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Search of human proteins with 103471999
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|103471999 serine/threonine kinase 3 [Homo sapiens]
(491 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 989 0.0
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 760 0.0
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 313 2e-85
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 310 2e-84
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 310 2e-84
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 306 4e-83
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 266 3e-71
gi|145275208 myosin IIIA [Homo sapiens] 265 5e-71
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 260 2e-69
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 260 2e-69
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 260 2e-69
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 260 2e-69
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 260 2e-69
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 260 2e-69
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 260 2e-69
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 260 2e-69
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 259 3e-69
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 259 3e-69
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 259 3e-69
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 259 3e-69
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 256 3e-68
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 256 4e-68
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 256 4e-68
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 256 4e-68
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 256 4e-68
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 250 2e-66
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 250 2e-66
gi|134288915 myosin IIIB isoform 1 [Homo sapiens] 248 9e-66
gi|134288892 myosin IIIB isoform 2 [Homo sapiens] 248 9e-66
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 248 1e-65
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 989 bits (2556), Expect = 0.0
Identities = 491/491 (100%), Positives = 491/491 (100%)
Query: 1 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV 60
MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV
Sbjct: 1 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV 60
Query: 61 ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIE 120
ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIE
Sbjct: 61 ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIE 120
Query: 121 DEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT 180
DEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT
Sbjct: 121 DEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT 180
Query: 181 VIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPT 240
VIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPT
Sbjct: 181 VIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPT 240
Query: 241 FRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAK 300
FRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAK
Sbjct: 241 FRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAK 300
Query: 301 RHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLES 360
RHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLES
Sbjct: 301 RHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLES 360
Query: 361 DLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPM 420
DLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPM
Sbjct: 361 DLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPM 420
Query: 421 SKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDA 480
SKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDA
Sbjct: 421 SKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDA 480
Query: 481 MDAKKRRQQNF 491
MDAKKRRQQNF
Sbjct: 481 MDAKKRRQQNF 491
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 760 bits (1962), Expect = 0.0
Identities = 380/486 (78%), Positives = 435/486 (89%), Gaps = 9/486 (1%)
Query: 7 PKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE 66
P+ +LKKL EDSLTKQPEEVFDVLEKLGEGSYGSV+KAIHKE+GQ+VAIKQVPVESDLQE
Sbjct: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
Query: 67 IIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATI 126
IIKEISIMQQCDSP+VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTL EDEIATI
Sbjct: 70 IIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATI 129
Query: 127 LKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPF 186
L+STLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPF
Sbjct: 130 LQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPF 189
Query: 187 WMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEL 246
WMAPEVIQEIGYNCVADIWSLGIT+IEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEL
Sbjct: 190 WMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEL 249
Query: 247 WSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQ 306
WSD+FTDFVK+CLVK+PEQRATATQLLQHPF+++AK VSILRDLI EAM++K KR E QQ
Sbjct: 250 WSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQ 309
Query: 307 REL-EEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTM 365
RE+ +++EENS+EDE+DS TMV+ + +GT+R STM++GA TMIEH+ T L S LGTM
Sbjct: 310 REVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDT-LPSQLGTM 368
Query: 366 VINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVF 425
VIN+EDEEEE GTMKR + Q +PSF++YF++ K K ++ + P P+ +
