Search of human proteins with 188528663

Search of human proteins with 188528663

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|188528663 solute carrier organic anion transporter family,
member 2A1 [Homo sapiens]
         (643 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|188528663 solute carrier organic anion transporter family, me...  1291   0.0  
gi|223634012 solute carrier organic anion transporter family, me...   535   e-152
gi|6005820 solute carrier organic anion transporter family, memb...   535   e-152
gi|222831575 solute carrier organic anion transporter family, me...   412   e-115
gi|222831573 solute carrier organic anion transporter family, me...   412   e-115
gi|223634014 solute carrier organic anion transporter family, me...   405   e-113
gi|8394291 solute carrier organic anion transporter family, memb...   384   e-106
gi|225543118 solute carrier organic anion transporter family, me...   372   e-103
gi|10835099 organic anion transporting polypeptide A [Homo sapiens]   369   e-102
gi|19913403 organic anion transporting polypeptide A [Homo sapiens]   369   e-102
gi|9790233 solute carrier organic anion transporter family, memb...   358   6e-99
gi|225543525 solute carrier organic anion transporter family, me...   353   2e-97
gi|225637473 solute carrier organic anion transporter family, me...   340   3e-93
gi|116812593 liver-specific organic anion transporter 3TM12 [Hom...   339   4e-93
gi|225543116 solute carrier organic anion transporter family, me...   329   5e-90
gi|38679890 solute carrier organic anion transporter family, mem...   318   7e-87
gi|39777594 solute carrier organic anion transporter family memb...   310   3e-84
gi|225543114 solute carrier organic anion transporter family, me...   306   5e-83
gi|225637475 solute carrier organic anion transporter family, me...   292   6e-79
gi|225637477 solute carrier organic anion transporter family, me...   270   3e-72
gi|93277099 solute carrier organic anion transporter family, mem...   214   2e-55
gi|14211875 esophagus cancer-related gene-2 [Homo sapiens]             35   0.16 
gi|5453652 follistatin isoform FST317 precursor [Homo sapiens]         35   0.28 
gi|7242222 follistatin isoform FST344 precursor [Homo sapiens]         35   0.28 
gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]                34   0.36 
gi|185136021 spinster homolog 2 [Homo sapiens]                         33   0.81 
gi|54873613 agrin [Homo sapiens]                                       33   1.1  
gi|11863156 RECK protein precursor [Homo sapiens]                      33   1.1  
gi|145701025 multiple EGF-like-domains 8 [Homo sapiens]                32   1.8  
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]               32   1.8  

>gi|188528663 solute carrier organic anion transporter family,
           member 2A1 [Homo sapiens]
          Length = 643

 Score = 1291 bits (3341), Expect = 0.0
 Identities = 643/643 (100%), Positives = 643/643 (100%)

Query: 1   MGLLPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIE 60
           MGLLPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIE
Sbjct: 1   MGLLPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIE 60

Query: 61  KRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHF 120
           KRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHF
Sbjct: 61  KRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHF 120

Query: 121 LSEPYQYTLASTGNNSRLQAELCQKHWQDLPPSKCHSTTQNPQKETSSMWGLMVVAQLLA 180
           LSEPYQYTLASTGNNSRLQAELCQKHWQDLPPSKCHSTTQNPQKETSSMWGLMVVAQLLA
Sbjct: 121 LSEPYQYTLASTGNNSRLQAELCQKHWQDLPPSKCHSTTQNPQKETSSMWGLMVVAQLLA 180

Query: 181 GIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVN 240
           GIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVN
Sbjct: 181 GIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVN 240

Query: 241 TAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLE 300
           TAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLE
Sbjct: 241 TAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLE 300

Query: 301 EAKSRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTS 360
           EAKSRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTS
Sbjct: 301 EAKSRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTS 360

Query: 361 AAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGC 420
           AAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGC
Sbjct: 361 AAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGC 420

Query: 421 STPTVAEVYPPSTSSSIHPQSPACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMS 480
           STPTVAEVYPPSTSSSIHPQSPACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMS
Sbjct: 421 STPTVAEVYPPSTSSSIHPQSPACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMS 480

Query: 481 SATSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLPAIFLISFVSLIACISHNPLYMMV 540
           SATSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLPAIFLISFVSLIACISHNPLYMMV
Sbjct: 481 SATSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLPAIFLISFVSLIACISHNPLYMMV 540

Query: 541 LRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDND 600
           LRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDND
Sbjct: 541 LRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDND 600

Query: 601 ALRDRYLGLQMGYKALGMLLLCFISWRVKKNKEYNVQKAAGLI 643
           ALRDRYLGLQMGYKALGMLLLCFISWRVKKNKEYNVQKAAGLI
Sbjct: 601 ALRDRYLGLQMGYKALGMLLLCFISWRVKKNKEYNVQKAAGLI 643


>gi|223634012 solute carrier organic anion transporter family,
           member 2B1 isoform 2 [Homo sapiens]
          Length = 687

 Score =  535 bits (1379), Expect = e-152
 Identities = 280/646 (43%), Positives = 403/646 (62%), Gaps = 70/646 (10%)

Query: 26  SVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILI 85
           SVF NIK+FVLC  LLQL QL+ S Y KSS++T+EKRFGLSS +SGL++S NE+ N  LI
Sbjct: 21  SVFHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALI 80

Query: 86  IFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELCQK 145
           +FVSYFGSRVHRPR+IG G + +A    ++TLPHF+SEPY+Y   S  +           
Sbjct: 81  VFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTSPEDMP--------- 131

Query: 146 HWQDLPPSKCHSTTQNPQKETS-------------SMWGLMVVAQLLAGIGTVPIQPFGI 192
             QD   S C  TT  P    S             S+ G+M VAQ L G+G VPIQPFGI
Sbjct: 132 --QDFKASLCLPTTSAPASAPSNGNCSSYTETQHLSVVGIMFVAQTLLGVGGVPIQPFGI 189

Query: 193 SYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPR 252
           SY+DDF+  SNSPLY+ ILFA+++ GP   + LGS+ML+++VD  ++    ++L   DPR
Sbjct: 190 SYIDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPR 249

Query: 253 WIGAWWLGLLISSALLVLTSFPFFFFPRAMP-------IGAKRAPATADEARKLEEAKSR 305
           W+GAWWLG LI++  + L + P+FFFP+ MP          K    T   ARK +++ S+
Sbjct: 250 WVGAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSK 309

Query: 306 GS-------------------LVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLS 346
            S                   ++ FIK FP + L+ L + +F+LVVL+Q   SS+ AG++
Sbjct: 310 QSPGESTKKQDGLVQIAPNLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMA 369

Query: 347 TFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIIT 406
           TFL KFLE+Q+  +A+YAN LIG ++ P+  +G++ GG+L+KR    L   P     +  
Sbjct: 370 TFLPKFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKR----LHLGPVGCGALCL 425

Query: 407 ISMILC----VPLFFMGCSTPTVAEVYPPSTSSSIHP---QSPACRRDCSCPDSIFHPVC 459
           + M+LC    +PLFF+GCS+  +A +   +  +S HP    SP+C   CSCP   F+PVC
Sbjct: 426 LGMLLCLFFSLPLFFIGCSSHQIAGI---THQTSAHPGLELSPSCMEACSCPLDGFNPVC 482

Query: 460 G-DNGIEYLSPCHAGCSN-INMSSATSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLP 517
                +EY++PCHAGCS+ +   +  + Q+ Y NCSCV  G+     GSC   C+H ++P
Sbjct: 483 DPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCSCVVEGN-PVLAGSCDSTCSHLVVP 541

Query: 518 AIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTID 577
            + L+S  S +AC++H P +M++LR V +E+K+ A+G+QF+ +R+LAW+PSP ++G  ID
Sbjct: 542 FLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAID 601

Query: 578 HSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCF 623
            +C+ W +L  GRR  C YY+ND LR+R++GLQ  +K     ++CF
Sbjct: 602 TTCVHW-ALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGS--VICF 644


>gi|6005820 solute carrier organic anion transporter family, member
           2B1 isoform 1 [Homo sapiens]
          Length = 709

 Score =  535 bits (1379), Expect = e-152
 Identities = 280/646 (43%), Positives = 403/646 (62%), Gaps = 70/646 (10%)

Query: 26  SVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILI 85
           SVF NIK+FVLC  LLQL QL+ S Y KSS++T+EKRFGLSS +SGL++S NE+ N  LI
Sbjct: 43  SVFHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALI 102

Query: 86  IFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELCQK 145
           +FVSYFGSRVHRPR+IG G + +A    ++TLPHF+SEPY+Y   S  +           
Sbjct: 103 VFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTSPEDMP--------- 153

Query: 146 HWQDLPPSKCHSTTQNPQKETS-------------SMWGLMVVAQLLAGIGTVPIQPFGI 192
             QD   S C  TT  P    S             S+ G+M VAQ L G+G VPIQPFGI
Sbjct: 154 --QDFKASLCLPTTSAPASAPSNGNCSSYTETQHLSVVGIMFVAQTLLGVGGVPIQPFGI 211

Query: 193 SYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPR 252
           SY+DDF+  SNSPLY+ ILFA+++ GP   + LGS+ML+++VD  ++    ++L   DPR
Sbjct: 212 SYIDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPR 271

Query: 253 WIGAWWLGLLISSALLVLTSFPFFFFPRAMP-------IGAKRAPATADEARKLEEAKSR 305
           W+GAWWLG LI++  + L + P+FFFP+ MP          K    T   ARK +++ S+
Sbjct: 272 WVGAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSK 331

