 1951
Query: 406 ENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLD-----AYRNEVELLKQEKEQLFRT 460
+ T + + AA+ L E + R + + + E E +Q K L
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 461 EENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQ---AKEEQSHTQALLKVLQE 517
E K ++ + L++ + + L + +E K+ + E+ A Q Q L + LQ+
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071
Query: 518 QLKGTKEL---VETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
+ +L E + E++ E V Q R E +E++A
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125
Score = 41.6 bits (96), Expect = 0.002
Identities = 98/425 (23%), Positives = 177/425 (41%), Gaps = 57/425 (13%)
Query: 233 RMRAREERHRRKL---EEDRLRPPSPPAIMHYSEHEAALLAEKLKDD--SKFS---EAIT 284
R++ E H++ L E RL+ + A S+ E L + +++ + SK EA
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2251
Query: 285 VLLSWIERGEVNRRSANQFYSMVQSANSHVR-RLMNEKATHEQEMEEAKENFKNALTGIL 343
L ++ R + M Q A R + ++A +++ E + AL +
Sbjct: 2252 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311
Query: 344 TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL----MGIRR--E 397
+ E++ AV A TR KA + Q++ + +E + ++QL G +R E
Sbjct: 2312 LK-EKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2369
Query: 398 EEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQL 457
E + + + ++ K+RV E + AQA A E D+ R++ A ++ E+L
Sbjct: 2370 AERQRQLEMSAEAERLKLRVAEMS-RAQARA---EEDAQRFRKQA--------EEIGEKL 2417
Query: 458 FRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLK---- 513
RTE Q+ L QT++ +QQ E L +ELE+ KE+ LL+
Sbjct: 2418 HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474
Query: 514 ----VLQEQLKGTKELVETNGHSHEDS---------------NEINVLTVALVNQDRENN 554
V QEQL + ++ + S +DS ++ VA Q RE
Sbjct: 2475 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2534
Query: 555 IEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLP 614
+++ Q ++ E++ L+ + H + +QQL+ + E E+L
Sbjct: 2535 -QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQ 2592
Query: 615 RMFKQ 619
R+ +Q
Sbjct: 2593 RLREQ 2597
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 53.9 bits (128), Expect = 4e-07
Identities = 76/344 (22%), Positives = 143/344 (41%), Gaps = 43/344 (12%)
Query: 231 KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
+QR A EE RR+ E+R++ S A + A L E + +K EA +
Sbjct: 1939 RQRQLAAEEERRRREAEERVQK-SLAAEEEAARQRKAALEEVERLKAKVEEARRL----- 1992
Query: 291 ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
R + SA Q ++A +RL E+ H +++ ++ + L + +Q+
Sbjct: 1993 -RERAEQESARQLQLAQEAAQ---KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2048
Query: 351 AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ-SEQLMGIRREEEMEMSDDENCD 409
A+ R +A+ + R+ ++ R + +E+L E+ + +
Sbjct: 2049 GEAEAARRAA-----EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2103
Query: 410 SPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQ 469
+K E+A AQA E +LR Q A E+E K+ EQ R + + +Q+
Sbjct: 2104 EKLRKEAEQEAARRAQA-----EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQV--EQE 2155
Query: 470 LQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALL---KVLQEQLKGTKELV 526
L L+ ++ Q + EEL K+E +A ++S + L +V E+L K +
Sbjct: 2156 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2215
Query: 527 ETNGHSHEDSNEINVLTVALVNQDRENN---IEKRSQGLKSEKE 567
E AL+ +D++N +++ ++ +K E
Sbjct: 2216 EAENR-------------ALILRDKDNTQRFLQEEAEKMKQVAE 2246
Score = 51.6 bits (122), Expect = 2e-06
Identities = 76/344 (22%), Positives = 144/344 (41%), Gaps = 20/344 (5%)
Query: 229 ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
E +R R E + L R R A ++ EA L +++D+S+ V L+
Sbjct: 1430 EATERQRGGAEGELQAL---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1486
Query: 289 WIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATH---EQEMEEAKENFKNALTGILTQ 345
R + +A + +Q+ RL E+A + E+E A++ + AL
Sbjct: 1487 --SRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQ-VQVALETAQRS 1541
Query: 346 FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSE-QLMGIRREEEMEMSD 404
E + AS +K Q +++ + + E R AQ + + R E E E+
Sbjct: 1542 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601
Query: 405 DENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL 464
+ + ++R+ +A Q + E + Q + E + +EQ R E
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRE-- 1656
Query: 465 TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE-QSHTQALLKVLQEQLKGTK 523
+Q+L+ +Q +G QQ L ++EL ++E EQ +++ Q + L ++ +E T+
Sbjct: 1657 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1716
Query: 524 ELVETNGHSHEDSNEINVL--TVALVNQDRENNIEKRSQGLKSE 565