Sbjct: 369 VINAEDEEEE-GTMKRRDETMQPAKPSFLEYFEQ---KEKENQINSFGKSVPGPLKNS-- 422
Query: 426 PDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKK 485
+WK+PQDGD++FLK+ ++E+LQ RL ALDPMME+EIEE+RQ+Y +KRQPILDA++AKK
Sbjct: 423 -SDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKK 481
Query: 486 RRQQNF 491
RRQQNF
Sbjct: 482 RRQQNF 487
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 313 bits (803), Expect = 2e-85
Identities = 160/306 (52%), Positives = 213/306 (69%), Gaps = 8/306 (2%)
Query: 23 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES---DLQEIIKEISIMQQCDS 79
PEE+F LE++G+GS+G VFK I + QVVAIK + +E ++++I +EI+++ QCDS
Sbjct: 20 PEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 79
Query: 80 PYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 139
YV KYYGSY K + LWI+MEY G GS D+ LR E +IAT+LK LKGL+YLH
Sbjct: 80 SYVTKYYGSYLKGSKLWIIMEYLGGGSALDL--LRAGPFDEFQIATMLKEILKGLDYLHS 137
Query: 140 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 199
+KIHRDIKA N+LL+ +G KLADFGVAGQLTDT KRNT +GTPFWMAPEVIQ+ Y+
Sbjct: 138 EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYD 197
Query: 200 CVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCL 259
ADIWSLGIT+IE+A+G+PP +D+HPMR +F+IP N PPT ++ F +F+ CL
Sbjct: 198 SKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGD--FTKSFKEFIDACL 255
Query: 260 VKNPEQRATATQLLQHPFI-KNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDE 318
K+P R TA +LL+H FI KN+K S L +LI KA+ H + + + E + S
Sbjct: 256 NKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTS 315
Query: 319 DELDSH 324
E ++H
Sbjct: 316 RENNTH 321
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 310 bits (794), Expect = 2e-84
Identities = 160/306 (52%), Positives = 213/306 (69%), Gaps = 13/306 (4%)
Query: 18 SLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES---DLQEIIKEISIM 74
+L PEE+F LEK+G+GS+G VFK I + +VVAIK + +E ++++I +EI+++
Sbjct: 15 NLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVL 74
Query: 75 QQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGL 134
QCDSPYV KYYGSY K+T LWI+MEY G GS D+ L L E +IATIL+ LKGL
Sbjct: 75 SQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDL--LEPGPLDETQIATILREILKGL 132
Query: 135 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 194
+YLH +KIHRDIKA N+LL+ G KLADFGVAGQLTDT KRNT +GTPFWMAPEVI+
Sbjct: 133 DYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK 192
Query: 195 EIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDF 254
+ Y+ ADIWSLGIT+IE+A G+PP++++HPM+ +F+IP N PPT +S +F
Sbjct: 193 QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN--YSKPLKEF 250
Query: 255 VKKCLVKNPEQRATATQLLQHPFI-KNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEE 313
V+ CL K P R TA +LL+H FI +NAK S L +LI + KR + +Q +
Sbjct: 251 VEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELID-----RYKRWKAEQSHDDSSS 305
Query: 314 ENSDED 319
E+SD +
Sbjct: 306 EDSDAE 311
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 310 bits (794), Expect = 2e-84
Identities = 160/306 (52%), Positives = 213/306 (69%), Gaps = 13/306 (4%)
Query: 18 SLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES---DLQEIIKEISIM 74
+L PEE+F LEK+G+GS+G VFK I + +VVAIK + +E ++++I +EI+++
Sbjct: 27 NLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVL 86
Query: 75 QQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGL 134
QCDSPYV KYYGSY K+T LWI+MEY G GS D+ L L E +IATIL+ LKGL
Sbjct: 87 SQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDL--LEPGPLDETQIATILREILKGL 144
Query: 135 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 194
+YLH +KIHRDIKA N+LL+ G KLADFGVAGQLTDT KRNT +GTPFWMAPEVI+
Sbjct: 145 DYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK 204
Query: 195 EIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDF 254
+ Y+ ADIWSLGIT+IE+A G+PP++++HPM+ +F+IP N PPT +S +F
Sbjct: 205 QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN--YSKPLKEF 262
Query: 255 VKKCLVKNPEQRATATQLLQHPFI-KNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEE 313
V+ CL K P R TA +LL+H FI +NAK S L +LI + KR + +Q +
Sbjct: 263 VEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELID-----RYKRWKAEQSHDDSSS 317
Query: 314 ENSDED 319
E+SD +
Sbjct: 318 EDSDAE 323
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 306 bits (783), Expect = 4e-83
Identities = 154/301 (51%), Positives = 210/301 (69%), Gaps = 8/301 (2%)
Query: 23 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES---DLQEIIKEISIMQQCDS 79
PEE+F L+++G+GS+G V+K I + +VVAIK + +E ++++I +EI+++ QCDS
Sbjct: 16 PEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 75
Query: 80 PYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 139
PY+ +Y+GSY K+T LWI+MEY G GS D+ L+ L E IATIL+ LKGL+YLH
Sbjct: 76 PYITRYFGSYLKSTKLWIIMEYLGGGSALDL--LKPGPLEETYIATILREILKGLDYLHS 133
Query: 140 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 199
RKIHRDIKA N+LL+ +G KLADFGVAGQLTDT KRNT +GTPFWMAPEVI++ Y+
Sbjct: 134 ERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYD 193
Query: 200 CVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCL 259
ADIWSLGIT+IE+A+G+PP +D+HPMR +F+IP N PPT S F +FV+ CL
Sbjct: 194 FKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH--SKPFKEFVEACL 251
Query: 260 VKNPEQRATATQLLQHPFI-KNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDE 318
K+P R TA +LL+H FI + K S L +LI K++ H E+ + + + E
Sbjct: 252 NKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSDIDGEAE 311
Query: 319 D 319
D
Sbjct: 312 D 312
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 266 bits (680), Expect = 3e-71
