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Search of human proteins with 16507950
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16507950 tektin 2 [Homo sapiens]
(430 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16507950 tektin 2 [Homo sapiens] 845 0.0
gi|16753231 tektin 1 [Homo sapiens] 211 1e-54
gi|13994250 tektin 3 [Homo sapiens] 191 8e-49
gi|21389613 tektin 4 [Homo sapiens] 189 3e-48
gi|21389569 tektin 5 [Homo sapiens] 164 2e-40
gi|239747088 PREDICTED: MAFF interacting protein [Homo sapiens] 155 5e-38
gi|239747014 PREDICTED: similar to tektin 4 [Homo sapiens] 82 7e-16
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 67 4e-11
gi|31982906 cingulin-like 1 [Homo sapiens] 60 5e-09
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 56 6e-08
gi|210032790 hypothetical protein LOC27146 [Homo sapiens] 55 9e-08
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap... 55 2e-07
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap... 55 2e-07
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap... 55 2e-07
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 54 2e-07
gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 54 3e-07
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 54 4e-07
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 53 5e-07
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 52 1e-06
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 52 1e-06
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 52 1e-06
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 52 1e-06
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 52 1e-06
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 52 1e-06
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 52 1e-06
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 52 1e-06
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 52 1e-06
gi|156104908 myosin heavy chain 6 [Homo sapiens] 51 2e-06
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 50 5e-06
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 50 5e-06
>gi|16507950 tektin 2 [Homo sapiens]
Length = 430
Score = 845 bits (2183), Expect = 0.0
Identities = 430/430 (100%), Positives = 430/430 (100%)
Query: 1 MATLSVKPSRRFQLPDWHTNSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDN 60
MATLSVKPSRRFQLPDWHTNSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDN
Sbjct: 1 MATLSVKPSRRFQLPDWHTNSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDN 60
Query: 61 RTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLR 120
RTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLR
Sbjct: 61 RTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLR 120
Query: 121 ESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKM 180
ESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKM
Sbjct: 121 ESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKM 180
Query: 181 ETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELR 240
ETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELR
Sbjct: 181 ETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELR 240
Query: 241 EATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHL 300
EATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHL
Sbjct: 241 EATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHL 300
Query: 301 EEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQ 360
EEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQ
Sbjct: 301 EEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQ 360
Query: 361 DALDALCKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAERFVPEVDTFTRTTNSTLS 420
DALDALCKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAERFVPEVDTFTRTTNSTLS
Sbjct: 361 DALDALCKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAERFVPEVDTFTRTTNSTLS 420
Query: 421 PLKSCQLELA 430
PLKSCQLELA
Sbjct: 421 PLKSCQLELA 430
>gi|16753231 tektin 1 [Homo sapiens]
Length = 418
Score = 211 bits (536), Expect = 1e-54
Identities = 131/393 (33%), Positives = 202/393 (51%), Gaps = 1/393 (0%)
Query: 6 VKPSRRFQLPDWHTNSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLV 65
++P +F +WH + A QR S ++ E++ L +E T + D +L
Sbjct: 5 LQPPPKFLPSEWHIANKNQYHRADAQRSRSERLVAESQRLVDEIEKTTRKSQSDVNKKLE 64
Query: 66 ERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRD 125
+R++ V WK+ LD L L D L K E+ L+ PL + CL RE R
Sbjct: 65 QRLEEVQFWKKELDDKLEQLVNVTDDLLIYKIRLEKALETLKEPLHITETCLAYREKRIG 124
Query: 126 IDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEI 185
ID+V D VE EL KE E+I+ L + + +A EQ+ + + + L D + K L I
Sbjct: 125 IDLVHDTVEHELIKEAEIIQGIMALLTRTLEEASEQIRMNRSAKYNLEKDLKDKFVALTI 184
Query: 186 DRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATAL 245
D C SLN SPNI + R+ S +L+ W DFS N ++A+ + + L+
Sbjct: 185 DDICFSLNNNSPNIRYSENAVRIEPNSVSLEDWLDFSSTNVEKADKQRNNSLMLKALVDR 244
Query: 246 TIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLR 305
+++T N+L Q + AF+ L++ + +L +EEIA +++I LE+ +
Sbjct: 245 ILSQTANDLRKQCDVVDTAFKNGLKDTKDARDKLADHLAKVMEEIASQEKNITALEKAIL 304
Query: 306 TKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDA 365
+ K++HTRLE RT+RPNVELCRD AQY L EV ++ +A LK+ LAQAQ L
Sbjct: 305 DQEGPAKVAHTRLETRTHRPNVELCRDVAQYRLMKEVQEITHNVARLKETLAQAQAELKG 364
Query: 366 LCKHLARLQADIACKANSMLLD-TKCMDTRRKL 397
L + LQ +I K N++ +D CM R+ +
Sbjct: 365 LHRRQLALQEEIQVKENTIYIDEVLCMQMRKSI 397
>gi|13994250 tektin 3 [Homo sapiens]
Length = 490
Score = 191 bits (486), Expect = 8e-49
Identities = 121/386 (31%), Positives = 195/386 (50%), Gaps = 1/386 (0%)
Query: 11 RFQLPDWHTNSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDT 70
R+ DW+ ++ + R S ++R + L + QT + D L ER++
Sbjct: 93 RYTPDDWYRSNLTNYQESNTSRHNSEKLRVDTSRLIQDKYQQTRKTQADTTQNLGERVND 152
Query: 71 VNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVK 130
+ WK + L ++ E +ALT +K+ E+ L PL VA ECL RE R ID+V
Sbjct: 153 IGFWKSEIIHELDEMIGETNALTDVKKRLERALMETEAPLQVARECLFHREKRMGIDLVH 212
Query: 131 DPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCL 190
D VE +L EV+ I ++ ++ + +A QL + Q +L D K ID C
Sbjct: 213 DEVEAQLLTEVDTILCCQERMKLHLDKAIAQLAANRASQHELEKDLSDKQTAYRIDDKCH 272
Query: 191 SLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAET 250
L S + RV + + W F+ N R+++E A+ +LR+ + T
Sbjct: 273 HLRNTSDGVGYFRGVERVDATVSVPESWAKFTDDNILRSQSERAASAKLRDDIENLLVVT 332
Query: 251 NNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLS 310
NE+ Q +F R+ E ++++ TL+EI + + I +++ ++ K
Sbjct: 333 ANEMWNQFNKVNLSFTNRIAETADAKNKIQTHLAKTLQEIFQTEMTIESIKKAIKDKTAF 392
Query: 311 LKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHL 370
LK++ TRL+ RT RPN+ELCRD AQ L +EVH+++ TI L+Q+L A+D L +L
Sbjct: 393 LKVAQTRLDERTRRPNIELCRDMAQLRLVNEVHEVDDTIQTLQQRLRDAEDTLQSLVHIK 452
Query: 371 ARLQADIACKANSMLLD-TKCMDTRR 395
A L+ D+A KANS+ +D KCM R+
Sbjct: 453 ATLEYDLAVKANSLYIDQEKCMSMRK 478
>gi|21389613 tektin 4 [Homo sapiens]
Length = 435
Score = 189 bits (481), Expect = 3e-48
Identities = 123/397 (30%), Positives = 201/397 (50%), Gaps = 2/397 (0%)
Query: 1 MATLSVKPSRRFQLPDWHTNSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDN 60
+AT S + S+ + L +W N Y A RD S + R E++ L ET + D+
Sbjct: 29 LATASFRTSK-YLLEEWFQNCYARYHQAFADRDQSERQRHESQQLATETQALAQRTQQDS 87
Query: 61 RTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLR 120
+ ER+ + WK L + + L AE + L K+ E+ L A +P + + L R
Sbjct: 88 TRTVGERLQDTHSWKSELQREMEALAAETNLLLAQKQRLERALDATEVPFSITTDNLQCR 147
Query: 121 ESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKM 180
E R ++V+D VE EL KE E+I ++ L++ + QA Q+ L +E ++ D KM
Sbjct: 148 ERREHPNLVRDHVETELLKEAELIRNIQELLKRTIMQAVSQIRLNREHKETCEMDWSDKM 207
Query: 181 ETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELR 240
E ID C + +S + T + ++T + F++ N RA+ E A+ LR
Sbjct: 208 EAYNIDETCGRHHSQSTEVQAHPYSTTFQESASTPETRAKFTQDNLCRAQRERLASANLR 267
Query: 241 EATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHL 300
+ +T+ +L Q A AF +R E+E +L TL EI + + ++ L
Sbjct: 268 VLVDCILRDTSEDLRLQCDAVNLAFGRRCEELEDARYKLHHHLHKTLREITDQEHNVAAL 327
Query: 301 EEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQ 360
++ ++ K L ++ TRL R++RPN+ELCRD AQ+ L EV +L ++ AL++KL +A+
Sbjct: 328 KQAIKDKEAPLHVAQTRLYLRSHRPNMELCRDAAQFRLLSEVEELNMSLTALREKLLEAE 387
Query: 361 DALDALCKHLARLQADIACKANSMLLD-TKCMDTRRK 396
+L L L+ DIA NS+ +D KCM R +
Sbjct: 388 QSLRNLEDIHMSLEKDIAAMTNSLFIDRQKCMAHRTR 424
>gi|21389569 tektin 5 [Homo sapiens]
Length = 485
Score = 164 bits (414), Expect = 2e-40
Identities = 114/386 (29%), Positives = 184/386 (47%), Gaps = 1/386 (0%)
Query: 11 RFQLPDWHTNSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDT 70
R+ DW ++ L A+ R + ++ ++ L + + T + L +R+
Sbjct: 88 RYSPHDWDQSNQLQVRGAEASRLWASRLTDDSMRLLQDKDQLTHQMQEGTCRNLGQRLSD 147
Query: 71 VNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVK 130
+ WK L L L E L +K E N PL VA+ECL RE R ID+V
Sbjct: 148 IGFWKSELSYELDRLLTENQNLETVKRRLECAANEVNCPLQVALECLYHREKRIGIDLVH 207
Query: 131 DPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCL 190
D VE L +EV++++ ++ +++ + Q+ ++ Q L D K ID C
Sbjct: 208 DNVEKNLIREVDLLKCCQEQMRKLAQRIDIQMRDNRDAQHVLERDLEDKSSAQCIDEKCF 267
Query: 191 SLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAET 250
+L S IS ++ + + W FS N ++ + +LRE
Sbjct: 268 NLRNTSDCISFFHGMEKIDGTISVPETWAKFSNDNIKHSQNMRANSIQLREEAEHLFETL 327
Query: 251 NNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLS 310
++++ Q T AF R+ E+ V ++L+ Q TL+EI + + I LE + K
Sbjct: 328 SDQMWRQFTDTNLAFNARISEVTDVKNKLQTQLAKTLQEIFQAENTIMLLERSIMAKEGP 387
Query: 311 LKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHL 370
LK++ TRLE RT RPN+ELCRD Q L +EV ++ T+ LK +L + QD L L
Sbjct: 388 LKVAQTRLECRTRRPNMELCRDIPQLKLVNEVFTIDDTLQTLKLRLRETQDTLQLLVMTK 447
Query: 371 ARLQADIACKANSMLLD-TKCMDTRR 395
RL+ ++A KAN++ +D KCM R+
Sbjct: 448 CRLEHELAIKANTLCIDKEKCMGMRK 473
>gi|239747088 PREDICTED: MAFF interacting protein [Homo sapiens]
Length = 445
Score = 155 bits (393), Expect = 5e-38
Identities = 106/371 (28%), Positives = 180/371 (48%), Gaps = 12/371 (3%)
Query: 29 QLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDAE 88
+LQ S Q+ E + L T + D+ R+ ER+ N WK L + + L AE
Sbjct: 69 ELQGHESQQLAAETQALAQPT-------QQDSTCRVGERLQDTNSWKSELQREVEALAAE 121
Query: 89 IDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVIEATK 148
D L K+ E+ L A +P + + + + + ++++D VE EL KE E+I +
Sbjct: 122 TDLLLAQKQRLERALDAMEVPFSITTDNMQCSQRHQHTNLLRDHVETELLKEAELIRNIQ 181
Query: 149 KALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPT-- 206
+ L++ + QA Q+ L E + D K+E +D+ C + +S + T
Sbjct: 182 ELLKRAIMQAVSQIXLNXEHMEICEMDWSDKVEAYNLDKTCGRHHSQSTEVQAHPHSTTF 241
Query: 207 --RVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFA 264
R P ++T + F++ N A+ E + L + +T+ +L Q A A
Sbjct: 242 QERGPRSASTPETRTKFTQDNLCHAQRERLDSANLWVLVDCILRDTSEDLGLQCDAVNLA 301
Query: 265 FRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYR 324
F +R E+E +L+ L EI + + ++ L+E ++ K L ++ TRL ++R
Sbjct: 302 FGRRCEELEDARHKLQHHLHKMLREITDQEHNVVALKEAIKDKEEPLHIAQTRLXLLSHR 361
Query: 325 PNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKANSM 384
PN++LCRD AQ+ L EV +L +I AL++KL QA+ +L L L+ D+ NS+
Sbjct: 362 PNMQLCRDAAQFRLVSEVEELYKSITALREKLLQAEQSLRNLKDIHMSLEKDVTAMTNSV 421
Query: 385 LLD-TKCMDTR 394
+D KCM R
Sbjct: 422 FIDRQKCMAHR 432
>gi|239747014 PREDICTED: similar to tektin 4 [Homo sapiens]
Length = 507
Score = 82.4 bits (202), Expect = 7e-16
Identities = 106/470 (22%), Positives = 178/470 (37%), Gaps = 124/470 (26%)
Query: 29 QLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDAE 88
+LQ S Q+ E + L T + D++ R+ ER+ ++ W L + L AE
Sbjct: 39 ELQGHKSQQLAAEIQALAQPT-------QQDSKCRVGERLQDMHSWNSELQGEVEALAAE 91
Query: 89 IDALTQMKESAE--------------------QNLQAKNL----------------PLDV 112
D L K+ E Q Q NL P
Sbjct: 92 TDLLLAQKQRLEHALDAMEVPFSIATDNMQCNQRHQHANLVRDHVETELLKAYPPAPSQC 151
Query: 113 AIECLTLRE---SRRDIDVVKDP--VEDELH--------------KEVEVIEATKKALQQ 153
C + R+ S + + V + V++E + +E E+I ++ L++
Sbjct: 152 LKNCCSSRKPSASNKGVCEVMETLTVQEEANPGTEGCRTRALAHKEEAELIRNIQELLKR 211
Query: 154 KVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGST 213
+ QA Q+ L +E + D K+E +D C +S P ++
Sbjct: 212 VIVQAVSQIRLNREHMEICEMDWSDKVEAYNLDETCGRHRSQSTE----------PRSAS 261
Query: 214 TLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLREME 273
T + F++ N RA+ E + L + +T+ +L Q A AF +R E+E
Sbjct: 262 TPETRTKFTQDNLCRAQRERLDSANLWVLVDCILRDTSEDLGLQCDAVNLAFGRRCEELE 321
Query: 274 KVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQ 333
+L+ + L EI + + ++ L+E ++ K L ++ TRL ++RPN+ELCRD
Sbjct: 322 DARHKLQHHLQKMLREITDQEHNMVALKEAIKDKEAPLHIAQTRLYLLSHRPNMELCRDA 381
Query: 334 AQY-----------------------GLT----------------------------DEV 342
AQ+ GLT E+
Sbjct: 382 AQFRYRHDTGQVMGRGPPSARDLCPRGLTPPSATSSSQEEAPSDKPQLTPPNTPKLVSEL 441
Query: 343 HQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKANSMLLDTK-CM 391
+L +I AL +KL QA+ +L L L+ D+ NS+ LD + CM
Sbjct: 442 EELYKSITALWEKLLQAEQSLHNLEDIHMSLEKDVTAMTNSLFLDRQNCM 491
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 66.6 bits (161), Expect = 4e-11
Identities = 70/328 (21%), Positives = 144/328 (43%), Gaps = 25/328 (7%)
Query: 46 RNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQA 105
+NE +++ + ++RL ++R E + ++ L A TQ E ++ L+
Sbjct: 1263 KNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE 1322
Query: 106 KNLPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKV-------SQA 158
+N + L + SR D D++++ E+E + E+ A KA + + A
Sbjct: 1323 ENKAKNALAHAL--QSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDA 1380
Query: 159 FEQLCLLQEVQQQLNSDHRGKMETLE-IDRGCLSLNLRSPNISLKVDPTRVP-DGSTTLQ 216
++ L+E +++L + E +E ++ C SL + +V+ V + + +L
Sbjct: 1381 IQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLA 1440
Query: 217 QWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVY 276
D + N D+ AE K E +A + + L + + A+ + L ++E V
Sbjct: 1441 AALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETV- 1499
Query: 277 SELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQY 336
K + KN +EIA+L E I + + +L +R + + +++L ++A+
Sbjct: 1500 ---KRENKNLEQEIADLTEQIAENGKTIH------ELEKSRKQIELEKADIQLALEEAEA 1550
Query: 337 GLTDEVHQLEATIAALKQKLAQAQDALD 364
L E EA I ++ +L Q + +D
Sbjct: 1551 ALEHE----EAKILRIQLELTQVKSEID 1574
Score = 47.8 bits (112), Expect = 2e-05
Identities = 85/393 (21%), Positives = 169/393 (43%), Gaps = 61/393 (15%)
Query: 61 RTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLR 120
R L E++ T+ + K L + AE + L +E +Q ++AK L+ I+ +T R
Sbjct: 871 RKELEEKLVTLVQEKNDLQ---LQVQAESENLLDAEERCDQLIKAK-FQLEAKIKEVTER 926
Query: 121 -----ESRRDIDVVKDPVEDE---LHKEVEVIEAT-------KKALQQKVSQAFEQLCLL 165
E ++ K +EDE L K+++ +E T K A + KV E+L L
Sbjct: 927 AEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGL 986
Query: 166 QEV-------QQQLNSDHRGKMETLEIDRGCL-SLNLRSPNISLKVDPTRVPDGSTTLQQ 217
E ++ L H+ ++ L+ + + SLN + +V+ D ++L+Q
Sbjct: 987 DETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVE-----DLESSLEQ 1041
Query: 218 WDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYS 277
+ R + +R + +++ +L + + L + +L+ +RL++ + Y
Sbjct: 1042 -EKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLD-----------ERLKKKDFEYC 1089
Query: 278 EL--KWQEKNTL-----EEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELC 330
+L K +++ TL ++I ELQ I LEE++ + + + T + Y +E
Sbjct: 1090 QLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERAT--RAKTEKQRSDYARELEEL 1147
Query: 331 RDQAQY--GLTDEVHQL----EATIAALKQKLAQAQDALDALCKHLARLQADIACKANSM 384
++ + G+T +L EA L++ L +A +A+ L + AD +
Sbjct: 1148 SERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQ 1207
Query: 385 LLDTKCMDTRRKLTVPAERFVPEVDTFTRTTNS 417
+ ++KL F E+D + + S
Sbjct: 1208 I--DNLQRVKQKLEKEKSEFKLEIDDLSSSMES 1238
