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Search of human proteins with 169163827
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169163827 PREDICTED: similar to UPF0634 protein KIAA1641
[Homo sapiens]
(475 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169163827 PREDICTED: similar to UPF0634 protein KIAA1641 [Hom... 940 0.0
gi|239741684 PREDICTED: ankyrin repeat domain 36 [Homo sapiens] 863 0.0
gi|124517695 ankyrin repeat domain 36B [Homo sapiens] 862 0.0
gi|239741673 PREDICTED: protein immuno-reactive with anti-PTH po... 828 0.0
gi|239747793 PREDICTED: protein immuno-reactive with anti-PTH po... 828 0.0
gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens] 450 e-126
gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo... 450 e-126
gi|239746016 PREDICTED: ankyrin repeat domain 62 isoform 1 [Homo... 448 e-126
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 421 e-118
gi|149363642 coiled-coil domain containing 144A [Homo sapiens] 334 9e-92
gi|115495445 ankyrin repeat domain 30A [Homo sapiens] 312 4e-85
gi|222537750 ankyrin repeat domain 30B [Homo sapiens] 305 6e-83
gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member ... 245 6e-65
gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member ... 245 6e-65
gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo sap... 226 3e-59
gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo sap... 226 3e-59
gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo sa... 226 3e-59
gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo sa... 223 2e-58
gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 188 1e-47
gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 188 1e-47
gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 188 1e-47
gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 177 1e-44
gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 177 1e-44
gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 177 1e-44
gi|239754871 PREDICTED: similar to Coiled-coil domain-containing... 124 2e-28
gi|239749410 PREDICTED: similar to Coiled-coil domain-containing... 124 2e-28
gi|239743545 PREDICTED: hypothetical protein XP_002342885 [Homo ... 124 2e-28
gi|169168964 PREDICTED: hypothetical protein LOC100131031 [Homo ... 108 1e-23
gi|169168628 PREDICTED: hypothetical protein LOC100131031 [Homo ... 108 1e-23
gi|169169551 PREDICTED: hypothetical protein LOC100131031 [Homo ... 108 1e-23
>gi|169163827 PREDICTED: similar to UPF0634 protein KIAA1641 [Homo
sapiens]
Length = 475
Score = 940 bits (2429), Expect = 0.0
Identities = 475/475 (100%), Positives = 475/475 (100%)
Query: 1 MHSPLYPKIYSCILSLLCFFLVTDCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLK 60
MHSPLYPKIYSCILSLLCFFLVTDCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLK
Sbjct: 1 MHSPLYPKIYSCILSLLCFFLVTDCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLK 60
Query: 61 NKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLR 120
NKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLR
Sbjct: 61 NKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLR 120
Query: 121 ITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARL 180
ITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARL
Sbjct: 121 ITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARL 180
Query: 181 RLDTDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENT 240
RLDTDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENT
Sbjct: 181 RLDTDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENT 240
Query: 241 TLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQE 300
TLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQE
Sbjct: 241 TLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQE 300
Query: 301 NLNSHVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEK 360
NLNSHVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEK
Sbjct: 301 NLNSHVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEK 360
Query: 361 MYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQN 420
MYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQN
Sbjct: 361 MYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQN 420
Query: 421 LQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREVSIKKNKYFSNFLK 475
LQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREVSIKKNKYFSNFLK
Sbjct: 421 LQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREVSIKKNKYFSNFLK 475
>gi|239741684 PREDICTED: ankyrin repeat domain 36 [Homo sapiens]
Length = 1524
Score = 863 bits (2231), Expect = 0.0
Identities = 436/443 (98%), Positives = 442/443 (99%)
Query: 24 DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHE 83
DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHE
Sbjct: 974 DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHE 1033
Query: 84 ILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSA 143
ILELEKELCSLRFAIQQEKKKRRNVEE+HQKVREKLRITEEQYRIEADVTKPIKPALKSA
Sbjct: 1034 ILELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKLRITEEQYRIEADVTKPIKPALKSA 1093
Query: 144 EVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIV 203
EVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRL+ DTIKNQNLEKKYLKDFEIV
Sbjct: 1094 EVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEKKYLKDFEIV 1153
Query: 204 KRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSY 263
KRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSY
Sbjct: 1154 KRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSY 1213
Query: 264 HCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVL 323
HCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVL
Sbjct: 1214 HCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVL 1273
Query: 324 KTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLK 383
KTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLK
Sbjct: 1274 KTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLK 1333
Query: 384 KQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNEL 443
KQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNEL
Sbjct: 1334 KQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNEL 1393
Query: 444 NHSKEKECQYEKEKAEREVSIKK 466
NHSKEKECQYEKEKAEREV++++
Sbjct: 1394 NHSKEKECQYEKEKAEREVAVRQ 1416
Score = 36.2 bits (82), Expect = 0.067
Identities = 52/236 (22%), Positives = 95/236 (40%), Gaps = 39/236 (16%)
Query: 59 LKNKASVLQKRISEKEEIKSQLK-------------HEILELEKELCSLR---FAIQQEK 102
LK KA V + SE ++ +SQ+K + +E ++ C L+ +QQ+
Sbjct: 1284 LKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQL 1343
Query: 103 KKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDE 162
RN + +K I Q R +A V K + + N+++ + E
Sbjct: 1344 DDARNKADNQEKA-----ILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKE 1398
Query: 163 KEDLLHENRLMQDEIA--RLRLDTDTIKNQNLEKKYLKD------------FEIVKRKHE 208
KE +E + E+A +L+ D + N+ K L D + ++K +
Sbjct: 1399 KE-CQYEKEKAEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLD 1457
Query: 209 DLQKALKRNGETLAKTIAC---YSGQLAALTDENTTLRSKLEKQRESRQRLETEMQ 261
++ + + L TI C G L E+ +R ++KQ + +RLE +Q
Sbjct: 1458 QMRSQFQEIQDQLTATIRCTKEMEGDTQKLEVEHVMMRKIIKKQDDQIERLEKILQ 1513
>gi|124517695 ankyrin repeat domain 36B [Homo sapiens]
Length = 1121
Score = 862 bits (2226), Expect = 0.0
Identities = 436/443 (98%), Positives = 441/443 (99%)
Query: 24 DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHE 83
DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHE
Sbjct: 571 DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHE 630
Query: 84 ILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSA 143
ILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSA
Sbjct: 631 ILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSA 690
Query: 144 EVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIV 203
EVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRL+ DTIKNQNLEKKYLKDFEIV
Sbjct: 691 EVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEKKYLKDFEIV 750
Query: 204 KRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSY 263
KRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSY
Sbjct: 751 KRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSY 810
Query: 264 HCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVL 323
CRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVL
Sbjct: 811 RCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVL 870
Query: 324 KTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLK 383
KTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLK
Sbjct: 871 KTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLK 930
Query: 384 KQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNEL 443
KQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNEL
Sbjct: 931 KQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNEL 990
Query: 444 NHSKEKECQYEKEKAEREVSIKK 466
NHSKEKECQYEKEKAEREV++++
Sbjct: 991 NHSKEKECQYEKEKAEREVAVRQ 1013
Score = 36.2 bits (82), Expect = 0.067
Identities = 52/236 (22%), Positives = 95/236 (40%), Gaps = 39/236 (16%)
Query: 59 LKNKASVLQKRISEKEEIKSQLK-------------HEILELEKELCSLR---FAIQQEK 102
LK KA V + SE ++ +SQ+K + +E ++ C L+ +QQ+
Sbjct: 881 LKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQL 940
Query: 103 KKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDE 162
RN + +K I Q R +A V K + + N+++ + E
Sbjct: 941 DDARNKADNQEKA-----ILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKE 995
Query: 163 KEDLLHENRLMQDEIA--RLRLDTDTIKNQNLEKKYLKD------------FEIVKRKHE 208
KE +E + E+A +L+ D + N+ K L D + ++K +
Sbjct: 996 KE-CQYEKEKAEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLD 1054
Query: 209 DLQKALKRNGETLAKTIAC---YSGQLAALTDENTTLRSKLEKQRESRQRLETEMQ 261
++ + + L TI C G L E+ +R ++KQ + +RLE +Q
Sbjct: 1055 QMRSQFQEIQDQLTATIRCTKEMEGDTQKLEVEHVMMRKIIKKQDDQIERLEKILQ 1110
>gi|239741673 PREDICTED: protein immuno-reactive with anti-PTH
polyclonal antibodies [Homo sapiens]
Length = 1430