Identities = 143/376 (38%), Positives = 222/376 (59%), Gaps = 16/376 (4%)
Query: 23 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD--LQEIIKEISIMQQCDSP 80
P EV++++ +LG+G++G V+KA +KE+G + A K + +S+ L++ I EI I+ CD P
Sbjct: 32 PNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHP 91
Query: 81 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFM 140
Y+VK G+Y+ + LWI++E+C G+V I+ ++ L E +I + + L+ L +LH
Sbjct: 92 YIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSK 151
Query: 141 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----QE 195
R IHRD+KAGN+L+ EG +LADFGV+ + T+ KR++ IGTP+WMAPEV+ ++
Sbjct: 152 RIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKD 211
Query: 196 IGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFV 255
Y+ ADIWSLGIT IEMA+ +PP+ +++PMR + I + PPT P WS +F DF+
Sbjct: 212 TPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFL 271
Query: 256 KKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEEN 315
K L KNPE R +A QLL+HPF+ + LR+L+ EA + E+ + E EEE+
Sbjct: 272 KIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAV 331
Query: 316 SDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEE 375
L++HT + V S ++ A + E T + + + +E +
Sbjct: 332 DAASTLENHTQNSSEV-SPPSLNADKPLEESPSTPLAPSQSQDSV--------NEPCSQP 382
Query: 376 DGTMKRNATSPQVQRP 391
G TSP V P
Sbjct: 383 SGDRSLQTTSPPVVAP 398
Score = 33.5 bits (75), Expect = 0.45
Identities = 45/222 (20%), Positives = 88/222 (39%), Gaps = 26/222 (11%)
Query: 282 KPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATS 341
K +LRD EA + + H+ Q+R +++ D+ L H +++ + M+ +
Sbjct: 731 KKQELLRD--REAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYN 788
Query: 342 TMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNAT------SPQVQRPSFMD 395
Q MIE + + + E + M + + S QR
Sbjct: 789 ------QRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQ 842
Query: 396 YFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDG--DFDFLKN----LSLEELQ 449
+ +++ + KS Q HE N D + + L+N L +E
Sbjct: 843 FSQQEEKRQKSERLQQQQKHE------NQMRDMLAQCESNMSELQQLQNEKCHLLVEHET 896
Query: 450 MRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQQNF 491
+LKALD + ++E R + +++ + + ++ KKR Q+ F
Sbjct: 897 QKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMF 938
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 265 bits (678), Expect = 5e-71
Identities = 139/291 (47%), Positives = 193/291 (66%), Gaps = 16/291 (5%)
Query: 23 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV-PVESDLQEIIKEISIMQQC-DSP 80
P + +++ E +G+G+YG VFK ++K++GQ A+K + P+ +EI E +I++ D P
Sbjct: 17 PSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDHP 76
Query: 81 YVVKYYGSYFK----NTD-LWIVMEYCGAGSVSDIIR---LRNKTLIEDEIATILKSTLK 132
VV++YG YFK N D LW+V+E C GSV+D+++ R + + E IA IL L
Sbjct: 77 NVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALM 136
Query: 133 GLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV 192
GL++LH + IHRD+K NILL TEG KL DFGV+ QLT T +RNT +GTPFWMAPEV
Sbjct: 137 GLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEV 196
Query: 193 IQ-----EIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELW 247
I + Y+ D WSLGIT+IE+ +G PP AD+HPMRA+F IP NPPP R+PELW
Sbjct: 197 IACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELW 256
Query: 248 SDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSI-LRDLITEAMEI 297
S +F DF+ KCL K+ E+R T ++LLQH FI + + L+ +TE + I
Sbjct: 257 SAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQKQLTEFIGI 307
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 260 bits (665), Expect = 2e-69
Identities = 149/338 (44%), Positives = 208/338 (61%), Gaps = 24/338 (7%)
Query: 6 APKSKLKKLSEDSLT--KQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD 63
A S + L E L+ + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D
Sbjct: 2 ASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD 61
Query: 64 LQEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LR 114
+E IK EI+++++ + YYG++ K LW+VME+CGAGSV+D+I+ +
Sbjct: 62 EEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK 121
Query: 115 NKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT 174
TL E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T
Sbjct: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 175 MAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRA 229
+ +RNT IGTP+WMAPEVI + Y+ +D+WSLGIT+IEMAEG PP D+HPMRA
Sbjct: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
Query: 230 IFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI 286
+F+IP NP P K + WS F F++ CLVKN QR QL++HPFI+ N + V I
Sbjct: 242 LFLIPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 287 -LRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDS 323
L+D I K KR E+ + E E +E+E DS
Sbjct: 301 QLKDHIDRT---KKKRGEKDETEYEYSGSEEEEEENDS 335
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 260 bits (665), Expect = 2e-69
Identities = 149/338 (44%), Positives = 208/338 (61%), Gaps = 24/338 (7%)
Query: 6 APKSKLKKLSEDSLT--KQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD 63
A S + L E L+ + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D
Sbjct: 2 ASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD 61
Query: 64 LQEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LR 114
+E IK EI+++++ + YYG++ K LW+VME+CGAGSV+D+I+ +
Sbjct: 62 EEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK 121
Query: 115 NKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT 174
TL E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T