Score = 45.1 bits (105), Expect = 1e-04
Identities = 69/340 (20%), Positives = 138/340 (40%), Gaps = 40/340 (11%)
Query: 41 EARVLRNETNNQTIWDEH-DNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESA 99
E L++E + +H D+ L E+ID + R K+ L+K ++ EID L+ ES
Sbjct: 1180 EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESV 1239
Query: 100 EQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAF 159
++ ++ C TL + + +E+ + + + K LQ + +
Sbjct: 1240 SKS------KANLEKICRTLEDQLSE----ARGKNEEIQRSLSELTTQKSRLQTEAGELS 1289
Query: 160 EQLCLLQEVQQQLN-SDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQW 218
QL + + QL+ S +T E+ R N ++ + +R D +Q+
Sbjct: 1290 RQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSR-HDCDLLREQY 1348
Query: 219 DDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSE 278
E E + EL+ A +++ N+E+ R E +R E+E+ +
Sbjct: 1349 -----------EEEQEGKAELQRA----LSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1393
Query: 279 LKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGL 338
L + +++ E++ E + K SL+ + RL+ V++ R +
Sbjct: 1394 LAQRLQDSEEQV-----------EAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAA 1442
Query: 339 TDEVHQ-LEATIAALKQKLAQAQDALDALCKHLARLQADI 377
D+ + + +A K K ++Q L+A K L ++
Sbjct: 1443 LDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTEL 1482
Score = 42.0 bits (97), Expect = 0.001
Identities = 68/338 (20%), Positives = 139/338 (41%), Gaps = 34/338 (10%)
Query: 64 LVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESR 123
L E I+ + +K +D E++ L++ E A + + + L+ E L+ R
Sbjct: 1119 LEEEIEAERATRAKTEKQRSDYARELEELSERLEEAG-GVTSTQIELNKKREAEFLK-LR 1176
Query: 124 RDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKME-T 182
RD++ E L E ++ A +K V++ EQ+ LQ V+Q+L + K E
Sbjct: 1177 RDLE------EATLQHEA-MVAALRKKHADSVAELGEQIDNLQRVKQKLEKE---KSEFK 1226
Query: 183 LEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREA 242
LEID +L S S+ + TL+ +R + + + T +
Sbjct: 1227 LEID------DLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSR 1280
Query: 243 TALTIAETNNELE------AQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQED 296
E + +LE +Q ++ AF ++ E+++ E E +A +
Sbjct: 1281 LQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE----ENKAKNALAHALQS 1336
Query: 297 IRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGL-----TDEVHQLEATIAA 351
RH + LR + + L+ + N E+ + + +Y T+E+ + + +A
Sbjct: 1337 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1396
Query: 352 LKQKLAQAQDALDALCKHLARLQADIACKANSMLLDTK 389
Q + +A++A C L + + + + +++D +
Sbjct: 1397 RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVE 1434
Score = 40.4 bits (93), Expect = 0.003
Identities = 66/318 (20%), Positives = 137/318 (43%), Gaps = 56/318 (17%)
Query: 66 ERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRD 125
++++++N+ K L++ + DL++ ++ +++ E+N R+ D
Sbjct: 1016 DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERN----------------KRKLEGD 1059
Query: 126 IDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQ---EVQQQLNSDHRGKMET 182
+ + ++ + D +E K+ L +++ + + C LQ E +Q L + K++
Sbjct: 1060 LKLAQESILD--------LENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKE 1111
Query: 183 LEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREA 242
L+ R + +++ R T Q+ D++R ++ +E L EA
Sbjct: 1112 LQ---------ARIEELEEEIEAERATRAKTEKQR-SDYARELEELSE-------RLEEA 1154
Query: 243 TALTIAETNNELEAQRVATEFAFRKRLREM----EKVYSELKWQEKNTLEEIAELQEDIR 298
+T T EL +R A R+ L E E + + L+ K + +AEL E I
Sbjct: 1155 GGVT--STQIELNKKREAEFLKLRRDLEEATLQHEAMVAALR---KKHADSVAELGEQID 1209
Query: 299 HLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQ 358
+L+ ++ KL K S +LE ++E +++ L LE ++ + K +
Sbjct: 1210 NLQR-VKQKLEKEK-SEFKLEIDDLSSSMESV-SKSKANLEKICRTLEDQLSEARGKNEE 1266
Query: 359 AQDALDALCKHLARLQAD 376
Q +L L +RLQ +
Sbjct: 1267 IQRSLSELTTQKSRLQTE 1284
Score = 30.4 bits (67), Expect = 3.2
Identities = 70/349 (20%), Positives = 137/349 (39%), Gaps = 57/349 (16%)
Query: 65 VERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRR 124
+++++TV R + L++ + DL +I K E K + L+ A L L E+
Sbjct: 1493 LDQLETVKRENKNLEQEIADLTEQI--AENGKTIHELEKSRKQIELEKADIQLALEEAEA 1550
Query: 125 DIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLE 184
++ H+E +++ + Q K S+ ++ E +QL +++ +ET++
Sbjct: 1551 ALE----------HEEAKILRIQLELTQVK-SEIDRKIAEKDEEIEQLKRNYQRTVETMQ 1599
Query: 185 IDRGCLSLNLRSPNISLKVDPTRVPD--------------GSTTLQQWDDFSRFNKD--- 227
L +RS N ++++ D + TL+ KD
Sbjct: 1600 ---SALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQL 1656
Query: 228 ------RAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKW 281
R + ++K + E A + EL A TE A ++L E E + S +
Sbjct: 1657 HLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERA--RKLAEQELLDSNERV 1714
Query: 282 Q------------EKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVEL 329
Q +K ++ +LQ ++ D R K + T +A ++
Sbjct: 1715 QLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAIT--DAAMMAEELKK 1772
Query: 330 CRDQAQYGLTDEVHQLEATIAALKQKLAQAQD-ALDALCKHLARLQADI 377
+D + + L LE T+ L+ +L +A+ AL K + +L+ I
Sbjct: 1773 EQDTSAH-LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRI 1820
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 59.7 bits (143), Expect = 5e-09
Identities = 79/363 (21%), Positives = 163/363 (44%), Gaps = 43/363 (11%)
Query: 24 LSTNAQLQRDASHQIRQEA------RVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEM 77
LS Q Q+ S ++++E+ R L+NE N+ W H +T +E++ KEM
Sbjct: 908 LSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENER-W--HLGKT--IEKLQ-----KEM 957
Query: 78 LDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDEL 137
D + ++ Q+ E E+N + + + ++ TL + + +K +
Sbjct: 958 ADIVEASRTSTLELQNQLDEYKEKN-RRELAEMQRQLKEKTLEAEKSRLTAMK------M 1010
Query: 138 HKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
E+ ++E + Q+ +A + LL++ + L + K L+ DR L +
Sbjct: 1011 QDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSH-LKDDRSRLVKQMEDK 1069
Query: 198 NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEM---KAATELREATALTIAETNNEL 254
L+++ + S L + SR ++ E+ +AA + E +++ N +L
Sbjct: 1070 VSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDL 1129
Query: 255 EAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLS 314
+++ + E ++R +E V E + IAEL++ + E D +L+LS
Sbjct: 1130 KSRIIHLEGSYRSS-KEGLVVQMEAR---------IAELEDRLESEERDRA----NLQLS 1175
Query: 315 HTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
+ RLE + +++ D LTD+ QL + A+K+++ +A++ +D L +LQ
Sbjct: 1176 NRRLERKVKELVMQV--DDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQ 1233
Query: 375 ADI 377
++
Sbjct: 1234 REL 1236
Score = 45.1 bits (105), Expect = 1e-04
Identities = 48/181 (26%), Positives = 81/181 (44%), Gaps = 23/181 (12%)
Query: 13 QLPDWHTNSYLLSTNAQLQRDASHQIRQEA---RVLRNETNNQTIWDEHDNRTRLVERID 69
+L + NS LLS R+ Q+R E R R + I E N+ I
Sbjct: 1076 ELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIH 1135
Query: 70 TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQ---NLQAKN---------LPLDVAIECL 117
++ + + ++A I L ES E+ NLQ N L + V E L
Sbjct: 1136 LEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHL 1195
Query: 118 TLRESRRDIDV----VKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLN 173
+L + + + + +K VE E +E++ +E++KK LQ+++ EQ+ + + +Q QLN
Sbjct: 1196 SLTDQKDQLSLRLKAMKRQVE-EAEEEIDRLESSKKKLQRELE---EQMDMNEHLQGQLN 1251
Query: 174 S 174
S
Sbjct: 1252 S 1252
Score = 43.9 bits (102), Expect = 3e-04
Identities = 65/319 (20%), Positives = 133/319 (41%), Gaps = 50/319 (15%)
Query: 43 RVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQN 102
+V N T Q + + + +E + V +E + DL D L++M + +
Sbjct: 661 KVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQ---DQLSEMHDELDSA 717
Query: 103 LQAKNLPLDVAIE-CLTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQ 161
++++ IE L ++ +D+ + K+ ED L K + A K AL+++VS ++
Sbjct: 718 KRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQE 777
Query: 162 LCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDF 221
+ L+E Q +++ + E++E + N+ + + S T +Q
Sbjct: 778 MDKLKE---QYDAELQALRESVEE---------ATKNVEV------LASRSNTSEQ---- 815
Query: 222 SRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKW 281
D+A EM+ + E N +L+ + E +R+ ++++ +LK
Sbjct: 816 -----DQAGTEMRVKL---------LQEENEKLQGRSEELE----RRVAQLQRQIEDLKG 857
Query: 282 QEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDE 341
E E + + + +IR LEE L + EA + R +E + AQ L+
Sbjct: 858 DEAKAKETLKKYEGEIRQLEEAL------VHARKEEKEAVSARRALENELEAAQGNLSQT 911
Query: 342 VHQLEATIAALKQKLAQAQ 360
+ + LK++ Q +
Sbjct: 912 TQEQKQLSEKLKEESEQKE 930
Score = 34.3 bits (77), Expect = 0.22
Identities = 46/222 (20%), Positives = 94/222 (42%), Gaps = 38/222 (17%)
Query: 21 SYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDK 80
S+L ++L + ++ Q L E NN + E +R+R E+++ + E+L +
Sbjct: 1053 SHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSR--EQMEQLR--NELLQE 1108
Query: 81 CLTDLDAEIDALT--------------------QMKESAEQNLQAKNLPLDVAIEC---- 116
D E D ++ KE ++A+ L+ +E
Sbjct: 1109 RAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERD 1168
Query: 117 -----LTLRESRRDIDVVKDPVEDE---LHKEVEVIEATKKALQQKVSQAFEQLCLLQEV 168
L+ R R + + V+DE L + + + KA++++V +A E++ L+
Sbjct: 1169 RANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESS 1228
Query: 169 QQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPD 210
+++L + +M+ E +G LN ++ LK P++V D
Sbjct: 1229 KKKLQRELEEQMDMNEHLQG--QLNSMKKDLRLKKLPSKVLD 1268
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 56.2 bits (134), Expect = 6e-08
Identities = 83/380 (21%), Positives = 169/380 (44%), Gaps = 44/380 (11%)
Query: 26 TNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
+N L+RD +RQE + L+ + + E + +E+ + + + D +TD
Sbjct: 76 SNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKE--LEKYQGLQQQEAKPDGLVTDS 133
Query: 86 DAEIDALTQMKESAE-QNLQAKNL-------PLDVAIECLTLRESRRDIDVVKDPVE--- 134
AE+ +L Q E A+ +N K + +A E ++ + +++ E
Sbjct: 134 SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV 193
Query: 135 ----DELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCL 190
+EL+KE VI+ K L Q+ E + +L++ Q+ + M+ + ++R
Sbjct: 194 TRLTEELNKEATVIQDLKTELLQR--PGIEDVAVLKKELVQVQT----LMDNMTLERERE 247
Query: 191 SLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAET 250
S L+ L+ ++ T+ S+ + A+ + A ++E L +
Sbjct: 248 SEKLKDECKKLQ---SQYASSEATI------SQLRSELAKGPQEVAVYVQELQKLK-SSV 297
Query: 251 NNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLS 310
N + + TE +K E+ Y++L +EK+ E +++ ++DL + L
Sbjct: 298 NELTQKNQTLTENLLKK-----EQDYTKL--EEKHNEESVSKKNIQATLHQKDLDCQQLQ 350
Query: 311 LKLSHTRLEARTYRPNVELC-RDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKH 369
+LS + E +R +VEL + +A L +E+ ++E LK + Q Q + +H
Sbjct: 351 SRLSAS--ETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQH 408
Query: 370 LARLQADIACKANSMLLDTK 389
+LQ++I + +S LL+T+
Sbjct: 409 GLQLQSEIN-QLHSKLLETE 427
Score = 42.7 bits (99), Expect = 6e-04
Identities = 77/361 (21%), Positives = 154/361 (42%), Gaps = 36/361 (9%)
Query: 31 QRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVER--IDTVNRWKEMLDKCLTDLDAE 88
+R Q+ L E N + + D +T L++R I+ V +L K L +
Sbjct: 182 ERSLREAAEQKVTRLTEELNKEATVIQ-DLKTELLQRPGIEDV----AVLKKELVQVQTL 236
Query: 89 IDALTQMKESAEQNL--QAKNLPLDVAIECLTLRESRRDIDVVKDPVEDELH-KEVEVIE 145
+D +T +E + L + K L A T+ + R ++ K P E ++ +E++ ++
Sbjct: 237 MDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSEL--AKGPQEVAVYVQELQKLK 294
Query: 146 ATKKALQQKVSQAFEQLCLLQEVQQQLNSDH----------RGKMETLEIDRGCLSLNLR 195
++ L QK E L ++ +L H + + ++D L L
Sbjct: 295 SSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLS 354
Query: 196 SPNISL-KVDPTRVPDGSTTLQQWDDFS----RFNKDRAE-AEMKAATELREATALTIAE 249
+ SL ++ G T + ++ S ++ +AE +++ E +E L +
Sbjct: 355 ASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQS 414
Query: 250 TNNELEAQRVATEFAFRK---RLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRT 306
N+L ++ + TE + RL+E ++ SE K +K +++A+LQ + LEE L+
Sbjct: 415 EINQLHSKLLETERQLGEAHGRLKEQRQLSSE-KLMDKE--QQVADLQLKLSRLEEQLKE 471
Query: 307 KLL-SLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDA 365
K+ S +L H + + + + L + + LE + + K + Q+ L+A
Sbjct: 472 KVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN-LEA 530
Query: 366 L 366
L
Sbjct: 531 L 531
Score = 42.7 bits (99), Expect = 6e-04
Identities = 66/344 (19%), Positives = 153/344 (44%), Gaps = 40/344 (11%)
Query: 66 ERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRD 125
E+ ++ + E L+ + L+A+ + KE A Q+LQ + R+ D
Sbjct: 716 EKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQ-------------RQLNTD 762
Query: 126 IDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFE----QLCLLQEVQQQLNSDHRGKME 181
+++ + +L E E++ +T+ LQ+K S+A E +L +E +Q L D +
Sbjct: 763 LELRATELSKQLEMEKEIVSSTRLDLQKK-SEALESIKQKLTKQEEEKQILKQDFETLSQ 821
Query: 182 TLEIDRGCLSLNLRSPNISL---KVDPTRVPDGSTTLQQWDDFSRFNKD--RAEAEMKAA 236
+I L+ +++ L K++ + +T++ D S+ + +++E +
Sbjct: 822 ETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK--DKLSKVSDSLKNSKSEFEKE 879
Query: 237 TELREATALTIAETNNELEAQ-------RVATEFAFRKRLREMEKVYSELKWQEKNTLEE 289
+ +A L + +T EL+ Q + + +K L + ++ +LK + + E+
Sbjct: 880 NQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQ 939
Query: 290 IAELQEDIRHLEED---LRTKLLSLKLSHTRLEARTYRPNVELC-----RDQAQYGLTDE 341
+ + Q ++ E++ L+ + LK S + + + EL + + + L +
Sbjct: 940 LIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQ 999
Query: 342 VHQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKANSML 385
+ Q +AA K+K++ Q+ + + +LQ+D + + +L
Sbjct: 1000 LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELL 1043
Score = 39.7 bits (91), Expect = 0.005
Identities = 76/380 (20%), Positives = 153/380 (40%), Gaps = 70/380 (18%)
Query: 46 RNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQA 105
+N+T + + + + T+L E+ + + K+ + L D + L ++E +L
Sbjct: 303 KNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR 362
Query: 106 KNLPLDVAIECLT-LRESRRDIDVVKDPVEDE---LHKEVEVIEATKKALQQKVSQAFEQ 161
++ L E L+E +++ ++ E L ++ E E LQ +++Q +
Sbjct: 363 IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
Query: 162 LCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPD-------GSTT 214
L E ++QL H E ++ L ++ L++ +R+ + ST
Sbjct: 423 LL---ETERQLGEAHGRLKEQRQLSSEKL-MDKEQQVADLQLKLSRLEEQLKEKVTNSTE 478
Query: 215 LQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEA---------QRVATEFAF 265
LQ D+ + + + L+++T + E N+LE Q++ A
Sbjct: 479 LQH-------QLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEAL 531
Query: 266 RKRLRE--------MEKVYSELKWQEKNT--LEEIAE----LQEDIRHLEEDLRTKLLSL 311
++ +E E +Y++++ E T L ++ E LQE + L E L+ + S
Sbjct: 532 LQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESH 591
Query: 312 KLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLA 371
K QAQ L D+V + +A + A + ++ + +++ L L
Sbjct: 592 K--------------------QAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLN 631
Query: 372 R-----LQADIACKANSMLL 386
Q DI KA + LL
Sbjct: 632 ESKEKVSQLDIQIKAKTELL 651
>gi|210032790 hypothetical protein LOC27146 [Homo sapiens]
Length = 1060
Score = 55.5 bits (132), Expect = 9e-08
Identities = 63/304 (20%), Positives = 137/304 (45%), Gaps = 46/304 (15%)
Query: 120 RESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGK 179
++ +R+++ + V + KE++ +E K AL K+ + ++ L+E QQ + G
Sbjct: 455 KKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGA 514
Query: 180 MET-----------LEIDRGCLSLNLRSP--------------NISLKVDPTRV------ 208
E+ LE CL L+ SP S + + T+V
Sbjct: 515 EESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGS 574
Query: 209 ----PDGSTTLQQWDDFSRFNKD--RAEAEMKA-ATELREATALTIAETNNELEAQRVAT 261
P GS ++ R +D +A+++A +++++A + +L+A + +
