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Search of human proteins with 157671919
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157671919 hypothetical protein LOC374864 isoform 1 [Homo
sapiens]
(867 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157671919 hypothetical protein LOC374864 isoform 1 [Homo sapi... 1706 0.0
gi|157671917 hypothetical protein LOC374864 isoform 2 [Homo sapi... 1616 0.0
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 94 7e-19
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 92 3e-18
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 92 3e-18
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 90 8e-18
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 90 1e-17
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 90 1e-17
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 88 3e-17
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 88 3e-17
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 88 4e-17
gi|156104908 myosin heavy chain 6 [Homo sapiens] 88 4e-17
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 87 9e-17
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 86 1e-16
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho... 85 3e-16
gi|71061468 centromere protein E [Homo sapiens] 85 3e-16
gi|21735548 centrosomal protein 2 [Homo sapiens] 84 4e-16
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 84 6e-16
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 83 1e-15
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 83 1e-15
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 82 2e-15
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 82 2e-15
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 82 2e-15
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 82 2e-15
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 82 3e-15
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 82 3e-15
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 81 4e-15
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 81 4e-15
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 81 5e-15
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 81 5e-15
>gi|157671919 hypothetical protein LOC374864 isoform 1 [Homo
sapiens]
Length = 867
Score = 1706 bits (4418), Expect = 0.0
Identities = 867/867 (100%), Positives = 867/867 (100%)
Query: 1 MTENKTVSSSSTRDDQTNIGLTCQEVKALREKAWSRTNEGNAMSQSLVLYGASKENSEGF 60
MTENKTVSSSSTRDDQTNIGLTCQEVKALREKAWSRTNEGNAMSQSLVLYGASKENSEGF
Sbjct: 1 MTENKTVSSSSTRDDQTNIGLTCQEVKALREKAWSRTNEGNAMSQSLVLYGASKENSEGF 60
Query: 61 HESKMTNTEGVNKGIYFSYPCRRHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETS 120
HESKMTNTEGVNKGIYFSYPCRRHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETS
Sbjct: 61 HESKMTNTEGVNKGIYFSYPCRRHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETS 120
Query: 121 FEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETD 180
FEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETD
Sbjct: 121 FEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETD 180
Query: 181 RADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKAN 240
RADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKAN
Sbjct: 181 RADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKAN 240
Query: 241 QLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRK 300
QLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRK
Sbjct: 241 QLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRK 300
Query: 301 VNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVIN 360
VNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVIN
Sbjct: 301 VNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVIN 360
Query: 361 VNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVND 420
VNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVND
Sbjct: 361 VNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVND 420
Query: 421 FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESE 480
FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESE
Sbjct: 421 FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESE 480
Query: 481 IKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKL 540
IKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKL
Sbjct: 481 IKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKL 540
Query: 541 TQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSL 600
TQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSL
Sbjct: 541 TQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSL 600
Query: 601 DKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSK 660
DKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSK
Sbjct: 601 DKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSK 660
Query: 661 TMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDC 720
TMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDC
Sbjct: 661 TMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDC 720
Query: 721 EERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNI 780
EERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNI
Sbjct: 721 EERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNI 780
Query: 781 YDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAV 840
YDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAV
Sbjct: 781 YDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAV 840
Query: 841 QEESSNLMQHILGFFQTLTDGTCENDG 867
QEESSNLMQHILGFFQTLTDGTCENDG
Sbjct: 841 QEESSNLMQHILGFFQTLTDGTCENDG 867
>gi|157671917 hypothetical protein LOC374864 isoform 2 [Homo
sapiens]
Length = 829
Score = 1616 bits (4184), Expect = 0.0
Identities = 829/867 (95%), Positives = 829/867 (95%), Gaps = 38/867 (4%)
Query: 1 MTENKTVSSSSTRDDQTNIGLTCQEVKALREKAWSRTNEGNAMSQSLVLYGASKENSEGF 60
MTENKTVSSSSTRDDQTNIGLTCQEVKALREKAWSRTNEGNAMSQSLVLYGASKENSEGF
Sbjct: 1 MTENKTVSSSSTRDDQTNIGLTCQEVKALREKAWSRTNEGNAMSQSLVLYGASKENSEGF 60
Query: 61 HESKMTNTEGVNKGIYFSYPCRRHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETS 120
HESKMTNTEGVNKGIYFSYPCRRHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETS
Sbjct: 61 HESKMTNTEGVNKGIYFSYPCRRHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETS 120
Query: 121 FEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETD 180
FEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETD
Sbjct: 121 FEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETD 180
Query: 181 RADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKAN 240
RADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKAN
Sbjct: 181 RADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKAN 240
Query: 241 QLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRK 300
QLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRK
Sbjct: 241 QLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRK 300
Query: 301 VNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVIN 360
VNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVIN
Sbjct: 301 VNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVIN 360
Query: 361 VNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVND 420
VNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVND
Sbjct: 361 VNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVND 420
Query: 421 FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESE 480
FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESE
Sbjct: 421 FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESE 480
Query: 481 IKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKL 540
IKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKL
Sbjct: 481 IKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKL 540
Query: 541 TQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSL 600
TQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSL
Sbjct: 541 TQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSL 600
Query: 601 DKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSK 660
DKEHSV SKRSAIFKDLEATKSK
Sbjct: 601 DKEHSV--------------------------------------SKRSAIFKDLEATKSK 622
Query: 661 TMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDC 720
TMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDC
Sbjct: 623 TMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDC 682
Query: 721 EERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNI 780
EERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNI
Sbjct: 683 EERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNI 742
Query: 781 YDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAV 840
YDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAV
Sbjct: 743 YDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAV 802
Query: 841 QEESSNLMQHILGFFQTLTDGTCENDG 867
QEESSNLMQHILGFFQTLTDGTCENDG
Sbjct: 803 QEESSNLMQHILGFFQTLTDGTCENDG 829
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 93.6 bits (231), Expect = 7e-19
Identities = 151/687 (21%), Positives = 294/687 (42%), Gaps = 98/687 (14%)
Query: 175 KSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWH 234
+ L+ + E L + S+ KI W V EL K E +IE Q
Sbjct: 89 EGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQEN--RKIIEAQ-- 144
Query: 235 LEDKANQLQHF--EKQKTELEEANAKIQADIDYMNEHGP------LLDSKQNQELQDLKN 286
KA Q F EK +LEE IQ + D + E+ LL + + K
Sbjct: 145 --RKAIQELQFGNEKVSLKLEEG---IQENKDLIKENNATRHLCNLLKETCARSAEKTKK 199
Query: 287 HYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIY- 345
+ ++ E ++ +N +E+ + A E R++A+ + E+ + +D + I+ ++E
Sbjct: 200 YEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKK 259
Query: 346 QLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNEL------------------H 387
++N S +I + T E K +++T + E++ N+L H
Sbjct: 260 EINDKEKQVSLLLIQI-TEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQH 318
Query: 388 SLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACT 447
L+K LED++ + QK+ E A + + ++ + K +A S T
Sbjct: 319 HLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVT 378
Query: 448 K-----------LTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLK 496
+ L + ++LE + +++ + T E ++KKS SE++ +T + + L+
Sbjct: 379 EFETTVCSLEELLRTEQQRLEKNEDQLKILTME-LQKKS---SELEEMTKLTNNKEVELE 434
Query: 497 NIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQG--------EVAAG 548
+ K TL + K +KIAE + KG E+ L L Q E+
Sbjct: 435 ELKKVLGEKETLLYENK-----QFEKIAE---ELKGTEQELIGLLQAREKEVHDLEIQLT 486
Query: 549 MVLQKKLYSIYEVQALE---RKELIKNRAICA----MSL------AELQEPLLQLEDEAE 595
+ + Y EV+ L+ E +KN + + +SL E + L+L+++ E
Sbjct: 487 AITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQE 546
Query: 596 RIRSLDKEHSVML---NNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFK 652
I + K+ ML N+ + + +R ++ V+++L++K + L ++E + + K
Sbjct: 547 DINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRK 606
Query: 653 DLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVF-- 710
+E K+K I EL +E KA +++ + + L + + K + + E A+ F
Sbjct: 607 QVE-NKNK------YIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGE 659
Query: 711 --DHYMQE---KKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQ 765
D Y +E KK EE + EE ++ +V+ K ++ K + E + L ++++
Sbjct: 660 ITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKH 719
Query: 766 LQITFLKEKDNYFNIYDKQLSLDTSIR 792
++E+D+ +Y + +S+R
Sbjct: 720 QYDKIIEERDSELGLYKSKEQEQSSLR 746
Score = 47.4 bits (111), Expect = 6e-05
Identities = 81/405 (20%), Positives = 171/405 (42%), Gaps = 61/405 (15%)
Query: 114 LKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKP--GEKR-----DEKCPELKQEMETL 166
L++ + EE ++ ++ K+++ ++E+K GEK +++ ++ +E++
Sbjct: 412 LQKKSSELEEMTKLTNNKEVE--------LEELKKVLGEKETLLYENKQFEKIAEELKGT 463
Query: 167 LSEAIRLIKSLETDRADAEEAL-----KQQRSRKNMINMKIDSWSVWKLQELPLAVQ--- 218
E I L+++ E + D E L +Q K + ++K + + KL+ L
Sbjct: 464 EQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENE-KLKNTELTSHCNK 522
Query: 219 -----KEHEAYLSDV-IELQWHLEDKANQLQHFE---KQKTELEEANAKIQADIDYMNEH 269
KE SD+ +EL+ ED N + E KQ L+E +++ +++Y+ E
Sbjct: 523 LSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREE 582
Query: 270 GPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKD 329
+ +L + + + ++ K EEL++ EN LK + E +
Sbjct: 583 LKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQ-----ENKALKKKGTAESKQLN 637
Query: 330 IYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEK---EEEVTEAIRETKSSKNEL 386
+Y+ I+ K E+ +L S + IE+K EE + E + + K +E
Sbjct: 638 VYE----IKVNKLEL-ELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEA 692
Query: 387 HSLSK---------------MLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIE 431
L K ++E + YD++ ++ S Y + + + + +IE
Sbjct: 693 VKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIE 752
Query: 432 LSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSK 476
LS++ + ++ E+ +KL+ + + T E KK++
Sbjct: 753 LSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQ 797
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 91.7 bits (226), Expect = 3e-18
Identities = 162/851 (19%), Positives = 339/851 (39%), Gaps = 118/851 (13%)
Query: 105 DVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVK----------EVKPGEKRDE 154
+ E ++ + FE + EE ++T + + E+ VT + E +E
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEE 907
Query: 155 KCPEL---KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQ 211
+C +L K ++E + E ++ + + +AE K+++ +K D +
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTE--RAEDEEEINAELTAKKRKLEDECSELKKDIDDL---- 961
Query: 212 ELPLA-VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHG 270
EL LA V+KE A + V L + + K+K L+EA+ + D+ +
Sbjct: 962 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV 1021
Query: 271 PLLDS---KQNQELQDLKNHYKKKMEV-MDLHRKVNEELEEALEACENARLKAQQIKEEI 326
L K Q++ DL+ +++ ++ MDL R +LE L+ + + + + K+++
Sbjct: 1022 NTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLER-AKRKLEGDLKLAQESTMDIENDKQQL 1080
Query: 327 DKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEV-------TEAIRET 379
D+ + + E + + +I +L + + IEE EEE+ +A ++
Sbjct: 1081 DEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1140
Query: 380 KSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAA-----------KKTW 428
EL +S+ LE+ K E ++ + D A +K
Sbjct: 1141 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH 1200
Query: 429 DIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIK----YL 484
++++ + + KL ++ +++++I+ + + K E + L
Sbjct: 1201 ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQL 1260
Query: 485 TIMKLKNDKH---LKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRR---KFKGREEFLK 538
+ +K K ++ + ++ + R+ T + DE + ++++ R F + E LK
Sbjct: 1261 SEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELK 1320
Query: 539 KLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDE----- 593
+ + E+ A L L S L R++ + + + AELQ + + E
Sbjct: 1321 RQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQE----AKAELQRAMSKANSEVAQWR 1376
Query: 594 ----------AERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIET 643
E + K+ + L + + + + K ++K ++ + D +I+
Sbjct: 1377 TKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDV 1436
Query: 644 ESKRSAIFKDLEATKSKTMI---FYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMR 700
E +A + ++ I + K E + EL+A ++E +S L +KN +
Sbjct: 1437 ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESL 1496
Query: 701 FKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEEN---- 756
+ E + + QE D E+I E +R L ++++ Q+ ++ A +LEE
Sbjct: 1497 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQA-ALEEAEASL 1555
Query: 757 -------LRLAQEYQQLQITF---LKEKD--------NYFNIYDK-QLSLDTSIRDKKQL 797
LR+ E Q++ + EKD N+ I + Q +LD IR +
Sbjct: 1556 EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDA 1615
Query: 798 CQLQRRMH------TLWQEHFKLVVLFSQMRLANFQT-------------DSQESIQKIL 838
+L+++M + H + + N Q SQE +++ L
Sbjct: 1616 IRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQL 1675
Query: 839 AVQEESSNLMQ 849
A+ E +NL+Q
Sbjct: 1676 AMVERRANLLQ 1686
Score = 65.1 bits (157), Expect = 3e-10
Identities = 129/641 (20%), Positives = 261/641 (40%), Gaps = 87/641 (13%)
Query: 83 RHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETSFEEWS--RTSSTKDLKEDWSVT 140
RH C ++ + + +Q SK + ++ T +E + RT ++ K+ +
Sbjct: 1341 RHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1400
Query: 141 TPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINM 200
E + E + KC L++ + L +E L+ +E A K+QR+ ++
Sbjct: 1401 LQDAE-EHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKIL-- 1457
Query: 201 KIDSWSVWKLQ------ELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEE 254
+ WK + EL A QKE + +++ +++ E+ +QL+ +++ L++
Sbjct: 1458 -----AEWKQKCEETHAELE-ASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQ 1511
Query: 255 ANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACEN 314
+ + I E G K+ EL+ +K +++ + + EE E +LE E
Sbjct: 1512 EISDLTEQIA---EGG-----KRIHELEKIKKQVEQEKSEL---QAALEEAEASLEHEEG 1560
Query: 315 ARLKAQ----QIKEEIDKDIYQDEKTIEAYKRE----IYQLNSLFD---HYSSSVINVNT 363
L+ Q Q+K E+D+ I + ++ I+ KR + + S D + I +
Sbjct: 1561 KILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1620
Query: 364 NIEEKEEEV-----------TEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHEN 412
+E E+ EA+R ++++ L L+D R + L + E
Sbjct: 1621 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVER 1680
Query: 413 Q--YLEA--------VNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINK 462
+ L+A + ++K + EL D ++ + T L KKLE DI++
Sbjct: 1681 RANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ 1740
Query: 463 ITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDK 522
I + + I++ E + K + LK KE T HL + K + +E
Sbjct: 1741 IQGEMEDIIQEARNAEEKAKKAITDAAMMAEELK---KEQ---DTSAHLERMKKN-LEQT 1793
Query: 523 IAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAE 582
+ +++ + E+ K + ++ QK + E++ E +N
Sbjct: 1794 VKDLQHRLDEAEQLALKGGKKQI------QKLEARVRELEGEVESEQKRN---------- 1837
Query: 583 LQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIE 642
E + L +++ L + NI+ +DL+ + KVK R+ + + +
Sbjct: 1838 -VEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVN 1896
Query: 643 TESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKK 683
SK I +LE + + I +++N+L +K++E K
Sbjct: 1897 L-SKFRRIQHELEEAEERADIAESQVNKL--RVKSREVHTK 1934
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 91.7 bits (226), Expect = 3e-18
Identities = 163/850 (19%), Positives = 340/850 (40%), Gaps = 116/850 (13%)
Query: 105 DVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVK----------EVKPGEKRDE 154
+ E ++ + FE + EE ++T + + E+ VT + E +E
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEE 907
Query: 155 KCPEL---KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQ 211
+C +L K ++E + E ++ + + +AE K+++ +K D +
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTE--RAEDEEEINAELTAKKRKLEDECSELKKDIDDL---- 961
Query: 212 ELPLA-VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHG 270
EL LA V+KE A + V L + + K+K L+EA+ + D+ +
Sbjct: 962 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKV 1021
Query: 271 PLLD---SKQNQELQDLKNHYKKKMEV-MDLHRKVNEELEEALEACENARLKAQQIKEEI 326
L +K Q++ DL+ +++ ++ MDL R +LE L+ + + + + K+++
Sbjct: 1022 NTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLER-AKRKLEGDLKLAQESTMDTENDKQQL 1080
Query: 327 DKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEV-------TEAIRET 379
++ + + E + + +I +L + + IEE EEE+ +A ++
Sbjct: 1081 NEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1140
Query: 380 KSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDF-----------YAAKKTW 428
EL +S+ LE+ K E ++ + D A +K
Sbjct: 1141 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKH 1200
Query: 429 DIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIK----YL 484
++++ + ++ KL ++ +L+++IN + + K+ +E + L
Sbjct: 1201 ADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQL 1260
Query: 485 TIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEF------LK 538
+ +K K ++ + I + + + L + + ++++K A V + +G++ F LK
Sbjct: 1261 SEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELK 1320
Query: 539 KLTQGEVAAGMVLQKKLYSI----------YEVQALERKELIKNRAICAMSLAE----LQ 584
+ + E A L L S YE + + EL + + +A+ +
Sbjct: 1321 RQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYE 1380
Query: 585 EPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETE 644
+Q +E E + K+ + L + + + + K ++K ++ + D +I+ E
Sbjct: 1381 TDAIQRTEELEEAK---KKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVE 1437
Query: 645 -SKRSAIFKDLEATKSKTMI--FYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRF 701
S + I D + ++ + K E EL+A ++E +S L +KN +
Sbjct: 1438 RSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLD 1497
Query: 702 KREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEEN----- 756