Sbjct: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 175 MAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRA 229
+ +RNT IGTP+WMAPEVI + Y+ +D+WSLGIT+IEMAEG PP D+HPMRA
Sbjct: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
Query: 230 IFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI 286
+F+IP NP P K + WS F F++ CLVKN QR QL++HPFI+ N + V I
Sbjct: 242 LFLIPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 287 -LRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDS 323
L+D I K KR E+ + E E +E+E DS
Sbjct: 301 QLKDHIDRT---KKKRGEKDETEYEYSGSEEEEEENDS 335
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 260 bits (665), Expect = 2e-69
Identities = 149/338 (44%), Positives = 208/338 (61%), Gaps = 24/338 (7%)
Query: 6 APKSKLKKLSEDSLT--KQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD 63
A S + L E L+ + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D
Sbjct: 2 ASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD 61
Query: 64 LQEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LR 114
+E IK EI+++++ + YYG++ K LW+VME+CGAGSV+D+I+ +
Sbjct: 62 EEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK 121
Query: 115 NKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT 174
TL E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T
Sbjct: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 175 MAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRA 229
+ +RNT IGTP+WMAPEVI + Y+ +D+WSLGIT+IEMAEG PP D+HPMRA
Sbjct: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
Query: 230 IFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI 286
+F+IP NP P K + WS F F++ CLVKN QR QL++HPFI+ N + V I
Sbjct: 242 LFLIPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 287 -LRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDS 323
L+D I K KR E+ + E E +E+E DS
Sbjct: 301 QLKDHIDRT---KKKRGEKDETEYEYSGSEEEEEENDS 335
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 260 bits (665), Expect = 2e-69
Identities = 149/338 (44%), Positives = 208/338 (61%), Gaps = 24/338 (7%)
Query: 6 APKSKLKKLSEDSLT--KQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD 63
A S + L E L+ + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D
Sbjct: 2 ASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD 61
Query: 64 LQEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LR 114
+E IK EI+++++ + YYG++ K LW+VME+CGAGSV+D+I+ +
Sbjct: 62 EEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK 121
Query: 115 NKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT 174
TL E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T
Sbjct: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 175 MAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRA 229
+ +RNT IGTP+WMAPEVI + Y+ +D+WSLGIT+IEMAEG PP D+HPMRA
Sbjct: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
Query: 230 IFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI 286
+F+IP NP P K + WS F F++ CLVKN QR QL++HPFI+ N + V I
Sbjct: 242 LFLIPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 287 -LRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDS 323
L+D I K KR E+ + E E +E+E DS
Sbjct: 301 QLKDHIDRT---KKKRGEKDETEYEYSGSEEEEEENDS 335
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 260 bits (665), Expect = 2e-69
Identities = 149/338 (44%), Positives = 208/338 (61%), Gaps = 24/338 (7%)
Query: 6 APKSKLKKLSEDSLT--KQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD 63
A S + L E L+ + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D
Sbjct: 2 ASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD 61
Query: 64 LQEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LR 114
+E IK EI+++++ + YYG++ K LW+VME+CGAGSV+D+I+ +
Sbjct: 62 EEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK 121
Query: 115 NKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT 174
TL E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T
Sbjct: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 175 MAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRA 229
+ +RNT IGTP+WMAPEVI + Y+ +D+WSLGIT+IEMAEG PP D+HPMRA
Sbjct: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
Query: 230 IFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI 286
+F+IP NP P K + WS F F++ CLVKN QR QL++HPFI+ N + V I
Sbjct: 242 LFLIPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 287 -LRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDS 323
L+D I K KR E+ + E E +E+E DS
Sbjct: 301 QLKDHIDRT---KKKRGEKDETEYEYSGSEEEEEENDS 335
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 260 bits (665), Expect = 2e-69
Identities = 149/338 (44%), Positives = 208/338 (61%), Gaps = 24/338 (7%)
Query: 6 APKSKLKKLSEDSLT--KQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD 63
A S + L E L+ + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D
Sbjct: 2 ASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD 61
Query: 64 LQEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LR 114
+E IK EI+++++ + YYG++ K LW+VME+CGAGSV+D+I+ +
Sbjct: 62 EEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK 121
Query: 115 NKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT 174
TL E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T
Sbjct: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 175 MAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRA 229
+ +RNT IGTP+WMAPEVI + Y+ +D+WSLGIT+IEMAEG PP D+HPMRA
Sbjct: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
Query: 230 IFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI 286
+F+IP NP P K + WS F F++ CLVKN QR QL++HPFI+ N + V I