Query: 306 GS-------------------LVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLS 346
            S                   ++ FIK FP + L+ L + +F+LVVL+Q   SS+ AG++
Sbjct: 332 QSPGESTKKQDGLVQIAPNLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMA 391

Query: 347 TFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIIT 406
           TFL KFLE+Q+  +A+YAN LIG ++ P+  +G++ GG+L+KR    L   P     +  
Sbjct: 392 TFLPKFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKR----LHLGPVGCGALCL 447

Query: 407 ISMILC----VPLFFMGCSTPTVAEVYPPSTSSSIHP---QSPACRRDCSCPDSIFHPVC 459
           + M+LC    +PLFF+GCS+  +A +   +  +S HP    SP+C   CSCP   F+PVC
Sbjct: 448 LGMLLCLFFSLPLFFIGCSSHQIAGI---THQTSAHPGLELSPSCMEACSCPLDGFNPVC 504

Query: 460 G-DNGIEYLSPCHAGCSN-INMSSATSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLP 517
                +EY++PCHAGCS+ +   +  + Q+ Y NCSCV  G+     GSC   C+H ++P
Sbjct: 505 DPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCSCVVEGN-PVLAGSCDSTCSHLVVP 563

Query: 518 AIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTID 577
            + L+S  S +AC++H P +M++LR V +E+K+ A+G+QF+ +R+LAW+PSP ++G  ID
Sbjct: 564 FLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAID 623

Query: 578 HSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCF 623
            +C+ W +L  GRR  C YY+ND LR+R++GLQ  +K     ++CF
Sbjct: 624 TTCVHW-ALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGS--VICF 666


>gi|222831575 solute carrier organic anion transporter family,
           member 3A1 isoform 1 [Homo sapiens]
          Length = 710

 Score =  412 bits (1060), Expect = e-115
 Identities = 240/665 (36%), Positives = 358/665 (53%), Gaps = 47/665 (7%)

Query: 8   GASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSS 67
           G  QG +   ++  +   S F NIK+F++ +  L L Q    AY  S LTT+E+RF L S
Sbjct: 16  GELQGDEAQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQS 75

Query: 68  SSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQY 127
           +  G+I+S  EI N  LI+FVSYFG+R HRPRLIG GG+ +A GA +  LP FL+  Y+Y
Sbjct: 76  ADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKY 135

Query: 128 TLAST--GNNSRLQAELCQKHWQDLPPSKCHSTTQNPQKETSSMWGLMVVAQLLAGIGTV 185
                  G   R   ++C  +                +  T+ M+ L++ AQ+L GIG  
Sbjct: 136 EAGEIRWGAEGR---DVCAANGSGGDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGAT 192

Query: 186 PIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVN 245
           P+QP G+SY+DD     +S LYI ILF + VFGPA G++LGS   +I+VD   ++T+ ++
Sbjct: 193 PVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLD 252

Query: 246 LVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLEEAK-- 303
           + P DPRWIGAWW G L+  ALL  +S   F FP+++P  ++  PA   E   L E +  
Sbjct: 253 ITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSE--PAMESEQAMLSEREYE 310

Query: 304 ----------------SRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLST 347
                           S  S    ++  P +   LL N +F  ++LA C   +V+AG + 
Sbjct: 311 RPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAA 370

Query: 348 FLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITI 407
           FL K+LE+Q+  + + AN L+G   +P A LG+  GG+L+K+   S     R+A  +  +
Sbjct: 371 FLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLV 430

Query: 408 SMILCVPLFFMGCSTPTVAEVYPP-----STSSSIHPQSPACRRDCSCPDSIFHPVCGDN 462
           S    V   F+GC T  VA V  P     +  S++ P SP C  +C C    F PVCG +
Sbjct: 431 STACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSP-CNNNCECQTDSFTPVCGAD 489

Query: 463 GIEYLSPCHAGCSNINMSSATSKQLIYLNCSCVT---GGSASAKTGSCPVP-CAHFLLPA 518
           GI YLS C AGC++ N++           C+C+T     +A+   G CP P C    L  
Sbjct: 490 GITYLSACFAGCNSTNLT----------GCACLTTVPAENATVVPGKCPSPGCQEAFLTF 539

Query: 519 IFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDH 578
           + ++   SLI  ++  P  ++++R V+ E KS+A+GV FLL+RLL ++P P ++G  ID 
Sbjct: 540 LCVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDS 599

Query: 579 SCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFISWRVKKN-KEYNVQ 637
           +C+ W++ C G +GAC  YDN   R  Y+ + +  K+   +L       ++KN K Y   
Sbjct: 600 TCLFWSTFC-GEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKN 658

Query: 638 KAAGL 642
              GL
Sbjct: 659 HEGGL 663


>gi|222831573 solute carrier organic anion transporter family,
           member 3A1 isoform 2 [Homo sapiens]
          Length = 692

 Score =  412 bits (1060), Expect = e-115
 Identities = 240/665 (36%), Positives = 358/665 (53%), Gaps = 47/665 (7%)

Query: 8   GASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSS 67
           G  QG +   ++  +   S F NIK+F++ +  L L Q    AY  S LTT+E+RF L S
Sbjct: 16  GELQGDEAQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQS 75

Query: 68  SSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQY 127
           +  G+I+S  EI N  LI+FVSYFG+R HRPRLIG GG+ +A GA +  LP FL+  Y+Y
Sbjct: 76  ADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKY 135

Query: 128 TLAST--GNNSRLQAELCQKHWQDLPPSKCHSTTQNPQKETSSMWGLMVVAQLLAGIGTV 185
                  G   R   ++C  +                +  T+ M+ L++ AQ+L GIG  
Sbjct: 136 EAGEIRWGAEGR---DVCAANGSGGDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGAT 192

Query: 186 PIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVN 245
           P+QP G+SY+DD     +S LYI ILF + VFGPA G++LGS   +I+VD   ++T+ ++
Sbjct: 193 PVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLD 252

Query: 246 LVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLEEAK-- 303
           + P DPRWIGAWW G L+  ALL  +S   F FP+++P  ++  PA   E   L E +  
Sbjct: 253 ITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSE--PAMESEQAMLSEREYE 310

Query: 304 ----------------SRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLST 347
                           S  S    ++  P +   LL N +F  ++LA C   +V+AG + 
Sbjct: 311 RPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAA 370

Query: 348 FLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITI 407
           FL K+LE+Q+  + + AN L+G   +P A LG+  GG+L+K+   S     R+A  +  +
Sbjct: 371 FLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLV 430

Query: 408 SMILCVPLFFMGCSTPTVAEVYPP-----STSSSIHPQSPACRRDCSCPDSIFHPVCGDN 462
           S    V   F+GC T  VA V  P     +  S++ P SP C  +C C    F PVCG +
Sbjct: 431 STACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSP-CNNNCECQTDSFTPVCGAD 489

Query: 463 GIEYLSPCHAGCSNINMSSATSKQLIYLNCSCVT---GGSASAKTGSCPVP-CAHFLLPA 518
           GI YLS C AGC++ N++           C+C+T     +A+   G CP P C    L  
Sbjct: 490 GITYLSACFAGCNSTNLT----------GCACLTTVPAENATVVPGKCPSPGCQEAFLTF 539

Query: 519 IFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDH 578
           + ++   SLI  ++  P  ++++R V+ E KS+A+GV FLL+RLL ++P P ++G  ID 
Sbjct: 540 LCVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDS 599

Query: 579 SCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFISWRVKKN-KEYNVQ 637
           +C+ W++ C G +GAC  YDN   R  Y+ + +  K+   +L       ++KN K Y   
Sbjct: 600 TCLFWSTFC-GEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKN 658

Query: 638 KAAGL 642
              GL
Sbjct: 659 HEGGL 663


>gi|223634014 solute carrier organic anion transporter family,
           member 2B1 isoform 3 [Homo sapiens]
          Length = 565

 Score =  405 bits (1041), Expect = e-113
 Identities = 213/524 (40%), Positives = 318/524 (60%), Gaps = 59/524 (11%)

Query: 148 QDLPPSKCHSTTQNPQKETS-------------SMWGLMVVAQLLAGIGTVPIQPFGISY 194
           QD   S C  TT  P    S             S+ G+M VAQ L G+G VPIQPFGISY
Sbjct: 10  QDFKASLCLPTTSAPASAPSNGNCSSYTETQHLSVVGIMFVAQTLLGVGGVPIQPFGISY 69

Query: 195 VDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWI 254
           +DDF+  SNSPLY+ ILFA+++ GP   + LGS+ML+++VD  ++    ++L   DPRW+
Sbjct: 70  IDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWV 129

Query: 255 GAWWLGLLISSALLVLTSFPFFFFPRAMP-------IGAKRAPATADEARKLEEAKSRGS 307
           GAWWLG LI++  + L + P+FFFP+ MP          K    T   ARK +++ S+ S
Sbjct: 130 GAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQS 189

Query: 308 -------------------LVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTF 348
                              ++ FIK FP + L+ L + +F+LVVL+Q   SS+ AG++TF
Sbjct: 190 PGESTKKQDGLVQIAPNLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATF 249

Query: 349 LNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITIS 408
           L KFLE+Q+  +A+YAN LIG ++ P+  +G++ GG+L+KR    L   P     +  + 
Sbjct: 250 LPKFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKR----LHLGPVGCGALCLLG 305