E + + QE D E+I E + L V+ K L + + SLEE
Sbjct: 1498 HLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVK-KQLDHEKSELQTSLEEAEASLE 1556
Query: 757 ------LRLAQEYQQLQITF---LKEKD--------NYFNIYDK-QLSLDTSIRDKKQLC 798
LR+ E Q++ + EKD N+ + + Q +LD IR +
Sbjct: 1557 HEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDAL 1616
Query: 799 QLQRRMH------TLWQEHFKLVVLFSQMRLANFQ-------------TDSQESIQKILA 839
+++++M + H + L N Q Q+ +++ LA
Sbjct: 1617 RIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLA 1676
Query: 840 VQEESSNLMQ 849
+ E +NLMQ
Sbjct: 1677 MVERRANLMQ 1686
Score = 60.8 bits (146), Expect = 5e-09
Identities = 103/547 (18%), Positives = 217/547 (39%), Gaps = 62/547 (11%)
Query: 150 EKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSR-------KNMINMKI 202
E+ + C L ++ + E +A+ E + K+ RS KN +
Sbjct: 1437 ERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESL 1496
Query: 203 DSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQAD 262
D K + L Q+E + E H+ + + + +K+EL+ + + +A
Sbjct: 1497 DHLETLKRENKNL--QQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEAS 1554
Query: 263 IDYMNEHGPLL--DSKQNQELQDLKNHYKKKMEVMDL----HRKVNEELEEALEACENAR 316
+++ E G +L + NQ ++ +K E +D H +V E ++ L+A +R
Sbjct: 1555 LEH--EEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSR 1612
Query: 317 LKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAI 376
A +IK++++ D+ + E + R+ + ++ N +++ + + +AI
Sbjct: 1613 NDALRIKKKMEGDLNEMEIQLNHANRQAAEA-------LRNLRNTQGILKDTQLHLDDAI 1665
Query: 377 RETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVA 436
R K +L + + ++ ++L + E +K + EL D +
Sbjct: 1666 RGQDDLKEQLAMVERRANLMQAEVEELRASLERTER-----------GRKMAEQELLDAS 1714
Query: 437 KDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLK 496
+ + T L KKLE DI++I + + +++ E + K + LK
Sbjct: 1715 ERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELK 1774
Query: 497 NIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLY 556
KE T HL + K + ME + +++ + E+ K + ++ ++L
Sbjct: 1775 ---KEQ---DTSAHLERMKKN-MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE 1827
Query: 557 SIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKD 616
S E + E +K L R++ L + NI+ +D
Sbjct: 1828 SEVESEQKHNVEAVKG-----------------LRKHERRVKELTYQTEEDRKNILRLQD 1870
Query: 617 LIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELK 676
L+ + KVK R+ + + + +K + +LE K + I +++N+L +K
Sbjct: 1871 LVDKLQTKVKAYKRQAEEAEEQSNVNL-AKFRKLQHELEEAKERADIAESQVNKL--RVK 1927
Query: 677 AKEEEKK 683
++E K
Sbjct: 1928 SREVHTK 1934
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 90.1 bits (222), Expect = 8e-18
Identities = 153/704 (21%), Positives = 288/704 (40%), Gaps = 104/704 (14%)
Query: 160 KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQK 219
K+++E L + I LE D+ EE LK++ + + KID V LQ QK
Sbjct: 1056 KRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQ-----FQK 1110
Query: 220 EHEAYLSDVIELQWHLEDKANQLQHFEKQKTE-----------LEEANAKIQADIDYMNE 268
+ + + + EL+ +E + EKQ+++ LEEA+ A I+ MN+
Sbjct: 1111 KIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIE-MNK 1169
Query: 269 HGPLLDSKQNQELQDLK-NHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEID 327
K ++L++ H + EL E ++ + + K ++ K E+
Sbjct: 1170 KREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELK 1229
Query: 328 KDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELH 387
+I IEA + S + +V + + I+ K+E+ T+ I + K L
Sbjct: 1230 MEIDDMASNIEALSKS----KSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQ 1285
Query: 388 S----LSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAIS 443
+ LS +E+ + QLT K K Q LE + +E AK+ A +
Sbjct: 1286 TQNGELSHRVEEKESLISQLT-KSKQALTQQLEELKR--------QMEEETKAKNAMAHA 1336
Query: 444 LACTK--------LTEDNKKLEIDINKITVKTNESIRK-KSKYESEIKYLTIMKLKNDKH 494
L ++ E+ ++ + ++ + K N + + ++KYE++ T + K
Sbjct: 1337 LQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1396
Query: 495 LKNIYKEAYRIGTLFHLTKHKTDEMEDKIA---EVRRKFKGREEFLKKLTQGEVAAGMVL 551
L +EA + T+ K A + +++ +G E L + + A L
Sbjct: 1397 LAQRLQEA----------EENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATL 1446
Query: 552 QKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLN-- 609
KK + +V A +++L +++A +LE + RSL E M N
Sbjct: 1447 DKKQRNFDKVLAEWKQKLDESQA--------------ELEAAQKESRSLSTELFKMRNAY 1492
Query: 610 -NIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKI 668
++DQ + +RR+ K L+++ + + ET EA K+K ++ K
Sbjct: 1493 EEVVDQLETLRRE----NKNLQEEISDLTEQIAETGKNLQ------EAEKTKKLVEQEK- 1541
Query: 669 NELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEED 728
+L+ EE + +LE ++K + ++ + ++ D + EK + E++
Sbjct: 1542 ----SDLQVALEE---VEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNS 1594
Query: 729 QRFRVLL--------AVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNI 780
QR L R L+ +K+ D E ++L +Q+ T + +
Sbjct: 1595 QRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQL 1654
Query: 781 YDKQLSLDTSIRD----KKQLCQLQRRMHTLWQEHFKLVVLFSQ 820
D QL LD ++R K+QL ++RR L +E ++ V Q
Sbjct: 1655 KDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQ 1698
Score = 68.9 bits (167), Expect = 2e-11
Identities = 133/664 (20%), Positives = 270/664 (40%), Gaps = 111/664 (16%)
Query: 271 PLLDSKQ-NQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQ-QIKEEIDK 328
PLL S + +E+ +K +++ E + +ELEE + + + Q Q++ E +
Sbjct: 842 PLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETEN 901
Query: 329 DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHS 388
+ +E+ K +I + V + +EE+EE +E + + ++ +++ S
Sbjct: 902 LMDAEERCEGLIKSKIL--------LEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSS 953
Query: 389 LSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTK 448
L + ++DL ++ ++ + EN+ + A ++ +S + K+ ++ A +
Sbjct: 954 LKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEE----NISKLTKEKKSLQEAHQQ 1009
Query: 449 LTEDNKKLEIDIN---KITVKTNESI------------------RKKSKYESEIKYL--T 485
+D + E +N KI K + R K K E ++K +
Sbjct: 1010 TLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQES 1069
Query: 486 IMKLKNDKHL--KNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQG 543
IM L+NDK + + K+ + + L + K D+ + + ++K K + +++L +
Sbjct: 1070 IMDLENDKQQIEEKLKKKEFELSQL----QAKIDDEQVHSLQFQKKIKELQARIEELEE- 1124
Query: 544 EVAAGMVLQKKLYSIYEVQALERKELI------------------KNRAICAMSLAELQE 585
E+ A L+ K+ A E +E+ K A +L+E
Sbjct: 1125 EIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEE 1184
Query: 586 PLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKK---GKKTLDALIE 642
LQ E A +R + L ID +++K+ K K +L+ + ++AL +
Sbjct: 1185 ATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSK 1244
Query: 643 TESKRSAIFKDLE--------ATKSKTMIFY------AKINELNEELKAKEEEKKS---- 684
++S + +E + +T + + A++ N EL + EEK+S
Sbjct: 1245 SKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQ 1304
Query: 685 -------FDQTLEILKNKFITMRFKREHAQTVFDHYMQEKK-DCE--ERIFEEDQRF--- 731
Q LE LK + + A+ H +Q + DC+ +EE+Q
Sbjct: 1305 LTKSKQALTQQLEELKRQM----EEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAE 1360
Query: 732 --RVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDT 789
R L + Q K D+++ L + ++L + ++N K SL+
Sbjct: 1361 LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLE- 1419
Query: 790 SIRDKKQL-CQLQRRMHTLWQEHFKLVVLFSQMR-----LANFQTDSQESIQKILAVQEE 843
+ K++L +++ M L + H L + R LA ++ ES ++ A Q+E
Sbjct: 1420 --KTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKE 1477
Query: 844 SSNL 847
S +L
Sbjct: 1478 SRSL 1481
Score = 68.9 bits (167), Expect = 2e-11
Identities = 134/735 (18%), Positives = 292/735 (39%), Gaps = 104/735 (14%)
Query: 155 KCPELKQEMETLLSEAIRLIKSL---ETDRADAEEALKQQRSRKNMINMKIDSWS--VWK 209
K E ++EM T+ + R + L E R + EE + KN + +++ S + +
Sbjct: 845 KSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMD 904
Query: 210 LQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEH 269
+E + K + V EL LE++ +K LE+ + ++ DID +
Sbjct: 905 AEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLE-- 962
Query: 270 GPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKD 329
L +K +E +N K E M LEE + + Q+ ++ D
Sbjct: 963 --LTLTKVEKEKHATENKVKNLSEEM-------TALEENISKLTKEKKSLQEAHQQTLDD 1013
Query: 330 IYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSL 389
+ +E + + +I +N +E++ +++ ++ + K
Sbjct: 1014 LQVEEDKV------------------NGLIKINAKLEQQTDDLEGSLEQEK--------- 1046
Query: 390 SKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKL 449
K+ DL R +L K + ++ ND IE K+F L
Sbjct: 1047 -KLRADLERAKRKLEGDLKMSQESIMDLEND------KQQIEEKLKKKEFELSQLQAK-- 1097
Query: 450 TEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLF 509
+D + + K K E + + E EI+ ++ K +K ++ +E I
Sbjct: 1098 IDDEQVHSLQFQK---KIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERL 1154
Query: 510 HLTKHKTDEMEDKIAEVRRKFKGREEFLKKLT-QGEVAAGMVLQKKLYSIYEV------- 561
T + + +F+ L++ T Q E A + +K+ S+ E+
Sbjct: 1155 EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNL 1214
Query: 562 ----QALERK---------ELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVML 608
Q LE++ ++ N + S + ++ +ED+ I++ D++ + ++
Sbjct: 1215 QRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLI 1274
Query: 609 NNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDL-----EATKSKTMI 663
+++ QK ++ + G++ ++ +K + + L +++ + ++L E TK+K +
Sbjct: 1275 HDLNMQKARLQTQNGELSHRVEEK-ESLISQLTKSKQALTQQLEELKRQMEEETKAKNAM 1333
Query: 664 FYA------KINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQE- 716
+A + L E+ + ++E K + L ++ R K E ++E
Sbjct: 1334 AHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEA 1393
Query: 717 KKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDN 776
KK +R+ E ++ + + +L+ T++ + +E+ +R + T K++ N
Sbjct: 1394 KKKLAQRLQEAEENTETANS-KCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRN 1452
Query: 777 YFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQK 836
+DK L+ K++L + Q + +E L +MR A +E + +
Sbjct: 1453 ----FDKVLA-----EWKQKLDESQAELEAAQKESRSLSTELFKMRNA-----YEEVVDQ 1498
Query: 837 ILAVQEESSNLMQHI 851
+ ++ E+ NL + I
Sbjct: 1499 LETLRRENKNLQEEI 1513
Score = 50.4 bits (119), Expect = 7e-06
Identities = 88/465 (18%), Positives = 194/465 (41%), Gaps = 42/465 (9%)
Query: 98 KMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCP 157
KM + ++V ++ E L+R + +E DL E + T K ++ EK +
Sbjct: 1487 KMRNAYEEVVDQL-ETLRRENKNLQE-----EISDLTEQIAETG--KNLQEAEKTKKLVE 1538
Query: 158 ELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAV 217
+ K +++ L E ++ E+ + L Q +S + ++ D ++++L
Sbjct: 1539 QEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDE----EIEQLKRNS 1594
Query: 218 QKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQ 277
Q+ EA L V++ + + A +L+ +K + +L E ++ M E L + Q
Sbjct: 1595 QRAAEA-LQSVLDAEIRSRNDALRLK--KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQ 1651
Query: 278 NQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTI 337
Q L+D + H +D + NE+L+E L E + EE+ + Q E+T
Sbjct: 1652 GQ-LKDSQLH-------LDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTR 1703
Query: 338 EAYKREIYQLN---SLFDHYSSSVINVNTNIE--------EKEEEVTEAIRETKSSKNEL 386
++E+ + L ++S+IN +E E E + E+ + +K +
Sbjct: 1704 RLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAI 1763
Query: 387 HSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLAC 446
+ M E+L++ D ++ +N + + + + L K
Sbjct: 1764 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQ------ 1817
Query: 447 TKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIG 506
KL ++LE +++ + E+++ KYE ++K +T ++ K++ + ++
Sbjct: 1818 -KLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQ 1876
Query: 507 TLFHLTKHKTDEMEDKI-AEVRRKFKGREEFLKKLTQGEVAAGMV 550
K + +E E++ ++ R + + E + + ++A V
Sbjct: 1877 AKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQV 1921
Score = 31.6 bits (70), Expect = 3.3
Identities = 59/292 (20%), Positives = 120/292 (41%), Gaps = 68/292 (23%)
Query: 97 NKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTT--------PVKEVKP 148
N+ ++ Q +Q LK + ++ R S +DLKE ++ ++E+K
Sbjct: 1637 NRQMAETQKHLRTVQGQLKDSQLHLDDALR--SNEDLKEQLAIVERRNGLLLEELEEMKV 1694
Query: 149 GEKRDEKCPELKQEMETLLSEAIRLI-----------KSLETD----RADAEEALKQQRS 193
++ E+ L ++ S+ ++L+ K LE D +A+ E ++++ R+
Sbjct: 1695 ALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRN 1754
Query: 194 -----RKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQL--QHFE 246
+K + + + + + K Q+ +++ + V +LQ H D+A QL + +
Sbjct: 1755 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQ-HRLDEAEQLALKGGK 1813
Query: 247 KQKTELEEANAKIQADIDYMNEHGPLL--------------------DSKQNQELQDLKN 286
KQ +LE +++ ++D + G D K LQDL +
Sbjct: 1814 KQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVD 1873
Query: 287 H-------YKKKMEVMDLH--------RKVNEELEEALEACENARLKAQQIK 323
YK++ E + R+V ELEEA E + A + +++
Sbjct: 1874 KLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLR 1925
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 89.7 bits (221), Expect = 1e-17
Identities = 167/849 (19%), Positives = 341/849 (40%), Gaps = 110/849 (12%)
Query: 98 KMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPG-EKRDEKC 156
K ++ +++ KI++ L + E +E T LKE + V+ G +E+C
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTL-LKEKNDLQLQVQAEAEGLADAEERC 911
Query: 157 PEL---KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQEL 213
+L K ++E + E ++ + + +AE K+++ +K D + EL
Sbjct: 912 DQLIKTKIQLEAKIKEVTE--RAEDEEEINAELTAKKRKLEDECSELKKDIDDL----EL 965
Query: 214 PLA-VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPL 272
LA V+KE A + V L + + K+K L+EA+ + D+ +
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 273 LDS---KQNQELQDLKNHYKKKMEV-MDLHRKVNEELEEALEACENARLKAQQIKEEIDK 328
L K Q++ DL+ +++ ++ MDL R +LE L+ + + + + K+++D+
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLER-AKRKLEGDLKLAQESIMDIENEKQQLDE 1084
Query: 329 DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEV-------TEAIRETKS 381
+ + E I + +I +L + + IEE EEE+ +A ++
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1144
Query: 382 SKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAA-----------KKTWDI 430
EL +S+ LE+ K E ++ + D A +K
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Query: 431 ELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIK----YLTI 486
++++ + + KL ++ +++++I+ + + K E + L+
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSE 1264
Query: 487 MKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEF------LKKL 540
+K K ++ + I + G L + + ++++K A V + +G++ F LK+
Sbjct: 1265 LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ 1324
Query: 541 TQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDE------- 593
+ E+ A L L S L R++ + + S AELQ L + E
Sbjct: 1325 LEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE----SKAELQRALSKANTEVAQWRTK 1380
Query: 594 --------AERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETES 645
E + K+ + L + + + K ++K ++ + D +++ E
Sbjct: 1381 YETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440
Query: 646 KRSAIFKDLEATKSKTMI---FYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFK 702
+A + ++ I + K E + EL+A ++E +S L +KN + +
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500
Query: 703 REHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEEN------ 756
E + + QE D E+I E +R L ++++ Q+ ++ A +LEE
Sbjct: 1501 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQA-ALEEAEASLEH 1559
Query: 757 -----LRLAQEYQQLQITF---LKEKD--------NYFNIYDK-QLSLDTSIRDKKQLCQ 799
LR+ E Q++ + EKD N+ I + Q +LD IR + +
Sbjct: 1560 EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIR 1619
Query: 800 LQRRMH------TLWQEHFKLVVLFSQMRLANFQ-------------TDSQESIQKILAV 840
L+++M + H + + N Q SQE +++ LA+
Sbjct: 1620 LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAM 1679
Query: 841 QEESSNLMQ 849
E +NL+Q
Sbjct: 1680 VERRANLLQ 1688
Score = 62.8 bits (151), Expect = 1e-09
Identities = 128/641 (19%), Positives = 263/641 (41%), Gaps = 87/641 (13%)
Query: 83 RHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETSFEEWS--RTSSTKDLKEDWSVT 140
RH C ++ + + +Q SK + ++ T +E + RT ++ K+ +
Sbjct: 1343 RHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1402
Query: 141 TPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINM 200
E + E + KC L++ + L +E L+ +E A K+QR+ ++
Sbjct: 1403 LQAAE-EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL-- 1459
Query: 201 KIDSWSVWKLQ------ELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEE 254
+ WK + EL A QKE + +++ +++ E+ +QL+ +++ L++
Sbjct: 1460 -----AEWKQKCEETHAELE-ASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQ 1513
Query: 255 ANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACEN 314
+ + I E G K+ EL+ +K ++ E +L + EE E +LE E
Sbjct: 1514 EISDLTEQIA---EGG-----KRIHELEKIKKQVEQ--EKCELQAAL-EEAEASLEHEEG 1562
Query: 315 ARLKAQ----QIKEEIDKDIYQDEKTIEAYKRE----IYQLNSLFD---HYSSSVINVNT 363
L+ Q Q+K E+D+ I + ++ I+ KR + + S D + I +
Sbjct: 1563 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1622
Query: 364 NIEEKEEEV-----------TEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHEN 412
+E E+ EA+R ++++ L L+D R + L + E
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVER 1682
Query: 413 Q--YLEA--------VNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINK 462
+ L+A + ++K + EL D ++ + T L KKLE DI++
Sbjct: 1683 RANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ 1742
Query: 463 ITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDK 522
+ + + +++ E + K + LK KE T HL + K + ME
Sbjct: 1743 MQGEMEDILQEARNAEEKAKKAITDAAMMAEELK---KEQ---DTSAHLERMKKN-MEQT 1795
Query: 523 IAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAE 582
+ +++ + E+ K + ++ QK + E++ E +N
Sbjct: 1796 VKDLQLRLDEAEQLALKGGKKQI------QKLEARVRELEGEVESEQKRN---------- 1839
Query: 583 LQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIE 642
E + L R++ L + NI+ +DL+ + KV K +++ ++ +
Sbjct: 1840 -AEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKV-KSYKRQAEEAEEQSNT 1897
Query: 643 TESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKK 683
+K + +LE + + I +++N+L +K++E K
Sbjct: 1898 NLAKFRKLQHELEEAEERADIAESQVNKL--RVKSREVHTK 1936
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 89.7 bits (221), Expect = 1e-17
Identities = 167/849 (19%), Positives = 341/849 (40%), Gaps = 110/849 (12%)
Query: 98 KMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPG-EKRDEKC 156
K ++ +++ KI++ L + E +E T LKE + V+ G +E+C
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTL-LKEKNDLQLQVQAEAEGLADAEERC 911
Query: 157 PEL---KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQEL 213
+L K ++E + E ++ + + +AE K+++ +K D + EL
Sbjct: 912 DQLIKTKIQLEAKIKEVTE--RAEDEEEINAELTAKKRKLEDECSELKKDIDDL----EL 965
Query: 214 PLA-VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPL 272
LA V+KE A + V L + + K+K L+EA+ + D+ +
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 273 LDS---KQNQELQDLKNHYKKKMEV-MDLHRKVNEELEEALEACENARLKAQQIKEEIDK 328
L K Q++ DL+ +++ ++ MDL R +LE L+ + + + + K+++D+
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLER-AKRKLEGDLKLAQESIMDIENEKQQLDE 1084
Query: 329 DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEV-------TEAIRETKS 381
+ + E I + +I +L + + IEE EEE+ +A ++
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1144
Query: 382 SKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAA-----------KKTWDI 430
EL +S+ LE+ K E ++ + D A +K
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Query: 431 ELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIK----YLTI 486
++++ + + KL ++ +++++I+ + + K E + L+
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSE 1264
Query: 487 MKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEF------LKKL 540
+K K ++ + I + G L + + ++++K A V + +G++ F LK+
Sbjct: 1265 LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ 1324
Query: 541 TQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDE------- 593
+ E+ A L L S L R++ + + S AELQ L + E
Sbjct: 1325 LEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE----SKAELQRALSKANTEVAQWRTK 1380
Query: 594 --------AERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETES 645
E + K+ + L + + + K ++K ++ + D +++ E
Sbjct: 1381 YETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440
Query: 646 KRSAIFKDLEATKSKTMI---FYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFK 702
+A + ++ I + K E + EL+A ++E +S L +KN + +
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500
Query: 703 REHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEEN------ 756
E + + QE D E+I E +R L ++++ Q+ ++ A +LEE
Sbjct: 1501 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQA-ALEEAEASLEH 1559
Query: 757 -----LRLAQEYQQLQITF---LKEKD--------NYFNIYDK-QLSLDTSIRDKKQLCQ 799