Sbjct: 242 LFLIPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 287 -LRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDS 323
L+D I K KR E+ + E E +E+E DS
Sbjct: 301 QLKDHIDRT---KKKRGEKDETEYEYSGSEEEEEENDS 335
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 260 bits (665), Expect = 2e-69
Identities = 149/338 (44%), Positives = 208/338 (61%), Gaps = 24/338 (7%)
Query: 6 APKSKLKKLSEDSLT--KQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD 63
A S + L E L+ + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D
Sbjct: 2 ASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD 61
Query: 64 LQEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LR 114
+E IK EI+++++ + YYG++ K LW+VME+CGAGSV+D+I+ +
Sbjct: 62 EEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK 121
Query: 115 NKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT 174
TL E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T
Sbjct: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 175 MAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRA 229
+ +RNT IGTP+WMAPEVI + Y+ +D+WSLGIT+IEMAEG PP D+HPMRA
Sbjct: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
Query: 230 IFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI 286
+F+IP NP P K + WS F F++ CLVKN QR QL++HPFI+ N + V I
Sbjct: 242 LFLIPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 287 -LRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDS 323
L+D I K KR E+ + E E +E+E DS
Sbjct: 301 QLKDHIDRT---KKKRGEKDETEYEYSGSEEEEEENDS 335
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 260 bits (665), Expect = 2e-69
Identities = 149/338 (44%), Positives = 208/338 (61%), Gaps = 24/338 (7%)
Query: 6 APKSKLKKLSEDSLT--KQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD 63
A S + L E L+ + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D
Sbjct: 2 ASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD 61
Query: 64 LQEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LR 114
+E IK EI+++++ + YYG++ K LW+VME+CGAGSV+D+I+ +
Sbjct: 62 EEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK 121
Query: 115 NKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT 174
TL E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T
Sbjct: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 175 MAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRA 229
+ +RNT IGTP+WMAPEVI + Y+ +D+WSLGIT+IEMAEG PP D+HPMRA
Sbjct: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
Query: 230 IFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI 286
+F+IP NP P K + WS F F++ CLVKN QR QL++HPFI+ N + V I
Sbjct: 242 LFLIPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 287 -LRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDS 323
L+D I K KR E+ + E E +E+E DS
Sbjct: 301 QLKDHIDRT---KKKRGEKDETEYEYSGSEEEEEENDS 335
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 259 bits (663), Expect = 3e-69
Identities = 150/384 (39%), Positives = 229/384 (59%), Gaps = 37/384 (9%)
Query: 10 KLKKLSEDSLTKQ---------PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV 60
K+ KL + KQ PE+ ++++ +LG+G++G V+KA +KE+ + A K +
Sbjct: 8 KIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDT 67
Query: 61 --ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTL 118
E +L++ + EI I+ CD P +VK +++ +LWI++E+C G+V ++ + L
Sbjct: 68 KSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPL 127
Query: 119 IEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKR 178
E +I + K TL L YLH + IHRD+KAGNIL +G KLADFGV+ + T T+ +R
Sbjct: 128 TESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRR 187
Query: 179 NTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMI 233
++ IGTP+WMAPEV+ ++ Y+ AD+WSLGIT IEMAE +PP+ +++PMR + I
Sbjct: 188 DSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKI 247
Query: 234 PTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPF--IKNAKPVSILRDLI 291
+ PPT +P WS +F DF+KKCL KN + R T +QLLQHPF + + KP+ R+LI
Sbjct: 248 AKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI---RELI 304
Query: 292 TEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMS--EGAQT 349
EA KA+ EE + EE+EE E+ S+ + RA+S +S +
Sbjct: 305 AEA---KAEVTEEVEDGKEEDEEEETEN----------SLPIPASKRASSDLSIASSEED 351
Query: 350 MIEHNSTMLES-DLGTMVINSEDE 372
+ N+ +LES T NSED+
Sbjct: 352 KLSQNACILESVSEKTERSNSEDK 375
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 259 bits (663), Expect = 3e-69
Identities = 152/351 (43%), Positives = 214/351 (60%), Gaps = 28/351 (7%)
Query: 6 APKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQ 65
+P L + SL + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D +
Sbjct: 5 SPAKSLVDIDLSSL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 66 EIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNK 116
E IK EI+++++ + YYG++ K + LW+VME+CGAGS++D+++ +
Sbjct: 64 EEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGN 123
Query: 117 TLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMA 176
TL ED IA I + L+GL +LH IHRDIK N+LL KL DFGV+ QL T+
Sbjct: 124 TLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183
Query: 177 KRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIF 231
+RNT IGTP+WMAPEVI + Y+ +D+WS GIT+IEMAEG PP D+HPMRA+F
Sbjct: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALF 243
Query: 232 MIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI-L 287
+IP NPPP K + WS F F++ CLVKN QR + QLL+HPFI+ N + V I L
Sbjct: 244 LIPRNPPPRL-KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQL 302
Query: 288 RDLITEAMEIKAKRHEEQQREL-----EEEEENSDEDELDSHTMVKTSVES 333