+ E + E+ VL + A ++ + EK Q L++E
Sbjct: 1717 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1760
Score = 43.1 bits (100), Expect = 8e-04
Identities = 69/328 (21%), Positives = 137/328 (41%), Gaps = 50/328 (15%)
Query: 279 FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRR-------LMNEKATHEQEMEEA 331
+ E+ L +W++ RR Q +M + + VR L+ E H +++EE
Sbjct: 1180 YRESADPLGAWLQDA---RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1236
Query: 332 KENFKNALTGI-------LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
+ K + I +T Q+ V + + + K ++ +D+ R H EL
Sbjct: 1237 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL-RTHYSELT 1295
Query: 385 NAQSEQLMGI-----RREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
S+ + I R EEE +++ + + + V E+AL Q L E + + Q
Sbjct: 1296 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV-EAALEKQRQ-LAEAHAQAKAQ 1353
Query: 440 LDAYRNEVELLKQEKEQLFRTEEN-LTKDQQLQFLQQTMQGMQQQL-------------- 484
A R EL ++ +E++ R EE + QQ + +Q+ +Q ++Q
Sbjct: 1354 --AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1411
Query: 485 ----LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
L I+EE+ + +LE + ++ + L+ L+ + +E + E++ +
Sbjct: 1412 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEAQKRQAQEEAERLR 1468
Query: 541 VLTVALVNQDRENNIEKRSQGLKSEKEA 568
+ R+ +E S+ +K+E EA
Sbjct: 1469 RQVQDESQRKRQAEVELASR-VKAEAEA 1495
Score = 42.4 bits (98), Expect = 0.001
Identities = 74/354 (20%), Positives = 135/354 (38%), Gaps = 30/354 (8%)
Query: 231 KQRMRAREERHRRKLEED-RLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSW 289
KQR+ A R R EE RLR + A E ++ + + +E + +
Sbjct: 1754 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1810
Query: 290 IERGEVNRRSANQFYSMVQ--SANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
GE R ++ + + N +RRL ++A + +EE K + L Q
Sbjct: 1811 ---GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1867
Query: 348 QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL--RNAQSEQLMGIRREEEMEMSDD 405
+ A + RQK + QR+ ++ EE+ A E+ + E E+E+
Sbjct: 1868 K--ASDSELERQKGLVEDTLRQRRQVE------EEILALKASFEKAAAGKAELELELGRI 1919
Query: 406 ENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLD-----AYRNEVELLKQEKEQLFRT 460
+ T + + AA+ L E + R + + + E E +Q K L
Sbjct: 1920 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1979
Query: 461 EENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQ---AKEEQSHTQALLKVLQE 517
E K ++ + L++ + + L + +E K+ + E+ A Q Q L + LQ+
Sbjct: 1980 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2039
Query: 518 QLKGTKEL---VETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
+ +L E + E++ E V Q R E +E++A
Sbjct: 2040 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2093
Score = 41.6 bits (96), Expect = 0.002
Identities = 98/425 (23%), Positives = 177/425 (41%), Gaps = 57/425 (13%)
Query: 233 RMRAREERHRRKL---EEDRLRPPSPPAIMHYSEHEAALLAEKLKDD--SKFS---EAIT 284
R++ E H++ L E RL+ + A S+ E L + +++ + SK EA
Sbjct: 2160 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2219
Query: 285 VLLSWIERGEVNRRSANQFYSMVQSANSHVR-RLMNEKATHEQEMEEAKENFKNALTGIL 343
L ++ R + M Q A R + ++A +++ E + AL +
Sbjct: 2220 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2279
Query: 344 TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL----MGIRR--E 397
+ E++ AV A TR KA + Q++ + +E + ++QL G +R E
Sbjct: 2280 LK-EKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2337
Query: 398 EEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQL 457
E + + + ++ K+RV E + AQA A E D+ R++ A ++ E+L
Sbjct: 2338 AERQRQLEMSAEAERLKLRVAEMS-RAQARA---EEDAQRFRKQA--------EEIGEKL 2385
Query: 458 FRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLK---- 513
RTE Q+ L QT++ +QQ E L +ELE+ KE+ LL+
Sbjct: 2386 HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2442
Query: 514 ----VLQEQLKGTKELVETNGHSHEDS---------------NEINVLTVALVNQDRENN 554
V QEQL + ++ + S +DS ++ VA Q RE
Sbjct: 2443 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2502
Query: 555 IEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLP 614
+++ Q ++ E++ L+ + H + +QQL+ + E E+L
Sbjct: 2503 -QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQ 2560
Query: 615 RMFKQ 619
R+ +Q
Sbjct: 2561 RLREQ 2565
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 53.9 bits (128), Expect = 4e-07
Identities = 76/344 (22%), Positives = 143/344 (41%), Gaps = 43/344 (12%)
Query: 231 KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
+QR A EE RR+ E+R++ S A + A L E + +K EA +
Sbjct: 2108 RQRQLAAEEERRRREAEERVQK-SLAAEEEAARQRKAALEEVERLKAKVEEARRL----- 2161