Score = 828 bits (2140), Expect = 0.0
Identities = 421/443 (95%), Positives = 432/443 (97%)
Query: 24 DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHE 83
DCVHLLKIK TFCL KRL +LKDNHCEQLRVKIRKLKNKASVLQKR+SEKEEIKSQLKHE
Sbjct: 880 DCVHLLKIKKTFCLCKRLTELKDNHCEQLRVKIRKLKNKASVLQKRLSEKEEIKSQLKHE 939
Query: 84 ILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSA 143
LELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSA
Sbjct: 940 TLELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSA 999
Query: 144 EVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIV 203
EVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRL+ DTIKNQNLEKKYLKDFEIV
Sbjct: 1000 EVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEKKYLKDFEIV 1059
Query: 204 KRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSY 263
KRKHEDLQKALKRN ETLA+TIACYSGQLAALTDENTTLRSKLEKQRES QRLETEMQSY
Sbjct: 1060 KRKHEDLQKALKRNEETLAETIACYSGQLAALTDENTTLRSKLEKQRESGQRLETEMQSY 1119
Query: 264 HCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVL 323
CRLNAA CDHDQSHSSKRDQELAFQGTVDKC HLQENLNSHVLILSLQLSKAESK RVL
Sbjct: 1120 RCRLNAALCDHDQSHSSKRDQELAFQGTVDKCCHLQENLNSHVLILSLQLSKAESKFRVL 1179
Query: 324 KTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLK 383
+TELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLK
Sbjct: 1180 ETELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLK 1239
Query: 384 KQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNEL 443
KQNMLLQQQLDDARNKADNQEKAILNIQARCDARV+NLQAECRKHRLLLEEDNKMLVNEL
Sbjct: 1240 KQNMLLQQQLDDARNKADNQEKAILNIQARCDARVENLQAECRKHRLLLEEDNKMLVNEL 1299
Query: 444 NHSKEKECQYEKEKAEREVSIKK 466
NHSKEK+CQYEKEKAEREV++++
Sbjct: 1300 NHSKEKKCQYEKEKAEREVAVRQ 1322
Score = 36.6 bits (83), Expect = 0.051
Identities = 45/213 (21%), Positives = 89/213 (41%), Gaps = 14/213 (6%)
Query: 56 IRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEELHQKV 115
I K+ ++ EK+E QLK + + L+++L R ++K N++
Sbjct: 1214 IEKMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDAR 1273
Query: 116 REKLRITEEQYRI--EADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLM 173
E L+ ++R+ E D + S E + + E E+E + + +
Sbjct: 1274 VENLQAECRKHRLLLEEDNKMLVNELNHSKEKKCQ-------YEKEKAEREVAVRQLQQK 1326
Query: 174 QDEIARLRLDTDTIKNQNLEKK-YLKD-FEIVKRKHEDLQKALKRNGETLAKTIAC---Y 228
QD++ R T + + + YL++ + ++K + ++ + + L TI C
Sbjct: 1327 QDDVLNKRSATKALLDASSRHCIYLENGMQDSRKKLDQMRSQFQEIQDQLTATIRCTKEM 1386
Query: 229 SGQLAALTDENTTLRSKLEKQRESRQRLETEMQ 261
G L EN +R ++KQ E +R E +Q
Sbjct: 1387 EGDAQKLEVENVMMRKIIKKQDEQIERFEKILQ 1419
>gi|239747793 PREDICTED: protein immuno-reactive with anti-PTH
polyclonal antibodies [Homo sapiens]
Length = 868
Score = 828 bits (2138), Expect = 0.0
Identities = 421/443 (95%), Positives = 431/443 (97%)
Query: 24 DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHE 83
DCVHLLKIK TFCL KRL +LKDNHCEQLRVKIRKLKNKASVLQKR+SEKEEIKSQLKHE
Sbjct: 318 DCVHLLKIKKTFCLCKRLTELKDNHCEQLRVKIRKLKNKASVLQKRLSEKEEIKSQLKHE 377
Query: 84 ILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSA 143
LELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSA
Sbjct: 378 TLELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSA 437
Query: 144 EVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIV 203
EVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRL+ DTIKNQNLEKKYLKDFEIV
Sbjct: 438 EVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEKKYLKDFEIV 497
Query: 204 KRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSY 263
KRKHEDLQKALKRN ETLA+TIACYSGQLAALTDENTTLRSKLEKQRES QRLETEMQSY
Sbjct: 498 KRKHEDLQKALKRNEETLAETIACYSGQLAALTDENTTLRSKLEKQRESGQRLETEMQSY 557
Query: 264 HCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVL 323
CRLNAA CDHDQSHSSKRDQELAFQGTVDKC HLQENLNSHVLILSLQLSKAESK RVL
Sbjct: 558 RCRLNAALCDHDQSHSSKRDQELAFQGTVDKCCHLQENLNSHVLILSLQLSKAESKFRVL 617
Query: 324 KTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLK 383
+TELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLK
Sbjct: 618 ETELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLK 677
Query: 384 KQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNEL 443
KQNMLLQQQLDDARNKADNQEKAILNIQARCDARV+NLQAECRKHRLLLEEDNKMLVNEL
Sbjct: 678 KQNMLLQQQLDDARNKADNQEKAILNIQARCDARVENLQAECRKHRLLLEEDNKMLVNEL 737
Query: 444 NHSKEKECQYEKEKAEREVSIKK 466
HSKEKECQYEKEKAEREV++++
Sbjct: 738 THSKEKECQYEKEKAEREVAVRQ 760
Score = 38.1 bits (87), Expect = 0.018
Identities = 62/281 (22%), Positives = 110/281 (39%), Gaps = 50/281 (17%)
Query: 22 VTDCVHLLKIKNTFCLWKRLIKLKDNHCE--------QLRVKIRKLKNKASVLQKRISEK 73
V C HL + N+ L ++ L+ + E +L LK KA V + SE
Sbjct: 586 VDKCCHLQENLNSHVL---ILSLQLSKAESKFRVLETELHYTGEALKEKALVFEHVQSEL 642
Query: 74 EEIKSQLK-------------HEILELEKELCSLR---FAIQQEKKKRRNVEELHQKVRE 117
++ +SQ+K + +E ++ C L+ +QQ+ RN + +K
Sbjct: 643 KQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDDARNKADNQEKA-- 700
Query: 118 KLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEI 177
I Q R +A V K + + N+++ + EKE +E + E+
Sbjct: 701 ---ILNIQARCDARVENLQAECRKHRLLLEEDNKMLVNELTHSKEKE-CQYEKEKAEREV 756
Query: 178 A--RLRLDTDTIKNQNLEKKYLKD------------FEIVKRKHEDLQKALKRNGETLAK 223
A +L+ D + N+ K L D + ++K + ++ + + L
Sbjct: 757 AVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLDQMRSQFQEIQDQLTA 816
Query: 224 TIAC---YSGQLAALTDENTTLRSKLEKQRESRQRLETEMQ 261
TI C G L EN +R ++KQ E +R E +Q
Sbjct: 817 TIRCTKEMEGDAQKLEVENVMMRKIIKKQDEQIERFEKILQ 857
>gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens]
Length = 917
Score = 450 bits (1158), Expect = e-126
Identities = 248/446 (55%), Positives = 317/446 (71%), Gaps = 11/446 (2%)
Query: 24 DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHE 83
D V L K KN R I+ + +CE+L+VK +K+KN SVLQK +SE ++ KSQ +H+
Sbjct: 414 DFVSLSKSKNATAACGRSIEDQKCYCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQ 473
Query: 84 ILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSA 143
L+ +K+LC+LRF +QQ++++R EEL++K E+L+I EEQYR + +V K K LKS
Sbjct: 474 NLQGKKKLCNLRFILQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSL 533
Query: 144 EVELKTGGNNSNQVSETDEKE-DLLHENRLMQDEIARLRLDTDTIKNQN--LEKKYLKDF 200
EVELKT +NSNQ T E+E DL EN LM+DEIARLRL+ DTIK+QN E KY KD
Sbjct: 534 EVELKTVRSNSNQNFHTHERERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKDI 593
Query: 201 EIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEM 260
EI+K +EDL+K LKRN ETL KTI YS +L L DENT L S+L+K+++S RLETEM
Sbjct: 594 EIIKENNEDLEKTLKRNEETLTKTITRYSKELNVLMDENTMLNSELQKEKQSMSRLETEM 653
Query: 261 QSYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKS 320
+SY CRL AA CDHDQ SSKRD +LAFQ TV++ HLQE+ NSH+ ILS QLSKAES S
Sbjct: 654 ESYRCRLAAALCDHDQRQSSKRDLQLAFQSTVNEWCHLQEDTNSHIQILSQQLSKAESTS 713
Query: 321 RVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQER-- 378
L+TELHY EALKEK L EH+Q L + Q +++DIE MY++ +EK + KQ+
Sbjct: 714 SGLETELHYEREALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVE 773
Query: 379 --FCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDN 436
QL+ QN+L QQQ +DAR KADNQEK I+NIQ +C+ V+ LQAECRK LEE+N
Sbjct: 774 DGLFQLQSQNLLYQQQCNDARKKADNQEKTIINIQVKCEDTVEKLQAECRK----LEENN 829
Query: 437 KMLVNELNHSKEKECQYEKEKAEREV 462
K L+ E KE++CQYEKEK EREV
Sbjct: 830 KGLMKECTLLKERQCQYEKEKEEREV 855
Score = 31.6 bits (70), Expect = 1.6
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 1/77 (1%)
Query: 43 KLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEK 102
KL++N+ + L + LK + +K E+E ++ QL+ E+ + + L ++
Sbjct: 824 KLEENN-KGLMKECTLLKERQCQYEKEKEEREVVRRQLQREVDDALNKQLLLEAMLEISS 882
Query: 103 KKRRNVEELHQKVREKL 119
++R N+E+ Q +++KL
Sbjct: 883 ERRINLEDEAQSLKKKL 899
>gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo
sapiens]
Length = 917
Score = 450 bits (1158), Expect = e-126
Identities = 248/446 (55%), Positives = 317/446 (71%), Gaps = 11/446 (2%)
Query: 24 DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHE 83
D V L K KN R I+ + +CE+L+VK +K+KN SVLQK +SE ++ KSQ +H+
Sbjct: 414 DFVSLSKSKNATAACGRSIEDQKCYCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQ 473
Query: 84 ILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSA 143
L+ +K+LC+LRF +QQ++++R EEL++K E+L+I EEQYR + +V K K LKS
Sbjct: 474 NLQGKKKLCNLRFILQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSL 533
Query: 144 EVELKTGGNNSNQVSETDEKE-DLLHENRLMQDEIARLRLDTDTIKNQN--LEKKYLKDF 200
EVELKT +NSNQ T E+E DL EN LM+DEIARLRL+ DTIK+QN E KY KD
Sbjct: 534 EVELKTVRSNSNQNFHTHERERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKDI 593
Query: 201 EIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEM 260
EI+K +EDL+K LKRN ETL KTI YS +L L DENT L S+L+K+++S RLETEM
Sbjct: 594 EIIKENNEDLEKTLKRNEETLTKTITRYSKELNVLMDENTMLNSELQKEKQSMSRLETEM 653
Query: 261 QSYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKS 320
+SY CRL AA CDHDQ SSKRD +LAFQ TV++ HLQE+ NSH+ ILS QLSKAES S
Sbjct: 654 ESYRCRLAAALCDHDQRQSSKRDLQLAFQSTVNEWCHLQEDTNSHIQILSQQLSKAESTS 713
Query: 321 RVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQER-- 378
L+TELHY EALKEK L EH+Q L + Q +++DIE MY++ +EK + KQ+
Sbjct: 714 SGLETELHYEREALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVE 773
Query: 379 --FCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDN 436
QL+ QN+L QQQ +DAR KADNQEK I+NIQ +C+ V+ LQAECRK LEE+N
Sbjct: 774 DGLFQLQSQNLLYQQQCNDARKKADNQEKTIINIQVKCEDTVEKLQAECRK----LEENN 829
Query: 437 KMLVNELNHSKEKECQYEKEKAEREV 462
K L+ E KE++CQYEKEK EREV
Sbjct: 830 KGLMKECTLLKERQCQYEKEKEEREV 855
Score = 31.6 bits (70), Expect = 1.6
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 1/77 (1%)
Query: 43 KLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEK 102
KL++N+ + L + LK + +K E+E ++ QL+ E+ + + L ++
Sbjct: 824 KLEENN-KGLMKECTLLKERQCQYEKEKEEREVVRRQLQREVDDALNKQLLLEAMLEISS 882
Query: 103 KKRRNVEELHQKVREKL 119
++R N+E+ Q +++KL
Sbjct: 883 ERRINLEDEAQSLKKKL 899
>gi|239746016 PREDICTED: ankyrin repeat domain 62 isoform 1 [Homo
sapiens]