+D I + KR E+ + E EEEEE E E + ++V ES
Sbjct: 303 KDHIDRT---RKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGES 350
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 259 bits (663), Expect = 3e-69
Identities = 152/351 (43%), Positives = 214/351 (60%), Gaps = 28/351 (7%)
Query: 6 APKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQ 65
+P L + SL + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D +
Sbjct: 5 SPAKSLVDIDLSSL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 66 EIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNK 116
E IK EI+++++ + YYG++ K + LW+VME+CGAGS++D+++ +
Sbjct: 64 EEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGN 123
Query: 117 TLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMA 176
TL ED IA I + L+GL +LH IHRDIK N+LL KL DFGV+ QL T+
Sbjct: 124 TLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183
Query: 177 KRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIF 231
+RNT IGTP+WMAPEVI + Y+ +D+WS GIT+IEMAEG PP D+HPMRA+F
Sbjct: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALF 243
Query: 232 MIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI-L 287
+IP NPPP K + WS F F++ CLVKN QR + QLL+HPFI+ N + V I L
Sbjct: 244 LIPRNPPPRL-KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQL 302
Query: 288 RDLITEAMEIKAKRHEEQQREL-----EEEEENSDEDELDSHTMVKTSVES 333
+D I + KR E+ + E EEEEE E E + ++V ES
Sbjct: 303 KDHIDRT---RKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGES 350
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 259 bits (663), Expect = 3e-69
Identities = 152/351 (43%), Positives = 214/351 (60%), Gaps = 28/351 (7%)
Query: 6 APKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQ 65
+P L + SL + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D +
Sbjct: 5 SPAKSLVDIDLSSL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
Query: 66 EIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNK 116
E IK EI+++++ + YYG++ K + LW+VME+CGAGS++D+++ +
Sbjct: 64 EEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGN 123
Query: 117 TLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMA 176
TL ED IA I + L+GL +LH IHRDIK N+LL KL DFGV+ QL T+
Sbjct: 124 TLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183
Query: 177 KRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIF 231
+RNT IGTP+WMAPEVI + Y+ +D+WS GIT+IEMAEG PP D+HPMRA+F
Sbjct: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALF 243
Query: 232 MIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI-L 287
+IP NPPP K + WS F F++ CLVKN QR + QLL+HPFI+ N + V I L
Sbjct: 244 LIPRNPPPRL-KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQL 302
Query: 288 RDLITEAMEIKAKRHEEQQREL-----EEEEENSDEDELDSHTMVKTSVES 333
+D I + KR E+ + E EEEEE E E + ++V ES
Sbjct: 303 KDHIDRT---RKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGES 350
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 256 bits (654), Expect = 3e-68
Identities = 128/282 (45%), Positives = 187/282 (66%), Gaps = 8/282 (2%)
Query: 17 DSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE--SDLQEIIKEISIM 74
D + P+E F++++++G G+YG V+KA + +G++ AIK + +E D + +EI +M
Sbjct: 6 DLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMM 65
Query: 75 QQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGL 134
+ C P +V Y+GSY + LWI ME+CG GS+ DI + L E +IA + + TL+GL
Sbjct: 66 KDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGP-LSELQIAYVSRETLQGL 124
Query: 135 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI- 193
YLH K+HRDIK NILL GH KLADFGV+ Q+T T+AKR + IGTP+WMAPEV
Sbjct: 125 YYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAA 184
Query: 194 --QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPELWSD 249
++ GYN + D+W++GIT+IE+AE +PP D+HPMRA+F++ + PP + WS+
Sbjct: 185 VERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSN 244
Query: 250 DFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLI 291
F FVK L KNP++R TA +LLQHPF+ S+ +L+
Sbjct: 245 SFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELL 286
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 256 bits (653), Expect = 4e-68
Identities = 143/334 (42%), Positives = 204/334 (61%), Gaps = 18/334 (5%)
Query: 5 PAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDL 64
PAP L + +L + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D
Sbjct: 4 PAPARSLDDIDLSAL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE 62
Query: 65 QEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRN 115
+E IK EI+++++ + YYG++ K + LW+VME+CGAGSV+D+++ +
Sbjct: 63 EEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKG 122
Query: 116 KTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTM 175
L ED IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+
Sbjct: 123 NALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182
Query: 176 AKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAI 230
+RNT IGTP+WMAPEVI + Y+ +DIWSLGIT+IEMAEG PP D+HPMRA+
Sbjct: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRAL 242
Query: 231 FMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDL 290
F+IP NPPP K + WS F DF+ CL+K R QLL+ PFI++ +R
Sbjct: 243 FLIPRNPPPRL-KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQ 301
Query: 291 ITEAMEIKAKRHEEQQRELEEEEENSDEDELDSH 324
+ + I R + ++E E E + E+E DSH
Sbjct: 302 LKD--HIDRSRKKRGEKEETEYEYSGSEEEDDSH 333
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 256 bits (653), Expect = 4e-68
Identities = 143/334 (42%), Positives = 204/334 (61%), Gaps = 18/334 (5%)
Query: 5 PAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDL 64