LR+ E Q++ + EKD N+ I + Q +LD IR + +
Sbjct: 1560 EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIR 1619
Query: 800 LQRRMH------TLWQEHFKLVVLFSQMRLANFQ-------------TDSQESIQKILAV 840
L+++M + H + + N Q SQE +++ LA+
Sbjct: 1620 LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAM 1679
Query: 841 QEESSNLMQ 849
E +NL+Q
Sbjct: 1680 VERRANLLQ 1688
Score = 62.8 bits (151), Expect = 1e-09
Identities = 128/641 (19%), Positives = 263/641 (41%), Gaps = 87/641 (13%)
Query: 83 RHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETSFEEWS--RTSSTKDLKEDWSVT 140
RH C ++ + + +Q SK + ++ T +E + RT ++ K+ +
Sbjct: 1343 RHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1402
Query: 141 TPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINM 200
E + E + KC L++ + L +E L+ +E A K+QR+ ++
Sbjct: 1403 LQAAE-EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL-- 1459
Query: 201 KIDSWSVWKLQ------ELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEE 254
+ WK + EL A QKE + +++ +++ E+ +QL+ +++ L++
Sbjct: 1460 -----AEWKQKCEETHAELE-ASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQ 1513
Query: 255 ANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACEN 314
+ + I E G K+ EL+ +K ++ E +L + EE E +LE E
Sbjct: 1514 EISDLTEQIA---EGG-----KRIHELEKIKKQVEQ--EKCELQAAL-EEAEASLEHEEG 1562
Query: 315 ARLKAQ----QIKEEIDKDIYQDEKTIEAYKRE----IYQLNSLFD---HYSSSVINVNT 363
L+ Q Q+K E+D+ I + ++ I+ KR + + S D + I +
Sbjct: 1563 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKK 1622
Query: 364 NIEEKEEEV-----------TEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHEN 412
+E E+ EA+R ++++ L L+D R + L + E
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVER 1682
Query: 413 Q--YLEA--------VNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINK 462
+ L+A + ++K + EL D ++ + T L KKLE DI++
Sbjct: 1683 RANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ 1742
Query: 463 ITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDK 522
+ + + +++ E + K + LK KE T HL + K + ME
Sbjct: 1743 MQGEMEDILQEARNAEEKAKKAITDAAMMAEELK---KEQ---DTSAHLERMKKN-MEQT 1795
Query: 523 IAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAE 582
+ +++ + E+ K + ++ QK + E++ E +N
Sbjct: 1796 VKDLQLRLDEAEQLALKGGKKQI------QKLEARVRELEGEVESEQKRN---------- 1839
Query: 583 LQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIE 642
E + L R++ L + NI+ +DL+ + KV K +++ ++ +
Sbjct: 1840 -AEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKV-KSYKRQAEEAEEQSNT 1897
Query: 643 TESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKK 683
+K + +LE + + I +++N+L +K++E K
Sbjct: 1898 NLAKFRKLQHELEEAEERADIAESQVNKL--RVKSREVHTK 1936
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 88.2 bits (217), Expect = 3e-17
Identities = 157/768 (20%), Positives = 304/768 (39%), Gaps = 164/768 (21%)
Query: 102 HIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKR----DEKCP 157
H+Q + K+Q++++ E EE L++ VTT K K E++ D+ C
Sbjct: 933 HLQAEKKKMQQNIQELEEQLEEEESARQKLQLEK---VTTEAKLKKLEEEQIILEDQNCK 989
Query: 158 ELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAV 217
K++ LL + I T+ + EE K KN
Sbjct: 990 LAKEKK--LLEDRIA---EFTTNLTEEEEKSKSLAKLKN--------------------- 1023
Query: 218 QKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDS-- 275
+HEA ++D+ E +L+ EKQ+ ELE+ K++ D +++ L +
Sbjct: 1024 --KHEAMITDLEE----------RLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 276 --------KQNQELQDL----------KNHYKKKMEVMDLHRKVNEELEEALEACENARL 317
K+ +ELQ KN KK + +L +++E L+E LE+ +R
Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMALKK--IRELESQISE-LQEDLESERASRN 1128
Query: 318 KAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIR 377
KA++ K ++ +++ EA K E L D S+ + K E+ ++
Sbjct: 1129 KAEKQKRDLGEEL-------EALKTE------LEDTLDSTA--AQQELRSKREQEVNILK 1173
Query: 378 ETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAK 437
+T + + H ++++R+ + Q + Q + AK+T + E ++A
Sbjct: 1174 KTLEEEAKTHEAQ--IQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELAN 1231
Query: 438 DFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKN 497
+ + KK+E + ++ VK NE R +++ ++ L + L N
Sbjct: 1232 EVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQV-------ELDN 1284
Query: 498 IYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYS 557
+ G L ++D K+ + + + + ++L Q E + L KL
Sbjct: 1285 V------TGLL-----SQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQ 1333
Query: 558 IYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDL 617
+ + + R+ QLE+E E +L+K+ + + + D K
Sbjct: 1334 VEDEKNSFRE---------------------QLEEEEEAKHNLEKQIATLHAQVADMKKK 1372
Query: 618 IRRKVG--KVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEEL 675
+ VG + +++++K +K L+ L + ++ A + LE TK++ EL++ L
Sbjct: 1373 MEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQ------QELDDLL 1426
Query: 676 KAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLL 735
+ +++S E Q FD + E+K + EE R R
Sbjct: 1427 VDLDHQRQS---------------ACNLEKKQKKFDQLLAEEKTISAKYAEE--RDRAEA 1469
Query: 736 AVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYD-----------KQ 784
R+K + +A +LEE + E ++L F E ++ + D +
Sbjct: 1470 EAREKETKALS--LARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSK 1527
Query: 785 LSLDTSIRD-KKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQ 831
+L+ + + K QL +L+ + +L V M+ A F+ D Q
Sbjct: 1528 RALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMK-AQFERDLQ 1574
Score = 65.9 bits (159), Expect = 2e-10
Identities = 113/600 (18%), Positives = 249/600 (41%), Gaps = 75/600 (12%)
Query: 100 ISHIQDVESKIQEHLKRFETSFEEWSRTSST---------KDLKEDWSVTTPVKEVKPGE 150
+ ++D ++ +E L+ E + + +T K +++ +EVK
Sbjct: 1331 LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL 1390
Query: 151 KRDEKCPELKQEMETLLSEAIRLIKS-LETDRADAEEALKQQRSRKNMINMKIDSWSVWK 209
++D + + E + + + K+ L+ + D L QR + K +
Sbjct: 1391 QKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLL 1450
Query: 210 LQELPLAVQ--KEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADI-DYM 266
+E ++ + +E + ++ E + A L+ +QK ELE N + + ++ D M
Sbjct: 1451 AEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLM 1510
Query: 267 NEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKA----QQI 322
+ + K EL+ K ++++E M EELE+ L+A E+A+L+ Q +
Sbjct: 1511 SSKDDV--GKSVHELEKSKRALEQQVEEMKTQL---EELEDELQATEDAKLRLEVNLQAM 1565
Query: 323 KEEIDKDIY-QDEKTIEAYKREIYQLNSLFDHYSSS-----------------VINVNTN 364
K + ++D+ +DE++ E K+ + Q+ + + ++ +
Sbjct: 1566 KAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAH 1625
Query: 365 IEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHEN----------QY 414
I+ + EAI++ + + ++ + L+D R +++ + K +E Q
Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQL 1685
Query: 415 LEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKK 474
E + AK+ E ++A + + S E+ ++LE I ++ + E
Sbjct: 1686 QEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNT 1745
Query: 475 SKYESEIKY--LTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAE----VRR 528
+K L I ++ D +L+ + A + + + E++ K+ E V+
Sbjct: 1746 ELINDRLKKANLQIDQINTDLNLERSH--AQKNENARQQLERQNKELKVKLQEMEGTVKS 1803
Query: 529 KFKGREEFLK-KLTQGEVAAGMVLQKKLYSIYEVQALERK---------------ELIKN 572
K+K L+ K+ Q E +++ + +V+ E+K E K+
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD 1863
Query: 573 RAICAMS-LAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRK 631
+A A + L +L+ L + E+EA+R + ++ L + + D + R+V +K KLR+
Sbjct: 1864 QADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923
Score = 60.8 bits (146), Expect = 5e-09
Identities = 137/663 (20%), Positives = 274/663 (41%), Gaps = 98/663 (14%)
Query: 217 VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTEL---EEANAKIQADIDYMNEHGPLL 273
+Q+ AYL W L K L +Q+ E+ EE K++ L
Sbjct: 812 LQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREK--------QLA 863
Query: 274 DSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACE-NARLKAQQIKEEIDKDIYQ 332
+ E++ L++ E + L ++ E E EA E ARL A+ K+E+++ +
Sbjct: 864 AENRLTEMETLQSQLMA--EKLQLQEQLQAETELCAEAEELRARLTAK--KQELEEICHD 919
Query: 333 DEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKM 392
E +E + H + + NI+E EE+ + E +S++ +L
Sbjct: 920 LEARVEEEEERC-------QHLQAEKKKMQQNIQELEEQ----LEEEESARQKL------ 962
Query: 393 LEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTED 452
L +V + K+ E LE N A +K L D +F+ T LTE+
Sbjct: 963 --QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKL---LEDRIAEFT------TNLTEE 1011
Query: 453 NKKLEIDINKITVKTNESIRK-KSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHL 511
+K ++S+ K K+K+E+ I L + +K + + K ++
Sbjct: 1012 EEK------------SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTD 1059
Query: 512 TKHKTDEMEDKIAEVRRKFKGREEFLKKL---TQGEVAAGMVLQKKLYSIYEVQALERKE 568
+ E++ +IAE++ + +EE L+ + E A + KK+ + E Q E +E
Sbjct: 1060 LSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIREL-ESQISELQE 1118
Query: 569 LIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRK---VGKV 625
+++ + + AE Q+ D E + +L E L++ Q++L ++ V +
Sbjct: 1119 DLESER-ASRNKAEKQK-----RDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNIL 1172
Query: 626 KKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSF 685
KK L ++ K + E K S ++L +T A + + + L E E+
Sbjct: 1173 KKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTL---ENERGEL 1229
Query: 686 DQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVR----QKT 741
+++L + + EH + + +QE + F E +R R LA + Q
Sbjct: 1230 ANEVKVL----LQGKGDSEHKRKKVEAQLQEL----QVKFNEGERVRTELADKVTKLQVE 1281
Query: 742 LQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRD-------- 793
L + +++ S ++ +L +++ L+ ++ ++LSL T ++
Sbjct: 1282 LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSF 1341
Query: 794 KKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAVQEESSNLMQHILG 853
++QL + + H L ++ + L +Q +A+ + ++S+ + +E L + + G
Sbjct: 1342 REQLEEEEEAKHNLEKQ---IATLHAQ--VADMKKKMEDSVGCLETAEEVKRKLQKDLEG 1396
Query: 854 FFQ 856
Q
Sbjct: 1397 LSQ 1399
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 88.2 bits (217), Expect = 3e-17
Identities = 145/721 (20%), Positives = 298/721 (41%), Gaps = 89/721 (12%)
Query: 125 SRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCP-ELKQEMETLLSEAIRLIKSLETD--- 180
+RTSS D S+ + +++ + + E++Q+ T + +++K L+ +
Sbjct: 414 NRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQ 473
Query: 181 RADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKAN 240
R + E + Q K ++ +I+ + QE E+E + +
Sbjct: 474 RRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENE------------VSTLKD 521
Query: 241 QLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRK 300
QL+ +K + AN K+ + E LL ++ + ++ K+H + + L
Sbjct: 522 QLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLE-S 580
Query: 301 VNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKRE-------IYQLNSLFDH 353
+N EL+E EN+ K + DKD YQ + +EA +R+ I L +
Sbjct: 581 LNRELQERNRILENS-------KSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITS 633
Query: 354 YSSSVINVNTNIEEKEEEVTEA---IRETKSSKNELH-SLSKMLEDLRRVYDQLTWKQKS 409
V ++ N+E+ E E EA + ++ KN L L+ L+ L++ +Q + K
Sbjct: 634 LQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKV 693
Query: 410 HENQYLEAVNDFYAAKKTWDIELSDVAK-DFSAISLACTKLTEDNKK---LEIDINKITV 465
+ + + AK E+ K + A A ++ + K+ L++D+ +
Sbjct: 694 TKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQ 753
Query: 466 KTNESIRKKSKYESEIKYLTI-MKLKNDKHL---KNIYKEAYRIGTLFHLTKHKTDE--- 518
K K + E E+K LT+ ++ +++K L + +A+ L L K E
Sbjct: 754 KLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINT 813
Query: 519 -------MEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELI- 570
+E ++A++ ++++G E +++L Q ++ A ++ ++Y+ Q E KE I
Sbjct: 814 LLEAKRLLEFELAQLTKQYRGNEGQMREL-QDQLEA----EQYFSTLYKTQVKELKEEIE 868
Query: 571 -KNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKL 629
KNR + ELQ L + + + + + + +Q + ++ K +
Sbjct: 869 EKNRE-NLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRN 927
Query: 630 RKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEE-----KKS 684
R++ + E S + KD+E + + K+ + EE K ++EE K +
Sbjct: 928 RQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAA 987
Query: 685 FDQTL---------------EILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQ 729
F++ + EI+ K + K+ + Q + + +K + + +E +
Sbjct: 988 FEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRK-LQLELNQERE 1046
Query: 730 RFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDT 789
+F ++ QK L D Q A +EE +LQ+ ++ + + K L L
Sbjct: 1047 KFNQMVVKHQKELNDMQ---AQLVEE----CAHRNELQMQLASKESDIEQLRAKLLDLSD 1099
Query: 790 S 790
S
Sbjct: 1100 S 1100
Score = 52.0 bits (123), Expect = 2e-06
Identities = 98/546 (17%), Positives = 222/546 (40%), Gaps = 97/546 (17%)
Query: 320 QQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRET 379
+ ++E + K IY+ E+ + E+ + + +S I ++ ++E +EE + R
Sbjct: 422 KSLQESLQKTIYKLEEQLH---NEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQR-RNL 477
Query: 380 KSSKNELHSLSKMLE----DLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDV 435
+S+ +++ +L+ + +R +Q K+++ EN+ T +L D+
Sbjct: 478 ESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEV-----------STLKDQLEDL 526
Query: 436 AKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHL 495
K LA KL++ K+LE + N+ +R +S ++ K+ L
Sbjct: 527 KKVSQNSQLANEKLSQLQKQLE--------EANDLLRTESDTAVRLRKSHTEMSKSISQL 578
Query: 496 KNIYKEAYRIGTLFHLTKHKTDE---MEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQ 552
+++ +E + +K +TD+ I E R+ +G + +
Sbjct: 579 ESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEM--------------- 623
Query: 553 KKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNII 612
I ++QA + LQE + L+ E++ KE MLN+
Sbjct: 624 -----IGDLQA---------------RITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSE 663
Query: 613 DQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELN 672
+K+ + + K L+++ ++ ++ T+++ + + +E KS M E+
Sbjct: 664 KEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMC------EME 717
Query: 673 EELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERI------FE 726
++LK + E ++ + + ++ + + + +Q +H K+ E+ + E
Sbjct: 718 KKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLE 777
Query: 727 EDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLS 786
++ R+LL K TQ AD NL+ ++ + +I L E QL+
Sbjct: 778 QESNKRLLLQNELK----TQAFEAD----NLKGLEKQMKQEINTLLEAKRLLEFELAQLT 829
Query: 787 L-----DTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAVQ 841
+ +R+ + + ++ TL++ K + + ++E+++KI +Q
Sbjct: 830 KQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKEL-------KEEIEEKNRENLKKIQELQ 882
Query: 842 EESSNL 847
E L
Sbjct: 883 NEKETL 888
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 87.8 bits (216), Expect = 4e-17
Identities = 178/871 (20%), Positives = 357/871 (40%), Gaps = 154/871 (17%)
Query: 126 RTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRL---IKSLETDRA 182
R +KE++ T +KE EK + + EL+++M +LL E L +++ + + A
Sbjct: 845 REKEMASMKEEF---TRLKEAL--EKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLA 899
Query: 183 DAEEALKQQRSRKNMINMKI-------------------------DSWSVWKLQ----EL 213
DAEE Q K + K+ D S K EL
Sbjct: 900 DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLEL 959
Query: 214 PLA-VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPL 272
LA V+KE A + V L + + K+K L+EA+ + D+ +
Sbjct: 960 TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNT 1019
Query: 273 LDS---KQNQELQDLKNHYKKKMEV-MDLHRKVNEELEEALEACENARLKAQQIKEEIDK 328
L K Q++ DL+ +++ +V MDL R +LE L+ + + + + K+++D+
Sbjct: 1020 LTKAKVKLEQQVDDLEGSLEQEKKVRMDLER-AKRKLEGDLKLTQESIMDLENDKQQLDE 1078
Query: 329 DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHS 388
+ + + + A I +L + + IEE EEE+ EA R ++ +L S
Sbjct: 1079 RLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEEL-EAERTARAKVEKLRS 1137
Query: 389 -LSKMLEDLRR----------VYDQLTWKQKSH--------ENQYLEAVNDFYAAKKTWD 429
LS+ LE++ V ++ K+++ E L+ A +K
Sbjct: 1138 DLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHA 1197
Query: 430 IELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKL 489
++++ + + KL ++ + +++++ +T + I+ K+ E + T+
Sbjct: 1198 DSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCR--TLEDQ 1255
Query: 490 KNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGM 549
N+ K +E R ++ LT + +++ + E+ R+ +E + +LT+G++
Sbjct: 1256 MNEHRSK--AEETQR--SVNDLTSQRA-KLQTENGELSRQLDEKEALISQLTRGKLTYTQ 1310
Query: 550 VLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLL--QLEDEAERIRSLDKEHSVM 607
L+ + LE + KN A+ A LL Q E+E E L + S
Sbjct: 1311 QLEDL------KRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKA 1364
Query: 608 LNNIID-----QKDLIRR--KVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSK 660
+ + + D I+R ++ + KKKL ++ ++ +A+ +K S++ K +++
Sbjct: 1365 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE 1424
Query: 661 TMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKF-----------------ITMRFKR 703
+ N A ++++++FD+ L K K+ T FK
Sbjct: 1425 IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1484
Query: 704 EHA-QTVFDH---YMQEKKDCEERI-------------FEEDQRFRVLLAVRQKTLQDTQ 746
++A + +H + +E K+ +E I E ++ R L + LQ
Sbjct: 1485 KNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSAL 1544
Query: 747 KIIADSLEEN----LRLAQEYQQLQITF---LKEKD--------NYFNIYDK-QLSLDTS 790
+ SLE LR E+ Q++ L EKD N+ + D Q SLD
Sbjct: 1545 EEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAE 1604
Query: 791 IRDKKQLCQLQRRMH------TLWQEHFKLVVLFSQMRLANFQT---DSQ---------- 831
R + + +++++M + H + +Q ++ + Q+ D+Q
Sbjct: 1605 TRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAN 1664
Query: 832 ESIQKILAVQEESSNLMQHILGFFQTLTDGT 862
+ +++ +A+ E +NL+Q L + + + T
Sbjct: 1665 DDLKENIAIVERRNNLLQAELEELRAVVEQT 1695
Score = 59.7 bits (143), Expect = 1e-08
Identities = 112/631 (17%), Positives = 255/631 (40%), Gaps = 76/631 (12%)
Query: 162 EMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSV-WKLQELPLAVQKE 220
E E L+S+ R + D + L+++ KN + + S L + E
Sbjct: 1293 EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETE 1352
Query: 221 HEAYLSDVIE------LQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLD 274
+A L V+ QW + + + +Q E ELEEA K+ + E ++
Sbjct: 1353 AKAELQRVLSKANSEVAQWRTKYETDAIQRTE----ELEEAKKKLAQRLQEAEEAVEAVN 1408
Query: 275 SKQNQELQDLKNHYKKKME--VMDLHRK--VNEELEEALEACENARLKAQQIKEEIDKDI 330
+K + L+ K+ + ++E ++D+ R L++ + + +Q EE ++
Sbjct: 1409 AKCSS-LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSEL 1467
Query: 331 YQDEKTIEAYKREIYQLNSLFDH---YSSSVINVNTNIEEKEEEVTEAIRETKSSKNELH 387
+K + E+++L + ++ + + N N++E+ ++TE + + + +EL
Sbjct: 1468 ESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELE 1527
Query: 388 SLSKMLE----DLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAIS 443
+ K LE +L+ ++ + E + L A +F K + +L++ ++
Sbjct: 1528 KVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAK 1587
Query: 444 LACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAY 503
++ + L+ ++ T NE++R K K E ++ + I ++ K+
Sbjct: 1588 RNHLRVVDS---LQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVK 1644
Query: 504 RIGTLFHLTK-------HKTDEMEDKIAEVRRKFKGREEFLKKLT----QGEVAAGMVLQ 552
+ +L T+ D++++ IA V R+ + L++L Q E + + Q
Sbjct: 1645 SLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQ 1704
Query: 553 KKLYSIYEVQAL--ERKELIKNRAICAMSLAELQ----EPLLQLEDEAERIRSLDKEHSV 606
+ + + VQ L + LI + L++LQ E + + + E+ + + ++
Sbjct: 1705 ELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAM 1764
Query: 607 MLNNIIDQKDL-----------------IRRKVGKVKKKLRKKGKKTLDAL--------- 640
M + ++D ++ ++ + ++ K GKK L L
Sbjct: 1765 MAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEN 1824
Query: 641 -IETESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITM 699
+E E KR+A E+ K +I EL + + + ++ L+ K
Sbjct: 1825 ELEAEQKRNA-----ESVKGMRK-SERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAY 1878
Query: 700 RFKREHAQTVFDHYMQEKKDCEERIFEEDQR 730
+ + E A+ + + + + + + E ++R
Sbjct: 1879 KRQAEEAEEQANTNLSKFRKVQHELDEAEER 1909
Score = 52.0 bits (123), Expect = 2e-06
Identities = 87/461 (18%), Positives = 182/461 (39%), Gaps = 71/461 (15%)
Query: 380 KSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDF 439
KS++ E ++ M E+ R+ + L K ++ + E + K +++ +
Sbjct: 841 KSAERE-KEMASMKEEFTRLKEALE-KSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNL 898
Query: 440 SAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIY 499
+ C +L ++ +LE + ++ NE + + + +E LT K K + +
Sbjct: 899 ADAEERCDQLIKNKIQLEAKVKEM----NERLEDEEEMNAE---LTAKKRKLEDECSEL- 950
Query: 500 KEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQ-----GEVAAGMVLQKK 554
K D++E +A+V ++ E +K LT+ E+ A + +KK
Sbjct: 951 -------------KRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 997