Query: 291 ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
R + SA Q ++A +RL E+ H +++ ++ + L + +Q+
Sbjct: 2162 -RERAEQESARQLQLAQEAAQ---KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2217
Query: 351 AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ-SEQLMGIRREEEMEMSDDENCD 409
A+ R +A+ + R+ ++ R + +E+L E+ + +
Sbjct: 2218 GEAEAARRAA-----EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2272
Query: 410 SPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQ 469
+K E+A AQA E +LR Q A E+E K+ EQ R + + +Q+
Sbjct: 2273 EKLRKEAEQEAARRAQA-----EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQV--EQE 2324
Query: 470 LQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALL---KVLQEQLKGTKELV 526
L L+ ++ Q + EEL K+E +A ++S + L +V E+L K +
Sbjct: 2325 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2384
Query: 527 ETNGHSHEDSNEINVLTVALVNQDRENN---IEKRSQGLKSEKE 567
E AL+ +D++N +++ ++ +K E
Sbjct: 2385 EAENR-------------ALILRDKDNTQRFLQEEAEKMKQVAE 2415
Score = 51.6 bits (122), Expect = 2e-06
Identities = 76/344 (22%), Positives = 144/344 (41%), Gaps = 20/344 (5%)
Query: 229 ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
E +R R E + L R R A ++ EA L +++D+S+ V L+
Sbjct: 1599 EATERQRGGAEGELQAL---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1655
Query: 289 WIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATH---EQEMEEAKENFKNALTGILTQ 345
R + +A + +Q+ RL E+A + E+E A++ + AL
Sbjct: 1656 --SRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQ-VQVALETAQRS 1710
Query: 346 FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSE-QLMGIRREEEMEMSD 404
E + AS +K Q +++ + + E R AQ + + R E E E+
Sbjct: 1711 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770
Query: 405 DENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL 464
+ + ++R+ +A Q + E + Q + E + +EQ R E
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRE-- 1825
Query: 465 TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE-QSHTQALLKVLQEQLKGTK 523
+Q+L+ +Q +G QQ L ++EL ++E EQ +++ Q + L ++ +E T+
Sbjct: 1826 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1885
Query: 524 ELVETNGHSHEDSNEINVL--TVALVNQDRENNIEKRSQGLKSE 565
+ E + E+ VL + A ++ + EK Q L++E
Sbjct: 1886 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1929
Score = 43.1 bits (100), Expect = 8e-04
Identities = 69/328 (21%), Positives = 137/328 (41%), Gaps = 50/328 (15%)
Query: 279 FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRR-------LMNEKATHEQEMEEA 331
+ E+ L +W++ RR Q +M + + VR L+ E H +++EE
Sbjct: 1349 YRESADPLGAWLQDA---RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1405
Query: 332 KENFKNALTGI-------LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
+ K + I +T Q+ V + + + K ++ +D+ R H EL
Sbjct: 1406 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL-RTHYSELT 1464
Query: 385 NAQSEQLMGI-----RREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
S+ + I R EEE +++ + + + V E+AL Q L E + + Q
Sbjct: 1465 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV-EAALEKQRQ-LAEAHAQAKAQ 1522
Query: 440 LDAYRNEVELLKQEKEQLFRTEEN-LTKDQQLQFLQQTMQGMQQQL-------------- 484
A R EL ++ +E++ R EE + QQ + +Q+ +Q ++Q
Sbjct: 1523 --AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1580
Query: 485 ----LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
L I+EE+ + +LE + ++ + L+ L+ + +E + E++ +
Sbjct: 1581 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEAQKRQAQEEAERLR 1637
Query: 541 VLTVALVNQDRENNIEKRSQGLKSEKEA 568
+ R+ +E S+ +K+E EA
Sbjct: 1638 RQVQDESQRKRQAEVELASR-VKAEAEA 1664
Score = 42.4 bits (98), Expect = 0.001
Identities = 74/354 (20%), Positives = 135/354 (38%), Gaps = 30/354 (8%)
Query: 231 KQRMRAREERHRRKLEED-RLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSW 289
KQR+ A R R EE RLR + A E ++ + + +E + +
Sbjct: 1923 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1979
Query: 290 IERGEVNRRSANQFYSMVQ--SANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
GE R ++ + + N +RRL ++A + +EE K + L Q
Sbjct: 1980 ---GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 2036
Query: 348 QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL--RNAQSEQLMGIRREEEMEMSDD 405
+ A + RQK + QR+ ++ EE+ A E+ + E E+E+
Sbjct: 2037 K--ASDSELERQKGLVEDTLRQRRQVE------EEILALKASFEKAAAGKAELELELGRI 2088
Query: 406 ENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLD-----AYRNEVELLKQEKEQLFRT 460
+ T + + AA+ L E + R + + + E E +Q K L
Sbjct: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2148