Sbjct: 575 DPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLS 634
Query: 262 EFAFRKRLREMEKVYSE---LKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHT-R 317
+ K RE+++ + +K Q + + + + E RH E + L + SH+ +
Sbjct: 635 DLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQ 694
Query: 318 LEARTYRPNVELCRDQAQYGLTDEVHQLEA----TIAALKQKLAQAQDALDALCKHLARL 373
++ +T+R ++ ++A+ L +E +++A + +L+Q+L++ Q A K L L
Sbjct: 695 IQHQTHRLELQALEEKARQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEAL 754
Query: 374 QADI 377
QA++
Sbjct: 755 QAEL 758
Score = 40.4 bits (93), Expect = 0.003
Identities = 90/395 (22%), Positives = 161/395 (40%), Gaps = 70/395 (17%)
Query: 24 LSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLT 83
L + +LQ+ + + E+ R ET + + E ++ ER+ T++R EML+
Sbjct: 104 LESALELQKRLTEEALAESASCRLETKERELRVEAEH----AERVLTLSR--EMLE-LKA 156
Query: 84 DLDAEIDALTQMKESAEQNL-----QAKNLP------LDVAIECLTLRESRRDIDVVKDP 132
D + + LT + + + L + K+ P +V +E LR + +
Sbjct: 157 DYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYAR 216
Query: 133 VEDELHKEVE-VIEATKKALQQKVSQAF---------------EQLCLLQEVQQQLNSD- 175
+EL E EA ++A+QQ VSQA Q LQ ++L D
Sbjct: 217 KAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDL 276
Query: 176 -HRG-KMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEM 233
HRG K+ L+ L ++ ++ LK + T ++ + KDR +
Sbjct: 277 EHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQE 336
Query: 234 KAATELREATALTIAETN------NELEA--------QRVATEFAFRKRLREME---KVY 276
T+ +A + N N+LEA Q E K +M+ +
Sbjct: 337 CRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEAS 396
Query: 277 SELKWQEKNTLEEIAEL----QEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRD 332
+E ++ ++ E++ ++ +E+ +HL++ L +L L HT +E ++ R +VE R
Sbjct: 397 AETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHT-VEIKSVRSSVEAERK 455
Query: 333 QAQYGL-----------TDEVHQLEATIAALKQKL 356
+ Q + E+ QLE AAL KL
Sbjct: 456 KLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKL 490
Score = 36.6 bits (83), Expect = 0.045
Identities = 68/316 (21%), Positives = 125/316 (39%), Gaps = 58/316 (18%)
Query: 17 WHTNSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKE 76
W L N Q+Q A ++ + R L + EH R +I + ++ +
Sbjct: 247 WQEKESDLRKNFQVQESA---LQAQVRKLEGDL-------EHRGR-----KISDLKKYAQ 291
Query: 77 MLDKCLTDLDAEIDALTQMKESAEQNLQAKNL--PLDVAIECLTLRESR--RDIDVVKDP 132
L + + DLD ++ Q E++E AK L L VA + + L+E R + D +K
Sbjct: 292 KLKERIQDLDVQLKEARQ--ENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTE 349
Query: 133 V--EDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCL 190
+ E+++ +E +EA QQ S E C+ Q + + E ++
Sbjct: 350 LVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMK------ 403
Query: 191 SLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMK-AATELREATALTIAE 249
QQ+++ R K + E E K +L + + +
Sbjct: 404 -------------------------QQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKK 438
Query: 250 TNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLL 309
E+++ R + E +K RE+E E++ K + +EI +L+E+ L L+ LL
Sbjct: 439 HTVEIKSVRSSVEAERKKLQREVEAQLEEVR---KKSEKEIKQLEEEKAALNVKLQNSLL 495
Query: 310 SLKLSHTRLEARTYRP 325
+ ++ RP
Sbjct: 496 EVLRLEEFIQQNKTRP 511
>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 54.7 bits (130), Expect = 2e-07
Identities = 54/243 (22%), Positives = 106/243 (43%), Gaps = 23/243 (9%)
Query: 136 ELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLR 195
+L +++ +E T LQ+++S A +++C LQE QQQL + L +R S+ +
Sbjct: 216 DLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNE-----LIRERSEKSVEIT 270
Query: 196 SPNISLKVD---PTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNN 252
+ ++++ TR W K R E E + ++ T + IA
Sbjct: 271 KQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLL 330
Query: 253 ELEA-QRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSL 311
E + ++ T A R++L E++ + ++ + +N + + E I E + S+
Sbjct: 331 EKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSM 390
Query: 312 KLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLE----ATIAALKQKLAQAQDALDALC 367
K RL+ ++A+ G + H+L+ I AL+ +L+Q + +L
Sbjct: 391 KQMEERLQH----------SERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLE 440
Query: 368 KHL 370
K L
Sbjct: 441 KEL 443
Score = 42.4 bits (98), Expect = 8e-04
Identities = 61/330 (18%), Positives = 133/330 (40%), Gaps = 21/330 (6%)
Query: 57 EHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIEC 116
EH+ T ++++ + V L + DL +ID L + ++ L A
Sbjct: 189 EHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSA------ATDRI 242
Query: 117 LTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLC-LLQEVQQQLNSD 175
+L+E ++ + + + + K VE+ + K + Q + L + +V +QL +
Sbjct: 243 CSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEE 302
Query: 176 HRGKME---TLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTL-QQWDDFSRFNKDRAEA 231
+ ++E LE+ G + + L+ D D L QQ ++ N
Sbjct: 303 KKVRLELEKELELQIG-MKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHK 361
Query: 232 EMKAATELREAT-ALT--------IAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQ 282
A + L++ A+T + + ++E + +E A + K+ EL +
Sbjct: 362 AQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGR 421
Query: 283 EKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEV 342
++++L E LE++L+++ + L+ ++ Q GL E+
Sbjct: 422 IGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKEL 481
Query: 343 HQLEATIAALKQKLAQAQDALDALCKHLAR 372
+L+ A L++ + + AL + HL++
Sbjct: 482 RELQDEKAELQKICEEQEQALQEMGLHLSQ 511
>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 54.7 bits (130), Expect = 2e-07
Identities = 54/243 (22%), Positives = 106/243 (43%), Gaps = 23/243 (9%)
Query: 136 ELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLR 195
+L +++ +E T LQ+++S A +++C LQE QQQL + L +R S+ +
Sbjct: 216 DLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNE-----LIRERSEKSVEIT 270
Query: 196 SPNISLKVD---PTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNN 252
+ ++++ TR W K R E E + ++ T + IA
Sbjct: 271 KQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLL 330
Query: 253 ELEA-QRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSL 311
E + ++ T A R++L E++ + ++ + +N + + E I E + S+
Sbjct: 331 EKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSM 390
Query: 312 KLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLE----ATIAALKQKLAQAQDALDALC 367
K RL+ ++A+ G + H+L+ I AL+ +L+Q + +L
Sbjct: 391 KQMEERLQH----------SERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLE 440
Query: 368 KHL 370
K L
Sbjct: 441 KEL 443
Score = 42.4 bits (98), Expect = 8e-04
Identities = 61/330 (18%), Positives = 133/330 (40%), Gaps = 21/330 (6%)
Query: 57 EHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIEC 116
EH+ T ++++ + V L + DL +ID L + ++ L A
Sbjct: 189 EHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSA------ATDRI 242
Query: 117 LTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLC-LLQEVQQQLNSD 175
+L+E ++ + + + + K VE+ + K + Q + L + +V +QL +
Sbjct: 243 CSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEE 302
Query: 176 HRGKME---TLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTL-QQWDDFSRFNKDRAEA 231
+ ++E LE+ G + + L+ D D L QQ ++ N
Sbjct: 303 KKVRLELEKELELQIG-MKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHK 361
Query: 232 EMKAATELREAT-ALT--------IAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQ 282
A + L++ A+T + + ++E + +E A + K+ EL +
Sbjct: 362 AQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGR 421
Query: 283 EKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEV 342
++++L E LE++L+++ + L+ ++ Q GL E+
Sbjct: 422 IGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKEL 481
Query: 343 HQLEATIAALKQKLAQAQDALDALCKHLAR 372
+L+ A L++ + + AL + HL++
Sbjct: 482 RELQDEKAELQKICEEQEQALQEMGLHLSQ 511
>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo
sapiens]
Length = 708
Score = 54.7 bits (130), Expect = 2e-07
Identities = 54/243 (22%), Positives = 106/243 (43%), Gaps = 23/243 (9%)
Query: 136 ELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLR 195
+L +++ +E T LQ+++S A +++C LQE QQQL + L +R S+ +
Sbjct: 324 DLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNE-----LIRERSEKSVEIT 378
Query: 196 SPNISLKVD---PTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNN 252
+ ++++ TR W K R E E + ++ T + IA
Sbjct: 379 KQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLL 438
Query: 253 ELEA-QRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSL 311
E + ++ T A R++L E++ + ++ + +N + + E I E + S+
Sbjct: 439 EKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSM 498
Query: 312 KLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLE----ATIAALKQKLAQAQDALDALC 367
K RL+ ++A+ G + H+L+ I AL+ +L+Q + +L
Sbjct: 499 KQMEERLQH----------SERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLE 548
Query: 368 KHL 370
K L
Sbjct: 549 KEL 551
Score = 42.4 bits (98), Expect = 8e-04
Identities = 61/330 (18%), Positives = 133/330 (40%), Gaps = 21/330 (6%)
Query: 57 EHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIEC 116
EH+ T ++++ + V L + DL +ID L + ++ L A
Sbjct: 297 EHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSA------ATDRI 350
Query: 117 LTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLC-LLQEVQQQLNSD 175
+L+E ++ + + + + K VE+ + K + Q + L + +V +QL +
Sbjct: 351 CSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEE 410
Query: 176 HRGKME---TLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTL-QQWDDFSRFNKDRAEA 231
+ ++E LE+ G + + L+ D D L QQ ++ N
Sbjct: 411 KKVRLELEKELELQIG-MKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHK 469
Query: 232 EMKAATELREAT-ALT--------IAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQ 282
A + L++ A+T + + ++E + +E A + K+ EL +
Sbjct: 470 AQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGR 529
Query: 283 EKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEV 342
++++L E LE++L+++ + L+ ++ Q GL E+
Sbjct: 530 IGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKEL 589
Query: 343 HQLEATIAALKQKLAQAQDALDALCKHLAR 372
+L+ A L++ + + AL + HL++
Sbjct: 590 RELQDEKAELQKICEEQEQALQEMGLHLSQ 619
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 54.3 bits (129), Expect = 2e-07
Identities = 76/328 (23%), Positives = 149/328 (45%), Gaps = 59/328 (17%)
Query: 62 TRLVERIDTVNRWKEMLDKCLTDLDAEIDAL-TQMKESAEQNLQAKNLPLDVAIECLTLR 120
+ L E +++ + +K DL E++AL T+++++ LD LR
Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDT-----------LDSTAAQQELR 1162
Query: 121 ESR-RDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGK 179
R ++++++K +E+E + EA + ++QK SQA E+L E +++ ++
Sbjct: 1163 SKREQEVNILKKTLEEE----AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKA 1218
Query: 180 METLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATEL 239
+TLE +RG L+ ++ L Q S + + EA+++ EL
Sbjct: 1219 KQTLENERGELANEVK------------------VLLQGKGDSEHKRKKVEAQLQ---EL 1257
Query: 240 REATALTIAETNNELEAQRVATEFAFR--KRLREMEKVYSELKWQEKNTLEEI------- 290
+ + N E +RV TE A + K E++ V L + + +
Sbjct: 1258 Q-------VKFN---EGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALE 1307
Query: 291 AELQEDIRHLEEDLRTKL-LSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATI 349
++LQ+ L+E+ R KL LS KL E ++R +E ++A++ L ++ L A +
Sbjct: 1308 SQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEE-EEEAKHNLEKQIATLHAQV 1366
Query: 350 AALKQKLAQAQDALDALCKHLARLQADI 377
A +K+K+ + L+ + +LQ D+
Sbjct: 1367 ADMKKKMEDSVGCLETAEEVKRKLQKDL 1394
Score = 52.4 bits (124), Expect = 8e-07
Identities = 61/275 (22%), Positives = 117/275 (42%), Gaps = 32/275 (11%)
Query: 92 LTQMKESAEQNLQAKNLPLDVAIE-----CLTLRESRRDIDVVKDPVEDELHKEVEVIEA 146
LT+M E+ + L A+ L L ++ C E R + K +E+ H +E
Sbjct: 868 LTEM-ETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEE 926
Query: 147 TKKALQQKVSQAFEQLCLLQEVQQQLNSDH--RGKMETLEIDRGCLSLNLRSPNISLKVD 204
++ Q ++ + +QE+++QL + R K++ ++ L I L+
Sbjct: 927 EEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQ 986
Query: 205 PTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFA 264
++ L+ D + F + E E K+ + +A+ N+ EA E
Sbjct: 987 NCKLAKEKKLLE--DRIAEFTTNLTEEEEKSKS---------LAKLKNKHEAMITDLEER 1035
Query: 265 FR---KRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEAR 321
R K+ +E+EK +L+ + ++IAELQ I L+ L K L+ + R+E
Sbjct: 1036 LRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEE 1095
Query: 322 TYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKL 356
+ N+ L ++ +LE+ I+ L++ L
Sbjct: 1096 AAQKNMAL----------KKIRELESQISELQEDL 1120
Score = 43.9 bits (102), Expect = 3e-04
Identities = 81/394 (20%), Positives = 154/394 (39%), Gaps = 57/394 (14%)
Query: 58 HDNRTRLVERID-TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIEC 116
H+ + ++++ T R ++ LD L DLD + ++SA NL+ K D
Sbjct: 1401 HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQ-------RQSA-CNLEKKQKKFD----- 1447
Query: 117 LTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDH 176
L + I D E E +L + + +A EQ L+ +LN
Sbjct: 1448 -QLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELE----RLNKQF 1502
Query: 177 RGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKD---RAEAEM 233
R +ME L + + ++ S + +V + T L++ +D + +D R E +
Sbjct: 1503 RTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNL 1562
Query: 234 KA---------------ATELREATALTIAETNNELEAQRVATEFAF--RKRLR-EMEKV 275
+A + E ++ + E ELE +R A RK+L +++ +
Sbjct: 1563 QAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDL 1622
Query: 276 YSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQ 335
+ + KN E I +L++ ++ +D +L + S + A+ +L +A
Sbjct: 1623 EAHIDSANKNRDEAIKQLRK-LQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEA- 1680
Query: 336 YGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKANSMLLDTKCMDTRR 395
E+ QL+ +AA ++ QAQ D L + ANS ++ +R
Sbjct: 1681 -----EMIQLQEELAAAERAKRQAQQERDELADEI----------ANSSGKGALALEEKR 1725
Query: 396 KLTVPAERFVPEVDTFTRTTNSTLSPLKSCQLEL 429
+L + E++ T LK L++
Sbjct: 1726 RLEARIAQLEEELEEEQGNTELINDRLKKANLQI 1759
Score = 39.7 bits (91), Expect = 0.005
Identities = 74/364 (20%), Positives = 150/364 (41%), Gaps = 37/364 (10%)
Query: 27 NAQLQRDASHQIRQEARVLRN-ETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
++Q + + Q+ Q RV N E QT+ +E R L + + + K + +
Sbjct: 1194 HSQAVEELAEQLEQTKRVKANLEKAKQTLENE---RGELANEVKVLLQGKGDSEHKRKKV 1250
Query: 86 DAEIDALTQMK----ESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDELHKEV 141
+A++ L Q+K E L K L V ++ +T S+ D +L K+
Sbjct: 1251 EAQLQEL-QVKFNEGERVRTELADKVTKLQVELDNVTGLLSQ------SDSKSSKLTKDF 1303
Query: 142 EVIEA----TKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
+E+ T++ LQ++ Q L++V+ + NS R ++E E + L + +
Sbjct: 1304 SALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNS-FREQLEEEEEAKHNLEKQIATL 1362
Query: 198 NISLKVDPTRVPDGSTTLQQWDDFSR-FNKDRAEAEMKAATELREATALTIAETNNELEA 256
+ + ++ D L+ ++ R KD + ++ L +T + E
Sbjct: 1363 HAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQEL 1422
Query: 257 QRVATEFAFRKR----LREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLK 312
+ + +++ L + +K + +L +EK + AE ++ + TK LS
Sbjct: 1423 DDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALS-- 1480
Query: 313 LSHTRLEARTYRPNVELCRDQAQYGLTD----------EVHQLEATIAALKQKLAQAQDA 362
L+ EA + +E Q + + D VH+LE + AL+Q++ + +
Sbjct: 1481 LARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQ 1540
Query: 363 LDAL 366
L+ L
Sbjct: 1541 LEEL 1544
Score = 39.7 bits (91), Expect = 0.005
Identities = 87/388 (22%), Positives = 143/388 (36%), Gaps = 72/388 (18%)
Query: 64 LVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKN---LPLDVAIECLTLR 120
L+ D V + L+K L+ +++ + E E LQA L L+V ++ +
Sbjct: 1509 LMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAM--- 1565