Query: 555 LYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQ 614
QAL+ + +++ + L + ++LE + + L ++Q
Sbjct: 998 ALQEAHQQALDDLQAEEDK------VNTLTKAKVKLEQQVDD-----------LEGSLEQ 1040
Query: 615 KDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAI-----FKDLEAT------------ 657
+ +R + + K+KL K T +++++ E+ + + KD E
Sbjct: 1041 EKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQAL 1100
Query: 658 ----KSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKF--ITMRFKREHAQTVFD 711
+ K A+I EL EEL+A+ + ++ L + I+ R + T
Sbjct: 1101 GSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQ 1160
Query: 712 HYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFL 771
M +K++ E + D L + T +K ADS+ E Q+++
Sbjct: 1161 IEMNKKREAEFQKMRRDLEEATL--QHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE 1218
Query: 772 KEKDNY-FNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEH 811
KEK + + D +++ I+ K L ++ R + EH
Sbjct: 1219 KEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEH 1259
Score = 41.2 bits (95), Expect = 0.004
Identities = 55/298 (18%), Positives = 122/298 (40%), Gaps = 35/298 (11%)
Query: 97 NKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVT--------TPVKEVKP 148
N+M + Q +Q LK + ++ R + DLKE+ ++ ++E++
Sbjct: 1633 NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND--DLKENIAIVERRNNLLQAELEELRA 1690
Query: 149 GEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVW 208
++ E+ +L ++ SE ++L+ S T + ++ + S+ + +++
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQ---LQTEVEE---- 1743
Query: 209 KLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNE 268
+QE A +K +A ++D + L+ + + H E+ K +E+ +Q +D +
Sbjct: 1744 AVQECRNAEEKAKKA-ITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQ 1802
Query: 269 HGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDK 328
KQ Q+L+ ELE LEA + ++ + + ++
Sbjct: 1803 IALKGGKKQLQKLEARVR-----------------ELENELEAEQKRNAESVKGMRKSER 1845
Query: 329 DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNEL 386
I + E ++ + +L L D V EE EE+ + + + ++EL
Sbjct: 1846 RIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 1903
Score = 32.7 bits (73), Expect = 1.5
Identities = 53/251 (21%), Positives = 104/251 (41%), Gaps = 32/251 (12%)
Query: 97 NKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKC 156
N + + ++++ + +++ + + + +E TS L + + + +K D
Sbjct: 1679 NLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL----INQKKKMDADL 1734
Query: 157 PELKQEMETLLSE---AIRLIKSLETDRAD-AEEALKQQRSRKNMINMKIDSWSVWK--L 210
+L+ E+E + E A K TD A AEE K+Q + ++ MK + K
Sbjct: 1735 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1794
Query: 211 QELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQA---DIDYMN 267
L A Q + + +L+ + + N+L+ +K+ E + K + ++ Y
Sbjct: 1795 HRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQT 1854
Query: 268 EHGPLLDSKQNQELQDLKNH-------YKKKMEV--------MDLHRKVNEELEEALEAC 312
E D K LQDL + YK++ E + RKV EL+EA E
Sbjct: 1855 EE----DRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1910
Query: 313 ENARLKAQQIK 323
+ A + +++
Sbjct: 1911 DIAESQVNKLR 1921
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 87.8 bits (216), Expect = 4e-17
Identities = 162/845 (19%), Positives = 342/845 (40%), Gaps = 145/845 (17%)
Query: 150 EKRDEKCPELKQEMETLLSEAIRL---IKSLETDRADAEEALKQQRSRKNMINMKIDSWS 206
EK + + EL+++M +LL E L +++ + + DAEE Q K + K+ +
Sbjct: 866 EKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMN 925
Query: 207 --VWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQK-------TELEEANA 257
+ +E+ + + + EL+ ++D L EK+K L E A
Sbjct: 926 ERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 985
Query: 258 KIQADIDYMNEHGPLLDSKQNQELQDL-----------KNHYKKKMEVMDLH------RK 300
+ I + + L Q L DL K+ K + +V DL +K
Sbjct: 986 GLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKK 1045
Query: 301 VNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVIN 360
V +LE A E Q+ +++ D Q E+ ++ + +I Q NS + +
Sbjct: 1046 VRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQ 1105
Query: 361 VNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWK-------------- 406
+ ++E + + E E ++ + + K+ DL R ++++ +
Sbjct: 1106 LQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEM 1165
Query: 407 QKSHENQYLEAVNDF-----------YAAKKTWDIELSDVAKDFSAISLACTKLTEDNKK 455
K E ++ + D A +K ++++ + + KL ++ +
Sbjct: 1166 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1225
Query: 456 LEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHK 515
+++++ +T + I+ K+ E + T+ N+ +K +EA R +L T +
Sbjct: 1226 FKLELDDVTSNMEQIIKAKANLEKVSR--TLEDQANEYRVK--LEEAQR--SLNDFTTQR 1279
Query: 516 TDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAI 575
+++ + E+ R+ + +E + +LT+G+++ ++ + LE + KN
Sbjct: 1280 A-KLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDL------KRQLEEEGKAKNALA 1332
Query: 576 CAMSLAELQEPLL--QLEDEAERIRSLDKEHSVMLNNIID-----QKDLIRR--KVGKVK 626
A+ A LL Q E+E E L + S + + + D I+R ++ + K
Sbjct: 1333 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 1392
Query: 627 KKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFD 686
KKL ++ + +A+ +K S++ K +++ + N A ++++++FD
Sbjct: 1393 KKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFD 1452
Query: 687 QTLEILKNKF-----------------ITMRFKREHA-QTVFDH---YMQEKKDCEERIF 725
+ L K K+ T FK ++A + +H + +E K+ +E I
Sbjct: 1453 KILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS 1512
Query: 726 E-------------EDQRFRVLLAVRQKTLQDTQKIIADSLEEN----LRLAQEYQQLQI 768
+ E ++ R L V + LQ + SLE LR E+ Q++
Sbjct: 1513 DLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1572
Query: 769 TF---LKEKD--------NYFNIYDK-QLSLDTSIRDKKQLCQLQRRMH------TLWQE 810
L EKD N+ + D Q SLD R + ++ +++++M +
Sbjct: 1573 EIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLS 1632
Query: 811 HFKLVVLFSQMRLANFQT---DSQ----------ESIQKILAVQEESSNLMQHILGFFQT 857
H + +Q ++ + Q+ D+Q + +++ +A+ E +NL+Q L +
Sbjct: 1633 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1692
Query: 858 LTDGT 862
+ + T
Sbjct: 1693 VVEQT 1697
Score = 80.1 bits (196), Expect = 8e-15
Identities = 151/793 (19%), Positives = 321/793 (40%), Gaps = 138/793 (17%)
Query: 96 VNKMISHIQD-------VESKIQEHLKRFETSFEEWS--RTSSTK--DLKEDWS-----V 139
+N+ S I+D ++ K++E+ R E EE RT+ K L+ D S +
Sbjct: 1089 INQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEI 1148
Query: 140 TTPVKE--------VKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQ 191
+ ++E ++ +KR+ + ++++++E + +L AD+ L +Q
Sbjct: 1149 SERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQ 1208
Query: 192 RSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTE 251
ID+ LQ + ++KE E + L+D + ++ K K
Sbjct: 1209 ----------IDN-----LQRVKQKLEKEKS-------EFKLELDDVTSNMEQIIKAKAN 1246
Query: 252 LEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEA 311
LE+ + ++ D NE+ L+ Q K + E +L R++ EE E +
Sbjct: 1247 LEKVSRTLE---DQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQL-EEKEALISQ 1302
Query: 312 CENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEE 371
+L Q E++ + + ++ K A H S + + E+ EE
Sbjct: 1303 LTRGKLSYTQQMEDLKRQLEEEGKAKNA-----------LAHALQSARHDCDLLREQYEE 1351
Query: 372 VTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIE 431
TEA E + ++ +S + W+ K +E ++ + AKK
Sbjct: 1352 ETEAKAELQRVLSKANS------------EVAQWRTK-YETDAIQRTEELEEAKKKLAQR 1398
Query: 432 LSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNES----IRKKSKYESEIKYLTIM 487
L D + A++ C+ L + +L+ +I + V S K + K L
Sbjct: 1399 LQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEW 1458
Query: 488 KLK---NDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQ-- 542
K K + L++ KEA + T K+ +E + + +R+ K +E + LT+
Sbjct: 1459 KQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL 1518
Query: 543 GEVAAGMVLQKKLYSIYEVQALERK---------------ELIKNRAICAMSLAELQEPL 587
GE + +K+ EV+ LE + ++++ + AE++ L
Sbjct: 1519 GEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKL 1578
Query: 588 LQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKR 647
+ ++E E+ + + L +D + R +V +VKKK+ +G + + + R
Sbjct: 1579 AEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKM--EGDLNEMEIQLSHANR 1636
Query: 648 SAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQ 707
A + ++++ +I +L++ ++A ++ K + + I++ + ++ + E +
Sbjct: 1637 MAAEAQKQVKSLQSLLKDTQI-QLDDAVRANDDLK----ENIAIVERRNNLLQAELEELR 1691
Query: 708 TVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLE---------ENLR 758
V + + +K E+ + E +R ++L + + +K+ +D + + R
Sbjct: 1692 AVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECR 1751
Query: 759 LAQEYQQLQIT--------FLKEKDNYFNIYDKQLSLDTSIRD----------------K 794
A+E + IT KE+D ++ + +++ +I+D K
Sbjct: 1752 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGK 1811
Query: 795 KQLCQLQRRMHTL 807
KQL +L+ R+ L
Sbjct: 1812 KQLQKLEARVREL 1824
Score = 64.3 bits (155), Expect = 5e-10
Identities = 124/695 (17%), Positives = 274/695 (39%), Gaps = 87/695 (12%)
Query: 98 KMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCP 157
K ++++ V +++ + EE R+ + D++ + + GE +
Sbjct: 1242 KAKANLEKVSRTLEDQANEYRVKLEEAQRSLN------DFTTQRAKLQTENGELARQL-- 1293
Query: 158 ELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSV-WKLQELPLA 216
+E E L+S+ R S D + L+++ KN + + S L
Sbjct: 1294 ---EEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYE 1350
Query: 217 VQKEHEAYLSDVIE------LQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHG 270
+ E +A L V+ QW + + + +Q E ELEEA K+ + E
Sbjct: 1351 EETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTE----ELEEAKKKLAQRLQDAEEAV 1406
Query: 271 PLLDSKQNQELQDLKNHYKKKME--VMDLHRK--VNEELEEALEACENARLKAQQIKEEI 326
+++K + L+ K+ + ++E ++D+ R L++ + + +Q EE
Sbjct: 1407 EAVNAKCSS-LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1465
Query: 327 DKDIYQDEKTIEAYKREIYQLNSLFDH---YSSSVINVNTNIEEKEEEVTEAIRETKSSK 383
++ +K + E+++L + ++ + + N N++E+ ++TE + E +
Sbjct: 1466 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNV 1525
Query: 384 NELHSLSKMLE----DLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDF 439
+EL + K LE +L+ ++ + E + L A +F K + +L++ ++
Sbjct: 1526 HELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEM 1585
Query: 440 SAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIY 499
++ + L+ ++ T NE +R K K E ++ + I ++
Sbjct: 1586 EQAKRNHQRVVDS---LQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQ 1642
Query: 500 KEAYRIGTLFHLTK-------HKTDEMEDKIAEVRRKFKGREEFLKKLT----QGEVAAG 548
K+ + +L T+ D++++ IA V R+ + L++L Q E +
Sbjct: 1643 KQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRK 1702
Query: 549 MVLQKKLYSIYEVQAL--ERKELIKNRAICAMSLAELQEPLLQ---------------LE 591
+ Q+ + + VQ L + LI + L +LQ + + +
Sbjct: 1703 LAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAIT 1762
Query: 592 DEAERIRSLDKEHSVM----------------LNNIIDQKDLIRRKVGKVKKKLRKKGKK 635
D A L KE L + +D+ + I K GK + + + +
Sbjct: 1763 DAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVR 1822
Query: 636 TLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNK 695
L+ +E E KR+A E+ K +I EL + + ++ ++ L+ K
Sbjct: 1823 ELEGELEAEQKRNA-----ESVKGMRK-SERRIKELTYQTEEDKKNLLRLQDLVDKLQLK 1876
Query: 696 FITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQR 730
+ + E A+ + + + + + + E ++R
Sbjct: 1877 VKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEER 1911
Score = 45.1 bits (105), Expect = 3e-04
Identities = 63/332 (18%), Positives = 132/332 (39%), Gaps = 42/332 (12%)
Query: 97 NKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVT--------TPVKEVKP 148
N+M + Q +Q LK + ++ R + DLKE+ ++ ++E++
Sbjct: 1635 NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND--DLKENIAIVERRNNLLQAELEELRA 1692
Query: 149 GEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVW 208
++ E+ +L ++ SE ++L+ S T + + K+ S + +++
Sbjct: 1693 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK---KKMESDLTQLQSEVEE---- 1745
Query: 209 KLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNE 268
+QE A +K +A ++D + L+ + + H E+ K +E+ +Q +D +
Sbjct: 1746 AVQECRNAEEKAKKA-ITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQ 1804
Query: 269 HGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDK 328
KQ Q+L+ ELE LEA + ++ + + ++
Sbjct: 1805 IALKGGKKQLQKLEARVR-----------------ELEGELEAEQKRNAESVKGMRKSER 1847
Query: 329 DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHS 388
I + E K+ + +L L D V EE EE+ + + + ++EL
Sbjct: 1848 RIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDE 1907
Query: 389 LSK-------MLEDLRRVYDQLTWKQKSHENQ 413
+ + LR + KQK H+ +
Sbjct: 1908 AEERADIAESQVNKLRAKSRDIGAKQKMHDEE 1939
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 86.7 bits (213), Expect = 9e-17
Identities = 153/777 (19%), Positives = 317/777 (40%), Gaps = 99/777 (12%)
Query: 153 DEKCPEL---KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWK 209
+E+C +L K ++E + E ++ + + +AE K+++ +K D +
Sbjct: 903 EERCDQLIKAKFQLEAKIKEVTE--RAEDEEEINAELTAKKRKLEDECSELKKDIDDL-- 958
Query: 210 LQELPLA-VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAK----IQADID 264
EL LA V+KE A + V L L + ++K L+EA+ + +QA+ D
Sbjct: 959 --ELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEED 1016
Query: 265 YMNEHGPLLDSKQNQELQDLKNHYKKKMEV-MDLHRKVNEELEEALEACENARLKAQQIK 323
+N SK Q+++DL++ +++ ++ +DL R +LE L+ + + L + K
Sbjct: 1017 KVNSLNKT-KSKLEQQVEDLESSLEQEKKLRVDLERN-KRKLEGDLKLAQESILDLENDK 1074
Query: 324 EEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSS- 382
+++D+ + + + + ++ +L + + + IEE EEE+ EA R T++
Sbjct: 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEI-EAERATRAKT 1133
Query: 383 -------KNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDF-----------YAA 424
EL LS+ LE+ V K E ++L+ D A
Sbjct: 1134 EKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAAL 1193
Query: 425 KKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIK-- 482
+K ++++ + + KL ++ + +++I+ ++ + K+ E +
Sbjct: 1194 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTL 1253
Query: 483 --YLTIMKLKND---KHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRK---FKGRE 534
L+ + KN+ + L + + R+ T + +E E ++++ R F +
Sbjct: 1254 EDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQT 1313
Query: 535 EFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDE- 593
E LK+ + E A L L S L R++ + + AELQ L + E
Sbjct: 1314 EELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQE----GKAELQRALSKANSEV 1369
Query: 594 --------------AERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDA 639
E + K+ + L + +Q + + K ++K ++ + D
Sbjct: 1370 AQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDL 1429
Query: 640 LIETE---SKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKF 696
+++ E S +A+ K + K E EL+A +E +S L LKN +
Sbjct: 1430 MVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAY 1489
Query: 697 ITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVR----------QKTLQDTQ 746
+ E + + QE D E+I E + L R Q L++ +
Sbjct: 1490 EEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAE 1549
Query: 747 KIIADSLEENLRLAQEYQQLQITF---LKEKD--------NY-FNIYDKQLSLDTSIRDK 794
+ + LR+ E Q++ + EKD NY + Q +LD +R +
Sbjct: 1550 AALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSR 1609
Query: 795 KQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAVQEESSNLMQHI 851
+ +L+++M E +++L++ + E+++ + +VQ + + H+
Sbjct: 1610 NEAIRLKKKMEGDLNE--------IEIQLSHANRQAAETLKHLRSVQGQLKDTQLHL 1658
Score = 70.5 bits (171), Expect = 6e-12
Identities = 130/773 (16%), Positives = 313/773 (40%), Gaps = 119/773 (15%)
Query: 96 VNKMISHIQDVESKIQ-EHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVK--EVKPGEKR 152
+ ++ + I+++E +I+ E R +T + ++L E V +++ +KR
Sbjct: 1109 IKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKR 1168
Query: 153 DEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQE 212
+ + +L++++E + ++ +L AD+ L +Q ID+ LQ
Sbjct: 1169 EAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQ----------IDN-----LQR 1213
Query: 213 LPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPL 272
+ ++KE E + ++D ++ ++ K K LE+ ++ D ++E
Sbjct: 1214 VKQKLEKEKS-------EFKLEIDDLSSSMESVSKSKANLEKICRTLE---DQLSEARGK 1263
Query: 273 LDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQ 332
+ Q + + + E +L R++ EE E + ++ Q EE+ + + +
Sbjct: 1264 NEEIQRSLSELTTQKSRLQTEAGELSRQL-EEKESIVSQLSRSKQAFTQQTEELKRQLEE 1322
Query: 333 DEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNEL-HSLSK 391
+ K N+L SS + + E+ EEE + K EL +LSK
Sbjct: 1323 ENKA----------KNALAHALQSSRHDCDLLREQYEEE--------QEGKAELQRALSK 1364
Query: 392 MLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTE 451
++ + W+ K +E ++ + AKK L D + A++ C L +
Sbjct: 1365 ANSEVAQ------WRTK-YETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEK 1417
Query: 452 DNKKLEIDINKITVKTNES-------IRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYR 504
++L+ ++ + V + +K+ ++ + ++ L+ KE+
Sbjct: 1418 TKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRS 1477
Query: 505 IGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQ-- 562
+ T K+ +E D++ V+R+ K E+ + LT+ G + + S +++
Sbjct: 1478 LSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELE 1537
Query: 563 -------------ALERKE--LIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVM 607
ALE +E +++ + +E+ + + ++E E+++ +
Sbjct: 1538 KADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVET 1597
Query: 608 LNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAK 667
+ + +D + R + ++KKK+ + L + + K L + + +
Sbjct: 1598 MQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQL- 1656
Query: 668 INELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEE 727
L++ L+ +E+ K + L I++ + ++ + E + + + +K E+ + +
Sbjct: 1657 --HLDDALRGQEDLK----EQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDS 1710
Query: 728 DQRFRVLLAVRQKTLQDTQKIIADSLE---------ENLRLAQEYQQLQIT--------F 770
++R ++L + +K+ D ++ + R A+E + IT
Sbjct: 1711 NERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEEL 1770
Query: 771 LKEKDNYFNIYDKQLSLDTSIRD----------------KKQLCQLQRRMHTL 807
KE+D ++ + +L+ +++D KKQ+ +L+ R+ L
Sbjct: 1771 KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIREL 1823
Score = 66.2 bits (160), Expect = 1e-10
Identities = 115/602 (19%), Positives = 257/602 (42%), Gaps = 63/602 (10%)
Query: 271 PLLDSKQNQ-ELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQ-QIKEEIDK 328
PLL S + + E+ +K ++K + + +ELEE L + Q Q++ E +
Sbjct: 839 PLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESEN 898
Query: 329 DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHS 388
+ +E+ + K + +QL + + V E++EE E + + ++E
Sbjct: 899 LLDAEERCDQLIKAK-FQLEA-------KIKEVTERAEDEEEINAELTAKKRKLEDECSE 950
Query: 389 LSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTK 448
L K ++DL ++ ++ + EN+ K ELS + + + ++
Sbjct: 951 LKKDIDDLELTLAKVEKEKHATENKV-----------KNLTEELSGLDETIAKLTREKKA 999
Query: 449 LTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLK-NIYKEAYRIGT 507
L E +++ D+ K N + KSK E +++ L L+ +K L+ ++ + ++
Sbjct: 1000 LQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLE-SSLEQEKKLRVDLERNKRKLEG 1058
Query: 508 LFHLTKHKTDEMEDKIAEVRRKFKGRE-EF--LKKLTQGEVAAGMVLQKKLYSIY-EVQA 563
L + ++E+ ++ + K ++ E+ L+ + E G+ QKK+ + ++
Sbjct: 1059 DLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEE 1118
Query: 564 LERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHS--VMLNNIIDQKDL-IRR 620
LE +E+ RA A + + + +LE+ +ER+ S + LN + + L +RR
Sbjct: 1119 LE-EEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRR 1177
Query: 621 KVGKVKKK-------LRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNE 673
+ + + LRKK ++ L E + + LE KS+ F +I++L+
Sbjct: 1178 DLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE---FKLEIDDLSS 1234
Query: 674 ELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRV 733
+++ + K + ++ L+++ R K E Q +K R +
Sbjct: 1235 SMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQK-----------SRLQT 1283
Query: 734 LLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRD 793
+ L++ + I++ Q+ ++L+ L+E++ N +L +++
Sbjct: 1284 EAGELSRQLEEKESIVSQLSRSKQAFTQQTEELK-RQLEEENKAKN------ALAHALQS 1336
Query: 794 KKQLCQLQRRMHTLWQE---HFKLVVLFSQMRLANFQTDSQ-ESIQKILAVQEESSNLMQ 849
+ C L R + QE + + + +A ++T + ++IQ+ ++E L Q
Sbjct: 1337 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1396
Query: 850 HI 851
+
Sbjct: 1397 RL 1398
Score = 57.0 bits (136), Expect = 7e-08
Identities = 110/582 (18%), Positives = 234/582 (40%), Gaps = 70/582 (12%)
Query: 24 QEVKALREKAWSRTN----------EGNAMSQSLVLYGASKENSEGFHESKMTNTEGVNK 73
QE KA ++A S+ N E +A+ ++ L A K+ ++ +S+ E VN
Sbjct: 1352 QEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSE-EQVEAVNA 1410
Query: 74 GIYFSYPCRRHSCAVVN---IPAPCVNKMISHIQDVESKIQEHLKRFETSFEEWSRTSST 130