Query: 409 MILC----VPLFFMGCSTPTVAEVYPPSTSSSIHP---QSPACRRDCSCPDSIFHPVCG- 460
           M+LC    +PLFF+GCS+  +A +   +  +S HP    SP+C   CSCP   F+PVC  
Sbjct: 306 MLLCLFFSLPLFFIGCSSHQIAGI---THQTSAHPGLELSPSCMEACSCPLDGFNPVCDP 362

Query: 461 DNGIEYLSPCHAGCSN-INMSSATSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLPAI 519
              +EY++PCHAGCS+ +   +  + Q+ Y NCSCV  G+     GSC   C+H ++P +
Sbjct: 363 STRVEYITPCHAGCSSWVVQDALDNSQVFYTNCSCVVEGN-PVLAGSCDSTCSHLVVPFL 421

Query: 520 FLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHS 579
            L+S  S +AC++H P +M++LR V +E+K+ A+G+QF+ +R+LAW+PSP ++G  ID +
Sbjct: 422 LLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTT 481

Query: 580 CIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCF 623
           C+ W +L  GRR  C YY+ND LR+R++GLQ  +K     ++CF
Sbjct: 482 CVHW-ALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGS--VICF 522


>gi|8394291 solute carrier organic anion transporter family, member
           1C1 isoform 2 [Homo sapiens]
          Length = 712

 Score =  384 bits (986), Expect = e-106
 Identities = 211/635 (33%), Positives = 339/635 (53%), Gaps = 39/635 (6%)

Query: 29  GNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFV 88
           G +KVF+     +   + L   Y KS++T IE+RF + SS  G+I    EI N ++I FV
Sbjct: 40  GELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFV 99

Query: 89  SYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELCQ-KHW 147
           SYFG+++HRP++IG G + +  G  ++ +P F  E Y+Y   S  +NS L    C  +  
Sbjct: 100 SYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYERYSPSSNSTLSISPCLLESS 159

Query: 148 QDLPPSKCHSTTQNPQKE-----TSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPS 202
             LP S    +      E     +SSMW  + +  LL GIG  PIQP GI+Y+DDF+   
Sbjct: 160 SQLPVSVMEKSKSKISNECEVDTSSSMWIYVFLGNLLRGIGETPIQPLGIAYLDDFASED 219

Query: 203 NSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLL 262
           N+  YI  +  +++ GP FG+LLGS+  +++VD G VN   + + P DP+W+GAWWLG L
Sbjct: 220 NAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYL 279

Query: 263 ISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLEEAK--------------SRGSL 308
           I+  + +L + PF++ P+++P    R+ +  D     E++K                  +
Sbjct: 280 IAGIISLLAAVPFWYLPKSLP----RSQSREDSNSSSEKSKFIIDDHTDYQTPQGENAKI 335

Query: 309 VDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLI 368
           ++  + F      L  N ++ L +       + + G+ T+  K++E+QYG S++ ANF+I
Sbjct: 336 MEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVI 395

Query: 369 GAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEV 428
           G +N+PA ALG+  GGI+MK+F  S+    ++         +L + LF +GC    VA +
Sbjct: 396 GLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGL 455

Query: 429 ---YPPSTSSSIHPQS--PACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSAT 483
              Y  +   S H ++    C   C C ++ + P+CG+NGI Y+S C AGC   N S   
Sbjct: 456 TVSYQGTKPVSYHERALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRS--- 512

Query: 484 SKQLIYLNCSCV-----TGGSASAKTGSCPVP--CAHFLLPAIFLISFVSLIACISHNPL 536
            K +I+ NC+CV       G++S   G C     C    L  + +    S    +   P 
Sbjct: 513 GKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPG 572

Query: 537 YMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAY 596
           Y+++LR +  + KSFA+G+  L +R+LA +P+P  +G+ ID SC++W     G RG+C  
Sbjct: 573 YILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRL 632

Query: 597 YDNDALRDRYLGLQMGYKALGMLLLCFISWRVKKN 631
           YD++  R  YLGL +    + +LL   + + +KKN
Sbjct: 633 YDSNVFRHIYLGLTVILGTVSILLSIAVLFILKKN 667


>gi|225543118 solute carrier organic anion transporter family,
           member 1C1 isoform 1 [Homo sapiens]
          Length = 730

 Score =  372 bits (955), Expect = e-103
 Identities = 202/607 (33%), Positives = 324/607 (53%), Gaps = 39/607 (6%)

Query: 29  GNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFV 88
           G +KVF+     +   + L   Y KS++T IE+RF + SS  G+I    EI N ++I FV
Sbjct: 40  GELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFV 99

Query: 89  SYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELCQ-KHW 147
           SYFG+++HRP++IG G + +  G  ++ +P F  E Y+Y   S  +NS L    C  +  
Sbjct: 100 SYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYERYSPSSNSTLSISPCLLESS 159

Query: 148 QDLPPSKCHSTTQNPQKE-----TSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPS 202
             LP S    +      E     +SSMW  + +  LL GIG  PIQP GI+Y+DDF+   
Sbjct: 160 SQLPVSVMEKSKSKISNECEVDTSSSMWIYVFLGNLLRGIGETPIQPLGIAYLDDFASED 219

Query: 203 NSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLL 262
           N+  YI  +  +++ GP FG+LLGS+  +++VD G VN   + + P DP+W+GAWWLG L
Sbjct: 220 NAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYL 279

Query: 263 ISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLEEAK--------------SRGSL 308
           I+  + +L + PF++ P+++P    R+ +  D     E++K                  +
Sbjct: 280 IAGIISLLAAVPFWYLPKSLP----RSQSREDSNSSSEKSKFIIDDHTDYQTPQGENAKI 335

Query: 309 VDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLI 368
           ++  + F      L  N ++ L +       + + G+ T+  K++E+QYG S++ ANF+I
Sbjct: 336 MEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVI 395

Query: 369 GAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEV 428
           G +N+PA ALG+  GGI+MK+F  S+    ++         +L + LF +GC    VA +
Sbjct: 396 GLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGL 455

Query: 429 ---YPPSTSSSIHPQS--PACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSAT 483
              Y  +   S H ++    C   C C ++ + P+CG+NGI Y+S C AGC   N S   
Sbjct: 456 TVSYQGTKPVSYHERALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRS--- 512

Query: 484 SKQLIYLNCSCV-----TGGSASAKTGSCPVP--CAHFLLPAIFLISFVSLIACISHNPL 536
            K +I+ NC+CV       G++S   G C     C    L  + +    S    +   P 
Sbjct: 513 GKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPG 572

Query: 537 YMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAY 596
           Y+++LR +  + KSFA+G+  L +R+LA +P+P  +G+ ID SC++W     G RG+C  
Sbjct: 573 YILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRL 632

Query: 597 YDNDALR 603
           YD++  R
Sbjct: 633 YDSNVFR 639


>gi|10835099 organic anion transporting polypeptide A [Homo sapiens]
          Length = 670

 Score =  369 bits (947), Expect = e-102
 Identities = 215/602 (35%), Positives = 324/602 (53%), Gaps = 39/602 (6%)

Query: 31  IKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSY 90
           +K+F+L      + + L  +Y  S LT IE++F + +S  G I+   EI N +LIIFVSY
Sbjct: 19  LKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSY 78

Query: 91  FGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQY--TLASTGNNSRLQAELCQKHWQ 148
           FG+++HRP +IGIG + +  G F+ +LPHFL   Y+Y  T++ +GN S       +   Q
Sbjct: 79  FGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQ 138

Query: 149 DLPPSKCHSTTQNPQKET----SSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNS 204
            L P      TQ+P + T    S MW  ++V  ++ G+G  PI P GISY++DF++  NS
Sbjct: 139 ILRP------TQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKFENS 192

Query: 205 PLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLIS 264
           PLYI ++   ++ GP  G LL S    ++VD G VNT  + + P D RW+GAWW G LI 
Sbjct: 193 PLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLIC 252

Query: 265 SALLVLTSFPFFFFPRAMPIGAKRAPA----TADEARKLEEAKSR--GSLVDFIKRFPCI 318
           + + VLT+ PFFF P  +P       A      +E ++ EE K    G   DF+      
Sbjct: 253 AGVNVLTAIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGITKDFLP----F 308

Query: 319 FLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAAL 378
              L  N +++L +L      +    + +F+ K+LE+QYG S++ A FL+G  NLP   +
Sbjct: 309 MKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICI 368

Query: 379 GMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEVYPPSTSSSIH 438
           G + GG++MK+F  +++    I   +  +  +L    F M C   +V  +   +TS    
Sbjct: 369 GYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGI---NTSYEGI 425

Query: 439 PQS--------PACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYL 490
           PQ           C  DC+CP  I+ PVCG+NG+ YLS C AGC     S  T   +++ 
Sbjct: 426 PQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCET---SIGTGINMVFQ 482

Query: 491 NCSCV-TGGSASAKTGSCP--VPCAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQE 547
           NCSC+ T G++SA  G C     C+  L   + L +  S I  ++  P YM++LR +  E
Sbjct: 483 NCSCIQTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSE 542

Query: 548 EKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYL 607
           EKS  +G+     R+ A +P+P  +G  +D +C+ W +L  G  GAC  YD+   R  YL
Sbjct: 543 EKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYL 602

Query: 608 GL 609
           GL
Sbjct: 603 GL 604


>gi|19913403 organic anion transporting polypeptide A [Homo sapiens]
          Length = 670

 Score =  369 bits (947), Expect = e-102
 Identities = 215/602 (35%), Positives = 324/602 (53%), Gaps = 39/602 (6%)