Query: 461 EENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQ---AKEEQSHTQALLKVLQE 517
E K ++ + L++ + + L + +E K+ + E+ A Q Q L + LQ+
Sbjct: 2149 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2208
Query: 518 QLKGTKEL---VETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
+ +L E + E++ E V Q R E +E++A
Sbjct: 2209 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2262
Score = 41.6 bits (96), Expect = 0.002
Identities = 98/425 (23%), Positives = 177/425 (41%), Gaps = 57/425 (13%)
Query: 233 RMRAREERHRRKL---EEDRLRPPSPPAIMHYSEHEAALLAEKLKDD--SKFS---EAIT 284
R++ E H++ L E RL+ + A S+ E L + +++ + SK EA
Sbjct: 2329 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2388
Query: 285 VLLSWIERGEVNRRSANQFYSMVQSANSHVR-RLMNEKATHEQEMEEAKENFKNALTGIL 343
L ++ R + M Q A R + ++A +++ E + AL +
Sbjct: 2389 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2448
Query: 344 TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL----MGIRR--E 397
+ E++ AV A TR KA + Q++ + +E + ++QL G +R E
Sbjct: 2449 LK-EKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2506
Query: 398 EEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQL 457
E + + + ++ K+RV E + AQA A E D+ R++ A ++ E+L
Sbjct: 2507 AERQRQLEMSAEAERLKLRVAEMS-RAQARA---EEDAQRFRKQA--------EEIGEKL 2554
Query: 458 FRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLK---- 513
RTE Q+ L QT++ +QQ E L +ELE+ KE+ LL+
Sbjct: 2555 HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2611
Query: 514 ----VLQEQLKGTKELVETNGHSHEDS---------------NEINVLTVALVNQDRENN 554
V QEQL + ++ + S +DS ++ VA Q RE
Sbjct: 2612 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2671
Query: 555 IEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLP 614
+++ Q ++ E++ L+ + H + +QQL+ + E E+L
Sbjct: 2672 -QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQ 2729
Query: 615 RMFKQ 619
R+ +Q
Sbjct: 2730 RLREQ 2734
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 53.9 bits (128), Expect = 4e-07
Identities = 76/344 (22%), Positives = 143/344 (41%), Gaps = 43/344 (12%)
Query: 231 KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
+QR A EE RR+ E+R++ S A + A L E + +K EA +
Sbjct: 1949 RQRQLAAEEERRRREAEERVQK-SLAAEEEAARQRKAALEEVERLKAKVEEARRL----- 2002
Query: 291 ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
R + SA Q ++A +RL E+ H +++ ++ + L + +Q+
Sbjct: 2003 -RERAEQESARQLQLAQEAAQ---KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2058
Query: 351 AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ-SEQLMGIRREEEMEMSDDENCD 409
A+ R +A+ + R+ ++ R + +E+L E+ + +
Sbjct: 2059 GEAEAARRAA-----EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2113
Query: 410 SPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQ 469
+K E+A AQA E +LR Q A E+E K+ EQ R + + +Q+
Sbjct: 2114 EKLRKEAEQEAARRAQA-----EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQV--EQE 2165
Query: 470 LQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALL---KVLQEQLKGTKELV 526
L L+ ++ Q + EEL K+E +A ++S + L +V E+L K +
Sbjct: 2166 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2225
Query: 527 ETNGHSHEDSNEINVLTVALVNQDRENN---IEKRSQGLKSEKE 567
E AL+ +D++N +++ ++ +K E
Sbjct: 2226 EAENR-------------ALILRDKDNTQRFLQEEAEKMKQVAE 2256
Score = 51.6 bits (122), Expect = 2e-06
Identities = 76/344 (22%), Positives = 144/344 (41%), Gaps = 20/344 (5%)
Query: 229 ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
E +R R E + L R R A ++ EA L +++D+S+ V L+
Sbjct: 1440 EATERQRGGAEGELQAL---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1496
Query: 289 WIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATH---EQEMEEAKENFKNALTGILTQ 345
R + +A + +Q+ RL E+A + E+E A++ + AL
Sbjct: 1497 --SRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQ-VQVALETAQRS 1551
Query: 346 FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSE-QLMGIRREEEMEMSD 404
E + AS +K Q +++ + + E R AQ + + R E E E+
Sbjct: 1552 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1611
Query: 405 DENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL 464
+ + ++R+ +A Q + E + Q + E + +EQ R E
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRE-- 1666
Query: 465 TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE-QSHTQALLKVLQEQLKGTK 523
+Q+L+ +Q +G QQ L ++EL ++E EQ +++ Q + L ++ +E T+
Sbjct: 1667 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1726
Query: 524 ELVETNGHSHEDSNEINVL--TVALVNQDRENNIEKRSQGLKSE 565
+ E + E+ VL + A ++ + EK Q L++E
Sbjct: 1727 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1770
Score = 43.1 bits (100), Expect = 8e-04