++ V + N + + + + + L ++T EE S+
Sbjct: 1411 KCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEE-SQAELE 1469
Query: 131 KDLKEDWSVTTPVKEVKPGE----------KRDEKCPELKQEMETL----------LSEA 170
LKE S++T + ++K KR+ K L+QE+ L + E
Sbjct: 1470 ASLKESRSLSTELFKLKNAYEEALDQLETVKRENK--NLEQEIADLTEQIAENGKTIHEL 1527
Query: 171 IRLIKSLETDRAD-------AEEALKQQRSRKNMINMK---IDSWSVWKLQELPLAVQKE 220
+ K +E ++AD AE AL+ + ++ I ++ + S K+ E +++
Sbjct: 1528 EKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQL 1587
Query: 221 HEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQE 280
Y V +Q L+ + + K ++E +I+ + + N ++ +
Sbjct: 1588 KRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQA----AETLKH 1643
Query: 281 LQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAY 340
L+ ++ K +D + E+L+E L E Q EE+ + Q E+ +
Sbjct: 1644 LRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLA 1703
Query: 341 KREIYQLNS---LFDHYSSSVIN----VNTNIEEKEEEVTEAIRETKSS----KNELHSL 389
++E+ N L ++S+I+ + T++ + + EV +A R+ +++ K +
Sbjct: 1704 EQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDA 1763
Query: 390 SKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKL 449
+ M E+L++ D ++ +N + + + + L K KL
Sbjct: 1764 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQ-------KL 1816
Query: 450 TEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLF 509
++LE ++ K ES++ KYE +K LT ++ K++ + ++
Sbjct: 1817 ETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKV 1876
Query: 510 HLTKHKTDEMEDKIAEVRRKF-KGREEFLKKLTQGEVAAGMV 550
K + +E +++ KF K + E + + ++A V
Sbjct: 1877 KSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQV 1918
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 86.3 bits (212), Expect = 1e-16
Identities = 143/779 (18%), Positives = 322/779 (41%), Gaps = 71/779 (9%)
Query: 104 QDVESKIQEHLKRFETSFEEWSRTSSTKD---LKEDWSVTTPVKEVKPGEKRDEKCPELK 160
Q+V +QE L++ ++S E ++ + T LK++ T K EK +E+ K
Sbjct: 281 QEVAVYVQE-LQKLKSSVNELTQKNQTLTENLLKKEQDYT------KLEEKHNEESVSKK 333
Query: 161 QEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKE 220
TL K L+ + + + + + + + + KL+E V+ +
Sbjct: 334 NIQATLHQ------KDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETK 387
Query: 221 HEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNE-HGPLLDSKQ-- 277
++ ++ +LQ E+K QH + ++E+ + ++K+ + E HG L + +Q
Sbjct: 388 YQHLKAEFKQLQQQREEKE---QHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLS 444
Query: 278 -------NQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDI 330
Q++ DL+ + E + + EL+ L+ + + Q +++ +
Sbjct: 445 SEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKL 504
Query: 331 YQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNI---EEKEEEVTEAIRETKSSKNELH 387
+ + +E R+I + + + + NI E++ E++ I+ + L+
Sbjct: 505 REAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLN 564
Query: 388 SLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACT 447
L + L+ QLT K K+ + +A + + V + + + A
Sbjct: 565 QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLH----------DQVQEQKAHLRAAQD 614
Query: 448 KLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGT 507
++ LE +N++ + NES K S+ + +IK T + L + K A R
Sbjct: 615 RVL----SLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAE-----AAKTAQRADL 665
Query: 508 LFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQ-----GEVAAGMVLQKKLYSIYEVQ 562
HL + + ++DK E+ + ++ KL ++ + + K+ Y E +
Sbjct: 666 QNHLDTAQ-NALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724
Query: 563 ALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKV 622
E + IK ++ + +E LQ + ++ R L+ + + + Q ++ + V
Sbjct: 725 TEELEGQIKKLEADSLEVKASKEQALQ---DLQQQRQLNTDLELRATELSKQLEMEKEIV 781
Query: 623 GKVKKKLRKKG---KKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNE----EL 675
+ L+KK + L + E ++ + +D E +T I + ++N + EL
Sbjct: 782 SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTEL 841
Query: 676 KAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKK----DCEERIFEEDQRF 731
+ + EK++ L +K+K + +++++ F+ Q+ K D E+ E +
Sbjct: 842 QKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL 901
Query: 732 RVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSI 791
+V + K ++ +K + E + +L E +Q ++ ++ ++ L +I
Sbjct: 902 QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNI 961
Query: 792 RDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAVQEESSNLMQH 850
+ KQ + +++ Q K+ VL Q ++ Q++ A +E+ S L +
Sbjct: 962 NELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
Score = 84.3 bits (207), Expect = 4e-16
Identities = 141/752 (18%), Positives = 324/752 (43%), Gaps = 101/752 (13%)
Query: 150 EKRDEKCPELKQEMETLLS-EAIRLIK--SLETDRADAEEALKQQRSRKNMINMKIDSWS 206
EK + ++K + E LLS EA + + L+ A+ AL+ ++ N I ++D +
Sbjct: 635 EKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVT 694
Query: 207 VWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYM 266
KLQ+ ++EH + +L+ HL++ + E++ ELE K++AD
Sbjct: 695 A-KLQD-----KQEHCS------QLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD---- 738
Query: 267 NEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARL---KAQQIK 323
+ + + Q LQDL+ + ++ +++++LE E + RL K +
Sbjct: 739 ---SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEAL 795
Query: 324 EEIDKDIYQDEKTIEAYKREIYQLNS----LFDHYSSSVINVNTNIEEKEEEVTEAIRET 379
E I + + + E+ + K++ L+ + ++ + T +++ + E + E
Sbjct: 796 ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTEL 855
Query: 380 KSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDF 439
+ K++L +S L++ + +++ K K+ L+ K +++ + K+
Sbjct: 856 STVKDKLSKVSDSLKNSKSEFEKENQKGKA---AILDLEKTCKELKHQLQVQMENTLKEQ 912
Query: 440 SAISLACTKLTEDNKKLEIDINKI---TVKTNESIRKKSKYESEIKYLTIMKLKNDKHLK 496
+ + K E + +L++++N + ++ ++++ K E +++ I +LK K
Sbjct: 913 KELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQG-NINELKQSSEQK 971
Query: 497 NIYKEAYRIGTLFHLTKHKTD-----------------EMEDKIAEVRRKFKGREEFLKK 539
EA + G L KT+ ++KI+ ++ ++ +E K+
Sbjct: 972 KKQIEALQ-GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQ 1030
Query: 540 LTQ---GEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMS---LAELQEPLLQLEDE 593
L G + + ++ L S+ E +L +++LI NR + EL+ LE +
Sbjct: 1031 LQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQD 1090
Query: 594 AERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKD 653
+ + +E L +I +K L +++ K KL A ++
Sbjct: 1091 SAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKL-------------------AEIEE 1131
Query: 654 LEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHY 713
++ + K +I +LNEELK+ + E L+ K I + +
Sbjct: 1132 IKCRQEK------EITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE----------- 1174
Query: 714 MQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKE 773
+Q K D + E+++R + +L + + ++ +++ + +E+ +L E ++ ++ K
Sbjct: 1175 LQGKADSLKAAVEQEKRNQQIL--KDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKH 1232
Query: 774 KDNYFNIYDKQLSLDTSIRD-KKQLCQLQRRMHTLWQEHFKL--VVLFSQMRLANFQTDS 830
++N + + +L+ ++ KK+ QRR+ L ++ L + + + N Q +
Sbjct: 1233 EENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDER 1292
Query: 831 QESIQKILAVQEESSNLMQHILGFFQTLTDGT 862
+ +++ L + E L +L + L + T
Sbjct: 1293 RALLERCLKGEGEIEKLQTKVLELQRKLDNTT 1324
Score = 63.5 bits (153), Expect = 8e-10
Identities = 104/536 (19%), Positives = 229/536 (42%), Gaps = 70/536 (13%)
Query: 100 ISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPEL 159
+S ++D SK+ + LK ++ FE+ ++ L + KE+K +L
Sbjct: 855 LSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAIL----DLEKTCKELK---------HQL 901
Query: 160 KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQK 219
+ +ME L E L KSLE ++ +A LK + + +M I + + K E K
Sbjct: 902 QVQMENTLKEQKELKKSLEKEK-EASHQLKLELN--SMQEQLIQAQNTLKQNE------K 952
Query: 220 EHEAYLSDVIELQWHLEDKANQLQHFE-------KQKTELEEANAKIQADIDYMNEHGPL 272
E + ++ EL+ E K Q++ + QKTELE K+Q + +
Sbjct: 953 EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN---KLQQQLTQAAQE--- 1006
Query: 273 LDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQ 332
+ + +++ L+N+Y+K E ++L+ E+ L +Q + +++ +
Sbjct: 1007 -LAAEKEKISVLQNNYEKSQETF-------KQLQSDFYGRESELLATRQDLKSVEEKLSL 1058
Query: 333 DEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEA------IRETKSSK--- 383
++ + + + +I N L ++ + + +KE+++ E I++ KS K
Sbjct: 1059 AQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKE 1118
Query: 384 --NELHSLSKMLEDLRRVYDQLT---WKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKD 438
NE L+++ E R ++T + KSH+ + ++ + + AK+ + ++
Sbjct: 1119 LVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGK 1178
Query: 439 FSAISLACTKLTEDNKKLEIDINKITVK-TNESIRKKSKYESEIKYLTIMKLKNDKHLKN 497
++ A + + + L+ + K + E I K++K SEIK + K++++
Sbjct: 1179 ADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAK 1238
Query: 498 IYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRK---FKGREEFLKKLTQ-GEVAAGMVLQK 553
+ + + K + + +++E+ ++ +G L+ Q + +L++
Sbjct: 1239 LTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLER 1298
Query: 554 KLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLN 609
L E++ L+ K L R +L +++ +SL +H+ LN
Sbjct: 1299 CLKGEGEIEKLQTKVLELQR--------KLDNTTAAVQELGRENQSLQIKHTQALN 1346
Score = 45.1 bits (105), Expect = 3e-04
Identities = 58/288 (20%), Positives = 126/288 (43%), Gaps = 31/288 (10%)
Query: 107 ESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETL 166
E ++QE K + +E ++ K+L + S ++E+K +++++ +L +E+++
Sbjct: 1095 EQQLQERCKALQDIQKE--KSLKEKELVNEKSKLAEIEEIKC--RQEKEITKLNEELKSH 1150
Query: 167 LSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQE------LPLAVQKE 220
E+I+ I +L+ DA++ L QQ+ + K DS QE L V+KE
Sbjct: 1151 KLESIKEITNLK----DAKQLLIQQKLE---LQGKADSLKAAVEQEKRNQQILKDQVKKE 1203
Query: 221 HEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQE 280
E + IE + L ++++ E + EE AK+ I +NE+
Sbjct: 1204 EEELKKEFIEKEAKLH---SEIKEKEVGMKKHEENEAKLTMQITALNEN----------- 1249
Query: 281 LQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAY 340
L +K ++ + K ++L + E Q + + + + E IE
Sbjct: 1250 LGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKL 1309
Query: 341 KREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHS 388
+ ++ +L D+ +++V + + + + T+A+ + NE+ +
Sbjct: 1310 QTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQN 1357
>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
sapiens]
Length = 709
Score = 85.1 bits (209), Expect = 3e-16
Identities = 155/696 (22%), Positives = 294/696 (42%), Gaps = 109/696 (15%)
Query: 186 EALKQQRSRKNMINMKIDSWSVWKLQELPLAVQK------EHEAYLSDVIELQWHLEDKA 239
+ KQQ+ K +N+ D+ +++ + K E A + +L+ LE
Sbjct: 42 QRFKQQKESKQNLNVDKDTTLPASARKVKSSESKIRVLLQERGAQDRRIQDLETELEKME 101
Query: 240 NQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQ------------ELQDLKNH 287
+L ++KT L NA ++ + + LL SK ++ EL L+N
Sbjct: 102 ARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNK 161
Query: 288 YKKKMEVMDLHRKVNE-ELEEALEACENARLKAQQI--------KEEIDKDIYQDEKTIE 338
+ KM M ++ E +L+ + E ++ K Q+ KE+ID+ + EK +E
Sbjct: 162 RETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS-ETEKLLE 220
Query: 339 AYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRR 398
Y EI + + Y + + N++EK +E+ +S + + LSK +EDL
Sbjct: 221 -YIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSL---KQSLEENIVILSKQVEDLNV 276
Query: 399 VYDQLTWKQKSHENQYLEAVNDFYAA----KKTWDIELSDVAKDFSAISLACTKLTEDNK 454
L +++ H N+ E + A K+ + +E + K L L + K
Sbjct: 277 KCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREK-LQQKELQIDSLLQQEK 335
Query: 455 KLEIDIN-KITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTK 513
+L ++ K+ E +++K+ +E E+K T+ +L DK L+ ++A R L K
Sbjct: 336 ELSSSLHQKLCSFQEEMVKEKNLFEEELKQ-TLDEL--DK-LQQKEEQAER------LVK 385
Query: 514 HKTDEMEDKIAEVR---RKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALE--RKE 568
+E + + E++ K KG+E L+K + A ++LQ+K S+ VQ+LE +
Sbjct: 386 QLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM--VQSLEDVTAQ 443
Query: 569 LIKNRAICAMSLAELQEPLLQLEDEAERI--RSLDKEHSVMLNNIIDQKDLIRRKVGKVK 626
+A+ A + +L+ L+++A + + D +H ++ +Q + +R +
Sbjct: 444 FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ-EYVRMLLDL-- 500
Query: 627 KKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFD 686
+T AL ETE K T+ F KI +L +LK +EE+ F
Sbjct: 501 --------QTKSALKETEIKEI------------TVSFLQKITDLQNQLKQQEED---FR 537
Query: 687 QTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQ 746
+ LE + + EK++ + EE ++R+L + Q
Sbjct: 538 KQLEDEEGR------------------KAEKENTTAELTEEINKWRLLYEELYNKTKPFQ 579
Query: 747 KIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDK-KQLCQLQRRMH 805
+ E L E+ Q K +D+Y + Q +++ K K + +L+
Sbjct: 580 LQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ-----NLKQKIKHVVKLKDENS 634
Query: 806 TLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAVQ 841
L E KL ++ + + +T QE + K+L ++
Sbjct: 635 QLKSEVSKLRCQLAKKKQS--ETKLQEELNKVLGIK 668
Score = 55.8 bits (133), Expect = 2e-07
Identities = 107/624 (17%), Positives = 256/624 (41%), Gaps = 105/624 (16%)
Query: 103 IQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSV----TTPVKEVKPGEKRDEK--- 155
IQD+E+++++ R + E + S+ E + T + + K E ++K
Sbjct: 90 IQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLR 149
Query: 156 -----CPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSR------------KNMI 198
+L+ + ET + + + +E + +L++ + + K I
Sbjct: 150 ILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKI 209
Query: 199 NMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAK 258
+ K ++ + + E + E Y D+ +L+ +L++K +++ K LEE
Sbjct: 210 DEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSL---KQSLEENIVI 266
Query: 259 IQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLK 318
+ ++ +N LL+ K+K + ++ +R+ NE L ++ + +
Sbjct: 267 LSKQVEDLNVKCQLLE--------------KEKEDHVNRNREHNENLNAEMQNLKQKFIL 312
Query: 319 AQQIKEEIDK------DIYQDEKTIE--------AYKREIYQLNSLFDHYSSSVINVNTN 364
QQ +E++ + + Q EK + +++ E+ + +LF+ ++
Sbjct: 313 EQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 372
Query: 365 IEEKEEEVTEAIR----ETKSSKNELHSLSKM-------LEDLRRVYDQLTWKQKSHENQ 413
+++KEE+ ++ E KS EL L + LE + Q T + +
Sbjct: 373 LQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDS 432
Query: 414 YLEAVND----FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNE 469
++++ D F + K E+ D+ + S++ K ++ + ++ I E
Sbjct: 433 MVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQE 492
Query: 470 SIR-------KKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDK 522
+R K + E+EIK +T+ L+ L+N K+ + ++ +
Sbjct: 493 YVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQ-------------QEEDFRKQ 539
Query: 523 IAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYS---IYEVQ----ALERKELIKNRAI 575
+ + + +E +LT+ E+ +L ++LY+ +++Q +E++ L+
Sbjct: 540 LEDEEGRKAEKENTTAELTE-EINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGA 598
Query: 576 CAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKK 635
L ++++ +L + + +H V L D+ ++ +V K++ +L K KK
Sbjct: 599 AQEQLNKIRDSYAKLLGHQNLKQKI--KHVVKLK---DENSQLKSEVSKLRCQLAK--KK 651
Query: 636 TLDALIETESKRSAIFKDLEATKS 659
+ ++ E + K + +K+
Sbjct: 652 QSETKLQEELNKVLGIKHFDPSKA 675
Score = 47.0 bits (110), Expect = 8e-05
Identities = 68/338 (20%), Positives = 141/338 (41%), Gaps = 20/338 (5%)
Query: 528 RKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPL 587
RK K E ++ L Q A +Q + +++A L + ++ A + A L++ L
Sbjct: 67 RKVKSSESKIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANN-ATLEKQL 125
Query: 588 LQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKR 647
++L E ++S E+ N I +L+ K++ K K + + E K
Sbjct: 126 IELTRTNELLKSKFSENGNQKNLRILSLELM-----KLRNKRETKMRGMMAKQEGMEMKL 180
Query: 648 SAIFKDLEATKSKTMIFYAKINELNEE-LKAKEEEKKSFDQTLEILKNKFITMRFKREHA 706
+ LE ++ K K+ + +E + K E +K + EI ++K + A
Sbjct: 181 QVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIA 240
Query: 707 QTVF------DHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLA 760
Q D + K+ EE I ++ L Q ++ + + + E N L
Sbjct: 241 QLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN 300
Query: 761 QEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKKQL-CQLQRRMHTLWQEHFKLVVLFS 819
E Q L+ F+ E+ + K+L +D+ ++ +K+L L +++ + +E K LF
Sbjct: 301 AEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE 360
Query: 820 QM------RLANFQTDSQESIQKILAVQEESSNLMQHI 851
+ L Q +++ + + ++EE+ + + +
Sbjct: 361 EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL 398
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 84.7 bits (208), Expect = 3e-16
Identities = 166/814 (20%), Positives = 355/814 (43%), Gaps = 115/814 (14%)
Query: 98 KMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCP 157
+++ ++++V S+ QE + E E+ S+TKD TT + + +EK
Sbjct: 1290 ELLPNVKEV-SETQETMNELELLTEQ----STTKDS------TTLARIEMERLRLNEKFQ 1338
Query: 158 ELKQEMETLLSEA--IRLIK-SLETDRADAEEALKQ--------QRSRKNMINMKIDSWS 206
E ++E+++L E ++ IK +LE +E +++ Q ++ +NMK
Sbjct: 1339 ESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNE 1398
Query: 207 VWKLQELPLAVQKEHEAYLSDVIE---LQWHLEDKANQLQHFEKQKTELEEANAKIQADI 263
K+ + + A L IE L L++ ++++ K+K +L+ +Q++
Sbjct: 1399 TTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSES 1458
Query: 264 DYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIK 323
D + E+ + +K + ++LK + E + ++ L E + + + I
Sbjct: 1459 DQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIN 1518
Query: 324 EEID---KDIYQDE-----KTIEAYKREIYQLNSLFDH----------YSSSVINVNTNI 365
+++ ++IY+ E K I + ++ +L +H S ++ + +
Sbjct: 1519 DKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRL 1578
Query: 366 EEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQK-SHENQY----LEAVND 420
+E +EE+ I+E + K +L + L+ ++ K K S E +Y + AVN+
Sbjct: 1579 QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNE 1638
Query: 421 FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESE 480
+K +IE + + F L + +N I + +I + E +R +K +
Sbjct: 1639 --TQEKMCEIE--HLKEQFETQKLNLENIETEN----IRLTQILHENLEEMRSVTKERDD 1690
Query: 481 IKYL-TIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKK 539
++ + +K++ D+ +N+ + T + E ++++ V K +E + K
Sbjct: 1691 LRSVEETLKVERDQLKENLRE-----------TITRDLEKQEELKIVHMHLKEHQETIDK 1739
Query: 540 LTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPL----LQLEDEAE 595
L G+V +K E+ +++ N A+ A L ++QE L + L+++ E
Sbjct: 1740 L------RGIVSEK----TNEISNMQKDLEHSNDALKAQDL-KIQEELRIAHMHLKEQQE 1788
Query: 596 ---RIRSLDKEHSVMLNNIIDQKDL------IRRKVGKVKKK------LRKKGKKTLDAL 640
++R + E + L+N+ QKDL ++ K+ ++K L+K +T +
Sbjct: 1789 TIDKLRGIVSEKTDKLSNM--QKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKV 1846
Query: 641 IETESKRSAIFKDLEATKSKTMI----FYAKINELNEELKAKEEEKKSFDQTLEILKNKF 696
E E + I KD T SK I K++E EE+K+ +E+ + + E LK +
Sbjct: 1847 SEMEQLKKQI-KDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLER 1905
Query: 697 ITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRF-RVLLAVRQKTLQ--DTQKIIADSL 753
++ + + QE K E + ++ + +KT+Q D QK + S
Sbjct: 1906 DQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSK 1965
Query: 754 EENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHF- 812
+E + QE Q+ ++ L+ K++ N+ K+++ + KKQ M ++ ++F
Sbjct: 1966 DELQKKIQELQKKELQLLRVKED-VNMSHKKINEMEQL--KKQFEAQNLSMQSVRMDNFQ 2022
Query: 813 ---KLVVLFSQMRLANFQTDSQESIQKILAVQEE 843
KL ++R+ + D I++ L ++ +
Sbjct: 2023 LTKKLHESLEEIRIVAKERDELRRIKESLKMERD 2056
Score = 78.2 bits (191), Expect = 3e-14
Identities = 158/736 (21%), Positives = 311/736 (42%), Gaps = 106/736 (14%)
Query: 160 KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQK 219
K+EME +K E + D EAL+++ + + + + ++ L + +
Sbjct: 521 KEEME---------LKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQ 571
Query: 220 EHEAYLSDVIELQWHLEDKANQLQHF-EKQKTELEEANAKIQADIDYMNEHGPLLDSKQN 278
+ E LS +EL ED+ +LQ + + QK E I+ D+ Y E + D KQ
Sbjct: 572 DLENELSSKVELLREKEDQIKKLQEYIDSQKLE------NIKMDLSYSLES--IEDPKQM 623
Query: 279 QE---------LQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKD 329
++ L + + E ++L K+ +EL + EN ++ Q + E K
Sbjct: 624 KQTLFDAETVALDAKRESAFLRSENLELKEKM-KELATTYKQMEND-IQLYQSQLEAKKK 681
Query: 330 IYQD-EKTIEAYKREIYQLNSLFDHYSSSVINVNTNIE----------EKEEEVTEAIRE 378
+ D EK +++ EI +L SL D + N +E KE E EA+RE
Sbjct: 682 MQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALRE 741
Query: 379 TKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKD 438
+EL SL +E LR+ + KS E + + D S+V
Sbjct: 742 EVILLSELKSLPSEVERLRKEI-----QDKSEELHIITSEKDKL---------FSEVVHK 787
Query: 439 FSAISLACTKL--TEDNKKLEIDINKITVKTNESIRK-KSKYESEIKYLTIMKLKNDKHL 495
S + ++ T+D+ K T + ++ + +E + K + + ++ +
Sbjct: 788 ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEI 847
Query: 496 KNIYKEAYR----IGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVL 551
N+ KEA + +G L +KT E+++K EV+ + E+ ++L + V