PAP L + +L + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D
Sbjct: 4 PAPARSLDDIDLSAL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE 62
Query: 65 QEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRN 115
+E IK EI+++++ + YYG++ K + LW+VME+CGAGSV+D+++ +
Sbjct: 63 EEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKG 122
Query: 116 KTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTM 175
L ED IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+
Sbjct: 123 NALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182
Query: 176 AKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAI 230
+RNT IGTP+WMAPEVI + Y+ +DIWSLGIT+IEMAEG PP D+HPMRA+
Sbjct: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRAL 242
Query: 231 FMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDL 290
F+IP NPPP K + WS F DF+ CL+K R QLL+ PFI++ +R
Sbjct: 243 FLIPRNPPPRL-KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQ 301
Query: 291 ITEAMEIKAKRHEEQQRELEEEEENSDEDELDSH 324
+ + I R + ++E E E + E+E DSH
Sbjct: 302 LKD--HIDRSRKKRGEKEETEYEYSGSEEEDDSH 333
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 256 bits (653), Expect = 4e-68
Identities = 143/334 (42%), Positives = 204/334 (61%), Gaps = 18/334 (5%)
Query: 5 PAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDL 64
PAP L + +L + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D
Sbjct: 4 PAPARSLDDIDLSAL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE 62
Query: 65 QEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRN 115
+E IK EI+++++ + YYG++ K + LW+VME+CGAGSV+D+++ +
Sbjct: 63 EEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKG 122
Query: 116 KTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTM 175
L ED IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+
Sbjct: 123 NALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182
Query: 176 AKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAI 230
+RNT IGTP+WMAPEVI + Y+ +DIWSLGIT+IEMAEG PP D+HPMRA+
Sbjct: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRAL 242
Query: 231 FMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDL 290
F+IP NPPP K + WS F DF+ CL+K R QLL+ PFI++ +R
Sbjct: 243 FLIPRNPPPRL-KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQ 301
Query: 291 ITEAMEIKAKRHEEQQRELEEEEENSDEDELDSH 324
+ + I R + ++E E E + E+E DSH
Sbjct: 302 LKD--HIDRSRKKRGEKEETEYEYSGSEEEDDSH 333
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 256 bits (653), Expect = 4e-68
Identities = 143/334 (42%), Positives = 204/334 (61%), Gaps = 18/334 (5%)
Query: 5 PAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDL 64
PAP L + +L + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D
Sbjct: 4 PAPARSLDDIDLSAL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE 62
Query: 65 QEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRN 115
+E IK EI+++++ + YYG++ K + LW+VME+CGAGSV+D+++ +
Sbjct: 63 EEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKG 122
Query: 116 KTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTM 175
L ED IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+
Sbjct: 123 NALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182
Query: 176 AKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAI 230
+RNT IGTP+WMAPEVI + Y+ +DIWSLGIT+IEMAEG PP D+HPMRA+
Sbjct: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRAL 242
Query: 231 FMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDL 290
F+IP NPPP K + WS F DF+ CL+K R QLL+ PFI++ +R
Sbjct: 243 FLIPRNPPPRL-KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQ 301
Query: 291 ITEAMEIKAKRHEEQQRELEEEEENSDEDELDSH 324
+ + I R + ++E E E + E+E DSH
Sbjct: 302 LKD--HIDRSRKKRGEKEETEYEYSGSEEEDDSH 333
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 250 bits (639), Expect = 2e-66
Identities = 141/353 (39%), Positives = 212/353 (60%), Gaps = 25/353 (7%)
Query: 1 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV 60
ME P P + D L + P++ +++++++G G+YG V+KA + +G++ A+K + +
Sbjct: 1 MEAPLRPAA-------DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKL 53
Query: 61 E--SDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTL 118
E D I +EI ++++C +V Y+GSY LWI MEYCG GS+ DI + L
Sbjct: 54 EPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGP-L 112
Query: 119 IEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKR 178
E +IA + + TL+GL YLH K+HRDIK NILL G KLADFGVA ++T T+AKR
Sbjct: 113 SELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR 172
Query: 179 NTVIGTPFWMAPEVI---QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPT 235
+ IGTP+WMAPEV + GYN + DIW++GIT+IE+ E +PP D+HPMRA+F++
Sbjct: 173 KSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSK 232
Query: 236 N--PPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITE 293
+ PP + WS F +FVK L KNP++R TA +LL H F+ A+P + R L E
Sbjct: 233 SNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV--AQP-GLSRALAVE 289
Query: 294 AMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVG-TMRATSTMSE 345
++ K + E +D+D+ + H +++ ++ S RA T SE
Sbjct: 290 LLD-KVNNPDNHAHYTE-----ADDDDFEPHAIIRHTIRSTNRNARAERTASE 336
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 250 bits (639), Expect = 2e-66
Identities = 141/353 (39%), Positives = 212/353 (60%), Gaps = 25/353 (7%)
Query: 1 MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV 60
ME P P + D L + P++ +++++++G G+YG V+KA + +G++ A+K + +
Sbjct: 1 MEAPLRPAA-------DILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKL 53
Query: 61 E--SDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTL 118