Identities = 69/328 (21%), Positives = 137/328 (41%), Gaps = 50/328 (15%)
Query: 279 FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRR-------LMNEKATHEQEMEEA 331
+ E+ L +W++ RR Q +M + + VR L+ E H +++EE
Sbjct: 1190 YRESADPLGAWLQDA---RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1246
Query: 332 KENFKNALTGI-------LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
+ K + I +T Q+ V + + + K ++ +D+ R H EL
Sbjct: 1247 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL-RTHYSELT 1305
Query: 385 NAQSEQLMGI-----RREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
S+ + I R EEE +++ + + + V E+AL Q L E + + Q
Sbjct: 1306 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV-EAALEKQRQ-LAEAHAQAKAQ 1363
Query: 440 LDAYRNEVELLKQEKEQLFRTEEN-LTKDQQLQFLQQTMQGMQQQL-------------- 484
A R EL ++ +E++ R EE + QQ + +Q+ +Q ++Q
Sbjct: 1364 --AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1421
Query: 485 ----LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
L I+EE+ + +LE + ++ + L+ L+ + +E + E++ +
Sbjct: 1422 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEAQKRQAQEEAERLR 1478
Query: 541 VLTVALVNQDRENNIEKRSQGLKSEKEA 568
+ R+ +E S+ +K+E EA
Sbjct: 1479 RQVQDESQRKRQAEVELASR-VKAEAEA 1505
Score = 42.4 bits (98), Expect = 0.001
Identities = 74/354 (20%), Positives = 135/354 (38%), Gaps = 30/354 (8%)
Query: 231 KQRMRAREERHRRKLEED-RLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSW 289
KQR+ A R R EE RLR + A E ++ + + +E + +
Sbjct: 1764 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1820
Query: 290 IERGEVNRRSANQFYSMVQ--SANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
GE R ++ + + N +RRL ++A + +EE K + L Q
Sbjct: 1821 ---GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1877
Query: 348 QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL--RNAQSEQLMGIRREEEMEMSDD 405
+ A + RQK + QR+ ++ EE+ A E+ + E E+E+
Sbjct: 1878 K--ASDSELERQKGLVEDTLRQRRQVE------EEILALKASFEKAAAGKAELELELGRI 1929
Query: 406 ENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLD-----AYRNEVELLKQEKEQLFRT 460
+ T + + AA+ L E + R + + + E E +Q K L
Sbjct: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1989
Query: 461 EENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQ---AKEEQSHTQALLKVLQE 517
E K ++ + L++ + + L + +E K+ + E+ A Q Q L + LQ+
Sbjct: 1990 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2049
Query: 518 QLKGTKEL---VETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
+ +L E + E++ E V Q R E +E++A
Sbjct: 2050 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2103
Score = 41.6 bits (96), Expect = 0.002
Identities = 98/425 (23%), Positives = 177/425 (41%), Gaps = 57/425 (13%)
Query: 233 RMRAREERHRRKL---EEDRLRPPSPPAIMHYSEHEAALLAEKLKDD--SKFS---EAIT 284
R++ E H++ L E RL+ + A S+ E L + +++ + SK EA
Sbjct: 2170 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2229
Query: 285 VLLSWIERGEVNRRSANQFYSMVQSANSHVR-RLMNEKATHEQEMEEAKENFKNALTGIL 343
L ++ R + M Q A R + ++A +++ E + AL +
Sbjct: 2230 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2289
Query: 344 TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL----MGIRR--E 397
+ E++ AV A TR KA + Q++ + +E + ++QL G +R E
Sbjct: 2290 LK-EKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2347
Query: 398 EEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQL 457
E + + + ++ K+RV E + AQA A E D+ R++ A ++ E+L
Sbjct: 2348 AERQRQLEMSAEAERLKLRVAEMS-RAQARA---EEDAQRFRKQA--------EEIGEKL 2395
Query: 458 FRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLK---- 513
RTE Q+ L QT++ +QQ E L +ELE+ KE+ LL+
Sbjct: 2396 HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2452
Query: 514 ----VLQEQLKGTKELVETNGHSHEDS---------------NEINVLTVALVNQDRENN 554
V QEQL + ++ + S +DS ++ VA Q RE
Sbjct: 2453 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2512
Query: 555 IEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLP 614
+++ Q ++ E++ L+ + H + +QQL+ + E E+L
Sbjct: 2513 -QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQ 2570
Query: 615 RMFKQ 619
R+ +Q
Sbjct: 2571 RLREQ 2575
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 53.9 bits (128), Expect = 4e-07
Identities = 76/344 (22%), Positives = 143/344 (41%), Gaps = 43/344 (12%)
Query: 231 KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
+QR A EE RR+ E+R++ S A + A L E + +K EA +
Sbjct: 1957 RQRQLAAEEERRRREAEERVQK-SLAAEEEAARQRKAALEEVERLKAKVEEARRL----- 2010
Query: 291 ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
R + SA Q ++A +RL E+ H +++ ++ + L + +Q+