Sbjct: 848 VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVE 907
Query: 552 QKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLL----QLEDEAERIRSLDKEHSVM 607
++K ++Q + E +K L +LQE L QL+ + +++ +
Sbjct: 908 REKTLITEKLQ--QTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQ 965
Query: 608 LNNIIDQKDLIRRKVGKVKKKLRKKGKKTL-------DALIETESKRSAIFK--DLEATK 658
L N ++ + + +K K+ ++ + L + E + K I K DLEA
Sbjct: 966 LRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKN 1025
Query: 659 SKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKK 718
++T+ K NE+ E+++K F E KN+ ++ ++V Q K
Sbjct: 1026 TQTLTADVKDNEI------IEQQRKIFSLIQE--KNEL------QQMLESVIAEKEQLKT 1071
Query: 719 DCEERI---FEEDQRFRVLLAVRQKTLQDTQKIIAD----SLEENLRLAQEYQQLQITFL 771
D +E I E + R+L L+ Q+I+A ++++ L++ +L
Sbjct: 1072 DLKENIEMTIENQEELRLL----GDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE 1127
Query: 772 KEKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQ 831
K K+ + +KQ L + ++++ ++Q++++ + E+ K + ++ L + +T+
Sbjct: 1128 KLKEKSQQLQEKQQQL---LNVQEEMSEMQKKINEI--ENLKNELKNKELTLEHMETERL 1182
Query: 832 ESIQKILAVQEESSNL 847
E QK+ EE ++
Sbjct: 1183 ELAQKLNENYEEVKSI 1198
Score = 69.3 bits (168), Expect = 1e-11
Identities = 149/730 (20%), Positives = 299/730 (40%), Gaps = 122/730 (16%)
Query: 226 SDVIELQWHLEDKANQLQHFEKQK----TELEEANAKIQADIDYMNEHGPLLDSKQN--- 278
S+V L+ ++DK+ +L +K +E+ +++Q ++ + + L + Q+
Sbjct: 754 SEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYK 813
Query: 279 ---QELQDLKNHY----KKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEID-KDI 330
QE Q+ K + +K V++ + ++N+E+ + + +K E+ K
Sbjct: 814 STDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQ 873
Query: 331 YQDEKTIEAYKR--EIYQLNSLFDHYSSSVINV---NTNIEEKEEEVTEAIRETKSSKNE 385
EKT E +R E+ QL ++ S++ V T I EK ++ E ++ K++
Sbjct: 874 ELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDD 933
Query: 386 LHSLSKML----------------------EDLRRVYDQL--------TWKQKSHE--NQ 413
L L + L E LR + L T K K E ++
Sbjct: 934 LKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSR 993
Query: 414 YLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEI------------DIN 461
L + K + ++ + K + LT D K EI + N
Sbjct: 994 NLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKN 1053
Query: 462 KITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEME- 520
++ I +K + ++++K M ++N + L+ + E + + K+ + E
Sbjct: 1054 ELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEG 1113
Query: 521 ------DKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRA 574
D++AEV K K + + L++ Q + + + I E++ L K +KN+
Sbjct: 1114 ELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENL--KNELKNKE 1171
Query: 575 ICAMSL-AELQEPLLQLEDEAERIRSLDKEHSV---MLNNIIDQKDLIRRKVGKV----- 625
+ + E E +L + E ++S+ KE V + + ++D +R + ++
Sbjct: 1172 LTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGL 1231
Query: 626 --KKKLR------KKGKKTLDALIETESKRSA-IFKDLEATKSKTMIFYAKINELNEELK 676
K++L+ K+ ++T+D L + S+++A I + KS T +L EE+
Sbjct: 1232 QTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHT--------KLQEEIP 1283
Query: 677 AKEEEK------KSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQR 730
EE+ K +T E + + T E+ E+ E +
Sbjct: 1284 VLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEE 1343
Query: 731 FRVLLAVRQ--KTLQDTQKIIADSLEENLR--LAQ----EYQQLQITFLKEKDNYFNIYD 782
+ L R KT+++ ++ D L+E++R LA+ + +Q Q +KEKDN
Sbjct: 1344 IKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETT--- 1400
Query: 783 KQLSLDTSIRDK-KQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAVQ 841
K +S + K L +++ M L + +L +M+ + D + +Q++L Q
Sbjct: 1401 KIVSEMEQFKPKDSALLRIEIEMLGLSK---RLQESHDEMKSVAKEKDDLQRLQEVL--Q 1455
Query: 842 EESSNLMQHI 851
ES L ++I
Sbjct: 1456 SESDQLKENI 1465
Score = 67.0 bits (162), Expect = 7e-11
Identities = 144/743 (19%), Positives = 318/743 (42%), Gaps = 102/743 (13%)
Query: 96 VNKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEK 155
++ M +++ +K+QE ++ + + E + KD+ E + ++++K + +D+
Sbjct: 1804 LSNMQKDLENSNAKLQEKIQELKAN--EHQLITLKKDVNETQKKVSEMEQLKK-QIKDQS 1860
Query: 156 CPELKQEMETL-----LSEAIRLIKSLETDRAD---AEEALKQQRSRKNMINMKIDSWSV 207
K E+E L L E + +KS+ +R + EE LK +R + + + +
Sbjct: 1861 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL 1920
Query: 208 WKLQELPLA--VQKEHEAYLSDVIELQWHLEDKANQL----QHFEKQKTELEEANAKIQA 261
QEL A + KEH+ V +L+ + +K Q+ + +K K EL++ ++Q
Sbjct: 1921 EIQQELKTARMLSKEHK---ETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQK 1977
Query: 262 -DIDYMNEHGPL-LDSKQNQELQDLKNHYKK--------KMEVMDLHRKVNEELEE---- 307
++ + + + K+ E++ LK ++ +M+ L +K++E LEE
Sbjct: 1978 KELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIV 2037
Query: 308 ALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEE 367
A E E R+K + +K E D+ I + I A R+ +Q+ S ++ ++ E
Sbjct: 2038 AKERDELRRIK-ESLKMERDQFIATLREMI-ARDRQNHQVKPEKRLLSDGQQHLTESLRE 2095
Query: 368 KEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYD---QLTWKQKSHEN-QYLEA--VNDF 421
K + E ++ + L+++ DL + + +L+ + K++ + YL+ +
Sbjct: 2096 KCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKL 2155
Query: 422 YAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEI 481
+ A + +E + K + TK+ E+ + INK + + + K+ + +I
Sbjct: 2156 FTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHE---SINKFEMDFIDEVEKQKELLIKI 2212
Query: 482 KYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLT 541
++L + L+++ H+ + D E + ++ +F+ K++T
Sbjct: 2213 QHLQQDCDVPSRELRDLKLNQ---NMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMT 2269
Query: 542 QGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMS-------------LAELQEPLL 588
Q L++ L + ++++ L+ +N IC ++ E +E
Sbjct: 2270 Q-------FLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSA 2322
Query: 589 QLEDEAER-IRSLDKEHSVMLNNIIDQKDLIR-------------------RKVGKVKKK 628
+ E E+ ++SL +++ + N K + R +K
Sbjct: 2323 TISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEK 2382
Query: 629 LRKKGKKTLDA---LIETESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSF 685
+R+ +A + ESK + K+LE T AK++E N+ L+ +E
Sbjct: 2383 IRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKE----- 2437
Query: 686 DQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDT 745
T+++L++K + + + + D M+ K E++ + + F ++ + T+ +
Sbjct: 2438 --TIQVLQDK--VALGAKPYKEEIEDLKMKLVKIDLEKM-KNAKEFEKEISATKATV-EY 2491
Query: 746 QKIIADSLEENLRLAQEYQQLQI 768
QK + L ENLR +Q+ Q +
Sbjct: 2492 QKEVIRLLRENLRRSQQAQDTSV 2514
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 84.3 bits (207), Expect = 4e-16
Identities = 147/749 (19%), Positives = 320/749 (42%), Gaps = 102/749 (13%)
Query: 158 ELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAV 217
EL+Q++E L EA RL + + + A Q+ ++ +++ + +LQE+ + +
Sbjct: 474 ELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERE--RLQEMLMGL 531
Query: 218 QKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQ 277
+ + LS++I L+ LE + + +++TE+ A A+ + I ++ L +
Sbjct: 532 EAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKT-- 589
Query: 278 NQELQDLKNHYKK--------KMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKD 329
E+ DL+ K ++ + L++++ + EE C A+Q + + D
Sbjct: 590 --EVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA-AEQARNALQVD 646
Query: 330 IYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSL 389
+ + EK EA + L + + + ++ + +EE E ++ S+++ +
Sbjct: 647 LAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAA 706
Query: 390 SKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYA---AKKTWDIEL-------SDVAKDF 439
+ LE QL + K E AV + A K ++ L D+A+
Sbjct: 707 TTQLE-------QLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQL 759
Query: 440 SAISLACTKL-------TEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKND 492
+S A L + N +E+ ++ V+ + K + E++ L KL+ D
Sbjct: 760 QGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCL---KLELD 816
Query: 493 KHLKNIYKE----AYRIGTLFHLTKHKTDEM----EDKIAEVRRKFKGREEF-------- 536
+E A ++ K ++ E ++ ++R K++ +
Sbjct: 817 TERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKA 876
Query: 537 LKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIK-NRAICAMSL------AELQEPLLQ 589
L+ L + ++ M L+++ + +QA +E + A+C M L L E LLQ
Sbjct: 877 LESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQ 936
Query: 590 ----LEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETES 645
L D ++++ L ++ V + +++ ++ + +++L++ ++ D L +
Sbjct: 937 TQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQE 996
Query: 646 KRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREH 705
+ S++ +D M ++ +L +L A+++ ++ +Q E+ + T + R
Sbjct: 997 ESSSLLQD-------KMDLQKQVEDLKSQLVAQDDSQRLVEQ--EVQEKLRETQEYNR-- 1045
Query: 706 AQTVFDHYMQEKKDCEERIFEEDQRFRVLL---AVRQKTLQDTQKIIADSLEENLRLAQE 762
+ +EK + E++QR VL ++RQ+ L ++ + ++ E L+ +
Sbjct: 1046 ---IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQ 1102
Query: 763 YQQLQITFLKEKDNYFNIYDKQL--SLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQ 820
+ L+ +KEK+ F + QL L+ S ++QL +LW + K L Q
Sbjct: 1103 MELLR-QEVKEKEADFLAQEAQLLEELEASHITEQQL------RASLWAQEAKAAQL--Q 1153
Query: 821 MRLANFQTDSQESIQKILAVQEESSNLMQ 849
+RL S ES + LA +++ N Q
Sbjct: 1154 LRLR-----STESQLEALAAEQQPGNQAQ 1177
Score = 78.2 bits (191), Expect = 3e-14
Identities = 143/731 (19%), Positives = 297/731 (40%), Gaps = 136/731 (18%)
Query: 169 EAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDV 228
+A+ L++S+ T R A + L+QQ + QE +Q++H+
Sbjct: 386 KALTLVRSVLTRRRQAVQDLRQQLAG---------------CQEAVNLLQQQHD------ 424
Query: 229 IELQWHLEDKA--NQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKN 286
QW E KA +LQ ++ L +Q ++D +++ LL
Sbjct: 425 ---QWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELL------------- 468
Query: 287 HYKKKMEVMDLHRKVNEELEEALEACE---------NARLKAQQIKEEIDKDIYQDEKTI 337
+K EEL + LE E N L+ Q + K+ Q+E +
Sbjct: 469 ------------QKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHL 516
Query: 338 EAYKREIYQ-----LNSLFDHYSSSVINVNTNIE----------EKEEEVTEAIRETKSS 382
+RE Q L + S +I + +E +++ EVT A+ + S
Sbjct: 517 AVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQS 576
Query: 383 KNELHSLSKMLE----DLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKT-WDIELSDVAK 437
EL S L+ DLR +L+ A+N+ A K + +L + +
Sbjct: 577 IAELSSSENTLKTEVADLRAAAVKLS------------ALNEALALDKVGLNQQLLQLEE 624
Query: 438 DFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKN 497
+ ++ + L++D+ + + K + E++++ + L++
Sbjct: 625 ENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRD 684
Query: 498 IYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYS 557
I +E I ++H+ + ++ ++ ++ K +EE L + Q + A ++++K
Sbjct: 685 IQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEA---LVREKAAL 741
Query: 558 IYEVQALERKELIKNRAICAMSLAE--LQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQK 615
+QA+ER + +S A+ L+ L + + + I + V + + K
Sbjct: 742 EVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAK 801
Query: 616 DLIRRKVGKVKKKL---RKKGKKTLDA----LIETESKRSAIFKDLEATKSKTMIFYAKI 668
++I+ +V +K +L R + ++ DA L + E + + +A K ++
Sbjct: 802 EVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEK------EV 855
Query: 669 NELNEEL-KAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKD-------- 719
N+L E+ K + ++ + LE L+ + + + + + QT + ++++
Sbjct: 856 NQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESA 915
Query: 720 -CEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDN-- 776
C+ ++ E +R +L +TL TQK +AD+ ++ RL Q+ +++ LKE++
Sbjct: 916 LCQMQLETEKERVSLL-----ETLLQTQKELADASQQLERLRQD---MKVQKLKEQETTG 967
Query: 777 --YFNIYDKQLSLDTSIRD-KKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANF-QTDSQE 832
+ + Q L + R + L LQ +L Q+ L ++ Q DSQ
Sbjct: 968 ILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQR 1027
Query: 833 SIQKILAVQEE 843
+++ VQE+
Sbjct: 1028 LVEQ--EVQEK 1036
Score = 67.8 bits (164), Expect = 4e-11
Identities = 126/717 (17%), Positives = 294/717 (41%), Gaps = 65/717 (9%)
Query: 158 ELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWK-----LQE 212
E ++E+ETL + L K E +A E + R ++++ + + L+
Sbjct: 1432 EREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEH 1491
Query: 213 LPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPL 272
LP+AVQ+ + +++ +D+ Q E Q ELE+ + I++ + +
Sbjct: 1492 LPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQ 1551
Query: 273 LDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQ 332
L + + L+ +NH+K M+ +K+ +ELE E A + D+ +
Sbjct: 1552 LVTLECLALELEENHHK-----MECQQKLIKELEGQRETQRVA-------LTHLTLDLEE 1599
Query: 333 DEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKM 392
+ ++A +I+ L S + + + ++ + E++ E R+ + +L +
Sbjct: 1600 RSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQE 1659
Query: 393 LEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTED 452
L L++ Q+ Q++ + + LE D K + L + ++ + + E+
Sbjct: 1660 LM-LQKERIQVLEDQRTRQTKILE--EDLEQIK----LSLRERGRELTTQRQLMQERAEE 1712
Query: 453 NK------KLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIG 506
K + ++ K+ ++ E ++ + I L +K + ++ L+ ++++
Sbjct: 1713 GKGPSKAQRGSLEHMKLILRDKE--KEVECQQEHIHELQELKDQLEQQLQGLHRKVGETS 1770
Query: 507 TLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIY--EVQAL 564
L + + ++ ++ E R + + +E+ L+ A ++L ++ + QA
Sbjct: 1771 LLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQ 1830
Query: 565 ERKELIKNRAICAMSLAE-----LQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIR 619
++E +K +A E L+E +L+D E+ R L++E +V + +
Sbjct: 1831 GQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRV----QALE 1886
Query: 620 RKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKE 679
+G ++ + R++ K L + + + A + + A + E ++EL+A
Sbjct: 1887 EVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALR 1946
Query: 680 EEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLA--- 736
E +S E R + E Q + E+ + E+ + R L A
Sbjct: 1947 AESQSSRHQEE-------AARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTA 1999
Query: 737 ----------VRQKTLQDTQKIIADSL-EENLRLAQEYQQLQITFLKEKDNYFNIYDKQL 785
+ L++ +I + +++LR ++ QQLQ + + + +++
Sbjct: 2000 TLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQ 2059
Query: 786 SLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAVQE 842
L+ S+ + Q +Q + + L QE + + + Q + Q+IL ++E
Sbjct: 2060 LLEKSLAQRVQENMIQEKQN-LGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRE 2115
Score = 45.4 bits (106), Expect = 2e-04
Identities = 139/748 (18%), Positives = 287/748 (38%), Gaps = 142/748 (18%)
Query: 222 EAYLSD-VIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQE 280
+A L D V EL L Q + +EK L E ++ + + EH L +E
Sbjct: 278 KAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEE 337
Query: 281 LQDLKNHYKKKMEVM------------------------------------DLHRKVNEE 304
L+ K +VM L R V
Sbjct: 338 KLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTR 397
Query: 305 LEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTN 364
+A++ Q+ + + Q E+ +A ++ + +L D + +++
Sbjct: 398 RRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGE 457
Query: 365 IE--EKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFY 422
++ KE E+ + RE + +L L + LRRV +L + S + Q E + +
Sbjct: 458 VDSLSKERELLQKARE--ELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELH 515
Query: 423 AA----KKTWDIELSDVAKDFSAIS-LACTKLTEDNKKLE--------IDINKITVKTNE 469
A ++ ++ + AK ++S L + ++ LE ++ + +
Sbjct: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575
Query: 470 SIRKKSKYESEIK------------------YLTIMKLKNDKHLKNIYKEAYRIGTLFHL 511
SI + S E+ +K L + K+ ++ L + +E + +
Sbjct: 576 SIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA 635
Query: 512 TKHKTDEMEDKIAEVRRKFKG---REEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKE 568
+ + ++ +AE ++ + + L+ Q AG LQ L I E + +K+
Sbjct: 636 AEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKK 695
Query: 569 LIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVG-KVKK 627
L ++R + +L+ QL EA+R + V+ + +++ L+R K +V+
Sbjct: 696 LSESRHQQEAATTQLE----QLHQEAKR------QEEVLARAVQEKEALVREKAALEVRL 745
Query: 628 KLRKKGKKTLDALIE-----TESKRSAIFKD------LEATKSKTMIFYAKIN------- 669
+ ++ ++ L ++ E S++F+ +E TK + + +
Sbjct: 746 QAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQ 805
Query: 670 --------ELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCE 721
EL+ E E+E+ + + L + + T +++ A + ++EK + E
Sbjct: 806 GEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKE 865
Query: 722 E--------RIFEEDQRFRVLLAVRQKTLQ-DTQKIIADSLEENLRLAQEYQQLQITFLK 772
+ E +R ++ L +R K Q + + I A EE + Q+Q+ K
Sbjct: 866 RSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEK 925
Query: 773 EKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQE 832
E+ + L+T ++ +K+L +++ L Q+ K+ L Q QT QE
Sbjct: 926 ERVSL---------LETLLQTQKELADASQQLERLRQD-MKVQKLKEQETTGILQTQLQE 975
Query: 833 SIQK-----------ILAVQEESSNLMQ 849
+ ++ + A+QEESS+L+Q
Sbjct: 976 AQRELKEAARQHRDDLAALQEESSSLLQ 1003
Score = 43.5 bits (101), Expect = 8e-04
Identities = 95/488 (19%), Positives = 192/488 (39%), Gaps = 82/488 (16%)
Query: 154 EKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQEL 213
++C E QE E ++L+ A+ LK++ + + ++ +S S +E
Sbjct: 1908 QQCAEQAQEHEVET-------RALQDSWLQAQAVLKERD--QELEALRAESQSSRHQEE- 1957
Query: 214 PLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLL 273
A + EA + + L+ K L + LE + A +QA +D H L
Sbjct: 1958 --AARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQL 2015
Query: 274 DSK---QNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDI 330
+ Q E+QD Y++ +V L + + + EE E +L + + + + +++
Sbjct: 2016 EEALRIQEGEIQDQDLRYQE--DVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENM 2073
Query: 331 YQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKN-----E 385
Q+++ + +RE ++ L SV + + +KE+E+ E +RET+ N
Sbjct: 2074 IQEKQNL-GQEREEEEIRGLHQ----SVRELQLTLAQKEQEILE-LRETQQRNNLEALPH 2127
Query: 386 LHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLA 445
H S M E ++ D L + + + A+ A + W + D+A +SLA
Sbjct: 2128 SHKTSPMEEQSLKL-DSLEPRLQRELERLQAALRQTEAREIEWREKAQDLA-----LSLA 2181
Query: 446 CTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRI 505
TK + S + +L L+ D + + E
Sbjct: 2182 QTKASV-----------------------SSLQEVAMFLQASVLERDSEQQRLQDE---- 2214
Query: 506 GTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALE 565
LT+ ++ R G + ++GE +L + V+A
Sbjct: 2215 ---LELTRRALEKE-------RLHSPGATSTAELGSRGEQGV------QLGEVSGVEAEP 2258
Query: 566 RKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKV 625
+ ++ ++ L LQ+ + +LE + R++ H+V L + ++Q + RRK+ +
Sbjct: 2259 SPDGMEKQS-WRQRLEHLQQAVARLEIDRSRLQ----RHNVQLRSTLEQVERERRKLKRE 2313
Query: 626 KKKLRKKG 633
+ + G
Sbjct: 2314 AMRAAQAG 2321
Score = 36.6 bits (83), Expect = 0.10
Identities = 72/378 (19%), Positives = 157/378 (41%), Gaps = 50/378 (13%)
Query: 334 EKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKML 393
EK +E+ QL S D + E ++ VTE S+ + KM+
Sbjct: 257 EKEAHERSQELIQLKSQGDLEKA----------ELQDRVTELSALLTQSQKQNEDYEKMI 306
Query: 394 EDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDN 453
+ LR + L +++ + +E + + L V KD + + + E +
Sbjct: 307 KALRETVEIL----ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVE-----EGD 357
Query: 454 KKLEIDINKITVKTNESIRKKSKYESEIKYLTIMK---LKNDKHLKNIYKEAYRIGTLFH 510
+ ++ +++ + SI + Y+ K LT+++ + + ++++ ++ +
Sbjct: 358 NIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVN 417
Query: 511 LTKHKTDEMEDKIAEVRRKFKGREEFLKKLT-QGEVAAGMVLQKKLYSIYEVQALERKEL 569
L + + D+ E++ +R++ L+KLT + + AG + ++Q E L
Sbjct: 418 LLQQQHDQWEEEGKALRQR-------LQKLTGERDTLAGQTV--------DLQG-EVDSL 461
Query: 570 IKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKD-------LIRRKV 622
K R + + EL++ L LE EA R+R ++ E + ++ QK+ L R+
Sbjct: 462 SKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRER 521
Query: 623 GKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEK 682
++++ L K ++L E + R A LE++ + + + E+ L E+
Sbjct: 522 ERLQEMLMGLEAKQSESLSELITLREA----LESSHLEGELLRQEQTEVTAALARAEQSI 577
Query: 683 KSFDQTLEILKNKFITMR 700
+ LK + +R
Sbjct: 578 AELSSSENTLKTEVADLR 595
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 84.0 bits (206), Expect = 6e-16
Identities = 154/692 (22%), Positives = 287/692 (41%), Gaps = 122/692 (17%)
Query: 144 KEVKPGEKRDEKCPELKQEMETLLSEA---IRLIKSLETDRADAEEALKQQRSRK----- 195
K+++ E+ ++ ++ +E E LL + +KS T + L +Q K
Sbjct: 1552 KDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELH 1611
Query: 196 ----NMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIE--------LQWHLEDKANQLQ 243
+M+ K D +L E + + H + ++E L + ++ QL
Sbjct: 1612 LLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLT 1671
Query: 244 HFEKQKTELEEANAKIQADIDYMNEHGP----LLDSKQ--NQELQDLKNHYKKKMEVMDL 297
KQ+ E EE N +Q + M++H +LD Q N ELQ LK + ++ V +L