E D I +EI ++++C +V Y+GSY LWI MEYCG GS+ DI + L
Sbjct: 54 EPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGP-L 112
Query: 119 IEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKR 178
E +IA + + TL+GL YLH K+HRDIK NILL G KLADFGVA ++T T+AKR
Sbjct: 113 SELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR 172
Query: 179 NTVIGTPFWMAPEVI---QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPT 235
+ IGTP+WMAPEV + GYN + DIW++GIT+IE+ E +PP D+HPMRA+F++
Sbjct: 173 KSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSK 232
Query: 236 N--PPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITE 293
+ PP + WS F +FVK L KNP++R TA +LL H F+ A+P + R L E
Sbjct: 233 SNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV--AQP-GLSRALAVE 289
Query: 294 AMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVG-TMRATSTMSE 345
++ K + E +D+D+ + H +++ ++ S RA T SE
Sbjct: 290 LLD-KVNNPDNHAHYTE-----ADDDDFEPHAIIRHTIRSTNRNARAERTASE 336
>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
Length = 1314
Score = 248 bits (633), Expect = 9e-66
Identities = 135/326 (41%), Positives = 199/326 (61%), Gaps = 27/326 (8%)
Query: 23 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIK-EISIMQQCDS-P 80
P + ++++E +G+G+YG V+K +K G + A+K + SD+ E I+ E +I+Q + P
Sbjct: 23 PTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNILQFLPNHP 82
Query: 81 YVVKYYGSYFK-----NTDLWIVMEYCGAGSVSDIIR--LR-NKTLIEDEIATILKSTLK 132
VVK+YG ++K LW+V+E C GSV+++++ LR + L E I+ IL L
Sbjct: 83 NVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALL 142
Query: 133 GLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV 192
GL++LH R IHRD+K NILL TEG KL DFGV+ QLT T +RNT +GTPFWMAPEV
Sbjct: 143 GLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEV 202
Query: 193 IQ-----EIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELW 247
I + Y+ D+WSLGIT+IE+ +G PP D+HP++ +F IP NPPPT PE W
Sbjct: 203 IACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPEKW 262
Query: 248 SDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAK-PVSILRDLITEAME-------IKA 299
++F F+ +CL+K+ E+R + T LL HPFIK V L+ + + ++ +
Sbjct: 263 CEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAK 322
Query: 300 KRHEEQQR----ELEEEEENSDEDEL 321
RHE +E+ E+ ED+L
Sbjct: 323 TRHERMHTRRPYHVEDAEKYCLEDDL 348
>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
Length = 1341
Score = 248 bits (633), Expect = 9e-66
Identities = 135/326 (41%), Positives = 199/326 (61%), Gaps = 27/326 (8%)
Query: 23 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIK-EISIMQQCDS-P 80
P + ++++E +G+G+YG V+K +K G + A+K + SD+ E I+ E +I+Q + P
Sbjct: 23 PTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNILQFLPNHP 82
Query: 81 YVVKYYGSYFK-----NTDLWIVMEYCGAGSVSDIIR--LR-NKTLIEDEIATILKSTLK 132
VVK+YG ++K LW+V+E C GSV+++++ LR + L E I+ IL L
Sbjct: 83 NVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALL 142
Query: 133 GLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV 192
GL++LH R IHRD+K NILL TEG KL DFGV+ QLT T +RNT +GTPFWMAPEV
Sbjct: 143 GLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEV 202
Query: 193 IQ-----EIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELW 247
I + Y+ D+WSLGIT+IE+ +G PP D+HP++ +F IP NPPPT PE W
Sbjct: 203 IACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPEKW 262
Query: 248 SDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAK-PVSILRDLITEAME-------IKA 299
++F F+ +CL+K+ E+R + T LL HPFIK V L+ + + ++ +
Sbjct: 263 CEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAK 322
Query: 300 KRHEEQQR----ELEEEEENSDEDEL 321
RHE +E+ E+ ED+L
Sbjct: 323 TRHERMHTRRPYHVEDAEKYCLEDDL 348
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 248 bits (632), Expect = 1e-65
Identities = 128/304 (42%), Positives = 191/304 (62%), Gaps = 8/304 (2%)
Query: 14 LSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE--SDLQEIIKEI 71
L D + P + F++L+++G G+YG V+KA + ++ A+K V ++ D+ + +EI
Sbjct: 3 LLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEI 62
Query: 72 SIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTL 131
+I+++C P VV Y GSY +N LWI ME+CG GS+ +I L E +IA + + L
Sbjct: 63 TILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGP-LEERQIAYVCREAL 121
Query: 132 KGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 191
KGL +LH KIHRDIK N+LL +G KLADFGV+G+LT ++AKR + IGTP+WMAPE
Sbjct: 122 KGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPE 181
Query: 192 VI---QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPEL 246
V ++ GYN + D+W+LGIT+IE+ E +PP +HPMRA+ ++ + PP R
Sbjct: 182 VAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTR 241
Query: 247 WSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQ 306
W+ +F F+K L KNP++R TA +LLQHPF P ++L L+ +A + +
Sbjct: 242 WTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPED 301
Query: 307 RELE 310
ELE
Sbjct: 302 CELE 305
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,354,524
Number of Sequences: 37866
Number of extensions: 903612
Number of successful extensions: 11347
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 801
Number of HSP's successfully gapped in prelim test: 174
Number of HSP's that attempted gapping in prelim test: 7165
Number of HSP's gapped (non-prelim): 2075
length of query: 491
length of database: 18,247,518
effective HSP length: 106
effective length of query: 385
effective length of database: 14,233,722
effective search space: 5479982970
effective search space used: 5479982970
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.