Query: 121 ESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKM 180
K E +L E E KK L ++V + +L E +++ S
Sbjct: 1566 ---------KAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL----EDERKQRSMAVAAR 1612
Query: 181 ETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELR 240
+ LE+D L ++ S N + D Q D + RA E A
Sbjct: 1613 KKLEMDLKDLEAHIDSANKNR--DEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKE 1670
Query: 241 EATALTIAETNN-ELEAQRVATEFAFRKRLREMEKVYSE---------LKWQEKNTLE-E 289
L E +L+ + A E A R+ +E +++ E L +EK LE
Sbjct: 1671 NEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEAR 1730
Query: 290 IAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYG------------ 337
IA+L+E++ EE T+L++ +L L+ ++ L R AQ
Sbjct: 1731 IAQLEEELE--EEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNK 1788
Query: 338 ----------------LTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKA 381
+ LEA IA L+++L A CK + R + K
Sbjct: 1789 ELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEK----KL 1844
Query: 382 NSMLLDTKCMDTRRKLTVPAERFVPEVD 409
+LL D RR AE++ + D
Sbjct: 1845 KDVLLQVD--DERRN----AEQYKDQAD 1866
>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
Length = 1094
Score = 53.9 bits (128), Expect = 3e-07
Identities = 71/364 (19%), Positives = 150/364 (41%), Gaps = 31/364 (8%)
Query: 28 AQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTR--LVERIDTVNRWK---EMLDKCL 82
++L R A +Q R L ++ + +E + R ++ +++ +WK + L++ L
Sbjct: 445 SELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERAL 504
Query: 83 TDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECL-TLRESRRDIDVVKDPVEDELHKEV 141
+D LT + L A++ + LR+ D+ + E+ELH +
Sbjct: 505 EKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKE 564
Query: 142 EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
E + K Q L EV+ L++ HR + E + + + + ++
Sbjct: 565 EKLRDIKS----------HQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEE 614
Query: 202 KV---DPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATE-------LREATALTIAETN 251
++ ++ D + L+ + + RA+ K A E L++ + LT +
Sbjct: 615 EIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKS 674
Query: 252 NELEAQRVATEFAFRKRL--REMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLL 309
+ E + T+ + + RE++ + S L+ + + I EL + + + + +
Sbjct: 675 RDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIR 734
Query: 310 SLKLSHTRLE--ARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALC 367
+LK + A+ +R +E + Q LT+E+ Q E LK K +D L+
Sbjct: 735 TLKAESLEEKNMAKIHRGQLEKLKSQCDR-LTEELTQNENENKKLKLKYQCLKDQLEERE 793
Query: 368 KHLA 371
KH++
Sbjct: 794 KHIS 797
Score = 39.7 bits (91), Expect = 0.005
Identities = 79/357 (22%), Positives = 141/357 (39%), Gaps = 60/357 (16%)
Query: 60 NRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAE-QNLQAKNLPLDVAIECLT 118
N + + ++ V R E DK L ++++ LT+ E+ E Q LQ + ++ T
Sbjct: 373 NFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDT 432
Query: 119 LRESRRDIDVVKDPVEDELHKEVEVIEATKKA------------LQQKVSQAFEQLCL-L 165
R+ D+ EL + E +ATK+A L+++ + E L L
Sbjct: 433 CEAERKHADLQIS----ELTRHAE--DATKQAERYLSELQQSEALKEEAEKRREDLKLKA 486
Query: 166 QEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFN 225
QE +Q H+ LE + N LK LQQ ++ +
Sbjct: 487 QESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKEL 546
Query: 226 KD----RAEAEMKAATELREATALTIAETNNELEAQR-VATEFAFRKRLREMEKVYSELK 280
D RA E + ++ + + + + ELE + + T L++ K+ S++K
Sbjct: 547 NDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMK 606
Query: 281 WQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTD 340
++ + EEIAEL++ + + KLL ++ +
Sbjct: 607 VEKAHLEEEIAELKKS----QAQDKAKLLEMQ---------------------------E 635
Query: 341 EVHQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKANSMLLDTKCMDTRRKL 397
+ L A A L KLA+ + A A+ K L +D+ +A S +T + T+ KL
Sbjct: 636 SIKDLSAIRADLANKLAEEERAKKAVLKDL----SDLTAQAKSRDEETATIITQLKL 688
Score = 34.7 bits (78), Expect = 0.17
Identities = 74/348 (21%), Positives = 139/348 (39%), Gaps = 29/348 (8%)
Query: 39 RQEARVLRNETNNQTIWDEHDNRTRLVERI-DTVNRWKEMLDKCLTDLDAEIDALT-QMK 96
+QE R E Q + E LVER D + L + L +A+ D +K
Sbjct: 212 KQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIK 271
Query: 97 ESAEQNLQAKN-LPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKV 155
Q KN L ++ + L +S + + VE EL ++ E +K LQ +V
Sbjct: 272 NKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVE-ELRTQLTKAEGDRKGLQHQV 330
Query: 156 SQAFEQLCLLQEVQQQLNSDHRG---KMETLEIDRGCLSLNLRSPNISLKVDPT------ 206
SQ +Q Q+ Q + RG + + LE L + L ++ +++
Sbjct: 331 SQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMER 390
Query: 207 RVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFR 266
+ + + Q ++ +R ++ + +++ L+E I + EA+R +
Sbjct: 391 KDKEKAHLASQVENLTRELENGEKQQLQMLDRLKE-----IQNHFDTCEAERKHADLQIS 445
Query: 267 KRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTK----LLSLKLSHTRLEART 322
+ R E + + + + L++ L+E+ EDL+ K + KL H +LE
Sbjct: 446 ELTRHAEDATKQAE-RYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERAL 504
Query: 323 YRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHL 370
+ + + LT + +Q+ LK +L A ++ L K L
Sbjct: 505 EK------QSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKEL 546
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 53.5 bits (127), Expect = 4e-07
Identities = 68/362 (18%), Positives = 147/362 (40%), Gaps = 64/362 (17%)
Query: 34 ASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALT 93
A++ + +ARV ET + +L+ K+ L +TDL + I L+
Sbjct: 426 AANNTQLQARVEMLET------ERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLS 479
Query: 94 QMKESAEQNLQAKNLPLDVAIECLT---------LRESRRDIDVVKDPVEDELHKEVEVI 144
Q KE EQ QA L + LT +++ +++ +K +++ + + +
Sbjct: 480 QAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTL 539
Query: 145 EATKKA----------LQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNL 194
+ ++A L + Q +QL + E Q+ DH ++ T +R +L
Sbjct: 540 QQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEER---EASL 596
Query: 195 RSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNEL 254
R + +LK L+ + + + +++ A E R++ ++ +
Sbjct: 597 RERDAALK-----------QLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQ----- 640
Query: 255 EAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLS 314
AQR E + +++ E++ + ++ ++AEL+ +R
Sbjct: 641 -AQREKAELS--RKVEELQACVETARQEQHEAQAQVAELELQLR---------------- 681
Query: 315 HTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
+ + T + V +DQ Q L L+ T +L+++ +A DAL+ + ++ L+
Sbjct: 682 -SEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740
Query: 375 AD 376
A+
Sbjct: 741 AE 742
Score = 40.8 bits (94), Expect = 0.002
Identities = 79/367 (21%), Positives = 145/367 (39%), Gaps = 62/367 (16%)
Query: 25 STNAQLQRDASHQIRQEARVLRNETNNQTIWDEH--DNRTRLVERIDTVNR----WKEML 78
++N+ + S +R+E + LR E Q + E+ T ER + + + W+E
Sbjct: 1277 ASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKF 1336
Query: 79 ---DKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIE-CLTLRESRRDIDVVKDPVE 134
++ L+ L E T + + L AK+L + E + R +++ K
Sbjct: 1337 FQKEQALSTLQLEH---TSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAG 1393
Query: 135 D----------------ELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRG 178
L ++V E T + L+ + + EQL +L++ L ++RG
Sbjct: 1394 GLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRG 1453
Query: 179 KMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATE 238
E + R L + L + V RA+AE + A
Sbjct: 1454 LGERANLGRQFLEVELDQAREKYVQELAAV-------------------RADAETRLAEV 1494
Query: 239 LREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIR 298
REA + T ELE E A K L E ++ +E+ L E Q ++
Sbjct: 1495 QREAQS-----TARELEVMTAKYEGAKVKVLEERQRFQ-----EERQKLTAQVE-QLEVF 1543
Query: 299 HLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLT-DEVHQLEATIAALKQKLA 357
E+ + + LS KL+ + ++ + ++ QAQ G + E +L+A + L+ +L+
Sbjct: 1544 QREQTKQVEELSKKLADSDQASKVQQQKLKAV--QAQGGESQQEAQRLQAQLNELQAQLS 1601
Query: 358 QAQDALD 364
Q + A +
Sbjct: 1602 QKEQAAE 1608
Score = 34.7 bits (78), Expect = 0.17
Identities = 68/322 (21%), Positives = 135/322 (41%), Gaps = 21/322 (6%)
Query: 87 AEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVIEA 146
A+ D + AE ++ +N + +E TL+E+ K+ + EL K + +EA
Sbjct: 1016 AQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAK-LRGLEA 1074
Query: 147 TK----KALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLK 202
+ + L+Q V Q EQL +E + S + + G LR+ L+
Sbjct: 1075 AQIKELEELRQTVKQLKEQLAK-KEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLE 1133
Query: 203 VDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNEL-EAQRVAT 261
+ + + +L++ + R ++ ++ ++ E A + + + L AQR
Sbjct: 1134 QQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELA 1193
Query: 262 EFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEAR 321
AFR ++++ K E K Q +E I LEE++ +L+ ++ E++
Sbjct: 1194 --AFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEV--SILNRQVLEKEGESK 1249
Query: 322 TYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKA 381
+ + + + L + + L+A A+ + A+ AL + L R +A+ A
Sbjct: 1250 ELK-RLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSL-REEAEKQRVA 1307
Query: 382 NSMLLDTKCMDTRRKLTVPAER 403
+ L R++LT AER
Sbjct: 1308 SENL--------RQELTSQAER 1321
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 53.1 bits (126), Expect = 5e-07
Identities = 87/365 (23%), Positives = 153/365 (41%), Gaps = 75/365 (20%)
Query: 33 DASHQIRQEARVLRNETN--NQTIWDEHDNRTRLVERIDTVN-RWKEMLDKCLTDLDAEI 89
D HQ RQ A L + +Q + +E R E D +E K L+ A
Sbjct: 1435 DLDHQ-RQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE 1493
Query: 90 DALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVIEATKK 149
+AL +E QN Q LR D+ KD V +H+ +E +K+
Sbjct: 1494 EALEAKEEFERQNKQ--------------LRADMEDLMSSKDDVGKNVHE----LEKSKR 1535
Query: 150 ALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVP 209
AL+Q+V + Q L+E++ +L + K+ L +N+++ + D
Sbjct: 1536 ALEQQVEEMRTQ---LEELEDELQATEDAKLR--------LEVNMQAMKAQFERD----- 1579
Query: 210 DGSTTLQQWDDFSRFNKDRAEAEMKAATEL-------REATALTIAETN------NELEA 256
LQ D+ N+++ +K EL R+ AL +A +LEA
Sbjct: 1580 -----LQTRDE---QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEA 1631
Query: 257 QRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHT 316
Q A A + ++++ K+ +++K ++ LEE +++I ++ KL SL+
Sbjct: 1632 QIEAANKARDEVIKQLRKLQAQMKDYQRE-LEEARASRDEIFAQSKESEKKLKSLEAEIL 1690
Query: 317 RLE-----ARTYRPNVELCRDQ----------AQYGLTDEVHQLEATIAALKQKLAQAQD 361
+L+ + R + E RD+ + L DE +LEA IA L+++L + Q
Sbjct: 1691 QLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQS 1750
Query: 362 ALDAL 366
++ L
Sbjct: 1751 NMELL 1755
Score = 45.4 bits (106), Expect = 1e-04
Identities = 80/383 (20%), Positives = 159/383 (41%), Gaps = 40/383 (10%)
Query: 41 EARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAE 100
EA+ N Q D D L+ D V + L+K L+ +++ + E E
Sbjct: 1497 EAKEEFERQNKQLRADMED----LMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELE 1552
Query: 101 QNLQAKN---LPLDVAIECLTLRESRRDIDVVKDPVEDE---LHKEVEVIEAT----KKA 150
LQA L L+V ++ + + RD+ + E++ L K+V +EA +K
Sbjct: 1553 DELQATEDAKLRLEVNMQAMKA-QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1611
Query: 151 LQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPD 210
V+ + L++++ Q+ + ++ + E ++ LR +K D
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIK--------QLRKLQAQMK-------D 1656
Query: 211 GSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLR 270
L++ +R ++D A+ K + + ++ I + EL + A A ++R
Sbjct: 1657 YQRELEE----ARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDE 1712
Query: 271 EMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRP---NV 327
+++ + + L+E L+ I LEE+L + +++L + R T + N
Sbjct: 1713 LADEITNSASGKSA-LLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNA 1771
Query: 328 ELCRDQAQYGLTDEV-HQLEATIAALKQKLAQAQDALDALCK-HLARLQADIACKANSML 385
EL +++ +D QLE LK KL + + A+ + K ++ L+A I +
Sbjct: 1772 ELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLE 1831
Query: 386 LDTKCMDTRRKLTVPAERFVPEV 408
+ K KL E+ + E+
Sbjct: 1832 QEAKERAAANKLVRRTEKKLKEI 1854
Score = 39.7 bits (91), Expect = 0.005
Identities = 61/277 (22%), Positives = 113/277 (40%), Gaps = 40/277 (14%)
Query: 92 LTQMKESAEQNLQAKNL---PLDVAIECLT-LRESRRDIDVVKDPVEDELHKEVEVIEAT 147
L +M+ +Q L+ KN+ L E E R + K +E+ LH +E
Sbjct: 875 LEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEE 934
Query: 148 KKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTR 207
++ Q ++ + +Q++++QL+ + G + L++++ ++ +
Sbjct: 935 EERNQILQNEKKKMQAHIQDLEEQLDEEE-GARQKLQLEKVTAEAKIKKMEEEI------ 987
Query: 208 VPDGSTTLQQWDDFSRFNKDR-------AEAEMKAATELREATALTIAETNNELEAQRVA 260
L D S+F K++ AE + A E E A +A+ N+ E
Sbjct: 988 -------LLLEDQNSKFIKEKKLMEDRIAECSSQLAEE--EEKAKNLAKIRNKQEVMISD 1038
Query: 261 TEFAFRKRLR---EMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTR 317
E +K + E+EK +L + + ++IAELQ I L+ L K L+ + R
Sbjct: 1039 LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALAR 1098
Query: 318 LEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQ 354
+ T N L V +L+A IA L++
Sbjct: 1099 GDDETLHKNNAL----------KVVRELQAQIAELQE 1125
Score = 37.7 bits (86), Expect = 0.020
Identities = 75/332 (22%), Positives = 137/332 (41%), Gaps = 47/332 (14%)
Query: 80 KCLTDLDAEIDALTQMKESAEQNL-QAKNLPLDVAIECLTLRESRRD-IDVVKDPVEDEL 137
K + +L A+I L + ES + + +A+ D++ E L+ D +D E
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRT 1170
Query: 138 HKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
+E EV E KKAL+++ Q+ Q+++Q+ + E LE + NL
Sbjct: 1171 KREQEVAEL-KKALEEETKNHEAQI---QDMRQRHATALEELSEQLEQAKR-FKANLEKN 1225
Query: 198 NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKA-------ATELREATALTIAET 250
L+ D + LQQ S + + +A+++ LR A ++
Sbjct: 1226 KQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKL 1285
Query: 251 NNEL--------EAQRVATEFA-----FRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
NEL EA++ +FA +L++ +++ E Q+ N I +L+E+
Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK 1345
Query: 298 RHLEE----------DLRTKLLSL--KLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQL 345
L+E +L ++L+L +L+ T+ + +E L + +L
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIE--------SLEEAKKKL 1397
Query: 346 EATIAALKQKLAQAQDALDALCKHLARLQADI 377
AL Q+L + A D L K RLQ ++
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTKNRLQQEL 1429
Score = 34.7 bits (78), Expect = 0.17
Identities = 82/409 (20%), Positives = 152/409 (37%), Gaps = 52/409 (12%)
Query: 41 EARVLRNETNNQTIWDEHDNRTR----LVERIDTVNRWKEMLDKCLTDLDAEIDALTQ-- 94
E+RV E NQ + +E L E++D ++ L +A+I + +
Sbjct: 928 ESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEI 987
Query: 95 --MKESAEQNLQAKNLPLDVAIECLT-----------LRESRRDIDVVKDPVEDELHKEV 141
+++ + ++ K L D EC + L + R +V+ +E+ L KE
Sbjct: 988 LLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEE 1047
Query: 142 EV---IEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPN 198
+ +E K+ L + + +Q+ LQ +L K E L+ N
Sbjct: 1048 KTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN 1107
Query: 199 ISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMK---------------------AAT 237
+LKV + LQ+ + + ++++AE + + A
Sbjct: 1108 NALKV-VRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ 1166
Query: 238 ELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
ELR +AE LE + E + + EL Q + A L+++
Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226
Query: 298 RHLEEDLRTKLLSLK-LSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKL 356
+ LE D + +K L + E+ R ++ + Q + E +L +A KL
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLD-AQVQELHAKVSEGDRLRVELAEKASKL 1285