Sbjct: 1672 LI-KQEIEKEEEN--LQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQR--VSEL 1726
Query: 298 HRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSS 357
+ LEE LE EN + +QQ K EI+ ++ +E KREI ++ +
Sbjct: 1727 EKTQVAVLEEKLEL-ENLQQISQQQKGEIE----WQKQLLERDKREIERMTA-------- 1773
Query: 358 VINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEA 417
E+++ ++ + LSK EDL+ D W++K + + + A
Sbjct: 1774 --------------------ESRALQSCVECLSKEKEDLQEKCD--IWEKKLAQTKRVLA 1811
Query: 418 VNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKY 477
AA++ +E S++ K + L KL ++ +L D K+++ + S ++
Sbjct: 1812 -----AAEENSKMEQSNLEK----LELNVRKLQQELDQLNRD--KLSLHNDISAMQQQLQ 1860
Query: 478 ESEIKYLTIMK-LKNDKHLKNIYKEAYRIGTLFHLTKHKT------DEMEDKIAEVRRKF 530
E ++ + L N + N+ K+ L H TKH+ ++ I+E +F
Sbjct: 1861 EKREAVNSLQEELANVQDHLNLAKQ-----DLLHTTKHQDVLLSEQTRLQKDISEWANRF 1915
Query: 531 KG-REEFLKKLTQGEVAAGMVLQKKLYSIYEVQALER--KELIKNRAICAMSLAELQEPL 587
+ ++E K Q +V + + KL + + +R KE + S L+E
Sbjct: 1916 EDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQ 1975
Query: 588 LQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKR 647
QLE E + DQK + + + KV ++ + L E E
Sbjct: 1976 HQLEKE-----------------LTDQKSKLDQVLSKVLA-----AEERVRTLQEEERWC 2013
Query: 648 SAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQ 707
++ K L TK + ++ E + EL A ++E S +L+N+F+T R K E
Sbjct: 2014 ESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQV 2073
Query: 708 TVFDHYMQ-EKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQL 766
++ ++ E+ + E+ Q + QK + + + D+ E RL +E Q+
Sbjct: 2074 ASLKEALKIQRSQLEKNLLEQKQENSCI----QKEMATIELVAQDNHERARRLMKELNQM 2129
Query: 767 QITFLKEKDNYFNIYD---KQLSLDTSIRDKK 795
Q + + K N D +Q+ + ++R K
Sbjct: 2130 QYEYTELKKQMANQKDLERRQMEISDAMRTLK 2161
Score = 80.9 bits (198), Expect = 5e-15
Identities = 115/602 (19%), Positives = 247/602 (41%), Gaps = 65/602 (10%)
Query: 222 EAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLD------- 274
E +S + ++ HL+ K + + K + E+ ++ +ID + + L+
Sbjct: 1322 ENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELH 1381
Query: 275 ---SKQNQELQDLKNHYKKKMEVMDLHR--KVNEELEEALEACENARLKAQQIKEEIDKD 329
K+ Q+ + + + M +++ + K +E++ + +E E LK + E D+
Sbjct: 1382 RTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRL 1441
Query: 330 IYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSL 389
+ + E + K + F S++ ++ EE E E + +L SL
Sbjct: 1442 LAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSL 1501
Query: 390 SKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKL 449
+DL + K + + L+ +N AAK + DF +S KL
Sbjct: 1502 QADAKDLEQ--------HKIKQEEILKEINKIVAAKDS----------DFQCLSKKKEKL 1543
Query: 450 TEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLF 509
TE+ +KL+ DI + NE + ESE+ L + + +K + + + L
Sbjct: 1544 TEELQKLQKDIE--MAERNEDHHLQVLKESEV-LLQAKRAELEKLKSQVTSQQQEMAVLD 1600
Query: 510 HLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKEL 569
HK +E+ + + +E L +L + EV +++ S+ E + ++ EL
Sbjct: 1601 RQLGHKKEELHLLQGSMVQAKADLQEAL-RLGETEVTEKCNHIREVKSLLEELSFQKGEL 1659
Query: 570 IKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKL 629
+ L +++ + + E+ + + +H L NI+D L ++ +K +
Sbjct: 1660 NVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQH 1719
Query: 630 RKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTL 689
++ + E E + A+ ++ + + +++++ K + E +K Q L
Sbjct: 1720 DQR-------VSELEKTQVAVLEE--------KLELENLQQISQQQKGEIEWQK---QLL 1761
Query: 690 EILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKII 749
E K + M + Q+ + +EK+D +E+ + +K L T++++
Sbjct: 1762 ERDKREIERMTAESRALQSCVECLSKEKEDLQEK-----------CDIWEKKLAQTKRVL 1810
Query: 750 ADSLEENLRLAQ-EYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLW 808
A + EEN ++ Q ++L++ K + + +LSL I +Q Q +R
Sbjct: 1811 A-AAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSL 1869
Query: 809 QE 810
QE
Sbjct: 1870 QE 1871
Score = 58.9 bits (141), Expect = 2e-08
Identities = 147/697 (21%), Positives = 276/697 (39%), Gaps = 116/697 (16%)
Query: 206 SVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDY 265
S+ L+ P+ Q EA+ ++ LE+ + EK+ E EE +K ++
Sbjct: 246 SLESLEGQPVTTQDRQEAFE------RFSLEEVERLERDLEKKMIETEELKSKQTRFLEE 299
Query: 266 MNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQI--- 322
+ L S + + + ++ + K ++ + + ++ E AC+ Q++
Sbjct: 300 IKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFY 359
Query: 323 -------------KEEIDKDIYQDEKTI---EAYKREIYQLNSLFDHYSSSVINVNTNIE 366
E + D DE YKR ++ S +I+ ++
Sbjct: 360 KIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESY-------IIDSAQAVQ 412
Query: 367 EKEEEVTEAIRETKSSKNELHSLSKMLED-----------LRRVYDQLTWKQKSHENQYL 415
K+ E E +R + L LED L ++D++ + E Q L
Sbjct: 413 IKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEI----EKAEQQIL 468
Query: 416 EAVNDFYAAKKTWDI-ELSDVAKDFSAISLA-----CTKLTEDNKKLEIDINKITVKTNE 469
A +F ++ + ++S+ KD L+ KL ++ LE+ + K +
Sbjct: 469 RATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQME----KQKQ 524
Query: 470 SIRKKSKYESEIKYLTI-MKLKNDKHLKNIYKEAYRIG---------TLFHLTKHKTDEM 519
I K K EIK L I + + K K+ + +A + G + + + DE+
Sbjct: 525 EIAGKQK---EIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEI 581
Query: 520 EDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMS 579
+IA+ + K EE +LT+G++AA L+K L + E IK +A A +
Sbjct: 582 LSRIAKETEEIKDLEE---QLTEGQIAANEALKKDLEGVIS-GLQEYLGTIKGQATQAQN 637
Query: 580 ----LAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKK 635
L + +E LLQ E E+ R L + + +R+++ +++ L+++ +
Sbjct: 638 ECRKLRDEKETLLQRLTEVEQERD-------QLEIVAMDAENMRKELAELESALQEQHEV 690
Query: 636 TLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEEL----KAKEEEKKSFDQTLE- 690
+L +T+ SA +LEA + + A+ N+L EEL + + E+ + LE
Sbjct: 691 NA-SLQQTQGDLSAYEAELEA---RLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEK 746
Query: 691 ---ILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQK 747
LKN +F E Q + + + K ++D LL + K Q+
Sbjct: 747 ERQALKNALGKAQFSEEKEQENSELHAKLKH------LQDDNN---LLKQQLKDFQNHLN 797
Query: 748 IIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRD-KKQLCQLQRRMHT 806
+ D L +A +L+ LK NI+ L S+ D +KQ ++ R +
Sbjct: 798 HVVDGLVRPEEVAARVDELR-RKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILAR--S 854
Query: 807 LWQEHFKLVVLFSQMRLANFQTDSQESIQKILAVQEE 843
W+ +Q+R Q + +K+ QEE
Sbjct: 855 KWERD------EAQVRERKLQEEMALQQEKLATGQEE 885
Score = 51.2 bits (121), Expect = 4e-06
Identities = 146/739 (19%), Positives = 302/739 (40%), Gaps = 139/739 (18%)
Query: 107 ESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGE--KRDEKCPELKQEME 164
+ K+ + LK E + S ++LK D + + + K E + +K EL+QE+
Sbjct: 303 QDKLNKSLKE-----EAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELA 357
Query: 165 TLLSEA----IRLIKS--LETDRA-DAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAV 217
+A + S E D+A D + + R ++NM +S+ + Q + +
Sbjct: 358 FYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMF--ATESYIIDSAQAVQIKK 415
Query: 218 QKEHEAYLSDVIELQWH------LEDKANQLQ---------HFEKQKTE----------- 251
+ E +D + L+ H LEDK ++ H E +K E
Sbjct: 416 MEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFK 475
Query: 252 -LEEAN-----AKIQADIDYMNEHGPL-LDSKQNQELQDLKNHYKKKMEVMDLHRKVNEE 304
LEEA ++ D+ Y G L L +K QE DL+ +K+ + + +K ++
Sbjct: 476 QLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKD 535
Query: 305 LEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTN 364
L+ A+++ ++ K +K + E+ ++ ++ QL S D S +
Sbjct: 536 LQIAIDSLDSKDPKHSHMKAQKSGK----EQQLDIMNKQYQQLESRLDEILSRIAKETEE 591
Query: 365 IEEKEEEVTEA-IRETKSSKNELHS-LSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFY 422
I++ EE++TE I ++ K +L +S + E L + Q T Q +E + L +
Sbjct: 592 IKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQAT--QAQNECRKLRDEKETL 649
Query: 423 AAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDI---NKITVKTNESIRKKSKYES 479
+ T E+ +++ + ++ +LE + +++ ++ S YE+
Sbjct: 650 LQRLT---EVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEA 706
Query: 480 EIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKK 539
E++ ++ LK ++ R LT+ + ++ ++ + R+ K
Sbjct: 707 ELEARLNLRDAEANQLKEELEKVTR------LTQLEQSALQAELEKERQALKN------- 753
Query: 540 LTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRS 599
++ + Q E KE +EL L L+D+ ++
Sbjct: 754 -----------------ALGKAQFSEEKE---------QENSELHAKLKHLQDDNNLLKQ 787
Query: 600 LDKEHSVMLNNIID---QKDLIRRKVGKVKKKLR-KKGKKTL----DALIETESKRSAIF 651
K+ LN+++D + + + +V ++++KL+ G+ + D L ++ + F
Sbjct: 788 QLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQF 847
Query: 652 KDLEATKSKTMIFYAKINE--LNEELKAKEEEKKSFDQTLEILKNKFITMRF---KREHA 706
++ A +SK A++ E L EE+ ++E+ + + + + R KR+H
Sbjct: 848 SEILA-RSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHE 906
Query: 707 QTVFD-----HYMQEKKDCEERI---------FEEDQRFRVLLAVRQ----KTLQDTQKI 748
+ HY+QE E I ++++ R+L +R+ K L+D
Sbjct: 907 ARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLED---- 962
Query: 749 IADSLEENLRLAQEYQQLQ 767
A S E+ L +E ++L+
Sbjct: 963 -AKSQEQVFGLDKELKKLK 980
Score = 41.2 bits (95), Expect = 0.004
Identities = 83/431 (19%), Positives = 163/431 (37%), Gaps = 53/431 (12%)
Query: 3 ENKTVSSSSTRDDQTNIGLTCQEVKALREKAWSRTNEGNAMSQSLVLYGASKENSEGFHE 62
EN + S+ + N+ QE+ L S N+ +AM Q L K + +
Sbjct: 1815 ENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQL----QEKREAVNSLQ 1870
Query: 63 SKMTNTEGVNKGIYFSYPCRRHSCAVVNIPAPCVNKMISHIQDV----ESKIQEHLKRFE 118
++ N + +N+ + H QDV ++++Q+ + +
Sbjct: 1871 EELANVQD-----------------HLNLAKQDLLHTTKH-QDVLLSEQTRLQKDISEWA 1912
Query: 119 TSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEM--ETLLSEAIRLIKS 176
FE+ + TK + +V E + K ++QEM + L E
Sbjct: 1913 NRFEDCQKEEETKQQQ---------LQVLQNEIEENKLKLVQQEMMFQRLQKERESEESK 1963
Query: 177 LETDRADAEEALKQQRSRKNMINMKIDS--WSVWKLQELPLAVQKEHEAYLSDVIELQWH 234
LET + +E Q K+D V +E +Q+E S L+
Sbjct: 1964 LETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCES----LEKT 2019
Query: 235 LEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEV 294
L QL E+Q E +Q + D M LL +NQ L + K K+ +
Sbjct: 2020 LSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLL---RNQFLTERKKAEKQVASL 2076
Query: 295 MDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHY 354
+ + +LE+ L + Q+ I+ + + +E+ Q+ +
Sbjct: 2077 KEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTEL 2136
Query: 355 SSSVINVNTNIEEKEEEVTEAIRETKSS-----KNELHSLSKMLEDLRRVYDQLTWKQKS 409
+ N ++E ++ E+++A+R KS + L +L++ L +L + + + ++
Sbjct: 2137 KKQMAN-QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNEN 2195
Query: 410 HENQYLEAVND 420
E + LE++ +
Sbjct: 2196 LEGE-LESLKE 2205
Score = 36.2 bits (82), Expect = 0.14
Identities = 83/405 (20%), Positives = 180/405 (44%), Gaps = 56/405 (13%)
Query: 474 KSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGR 533
KSK E +++ K +++K ++ ++ + I L K +E ++ E+ R + R
Sbjct: 1336 KSKKREE-RWMRASKRQSEKEMEELH---HNIDDLLQEKK----SLECEVEELHRTVQKR 1387
Query: 534 EEFLKKLTQGEVAAGMV---LQKKLYS----IYEVQALERKELIKNRAICAMSLAELQEP 586
++ K G V + M ++K L + E++ +E K L+K R+ EL+E
Sbjct: 1388 QQ-QKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIE-KTLLKRRS-------ELREA 1438
Query: 587 LLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVK---KKLRKKGKKTLDALIET 643
+L EAE S KE + N +++ +R + + + ++L ++ ++T L++
Sbjct: 1439 D-RLLAEAESELSCTKEKT---KNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKA 1494
Query: 644 ESKRSAI---FKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMR 700
+ + ++ KDLE K K + E+N+ + AK+ + + + E L + ++
Sbjct: 1495 DQQLRSLQADAKDLEQHKIKQEEI---LKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQ 1551
Query: 701 FKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLA 760
E A+ DH++Q K+ E + + +R + Q T Q + + D + +
Sbjct: 1552 KDIEMAERNEDHHLQVLKESE--VLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKK-- 1607
Query: 761 QEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQE--------HF 812
+E LQ + ++ K D Q +L + + C R + +L +E +
Sbjct: 1608 EELHLLQGSMVQAK------ADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNV 1661
Query: 813 KLVVLFSQMRLANFQTD-SQESIQKILAVQEESSNLMQHILGFFQ 856
++ +Q+ L + + +E++Q +L + +++IL Q
Sbjct: 1662 QISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQ 1706
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 82.8 bits (203), Expect = 1e-15
Identities = 141/692 (20%), Positives = 301/692 (43%), Gaps = 103/692 (14%)
Query: 161 QEMETLLSEA----IRLIKSLETDRADAEEALKQ-----QRSRKNMINMKIDSWSVWKLQ 211
QE E + + +L +L+ R + +E +++ ++S+K I + +LQ
Sbjct: 194 QEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQ-------QLQ 246
Query: 212 ELPLAVQKEHEAYLSDVIEL-------QWHLEDKANQLQHFEKQKTELEEANAKIQADID 264
H + +D+++ Q LE++ + L+ ++K+K + + +Q I
Sbjct: 247 ASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIK 306
Query: 265 -YMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIK 323
Y E +++ +E+Q+ K+ + +L+ K+ EE ++ LE ++ A ++
Sbjct: 307 VYEMEQDKKVENSNKEEIQE------KETIIEELNTKIIEEEKKTLEL-KDKLTTADKLL 359
Query: 324 EEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSK 383
E+ + I Q + I+ K E+ S + + +EE ++ R K S+
Sbjct: 360 GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQK------RNHKDSQ 413
Query: 384 NELHSLSKM-------LEDLRRVYDQLTWKQKSHENQYL--EAVNDFYAAKKTWDIELSD 434
E + +M LE LR D++ +Q Q L + + K E+ +
Sbjct: 414 FETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMEN 473
Query: 435 VAKDFSAISLACTKLTEDNKKL-EIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDK 493
+ +S I++ ED KL + IN++ +K ++ +K K + E+ + K +
Sbjct: 474 ALRSYSNITV-----NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR 528
Query: 494 HLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQK 553
L+++ +E + E E K+ E + E+ + E+ + +K
Sbjct: 529 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDL-----KAEIVSASESRK 583
Query: 554 KLYSIYEVQA------LERKELIKNRAICAMSL---AELQEPLLQL----EDEAERIRS- 599
+L +E + LE E KN + M+ AEL+ QL E+E +++
Sbjct: 584 ELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKED 643
Query: 600 LDKEHSVMLNNIIDQKDL-IRRKVGKVKKKLRKKGKKTL---DALIETESK---RSAIFK 652
L+ EH + + + D + ++++ ++ ++ +K + D LI +++ + K
Sbjct: 644 LEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLK 703
Query: 653 DLEAT--KSKTMIFYAKINELNEE---LKAKEEEKKSFDQTLEILKNKFITMRFKREHAQ 707
DL+ + SK+ +INEL +E L+ +E+EK + +Q ++ L+ K
Sbjct: 704 DLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLK-----------T 752
Query: 708 TVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQ 767
+ + M+EK++ + F + + +L +KTL+D KI + ++QE + +
Sbjct: 753 ELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKI-------HTPVSQEERLIF 805
Query: 768 ITFLKEKDNYFNIYDKQLS-LDTSIRDKKQLC 798
+ +K K ++++K++ L D KQ C
Sbjct: 806 LDSIKSKSK-DSVWEKEIEILIEENEDLKQQC 836
Score = 76.6 bits (187), Expect = 9e-14
Identities = 153/795 (19%), Positives = 314/795 (39%), Gaps = 139/795 (17%)
Query: 150 EKRDEKCPEL---KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWS 206
+++ +KC EL K++++ + E I+ LE + E+AL + + +
Sbjct: 2119 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGA 2178
Query: 207 VWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYM 266
V EL L VQ + E D E ++ N + E+ + ELE N ++Q +
Sbjct: 2179 VEAKPELSLEVQLQAERDAIDRKE-----KEITNLEEQLEQFREELENKNEEVQ-QLHMQ 2232
Query: 267 NEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELE---------EALEACENARL 317
E + + QEL+ +K ME + L K ++ + + + + +
Sbjct: 2233 LEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV 2292
Query: 318 KAQQIKEEIDK-----DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEV 372
+ Q+ E++ K I D K IE I L + + S V N EE+ E++
Sbjct: 2293 EIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQL 2352
Query: 373 TEAIRET---------KSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYA 423
E I + K+S N HSLS+ + L+ D + ++ + E Q A +
Sbjct: 2353 NEVIEKLQQELANIGQKTSMNA-HSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF 2411
Query: 424 AK---KTWDIELSDVAKDF------------------SAISLACTKLTEDNKKLEIDINK 462
K K + +++ + ++ +++++A L++D +LE+ + +
Sbjct: 2412 MKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTE 2471
Query: 463 ITVKTNE------SIRKKSK-----YESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHL 511
+K+ E S + K E+ + L D L YK+ I +
Sbjct: 2472 DALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQ---IKDMQEQ 2528
Query: 512 TKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYE----------- 560
+ +T+ ++ KI L+K+ + +VAA +V Q +L ++ E
Sbjct: 2529 GQFETEMLQKKIVN-----------LQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTI 2577
Query: 561 -----------VQALERKELIKNRAICAMSLAELQEPLLQLED----EAERIRSLDKEHS 605
+ L EL + + + ++EL+ ++++ E E++ +K
Sbjct: 2578 SSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVL 2637
Query: 606 VMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIET-----ESKRSAIFKDLEA---- 656
+++ + L+ K ++K +K+ + ++ L T ++ S F +LEA
Sbjct: 2638 EKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE 2697
Query: 657 ---TKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHY 713
TK++ + K +L EEL KE S + L +++ + K + +
Sbjct: 2698 SVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETE 2757
Query: 714 MQE-KKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLK 772
+QE KK C +FE L ++ K IA + L+++ Q QI +K
Sbjct: 2758 VQESKKAC---MFEP-------LPIK------LSKSIASQTDGTLKISSSNQTPQI-LVK 2800
Query: 773 EKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQE 832
N+ + S + + + + Q ++ + + H ++ ++ +T +E
Sbjct: 2801 NAGIQINLQSECSSEEVT----EIISQFTEKIEKMQELHAAEILDMESRHISETETLKRE 2856
Query: 833 SIQKILAVQEESSNL 847
+ ++EE L
Sbjct: 2857 HYVAVQLLKEECGTL 2871
Score = 64.3 bits (155), Expect = 5e-10
Identities = 153/851 (17%), Positives = 332/851 (39%), Gaps = 146/851 (17%)
Query: 34 WSR-TNEGNAMSQSLVLYGASKENSEGFHESKMTNTEGVNKGIYFSYPCRRHSCAVVNIP 92
WS+ T EG +SQ LV G + + +E M N +
Sbjct: 1811 WSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQA------------------ 1852
Query: 93 APCVNKMISHIQDVESKIQEHLKRFETSFEEWS---RTSSTKDLKEDWSVTTPVKEVKPG 149
V K++ I + S++ EH K +T S + +T+ LK + + E
Sbjct: 1853 --AVEKLLEAISETSSQL-EHAKVTQTELMRESFRQKQEATESLKCQEELRERLHE--ES 1907
Query: 150 EKRDEKCPEL-------------KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKN 196
R++ EL K E + E +I LE + A L++ + +
Sbjct: 1908 RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQ 1967
Query: 197 MINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEAN 256
I QE + ++ EA ++ ++ L + +L K+K E++
Sbjct: 1968 QI------------QEERELLSRQKEAMKAEAGPVEQQLLQETEKLM---KEKLEVQCQA 2012
Query: 257 AKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENAR 316
K++ D+ + L + Q + ++ +K E+MDL R+ N+ LE+ LE
Sbjct: 2013 EKVRDDLQ--KQVKALEIDVEEQVSRFIELEQEKNTELMDL-RQQNQALEKQLEKMRKF- 2068
Query: 317 LKAQQIKEEIDKDIYQDE-KTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEA 375
L Q I E ++D++Q E + +E + + + + +H + V + +++EK ++ +E
Sbjct: 2069 LDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSEL 2128
Query: 376 IRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDV 435
+ + + ++ ++ +E +L ++ + E L + + F +
Sbjct: 2129 LLSKEQLQRDIQERNEEIE-------KLEFRVRELEQALLVSADTFQKVEDR-------- 2173
Query: 436 AKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHL 495
K F A+ K E+ + ++I +K K EI L + + L
Sbjct: 2174 -KHFGAVEA----------KPELSLEVQLQAERDAIDRKEK---EITNLEEQLEQFREEL 2219
Query: 496 KNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKL 555
+N +E ++ + K ++ ++ + + FK E L + A Q L
Sbjct: 2220 ENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVL 2279
Query: 556 YSIYEVQALERKELIKNRAICAMSLAELQEPLL------QLEDEAERIRSLDKEHSVMLN 609
+ + Q ++ KE+ ++ + +LQ+ L +E++ E IR L+ + +++
Sbjct: 2280 FGKF-AQIIQEKEVEIDQL--NEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMS 2336
Query: 610 -------NIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTM 662
N ++ + + + K++++L G+KT + ++ L+ ++ +
Sbjct: 2337 DQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL 2396
Query: 663 IFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTV-----------FD 711
++ NEE+ + K + + L + +++ +RE + + D
Sbjct: 2397 ALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAID 2456
Query: 712 HYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFL 771
H ++K + E + E+ K+L++ + S EEN
Sbjct: 2457 HLSKDKPELEVVLTED----------ALKSLEN--QTYFKSFEEN--------------- 2489
Query: 772 KEKDNYFNIYDKQLSLDTSIRDKK-QLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDS 830
K + N+ + L L++++ K +L Q +++ + QE + Q ++ N Q
Sbjct: 2490 -GKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDM-QEQGQFETEMLQKKIVNLQKIV 2547
Query: 831 QESIQKILAVQ 841
+E + L Q
Sbjct: 2548 EEKVAAALVSQ 2558
Score = 59.3 bits (142), Expect = 1e-08
Identities = 140/713 (19%), Positives = 298/713 (41%), Gaps = 106/713 (14%)
Query: 106 VESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKR-DEKCPELKQEME 164