Sbjct: 2011 -RERAEQESARQLQLAQEAAQ---KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2066
Query: 351 AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ-SEQLMGIRREEEMEMSDDENCD 409
A+ R +A+ + R+ ++ R + +E+L E+ + +
Sbjct: 2067 GEAEAARRAA-----EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2121
Query: 410 SPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQ 469
+K E+A AQA E +LR Q A E+E K+ EQ R + + +Q+
Sbjct: 2122 EKLRKEAEQEAARRAQA-----EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQV--EQE 2173
Query: 470 LQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALL---KVLQEQLKGTKELV 526
L L+ ++ Q + EEL K+E +A ++S + L +V E+L K +
Sbjct: 2174 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2233
Query: 527 ETNGHSHEDSNEINVLTVALVNQDRENN---IEKRSQGLKSEKE 567
E AL+ +D++N +++ ++ +K E
Sbjct: 2234 EAENR-------------ALILRDKDNTQRFLQEEAEKMKQVAE 2264
Score = 51.6 bits (122), Expect = 2e-06
Identities = 76/344 (22%), Positives = 144/344 (41%), Gaps = 20/344 (5%)
Query: 229 ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
E +R R E + L R R A ++ EA L +++D+S+ V L+
Sbjct: 1448 EATERQRGGAEGELQAL---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1504
Query: 289 WIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATH---EQEMEEAKENFKNALTGILTQ 345
R + +A + +Q+ RL E+A + E+E A++ + AL
Sbjct: 1505 --SRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQ-VQVALETAQRS 1559
Query: 346 FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSE-QLMGIRREEEMEMSD 404
E + AS +K Q +++ + + E R AQ + + R E E E+
Sbjct: 1560 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1619
Query: 405 DENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL 464
+ + ++R+ +A Q + E + Q + E + +EQ R E
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRE-- 1674
Query: 465 TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE-QSHTQALLKVLQEQLKGTK 523
+Q+L+ +Q +G QQ L ++EL ++E EQ +++ Q + L ++ +E T+
Sbjct: 1675 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1734
Query: 524 ELVETNGHSHEDSNEINVL--TVALVNQDRENNIEKRSQGLKSE 565
+ E + E+ VL + A ++ + EK Q L++E
Sbjct: 1735 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1778
Score = 43.1 bits (100), Expect = 8e-04
Identities = 69/328 (21%), Positives = 137/328 (41%), Gaps = 50/328 (15%)
Query: 279 FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRR-------LMNEKATHEQEMEEA 331
+ E+ L +W++ RR Q +M + + VR L+ E H +++EE
Sbjct: 1198 YRESADPLGAWLQDA---RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1254
Query: 332 KENFKNALTGI-------LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
+ K + I +T Q+ V + + + K ++ +D+ R H EL
Sbjct: 1255 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL-RTHYSELT 1313
Query: 385 NAQSEQLMGI-----RREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
S+ + I R EEE +++ + + + V E+AL Q L E + + Q
Sbjct: 1314 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV-EAALEKQRQ-LAEAHAQAKAQ 1371
Query: 440 LDAYRNEVELLKQEKEQLFRTEEN-LTKDQQLQFLQQTMQGMQQQL-------------- 484
A R EL ++ +E++ R EE + QQ + +Q+ +Q ++Q
Sbjct: 1372 --AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1429
Query: 485 ----LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
L I+EE+ + +LE + ++ + L+ L+ + +E + E++ +
Sbjct: 1430 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEAQKRQAQEEAERLR 1486
Query: 541 VLTVALVNQDRENNIEKRSQGLKSEKEA 568
+ R+ +E S+ +K+E EA
Sbjct: 1487 RQVQDESQRKRQAEVELASR-VKAEAEA 1513
Score = 42.4 bits (98), Expect = 0.001
Identities = 74/354 (20%), Positives = 135/354 (38%), Gaps = 30/354 (8%)
Query: 231 KQRMRAREERHRRKLEED-RLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSW 289
KQR+ A R R EE RLR + A E ++ + + +E + +
Sbjct: 1772 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1828
Query: 290 IERGEVNRRSANQFYSMVQ--SANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
GE R ++ + + N +RRL ++A + +EE K + L Q
Sbjct: 1829 ---GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1885
Query: 348 QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL--RNAQSEQLMGIRREEEMEMSDD 405
+ A + RQK + QR+ ++ EE+ A E+ + E E+E+
Sbjct: 1886 K--ASDSELERQKGLVEDTLRQRRQVE------EEILALKASFEKAAAGKAELELELGRI 1937
Query: 406 ENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLD-----AYRNEVELLKQEKEQLFRT 460
+ T + + AA+ L E + R + + + E E +Q K L
Sbjct: 1938 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1997
Query: 461 EENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQ---AKEEQSHTQALLKVLQE 517
E K ++ + L++ + + L + +E K+ + E+ A Q Q L + LQ+
Sbjct: 1998 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2057