Query: 357 AQAQDALDALCKHLARLQ---ADIACKANSMLLDTKCM---DTRRKLTV 399
D + L + + A A S L DT+ + +TR+KL +
Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNL 1334
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 51.6 bits (122), Expect = 1e-06
Identities = 75/349 (21%), Positives = 156/349 (44%), Gaps = 33/349 (9%)
Query: 57 EHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIEC 116
E DN ER D + + K L+ + +++ ++ +E L AK L+ EC
Sbjct: 894 EQDNLADAEERCDQLIKNKIQLEAKVKEMNERLED----EEEMNAELTAKKRKLED--EC 947
Query: 117 LTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDH 176
L+ D+++ VE E H E K L ++++ E + L + ++ L H
Sbjct: 948 SELKRDIDDLELTLAKVEKEKH----ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1003
Query: 177 RGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAA 236
+ ++ L+ + ++ L + L+ +V D +L+Q + R + +RA+ +++
Sbjct: 1004 QQALDDLQAEEDKVN-TLTKAKVKLE---QQVDDLEGSLEQ-EKKVRMDLERAKRKLEGD 1058
Query: 237 TELREATALTIAETNNELEAQRVATEF---AFRKRLREMEKVYSELKWQEKNTLEEIAEL 293
+L + + + + +L+ + +F A R+ + + + S+L+ + K I EL
Sbjct: 1059 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 1118
Query: 294 QEDI------RHLEEDLRTKLL-SLKLSHTRLEARTYRPNVEL---CRDQAQY-----GL 338
+E++ R E LR+ L L+ RLE +V++ + +A++ L
Sbjct: 1119 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 1178
Query: 339 TDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKANSMLLD 387
+ Q EAT AAL++K A + L +L R++ + + + L+
Sbjct: 1179 EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1227
Score = 49.3 bits (116), Expect = 7e-06
Identities = 75/393 (19%), Positives = 165/393 (41%), Gaps = 42/393 (10%)
Query: 41 EARVLRNETNNQTIWDEH-DNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESA 99
E L++E + +H D+ L E+ID + R K+ L+K ++ E+D +T +
Sbjct: 1179 EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVT---SNM 1235
Query: 100 EQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAF 159
EQ ++AK ++ C TL ED++++ E T++++ SQ
Sbjct: 1236 EQIIKAK---ANLEKMCRTL--------------EDQMNEHRSKAEETQRSVNDLTSQRA 1278
Query: 160 EQLCLLQEVQQQLNSDHRGKMETL--EIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQ 217
+ E+ +QL+ + E L ++ RG L+ + ++ +++ L
Sbjct: 1279 KLQTENGELSRQLD-----EKEALISQLTRGKLTYTQQLEDLKRQLE--EEVKAKNALAH 1331
Query: 218 WDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYS 277
+R + D + + TE + +++ N+E+ R E +R E+E+
Sbjct: 1332 ALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEA-- 1389
Query: 278 ELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYG 337
+K + + E +E + E + K SL+ + RL+ V++ R A
Sbjct: 1390 -----KKKLAQRLQEAEEAV----EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA 1440
Query: 338 LTDEVHQ-LEATIAALKQKLAQAQDALDALCKHLARLQADIACKANSMLLDTKCMDTRRK 396
D+ + + +A KQK ++Q L++ K L ++ N+ + ++T ++
Sbjct: 1441 ALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKR 1500
Query: 397 LTVPAERFVPEVDTFTRTTNSTLSPLKSCQLEL 429
+ + ++ ++ T+ L+ + +L
Sbjct: 1501 ENKNLQEEISDLTEQLGSSGKTIHELEKVRKQL 1533
Score = 43.1 bits (100), Expect = 5e-04
Identities = 63/291 (21%), Positives = 129/291 (44%), Gaps = 34/291 (11%)
Query: 90 DALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDEL---HKEVEVIEA 146
+ T++KE+ E++ +A+ L+ + ++L + + D+ + +D L + + +
Sbjct: 854 EEFTRLKEALEKS-EARRKELEEKM--VSLLQEKNDLQLQVQAEQDNLADAEERCDQLIK 910
Query: 147 TKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMET----LEIDRGCLSLNLRSPNISLK 202
K L+ KV + E+L +E+ +L + R K+E L+ D L L L
Sbjct: 911 NKIQLEAKVKEMNERLEDEEEMNAELTAKKR-KLEDECSELKRDIDDLELTLAKVEKEKH 969
Query: 203 VDPTRVPDGSTTLQQWDDF----SRFNKDRAEAEMKAATELR----EATALTIAETNNEL 254
+V + + + D+ ++ K EA +A +L+ + LT A+ E
Sbjct: 970 ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQ 1029
Query: 255 EAQRVATEFAFRKRLR-EMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKL 313
+ + K++R ++E+ +L+ K T E I +L+ D + L+E L+ K L
Sbjct: 1030 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNA 1089
Query: 314 SHTRLEARTYRPNVELCRDQAQYG--LTDEVHQLEATIAALKQKLAQAQDA 362
+ R+E D+ G L ++ +L+A I L+++L + A
Sbjct: 1090 LNARIE------------DEQALGSQLQKKLKELQARIEELEEELEAERTA 1128
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 51.6 bits (122), Expect = 1e-06
Identities = 98/403 (24%), Positives = 174/403 (43%), Gaps = 56/403 (13%)
Query: 11 RFQLPDWHTNSYLLSTNAQ-LQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERID 69
R QL + LL Q L+ +A+ RQ ++V E ++ + + ++L RI+
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV---EEELFSVRVQMEELSKLKARIE 2248
Query: 70 TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRE-SRRDIDV 128
NR + DK T + +A +MK+ AE+ A L + A E LR+ + D+
Sbjct: 2249 AENRALILRDKDNTQRFLQEEA-EKMKQVAEE---AARLSV-AAQEAARLRQLAEEDLAQ 2303
Query: 129 VKDPVEDELHKEVEVI-EATK-----KALQQKVSQAFEQLCLLQE----VQQQLNSDHRG 178
+ E L ++++ + EAT+ + LQQ+ A EQ LQE + QQL + +G
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363
Query: 179 KMETLEIDR-GCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-AEMKAA 236
TLE +R L ++ + + L+V + +D RF K E E
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2419
Query: 237 TELREATALTIAETNNELEAQRVATEF-------AFRKRLREMEKVYSELKW-------- 281
TEL +T+ +T LE QR ++ A + RE EK+ E K
Sbjct: 2420 TELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476
Query: 282 ---QEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLE-------ARTYRPNVELCR 331
Q++ L+E LQ+ ++ L + ++ +LE A+ + E R
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536
Query: 332 DQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
Q Q + E +L A++ +++ +A++ + + L +L+
Sbjct: 2537 QQQQ--MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577
Score = 38.9 bits (89), Expect = 0.009
Identities = 82/380 (21%), Positives = 145/380 (38%), Gaps = 46/380 (12%)
Query: 28 AQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDA 87
AQL+R + A+ LR E + R R E + RW+ ++ L L
Sbjct: 1590 AQLERSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALR-LRL 1646
Query: 88 EIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPV------EDELHKEV 141
+ + + Q K A+ + + + RE+RR + V E EL K+
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAE--------REARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 142 EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
++ E T QQ+++ E + L E +Q + E + R + + +
Sbjct: 1699 QLAEGTA---QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755
Query: 202 KVDPTR------VPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELE 255
++ R + + ++ S +K R EAE EL E A A
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1815
Query: 256 AQRVATEFAFRKRLREMEKVYSE----------LKWQEKNTLEEIAELQEDIRHLEED-- 303
+++A E A R+R E E+V +E LK + + L+E E +R L ED
Sbjct: 1816 QRQLAEEDAARQR-AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 304 LRTKLLSLKLSHTRLEARTYRPNVELCRD---QAQYGLTDEV----HQLEATIAALKQKL 356
+ + L + + + + + D + Q GL ++ Q+E I ALK
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934
Query: 357 AQAQDALDALCKHLARLQAD 376
+A L L R++++
Sbjct: 1935 EKAAAGKAELELELGRIRSN 1954
Score = 38.1 bits (87), Expect = 0.016
Identities = 84/399 (21%), Positives = 165/399 (41%), Gaps = 34/399 (8%)
Query: 28 AQLQRDASHQIRQEARVLRNETNNQT--IWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
AQ + D ++ Q + +E Q + D R ++ E I + E +L
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1944
Query: 86 DAEIDALTQMKESAEQNLQAKN-LPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVI 144
+ E L +++ +AE L++K L+ A + E R ++ V+ L E E
Sbjct: 1945 ELE---LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 145 EATKKALQQ--KVSQAFEQLCLL-----QEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
K AL++ ++ E+ L QE +QL + L+ + + ++
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 198 NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-----AEMKAATELREATALTIAETNN 252
L+ + L+ + +R + AE AE +AA R+ + +
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 253 ELEAQ-RVATEFAFRKRLREMEKVYSELKWQEKNTLEE----IAELQEDIRHLEEDLRTK 307
E +AQ R + A K +E E+ + E+ L + AE+++ + E+ LR K
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181
Query: 308 LLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDAL- 366
+ E T R +E D + L +E+ +L+A ++ +Q ++ L ++
Sbjct: 2182 ------AQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 367 --CKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAER 403
+ L++L+A I + +++L K +T+R L AE+
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAEK 2272
Score = 33.5 bits (75), Expect = 0.38
Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 23/210 (10%)
Query: 120 RESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVS--QAFEQLCLLQEVQQQLNSDHR 177
++S D + +++ + EL +E E ++ K LQ K Q +Q LLQE Q S
Sbjct: 2439 QQSDHDAERLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2497
Query: 178 GKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAAT 237
K L+ +R + L+Q + E +
Sbjct: 2498 EKDSLLQRERF-------------------IEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2538
Query: 238 ELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
+ E + + E ++ E R++ E++++ + + QE+ EE L+E +
Sbjct: 2539 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598
Query: 298 RHLEEDLRTKLL-SLKLSHTRLEARTYRPN 326
+ LEE R L S +++ +++ A PN
Sbjct: 2599 QLLEEQHRAALAHSEEVTASQVAATKTLPN 2628
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 51.6 bits (122), Expect = 1e-06
Identities = 98/403 (24%), Positives = 174/403 (43%), Gaps = 56/403 (13%)
Query: 11 RFQLPDWHTNSYLLSTNAQ-LQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERID 69
R QL + LL Q L+ +A+ RQ ++V E ++ + + ++L RI+
Sbjct: 2196 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV---EEELFSVRVQMEELSKLKARIE 2252
Query: 70 TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRE-SRRDIDV 128
NR + DK T + +A +MK+ AE+ A L + A E LR+ + D+
Sbjct: 2253 AENRALILRDKDNTQRFLQEEA-EKMKQVAEE---AARLSV-AAQEAARLRQLAEEDLAQ 2307
Query: 129 VKDPVEDELHKEVEVI-EATK-----KALQQKVSQAFEQLCLLQE----VQQQLNSDHRG 178
+ E L ++++ + EAT+ + LQQ+ A EQ LQE + QQL + +G
Sbjct: 2308 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2367
Query: 179 KMETLEIDR-GCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-AEMKAA 236
TLE +R L ++ + + L+V + +D RF K E E
Sbjct: 2368 FQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2423
Query: 237 TELREATALTIAETNNELEAQRVATEF-------AFRKRLREMEKVYSELKW-------- 281
TEL +T+ +T LE QR ++ A + RE EK+ E K
Sbjct: 2424 TELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2480
Query: 282 ---QEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLE-------ARTYRPNVELCR 331
Q++ L+E LQ+ ++ L + ++ +LE A+ + E R
Sbjct: 2481 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2540
Query: 332 DQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
Q Q + E +L A++ +++ +A++ + + L +L+
Sbjct: 2541 QQQQ--MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2581
Score = 38.9 bits (89), Expect = 0.009
Identities = 82/380 (21%), Positives = 145/380 (38%), Gaps = 46/380 (12%)
Query: 28 AQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDA 87
AQL+R + A+ LR E + R R E + RW+ ++ L L
Sbjct: 1594 AQLERSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALR-LRL 1650
Query: 88 EIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPV------EDELHKEV 141
+ + + Q K A+ + + + RE+RR + V E EL K+
Sbjct: 1651 QAEEVAQQKSLAQAEAEKQKEEAE--------REARRRGKAEEQAVRQRELAEQELEKQR 1702
Query: 142 EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
++ E T QQ+++ E + L E +Q + E + R + + +
Sbjct: 1703 QLAEGTA---QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1759
Query: 202 KVDPTR------VPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELE 255
++ R + + ++ S +K R EAE EL E A A
Sbjct: 1760 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1819
Query: 256 AQRVATEFAFRKRLREMEKVYSE----------LKWQEKNTLEEIAELQEDIRHLEED-- 303
+++A E A R+R E E+V +E LK + + L+E E +R L ED
Sbjct: 1820 QRQLAEEDAARQR-AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1878
Query: 304 LRTKLLSLKLSHTRLEARTYRPNVELCRD---QAQYGLTDEV----HQLEATIAALKQKL 356
+ + L + + + + + D + Q GL ++ Q+E I ALK
Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1938
Query: 357 AQAQDALDALCKHLARLQAD 376
+A L L R++++
Sbjct: 1939 EKAAAGKAELELELGRIRSN 1958
Score = 38.1 bits (87), Expect = 0.016
Identities = 84/399 (21%), Positives = 165/399 (41%), Gaps = 34/399 (8%)
Query: 28 AQLQRDASHQIRQEARVLRNETNNQT--IWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
AQ + D ++ Q + +E Q + D R ++ E I + E +L
Sbjct: 1889 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1948
Query: 86 DAEIDALTQMKESAEQNLQAKN-LPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVI 144
+ E L +++ +AE L++K L+ A + E R ++ V+ L E E
Sbjct: 1949 ELE---LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2005
Query: 145 EATKKALQQ--KVSQAFEQLCLL-----QEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
K AL++ ++ E+ L QE +QL + L+ + + ++
Sbjct: 2006 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2065
Query: 198 NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-----AEMKAATELREATALTIAETNN 252
L+ + L+ + +R + AE AE +AA R+ + +
Sbjct: 2066 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2125
Query: 253 ELEAQ-RVATEFAFRKRLREMEKVYSELKWQEKNTLEE----IAELQEDIRHLEEDLRTK 307
E +AQ R + A K +E E+ + E+ L + AE+++ + E+ LR K
Sbjct: 2126 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2185
Query: 308 LLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDAL- 366
+ E T R +E D + L +E+ +L+A ++ +Q ++ L ++
Sbjct: 2186 ------AQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2238
Query: 367 --CKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAER 403
+ L++L+A I + +++L K +T+R L AE+
Sbjct: 2239 VQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAEK 2276
Score = 33.5 bits (75), Expect = 0.38
Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 23/210 (10%)
Query: 120 RESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVS--QAFEQLCLLQEVQQQLNSDHR 177
++S D + +++ + EL +E E ++ K LQ K Q +Q LLQE Q S
Sbjct: 2443 QQSDHDAERLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2501
Query: 178 GKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAAT 237
K L+ +R + L+Q + E +
Sbjct: 2502 EKDSLLQRERF-------------------IEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2542
Query: 238 ELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
+ E + + E ++ E R++ E++++ + + QE+ EE L+E +
Sbjct: 2543 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2602
Query: 298 RHLEEDLRTKLL-SLKLSHTRLEARTYRPN 326
+ LEE R L S +++ +++ A PN
Sbjct: 2603 QLLEEQHRAALAHSEEVTASQVAATKTLPN 2632
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 51.6 bits (122), Expect = 1e-06
Identities = 98/403 (24%), Positives = 174/403 (43%), Gaps = 56/403 (13%)
Query: 11 RFQLPDWHTNSYLLSTNAQ-LQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERID 69
R QL + LL Q L+ +A+ RQ ++V E ++ + + ++L RI+
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV---EEELFSVRVQMEELSKLKARIE 2248
Query: 70 TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRE-SRRDIDV 128
NR + DK T + +A +MK+ AE+ A L + A E LR+ + D+
Sbjct: 2249 AENRALILRDKDNTQRFLQEEA-EKMKQVAEE---AARLSV-AAQEAARLRQLAEEDLAQ 2303
Query: 129 VKDPVEDELHKEVEVI-EATK-----KALQQKVSQAFEQLCLLQE----VQQQLNSDHRG 178
+ E L ++++ + EAT+ + LQQ+ A EQ LQE + QQL + +G
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363
Query: 179 KMETLEIDR-GCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-AEMKAA 236
TLE +R L ++ + + L+V + +D RF K E E
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2419
Query: 237 TELREATALTIAETNNELEAQRVATEF-------AFRKRLREMEKVYSELKW-------- 281
TEL +T+ +T LE QR ++ A + RE EK+ E K
Sbjct: 2420 TELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476