Length = 917
Score = 448 bits (1153), Expect = e-126
Identities = 247/446 (55%), Positives = 316/446 (70%), Gaps = 11/446 (2%)
Query: 24 DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHE 83
D V L K KN R I+ + +CE+L+VK +K+KN SVLQK +SE ++ KSQ +H+
Sbjct: 414 DFVSLSKSKNATAACGRSIEDQKCYCERLKVKFQKMKNNISVLQKVLSETDKTKSQSEHQ 473
Query: 84 ILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSA 143
L+ +K+LC+LRF +QQ++++R EEL++K E+L+I EEQYR + +V K K LKS
Sbjct: 474 NLQGKKKLCNLRFILQQQEEERIKAEELYEKDIEELKIMEEQYRTQTEVKKQSKLTLKSL 533
Query: 144 EVELKTGGNNSNQVSETDEKE-DLLHENRLMQDEIARLRLDTDTIKNQN--LEKKYLKDF 200
EVELKT +NSNQ T E+E DL EN LM+DEIARLRL+ DTIK+QN E KY KD
Sbjct: 534 EVELKTVRSNSNQNFHTHERERDLWQENHLMRDEIARLRLEIDTIKHQNQETENKYFKDI 593
Query: 201 EIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEM 260
EI+K +EDL+K LKRN E L KTI YS +L L DENT L S+L+K+++S RLETEM
Sbjct: 594 EIIKENNEDLEKTLKRNEEALTKTITRYSKELNVLMDENTMLNSELQKEKQSMSRLETEM 653
Query: 261 QSYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKS 320
+SY CRL AA CDHDQ SSKRD +LAFQ TV++ HLQE+ NSH+ ILS QLSKAES S
Sbjct: 654 ESYRCRLAAALCDHDQRQSSKRDLQLAFQSTVNEWCHLQEDTNSHIQILSQQLSKAESTS 713
Query: 321 RVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQER-- 378
L+TELHY EALKEK L EH+Q L + Q +++DIE MY++ +EK + KQ+
Sbjct: 714 SGLETELHYEREALKEKTLHIEHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVE 773
Query: 379 --FCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDN 436
QL+ QN+L QQQ +DAR KADNQEK I+NIQ +C+ V+ LQAECRK LEE+N
Sbjct: 774 DGLFQLQSQNLLYQQQCNDARKKADNQEKTIINIQVKCEDTVEKLQAECRK----LEENN 829
Query: 437 KMLVNELNHSKEKECQYEKEKAEREV 462
K L+ E KE++CQYEKEK EREV
Sbjct: 830 KGLMKECTLLKERQCQYEKEKEEREV 855
Score = 31.6 bits (70), Expect = 1.6
Identities = 19/77 (24%), Positives = 42/77 (54%), Gaps = 1/77 (1%)
Query: 43 KLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEK 102
KL++N+ + L + LK + +K E+E ++ QL+ E+ + + L ++
Sbjct: 824 KLEENN-KGLMKECTLLKERQCQYEKEKEEREVVRRQLQREVDDALNKQLLLEAMLEISS 882
Query: 103 KKRRNVEELHQKVREKL 119
++R N+E+ Q +++KL
Sbjct: 883 ERRINLEDEAQSLKKKL 899
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 421 bits (1083), Expect = e-118
Identities = 238/503 (47%), Positives = 330/503 (65%), Gaps = 60/503 (11%)
Query: 24 DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHE 83
D V LLKI++ +RL++LK NHCE L VKI+K+++K +VLQ+ +SE +EIKSQL+H+
Sbjct: 721 DSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQ 780
Query: 84 ILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSA 143
+E E+ELCSLRF++ QE++KRRN + L++K+RE+LR EEQYR E +V + ++ +L++
Sbjct: 781 KVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTL 840
Query: 144 EVELKTGGNNSNQVSET------------------------------------------- 160
E+EL+T +N NQV +
Sbjct: 841 EMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSEN 900
Query: 161 ----DEKEDLLHENRLMQDEIARLRLDTDTIKNQN--LEKKYLKDFEIVKRKHEDLQKAL 214
+E++DL H+N ++Q+EIA LRL+ DTIKNQN EKK +D +IVK K+EDLQK +
Sbjct: 901 SHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTI 960
Query: 215 KRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDH 274
K+N ETL +TI+ Y+G+L+ LT EN L SKLE +++S++RLE E++SYH RL AA D
Sbjct: 961 KQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDR 1020
Query: 275 DQSHSSKRDQELAFQGTVDKCRHLQENLNSHVL-------ILSLQLSKAESKSRVLKTEL 327
DQS +SKR+ ELAFQ D+C LQ+ +N V ILS QL K ESK L+ E
Sbjct: 1021 DQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEF 1080
Query: 328 HYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQ----ERFCQLK 383
H+T +AL+EK L E VQ +L Q Q QMK++E+ Y++ + K I KQ ER QL+
Sbjct: 1081 HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQ 1140
Query: 384 KQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNEL 443
+NMLL+QQLDDA NKADN+EK ++NIQ + A VQ LQAE K LLLEE NK L++E
Sbjct: 1141 SENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISEC 1200
Query: 444 NHSKEKECQYEKEKAEREVSIKK 466
NH KE++ QYE EKAEREV +++
Sbjct: 1201 NHLKERQYQYENEKAEREVVVRQ 1223
Score = 62.0 bits (149), Expect = 1e-09
Identities = 85/433 (19%), Positives = 187/433 (43%), Gaps = 53/433 (12%)
Query: 44 LKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKK 103
L + ++L + LK + + +E+E + QL+ E+ + K+ +++ +
Sbjct: 1188 LLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSR 1247
Query: 104 KRRNVEELHQKVREKL-RITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDE 162
R N+E+ Q +++KL +I + + T+ ++ A K + + K +N+ +
Sbjct: 1248 YRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKK 1307
Query: 163 KEDLLHENRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIVKRKHE-DLQKALKRNGETL 221
+ D + E +Q + L D EK+ LK +K+ E +L + +K+N E
Sbjct: 1308 QMDKIEE---LQKNLLNANLSED-------EKEQLKKLMELKQSLECNLDQEMKKNVE-- 1355
Query: 222 AKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSK 281
L E T ++ L+ R+ E S+H L ++ + D
Sbjct: 1356 -------------LEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQ---- 1398
Query: 282 RDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVF 341
++K +H ++L + + + ++K+++L+ EL + + +++K
Sbjct: 1399 ----------INKLKHKIDDLTAELETAGSKCLHLDTKNQILQEEL-LSMKTVQKKCEKL 1447
Query: 342 EHVQSELKQKQSQMKD------IEKMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDD 395
+ + +L+Q+ ++ +E Y + +QE +LK+ N+ LQ Q
Sbjct: 1448 QKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAAS 1507
Query: 396 ARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEK 455
N +E +++++ + R+++L++E K + E+ NK EL K K+ E+
Sbjct: 1508 QENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNK---TEL--EKYKQLYLEE 1562
Query: 456 EKAEREVSIKKNK 468
K + +S K K
Sbjct: 1563 LKVRKSLSSKLTK 1575
Score = 32.3 bits (72), Expect = 0.96
Identities = 43/190 (22%), Positives = 86/190 (45%), Gaps = 31/190 (16%)
Query: 25 CVHLLKIKNTFCLWKRLIKLK--DNHCEQLRVKIRKLKNKASVLQKRISE---------- 72
C+HL KN L + L+ +K CE+L+ +KL+ + L+ I
Sbjct: 1420 CLHL-DTKNQI-LQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQ 1477
Query: 73 -KEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEELHQ------KVREKLRITEEQ 125
K+EI+ + + EI E KE + +Q + + N+E+ + K + +LRI + +
Sbjct: 1478 YKQEIEERARQEIAEKLKE---VNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLE 1534
Query: 126 YRI------EADVTKPIKPALKSAEV-ELKTGGNNSNQVSETDEKEDLLHENRLMQDEIA 178
+ + D K K + ELK + S+++++T+E+ ++ L++ + +
Sbjct: 1535 SELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQS 1594
Query: 179 RLRLDTDTIK 188
R T T +
Sbjct: 1595 RSLFTTLTTR 1604
>gi|149363642 coiled-coil domain containing 144A [Homo sapiens]
Length = 1427
Score = 334 bits (857), Expect = 9e-92
Identities = 209/498 (41%), Positives = 298/498 (59%), Gaps = 58/498 (11%)
Query: 24 DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHE 83
D L +I++TFCL + L+KLK+NHC+QL VK+++++N SVLQ +SE ++ K QL+ +
Sbjct: 631 DSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLELQ 690
Query: 84 ILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSA 143
+E EKEL LR A++QE +++RN + L+ K E+LRI EE+ + + +K L+
Sbjct: 691 KIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRL 750
Query: 144 EVELKTGGNN-------------------------------------------SNQVSET 160
EL+T NN ++++S
Sbjct: 751 VKELRTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHR 810
Query: 161 DEKE-DLLHENRLMQDEIARLRLDTDTIKNQN--LEKKYLKDFEIVKRKHEDLQKALKRN 217
+KE DL HE+ ++Q+EIA LRL+ DTIKNQN EKKY +D E VK K+++LQK +K N
Sbjct: 811 HQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLN 870
Query: 218 GETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQS 277
ETL +TI YSGQL LT EN L S+LE +++++RLE EM+SY CRL AA D DQS
Sbjct: 871 EETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQS 930
Query: 278 HSSKRDQELAFQGT-------VDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYT 330
++ RD +L FQ T DK + L + ILS +LS AESK L+ +LH T
Sbjct: 931 QTA-RDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSNAESKINSLQIQLHNT 989
Query: 331 GEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQ----ERFCQLKKQN 386
+AL ++L+ E VQ +L Q Q Q K+ E+MY+ + ++K I KQ ER QL+ +N
Sbjct: 990 RDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQLQSEN 1049
Query: 387 MLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHS 446
MLL+QQLDDA KA++QEK IQ + + +NLQAE K L L+E NK L++E NH
Sbjct: 1050 MLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHL 1109
Query: 447 KEKECQYEKEKAEREVSI 464
KE+ Q EKEKA R++ +
Sbjct: 1110 KERMDQCEKEKAGRKIDL 1127
Score = 55.5 bits (132), Expect = 1e-07
Identities = 88/409 (21%), Positives = 171/409 (41%), Gaps = 66/409 (16%)
Query: 103 KKRRNVEELHQKVREK----LRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVS 158
KK RN E + +++E L++T+ + + +LK L + +S++ S
Sbjct: 428 KKARNPEVVMVEMKEDQEFDLQMTKNMNQNSDSGSTNNYKSLKPKLENLSSLPPDSDRTS 487
Query: 159 ETDEKEDLLHENRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIVKRKHEDLQKALK--- 215
E E+L + + ++E+ L + +K ++++ KD E KH L
Sbjct: 488 EVYLHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLH--KDVEEEMEKHRSNSTELSGTL 545
Query: 216 RNGETLAKTIACYSGQLAA------------LTDENTTLRSKLEKQRESRQRLE-TEMQS 262
+G T+ + Q+ ++E +++++ + + +E +E+ S
Sbjct: 546 TDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIAS 605
Query: 263 YHCRLNAA------------RCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILS 310
C L+ + R ++ S S R Q+ T C HL + N+H L+
Sbjct: 606 EDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQD-----TFCLCEHLLKLKNNHCDQLT 660
Query: 311 LQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSEL-------KQKQSQMKDIEKMYK 363
++L + E+ VL+ EL T + + L + EL KQ+ + ++ + +Y
Sbjct: 661 VKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYN 720
Query: 364 SGYNTM----EKCIEKQERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQ 419
+ E+C + E QLK L ++L RN D L +Q R DA+ Q
Sbjct: 721 KDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLD------LVVQERNDAQKQ 774
Query: 420 NLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREVSIKKNK 468
L E+D ++L +++ SK+KE + ++K E+S + K