Query: 518 QLKGTKEL---VETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
+ +L E + E++ E V Q R E +E++A
Sbjct: 2058 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2111
Score = 41.6 bits (96), Expect = 0.002
Identities = 98/425 (23%), Positives = 177/425 (41%), Gaps = 57/425 (13%)
Query: 233 RMRAREERHRRKL---EEDRLRPPSPPAIMHYSEHEAALLAEKLKDD--SKFS---EAIT 284
R++ E H++ L E RL+ + A S+ E L + +++ + SK EA
Sbjct: 2178 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2237
Query: 285 VLLSWIERGEVNRRSANQFYSMVQSANSHVR-RLMNEKATHEQEMEEAKENFKNALTGIL 343
L ++ R + M Q A R + ++A +++ E + AL +
Sbjct: 2238 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2297
Query: 344 TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL----MGIRR--E 397
+ E++ AV A TR KA + Q++ + +E + ++QL G +R E
Sbjct: 2298 LK-EKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2355
Query: 398 EEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQL 457
E + + + ++ K+RV E + AQA A E D+ R++ A ++ E+L
Sbjct: 2356 AERQRQLEMSAEAERLKLRVAEMS-RAQARA---EEDAQRFRKQA--------EEIGEKL 2403
Query: 458 FRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLK---- 513
RTE Q+ L QT++ +QQ E L +ELE+ KE+ LL+
Sbjct: 2404 HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2460
Query: 514 ----VLQEQLKGTKELVETNGHSHEDS---------------NEINVLTVALVNQDRENN 554
V QEQL + ++ + S +DS ++ VA Q RE
Sbjct: 2461 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2520
Query: 555 IEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLP 614
+++ Q ++ E++ L+ + H + +QQL+ + E E+L
Sbjct: 2521 -QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQ 2578
Query: 615 RMFKQ 619
R+ +Q
Sbjct: 2579 RLREQ 2583
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 53.9 bits (128), Expect = 4e-07
Identities = 76/344 (22%), Positives = 143/344 (41%), Gaps = 43/344 (12%)
Query: 231 KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
+QR A EE RR+ E+R++ S A + A L E + +K EA +
Sbjct: 1998 RQRQLAAEEERRRREAEERVQK-SLAAEEEAARQRKAALEEVERLKAKVEEARRL----- 2051
Query: 291 ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
R + SA Q ++A +RL E+ H +++ ++ + L + +Q+
Sbjct: 2052 -RERAEQESARQLQLAQEAAQ---KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2107
Query: 351 AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ-SEQLMGIRREEEMEMSDDENCD 409
A+ R +A+ + R+ ++ R + +E+L E+ + +
Sbjct: 2108 GEAEAARRAA-----EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2162
Query: 410 SPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQ 469
+K E+A AQA E +LR Q A E+E K+ EQ R + + +Q+
Sbjct: 2163 EKLRKEAEQEAARRAQA-----EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQV--EQE 2214
Query: 470 LQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALL---KVLQEQLKGTKELV 526
L L+ ++ Q + EEL K+E +A ++S + L +V E+L K +
Sbjct: 2215 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2274
Query: 527 ETNGHSHEDSNEINVLTVALVNQDRENN---IEKRSQGLKSEKE 567
E AL+ +D++N +++ ++ +K E
Sbjct: 2275 EAENR-------------ALILRDKDNTQRFLQEEAEKMKQVAE 2305
Score = 51.6 bits (122), Expect = 2e-06
Identities = 76/344 (22%), Positives = 144/344 (41%), Gaps = 20/344 (5%)
Query: 229 ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
E +R R E + L R R A ++ EA L +++D+S+ V L+
Sbjct: 1489 EATERQRGGAEGELQAL---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1545
Query: 289 WIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATH---EQEMEEAKENFKNALTGILTQ 345
R + +A + +Q+ RL E+A + E+E A++ + AL
Sbjct: 1546 --SRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQ-VQVALETAQRS 1600
Query: 346 FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSE-QLMGIRREEEMEMSD 404
E + AS +K Q +++ + + E R AQ + + R E E E+
Sbjct: 1601 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1660
Query: 405 DENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL 464
+ + ++R+ +A Q + E + Q + E + +EQ R E
Sbjct: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRE-- 1715
Query: 465 TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE-QSHTQALLKVLQEQLKGTK 523
+Q+L+ +Q +G QQ L ++EL ++E EQ +++ Q + L ++ +E T+
Sbjct: 1716 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1775
Query: 524 ELVETNGHSHEDSNEINVL--TVALVNQDRENNIEKRSQGLKSE 565
+ E + E+ VL + A ++ + EK Q L++E
Sbjct: 1776 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1819
Score = 43.1 bits (100), Expect = 8e-04
Identities = 69/328 (21%), Positives = 137/328 (41%), Gaps = 50/328 (15%)
Query: 279 FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRR-------LMNEKATHEQEMEEA 331