Query: 31  IKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSY 90
           +K+F+L      + + L  +Y  S LT IE++F + +S  G I+   EI N +LIIFVSY
Sbjct: 19  LKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSY 78

Query: 91  FGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQY--TLASTGNNSRLQAELCQKHWQ 148
           FG+++HRP +IGIG + +  G F+ +LPHFL   Y+Y  T++ +GN S       +   Q
Sbjct: 79  FGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQ 138

Query: 149 DLPPSKCHSTTQNPQKET----SSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNS 204
            L P      TQ+P + T    S MW  ++V  ++ G+G  PI P GISY++DF++  NS
Sbjct: 139 ILRP------TQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKFENS 192

Query: 205 PLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLIS 264
           PLYI ++   ++ GP  G LL S    ++VD G VNT  + + P D RW+GAWW G LI 
Sbjct: 193 PLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLIC 252

Query: 265 SALLVLTSFPFFFFPRAMPIGAKRAPA----TADEARKLEEAKSR--GSLVDFIKRFPCI 318
           + + VLT+ PFFF P  +P       A      +E ++ EE K    G   DF+      
Sbjct: 253 AGVNVLTAIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGITKDFLP----F 308

Query: 319 FLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAAL 378
              L  N +++L +L      +    + +F+ K+LE+QYG S++ A FL+G  NLP   +
Sbjct: 309 MKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICI 368

Query: 379 GMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEVYPPSTSSSIH 438
           G + GG++MK+F  +++    I   +  +  +L    F M C   +V  +   +TS    
Sbjct: 369 GYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGI---NTSYEGI 425

Query: 439 PQS--------PACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYL 490
           PQ           C  DC+CP  I+ PVCG+NG+ YLS C AGC     S  T   +++ 
Sbjct: 426 PQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCET---SIGTGINMVFQ 482

Query: 491 NCSCV-TGGSASAKTGSCP--VPCAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQE 547
           NCSC+ T G++SA  G C     C+  L   + L +  S I  ++  P YM++LR +  E
Sbjct: 483 NCSCIQTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSE 542

Query: 548 EKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYL 607
           EKS  +G+     R+ A +P+P  +G  +D +C+ W +L  G  GAC  YD+   R  YL
Sbjct: 543 EKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYL 602

Query: 608 GL 609
           GL
Sbjct: 603 GL 604


>gi|9790233 solute carrier organic anion transporter family, member
           1B3 [Homo sapiens]
          Length = 702

 Score =  358 bits (920), Expect = 6e-99
 Identities = 222/665 (33%), Positives = 348/665 (52%), Gaps = 40/665 (6%)

Query: 4   LPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRF 63
           L K   S  S+   +R  RC        K+F+       + + L     K S+T IE+RF
Sbjct: 7   LNKTAESASSEKKKTR--RC-----NGFKMFLAALSFSYIAKALGGIIMKISITQIERRF 59

Query: 64  GLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSE 123
            +SSS +GLI    EI N ++I+FVSYFGS++HRP+LIGIG L +  G+ + +LPHF   
Sbjct: 60  DISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFFMG 119

Query: 124 PYQY---TLASTGNNSRLQAELCQ-KHWQDLPPSKCHSTTQNPQKETSS-MWGLMVVAQL 178
            Y+Y   T  +   NS      C          +      ++  KE+ S MW  + +  +
Sbjct: 120 YYRYSKETHINPSENSTSSLSTCLINQTLSFNGTSPEIVEKDCVKESGSHMWIYVFMGNM 179

Query: 179 LAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGR 238
           L GIG  PI P GISY+DDF++  +S LY+  L AI + GP  G+ LGS+  +++VD G 
Sbjct: 180 LRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGY 239

Query: 239 VNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAP-------- 290
           V+ + + + P D RW+GAWWLG L+S    +++S PFFF P+      K           
Sbjct: 240 VDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKNPNKPQKERKISLSLHVL 299

Query: 291 ATADEARKLEEAKSRG-SLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFL 349
            T D+  +     ++G ++   +  F      +L N L+V+ +L      S   G  T++
Sbjct: 300 KTNDDRNQTANLTNQGKNVTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYV 359

Query: 350 NKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISM 409
            K++E+QYG SA++ANFL+G + +P  A GM  GG ++K+F  SL  I + +     IS 
Sbjct: 360 FKYMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISF 419

Query: 410 ILCVPLFFMGCSTPTVAEV---YPPSTSSSIHPQSPA--CRRDCSCPDSIFHPVCGDNGI 464
           +  +  F + C + +VA +   Y  + S + H   P   C  +C+C +S + PVCG+NGI
Sbjct: 420 LFQLLYFPLICESKSVAGLTLTYDGNNSVASHVDVPLSYCNSECNCDESQWEPVCGNNGI 479

Query: 465 EYLSPCHAGCSNINMSSATSKQLIYLNCSC--VTG---GSASAKTGSCP--VPCAH--FL 515
            YLSPC AGC +   SS   K  ++ NCSC  VTG    + SA  G CP    C    F+
Sbjct: 480 TYLSPCLAGCKS---SSGIKKHTVFYNCSCVEVTGLQNRNYSAHLGECPRDNTCTRKFFI 536

Query: 516 LPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLT 575
             AI +I+  SL +        ++ +++V  E K+ A+G Q +++R L  + +P  +G  
Sbjct: 537 YVAIQVIN--SLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGAL 594

Query: 576 IDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFISWRVKKNKEYN 635
           ID +C++W++   G +GAC  Y++      YLGL +  +   ++L     + +KK  +  
Sbjct: 595 IDKTCMKWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPALVLYIVFIFAMKKKFQGK 654

Query: 636 VQKAA 640
             KA+
Sbjct: 655 DTKAS 659


>gi|225543525 solute carrier organic anion transporter family,
           member 1B1 [Homo sapiens]
          Length = 691

 Score =  353 bits (907), Expect = 2e-97
 Identities = 210/629 (33%), Positives = 335/629 (53%), Gaps = 35/629 (5%)

Query: 31  IKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSY 90
           +K+F+    L  + + L +   KSS+  IE+RF +SSS  G I    EI N ++I+FVSY
Sbjct: 27  LKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSY 86

Query: 91  FGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYT----LASTGNNSRLQAELCQKH 146
           FGS++HRP+LIGIG   +  G  +  LPHF    Y+Y+    + S+ N++   +      
Sbjct: 87  FGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNINSSENSTSTLSTCLINQ 146

Query: 147 WQDLPPSKCHSTTQNPQKETSS-MWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSP 205
              L  +      +   KE+ S MW  + +  +L GIG  PI P G+SY+DDF++  +S 
Sbjct: 147 ILSLNRASPEIVGKGCLKESGSYMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSS 206

Query: 206 LYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISS 265
           LY+ IL AI++ GP  G+ LGS+  +++VD G V+ + + + P D RW+GAWWL  L+S 
Sbjct: 207 LYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSG 266

Query: 266 ALLVLTSFPFFFFPRAMPIGAKRAPA--------TADEARKLEEAKSRG-SLVDFIKRFP 316
              +++S PFFF P+      K   A        T DE  +     ++G ++   +  F 
Sbjct: 267 LFSIISSIPFFFLPQTPNKPQKERKASLSLHVLETNDEKDQTANLTNQGKNITKNVTGFF 326

Query: 317 CIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAA 376
             F  +L N L+V+ VL      S   G  T++ K++E+QYG  ++ AN L+G + +P  
Sbjct: 327 QSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIF 386

Query: 377 ALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEV---YPPST 433
           A GM  GG ++K+F  +   I + +     +S+   +  FF+ C   +VA +   Y  + 
Sbjct: 387 ASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAGLTMTYDGNN 446

Query: 434 SSSIHPQSPA--CRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLN 491
             + H   P   C  DC+C +S + PVCG+NGI Y+SPC AGC +   SS   K +++ N
Sbjct: 447 PVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKS---SSGNKKPIVFYN 503

Query: 492 CSC--VTG---GSASAKTGSCPVPCA-----HFLLPAIFLISFVSLIACISHNPLYMMVL 541
           CSC  VTG    + SA  G CP   A     +F +    L  F S +   SH    M+++
Sbjct: 504 CSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSH---VMLIV 560

Query: 542 RVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDA 601
           ++V  E KS A+G   +++R L  + +P  +G  ID +CI+W++   G RG+C  Y++ +
Sbjct: 561 KIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTS 620

Query: 602 LRDRYLGLQMGYKALGMLLLCFISWRVKK 630
               YLGL    +   ++L   + + +KK
Sbjct: 621 FSRVYLGLSSMLRVSSLVLYIILIYAMKK 649


>gi|225637473 solute carrier organic anion transporter family,
           member 5A1 isoform 1 [Homo sapiens]
          Length = 848

 Score =  340 bits (871), Expect = 3e-93
 Identities = 213/669 (31%), Positives = 341/669 (50%), Gaps = 69/669 (10%)

Query: 22  RCARSVFGNIKVFVLCQGLLQLCQ-LLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEIS 80
           RC   V  + + F++C   L   Q L+ S Y  S +TTIE+R+ L SS SGL+ S  +I 
Sbjct: 118 RCLYVVLTDSRCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIG 177

Query: 81  NAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQA 140
           N ++++FVSYFG R  RP  + +GGL +A GA +  LPHF+S PYQ       N S    
Sbjct: 178 NLVVVVFVSYFGGRGRRPLWLAVGGLLIAFGAALFALPHFISPPYQ---IQELNASAPND 234