Sbjct: 775 ----------LSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQK 813
Score = 41.2 bits (95), Expect = 0.002
Identities = 81/450 (18%), Positives = 177/450 (39%), Gaps = 73/450 (16%)
Query: 50 EQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRR-NV 108
E+L+ ++K KN+ + L++ E L L+KE L +++E +K R N
Sbjct: 493 EELQQDMQKFKNEVNTLEE--------------EFLALKKEDVQLHKDVEEEMEKHRSNS 538
Query: 109 EELHQKVREKLRITEE--------------QYRIEADVTKPIKPALKS---AEVELKTGG 151
EL + + + + ++ AD T K +K+ E +
Sbjct: 539 TELSGTLTDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSM 598
Query: 152 NNSNQVSETDEKEDLLHENRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIVKRKHEDLQ 211
S SE E ++EN ++ E R+ D+ ++ + ++K K+
Sbjct: 599 EPSEIASEDCELSHSVYENFMLLIEQLRMEY-KDSASLPRIQDTFCLCEHLLKLKNNHCD 657
Query: 212 KALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAAR 271
+ + +L + + + L+++L + ++++ +LE + + L R
Sbjct: 658 Q---------------LTVKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLR 702
Query: 272 CDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLI---LSLQLSKAESKSRVLKTELH 328
Q + KR+ ++ + ++ R +E V L L + + R ++ L
Sbjct: 703 LALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLD 762
Query: 329 YTGEALKE-KALVFEHVQSELKQKQ---SQMKDIEKMYKSGYNTMEKCIEKQERF----C 380
+ + + + E + + Q Q S+ K++E K + + +K++ C
Sbjct: 763 LVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDC 822
Query: 381 QLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEE------ 434
L+++ LL+ ++D +N+ +EK + NLQ + + L E
Sbjct: 823 MLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYS 882
Query: 435 --------DNKMLVNELNHSKEKECQYEKE 456
+NK+L +EL + K+ + + E E
Sbjct: 883 GQLNNLTAENKILNSELENGKQNQERLEIE 912
Score = 40.8 bits (94), Expect = 0.003
Identities = 61/340 (17%), Positives = 136/340 (40%), Gaps = 32/340 (9%)
Query: 50 EQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVE 109
++++V + L+ K +L +++S E +I L+ +L + R A+ +E V+
Sbjct: 952 DKMKVDMSGLQAKNEILSEKLSNAES-------KINSLQIQLHNTRDALGRESLILERVQ 1004
Query: 110 ELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHE 169
+ + + + TE+ Y+IE K K K VE + S + + +D H+
Sbjct: 1005 RDLSQTQCQKKETEQMYQIEQSKLK--KYIAKQESVEERLSQLQSENMLLRQQLDDA-HK 1061
Query: 170 NRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYS 229
Q++ + D +NL+ + K ++ K+++L E + + +
Sbjct: 1062 KANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKA 1121
Query: 230 GQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQE---- 285
G+ LT+ T+ S+ + L+ + + + +C+ Q + + QE
Sbjct: 1122 GRKIDLTEAQETVPSRCLHLDAENEVLQLQQTLFSMKAIQKQCETLQKNKKQLKQEVVNL 1181
Query: 286 -------LAFQGTVD---------KCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHY 329
+ +G + + ++E LN IL+LQ A S ++++
Sbjct: 1182 KSYMERNMLERGKAEWHKLLIEERARKEIEEKLNE--AILTLQKQAAVSHEQLVQLREDN 1239
Query: 330 TGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTM 369
T + L + ++SE+ + ++ D K Y +
Sbjct: 1240 TTSIKTQMELTIKDLESEISRIKTSQADFNKTELERYKEL 1279
>gi|115495445 ankyrin repeat domain 30A [Homo sapiens]
Length = 1341
Score = 312 bits (800), Expect = 4e-85
Identities = 192/454 (42%), Positives = 286/454 (62%), Gaps = 27/454 (5%)
Query: 24 DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHE 83
D L KI +T +R +L+ +HCEQ K+ ++K K VL+K++SE +EIKSQL+++
Sbjct: 901 DSTSLSKILDTVHSCERARELQKDHCEQRTGKMEQMKKKFCVLKKKLSEAKEIKSQLENQ 960
Query: 84 ILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSA 143
++ E+ELCS+R + QE++KRRN + L++K+RE+L EEQ+R E +V + ++ AL+
Sbjct: 961 KVKWEQELCSVRLTLNQEEEKRRNADILNEKIREELGRIEEQHRKELEVKQQLEQALRIQ 1020
Query: 144 EVELKTGGNNSNQVSETDEKED-LLHENRLMQDEIARLRLDTDTIKNQNLEK--KYLKDF 200
++ELK+ +N NQVS T E E+ LLHEN +++ EIA L+L+ T+K+Q EK KY +D
Sbjct: 1021 DIELKSVESNLNQVSHTHENENYLLHENCMLKKEIAMLKLEIATLKHQYQEKENKYFEDI 1080
Query: 201 EIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEM 260
+I+K K+ +LQ LK E+L K + YSGQL L ENT L SKL K+++ ++ LE E+
Sbjct: 1081 KILKEKNAELQMTLKLKEESLTKRASQYSGQLKVLIAENTMLTSKL-KEKQDKEILEAEI 1139
Query: 261 QSYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVL-------ILSLQL 313
+S+H RL +A DHDQ +S++ QE AF D C LQ +N V +L L
Sbjct: 1140 ESHHPRLASAVQDHDQIVTSRKSQEPAFHIAGDAC--LQRKMNVDVSSTIYNNEVLHQPL 1197
Query: 314 SKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCI 373
S+A+ KS+ LK L+Y G+AL+E LV EH Q + ++ Q QMK+ E MY++ + + K
Sbjct: 1198 SEAQRKSKSLKINLNYAGDALRENTLVSEHAQRDQRETQCQMKEAEHMYQNEQDNVNKHT 1257
Query: 374 EKQE----RFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHR 429
E+QE + QL+ +NM LQQQL A KADN+ K ++I L+ + + H
Sbjct: 1258 EQQESLDQKLFQLQSKNMWLQQQLVHAHKKADNKSKITIDIHF--------LERKMQHH- 1308
Query: 430 LLLEEDNKMLVNELNHSKEKECQYEKEKAEREVS 463
LL+E N+ + N NH K + QYEKEKAE E S
Sbjct: 1309 -LLKEKNEEIFNYNNHLKNRIYQYEKEKAETENS 1341
>gi|222537750 ankyrin repeat domain 30B [Homo sapiens]
Length = 1392
Score = 305 bits (781), Expect = 6e-83
Identities = 197/469 (42%), Positives = 288/469 (61%), Gaps = 34/469 (7%)
Query: 21 LVTDCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQL 80
L D L KI + +R +LK ++CEQ+ K+ + KNK VLQK +SE +EIKSQL
Sbjct: 939 LRADSTTLSKILDALPSCERGRELKKDNCEQITAKMEQTKNKFCVLQKELSEAKEIKSQL 998
Query: 81 KHEILELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPAL 140
+++ + E+ELCS+R + QE++KRRNV+ L +K+R EEQ R + +V + ++ L
Sbjct: 999 ENQKAKWEQELCSVRLTLNQEEEKRRNVDILKEKIR-----PEEQLRKKLEVKQQLEQTL 1053
Query: 141 KSAEVELKTGGNNSNQVSETDEKE-DLLHENRLMQDEIARLRLDTDTIKNQN--LEKKYL 197
+ ++ELK+ +N NQVS T E E DL HEN +++ EIA L+L+ T+K+Q+ E KY
Sbjct: 1054 RIQDIELKSVTSNLNQVSHTHESENDLFHENCMLKKEIAMLKLEVATLKHQHQVKENKYF 1113
Query: 198 KDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLE 257
+D +I++ K+ +LQ LK +T+ K + Y QL LT ENT L SKL K+++ ++ LE
Sbjct: 1114 EDIKILQEKNAELQMTLKLKQKTVTKRASQYREQLKVLTAENTMLTSKL-KEKQDKEILE 1172
Query: 258 TEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVL-------ILS 310
TE++S+H RL +A DHDQS +S+++QELAF D LQ +N V +L
Sbjct: 1173 TEIESHHPRLASALQDHDQSVTSRKNQELAFHSAGD--APLQGIMNVDVSNTIYNNEVLH 1230
Query: 311 LQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTME 370
L +A+ KS+ K L+Y G+ L+E ALV EH Q + + Q QMK E MY++ + ++
Sbjct: 1231 QPLYEAQRKSKSPKINLNYAGDDLRENALVSEHAQRDRCETQCQMKKAEHMYQNEQDNVD 1290
Query: 371 KCIEKQE----RFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECR 426
K E+QE + QL+ +N L+QQL A K N+ K +NIQ + + +
Sbjct: 1291 KHTEQQESLEQKLFQLESKNRWLRQQLVYAHKKV-NKSKVTINIQFP--------EMKMQ 1341
Query: 427 KHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREVSIKKNKYFSNFLK 475
+H L E N+ + N NH KE+ QYEKEKAEREVSIKK KYFSNFLK
Sbjct: 1342 RH---LNEKNEEVFNYGNHLKERIDQYEKEKAEREVSIKKYKYFSNFLK 1387
>gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member A5
[Homo sapiens]
Length = 823
Score = 245 bits (626), Expect = 6e-65
Identities = 155/403 (38%), Positives = 238/403 (59%), Gaps = 26/403 (6%)
Query: 85 LELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAE 144
L+ E + C+L+ QE +++ NV LH+K RE+L E+QY+ E + K ++P ++S E
Sbjct: 433 LKEEHDRCTLK----QENEEKTNVNMLHKKNREELERKEKQYKKEVEA-KQLEPTVQSLE 487
Query: 145 VELKTGGNNSNQ-VSETDEKEDLLHENRLMQDEIARLRLDTDTIKNQNLEK--KYLKDFE 201
++ KT N NQ +E +DL+ EN +++ +IA LR + T+KN NLEK KYLKD +
Sbjct: 488 MKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIK 547
Query: 202 IVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQ 261
I K + L+K +K N E + KT Y +L L ENT L S+L K++ES+++LE E++
Sbjct: 548 IAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKKKLEAEIE 607
Query: 262 SYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQ-----ENLNSHVLILSLQLSKA 316
SY RL AA H ++ ++R+ +LA + T D ++ + L+ QLSK
Sbjct: 608 SYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKM 667
Query: 317 ESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEK- 375
+ K LK + T + L++K+L E VQ++L Q Q Q+K++++MY+S + K K
Sbjct: 668 QIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKW 727
Query: 376 ---QERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLL 432
+ER CQL+++N L+QQL D K D++E ++NIQ E RK L+L
Sbjct: 728 NCVEERICQLQRENPWLEQQLVDVHQKEDHKE-IVINIQRGF--------IESRKKDLML 778
Query: 433 EEDNKMLVNELNHSKEKECQYEKEKAEREVSIKKNKYFSNFLK 475
EE NK L+NE +H KE QYE++KAE VSIK++KYF K
Sbjct: 779 EEKNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQTSRK 821
>gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member A5
[Homo sapiens]
Length = 823
Score = 245 bits (626), Expect = 6e-65
Identities = 155/403 (38%), Positives = 238/403 (59%), Gaps = 26/403 (6%)
Query: 85 LELEKELCSLRFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAE 144
L+ E + C+L+ QE +++ NV LH+K RE+L E+QY+ E + K ++P ++S E
Sbjct: 433 LKEEHDRCTLK----QENEEKTNVNMLHKKNREELERKEKQYKKEVEA-KQLEPTVQSLE 487
Query: 145 VELKTGGNNSNQ-VSETDEKEDLLHENRLMQDEIARLRLDTDTIKNQNLEK--KYLKDFE 201
++ KT N NQ +E +DL+ EN +++ +IA LR + T+KN NLEK KYLKD +
Sbjct: 488 MKPKTARNTPNQDFHNHEEVKDLMDENCILKTDIAILRQEICTMKNDNLEKENKYLKDIK 547
Query: 202 IVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQ 261
I K + L+K +K N E + KT Y +L L ENT L S+L K++ES+++LE E++
Sbjct: 548 IAKETNAALEKCIKLNEEMITKTAFWYQQELNDLKAENTRLNSELLKEKESKKKLEAEIE 607
Query: 262 SYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQ-----ENLNSHVLILSLQLSKA 316
SY RL AA H ++ ++R+ +LA + T D ++ + L+ QLSK
Sbjct: 608 SYQSRLAAAISKHSENVKTERNLKLALERTQDISEQVKMSSDISEIEDKNXFLTEQLSKM 667
Query: 317 ESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEK- 375
+ K LK + T + L++K+L E VQ++L Q Q Q+K++++MY+S + K K
Sbjct: 668 QIKFNTLKDKFRKTRDTLRKKSLALETVQNDLSQTQQQIKEMKEMYQSAEAKVSKSTGKW 727
Query: 376 ---QERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLL 432
+ER CQL+++N L+QQL D K D++E ++NIQ E RK L+L
Sbjct: 728 NCVEERICQLQRENPWLEQQLVDVHQKEDHKE-IVINIQRGF--------IESRKKDLML 778
Query: 433 EEDNKMLVNELNHSKEKECQYEKEKAEREVSIKKNKYFSNFLK 475
EE NK L+NE +H KE QYE++KAE VSIK++KYF K
Sbjct: 779 EEKNKKLMNEYDHLKESLFQYERQKAETVVSIKEDKYFQTSRK 821
>gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo
sapiens]
Length = 823
Score = 226 bits (576), Expect = 3e-59
Identities = 151/444 (34%), Positives = 250/444 (56%), Gaps = 29/444 (6%)
Query: 47 NHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEI---LELEKELCSLRFAIQQEKK 103
N E++++ + +S R++++ +I + L+ E + C+L+ QE +
Sbjct: 392 NKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLK----QENE 447
Query: 104 KRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQ-VSETDE 162
++ NV L++K RE+L E+QY+ E + K ++P ++S E++ KT N N+ +E
Sbjct: 448 EKTNVNMLYKKNREELERKEKQYKKEVEA-KQLEPTVQSLEMKSKTARNTPNRDFHNHEE 506
Query: 163 KEDLLHENRLMQDEIARLRLDTDTIKNQNLEK--KYLKDFEIVKRKHEDLQKALKRNGET 220
+ L+ EN +++ +IA LR + T+KN NLEK KYLKD +IVK + L+K +K N E
Sbjct: 507 MKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEM 566
Query: 221 LAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSS 280
+ +T Y +L L ENT L ++L K++ES++RLE +++SY RL AA H +S +
Sbjct: 567 ITETAFRYQQELNYLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKT 626
Query: 281 KRDQELAFQGTVDKCRHLQ-----ENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALK 335
+R+ +LA + T D ++ + L+ QLS+ + K LK + T ++L+
Sbjct: 627 ERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLR 686
Query: 336 EKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEK----QERFCQLKKQNMLLQQ 391
+K+L E VQ++L Q Q Q +++++MY++ + K +ER C L+++N L Q
Sbjct: 687 KKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQ 746
Query: 392 QLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKEC 451
QLDD K D++E + NIQ E K L+LEE +K L+NE +H KE
Sbjct: 747 QLDDVHQKEDHKE-IVTNIQRGF--------IESGKKDLVLEEKSKKLMNECDHLKESLF 797
Query: 452 QYEKEKAEREVSIKKNKYFSNFLK 475
QYE+EK E VSIK++KYF K
Sbjct: 798 QYEREKTEGVVSIKEDKYFQTSRK 821
>gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo
sapiens]
Length = 823
Score = 226 bits (576), Expect = 3e-59
Identities = 151/444 (34%), Positives = 250/444 (56%), Gaps = 29/444 (6%)
Query: 47 NHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEI---LELEKELCSLRFAIQQEKK 103
N E++++ + +S R++++ +I + L+ E + C+L+ QE +
Sbjct: 392 NKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLK----QENE 447
Query: 104 KRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQ-VSETDE 162
++ NV L++K RE+L E+QY+ E + K ++P ++S E++ KT N N+ +E
Sbjct: 448 EKTNVNMLYKKNREELERKEKQYKKEVEA-KQLEPTVQSLEMKSKTARNTPNRDFHNHEE 506
Query: 163 KEDLLHENRLMQDEIARLRLDTDTIKNQNLEK--KYLKDFEIVKRKHEDLQKALKRNGET 220
+ L+ EN +++ +IA LR + T+KN NLEK KYLKD +IVK + L+K +K N E
Sbjct: 507 MKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEM 566
Query: 221 LAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSS 280
+ +T Y +L L ENT L ++L K++ES++RLE +++SY RL AA H +S +
Sbjct: 567 ITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKT 626
Query: 281 KRDQELAFQGTVDKCRHLQ-----ENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALK 335
+R+ +LA + T D ++ + L+ QLS+ + K LK + T ++L+
Sbjct: 627 ERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLR 686
Query: 336 EKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEK----QERFCQLKKQNMLLQQ 391
+K+L E VQ++L Q Q Q +++++MY++ + K +ER C L+++N L Q
Sbjct: 687 KKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQ 746
Query: 392 QLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKEC 451
QLDD K D++E + NIQ E K L+LEE +K L+NE +H KE
Sbjct: 747 QLDDVHQKEDHKE-IVTNIQRGF--------IESGKKDLVLEEKSKKLMNECDHLKESLF 797
Query: 452 QYEKEKAEREVSIKKNKYFSNFLK 475
QYE+EK E VSIK++KYF K
Sbjct: 798 QYEREKTEGVVSIKEDKYFQTSRK 821
>gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo
sapiens]
Length = 823
Score = 226 bits (576), Expect = 3e-59
Identities = 151/444 (34%), Positives = 250/444 (56%), Gaps = 29/444 (6%)
Query: 47 NHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEI---LELEKELCSLRFAIQQEKK 103
N E++++ + +S R++++ +I + L+ E + C+L+ QE +
Sbjct: 392 NKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLK----QENE 447
Query: 104 KRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSN-QVSETDE 162
++ NV L++K RE+L E+QY+ E + K ++P ++S E++ KT N N +E
Sbjct: 448 EKTNVNMLYKKNREELERKEKQYKKEVEA-KQLEPTVQSLEMKSKTARNTPNWDFHNHEE 506
Query: 163 KEDLLHENRLMQDEIARLRLDTDTIKNQNLEK--KYLKDFEIVKRKHEDLQKALKRNGET 220
+ L+ EN +++ +IA LR + T+KN NLEK KYLKD +IVK + L+K +K N E
Sbjct: 507 MKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEM 566
Query: 221 LAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSS 280
+ +T Y +L L ENT L ++L K++ES++RLE +++SY RL AA H +S +
Sbjct: 567 ITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKT 626
Query: 281 KRDQELAFQGTVDKCRHLQ-----ENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALK 335
+R+ +LA + T D ++ + + L+ QLS+ + K LK + T ++L+
Sbjct: 627 ERNLKLALERTRDVSVQVEMSSAISKVKAENEFLTEQLSETQIKFNALKDKFRKTRDSLR 686
Query: 336 EKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEK----QERFCQLKKQNMLLQQ 391
+K+L E VQ++L Q Q Q +++++MY++ + K +ER C L+++N L Q
Sbjct: 687 KKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQ 746
Query: 392 QLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKEC 451
QLDD K D++E + NIQ E K L+LEE +K L+NE +H KE
Sbjct: 747 QLDDVHQKEDHKE-IVTNIQRGF--------IESGKKDLVLEEKSKKLMNECDHLKESLF 797
Query: 452 QYEKEKAEREVSIKKNKYFSNFLK 475
QYE+EK E VSIK++KYF K
Sbjct: 798 QYEREKTEGVVSIKEDKYFQTSRK 821
>gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo
sapiens]
Length = 823
Score = 223 bits (569), Expect = 2e-58
Identities = 150/444 (33%), Positives = 247/444 (55%), Gaps = 29/444 (6%)
Query: 47 NHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEI---LELEKELCSLRFAIQQEKK 103
N E++++ + +S R++++ +I + L+ E + C+L+ QE +
Sbjct: 392 NKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLK----QENE 447
Query: 104 KRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSN-QVSETDE 162
++ NV L++K RE+L E+QY+ E + K ++P ++S E++ KT N N +E
Sbjct: 448 EKTNVNMLYKKNREELERKEKQYKKEVEA-KQLEPTVQSLEMKSKTARNTPNWDFHNHEE 506
Query: 163 KEDLLHENRLMQDEIARLRLDTDTIKNQNLEK--KYLKDFEIVKRKHEDLQKALKRNGET 220
+ L+ EN +++ +IA LR + T+KN NLEK KYLKD +IVK + L+K +K N E
Sbjct: 507 MKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEM 566
Query: 221 LAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSS 280
+ +T Y +L L ENT L ++L K++ES++RLE +++SY RL AA H +S +
Sbjct: 567 ITETAFRYQQELNDLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKT 626
Query: 281 KRDQELAFQGTVDKCRHLQ-----ENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALK 335
+R+ +LA + T D ++ + L+ QLS+ + K LK + T ++L+
Sbjct: 627 ERNLKLALERTQDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLR 686
Query: 336 EKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEK----QERFCQLKKQNMLLQQ 391
+K+L E VQ+ L Q Q Q +++++MY++ + K +ER C L+++N L Q
Sbjct: 687 KKSLALETVQNNLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQ 746
Query: 392 QLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKEC 451
QLDD K D++E + NIQ E K +LEE +K L+NE +H KE
Sbjct: 747 QLDDVHQKEDHKE-IVTNIQRGF--------IESGKKDFVLEEKSKKLMNECDHLKESLF 797
Query: 452 QYEKEKAEREVSIKKNKYFSNFLK 475
QYE+EK E VSIK++KYF K
Sbjct: 798 QYEREKTEVVVSIKEDKYFQTSRK 821
>gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1363
Score = 188 bits (477), Expect = 1e-47
Identities = 134/402 (33%), Positives = 228/402 (56%), Gaps = 32/402 (7%)
Query: 80 LKHEILELEKELCSLRFAIQQEKKKRRNVEELHQ-KVREKLRITEEQYRIEADVTKPIKP 138
++ +ILE + ++ ++ E L + K R+KL+ +E + E + +K
Sbjct: 347 IQQQILEHKNKMLKNHLRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAEHN----LKV 402
Query: 139 ALKSAEVELKTGGNNSNQVSET-DEKEDLLHENRLMQDEIARLRLDTDTIKNQNL--EKK 195
A + + L+ N Q S++ +K+D + N +++ +IA L+ + IKN +L EKK
Sbjct: 403 ASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSLRKEKK 462
Query: 196 YLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQR 255
Y+++ + + + + +K+++ N E + K +A YS QL L EN L SKLEK++ +++R
Sbjct: 463 YIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKER 522
Query: 256 LETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVL-------I 308
LE E++S H L A ++++ ++D EL D RH E + S++ +
Sbjct: 523 LEAEVESLHSNLATAINEYNEI-LERKDLELVLWRADDVSRH--ETMGSNISQLTDKNEL 579
Query: 309 LSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNT 368
L+ Q+ KA K LK +L T +AL+EK L E VQ +LKQ Q ++K++++M+ +G
Sbjct: 580 LTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAK 639
Query: 369 MEKCIEKQ----ERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAE 424
+ I KQ ER Q + +N+LL++QL+DAR + DN+E ++NI C ++N + +
Sbjct: 640 ESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKE-IVINIHRDC---LENGKED 695
Query: 425 CRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREVSIKK 466
LLEE NK L+NE N+ KEK QYEKEKAEREV +++
Sbjct: 696 ------LLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVRE 731
Score = 32.7 bits (73), Expect = 0.74
Identities = 53/290 (18%), Positives = 116/290 (40%), Gaps = 50/290 (17%)
Query: 75 EIKSQLKHEILELEKELCSL-RFAIQQEKKKRRNVEELHQKVREKLRIT--------EEQ 125
EI+ + KHE EL SL + Q +KK R +EE ++ L +T E
Sbjct: 774 EIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANED 833
Query: 126 YRIEADV-TKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLDT 184
+ D+ T +K + +++ K + + + + + +L +N ++ E+ +
Sbjct: 834 FSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLHQELLSMGKVQ 893
Query: 185 DTIKNQNLEKKYLKDFEIVKRKH-------------------EDLQKALKRNGETLAKTI 225
+ + +KK L++ + + H E +A+++ E +
Sbjct: 894 EKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIEKLEEIHLQKQ 953
Query: 226 ACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQE 285
A Y QL L +NT S ++ E ++ C+ + + ++ + + +
Sbjct: 954 AEYEKQLEQLNKDNTA----------SLKKKELTLKDVECKFSKMKTAYEDVTTELEEYK 1003
Query: 286 LAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALK 335
AF L+ N + +S +++K++ K V+ T+L E ++
Sbjct: 1004 EAFAVA------LKANSS-----MSEKITKSDKKIAVISTKLFMEKERME 1042
Score = 32.7 bits (73), Expect = 0.74
Identities = 40/158 (25%), Positives = 75/158 (47%), Gaps = 16/158 (10%)