+ E+ L +W++ RR Q +M + + VR L+ E H +++EE
Sbjct: 1239 YRESADPLGAWLQDA---RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1295
Query: 332 KENFKNALTGI-------LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
+ K + I +T Q+ V + + + K ++ +D+ R H EL
Sbjct: 1296 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL-RTHYSELT 1354
Query: 385 NAQSEQLMGI-----RREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
S+ + I R EEE +++ + + + V E+AL Q L E + + Q
Sbjct: 1355 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV-EAALEKQRQ-LAEAHAQAKAQ 1412
Query: 440 LDAYRNEVELLKQEKEQLFRTEEN-LTKDQQLQFLQQTMQGMQQQL-------------- 484
A R EL ++ +E++ R EE + QQ + +Q+ +Q ++Q
Sbjct: 1413 --AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1470
Query: 485 ----LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
L I+EE+ + +LE + ++ + L+ L+ + +E + E++ +
Sbjct: 1471 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEAQKRQAQEEAERLR 1527
Query: 541 VLTVALVNQDRENNIEKRSQGLKSEKEA 568
+ R+ +E S+ +K+E EA
Sbjct: 1528 RQVQDESQRKRQAEVELASR-VKAEAEA 1554
Score = 42.4 bits (98), Expect = 0.001
Identities = 74/354 (20%), Positives = 135/354 (38%), Gaps = 30/354 (8%)
Query: 231 KQRMRAREERHRRKLEED-RLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSW 289
KQR+ A R R EE RLR + A E ++ + + +E + +
Sbjct: 1813 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1869
Query: 290 IERGEVNRRSANQFYSMVQ--SANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
GE R ++ + + N +RRL ++A + +EE K + L Q
Sbjct: 1870 ---GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1926
Query: 348 QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL--RNAQSEQLMGIRREEEMEMSDD 405
+ A + RQK + QR+ ++ EE+ A E+ + E E+E+
Sbjct: 1927 K--ASDSELERQKGLVEDTLRQRRQVE------EEILALKASFEKAAAGKAELELELGRI 1978
Query: 406 ENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLD-----AYRNEVELLKQEKEQLFRT 460
+ T + + AA+ L E + R + + + E E +Q K L
Sbjct: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2038
Query: 461 EENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQ---AKEEQSHTQALLKVLQE 517
E K ++ + L++ + + L + +E K+ + E+ A Q Q L + LQ+
Sbjct: 2039 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2098
Query: 518 QLKGTKEL---VETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
+ +L E + E++ E V Q R E +E++A
Sbjct: 2099 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2152
Score = 41.6 bits (96), Expect = 0.002
Identities = 98/425 (23%), Positives = 177/425 (41%), Gaps = 57/425 (13%)
Query: 233 RMRAREERHRRKL---EEDRLRPPSPPAIMHYSEHEAALLAEKLKDD--SKFS---EAIT 284
R++ E H++ L E RL+ + A S+ E L + +++ + SK EA
Sbjct: 2219 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2278
Query: 285 VLLSWIERGEVNRRSANQFYSMVQSANSHVR-RLMNEKATHEQEMEEAKENFKNALTGIL 343
L ++ R + M Q A R + ++A +++ E + AL +
Sbjct: 2279 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2338
Query: 344 TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL----MGIRR--E 397
+ E++ AV A TR KA + Q++ + +E + ++QL G +R E
Sbjct: 2339 LK-EKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2396
Query: 398 EEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQL 457
E + + + ++ K+RV E + AQA A E D+ R++ A ++ E+L
Sbjct: 2397 AERQRQLEMSAEAERLKLRVAEMS-RAQARA---EEDAQRFRKQA--------EEIGEKL 2444
Query: 458 FRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLK---- 513
RTE Q+ L QT++ +QQ E L +ELE+ KE+ LL+
Sbjct: 2445 HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2501
Query: 514 ----VLQEQLKGTKELVETNGHSHEDS---------------NEINVLTVALVNQDRENN 554
V QEQL + ++ + S +DS ++ VA Q RE
Sbjct: 2502 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2561
Query: 555 IEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLP 614
+++ Q ++ E++ L+ + H + +QQL+ + E E+L
Sbjct: 2562 -QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQ 2619
Query: 615 RMFKQ 619
R+ +Q
Sbjct: 2620 RLREQ 2624
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,963,546
Number of Sequences: 37866
Number of extensions: 1239967
Number of successful extensions: 12767
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 235
Number of HSP's successfully gapped in prelim test: 832
Number of HSP's that attempted gapping in prelim test: 7682
Number of HSP's gapped (non-prelim): 3611
length of query: 643
length of database: 18,247,518
effective HSP length: 109
effective length of query: 534
effective length of database: 14,120,124
effective search space: 7540146216
effective search space used: 7540146216
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.