Query: 141 ELCQ--KHWQDLPPSKCHSTTQNPQKETSSMW---GLMVVAQLLAGIGTVPIQPFGISYV 195
            LCQ       L P  C   +       ++ W    L + AQ+L G+G+ PI   G +Y+
Sbjct: 235 GLCQGGNSTATLEPPACPKDSGG-----NNHWVYVALFICAQILIGMGSTPIYTLGPTYL 289

Query: 196 DDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIG 255
           DD  +  NS LY++I++ +   GPA GYLLG +++  +VD        V+L   DPR+IG
Sbjct: 290 DDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVD----PRNPVHLDQNDPRFIG 345

Query: 256 AWWLGLLISSALLVLTSFPFFFFPRAMPIGAKR-------APATADE------ARKLEEA 302
            WW G L+ +  + L  FP F FP+ +P   K+         A +D+      +   E+A
Sbjct: 346 NWWSGFLLCAIAMFLVIFPMFTFPKKLPPRHKKKKKKKFSVDAVSDDDVLKEKSNNSEQA 405

Query: 303 KSRGSLVDF---IKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGT 359
             + S + F   ++  P   +R+L N  F+ V L+    S+++    TF+ KF+E Q+G 
Sbjct: 406 DKKVSSMGFGKDVRDLPRAAVRILSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGI 465

Query: 360 SAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMG 419
            A+ A+   G + +P+A +G++ GG ++K+     +   ++A     +S++    LF +G
Sbjct: 466 PASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVG 525

Query: 420 CSTPTVAEVYPPSTS--SSIHPQ---SPACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGC 474
           C +  +  +  P T+  S   P    + +C  +C C    + PVCG +GI Y +PC AGC
Sbjct: 526 CESINLGGINIPYTTGPSLTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGC 585

Query: 475 SNINMSSATSKQLIYLNCSCV---------TGGSAS----------------AKTGSCPV 509
             +N  + ++    Y  C+CV         T G  S                A +G C  
Sbjct: 586 --VNSGNLSTGIRNYTECTCVQSRQVITPPTVGQRSQLRVVIVKTYLNENGYAVSGKCKR 643

Query: 510 PCAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSP 569
            C + L+P +  +  V+ I   +     ++ LR V  EE+ FA+G+QF+L+R LA++P+P
Sbjct: 644 TC-NTLIPFLVFLFIVTFITACAQPSAIIVTLRSVEDEERPFALGMQFVLLRTLAYIPTP 702

Query: 570 ALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFISWRVK 629
             +G  ID +C+ W   C G +G+C  Y+  + R  Y GL  G K +G + + F++W   
Sbjct: 703 IYFGAVIDTTCMLWQQEC-GVQGSCWEYNVTSFRFVYFGLAAGLKFVGFIFI-FLAWYSI 760

Query: 630 KNKEYNVQK 638
           K KE  +Q+
Sbjct: 761 KYKEDGLQR 769


>gi|116812593 liver-specific organic anion transporter 3TM12 [Homo
           sapiens]
          Length = 640

 Score =  339 bits (870), Expect = 4e-93
 Identities = 206/605 (34%), Positives = 321/605 (53%), Gaps = 31/605 (5%)

Query: 53  KSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGA 112
           K S T IE+RF +SSS  GLI    EI N  +I+FVSYFGS++HRP+LIGIG   +  G+
Sbjct: 2   KISTTQIERRFEISSSLVGLIDGSFEIGNLFVIVFVSYFGSKLHRPKLIGIGCFLMGTGS 61

Query: 113 FILTLPHFLSEPYQY---TLASTGNNSRLQAELCQ-KHWQDLPPSKCHSTTQNPQKETSS 168
            ++ LPHF    Y+Y   T      NS      C       L  +      +   KE+ S
Sbjct: 62  ILMALPHFFMGYYRYSKETNIDPSENSTSNLPNCLINQMLSLNRTPSEIIERGCVKESGS 121

Query: 169 -MWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGS 227
            MW  + +  +L GIG  PI P GISY+DDF++  +S LY+  +  + + G  F ++LGS
Sbjct: 122 HMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGTVNVMGMTGLVFAFMLGS 181

Query: 228 VMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAK 287
           +  +++VD G V+ + + + P D RW+GAWWLG L+S  + +++S PFFF P       K
Sbjct: 182 LFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGIVSIISSIPFFFLPLNPNKPQK 241

Query: 288 RAPA--------TADEARKLEEAKSRGS-LVDFIKRFPCIFLRLLMNSLFVL-VVLAQCT 337
                       T D+  ++    +R   +   +  F      +L N L+V+ V+     
Sbjct: 242 ERKVSLFLHVLKTNDKRNQIANLTNRRKYITKNVTGFFQSLKSILTNPLYVIFVIFTLLH 301

Query: 338 FSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAI 397
            SS IA L T++ K +E+QYG SA+  NFL+G + LPA A+GM  GG ++K+F  SL  +
Sbjct: 302 MSSYIASL-TYIIKMVEQQYGWSASKTNFLLGVLALPAVAIGMFSGGYIIKKFKLSLVGL 360

Query: 398 PRIATTIITISMILCVPLFFMGCSTPTVAEV---YPPSTSSSIHPQSPA--CRRDCSCPD 452
            ++A    T+ ++  V  FF+ C + +VA +   Y  ++    H   P   C  +C+C +
Sbjct: 361 AKLAFCSATVHLLSQVLYFFLICESKSVAGLTLTYDGNSPVRSHVDVPLSYCNSECNCDE 420

Query: 453 SIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCV-----TGGSASAKTGSC 507
           S + PVCG+NGI YLSPC AGC +   SS   + +++ NCSCV        + SA  G C
Sbjct: 421 SQWEPVCGNNGITYLSPCLAGCKS---SSGNKEPIVFYNCSCVEVIGLQNKNYSAHLGEC 477

Query: 508 PVPCAHFLLPAIFLISFV--SLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAW 565
           P   A      ++ +  V  + +  +      ++V+R+V  E K+ AIG   ++MR L  
Sbjct: 478 PRDDACTRKSYVYFVIQVLDAFLCAVGLTSYSVLVIRIVQPELKALAIGFHSMIMRSLGG 537

Query: 566 LPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFIS 625
           +  P  +G  ID +C++W++   G RGAC  Y++  L   + GL++      ++LL    
Sbjct: 538 ILVPIYFGALIDTTCMKWSTNSCGARGACRIYNSTYLGRAFFGLKVALIFPVLVLLTVFI 597

Query: 626 WRVKK 630
           + V+K
Sbjct: 598 FVVRK 602


>gi|225543116 solute carrier organic anion transporter family,
           member 1C1 isoform 3 [Homo sapiens]
          Length = 663

 Score =  329 bits (843), Expect = 5e-90
 Identities = 191/629 (30%), Positives = 313/629 (49%), Gaps = 76/629 (12%)

Query: 29  GNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFV 88
           G +KVF+     +   + L   Y KS++T IE+RF + SS  G+I    EI N ++I FV
Sbjct: 40  GELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFV 99

Query: 89  SYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELCQKHWQ 148
           SYFG+++HRP++IG G + +  G  ++ +P F  E Y+Y   S  +NS L    C     
Sbjct: 100 SYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYERYSPSSNSTLSISPC----- 154

Query: 149 DLPPSKCHSTTQNPQKETSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYI 208
                                        LL     +P+            E S S +  
Sbjct: 155 -----------------------------LLESSSQLPVSVM---------EKSKSKISN 176

Query: 209 SILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALL 268
             +  +++ GP FG+LLGS+  +++VD G VN   + + P DP+W+GAWWLG LI+  + 
Sbjct: 177 GCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIIS 236

Query: 269 VLTSFPFFFFPRAMPIGAKRAPATADEARKLEEAK--------------SRGSLVDFIKR 314
           +L + PF++ P+++P    R+ +  D     E++K                  +++  + 
Sbjct: 237 LLAAVPFWYLPKSLP----RSQSREDSNSSSEKSKFIIDDHTDYQTPQGENAKIMEMARD 292

Query: 315 FPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLP 374
           F      L  N ++ L +       + + G+ T+  K++E+QYG S++ ANF+IG +N+P
Sbjct: 293 FLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIP 352

Query: 375 AAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEV---YPP 431
           A ALG+  GGI+MK+F  S+    ++         +L + LF +GC    VA +   Y  
Sbjct: 353 AVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQG 412

Query: 432 STSSSIHPQS--PACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIY 489
           +   S H ++    C   C C ++ + P+CG+NGI Y+S C AGC   N S    K +I+
Sbjct: 413 TKPVSYHERALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRS---GKNIIF 469

Query: 490 LNCSCV-----TGGSASAKTGSCPVP--CAHFLLPAIFLISFVSLIACISHNPLYMMVLR 542
            NC+CV       G++S   G C     C    L  + +    S    +   P Y+++LR
Sbjct: 470 YNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLR 529

Query: 543 VVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDAL 602
            +  + KSFA+G+  L +R+LA +P+P  +G+ ID SC++W     G RG+C  YD++  
Sbjct: 530 CIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVF 589

Query: 603 RDRYLGLQMGYKALGMLLLCFISWRVKKN 631
           R  YLGL +    + +LL   + + +KKN
Sbjct: 590 RHIYLGLTVILGTVSILLSIAVLFILKKN 618


>gi|38679890 solute carrier organic anion transporter family, member
           4C1 [Homo sapiens]
          Length = 724