Query: 32 KNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKR----ISEKEEIKSQLKHEILEL 87
K+ L ++++ LK H E+ V++ K++ S L +R I + EEI Q + E
Sbjct: 901 KDKKMLEEKVLNLK-THMEKDMVELGKVQEYKSELDERAMQAIEKLEEIHLQKQ---AEY 956
Query: 88 EKELCSL-RFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVE 146
EK+L L + KKK ++++ K K++ E DVT ++ ++ V
Sbjct: 957 EKQLEQLNKDNTASLKKKELTLKDVECKF-SKMKTAYE------DVTTELEEYKEAFAVA 1009
Query: 147 LKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLDT 184
LK + S +++++D+K ++ M+ E L T
Sbjct: 1010 LKANSSMSEKITKSDKKIAVISTKLFMEKERMEYFLST 1047
>gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1366
Score = 188 bits (477), Expect = 1e-47
Identities = 134/402 (33%), Positives = 228/402 (56%), Gaps = 32/402 (7%)
Query: 80 LKHEILELEKELCSLRFAIQQEKKKRRNVEELHQ-KVREKLRITEEQYRIEADVTKPIKP 138
++ +ILE + ++ ++ E L + K R+KL+ +E + E + +K
Sbjct: 376 IQQQILEHKNKMLKNHLRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAEHN----LKV 431
Query: 139 ALKSAEVELKTGGNNSNQVSET-DEKEDLLHENRLMQDEIARLRLDTDTIKNQNL--EKK 195
A + + L+ N Q S++ +K+D + N +++ +IA L+ + IKN +L EKK
Sbjct: 432 ASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSLRKEKK 491
Query: 196 YLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQR 255
Y+++ + + + + +K+++ N E + K +A YS QL L EN L SKLEK++ +++R
Sbjct: 492 YIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKER 551
Query: 256 LETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVL-------I 308
LE E++S H L A ++++ ++D EL D RH E + S++ +
Sbjct: 552 LEAEVESLHSNLATAINEYNEI-LERKDLELVLWRADDVSRH--ETMGSNISQLTDKNEL 608
Query: 309 LSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNT 368
L+ Q+ KA K LK +L T +AL+EK L E VQ +LKQ Q ++K++++M+ +G
Sbjct: 609 LTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAK 668
Query: 369 MEKCIEKQ----ERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAE 424
+ I KQ ER Q + +N+LL++QL+DAR + DN+E ++NI C ++N + +
Sbjct: 669 ESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKE-IVINIHRDC---LENGKED 724
Query: 425 CRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREVSIKK 466
LLEE NK L+NE N+ KEK QYEKEKAEREV +++
Sbjct: 725 ------LLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVRE 760
Score = 32.7 bits (73), Expect = 0.74
Identities = 53/290 (18%), Positives = 116/290 (40%), Gaps = 50/290 (17%)
Query: 75 EIKSQLKHEILELEKELCSL-RFAIQQEKKKRRNVEELHQKVREKLRIT--------EEQ 125
EI+ + KHE EL SL + Q +KK R +EE ++ L +T E
Sbjct: 803 EIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANED 862
Query: 126 YRIEADV-TKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLDT 184
+ D+ T +K + +++ K + + + + + +L +N ++ E+ +
Sbjct: 863 FSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLHQELLSMGKVQ 922
Query: 185 DTIKNQNLEKKYLKDFEIVKRKH-------------------EDLQKALKRNGETLAKTI 225
+ + +KK L++ + + H E +A+++ E +
Sbjct: 923 EKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIEKLEEIHLQKQ 982
Query: 226 ACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQE 285
A Y QL L +NT S ++ E ++ C+ + + ++ + + +
Sbjct: 983 AEYEKQLEQLNKDNTA----------SLKKKELTLKDVECKFSKMKTAYEDVTTELEEYK 1032
Query: 286 LAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALK 335
AF L+ N + +S +++K++ K V+ T+L E ++
Sbjct: 1033 EAFAVA------LKANSS-----MSEKITKSDKKIAVISTKLFMEKERME 1071
Score = 32.7 bits (73), Expect = 0.74
Identities = 40/158 (25%), Positives = 75/158 (47%), Gaps = 16/158 (10%)
Query: 32 KNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKR----ISEKEEIKSQLKHEILEL 87
K+ L ++++ LK H E+ V++ K++ S L +R I + EEI Q + E
Sbjct: 930 KDKKMLEEKVLNLK-THMEKDMVELGKVQEYKSELDERAMQAIEKLEEIHLQKQ---AEY 985
Query: 88 EKELCSL-RFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVE 146
EK+L L + KKK ++++ K K++ E DVT ++ ++ V
Sbjct: 986 EKQLEQLNKDNTASLKKKELTLKDVECKF-SKMKTAYE------DVTTELEEYKEAFAVA 1038
Query: 147 LKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLDT 184
LK + S +++++D+K ++ M+ E L T
Sbjct: 1039 LKANSSMSEKITKSDKKIAVISTKLFMEKERMEYFLST 1076
>gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1139
Score = 188 bits (477), Expect = 1e-47
Identities = 134/402 (33%), Positives = 228/402 (56%), Gaps = 32/402 (7%)
Query: 80 LKHEILELEKELCSLRFAIQQEKKKRRNVEELHQ-KVREKLRITEEQYRIEADVTKPIKP 138
++ +ILE + ++ ++ E L + K R+KL+ +E + E + +K
Sbjct: 376 IQQQILEHKNKMLKNHLRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAEHN----LKV 431
Query: 139 ALKSAEVELKTGGNNSNQVSET-DEKEDLLHENRLMQDEIARLRLDTDTIKNQNL--EKK 195
A + + L+ N Q S++ +K+D + N +++ +IA L+ + IKN +L EKK
Sbjct: 432 ASEEKQERLERSENKQPQDSQSYGKKKDEMFGNFMLKRDIAMLKEELYAIKNDSLRKEKK 491
Query: 196 YLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQR 255
Y+++ + + + + +K+++ N E + K +A YS QL L EN L SKLEK++ +++R
Sbjct: 492 YIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHNKER 551
Query: 256 LETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVL-------I 308
LE E++S H L A ++++ ++D EL D RH E + S++ +
Sbjct: 552 LEAEVESLHSNLATAINEYNEI-LERKDLELVLWRADDVSRH--ETMGSNISQLTDKNEL 608
Query: 309 LSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNT 368
L+ Q+ KA K LK +L T +AL+EK L E VQ +LKQ Q ++K++++M+ +G
Sbjct: 609 LTEQVHKARVKFNTLKGKLRETRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAK 668
Query: 369 MEKCIEKQ----ERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAE 424
+ I KQ ER Q + +N+LL++QL+DAR + DN+E ++NI C ++N + +
Sbjct: 669 ESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKE-IVINIHRDC---LENGKED 724
Query: 425 CRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREVSIKK 466
LLEE NK L+NE N+ KEK QYEKEKAEREV +++
Sbjct: 725 ------LLEERNKELMNEYNYLKEKLLQYEKEKAEREVIVRE 760
Score = 32.7 bits (73), Expect = 0.74
Identities = 53/290 (18%), Positives = 116/290 (40%), Gaps = 50/290 (17%)
Query: 75 EIKSQLKHEILELEKELCSL-RFAIQQEKKKRRNVEELHQKVREKLRIT--------EEQ 125
EI+ + KHE EL SL + Q +KK R +EE ++ L +T E
Sbjct: 803 EIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANED 862
Query: 126 YRIEADV-TKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLDT 184
+ D+ T +K + +++ K + + + + + +L +N ++ E+ +
Sbjct: 863 FSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLHQELLSMGKVQ 922
Query: 185 DTIKNQNLEKKYLKDFEIVKRKH-------------------EDLQKALKRNGETLAKTI 225
+ + +KK L++ + + H E +A+++ E +
Sbjct: 923 EKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIEKLEEIHLQKQ 982
Query: 226 ACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQE 285
A Y QL L +NT S ++ E ++ C+ + + ++ + + +
Sbjct: 983 AEYEKQLEQLNKDNTA----------SLKKKELTLKDVECKFSKMKTAYEDVTTELEEYK 1032
Query: 286 LAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALK 335
AF L+ N + +S +++K++ K V+ T+L E ++
Sbjct: 1033 EAFAVA------LKANSS-----MSEKITKSDKKIAVISTKLFMEKERME 1071
Score = 32.7 bits (73), Expect = 0.74
Identities = 40/158 (25%), Positives = 75/158 (47%), Gaps = 16/158 (10%)
Query: 32 KNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKR----ISEKEEIKSQLKHEILEL 87
K+ L ++++ LK H E+ V++ K++ S L +R I + EEI Q + E
Sbjct: 930 KDKKMLEEKVLNLK-THMEKDMVELGKVQEYKSELDERAMQAIEKLEEIHLQKQ---AEY 985
Query: 88 EKELCSL-RFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVE 146
EK+L L + KKK ++++ K K++ E DVT ++ ++ V
Sbjct: 986 EKQLEQLNKDNTASLKKKELTLKDVECKF-SKMKTAYE------DVTTELEEYKEAFAVA 1038
Query: 147 LKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLDT 184
LK + S +++++D+K ++ M+ E L T
Sbjct: 1039 LKANSSMSEKITKSDKKIAVISTKLFMEKERMEYFLST 1076
>gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 177 bits (450), Expect = 1e-44
Identities = 133/424 (31%), Positives = 231/424 (54%), Gaps = 29/424 (6%)
Query: 61 NKASVLQKRISEKEEIKSQ----LKHEILELEKELCSLRFAIQQEKKK--RRNVEELHQK 114
N +S++ + + I SQ E L +L S+R I + K K + ++ +Q+
Sbjct: 318 NLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQE 377
Query: 115 VREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSET-DEKEDLLHENRLM 173
++ + A +K A + + L+ N Q S++ +K+D ++ N ++
Sbjct: 378 TAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFML 437
Query: 174 QDEIARLRLDTDTIKNQNL--EKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQ 231
+ +IA L+ + IKN +L EKKY+++ + + + + +K+++ N + + KT+A YS Q
Sbjct: 438 KKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQ 497
Query: 232 LAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGT 291
L L EN L S+LEK++ +++RLE E++S H L A ++++ ++D EL
Sbjct: 498 LNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEI-VERKDLELVLWRA 556
Query: 292 VDKCRHLQENLNSHVL-----ILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQS 346
D RH + N L +L+ Q+ KA K LK +L T +AL+EK L VQ
Sbjct: 557 DDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQL 616
Query: 347 ELKQKQSQMKDIEKMYKSGYNTMEKCIEKQ----ERFCQLKKQNMLLQQQLDDARNKADN 402
+L+Q Q ++K++++M+ +G + I KQ ER Q + +N+LL++QL+DAR + DN
Sbjct: 617 DLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDN 676
Query: 403 QEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREV 462
+E ++NI C ++N + + LLEE NK L+ E N+ KEK Q EKEKAEREV
Sbjct: 677 KE-IVINIHRDC---LENGKED------LLEERNKELMKEYNYLKEKLLQCEKEKAEREV 726
Query: 463 SIKK 466
+++
Sbjct: 727 IVRE 730
Score = 38.9 bits (89), Expect = 0.010
Identities = 56/284 (19%), Positives = 121/284 (42%), Gaps = 38/284 (13%)
Query: 75 EIKSQLKHEILELEKELCSL-RFAIQQEKKKRRNVEELHQKVREKLRIT--------EEQ 125
EI+ + KHE EL SL + Q +KK R +EE ++ L +T E
Sbjct: 773 EIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANED 832
Query: 126 YRIEADV-TKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLDT 184
+ D+ T +K + +++ K + + + + E +L +N ++ E+ +R
Sbjct: 833 FSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQ 892
Query: 185 DTIKNQNLEKKYLKDFEIVKRKH-----EDLQKALKRNGETLAKTIACYSGQLAALTDEN 239
+ + +KK L++ + + H +L K + E + + ++ L + +
Sbjct: 893 EKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQ----EIEKLEEIH 948
Query: 240 TTLRSKLEKQRE--------SRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGT 291