Query: 282 ---QEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLE-------ARTYRPNVELCR 331
Q++ L+E LQ+ ++ L + ++ +LE A+ + E R
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536
Query: 332 DQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
Q Q + E +L A++ +++ +A++ + + L +L+
Sbjct: 2537 QQQQ--MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577
Score = 38.9 bits (89), Expect = 0.009
Identities = 82/380 (21%), Positives = 145/380 (38%), Gaps = 46/380 (12%)
Query: 28 AQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDA 87
AQL+R + A+ LR E + R R E + RW+ ++ L L
Sbjct: 1590 AQLERSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALR-LRL 1646
Query: 88 EIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPV------EDELHKEV 141
+ + + Q K A+ + + + RE+RR + V E EL K+
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAE--------REARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 142 EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
++ E T QQ+++ E + L E +Q + E + R + + +
Sbjct: 1699 QLAEGTA---QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755
Query: 202 KVDPTR------VPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELE 255
++ R + + ++ S +K R EAE EL E A A
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1815
Query: 256 AQRVATEFAFRKRLREMEKVYSE----------LKWQEKNTLEEIAELQEDIRHLEED-- 303
+++A E A R+R E E+V +E LK + + L+E E +R L ED
Sbjct: 1816 QRQLAEEDAARQR-AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 304 LRTKLLSLKLSHTRLEARTYRPNVELCRD---QAQYGLTDEV----HQLEATIAALKQKL 356
+ + L + + + + + D + Q GL ++ Q+E I ALK
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934
Query: 357 AQAQDALDALCKHLARLQAD 376
+A L L R++++
Sbjct: 1935 EKAAAGKAELELELGRIRSN 1954
Score = 38.1 bits (87), Expect = 0.016
Identities = 84/399 (21%), Positives = 165/399 (41%), Gaps = 34/399 (8%)
Query: 28 AQLQRDASHQIRQEARVLRNETNNQT--IWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
AQ + D ++ Q + +E Q + D R ++ E I + E +L
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1944
Query: 86 DAEIDALTQMKESAEQNLQAKN-LPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVI 144
+ E L +++ +AE L++K L+ A + E R ++ V+ L E E
Sbjct: 1945 ELE---LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 145 EATKKALQQ--KVSQAFEQLCLL-----QEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
K AL++ ++ E+ L QE +QL + L+ + + ++
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 198 NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-----AEMKAATELREATALTIAETNN 252
L+ + L+ + +R + AE AE +AA R+ + +
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 253 ELEAQ-RVATEFAFRKRLREMEKVYSELKWQEKNTLEE----IAELQEDIRHLEEDLRTK 307
E +AQ R + A K +E E+ + E+ L + AE+++ + E+ LR K
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181
Query: 308 LLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDAL- 366
+ E T R +E D + L +E+ +L+A ++ +Q ++ L ++
Sbjct: 2182 ------AQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 367 --CKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAER 403
+ L++L+A I + +++L K +T+R L AE+
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAEK 2272
Score = 33.5 bits (75), Expect = 0.38
Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 23/210 (10%)
Query: 120 RESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVS--QAFEQLCLLQEVQQQLNSDHR 177
++S D + +++ + EL +E E ++ K LQ K Q +Q LLQE Q S
Sbjct: 2439 QQSDHDAERLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2497
Query: 178 GKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAAT 237
K L+ +R + L+Q + E +
Sbjct: 2498 EKDSLLQRERF-------------------IEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2538
Query: 238 ELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
+ E + + E ++ E R++ E++++ + + QE+ EE L+E +
Sbjct: 2539 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598
Query: 298 RHLEEDLRTKLL-SLKLSHTRLEARTYRPN 326
+ LEE R L S +++ +++ A PN
Sbjct: 2599 QLLEEQHRAALAHSEEVTASQVAATKTLPN 2628
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 51.6 bits (122), Expect = 1e-06
Identities = 98/403 (24%), Positives = 174/403 (43%), Gaps = 56/403 (13%)
Query: 11 RFQLPDWHTNSYLLSTNAQ-LQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERID 69
R QL + LL Q L+ +A+ RQ ++V E ++ + + ++L RI+
Sbjct: 2160 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV---EEELFSVRVQMEELSKLKARIE 2216
Query: 70 TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRE-SRRDIDV 128
NR + DK T + +A +MK+ AE+ A L + A E LR+ + D+
Sbjct: 2217 AENRALILRDKDNTQRFLQEEA-EKMKQVAEE---AARLSV-AAQEAARLRQLAEEDLAQ 2271
Query: 129 VKDPVEDELHKEVEVI-EATK-----KALQQKVSQAFEQLCLLQE----VQQQLNSDHRG 178
+ E L ++++ + EAT+ + LQQ+ A EQ LQE + QQL + +G
Sbjct: 2272 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2331
Query: 179 KMETLEIDR-GCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-AEMKAA 236
TLE +R L ++ + + L+V + +D RF K E E
Sbjct: 2332 FQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2387
Query: 237 TELREATALTIAETNNELEAQRVATEF-------AFRKRLREMEKVYSELKW-------- 281
TEL +T+ +T LE QR ++ A + RE EK+ E K
Sbjct: 2388 TELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2444
Query: 282 ---QEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLE-------ARTYRPNVELCR 331
Q++ L+E LQ+ ++ L + ++ +LE A+ + E R
Sbjct: 2445 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2504
Query: 332 DQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
Q Q + E +L A++ +++ +A++ + + L +L+
Sbjct: 2505 QQQQ--MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2545
Score = 38.9 bits (89), Expect = 0.009
Identities = 82/380 (21%), Positives = 145/380 (38%), Gaps = 46/380 (12%)
Query: 28 AQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDA 87
AQL+R + A+ LR E + R R E + RW+ ++ L L
Sbjct: 1558 AQLERSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALR-LRL 1614
Query: 88 EIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPV------EDELHKEV 141
+ + + Q K A+ + + + RE+RR + V E EL K+
Sbjct: 1615 QAEEVAQQKSLAQAEAEKQKEEAE--------REARRRGKAEEQAVRQRELAEQELEKQR 1666
Query: 142 EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
++ E T QQ+++ E + L E +Q + E + R + + +
Sbjct: 1667 QLAEGTA---QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1723
Query: 202 KVDPTR------VPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELE 255
++ R + + ++ S +K R EAE EL E A A
Sbjct: 1724 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1783
Query: 256 AQRVATEFAFRKRLREMEKVYSE----------LKWQEKNTLEEIAELQEDIRHLEED-- 303
+++A E A R+R E E+V +E LK + + L+E E +R L ED
Sbjct: 1784 QRQLAEEDAARQR-AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1842
Query: 304 LRTKLLSLKLSHTRLEARTYRPNVELCRD---QAQYGLTDEV----HQLEATIAALKQKL 356
+ + L + + + + + D + Q GL ++ Q+E I ALK
Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1902
Query: 357 AQAQDALDALCKHLARLQAD 376
+A L L R++++
Sbjct: 1903 EKAAAGKAELELELGRIRSN 1922
Score = 38.1 bits (87), Expect = 0.016
Identities = 84/399 (21%), Positives = 165/399 (41%), Gaps = 34/399 (8%)
Query: 28 AQLQRDASHQIRQEARVLRNETNNQT--IWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
AQ + D ++ Q + +E Q + D R ++ E I + E +L
Sbjct: 1853 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1912
Query: 86 DAEIDALTQMKESAEQNLQAKN-LPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVI 144
+ E L +++ +AE L++K L+ A + E R ++ V+ L E E
Sbjct: 1913 ELE---LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1969
Query: 145 EATKKALQQ--KVSQAFEQLCLL-----QEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
K AL++ ++ E+ L QE +QL + L+ + + ++
Sbjct: 1970 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2029
Query: 198 NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-----AEMKAATELREATALTIAETNN 252
L+ + L+ + +R + AE AE +AA R+ + +
Sbjct: 2030 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2089
Query: 253 ELEAQ-RVATEFAFRKRLREMEKVYSELKWQEKNTLEE----IAELQEDIRHLEEDLRTK 307
E +AQ R + A K +E E+ + E+ L + AE+++ + E+ LR K
Sbjct: 2090 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2149
Query: 308 LLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDAL- 366
+ E T R +E D + L +E+ +L+A ++ +Q ++ L ++
Sbjct: 2150 ------AQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2202
Query: 367 --CKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAER 403
+ L++L+A I + +++L K +T+R L AE+
Sbjct: 2203 VQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAEK 2240
Score = 33.5 bits (75), Expect = 0.38
Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 23/210 (10%)
Query: 120 RESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVS--QAFEQLCLLQEVQQQLNSDHR 177
++S D + +++ + EL +E E ++ K LQ K Q +Q LLQE Q S
Sbjct: 2407 QQSDHDAERLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2465
Query: 178 GKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAAT 237
K L+ +R + L+Q + E +
Sbjct: 2466 EKDSLLQRERF-------------------IEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2506
Query: 238 ELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
+ E + + E ++ E R++ E++++ + + QE+ EE L+E +
Sbjct: 2507 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2566
Query: 298 RHLEEDLRTKLL-SLKLSHTRLEARTYRPN 326
+ LEE R L S +++ +++ A PN
Sbjct: 2567 QLLEEQHRAALAHSEEVTASQVAATKTLPN 2596
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 51.6 bits (122), Expect = 1e-06
Identities = 98/403 (24%), Positives = 174/403 (43%), Gaps = 56/403 (13%)
Query: 11 RFQLPDWHTNSYLLSTNAQ-LQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERID 69
R QL + LL Q L+ +A+ RQ ++V E ++ + + ++L RI+
Sbjct: 2329 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV---EEELFSVRVQMEELSKLKARIE 2385
Query: 70 TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRE-SRRDIDV 128
NR + DK T + +A +MK+ AE+ A L + A E LR+ + D+
Sbjct: 2386 AENRALILRDKDNTQRFLQEEA-EKMKQVAEE---AARLSV-AAQEAARLRQLAEEDLAQ 2440
Query: 129 VKDPVEDELHKEVEVI-EATK-----KALQQKVSQAFEQLCLLQE----VQQQLNSDHRG 178
+ E L ++++ + EAT+ + LQQ+ A EQ LQE + QQL + +G
Sbjct: 2441 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2500
Query: 179 KMETLEIDR-GCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-AEMKAA 236
TLE +R L ++ + + L+V + +D RF K E E
Sbjct: 2501 FQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2556
Query: 237 TELREATALTIAETNNELEAQRVATEF-------AFRKRLREMEKVYSELKW-------- 281
TEL +T+ +T LE QR ++ A + RE EK+ E K
Sbjct: 2557 TELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2613
Query: 282 ---QEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLE-------ARTYRPNVELCR 331
Q++ L+E LQ+ ++ L + ++ +LE A+ + E R
Sbjct: 2614 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2673
Query: 332 DQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
Q Q + E +L A++ +++ +A++ + + L +L+
Sbjct: 2674 QQQQ--MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2714
Score = 38.9 bits (89), Expect = 0.009
Identities = 82/380 (21%), Positives = 145/380 (38%), Gaps = 46/380 (12%)
Query: 28 AQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDA 87
AQL+R + A+ LR E + R R E + RW+ ++ L L
Sbjct: 1727 AQLERSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALR-LRL 1783
Query: 88 EIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPV------EDELHKEV 141
+ + + Q K A+ + + + RE+RR + V E EL K+
Sbjct: 1784 QAEEVAQQKSLAQAEAEKQKEEAE--------REARRRGKAEEQAVRQRELAEQELEKQR 1835
Query: 142 EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
++ E T QQ+++ E + L E +Q + E + R + + +
Sbjct: 1836 QLAEGTA---QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1892
Query: 202 KVDPTR------VPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELE 255
++ R + + ++ S +K R EAE EL E A A
Sbjct: 1893 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1952
Query: 256 AQRVATEFAFRKRLREMEKVYSE----------LKWQEKNTLEEIAELQEDIRHLEED-- 303
+++A E A R+R E E+V +E LK + + L+E E +R L ED
Sbjct: 1953 QRQLAEEDAARQR-AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011
Query: 304 LRTKLLSLKLSHTRLEARTYRPNVELCRD---QAQYGLTDEV----HQLEATIAALKQKL 356
+ + L + + + + + D + Q GL ++ Q+E I ALK
Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 2071
Query: 357 AQAQDALDALCKHLARLQAD 376
+A L L R++++
Sbjct: 2072 EKAAAGKAELELELGRIRSN 2091
Score = 38.1 bits (87), Expect = 0.016
Identities = 84/399 (21%), Positives = 165/399 (41%), Gaps = 34/399 (8%)
Query: 28 AQLQRDASHQIRQEARVLRNETNNQT--IWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
AQ + D ++ Q + +E Q + D R ++ E I + E +L
Sbjct: 2022 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 2081
Query: 86 DAEIDALTQMKESAEQNLQAKN-LPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVI 144
+ E L +++ +AE L++K L+ A + E R ++ V+ L E E
Sbjct: 2082 ELE---LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2138
Query: 145 EATKKALQQ--KVSQAFEQLCLL-----QEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
K AL++ ++ E+ L QE +QL + L+ + + ++
Sbjct: 2139 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2198
Query: 198 NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-----AEMKAATELREATALTIAETNN 252
L+ + L+ + +R + AE AE +AA R+ + +
Sbjct: 2199 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2258
Query: 253 ELEAQ-RVATEFAFRKRLREMEKVYSELKWQEKNTLEE----IAELQEDIRHLEEDLRTK 307
E +AQ R + A K +E E+ + E+ L + AE+++ + E+ LR K
Sbjct: 2259 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2318
Query: 308 LLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDAL- 366
+ E T R +E D + L +E+ +L+A ++ +Q ++ L ++
Sbjct: 2319 ------AQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2371
Query: 367 --CKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAER 403
+ L++L+A I + +++L K +T+R L AE+
Sbjct: 2372 VQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAEK 2409
Score = 33.5 bits (75), Expect = 0.38
Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 23/210 (10%)
Query: 120 RESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVS--QAFEQLCLLQEVQQQLNSDHR 177
++S D + +++ + EL +E E ++ K LQ K Q +Q LLQE Q S
Sbjct: 2576 QQSDHDAERLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2634
Query: 178 GKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAAT 237
K L+ +R + L+Q + E +
Sbjct: 2635 EKDSLLQRERF-------------------IEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2675
Query: 238 ELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
+ E + + E ++ E R++ E++++ + + QE+ EE L+E +
Sbjct: 2676 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2735
Query: 298 RHLEEDLRTKLL-SLKLSHTRLEARTYRPN 326
+ LEE R L S +++ +++ A PN
Sbjct: 2736 QLLEEQHRAALAHSEEVTASQVAATKTLPN 2765
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 51.6 bits (122), Expect = 1e-06
Identities = 98/403 (24%), Positives = 174/403 (43%), Gaps = 56/403 (13%)
Query: 11 RFQLPDWHTNSYLLSTNAQ-LQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERID 69
R QL + LL Q L+ +A+ RQ ++V E ++ + + ++L RI+
Sbjct: 2170 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV---EEELFSVRVQMEELSKLKARIE 2226
Query: 70 TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRE-SRRDIDV 128
NR + DK T + +A +MK+ AE+ A L + A E LR+ + D+
Sbjct: 2227 AENRALILRDKDNTQRFLQEEA-EKMKQVAEE---AARLSV-AAQEAARLRQLAEEDLAQ 2281
Query: 129 VKDPVEDELHKEVEVI-EATK-----KALQQKVSQAFEQLCLLQE----VQQQLNSDHRG 178
+ E L ++++ + EAT+ + LQQ+ A EQ LQE + QQL + +G
Sbjct: 2282 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2341
Query: 179 KMETLEIDR-GCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-AEMKAA 236
TLE +R L ++ + + L+V + +D RF K E E
Sbjct: 2342 FQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2397
Query: 237 TELREATALTIAETNNELEAQRVATEF-------AFRKRLREMEKVYSELKW-------- 281
TEL +T+ +T LE QR ++ A + RE EK+ E K