 Score =  318 bits (816), Expect = 7e-87
 Identities = 198/610 (32%), Positives = 310/610 (50%), Gaps = 61/610 (10%)

Query: 34  FVLCQGLLQLCQ-LLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFG 92
           F+L   LL + Q ++ +     S++T+EKR+ + SS +GLISS  +IS  +L +FVS+FG
Sbjct: 107 FLLHYCLLAVTQGIVVNGLVNISISTVEKRYEMKSSLTGLISSSYDISFCLLSLFVSFFG 166

Query: 93  SRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQY------TLASTGNNSRLQAELCQKH 146
            R H+PR +      +  GA + +LP F S  Y+       T  +T N++          
Sbjct: 167 ERGHKPRWLAFAAFMIGLGALVFSLPQFFSGEYKLGSLFEDTCVTTRNST---------- 216

Query: 147 WQDLPPSKCHSTTQNPQKETSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPL 206
                   C S+T +     S+   + ++ QLL G G  P+   G +++DD      S L
Sbjct: 217 -------SCTSSTSS----LSNYLYVFILGQLLLGAGGTPLYTLGTAFLDDSVPTHKSSL 265

Query: 207 YISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSA 266
           YI   +A+S+ GPA GY+LG  +L I++D     +  V     DPRW+GAWW+G L+S  
Sbjct: 266 YIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTDVT--EDDPRWLGAWWIGFLLSWI 323

Query: 267 LLVLTSFPFFFFPRAMPIGAKRAPATAD-EARKLEEAKSRGSLVDF-----IKRFPCIFL 320
                  PF  FP       K  P TA+ +A K  +A    S  D      IK FP    
Sbjct: 324 FAWSLIIPFSCFP-------KHLPGTAEIQAGKTSQAHQSNSNADVKFGKSIKDFPAALK 376

Query: 321 RLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGM 380
            L+ N++F+ +VL+  + + +  G +TFL KF+E Q+G ++++A  L GAV +P AALG 
Sbjct: 377 NLMKNAVFMCLVLSTSSEALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQ 436

Query: 381 LFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEVYPP-STSSSIHP 439
           + GG L+ +F  + +   + A     +++ L     +  C     A V    + +  +  
Sbjct: 437 ILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEPFAGVSESYNGTGELGN 496

Query: 440 QSPACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCVTGGS 499
               C  +C+C  S ++PVCGD G++Y SPC AGCSN     A  K  +Y NCSC+   +
Sbjct: 497 LIAPCNANCNCSRSYYYPVCGD-GVQYFSPCFAGCSN---PVAHRKPKVYYNCSCIERKT 552

Query: 500 A----------SAKTGSCPVPCAHFLLPAIFLISFVSLI-ACISHNPLYMMVLRVVNQEE 548
                       AK G C   CA   LP    I F+ +I   ++  P+ + +LR VN  +
Sbjct: 553 EITSTAETFGFEAKAGKCETHCAK--LPIFLCIFFIVIIFTFMAGTPITVSILRCVNHRQ 610

Query: 549 KSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLG 608
           +S A+G+QF+++RLL  +P P ++G TID +CI W+    G +GAC  YDN  +    + 
Sbjct: 611 RSLALGIQFMVLRLLGTIPGPIIFGFTIDSTCILWDINDCGIKGACWIYDNIKMAHMLVA 670

Query: 609 LQMGYKALGM 618
           + +  K + M
Sbjct: 671 ISVTCKVITM 680


>gi|39777594 solute carrier organic anion transporter family member
           4A1 [Homo sapiens]
          Length = 722

 Score =  310 bits (794), Expect = 3e-84
 Identities = 192/610 (31%), Positives = 309/610 (50%), Gaps = 45/610 (7%)

Query: 33  VFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFG 92
           +F LC     L  +  + +  + +T++E+R+ L S  SGLI+S  +I+  + + FVSYFG
Sbjct: 106 LFFLCAAAF-LQGMTVNGFINTVITSLERRYDLHSYQSGLIASSYDIAACLCLTFVSYFG 164

Query: 93  SRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELCQKHWQDLPP 152
              H+PR +G G L +  G+ +  LPHF +  Y+  L +           C  +    P 
Sbjct: 165 GSGHKPRWLGWGVLLMGTGSLVFALPHFTAGRYEVELDA-------GVRTCPAN----PG 213

Query: 153 SKCHSTTQNPQKETSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILF 212
           + C  +T       S    + ++ Q L G+G  P+   G++Y+D+  + S SP+YI+I +
Sbjct: 214 AVCADSTSG----LSRYQLVFMLGQFLHGVGATPLYTLGVTYLDENVKSSCSPVYIAIFY 269

Query: 213 AISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTS 272
             ++ GPA GYL+G  +L I+ + GR       L    P W+GAWW+G L S A    T+
Sbjct: 270 TAAILGPAAGYLIGGALLNIYTEMGR----RTELTTESPLWVGAWWVGFLGSGAAAFFTA 325

Query: 273 FPFFFFPRAMPIGAKRAPATADEARKLEE-AKSRGSLVDF---IKRFPCIFLRLLMNSLF 328
            P   +PR +P   + A   A E  +L++ ++   S  DF   I+  P     LL N  F
Sbjct: 326 VPILGYPRQLPGSQRYAVMRAAEMHQLKDSSRGEASNPDFGKTIRDLPLSIWLLLKNPTF 385

Query: 329 VLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMK 388
           +L+ LA  T +++I G+STF  KFLE Q+  SA+ A  L G + +PA   G   GG  + 
Sbjct: 386 ILLCLAGATEATLITGMSTFSPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFFVN 445

Query: 389 RFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEVYPPSTSSSIHPQ-----SPA 443
           +      A+ +      T+  +L + +F + C +  +A V   S   S+ P+     +  
Sbjct: 446 KLRLRGSAVIKFC-LFCTVVSLLGILVFSLHCPSVPMAGV-TASYGGSLLPEGHLNLTAP 503

Query: 444 CRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCV----TGGS 499
           C   CSC    + PVCG +G+ Y S CHAGC     ++    Q +Y +CSC+    + G 
Sbjct: 504 CNAACSCQPEHYSPVCGSDGLMYFSLCHAGCPAATETNVDG-QKVYRDCSCIPQNLSSGF 562

Query: 500 ASAKTGSCPVPCAH--FLLPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQF 557
             A  G C   C     LL  IF++ F + ++ I   P     LR V   ++SFA+G+Q+
Sbjct: 563 GHATAGKCTSTCQRKPLLLVFIFVVIFFTFLSSI---PALTATLRCVRDPQRSFALGIQW 619

Query: 558 LLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALG 617
           +++R+L  +P P  +G  ID +C+ W   C G++G+C  Y N A+    L + + YK LG
Sbjct: 620 IVVRILGGIPGPIAFGWVIDKACLLWQDQC-GQQGSCLVYQNSAMSRYILIMGLLYKVLG 678

Query: 618 ML---LLCFI 624
           +L   + CF+
Sbjct: 679 VLFFAIACFL 688


>gi|225543114 solute carrier organic anion transporter family,
           member 1C1 isoform 4 [Homo sapiens]
          Length = 612

 Score =  306 bits (783), Expect = 5e-83
 Identities = 169/528 (32%), Positives = 274/528 (51%), Gaps = 39/528 (7%)

Query: 108 LAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELCQ-KHWQDLPPSKCHSTTQNPQKE- 165
           +  G  ++ +P F  E Y+Y   S  +NS L    C  +    LP S    +      E 
Sbjct: 1   MGVGTLLIAMPQFFMEQYKYERYSPSSNSTLSISPCLLESSSQLPVSVMEKSKSKISNEC 60

Query: 166 ----TSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAF 221
               +SSMW  + +  LL GIG  PIQP GI+Y+DDF+   N+  YI  +  +++ GP F
Sbjct: 61  EVDTSSSMWIYVFLGNLLRGIGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIF 120

Query: 222 GYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRA 281
           G+LLGS+  +++VD G VN   + + P DP+W+GAWWLG LI+  + +L + PF++ P++
Sbjct: 121 GFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKS 180

Query: 282 MPIGAKRAPATADEARKLEEAK--------------SRGSLVDFIKRFPCIFLRLLMNSL 327
           +P    R+ +  D     E++K                  +++  + F      L  N +
Sbjct: 181 LP----RSQSREDSNSSSEKSKFIIDDHTDYQTPQGENAKIMEMARDFLPSLKNLFGNPV 236

Query: 328 FVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILM 387
           + L +       + + G+ T+  K++E+QYG S++ ANF+IG +N+PA ALG+  GGI+M
Sbjct: 237 YFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVM 296

Query: 388 KRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEV---YPPSTSSSIHPQS--P 442
           K+F  S+    ++         +L + LF +GC    VA +   Y  +   S H ++   
Sbjct: 297 KKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQGTKPVSYHERALFS 356

Query: 443 ACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCV-----TG 497
            C   C C ++ + P+CG+NGI Y+S C AGC   N S    K +I+ NC+CV       
Sbjct: 357 DCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRS---GKNIIFYNCTCVGIAASKS 413

Query: 498 GSASAKTGSCPVP--CAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGV 555
           G++S   G C     C    L  + +    S    +   P Y+++LR +  + KSFA+G+
Sbjct: 414 GNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGI 473

Query: 556 QFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALR 603
             L +R+LA +P+P  +G+ ID SC++W     G RG+C  YD++  R
Sbjct: 474 YTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVFR 521