+++ EKQ E S ++ E ++ C+ + + +++ + + + AF G
Sbjct: 949 LQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGA 1008
Query: 292 VDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALK 335
V + NS +S +L K++ K V+ T+L + +K
Sbjct: 1009 V-------KANNS----MSKKLMKSDKKIAVISTKLFTEKQRMK 1041
Score = 32.3 bits (72), Expect = 0.96
Identities = 84/398 (21%), Positives = 162/398 (40%), Gaps = 72/398 (18%)
Query: 45 KDNHCEQLRVKIRKLKNKASVLQKRISEKE----EIKSQLKHEILELEKELCSLRFAIQQ 100
K N E+ R++ ++L+N Q + KE EI + + LE KE + +
Sbjct: 645 KQNSLEE-RIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKE------DLLE 697
Query: 101 EKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSET 160
E+ K E + ++EKL E++ + + + L LKT + + + T
Sbjct: 698 ERNKELMKE--YNYLKEKLLQCEKEKAEREVIVREFQEELVD---HLKTFSISESPLEGT 752
Query: 161 DEKEDLLHENRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNGET 220
L+E + ++ ++ I+ + +++ K FE++ + + K+N E
Sbjct: 753 SHCHINLNETWTSKKKLFQVE-----IQPEEKHEEFRKLFELISLLNYTADQIRKKNREL 807
Query: 221 ------LAKTIACYSGQLAALTDENTTLRSKLE-------------KQRESRQRLETEMQ 261
K + L A +E+ + L KQ+ + E E
Sbjct: 808 EEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAV 867
Query: 262 SYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQE----------NLNSH-----V 306
S C +N A+ D++ H + L+ + +KC L++ NL +H V
Sbjct: 868 SSEC-VNLAK-DNEVLHQ----ELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMV 921
Query: 307 LILSLQLSKAESKSRVLKT-----ELHYTGEALKEKAL--VFEHVQSELKQKQSQMKDIE 359
+ LQ K+E R ++ E+H +A EK L + + + LK+K+ +KD+E
Sbjct: 922 ELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVE 981
Query: 360 KMY---KSGYNTMEKCIEK-QERFCQLKKQNMLLQQQL 393
+ K+ Y + +E+ +E F K N + ++L
Sbjct: 982 CKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKL 1019
>gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1002
Score = 177 bits (450), Expect = 1e-44
Identities = 133/424 (31%), Positives = 231/424 (54%), Gaps = 29/424 (6%)
Query: 61 NKASVLQKRISEKEEIKSQ----LKHEILELEKELCSLRFAIQQEKKK--RRNVEELHQK 114
N +S++ + + I SQ E L +L S+R I + K K + ++ +Q+
Sbjct: 211 NLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQE 270
Query: 115 VREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSET-DEKEDLLHENRLM 173
++ + A +K A + + L+ N Q S++ +K+D ++ N ++
Sbjct: 271 TAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFML 330
Query: 174 QDEIARLRLDTDTIKNQNL--EKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQ 231
+ +IA L+ + IKN +L EKKY+++ + + + + +K+++ N + + KT+A YS Q
Sbjct: 331 KKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQ 390
Query: 232 LAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGT 291
L L EN L S+LEK++ +++RLE E++S H L A ++++ ++D EL
Sbjct: 391 LNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEI-VERKDLELVLWRA 449
Query: 292 VDKCRHLQENLNSHVL-----ILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQS 346
D RH + N L +L+ Q+ KA K LK +L T +AL+EK L VQ
Sbjct: 450 DDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQL 509
Query: 347 ELKQKQSQMKDIEKMYKSGYNTMEKCIEKQ----ERFCQLKKQNMLLQQQLDDARNKADN 402
+L+Q Q ++K++++M+ +G + I KQ ER Q + +N+LL++QL+DAR + DN
Sbjct: 510 DLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDN 569
Query: 403 QEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREV 462
+E ++NI C ++N + + LLEE NK L+ E N+ KEK Q EKEKAEREV
Sbjct: 570 KE-IVINIHRDC---LENGKED------LLEERNKELMKEYNYLKEKLLQCEKEKAEREV 619
Query: 463 SIKK 466
+++
Sbjct: 620 IVRE 623
Score = 38.9 bits (89), Expect = 0.010
Identities = 56/284 (19%), Positives = 121/284 (42%), Gaps = 38/284 (13%)
Query: 75 EIKSQLKHEILELEKELCSL-RFAIQQEKKKRRNVEELHQKVREKLRIT--------EEQ 125
EI+ + KHE EL SL + Q +KK R +EE ++ L +T E
Sbjct: 666 EIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANED 725
Query: 126 YRIEADV-TKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLDT 184
+ D+ T +K + +++ K + + + + E +L +N ++ E+ +R
Sbjct: 726 FSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQ 785
Query: 185 DTIKNQNLEKKYLKDFEIVKRKH-----EDLQKALKRNGETLAKTIACYSGQLAALTDEN 239
+ + +KK L++ + + H +L K + E + + ++ L + +
Sbjct: 786 EKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQ----EIEKLEEIH 841
Query: 240 TTLRSKLEKQRE--------SRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGT 291
+++ EKQ E S ++ E ++ C+ + + +++ + + + AF G
Sbjct: 842 LQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGA 901
Query: 292 VDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALK 335
V + NS +S +L K++ K V+ T+L E ++
Sbjct: 902 V-------KANNS----MSKKLMKSDKKIAVISTKLFMEKERME 934
Score = 32.3 bits (72), Expect = 0.96
Identities = 84/398 (21%), Positives = 162/398 (40%), Gaps = 72/398 (18%)
Query: 45 KDNHCEQLRVKIRKLKNKASVLQKRISEKE----EIKSQLKHEILELEKELCSLRFAIQQ 100
K N E+ R++ ++L+N Q + KE EI + + LE KE + +
Sbjct: 538 KQNSLEE-RIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKE------DLLE 590
Query: 101 EKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSET 160
E+ K E + ++EKL E++ + + + L LKT + + + T
Sbjct: 591 ERNKELMKE--YNYLKEKLLQCEKEKAEREVIVREFQEELVD---HLKTFSISESPLEGT 645
Query: 161 DEKEDLLHENRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNGET 220
L+E + ++ ++ I+ + +++ K FE++ + + K+N E
Sbjct: 646 SHCHINLNETWTSKKKLFQVE-----IQPEEKHEEFRKLFELISLLNYTADQIRKKNREL 700
Query: 221 ------LAKTIACYSGQLAALTDENTTLRSKLE-------------KQRESRQRLETEMQ 261
K + L A +E+ + L KQ+ + E E
Sbjct: 701 EEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAV 760
Query: 262 SYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQE----------NLNSH-----V 306
S C +N A+ D++ H + L+ + +KC L++ NL +H V
Sbjct: 761 SSEC-VNLAK-DNEVLHQ----ELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMV 814
Query: 307 LILSLQLSKAESKSRVLKT-----ELHYTGEALKEKAL--VFEHVQSELKQKQSQMKDIE 359
+ LQ K+E R ++ E+H +A EK L + + + LK+K+ +KD+E
Sbjct: 815 ELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVE 874
Query: 360 KMY---KSGYNTMEKCIEK-QERFCQLKKQNMLLQQQL 393
+ K+ Y + +E+ +E F K N + ++L
Sbjct: 875 CKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKL 912
>gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 177 bits (450), Expect = 1e-44
Identities = 133/424 (31%), Positives = 231/424 (54%), Gaps = 29/424 (6%)
Query: 61 NKASVLQKRISEKEEIKSQ----LKHEILELEKELCSLRFAIQQEKKK--RRNVEELHQK 114
N +S++ + + I SQ E L +L S+R I + K K + ++ +Q+
Sbjct: 318 NLSSIVTLLLQQNIRISSQDMFGQTAEDYALCSDLRSIRQQILEHKNKMLKNHLRNDNQE 377
Query: 115 VREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSET-DEKEDLLHENRLM 173
++ + A +K A + + L+ N Q S++ +K+D ++ N ++
Sbjct: 378 TAAMKPANLKKRKERAKAEHNLKVASEEKQERLQRSENKQPQDSQSYGKKKDAMYGNFML 437
Query: 174 QDEIARLRLDTDTIKNQNL--EKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQ 231
+ +IA L+ + IKN +L EKKY+++ + + + + +K+++ N + + KT+A YS Q
Sbjct: 438 KKDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEKMITKTVARYSQQ 497
Query: 232 LAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGT 291
L L EN L S+LEK++ +++RLE E++S H L A ++++ ++D EL
Sbjct: 498 LNDLKAENARLNSELEKEKHNKERLEAEVESLHSSLATAINEYNEI-VERKDLELVLWRA 556
Query: 292 VDKCRHLQENLNSHVL-----ILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQS 346
D RH + N L +L+ Q+ KA K LK +L T +AL+EK L VQ
Sbjct: 557 DDVSRHEKMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRDALREKTLALGSVQL 616
Query: 347 ELKQKQSQMKDIEKMYKSGYNTMEKCIEKQ----ERFCQLKKQNMLLQQQLDDARNKADN 402
+L+Q Q ++K++++M+ +G + I KQ ER Q + +N+LL++QL+DAR + DN
Sbjct: 617 DLRQAQHRIKEMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLERQLEDARKEGDN 676
Query: 403 QEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREV 462
+E ++NI C ++N + + LLEE NK L+ E N+ KEK Q EKEKAEREV
Sbjct: 677 KE-IVINIHRDC---LENGKED------LLEERNKELMKEYNYLKEKLLQCEKEKAEREV 726
Query: 463 SIKK 466
+++
Sbjct: 727 IVRE 730
Score = 38.9 bits (89), Expect = 0.010
Identities = 56/284 (19%), Positives = 121/284 (42%), Gaps = 38/284 (13%)
Query: 75 EIKSQLKHEILELEKELCSL-RFAIQQEKKKRRNVEELHQKVREKLRIT--------EEQ 125
EI+ + KHE EL SL + Q +KK R +EE ++ L +T E
Sbjct: 773 EIQPEEKHEEFRKLFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANED 832
Query: 126 YRIEADV-TKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLDT 184
+ D+ T +K + +++ K + + + + E +L +N ++ E+ +R
Sbjct: 833 FSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQ 892
Query: 185 DTIKNQNLEKKYLKDFEIVKRKH-----EDLQKALKRNGETLAKTIACYSGQLAALTDEN 239
+ + +KK L++ + + H +L K + E + + ++ L + +
Sbjct: 893 EKCEKLEKDKKMLEEEVLNLKTHMEKDMVELGKLQEYKSELDERAVQ----EIEKLEEIH 948
Query: 240 TTLRSKLEKQRE--------SRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGT 291
+++ EKQ E S ++ E ++ C+ + + +++ + + + AF G
Sbjct: 949 LQKQAEYEKQLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEEVTTELEEFKEAFAGA 1008
Query: 292 VDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALK 335
V + NS +S +L K++ K V+ T+L + +K
Sbjct: 1009 V-------KANNS----MSKKLMKSDKKIAVISTKLFTEKQRMK 1041
Score = 32.3 bits (72), Expect = 0.96
Identities = 84/398 (21%), Positives = 162/398 (40%), Gaps = 72/398 (18%)
Query: 45 KDNHCEQLRVKIRKLKNKASVLQKRISEKE----EIKSQLKHEILELEKELCSLRFAIQQ 100
K N E+ R++ ++L+N Q + KE EI + + LE KE + +
Sbjct: 645 KQNSLEE-RIRQQELENLLLERQLEDARKEGDNKEIVINIHRDCLENGKE------DLLE 697
Query: 101 EKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSET 160
E+ K E + ++EKL E++ + + + L LKT + + + T
Sbjct: 698 ERNKELMKE--YNYLKEKLLQCEKEKAEREVIVREFQEELVD---HLKTFSISESPLEGT 752
Query: 161 DEKEDLLHENRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNGET 220
L+E + ++ ++ I+ + +++ K FE++ + + K+N E
Sbjct: 753 SHCHINLNETWTSKKKLFQVE-----IQPEEKHEEFRKLFELISLLNYTADQIRKKNREL 807
Query: 221 ------LAKTIACYSGQLAALTDENTTLRSKLE-------------KQRESRQRLETEMQ 261
K + L A +E+ + L KQ+ + E E
Sbjct: 808 EEEATGYKKCLEMTINMLNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFNDLVAEKEAV 867
Query: 262 SYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQE----------NLNSH-----V 306
S C +N A+ D++ H + L+ + +KC L++ NL +H V