Sbjct: 2398 TELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2454
Query: 282 ---QEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLE-------ARTYRPNVELCR 331
Q++ L+E LQ+ ++ L + ++ +LE A+ + E R
Sbjct: 2455 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2514
Query: 332 DQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
Q Q + E +L A++ +++ +A++ + + L +L+
Sbjct: 2515 QQQQ--MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2555
Score = 38.9 bits (89), Expect = 0.009
Identities = 82/380 (21%), Positives = 145/380 (38%), Gaps = 46/380 (12%)
Query: 28 AQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDA 87
AQL+R + A+ LR E + R R E + RW+ ++ L L
Sbjct: 1568 AQLERSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALR-LRL 1624
Query: 88 EIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPV------EDELHKEV 141
+ + + Q K A+ + + + RE+RR + V E EL K+
Sbjct: 1625 QAEEVAQQKSLAQAEAEKQKEEAE--------REARRRGKAEEQAVRQRELAEQELEKQR 1676
Query: 142 EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
++ E T QQ+++ E + L E +Q + E + R + + +
Sbjct: 1677 QLAEGTA---QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1733
Query: 202 KVDPTR------VPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELE 255
++ R + + ++ S +K R EAE EL E A A
Sbjct: 1734 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1793
Query: 256 AQRVATEFAFRKRLREMEKVYSE----------LKWQEKNTLEEIAELQEDIRHLEED-- 303
+++A E A R+R E E+V +E LK + + L+E E +R L ED
Sbjct: 1794 QRQLAEEDAARQR-AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1852
Query: 304 LRTKLLSLKLSHTRLEARTYRPNVELCRD---QAQYGLTDEV----HQLEATIAALKQKL 356
+ + L + + + + + D + Q GL ++ Q+E I ALK
Sbjct: 1853 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1912
Query: 357 AQAQDALDALCKHLARLQAD 376
+A L L R++++
Sbjct: 1913 EKAAAGKAELELELGRIRSN 1932
Score = 38.1 bits (87), Expect = 0.016
Identities = 84/399 (21%), Positives = 165/399 (41%), Gaps = 34/399 (8%)
Query: 28 AQLQRDASHQIRQEARVLRNETNNQT--IWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
AQ + D ++ Q + +E Q + D R ++ E I + E +L
Sbjct: 1863 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1922
Query: 86 DAEIDALTQMKESAEQNLQAKN-LPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVI 144
+ E L +++ +AE L++K L+ A + E R ++ V+ L E E
Sbjct: 1923 ELE---LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1979
Query: 145 EATKKALQQ--KVSQAFEQLCLL-----QEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
K AL++ ++ E+ L QE +QL + L+ + + ++
Sbjct: 1980 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2039
Query: 198 NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-----AEMKAATELREATALTIAETNN 252
L+ + L+ + +R + AE AE +AA R+ + +
Sbjct: 2040 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2099
Query: 253 ELEAQ-RVATEFAFRKRLREMEKVYSELKWQEKNTLEE----IAELQEDIRHLEEDLRTK 307
E +AQ R + A K +E E+ + E+ L + AE+++ + E+ LR K
Sbjct: 2100 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2159
Query: 308 LLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDAL- 366
+ E T R +E D + L +E+ +L+A ++ +Q ++ L ++
Sbjct: 2160 ------AQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2212
Query: 367 --CKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAER 403
+ L++L+A I + +++L K +T+R L AE+
Sbjct: 2213 VQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAEK 2250
Score = 33.5 bits (75), Expect = 0.38
Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 23/210 (10%)
Query: 120 RESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVS--QAFEQLCLLQEVQQQLNSDHR 177
++S D + +++ + EL +E E ++ K LQ K Q +Q LLQE Q S
Sbjct: 2417 QQSDHDAERLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2475
Query: 178 GKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAAT 237
K L+ +R + L+Q + E +
Sbjct: 2476 EKDSLLQRERF-------------------IEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2516
Query: 238 ELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
+ E + + E ++ E R++ E++++ + + QE+ EE L+E +
Sbjct: 2517 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2576
Query: 298 RHLEEDLRTKLL-SLKLSHTRLEARTYRPN 326
+ LEE R L S +++ +++ A PN
Sbjct: 2577 QLLEEQHRAALAHSEEVTASQVAATKTLPN 2606
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 51.6 bits (122), Expect = 1e-06
Identities = 98/403 (24%), Positives = 174/403 (43%), Gaps = 56/403 (13%)
Query: 11 RFQLPDWHTNSYLLSTNAQ-LQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERID 69
R QL + LL Q L+ +A+ RQ ++V E ++ + + ++L RI+
Sbjct: 2178 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV---EEELFSVRVQMEELSKLKARIE 2234
Query: 70 TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRE-SRRDIDV 128
NR + DK T + +A +MK+ AE+ A L + A E LR+ + D+
Sbjct: 2235 AENRALILRDKDNTQRFLQEEA-EKMKQVAEE---AARLSV-AAQEAARLRQLAEEDLAQ 2289
Query: 129 VKDPVEDELHKEVEVI-EATK-----KALQQKVSQAFEQLCLLQE----VQQQLNSDHRG 178
+ E L ++++ + EAT+ + LQQ+ A EQ LQE + QQL + +G
Sbjct: 2290 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2349
Query: 179 KMETLEIDR-GCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-AEMKAA 236
TLE +R L ++ + + L+V + +D RF K E E
Sbjct: 2350 FQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2405
Query: 237 TELREATALTIAETNNELEAQRVATEF-------AFRKRLREMEKVYSELKW-------- 281
TEL +T+ +T LE QR ++ A + RE EK+ E K
Sbjct: 2406 TELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2462
Query: 282 ---QEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLE-------ARTYRPNVELCR 331
Q++ L+E LQ+ ++ L + ++ +LE A+ + E R
Sbjct: 2463 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2522
Query: 332 DQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
Q Q + E +L A++ +++ +A++ + + L +L+
Sbjct: 2523 QQQQ--MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2563
Score = 38.9 bits (89), Expect = 0.009
Identities = 82/380 (21%), Positives = 145/380 (38%), Gaps = 46/380 (12%)
Query: 28 AQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDA 87
AQL+R + A+ LR E + R R E + RW+ ++ L L
Sbjct: 1576 AQLERSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALR-LRL 1632
Query: 88 EIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPV------EDELHKEV 141
+ + + Q K A+ + + + RE+RR + V E EL K+
Sbjct: 1633 QAEEVAQQKSLAQAEAEKQKEEAE--------REARRRGKAEEQAVRQRELAEQELEKQR 1684
Query: 142 EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
++ E T QQ+++ E + L E +Q + E + R + + +
Sbjct: 1685 QLAEGTA---QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1741
Query: 202 KVDPTR------VPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELE 255
++ R + + ++ S +K R EAE EL E A A
Sbjct: 1742 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1801
Query: 256 AQRVATEFAFRKRLREMEKVYSE----------LKWQEKNTLEEIAELQEDIRHLEED-- 303
+++A E A R+R E E+V +E LK + + L+E E +R L ED
Sbjct: 1802 QRQLAEEDAARQR-AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1860
Query: 304 LRTKLLSLKLSHTRLEARTYRPNVELCRD---QAQYGLTDEV----HQLEATIAALKQKL 356
+ + L + + + + + D + Q GL ++ Q+E I ALK
Sbjct: 1861 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1920
Query: 357 AQAQDALDALCKHLARLQAD 376
+A L L R++++
Sbjct: 1921 EKAAAGKAELELELGRIRSN 1940
Score = 38.1 bits (87), Expect = 0.016
Identities = 84/399 (21%), Positives = 165/399 (41%), Gaps = 34/399 (8%)
Query: 28 AQLQRDASHQIRQEARVLRNETNNQT--IWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
AQ + D ++ Q + +E Q + D R ++ E I + E +L
Sbjct: 1871 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1930
Query: 86 DAEIDALTQMKESAEQNLQAKN-LPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVI 144
+ E L +++ +AE L++K L+ A + E R ++ V+ L E E
Sbjct: 1931 ELE---LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1987
Query: 145 EATKKALQQ--KVSQAFEQLCLL-----QEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
K AL++ ++ E+ L QE +QL + L+ + + ++
Sbjct: 1988 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2047
Query: 198 NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-----AEMKAATELREATALTIAETNN 252
L+ + L+ + +R + AE AE +AA R+ + +
Sbjct: 2048 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2107
Query: 253 ELEAQ-RVATEFAFRKRLREMEKVYSELKWQEKNTLEE----IAELQEDIRHLEEDLRTK 307
E +AQ R + A K +E E+ + E+ L + AE+++ + E+ LR K
Sbjct: 2108 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2167
Query: 308 LLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDAL- 366
+ E T R +E D + L +E+ +L+A ++ +Q ++ L ++
Sbjct: 2168 ------AQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2220
Query: 367 --CKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAER 403
+ L++L+A I + +++L K +T+R L AE+
Sbjct: 2221 VQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAEK 2258
Score = 33.5 bits (75), Expect = 0.38
Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 23/210 (10%)
Query: 120 RESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVS--QAFEQLCLLQEVQQQLNSDHR 177
++S D + +++ + EL +E E ++ K LQ K Q +Q LLQE Q S
Sbjct: 2425 QQSDHDAERLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2483
Query: 178 GKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAAT 237
K L+ +R + L+Q + E +
Sbjct: 2484 EKDSLLQRERF-------------------IEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2524
Query: 238 ELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
+ E + + E ++ E R++ E++++ + + QE+ EE L+E +
Sbjct: 2525 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2584
Query: 298 RHLEEDLRTKLL-SLKLSHTRLEARTYRPN 326
+ LEE R L S +++ +++ A PN
Sbjct: 2585 QLLEEQHRAALAHSEEVTASQVAATKTLPN 2614
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 51.6 bits (122), Expect = 1e-06
Identities = 98/403 (24%), Positives = 174/403 (43%), Gaps = 56/403 (13%)
Query: 11 RFQLPDWHTNSYLLSTNAQ-LQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERID 69
R QL + LL Q L+ +A+ RQ ++V E ++ + + ++L RI+
Sbjct: 2219 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV---EEELFSVRVQMEELSKLKARIE 2275
Query: 70 TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRE-SRRDIDV 128
NR + DK T + +A +MK+ AE+ A L + A E LR+ + D+
Sbjct: 2276 AENRALILRDKDNTQRFLQEEA-EKMKQVAEE---AARLSV-AAQEAARLRQLAEEDLAQ 2330
Query: 129 VKDPVEDELHKEVEVI-EATK-----KALQQKVSQAFEQLCLLQE----VQQQLNSDHRG 178
+ E L ++++ + EAT+ + LQQ+ A EQ LQE + QQL + +G
Sbjct: 2331 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2390
Query: 179 KMETLEIDR-GCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-AEMKAA 236
TLE +R L ++ + + L+V + +D RF K E E
Sbjct: 2391 FQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2446
Query: 237 TELREATALTIAETNNELEAQRVATEF-------AFRKRLREMEKVYSELKW-------- 281
TEL +T+ +T LE QR ++ A + RE EK+ E K
Sbjct: 2447 TELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2503
Query: 282 ---QEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLE-------ARTYRPNVELCR 331
Q++ L+E LQ+ ++ L + ++ +LE A+ + E R
Sbjct: 2504 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2563
Query: 332 DQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
Q Q + E +L A++ +++ +A++ + + L +L+
Sbjct: 2564 QQQQ--MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2604
Score = 38.9 bits (89), Expect = 0.009
Identities = 82/380 (21%), Positives = 145/380 (38%), Gaps = 46/380 (12%)
Query: 28 AQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDA 87
AQL+R + A+ LR E + R R E + RW+ ++ L L
Sbjct: 1617 AQLERSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALR-LRL 1673
Query: 88 EIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPV------EDELHKEV 141
+ + + Q K A+ + + + RE+RR + V E EL K+
Sbjct: 1674 QAEEVAQQKSLAQAEAEKQKEEAE--------REARRRGKAEEQAVRQRELAEQELEKQR 1725
Query: 142 EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
++ E T QQ+++ E + L E +Q + E + R + + +
Sbjct: 1726 QLAEGTA---QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1782
Query: 202 KVDPTR------VPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELE 255
++ R + + ++ S +K R EAE EL E A A
Sbjct: 1783 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1842
Query: 256 AQRVATEFAFRKRLREMEKVYSE----------LKWQEKNTLEEIAELQEDIRHLEED-- 303
+++A E A R+R E E+V +E LK + + L+E E +R L ED
Sbjct: 1843 QRQLAEEDAARQR-AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901
Query: 304 LRTKLLSLKLSHTRLEARTYRPNVELCRD---QAQYGLTDEV----HQLEATIAALKQKL 356
+ + L + + + + + D + Q GL ++ Q+E I ALK
Sbjct: 1902 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1961
Query: 357 AQAQDALDALCKHLARLQAD 376
+A L L R++++
Sbjct: 1962 EKAAAGKAELELELGRIRSN 1981
Score = 38.1 bits (87), Expect = 0.016
Identities = 84/399 (21%), Positives = 165/399 (41%), Gaps = 34/399 (8%)
Query: 28 AQLQRDASHQIRQEARVLRNETNNQT--IWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
AQ + D ++ Q + +E Q + D R ++ E I + E +L
Sbjct: 1912 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1971
Query: 86 DAEIDALTQMKESAEQNLQAKN-LPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVI 144
+ E L +++ +AE L++K L+ A + E R ++ V+ L E E
Sbjct: 1972 ELE---LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2028
Query: 145 EATKKALQQ--KVSQAFEQLCLL-----QEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
K AL++ ++ E+ L QE +QL + L+ + + ++
Sbjct: 2029 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2088
Query: 198 NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-----AEMKAATELREATALTIAETNN 252
L+ + L+ + +R + AE AE +AA R+ + +
Sbjct: 2089 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2148
Query: 253 ELEAQ-RVATEFAFRKRLREMEKVYSELKWQEKNTLEE----IAELQEDIRHLEEDLRTK 307
E +AQ R + A K +E E+ + E+ L + AE+++ + E+ LR K
Sbjct: 2149 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2208
Query: 308 LLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDAL- 366
+ E T R +E D + L +E+ +L+A ++ +Q ++ L ++
Sbjct: 2209 ------AQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2261
Query: 367 --CKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAER 403
+ L++L+A I + +++L K +T+R L AE+
Sbjct: 2262 VQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAEK 2299
Score = 33.5 bits (75), Expect = 0.38
Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 23/210 (10%)
Query: 120 RESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVS--QAFEQLCLLQEVQQQLNSDHR 177
++S D + +++ + EL +E E ++ K LQ K Q +Q LLQE Q S
Sbjct: 2466 QQSDHDAERLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2524
Query: 178 GKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAAT 237
K L+ +R + L+Q + E +
Sbjct: 2525 EKDSLLQRERF-------------------IEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2565
Query: 238 ELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
+ E + + E ++ E R++ E++++ + + QE+ EE L+E +
Sbjct: 2566 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2625
Query: 298 RHLEEDLRTKLL-SLKLSHTRLEARTYRPN 326
+ LEE R L S +++ +++ A PN
Sbjct: 2626 QLLEEQHRAALAHSEEVTASQVAATKTLPN 2655
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/370 (20%), Positives = 167/370 (45%), Gaps = 33/370 (8%)
Query: 57 EHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIEC 116
E DN ER D + + K L+ + +++ ++ +E L AK L+ EC
Sbjct: 896 EQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLED----EEEMNAELTAKKRKLED--EC 949
Query: 117 LTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDH 176
L++ D+++ VE E H E K L ++++ E + L + ++ L H
Sbjct: 950 SELKKDIDDLELTLAKVEKEKH----ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1005
Query: 177 RGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAA 236
+ ++ L+++ ++ +L + L+ +V D +L+Q + R + +RA+ +++
Sbjct: 1006 QQALDDLQVEEDKVN-SLSKSKVKLE---QQVDDLEGSLEQ-EKKVRMDLERAKRKLEGD 1060
Query: 237 TELREATALTIAETNNELEAQRVATEFAFRK---RLREMEKVYSELKWQEKNTLEEIAEL 293
+L + + + + +LE + EF + ++ + + + +L+ + K I EL