>gi|225637475 solute carrier organic anion transporter family,
           member 5A1 isoform 3 [Homo sapiens]
          Length = 793

 Score =  292 bits (748), Expect = 6e-79
 Identities = 198/653 (30%), Positives = 314/653 (48%), Gaps = 92/653 (14%)

Query: 22  RCARSVFGNIKVFVLCQGLLQLCQ-LLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEIS 80
           RC   V  + + F++C   L   Q L+ S Y  S +TTIE+R+ L SS SGL+ S  +I 
Sbjct: 118 RCLYVVLTDSRCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIG 177

Query: 81  NAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQA 140
           N ++++FVSYFG R  RP  + +GGL +A GA +  LPHF+S PYQ       N S    
Sbjct: 178 NLVVVVFVSYFGGRGRRPLWLAVGGLLIAFGAALFALPHFISPPYQ---IQELNASAPND 234

Query: 141 ELCQ--KHWQDLPPSKCHSTTQNPQKETSSMW---GLMVVAQLLAGIGTVPIQPFGISYV 195
            LCQ       L P  C   +       ++ W    L + AQ+L G+G+ PI   G +Y+
Sbjct: 235 GLCQGGNSTATLEPPACPKDSGG-----NNHWVYVALFICAQILIGMGSTPIYTLGPTYL 289

Query: 196 DDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIG 255
           DD  +  NS LY++I++ +   GPA GYLLG +++  +VD        V+L   DPR+IG
Sbjct: 290 DDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVD----PRNPVHLDQNDPRFIG 345

Query: 256 AWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLEEAKSRGSLVDFIKRF 315
            WW G L+ +  + L  FP F FP+ +P   K+              K +   VD +   
Sbjct: 346 NWWSGFLLCAIAMFLVIFPMFTFPKKLPPRHKK-------------KKKKKFSVDAVSDD 392

Query: 316 PCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPA 375
                           VL + + +S  A               +S  +   + G + +P+
Sbjct: 393 D---------------VLKEKSNNSEQADKKV-----------SSMGFGKDVRGVIIVPS 426

Query: 376 AALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEVYPPSTS- 434
           A +G++ GG ++K+     +   ++A     +S++    LF +GC +  +  +  P T+ 
Sbjct: 427 AGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGCESINLGGINIPYTTG 486

Query: 435 -SSIHPQ---SPACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYL 490
            S   P    + +C  +C C    + PVCG +GI Y +PC AGC  +N  + ++    Y 
Sbjct: 487 PSLTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGC--VNSGNLSTGIRNYT 544

Query: 491 NCSCV---------TGGSAS----------------AKTGSCPVPCAHFLLPAIFLISFV 525
            C+CV         T G  S                A +G C   C + L+P +  +  V
Sbjct: 545 ECTCVQSRQVITPPTVGQRSQLRVVIVKTYLNENGYAVSGKCKRTC-NTLIPFLVFLFIV 603

Query: 526 SLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNS 585
           + I   +     ++ LR V  EE+ FA+G+QF+L+R LA++P+P  +G  ID +C+ W  
Sbjct: 604 TFITACAQPSAIIVTLRSVEDEERPFALGMQFVLLRTLAYIPTPIYFGAVIDTTCMLWQQ 663

Query: 586 LCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFISWRVKKNKEYNVQK 638
            C G +G+C  Y+  + R  Y GL  G K +G + + F++W   K KE  +Q+
Sbjct: 664 EC-GVQGSCWEYNVTSFRFVYFGLAAGLKFVGFIFI-FLAWYSIKYKEDGLQR 714


>gi|225637477 solute carrier organic anion transporter family,
           member 5A1 isoform 2 [Homo sapiens]
          Length = 687

 Score =  270 bits (690), Expect = 3e-72
 Identities = 163/501 (32%), Positives = 260/501 (51%), Gaps = 41/501 (8%)

Query: 22  RCARSVFGNIKVFVLCQGLLQLCQ-LLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEIS 80
           RC   V  + + F++C   L   Q L+ S Y  S +TTIE+R+ L SS SGL+ S  +I 
Sbjct: 118 RCLYVVLTDSRCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIG 177

Query: 81  NAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQA 140
           N ++++FVSYFG R  RP  + +GGL +A GA +  LPHF+S PYQ       N S    
Sbjct: 178 NLVVVVFVSYFGGRGRRPLWLAVGGLLIAFGAALFALPHFISPPYQ---IQELNASAPND 234

Query: 141 ELCQ--KHWQDLPPSKCHSTTQNPQKETSSMW---GLMVVAQLLAGIGTVPIQPFGISYV 195
            LCQ       L P  C   +       ++ W    L + AQ+L G+G+ PI   G +Y+
Sbjct: 235 GLCQGGNSTATLEPPACPKDSGG-----NNHWVYVALFICAQILIGMGSTPIYTLGPTYL 289

Query: 196 DDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIG 255
           DD  +  NS LY++I++ +   GPA GYLLG +++  +VD        V+L   DPR+IG
Sbjct: 290 DDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVD----PRNPVHLDQNDPRFIG 345

Query: 256 AWWLGLLISSALLVLTSFPFFFFPRAMPIGAKR-------APATADE------ARKLEEA 302
            WW G L+ +  + L  FP F FP+ +P   K+         A +D+      +   E+A
Sbjct: 346 NWWSGFLLCAIAMFLVIFPMFTFPKKLPPRHKKKKKKKFSVDAVSDDDVLKEKSNNSEQA 405

Query: 303 KSRGSLVDF---IKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGT 359
             + S + F   ++  P   +R+L N  F+ V L+    S+++    TF+ KF+E Q+G 
Sbjct: 406 DKKVSSMGFGKDVRDLPRAAVRILSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGI 465

Query: 360 SAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMG 419
            A+ A+   G + +P+A +G++ GG ++K+     +   ++A     +S++    LF +G
Sbjct: 466 PASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVG 525

Query: 420 CSTPTVAEVYPPSTS--SSIHPQ---SPACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGC 474
           C +  +  +  P T+  S   P    + +C  +C C    + PVCG +GI Y +PC AGC
Sbjct: 526 CESINLGGINIPYTTGPSLTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGC 585

Query: 475 SNINMSSATSKQLIYLNCSCV 495
             +N  + ++    Y  C+CV
Sbjct: 586 --VNSGNLSTGIRNYTECTCV 604


>gi|93277099 solute carrier organic anion transporter family, member
           6A1 [Homo sapiens]
          Length = 719

 Score =  214 bits (546), Expect = 2e-55
 Identities = 158/611 (25%), Positives = 281/611 (45%), Gaps = 56/611 (9%)

Query: 30  NIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVS 89
           NI+ F++   +L +CQ +       S+   +K + L +     +    +IS+ ++ IF++
Sbjct: 104 NIRCFMIFYCILLICQGVVFGLIDVSIGDFQKEYQLKTIEKLALEKSYDISSGLVAIFIA 163

Query: 90  YFGSR------VHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELC 143
           ++G R      V    LIG+G L  A        P    E  Q  +           ++C
Sbjct: 164 FYGDRKKVIWFVASSFLIGLGSLLCA-------FPSINEENKQSKVGIE--------DIC 208

Query: 144 QKHWQDLPPSKCHSTTQNPQKETSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSN 203
           +   +    S C S+  + Q +  S +   ++ Q + GI  +P+   GI+++D+     +
Sbjct: 209 E---EIKVVSGCQSSGISFQSKYLSFF---ILGQTVQGIAGMPLYILGITFIDENVATHS 262

Query: 204 SPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLI 263
           + +Y+ I    S+ G A GY+LG+ ++++  +        VN   G P W+  WW+  L 
Sbjct: 263 AGIYLGIAECTSMIGYALGYVLGAPLVKVPENTTSATNTTVN--NGSPEWLWTWWINFLF 320

Query: 264 SSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLEEAKSRGSLVDFIKRFPCIFLRLL 323
           ++ +   T  P   FP  MP G+ R  A   +     +++ +   +    +  C  L +L
Sbjct: 321 AAVVAWCTLIPLSCFPNNMP-GSTRIKARKRKQLHFFDSRLKDLKLGTNIKDLCAALWIL 379

Query: 324 M-NSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLF 382
           M N + + + L++ T   VI G S FL  +LE Q+  +   A  L G V +P  ALG L 
Sbjct: 380 MKNPVLICLALSKATEYLVIIGASEFLPIYLENQFILTPTVATTLAGLVLIPGGALGQLL 439

Query: 383 GGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEVYPP-STSSSIHPQS 441
           GG+++     S +A+ R       IS+IL V + F+ C+    A +      +  +   +
Sbjct: 440 GGVIVSTLEMSCKALMRFIMVTSVISLILLVFIIFVRCNPVQFAGINEDYDGTGKLGNLT 499

Query: 442 PACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCV------ 495
             C   C C  SI+  +CG + IEY SPC AGC+    S A +++ +Y NCSC+      
Sbjct: 500 APCNEKCRCSSSIYSSICGRDDIEYFSPCFAGCT---YSKAQNQKKMYYNCSCIKEGLIT 556

Query: 496 ---TGGSASAKTGSCPVPCAHFLLPAIFLISFVSLI-ACISHNPLYMMVLRVVNQEEKSF 551
               G    A+ G C   C  + LP      F +LI +  S  P+ + + RVV  + +S 
Sbjct: 557 ADAEGDFIDARPGKCDAKC--YKLPLFIAFIFSTLIFSGFSGVPIVLAMTRVVPDKLRSL 614