Sbjct: 868 SSEC-VNLAK-DNEVLHQ----ELLSMRNVQEKCEKLEKDKKMLEEEVLNLKTHMEKDMV 921
Query: 307 LILSLQLSKAESKSRVLKT-----ELHYTGEALKEKAL--VFEHVQSELKQKQSQMKDIE 359
+ LQ K+E R ++ E+H +A EK L + + + LK+K+ +KD+E
Sbjct: 922 ELGKLQEYKSELDERAVQEIEKLEEIHLQKQAEYEKQLEQLNKDNTASLKKKELTLKDVE 981
Query: 360 KMY---KSGYNTMEKCIEK-QERFCQLKKQNMLLQQQL 393
+ K+ Y + +E+ +E F K N + ++L
Sbjct: 982 CKFSKMKTAYEEVTTELEEFKEAFAGAVKANNSMSKKL 1019
>gi|239754871 PREDICTED: similar to Coiled-coil domain-containing
protein 144C [Homo sapiens]
Length = 264
Score = 124 bits (311), Expect = 2e-28
Identities = 70/174 (40%), Positives = 113/174 (64%), Gaps = 14/174 (8%)
Query: 95 RFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNS 154
R ++QE++KR++ + L++K E+L+ EE+Y + ++ + +K LK+ +EL+T N
Sbjct: 91 RLTLKQEEEKRKDADMLYKKGSEELKRKEEEYGKDVEINQQLKRTLKTRAMELRTVRKNL 150
Query: 155 NQ-----------VSETDEKED-LLHENRLMQDEIARLRLDTDTIKNQN--LEKKYLKDF 200
+Q +S + +KE LLHEN ++Q+EIA LRL+ DTIK+QN EKKY +D
Sbjct: 151 DQTFGNLHSLRFEISLSHKKEKGLLHENSMLQEEIAMLRLELDTIKHQNEIKEKKYFEDI 210
Query: 201 EIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQ 254
E VK +H++L KA+ N E LAKT+ Y+GQL+ LT EN L S+L+ + +++
Sbjct: 211 ESVKEEHDNLLKAITLNEEALAKTVFQYNGQLSILTTENKMLSSELKNVKHNKE 264
Score = 32.7 bits (73), Expect = 0.74
Identities = 30/132 (22%), Positives = 63/132 (47%), Gaps = 11/132 (8%)
Query: 342 EHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLKKQ-NMLLQQQLDDARNKA 400
E+ + LKQ++ + KD + +YK G +++ E+ + ++ +Q L+ + + R
Sbjct: 88 EYHRLTLKQEEEKRKDADMLYKKGSEELKRKEEEYGKDVEINQQLKRTLKTRAMELRTVR 147
Query: 401 DNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAER 460
N ++ N+ + R + + +K + LL E N ML E+ + E + +
Sbjct: 148 KNLDQTFGNLHS---LRFE-ISLSHKKEKGLLHE-NSMLQEEI-----AMLRLELDTIKH 197
Query: 461 EVSIKKNKYFSN 472
+ IK+ KYF +
Sbjct: 198 QNEIKEKKYFED 209
>gi|239749410 PREDICTED: similar to Coiled-coil domain-containing
protein 144C [Homo sapiens]
Length = 264
Score = 124 bits (311), Expect = 2e-28
Identities = 70/174 (40%), Positives = 113/174 (64%), Gaps = 14/174 (8%)
Query: 95 RFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNS 154
R ++QE++KR++ + L++K E+L+ EE+Y + ++ + +K LK+ +EL+T N
Sbjct: 91 RLTLKQEEEKRKDADMLYKKGSEELKRKEEEYGKDVEINQQLKRTLKTRAMELRTVRKNL 150
Query: 155 NQ-----------VSETDEKED-LLHENRLMQDEIARLRLDTDTIKNQN--LEKKYLKDF 200
+Q +S + +KE LLHEN ++Q+EIA LRL+ DTIK+QN EKKY +D
Sbjct: 151 DQTFGNLHSLRFEISLSHKKEKGLLHENSMLQEEIAMLRLELDTIKHQNEIKEKKYFEDI 210
Query: 201 EIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQ 254
E VK +H++L KA+ N E LAKT+ Y+GQL+ LT EN L S+L+ + +++
Sbjct: 211 ESVKEEHDNLLKAITLNEEALAKTVFQYNGQLSILTTENKMLSSELKNVKHNKE 264
Score = 32.7 bits (73), Expect = 0.74
Identities = 30/132 (22%), Positives = 63/132 (47%), Gaps = 11/132 (8%)
Query: 342 EHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLKKQ-NMLLQQQLDDARNKA 400
E+ + LKQ++ + KD + +YK G +++ E+ + ++ +Q L+ + + R
Sbjct: 88 EYHRLTLKQEEEKRKDADMLYKKGSEELKRKEEEYGKDVEINQQLKRTLKTRAMELRTVR 147
Query: 401 DNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAER 460
N ++ N+ + R + + +K + LL E N ML E+ + E + +
Sbjct: 148 KNLDQTFGNLHS---LRFE-ISLSHKKEKGLLHE-NSMLQEEI-----AMLRLELDTIKH 197
Query: 461 EVSIKKNKYFSN 472
+ IK+ KYF +
Sbjct: 198 QNEIKEKKYFED 209
>gi|239743545 PREDICTED: hypothetical protein XP_002342885 [Homo
sapiens]
Length = 264
Score = 124 bits (311), Expect = 2e-28
Identities = 70/174 (40%), Positives = 113/174 (64%), Gaps = 14/174 (8%)
Query: 95 RFAIQQEKKKRRNVEELHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNS 154
R ++QE++KR++ + L++K E+L+ EE+Y + ++ + +K LK+ +EL+T N
Sbjct: 91 RLTLKQEEEKRKDADMLYKKGSEELKRKEEEYGKDVEINQQLKRTLKTRAMELRTVRKNL 150
Query: 155 NQ-----------VSETDEKED-LLHENRLMQDEIARLRLDTDTIKNQN--LEKKYLKDF 200
+Q +S + +KE LLHEN ++Q+EIA LRL+ DTIK+QN EKKY +D
Sbjct: 151 DQTFGNLHSLRFEISLSHKKEKGLLHENSMLQEEIAMLRLELDTIKHQNEIKEKKYFEDI 210
Query: 201 EIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQ 254
E VK +H++L KA+ N E LAKT+ Y+GQL+ LT EN L S+L+ + +++
Sbjct: 211 ESVKEEHDNLLKAITLNEEALAKTVFQYNGQLSILTTENKMLSSELKNVKHNKE 264
Score = 32.7 bits (73), Expect = 0.74
Identities = 30/132 (22%), Positives = 63/132 (47%), Gaps = 11/132 (8%)
Query: 342 EHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLKKQ-NMLLQQQLDDARNKA 400
E+ + LKQ++ + KD + +YK G +++ E+ + ++ +Q L+ + + R
Sbjct: 88 EYHRLTLKQEEEKRKDADMLYKKGSEELKRKEEEYGKDVEINQQLKRTLKTRAMELRTVR 147
Query: 401 DNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAER 460
N ++ N+ + R + + +K + LL E N ML E+ + E + +
Sbjct: 148 KNLDQTFGNLHS---LRFE-ISLSHKKEKGLLHE-NSMLQEEI-----AMLRLELDTIKH 197
Query: 461 EVSIKKNKYFSN 472
+ IK+ KYF +
Sbjct: 198 QNEIKEKKYFED 209
>gi|169168964 PREDICTED: hypothetical protein LOC100131031 [Homo
sapiens]
Length = 252
Score = 108 bits (270), Expect = 1e-23
Identities = 63/138 (45%), Positives = 85/138 (61%), Gaps = 8/138 (5%)
Query: 156 QVSETDEKEDLLHENRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIVKRKHEDLQKALK 215
QV+ +E+E L EN+ Q E AR K K KD EIVK ++DLQ+ +K
Sbjct: 116 QVTSEEEQEKLESENKQPQVEEAR--------KKHERTSKGKKDIEIVKEMNDDLQETIK 167
Query: 216 RNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHD 275
NG+TL KT++ Y QL L ENT L+SKLEK+ ++++RLE E++S+H RL AA + D
Sbjct: 168 LNGKTLTKTVSQYGQQLNDLKTENTMLKSKLEKENQNKERLEAEVESFHARLAAAISECD 227
Query: 276 QSHSSKRDQELAFQGTVD 293
QS +KRD ELA Q D
Sbjct: 228 QSVKTKRDLELALQRAQD 245
Score = 32.0 bits (71), Expect = 1.3
Identities = 36/201 (17%), Positives = 85/201 (42%), Gaps = 36/201 (17%)
Query: 168 HENRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIAC 227
+EN L+ +++ ++T+ + KD E++ K L I C
Sbjct: 42 NENTLLAEKLPSHHVNTEVLN---------KDTEVLN----------KDANTPLLLAIVC 82
Query: 228 YSGQLAALTDENTTLRSKLEKQRESRQRLETEMQ-------------SYHCRLNAARCDH 274
+ Q + +++ ++ +E++ E + E E+Q + ++ AR H
Sbjct: 83 KTQQKPTMEMKDSVVKKAIERKNEQTSKAEQEVQVTSEEEQEKLESENKQPQVEEARKKH 142
Query: 275 DQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEAL 334
+++ K+D E+ + D LQE + + L+ +S+ + LKTE L
Sbjct: 143 ERTSKGKKDIEIVKEMNDD----LQETIKLNGKTLTKTVSQYGQQLNDLKTENTMLKSKL 198
Query: 335 KEKALVFEHVQSELKQKQSQM 355
+++ E +++E++ +++
Sbjct: 199 EKENQNKERLEAEVESFHARL 219
>gi|169168628 PREDICTED: hypothetical protein LOC100131031 [Homo
sapiens]
Length = 252
Score = 108 bits (270), Expect = 1e-23
Identities = 63/138 (45%), Positives = 85/138 (61%), Gaps = 8/138 (5%)
Query: 156 QVSETDEKEDLLHENRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIVKRKHEDLQKALK 215
QV+ +E+E L EN+ Q E AR K K KD EIVK ++DLQ+ +K
Sbjct: 116 QVTSEEEQEKLESENKQPQVEEAR--------KKHERTSKGKKDIEIVKEMNDDLQETIK 167
Query: 216 RNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHD 275
NG+TL KT++ Y QL L ENT L+SKLEK+ ++++RLE E++S+H RL AA + D
Sbjct: 168 LNGKTLTKTVSQYGQQLNDLKTENTMLKSKLEKENQNKERLEAEVESFHARLAAAISECD 227
Query: 276 QSHSSKRDQELAFQGTVD 293
QS +KRD ELA Q D
Sbjct: 228 QSVKTKRDLELALQRAQD 245
Score = 32.0 bits (71), Expect = 1.3
Identities = 36/201 (17%), Positives = 85/201 (42%), Gaps = 36/201 (17%)
Query: 168 HENRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIAC 227
+EN L+ +++ ++T+ + KD E++ K L I C
Sbjct: 42 NENTLLAEKLPSHHVNTEVLN---------KDTEVLN----------KDANTPLLLAIVC 82
Query: 228 YSGQLAALTDENTTLRSKLEKQRESRQRLETEMQ-------------SYHCRLNAARCDH 274
+ Q + +++ ++ +E++ E + E E+Q + ++ AR H
Sbjct: 83 KTQQKPTMEMKDSVVKKAIERKNEQTSKAEQEVQVTSEEEQEKLESENKQPQVEEARKKH 142
Query: 275 DQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEAL 334
+++ K+D E+ + D LQE + + L+ +S+ + LKTE L
Sbjct: 143 ERTSKGKKDIEIVKEMNDD----LQETIKLNGKTLTKTVSQYGQQLNDLKTENTMLKSKL 198
Query: 335 KEKALVFEHVQSELKQKQSQM 355
+++ E +++E++ +++
Sbjct: 199 EKENQNKERLEAEVESFHARL 219
>gi|169169551 PREDICTED: hypothetical protein LOC100131031 [Homo
sapiens]
Length = 252
Score = 108 bits (270), Expect = 1e-23
Identities = 63/138 (45%), Positives = 85/138 (61%), Gaps = 8/138 (5%)
Query: 156 QVSETDEKEDLLHENRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIVKRKHEDLQKALK 215
QV+ +E+E L EN+ Q E AR K K KD EIVK ++DLQ+ +K
Sbjct: 116 QVTSEEEQEKLESENKQPQVEEAR--------KKHERTSKGKKDIEIVKEMNDDLQETIK 167
Query: 216 RNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHD 275
NG+TL KT++ Y QL L ENT L+SKLEK+ ++++RLE E++S+H RL AA + D
Sbjct: 168 LNGKTLTKTVSQYGQQLNDLKTENTMLKSKLEKENQNKERLEAEVESFHARLAAAISECD 227
Query: 276 QSHSSKRDQELAFQGTVD 293
QS +KRD ELA Q D
Sbjct: 228 QSVKTKRDLELALQRAQD 245
Score = 32.0 bits (71), Expect = 1.3
Identities = 36/201 (17%), Positives = 85/201 (42%), Gaps = 36/201 (17%)
Query: 168 HENRLMQDEIARLRLDTDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIAC 227
+EN L+ +++ ++T+ + KD E++ K L I C
Sbjct: 42 NENTLLAEKLPSHHVNTEVLN---------KDTEVLN----------KDANTPLLLAIVC 82
Query: 228 YSGQLAALTDENTTLRSKLEKQRESRQRLETEMQ-------------SYHCRLNAARCDH 274
+ Q + +++ ++ +E++ E + E E+Q + ++ AR H
Sbjct: 83 KTQQKPTMEMKDSVVKKAIERKNEQTSKAEQEVQVTSEEEQEKLESENKQPQVEEARKKH 142
Query: 275 DQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEAL 334
+++ K+D E+ + D LQE + + L+ +S+ + LKTE L
Sbjct: 143 ERTSKGKKDIEIVKEMNDD----LQETIKLNGKTLTKTVSQYGQQLNDLKTENTMLKSKL 198
Query: 335 KEKALVFEHVQSELKQKQSQM 355
+++ E +++E++ +++
Sbjct: 199 EKENQNKERLEAEVESFHARL 219
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.129 0.353
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,322,579
Number of Sequences: 37866
Number of extensions: 735866
Number of successful extensions: 11167
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 265
Number of HSP's successfully gapped in prelim test: 943
Number of HSP's that attempted gapping in prelim test: 5328
Number of HSP's gapped (non-prelim): 4053
length of query: 475
length of database: 18,247,518
effective HSP length: 106
effective length of query: 369
effective length of database: 14,233,722
effective search space: 5252243418
effective search space used: 5252243418
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.