Sbjct: 1061 LKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEEL 1120
Query: 294 QEDI------RHLEEDLRTKLL-SLKLSHTRLEARTYRPNVEL---CRDQAQY-----GL 338
+E++ R E LR+ L L+ RLE +V++ + +A++ L
Sbjct: 1121 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 1180
Query: 339 TDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKANSMLLDTKCMDTRRKLT 398
+ Q EAT AAL++K A + L +L R++ + + + L+ + + +
Sbjct: 1181 EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQI 1240
Query: 399 VPAERFVPEV 408
+ A+ + +V
Sbjct: 1241 IKAKANLEKV 1250
Score = 47.0 bits (110), Expect = 3e-05
Identities = 68/341 (19%), Positives = 140/341 (41%), Gaps = 42/341 (12%)
Query: 41 EARVLRNETNNQTIWDEH-DNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESA 99
E L++E + +H D+ L E+ID + R K+ L+K ++ E+D +T +
Sbjct: 1181 EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVT---SNM 1237
Query: 100 EQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAF 159
EQ ++AK +++ V +ED+ ++ +E +++L +Q
Sbjct: 1238 EQIIKAK-----------------ANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRA 1280
Query: 160 EQLCLLQEVQQQLNSDHRGKMETL--EIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQ 217
+ E+ +QL + E L ++ RG LS + ++ +++ L
Sbjct: 1281 KLQTENGELARQLE-----EKEALISQLTRGKLSYTQQMEDLKRQLE--EEGKAKNALAH 1333
Query: 218 WDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYS 277
+R + D + + TE + +++ N+E+ R E +R E+E+
Sbjct: 1334 ALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKK 1393
Query: 278 ELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYG 337
+L A+ +D E + K SL+ + RL+ V++ R A
Sbjct: 1394 KL-----------AQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA 1442
Query: 338 LTDEVHQ-LEATIAALKQKLAQAQDALDALCKHLARLQADI 377
D+ + + +A KQK ++Q L++ K L ++
Sbjct: 1443 ALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1483
Score = 44.3 bits (103), Expect = 2e-04
Identities = 74/381 (19%), Positives = 158/381 (41%), Gaps = 40/381 (10%)
Query: 7 KPSRRFQLPDWHTN-SYLLSTNAQLQRDASHQIRQEARVLRN--ETNNQTIWDEHDNRTR 63
K + +L D +N ++ A L++ S + +A R E +++ D R +
Sbjct: 1223 KSEFKLELDDVTSNMEQIIKAKANLEK-VSRTLEDQANEYRVKLEEAQRSLNDFTTQRAK 1281
Query: 64 LVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESR 123
L + R E + ++ L + TQ E ++ L+ + + L + +R
Sbjct: 1282 LQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHAL--QSAR 1339
Query: 124 RDIDVVKDPVEDELHKEVEVIEATKKALQQKV-------SQAFEQLCLLQEVQQQLNSDH 176
D D++++ E+E + E+ KA + + A ++ L+E +++L
Sbjct: 1340 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1399
Query: 177 RGKMETLE-IDRGCLSLNLRSPNISLKVDPTRVP-DGSTTLQQWDDFSRFNKDRAEAEMK 234
+ E +E ++ C SL + +++ V + S D + N D+ AE K
Sbjct: 1400 QDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWK 1459
Query: 235 AATELREATALTIAETNNELEAQRVATE-FAFRKRLREMEKVYSELKWQEKNTLEEIAEL 293
E ++ +++ EA+ ++TE F + E + K + KN EEI++L
Sbjct: 1460 QKYEESQSEL-----ESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDL 1514
Query: 294 QE----------DIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVH 343
E ++ + + L + L L+ + EA ++ R Q ++ +
Sbjct: 1515 TEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEF------N 1568
Query: 344 QLEATIAALKQKLAQAQDALD 364
Q++A I ++KLA+ + ++
Sbjct: 1569 QIKAEI---ERKLAEKDEEME 1586
Score = 43.1 bits (100), Expect = 5e-04
Identities = 68/335 (20%), Positives = 141/335 (42%), Gaps = 28/335 (8%)
Query: 64 LVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESR 123
L E ++ + ++K +DL E++ +++ E A V IE RE+
Sbjct: 1120 LEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGG-------ATSVQIEMNKKREA- 1171
Query: 124 RDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKME-T 182
+ ++ +E+ + A +K V++ EQ+ LQ V+Q+L + K E
Sbjct: 1172 -EFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE---KSEFK 1227
Query: 183 LEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREA 242
LE+D ++ N+ I K + +V S TL+ + R + A+ + T R
Sbjct: 1228 LELDD--VTSNMEQI-IKAKANLEKV---SRTLEDQANEYRVKLEEAQRSLNDFTTQRAK 1281
Query: 243 TALTIAETNNELEAQRVATEFAFRKRL---REMEKVYSELKWQEKNTLEEIAELQEDIRH 299
E +LE + R +L ++ME + +L+ +E +A + RH
Sbjct: 1282 LQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLE-EEGKAKNALAHALQSARH 1340
Query: 300 LEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGL-----TDEVHQLEATIAALKQ 354
+ LR + + L+ + N E+ + + +Y T+E+ + + +A Q
Sbjct: 1341 DCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1400
Query: 355 KLAQAQDALDALCKHLARLQADIACKANSMLLDTK 389
+A +A++A C L + + + + +++D +
Sbjct: 1401 DAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE 1435
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 49.7 bits (117), Expect = 5e-06
Identities = 90/414 (21%), Positives = 175/414 (42%), Gaps = 58/414 (14%)
Query: 31 QRDASHQIRQEARVLRNETNN--QTIWDEHDNRTRL-VERIDTVNRWKEMLDKCLTDLDA 87
+ D Q++ E + + + + + + +E R +L +E++ + K++ D+ L +D
Sbjct: 934 EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDD 992
Query: 88 EIDALTQMKESAEQNLQAKNLPLDVAIE---CLTLRESRRDIDVVKDPVEDELHKEV--- 141
+ + L++ ++ E+ + +L ++A E L + + + + +E L KE
Sbjct: 993 QNNKLSKERKLLEERIS--DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1050
Query: 142 EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
+ +E K+ L+ S EQ+ LQ +L K E L+ L + N +L
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110
Query: 202 KVDPTRVPDGSTT-LQQWDDFSRFNKDRAEAEMKAATELREATALTIAET------NNEL 254
K R +G + LQ+ D R +++AE + + E EA + +T EL
Sbjct: 1111 K--KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168
Query: 255 EAQRVATEFAFRKRL----REMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLS 310
A+R +K L R E E++ + +EE+ E E + + +L +
Sbjct: 1169 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1228
Query: 311 LK------------LSHTRLEARTYRPNVEL--------CRD--QAQYGLTDEVHQLEAT 348
L+ L + E + +E C D +A+ L D+VH+L+
Sbjct: 1229 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1288
Query: 349 IAALKQKLAQAQDALDALCKHLARLQADIACKANSMLLDTKCM---DTRRKLTV 399
+ ++ L +A+ L K +A L +S L DT+ + +TR+KL V
Sbjct: 1289 VESVTGMLNEAEGKAIKLAKDVASL--------SSQLQDTQELLQEETRQKLNV 1334
Score = 46.2 bits (108), Expect = 6e-05
Identities = 67/304 (22%), Positives = 132/304 (43%), Gaps = 30/304 (9%)
Query: 69 DTVNRWKEMLDKC---LTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIEC-LTLRESRR 124
D + + KE K L +L+ + LT+ K ++ LQA+ A E + L ++
Sbjct: 859 DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 918
Query: 125 DIDVVKDPVEDELHKEVE---VIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDH---RG 178
+++ + +E L +E + ++A +K + Q++ EQL + +Q+L +
Sbjct: 919 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEA 978
Query: 179 KMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATE 238
K++ LE + + + K+ R+ D +T L + E + K T+
Sbjct: 979 KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-----------EEEKAKNLTK 1027
Query: 239 LREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIR 298
L+ I+E L+ + K +E+EK+ +L+ + E+IA+LQ I
Sbjct: 1028 LKNKHESMISELEVRLKKEE--------KSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 299 HLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYG-LTDEVHQLEATIAALKQKLA 357
L+ L K L+ + RL+ + N L + + G ++D L++ AA +
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139
Query: 358 QAQD 361
Q +D
Sbjct: 1140 QKRD 1143
Score = 41.6 bits (96), Expect = 0.001
Identities = 68/365 (18%), Positives = 146/365 (40%), Gaps = 31/365 (8%)
Query: 20 NSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDN----RTRLVERIDTVNRWK 75
+S L T LQ + ++ ++ + E ++ D+ D + L I T+N
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1373
Query: 76 EMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVED 135
K L D + ++AL + K+ ++ ++ NL + + ++ K+ ++
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEIE--NLTQQYEEKAAAYDK----LEKTKNRLQQ 1427
Query: 136 ELHKEVEVIEATKKALQ--QKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLN 193
EL V ++ ++ + +K + F+QL ++ +D R + E ++ +L+
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487
Query: 194 LRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNE 253
L L+ ++ R NK +AEM+ ++ + + +E
Sbjct: 1488 LARAL-------------EEALEAKEELERTNK-MLKAEMEDLVSSKD----DVGKNVHE 1529
Query: 254 LEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKL 313
LE + A E + ++E++ EL+ E L +Q E DL+ + +
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1589
Query: 314 SHTRLEARTYRPNVELCRDQAQYGLTDEV-HQLEATIAALKQKLAQAQDALDALCKHLAR 372
+L+ + + EL ++ Q L +LE + L+ + A + K L +
Sbjct: 1590 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK 1649
Query: 373 LQADI 377
LQA +
Sbjct: 1650 LQAQM 1654
Score = 38.1 bits (87), Expect = 0.016
Identities = 69/338 (20%), Positives = 140/338 (41%), Gaps = 59/338 (17%)
Query: 64 LVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKN---LPLDVAIECLT-- 118
LV D V + L+K L+ +++ + E E LQA L L+V ++ L
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575
Query: 119 ---------------LRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLC 163
R+ +R + + +EDE K+ + A KK L+
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDE-RKQRALAAAAKKKLEGD--------- 1625
Query: 164 LLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSR 223
L++++ Q +S +G+ E ++ LR +K + D + + ++
Sbjct: 1626 -LKDLELQADSAIKGREEAIK--------QLRKLQAQMKDFQRELEDARASRDEIFATAK 1676
Query: 224 FNKDRAEAEMKAATELREATALTI-----AETNNELEAQRVATEFAFRKRLREMEKVYSE 278
N+ +A++ +L+E A A+ E A+ +A+ + R L++ ++
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR---R 1733
Query: 279 LKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLK-LSHTRLEARTYRPNVELCRDQAQYG 337
L+ + EE+ E Q ++ + + +R + LS+ R+ E R Q +
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1793
Query: 338 ---LTDEVHQLE--------ATIAALKQKLAQAQDALD 364
L ++H++E +TIAAL+ K+AQ ++ ++
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1831
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 49.7 bits (117), Expect = 5e-06
Identities = 90/414 (21%), Positives = 175/414 (42%), Gaps = 58/414 (14%)
Query: 31 QRDASHQIRQEARVLRNETNN--QTIWDEHDNRTRL-VERIDTVNRWKEMLDKCLTDLDA 87
+ D Q++ E + + + + + + +E R +L +E++ + K++ D+ L +D
Sbjct: 941 EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDD 999
Query: 88 EIDALTQMKESAEQNLQAKNLPLDVAIE---CLTLRESRRDIDVVKDPVEDELHKEV--- 141
+ + L++ ++ E+ + +L ++A E L + + + + +E L KE
Sbjct: 1000 QNNKLSKERKLLEERIS--DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1057
Query: 142 EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
+ +E K+ L+ S EQ+ LQ +L K E L+ L + N +L
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117
Query: 202 KVDPTRVPDGSTT-LQQWDDFSRFNKDRAEAEMKAATELREATALTIAET------NNEL 254
K R +G + LQ+ D R +++AE + + E EA + +T EL
Sbjct: 1118 K--KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1175
Query: 255 EAQRVATEFAFRKRL----REMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLS 310
A+R +K L R E E++ + +EE+ E E + + +L +
Sbjct: 1176 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1235
Query: 311 LK------------LSHTRLEARTYRPNVEL--------CRD--QAQYGLTDEVHQLEAT 348
L+ L + E + +E C D +A+ L D+VH+L+
Sbjct: 1236 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1295
Query: 349 IAALKQKLAQAQDALDALCKHLARLQADIACKANSMLLDTKCM---DTRRKLTV 399
+ ++ L +A+ L K +A L +S L DT+ + +TR+KL V
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASL--------SSQLQDTQELLQEETRQKLNV 1341
Score = 46.2 bits (108), Expect = 6e-05
Identities = 67/304 (22%), Positives = 132/304 (43%), Gaps = 30/304 (9%)
Query: 69 DTVNRWKEMLDKC---LTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIEC-LTLRESRR 124
D + + KE K L +L+ + LT+ K ++ LQA+ A E + L ++
Sbjct: 866 DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 925
Query: 125 DIDVVKDPVEDELHKEVE---VIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDH---RG 178
+++ + +E L +E + ++A +K + Q++ EQL + +Q+L +
Sbjct: 926 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEA 985
Query: 179 KMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATE 238
K++ LE + + + K+ R+ D +T L + E + K T+
Sbjct: 986 KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-----------EEEKAKNLTK 1034
Query: 239 LREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIR 298
L+ I+E L+ + K +E+EK+ +L+ + E+IA+LQ I
Sbjct: 1035 LKNKHESMISELEVRLKKEE--------KSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 299 HLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYG-LTDEVHQLEATIAALKQKLA 357
L+ L K L+ + RL+ + N L + + G ++D L++ AA +
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146
Query: 358 QAQD 361
Q +D
Sbjct: 1147 QKRD 1150
Score = 41.6 bits (96), Expect = 0.001
Identities = 68/365 (18%), Positives = 146/365 (40%), Gaps = 31/365 (8%)
Query: 20 NSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDN----RTRLVERIDTVNRWK 75
+S L T LQ + ++ ++ + E ++ D+ D + L I T+N
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1380
Query: 76 EMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVED 135
K L D + ++AL + K+ ++ ++ NL + + ++ K+ ++
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEIE--NLTQQYEEKAAAYDK----LEKTKNRLQQ 1434
Query: 136 ELHKEVEVIEATKKALQ--QKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLN 193
EL V ++ ++ + +K + F+QL ++ +D R + E ++ +L+
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494
Query: 194 LRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNE 253
L L+ ++ R NK +AEM+ ++ + + +E
Sbjct: 1495 LARAL-------------EEALEAKEELERTNK-MLKAEMEDLVSSKD----DVGKNVHE 1536
Query: 254 LEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKL 313
LE + A E + ++E++ EL+ E L +Q E DL+ + +
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596
Query: 314 SHTRLEARTYRPNVELCRDQAQYGLTDEV-HQLEATIAALKQKLAQAQDALDALCKHLAR 372
+L+ + + EL ++ Q L +LE + L+ + A + K L +
Sbjct: 1597 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK 1656
Query: 373 LQADI 377
LQA +
Sbjct: 1657 LQAQM 1661
Score = 38.1 bits (87), Expect = 0.016
Identities = 69/338 (20%), Positives = 140/338 (41%), Gaps = 59/338 (17%)
Query: 64 LVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKN---LPLDVAIECLT-- 118
LV D V + L+K L+ +++ + E E LQA L L+V ++ L
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582
Query: 119 ---------------LRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLC 163
R+ +R + + +EDE K+ + A KK L+
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDE-RKQRALAAAAKKKLEGD--------- 1632
Query: 164 LLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSR 223
L++++ Q +S +G+ E ++ LR +K + D + + ++
Sbjct: 1633 -LKDLELQADSAIKGREEAIK--------QLRKLQAQMKDFQRELEDARASRDEIFATAK 1683
Query: 224 FNKDRAEAEMKAATELREATALTI-----AETNNELEAQRVATEFAFRKRLREMEKVYSE 278
N+ +A++ +L+E A A+ E A+ +A+ + R L++ ++
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR---R 1740
Query: 279 LKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLK-LSHTRLEARTYRPNVELCRDQAQYG 337
L+ + EE+ E Q ++ + + +R + LS+ R+ E R Q +
Sbjct: 1741 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1800
Query: 338 ---LTDEVHQLE--------ATIAALKQKLAQAQDALD 364
L ++H++E +TIAAL+ K+AQ ++ ++
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1838
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.128 0.356
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,177,257
Number of Sequences: 37866
Number of extensions: 580861
Number of successful extensions: 4684
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 502
Number of HSP's that attempted gapping in prelim test: 3440
Number of HSP's gapped (non-prelim): 1428
length of query: 430
length of database: 18,247,518
effective HSP length: 105
effective length of query: 325
effective length of database: 14,271,588
effective search space: 4638266100
effective search space used: 4638266100
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.