Query: 552 AIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQM 611
           A+GV ++++R+   +P P+++ ++ + SCI  +    G  G C  Y+           +M
Sbjct: 615 ALGVSYVILRIFGTIPGPSIFKMSGETSCILRDVNKCGHTGRCWIYNK---------TKM 665

Query: 612 GYKALGMLLLC 622
            +  +G+  LC
Sbjct: 666 AFLLVGICFLC 676


>gi|14211875 esophagus cancer-related gene-2 [Homo sapiens]
          Length = 85

 Score = 35.4 bits (80), Expect = 0.16
 Identities = 19/63 (30%), Positives = 30/63 (47%), Gaps = 5/63 (7%)

Query: 409 MILCVPLFFMGCSTPTVAEVYPPSTSSSIHPQSPACRRDCSCPDSIFHPVCGDNGIEYLS 468
           ++LC  ++F  CS+   A + P     SI+ + P     C      + PVCG + I Y +
Sbjct: 8   LLLCTVVYF--CSSSEAASLSPKKVDCSIYKKYPVVAIPCPIT---YLPVCGSDYITYGN 62

Query: 469 PCH 471
            CH
Sbjct: 63  ECH 65


>gi|5453652 follistatin isoform FST317 precursor [Homo sapiens]
          Length = 317

 Score = 34.7 bits (78), Expect = 0.28
 Identities = 18/60 (30%), Positives = 29/60 (48%), Gaps = 5/60 (8%)

Query: 417 FMGCSTPTVAEVYPPSTSSSIHPQSP-----ACRRDCSCPDSIFHPVCGDNGIEYLSPCH 471
           + G    T  +V+ P +S+ +  Q+       C R C  P S    +CG++G+ Y S CH
Sbjct: 160 YQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACH 219


>gi|7242222 follistatin isoform FST344 precursor [Homo sapiens]
          Length = 344

 Score = 34.7 bits (78), Expect = 0.28
 Identities = 18/60 (30%), Positives = 29/60 (48%), Gaps = 5/60 (8%)

Query: 417 FMGCSTPTVAEVYPPSTSSSIHPQSP-----ACRRDCSCPDSIFHPVCGDNGIEYLSPCH 471
           + G    T  +V+ P +S+ +  Q+       C R C  P S    +CG++G+ Y S CH
Sbjct: 160 YQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACH 219


>gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]
          Length = 1140

 Score = 34.3 bits (77), Expect = 0.36
 Identities = 20/61 (32%), Positives = 22/61 (36%), Gaps = 16/61 (26%)

Query: 447 DCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCVTGGSASAKTGS 506
           +CSCP      VCG        PC  G    N S           C C  GG+  A TG 
Sbjct: 252 ECSCPSGWMGTVCGQ-------PCPEGRFGKNCSQ---------ECQCHNGGTCDAATGQ 295

Query: 507 C 507
           C
Sbjct: 296 C 296



 Score = 30.4 bits (67), Expect = 5.3
 Identities = 29/101 (28%), Positives = 38/101 (37%), Gaps = 21/101 (20%)

Query: 412 CVPLFF-MGCSTPTVAEVYPPSTSSSIHPQSPACRRDCSCPDSIFHPVCGDNGIEYLSPC 470
           C P F  + CSTP     Y  + SS        C+ D  C      PV G         C
Sbjct: 430 CAPGFKGIDCSTPCPLGTYGINCSSRC-----GCKNDAVCS-----PVDGS------CTC 473

Query: 471 HAGCSNINMS----SATSKQLIYLNCSCVTGGSASAKTGSC 507
            AG   ++ S    S T      L C C+ GG+ +   G+C
Sbjct: 474 KAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGTC 514


>gi|185136021 spinster homolog 2 [Homo sapiens]
          Length = 549

 Score = 33.1 bits (74), Expect = 0.81
 Identities = 35/181 (19%), Positives = 62/181 (34%), Gaps = 47/181 (25%)

Query: 56  LTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFIL 115
           L  I++ FG+    +GL+ S+   S  +      Y G R +R  ++  G  F +A  F  
Sbjct: 126 LLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185

Query: 116 TLPHFLSEPYQYTLASTGNNSRLQAELCQKHWQDLPPSKCHSTTQNPQKETSSMWGLMVV 175
           +   F+ + Y                                            W L+V+
Sbjct: 186 S---FIPQQY-------------------------------------------FW-LLVL 198

Query: 176 AQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVD 235
           ++ L GIG         + + D    +   L +S+ +     G   GY+ GS + Q   D
Sbjct: 199 SRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGD 258

Query: 236 Y 236
           +
Sbjct: 259 W 259


>gi|54873613 agrin [Homo sapiens]
          Length = 2045

 Score = 32.7 bits (73), Expect = 1.1
 Identities = 28/98 (28%), Positives = 38/98 (38%), Gaps = 14/98 (14%)

Query: 417 FMGCSTPTVAEVYPPSTSSSIHPQS---PACRRDCSCPDSIFHPVCGDNGIEYLSPCHAG 473
           F G   P    +  PS S  ++P++       R  SCP +   PVCGD+G+ Y + C  G
Sbjct: 313 FDGPCDPCQGALPDPSRSCRVNPRTRRPEMLLRPESCP-ARQAPVCGDDGVTYENDCVMG 371

Query: 474 CSNINMSSATSKQLIYLNCSCVTGGSASAKTGSCPVPC 511
            S         K         V  G    +   CP PC
Sbjct: 372 RSGAARGLLLQK---------VRSGQCQGR-DQCPEPC 399



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 21/70 (30%), Positives = 31/70 (44%), Gaps = 6/70 (8%)

Query: 444 CRRDCSCPDSIFHPVCGDNGIEYLSPC--HAGCSNINMSSATSKQLIYLNC-SCVTGGSA 500
           C + CS   S++ PVCG +G+ Y S C   A    +      +++     C  C  G   
Sbjct: 490 CLQACS---SLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQCRFGALC 546

Query: 501 SAKTGSCPVP 510
            A+TG C  P
Sbjct: 547 EAETGRCVCP 556



 Score = 29.6 bits (65), Expect = 9.0
 Identities = 19/57 (33%), Positives = 26/57 (45%), Gaps = 10/57 (17%)

Query: 457 PVCGDNGIEYLSPC---HAGC---SNINMSSATSKQLIYLNCSCVTGGSASAKTGSC 507
           PVCG +G+ Y S C    A C   + I  + A   +       C +GGS S + G C
Sbjct: 630 PVCGSDGVTYGSACELREAACLQQTQIEEARAGPCE----QAECGSGGSGSGEDGDC 682


>gi|11863156 RECK protein precursor [Homo sapiens]
          Length = 971

 Score = 32.7 bits (73), Expect = 1.1
 Identities = 15/27 (55%), Positives = 16/27 (59%), Gaps = 1/27 (3%)

Query: 448 CSCPDSIFHPVCGDNGIEYLSPCHAGC 474
           C+C D  F PVCG NG  Y S C A C
Sbjct: 633 CNCADQ-FVPVCGQNGRTYPSACIARC 658


>gi|145701025 multiple EGF-like-domains 8 [Homo sapiens]
          Length = 2778

 Score = 32.0 bits (71), Expect = 1.8
 Identities = 17/57 (29%), Positives = 24/57 (42%), Gaps = 5/57 (8%)

Query: 414  PLFFMGCSTPTVAEVYPPSTSSSIHPQSPACRRDCSCPDSIFHPVCGDNGIEYLSPC 470
            P F   C     +++ PP+ +    P +P C RDC C    FH  C   G  +   C
Sbjct: 1064 PDFTCVCDLGWTSDLPPPTPAPG--PPAPRCSRDCGCS---FHSHCRKRGPGFCDEC 1115


>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
          Length = 1044

 Score = 32.0 bits (71), Expect = 1.8
 Identities = 27/100 (27%), Positives = 39/100 (39%), Gaps = 19/100 (19%)

Query: 412 CVPLFFMG--CSTPTVAEVYPPSTSSSIHPQSPACRRDCSCPDSIFHPVC--GDNGIEYL 467
           C P  FMG  C+    A  Y P+ SS       +C    +C        C  G  G++  
Sbjct: 424 CAP-GFMGEVCAVSCAAGTYGPNCSSIC-----SCNNGGTCSPVDGSCTCKEGWQGLDCT 477

Query: 468 SPCHAGCSNINMSSATSKQLIYLNCSCVTGGSASAKTGSC 507
            PC +G   +N + +         C+C  G + S   GSC
Sbjct: 478 LPCPSGTWGLNCNES---------CTCANGAACSPIDGSC 508



 Score = 30.0 bits (66), Expect = 6.9
 Identities = 24/67 (35%), Positives = 27/67 (40%), Gaps = 15/67 (22%)

Query: 447 DCS----CPDSIFHPVC--GDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCVTGGSA 500
           DCS    C     H  C  G  GI   S C  G    N S         ++CSC  GGS 
Sbjct: 537 DCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCS---------VSCSCENGGSC 587

Query: 501 SAKTGSC 507
           S + GSC
Sbjct: 588 SPEDGSC 594


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.139    0.432 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,424,326
Number of Sequences: 37866
Number of extensions: 1021918
Number of successful extensions: 3570
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 3369
Number of HSP's gapped (non-prelim): 102
length of query: 643
length of database: 18,247,518
effective HSP length: 109
effective length of query: 534
effective length of database: 14,120,124
effective search space: 7540146216
effective search space used: 7540146216
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.