VE+ +E ++ ET EE + TK ++E+ ++ +K E ++ Q+ +
Sbjct: 316 VENSNKEEIQEKETIIEELN----TKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
Query: 165 TLLSEAIRLIKSLETDRADAEEALK--------QQRSRKNM-----INMKIDSWSVWKLQ 211
+ + + L S + +R +EE + Q+R+ K+ I +++ + KL+
Sbjct: 372 EIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLE 431
Query: 212 ELPLAVQKEHEAYLSDVIELQWHL--EDKANQLQHFEKQKTELEEA-----NAKIQAD-I 263
+L + E Y +++++ L + A + + K E+E A N + D I
Sbjct: 432 QLRAELD---EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI 488
Query: 264 DYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDL--------HRKVNEELEEALEACENA 315
MN + ++ N +LQD + +K E + L R++ + +EE + E
Sbjct: 489 KLMN----VAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQI 544
Query: 316 RLKAQQIKEEIDK--DIYQDEKTIEAYKREIYQLNS----LFDHYSSSVINVNTNIEEKE 369
+ Q I E+ K + ++ T+E K EI + L + + V N +E E
Sbjct: 545 QRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLE 604
Query: 370 EEVTEAI-RETKSSKNELH------------SLSKMLEDLRRVYDQLTWKQKSHENQYLE 416
+E + R +S + EL LSK+ EDL + K K + + +
Sbjct: 605 KEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYK 664
Query: 417 AVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSK 476
D + + IE KD + I+ + E +K ++ + + K+ E + ++
Sbjct: 665 QQIDGLQNEMSQKIETMQFEKD-NLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 723
Query: 477 YESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEV-------RRK 529
+ EI+ L + + + + + + L K K +++++K A++ + +
Sbjct: 724 LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDE 783
Query: 530 FKGREEFLK---KLTQGE--VAAGMVLQKKLYSIYEVQA---LERKELIKNRAI------ 575
K E+ LK ++Q E + + K S++E + +E E +K + I
Sbjct: 784 KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI 843
Query: 576 -------------CAMSLAELQEP---LLQLEDEAERIRSLDK-EHSVMLNNIIDQKDL- 617
++ ELQE LL+++D+ E ++ + E+ L + ++ L
Sbjct: 844 EKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQ 903
Query: 618 -IRRKVGKVKKKLRKKGK----KTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELN 672
I K+K + + K +TL+ E + + + LE TK + + ++++L+
Sbjct: 904 RINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLS 963
Query: 673 EELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEK-KDCEERI 724
E+LK K E ++ ++ LK + + + + + +H E + C+ ++
Sbjct: 964 EQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQV 1016
Score = 53.9 bits (128), Expect = 6e-07
Identities = 147/751 (19%), Positives = 293/751 (39%), Gaps = 106/751 (14%)
Query: 144 KEVKPGEKRDEKCPELKQEMETLLSEA----IRLIKSLETDRADAEEALKQQ------RS 193
KE + K ++ PE+ L +A ++++ + A EE + + RS
Sbjct: 1701 KEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
Query: 194 RKNMINMKIDSWSVWKLQ---ELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKT 250
K+ + + +W+ + + V +EH + I + N + + K
Sbjct: 1761 SKSQSSASL----IWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTE 1816
Query: 251 ELEEANAKIQ------ADIDYMNEHGPL-LDSKQNQELQDLKNHYKKKMEVMDLHRKVN- 302
E E + ++ +ID NE L + S+ ++ L + ++ H KV
Sbjct: 1817 EGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLE-HAKVTQ 1875
Query: 303 -----EELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSS 357
E + EA E+ LK Q EE+ + ++++ + E E+ + + D Y+
Sbjct: 1876 TELMRESFRQKQEATES--LKCQ---EELRERLHEESRAREQLAVELSKAEGVIDGYADE 1930
Query: 358 VINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSH------- 410
I+EK + + +E + N L L + ++ + L+ ++++
Sbjct: 1931 KTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV 1990
Query: 411 ENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNES 470
E Q L+ K + V D L + K LEID+ + + +
Sbjct: 1991 EQQLLQETEKLMKEKLEVQCQAEKVRDD----------LQKQVKALEIDVEE---QVSRF 2037
Query: 471 IRKKSKYESEIKYLTIMKLKNDKHLKNIYK--EAYRIGTLFHLTKHKTDEMEDKIAEVRR 528
I + + +E+ L +K L+ + K + I +H+ D + +I ++ +
Sbjct: 2038 IELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID-----REHERDVFQQEIQKLEQ 2092
Query: 529 KFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLL 588
+ K F + + E A KE + +S +LQ +
Sbjct: 2093 QLKVVPRF------------QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQ 2140
Query: 589 QLEDEAERI--RSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESK 646
+ +E E++ R + E +++++ QK R+ G V + K L ++ +++
Sbjct: 2141 ERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAV------EAKPELSLEVQLQAE 2194
Query: 647 RSAI-FKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREH 705
R AI K+ E T + ++ + EEL+ K EE + LEI K + T + E
Sbjct: 2195 RDAIDRKEKEITNLE-----EQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQ 2249
Query: 706 AQTVFDHYMQE-KKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQ 764
+F M++ +E Q VL + +Q+ +++ D L E + Q Q
Sbjct: 2250 ENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQE-KEVEIDQLNEQVTKLQ--Q 2306
Query: 765 QLQIT----FLKEKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQ 820
QL+IT ++EK+ I D + ++ + D Q C + R + E V+ Q
Sbjct: 2307 QLKITTDNKVIEEKNEL--IRDLETQIECLMSD--QECVKRNREEEI--EQLNEVIEKLQ 2360
Query: 821 MRLANFQTDSQESIQKILAVQEESSNLMQHI 851
LAN Q++ ++ EE+ +L +
Sbjct: 2361 QELANI---GQKTSMNAHSLSEEADSLKHQL 2388
Score = 48.9 bits (115), Expect = 2e-05
Identities = 98/450 (21%), Positives = 176/450 (39%), Gaps = 74/450 (16%)
Query: 100 ISHIQDVESKIQEHLKRFETSFEEWSRT-SSTKDLKEDWSVTTPVKEVKPGEKRDEKCPE 158
+S Q ++Q L+ + E S T ++L + + +P ++ E
Sbjct: 3288 LSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKE 3347
Query: 159 LKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQ 218
L++++E S + L+ E + D+ + +QQ + ++ K ++ QE Q
Sbjct: 3348 LQKQLEEKHSRIVELLNETEKYKLDSLQT-RQQMEKDRQVHRK----TLQTEQEANTEGQ 3402
Query: 219 KEHEAYLSDVIELQWHLEDKANQ--------------LQHFEKQKTELEEANAKIQADID 264
K+ S V +LQ LE+K Q +Q F+KQ+ E EE + I
Sbjct: 3403 KKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRR--IL 3460
Query: 265 YMNEHGPLLDS-----------KQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEA-- 311
Y N + P S +Q E + +++Y K +E+ N ELE +
Sbjct: 3461 YQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQ 3520
Query: 312 CENARLKA--QQIKEEIDKDIYQDEKTI---EAYKREIYQLNSLFDHY---------SSS 357
C ++L+ Q+ E + + DE I E I QL L S+S
Sbjct: 3521 CVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTS 3580
Query: 358 VINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQY--- 414
++ + + E+T I + KN+L ++ LE+ R Y Q T + + +++
Sbjct: 3581 CGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQ-TGAGRDNSSRFSLN 3639
Query: 415 ----LEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKK------LEIDINKIT 464
+EA+ + K+ W+ E + K KL + + L D +T
Sbjct: 3640 GGANIEAI--IASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVT 3697
Query: 465 VK-------TNESIRKKSKYESEIKYLTIM 487
+K ES RK Y+ KYL ++
Sbjct: 3698 LKRIYGKYLRAESFRKALIYQK--KYLLLL 3725
Score = 45.8 bits (107), Expect = 2e-04
Identities = 64/286 (22%), Positives = 128/286 (44%), Gaps = 36/286 (12%)
Query: 103 IQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKR---DEKCPEL 159
+ +++S++ + ET+ + + K LKE + VK+ K E D E
Sbjct: 3161 VAELKSELAQTKLELETTLK-----AQHKHLKELEAFRLEVKD-KTDEVHLLNDTLASEQ 3214
Query: 160 KQEME---TLLSEAIRLIKSLETDRADAEE---ALKQQRSRKNMINMKIDSWSVWKLQEL 213
K+ E L E +L +S E D+ + E+ +L+ Q+ R +N+ ++ L E
Sbjct: 3215 KKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQL-LNES 3273
Query: 214 PLAVQKE---HEAYLSDV----IELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYM 266
++ + ++A LS+ +ELQ LE + +++ E +A++Q+ D
Sbjct: 3274 QQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSS-DGT 3332
Query: 267 NEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEI 326
+ P L S +DL +K++E + H ++ E L E E +L + Q ++++
Sbjct: 3333 GQSRPPLPS------EDLLKELQKQLE--EKHSRIVELLNET----EKYKLDSLQTRQQM 3380
Query: 327 DKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEV 372
+KD KT++ + + S V ++ +EEK ++V
Sbjct: 3381 EKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQV 3426
Score = 40.4 bits (93), Expect = 0.007
Identities = 64/338 (18%), Positives = 137/338 (40%), Gaps = 22/338 (6%)
Query: 100 ISHIQDVESKIQEHLKRF--ETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCP 157
I + +V K+Q+ L +TS S + LK V + E E++ E
Sbjct: 2349 IEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVV--IAEKLALEQQVETAN 2406
Query: 158 ELKQEMETLLSEAI----RLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQEL 213
E M+ +L E +L + L + + + E K Q +N +N+ ID S K EL
Sbjct: 2407 EEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDK-PEL 2465
Query: 214 PLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANA-------KIQADIDYM 266
+ + ++ L + + E+ + + E + +LE + + I M
Sbjct: 2466 EVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDM 2525
Query: 267 NEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEI 326
E G +++ +L+ ++K+ + + E ++E + C++ Q I E
Sbjct: 2526 QEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDN----QTISSEP 2581
Query: 327 DKDIYQDEKTI--EAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKN 384
++ Q+ + + +I L S V+ ++T++ ++E+V A + +
Sbjct: 2582 ERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEK 2641
Query: 385 ELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFY 422
+L L K+LE + + K+ + + L+ + +
Sbjct: 2642 KLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELF 2679
Score = 32.3 bits (72), Expect = 1.9
Identities = 65/350 (18%), Positives = 150/350 (42%), Gaps = 47/350 (13%)
Query: 531 KGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQL 590
K +E L+ Q + + + +Q +L S+ + +++L + + A +EL + L+L
Sbjct: 3116 KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLEL 3175
Query: 591 ED------------EAERIRSLDKEHSV-MLNNII--DQK---------DLIRRKVGK-- 624
E EA R+ DK V +LN+ + +QK + + K+G+
Sbjct: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
Query: 625 ---------VKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINE---LN 672
+K L + ++ L + E ++ + + + +S+ M++ A+++E N
Sbjct: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3295
Query: 673 EELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKD---CEERIFEEDQ 729
EL+ E +K + I + R + HAQ + + E+ + E +
Sbjct: 3296 LELQVLLESEK-----VRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQK 3350
Query: 730 RFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDT 789
+ + + L +T+K DSL+ ++ ++ Q + T E++ K L +
Sbjct: 3351 QLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQS 3410
Query: 790 SIRD-KKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKIL 838
+ D ++QL + +++++ L E +L + + + + + + ++IL
Sbjct: 3411 KVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRIL 3460
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 82.8 bits (203), Expect = 1e-15
Identities = 141/692 (20%), Positives = 301/692 (43%), Gaps = 103/692 (14%)
Query: 161 QEMETLLSEA----IRLIKSLETDRADAEEALKQ-----QRSRKNMINMKIDSWSVWKLQ 211
QE E + + +L +L+ R + +E +++ ++S+K I + +LQ
Sbjct: 194 QEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQ-------QLQ 246
Query: 212 ELPLAVQKEHEAYLSDVIEL-------QWHLEDKANQLQHFEKQKTELEEANAKIQADID 264
H + +D+++ Q LE++ + L+ ++K+K + + +Q I
Sbjct: 247 ASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIK 306
Query: 265 -YMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIK 323
Y E +++ +E+Q+ K+ + +L+ K+ EE ++ LE ++ A ++
Sbjct: 307 VYEMEQDKKVENSNKEEIQE------KETIIEELNTKIIEEEKKTLEL-KDKLTTADKLL 359
Query: 324 EEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSK 383
E+ + I Q + I+ K E+ S + + +EE ++ R K S+
Sbjct: 360 GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQK------RNHKDSQ 413
Query: 384 NELHSLSKM-------LEDLRRVYDQLTWKQKSHENQYL--EAVNDFYAAKKTWDIELSD 434
E + +M LE LR D++ +Q Q L + + K E+ +
Sbjct: 414 FETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMEN 473
Query: 435 VAKDFSAISLACTKLTEDNKKL-EIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDK 493
+ +S I++ ED KL + IN++ +K ++ +K K + E+ + K +
Sbjct: 474 ALRSYSNITV-----NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR 528
Query: 494 HLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQK 553
L+++ +E + E E K+ E + E+ + E+ + +K
Sbjct: 529 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDL-----KAEIVSASESRK 583
Query: 554 KLYSIYEVQA------LERKELIKNRAICAMSL---AELQEPLLQL----EDEAERIRS- 599
+L +E + LE E KN + M+ AEL+ QL E+E +++
Sbjct: 584 ELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKED 643
Query: 600 LDKEHSVMLNNIIDQKDL-IRRKVGKVKKKLRKKGKKTL---DALIETESK---RSAIFK 652
L+ EH + + + D + ++++ ++ ++ +K + D LI +++ + K
Sbjct: 644 LEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLK 703
Query: 653 DLEAT--KSKTMIFYAKINELNEE---LKAKEEEKKSFDQTLEILKNKFITMRFKREHAQ 707
DL+ + SK+ +INEL +E L+ +E+EK + +Q ++ L+ K
Sbjct: 704 DLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLK-----------T 752
Query: 708 TVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQ 767
+ + M+EK++ + F + + +L +KTL+D KI + ++QE + +
Sbjct: 753 ELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKI-------HTPVSQEERLIF 805
Query: 768 ITFLKEKDNYFNIYDKQLS-LDTSIRDKKQLC 798
+ +K K ++++K++ L D KQ C
Sbjct: 806 LDSIKSKSK-DSVWEKEIEILIEENEDLKQQC 836
Score = 73.9 bits (180), Expect = 6e-13
Identities = 155/795 (19%), Positives = 316/795 (39%), Gaps = 147/795 (18%)
Query: 150 EKRDEKCPEL---KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWS 206
+++ +KC EL K++++ + E I+ LE + E+AL + RK+ +
Sbjct: 2119 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVE-DRKHF-------GA 2170
Query: 207 VWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYM 266
V EL L VQ + E D E ++ N + E+ + ELE N ++Q +
Sbjct: 2171 VEAKPELSLEVQLQAERDAIDRKE-----KEITNLEEQLEQFREELENKNEEVQ-QLHMQ 2224
Query: 267 NEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELE---------EALEACENARL 317
E + + QEL+ +K ME + L K ++ + + + + +
Sbjct: 2225 LEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV 2284
Query: 318 KAQQIKEEIDK-----DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEV 372
+ Q+ E++ K I D K IE I L + + S V N EE+ E++
Sbjct: 2285 EIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQL 2344
Query: 373 TEAIRET---------KSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYA 423
E I + K+S N HSLS+ + L+ D + ++ + E Q A +
Sbjct: 2345 NEVIEKLQQELANIGQKTSMNA-HSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF 2403
Query: 424 AK---KTWDIELSDVAKDF------------------SAISLACTKLTEDNKKLEIDINK 462
K K + +++ + ++ +++++A L++D +LE+ + +
Sbjct: 2404 MKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTE 2463
Query: 463 ITVKTNE------SIRKKSK-----YESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHL 511
+K+ E S + K E+ + L D L YK+ I +
Sbjct: 2464 DALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQ---IKDMQEQ 2520
Query: 512 TKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYE----------- 560
+ +T+ ++ KI L+K+ + +VAA +V Q +L ++ E
Sbjct: 2521 GQFETEMLQKKIVN-----------LQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTI 2569
Query: 561 -----------VQALERKELIKNRAICAMSLAELQEPLLQLED----EAERIRSLDKEHS 605
+ L EL + + + ++EL+ ++++ E E++ +K
Sbjct: 2570 SSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVL 2629
Query: 606 VMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIET-----ESKRSAIFKDLEA---- 656
+++ + L+ K ++K +K+ + ++ L T ++ S F +LEA
Sbjct: 2630 EKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE 2689
Query: 657 ---TKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHY 713
TK++ + K +L EEL KE S + L +++ + K + +
Sbjct: 2690 SVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETE 2749
Query: 714 MQE-KKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLK 772
+QE KK C +FE L ++ K IA + L+++ Q QI +K
Sbjct: 2750 VQESKKAC---MFEP-------LPIK------LSKSIASQTDGTLKISSSNQTPQI-LVK 2792
Query: 773 EKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQE 832
N+ + S + + + + Q ++ + + H ++ ++ +T +E
Sbjct: 2793 NAGIQINLQSECSSEEVT----EIISQFTEKIEKMQELHAAEILDMESRHISETETLKRE 2848
Query: 833 SIQKILAVQEESSNL 847
+ ++EE L
Sbjct: 2849 HYVAVQLLKEECGTL 2863
Score = 59.3 bits (142), Expect = 1e-08
Identities = 140/713 (19%), Positives = 298/713 (41%), Gaps = 106/713 (14%)
Query: 106 VESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKR-DEKCPELKQEME 164
VE+ +E ++ ET EE + TK ++E+ ++ +K E ++ Q+ +
Sbjct: 316 VENSNKEEIQEKETIIEELN----TKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
Query: 165 TLLSEAIRLIKSLETDRADAEEALK--------QQRSRKNM-----INMKIDSWSVWKLQ 211
+ + + L S + +R +EE + Q+R+ K+ I +++ + KL+
Sbjct: 372 EIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLE 431
Query: 212 ELPLAVQKEHEAYLSDVIELQWHL--EDKANQLQHFEKQKTELEEA-----NAKIQAD-I 263
+L + E Y +++++ L + A + + K E+E A N + D I
Sbjct: 432 QLRAELD---EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI 488
Query: 264 DYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDL--------HRKVNEELEEALEACENA 315
MN + ++ N +LQD + +K E + L R++ + +EE + E
Sbjct: 489 KLMN----VAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQI 544
Query: 316 RLKAQQIKEEIDK--DIYQDEKTIEAYKREIYQLNS----LFDHYSSSVINVNTNIEEKE 369
+ Q I E+ K + ++ T+E K EI + L + + V N +E E
Sbjct: 545 QRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLE 604
Query: 370 EEVTEAI-RETKSSKNELH------------SLSKMLEDLRRVYDQLTWKQKSHENQYLE 416
+E + R +S + EL LSK+ EDL + K K + + +
Sbjct: 605 KEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYK 664
Query: 417 AVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSK 476
D + + IE KD + I+ + E +K ++ + + K+ E + ++
Sbjct: 665 QQIDGLQNEMSQKIETMQFEKD-NLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE 723
Query: 477 YESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEV-------RRK 529
+ EI+ L + + + + + + L K K +++++K A++ + +
Sbjct: 724 LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDE 783
Query: 530 FKGREEFLK---KLTQGE--VAAGMVLQKKLYSIYEVQA---LERKELIKNRAI------ 575
K E+ LK ++Q E + + K S++E + +E E +K + I
Sbjct: 784 KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI 843
Query: 576 -------------CAMSLAELQEP---LLQLEDEAERIRSLDK-EHSVMLNNIIDQKDL- 617
++ ELQE LL+++D+ E ++ + E+ L + ++ L
Sbjct: 844 EKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQ 903
Query: 618 -IRRKVGKVKKKLRKKGK----KTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELN 672
I K+K + + K +TL+ E + + + LE TK + + ++++L+
Sbjct: 904 RINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLS 963
Query: 673 EELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEK-KDCEERI 724
E+LK K E ++ ++ LK + + + + + +H E + C+ ++
Sbjct: 964 EQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQV 1016
Score = 49.7 bits (117), Expect = 1e-05
Identities = 145/751 (19%), Positives = 291/751 (38%), Gaps = 114/751 (15%)
Query: 144 KEVKPGEKRDEKCPELKQEMETLLSEA----IRLIKSLETDRADAEEALKQQ------RS 193
KE + K ++ PE+ L +A ++++ + A EE + + RS
Sbjct: 1701 KEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760
Query: 194 RKNMINMKIDSWSVWKLQ---ELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKT 250
K+ + + +W+ + + V +EH + I + N + + K
Sbjct: 1761 SKSQSSASL----IWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTE 1816
Query: 251 ELEEANAKIQ------ADIDYMNEHGPL-LDSKQNQELQDLKNHYKKKMEVMDLHRKVN- 302
E E + ++ +ID NE L + S+ ++ L + ++ H KV
Sbjct: 1817 EGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLE-HAKVTQ 1875
Query: 303 -----EELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSS 357
E + EA E+ LK Q EE+ + ++++ + E E+ + + D Y+
Sbjct: 1876 TELMRESFRQKQEATES--LKCQ---EELRERLHEESRAREQLAVELSKAEGVIDGYADE 1930
Query: 358 VINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSH------- 410
I+EK + + +E + N L L + ++ + L+ ++++
Sbjct: 1931 KTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV 1990
Query: 411 ENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNES 470
E Q L+ K + V D L + K LEID+ + + +
Sbjct: 1991 EQQLLQETEKLMKEKLEVQCQAEKVRDD----------LQKQVKALEIDVEE---QVSRF 2037
Query: 471 IRKKSKYESEIKYLTIMKLKNDKHLKNIYK--EAYRIGTLFHLTKHKTDEMEDKIAEVRR 528
I + + +E+ L +K L+ + K + I +H+ D + +I ++ +
Sbjct: 2038 IELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID-----REHERDVFQQEIQKLEQ 2092
Query: 529 KFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLL 588
+ K F + + E A KE + +S +LQ +
Sbjct: 2093 QLKVVPRF------------QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQ 2140
Query: 589 QLEDEAERI--RSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESK 646
+ +E E++ R + E ++++ + R+ G V + K L ++ +++
Sbjct: 2141 ERNEEIEKLEFRVRELEQALLVED--------RKHFGAV------EAKPELSLEVQLQAE 2186
Query: 647 RSAI-FKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREH 705
R AI K+ E T + ++ + EEL+ K EE + LEI K + T + E
Sbjct: 2187 RDAIDRKEKEITNLE-----EQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQ 2241
Query: 706 AQTVFDHYMQE-KKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQ 764
+F M++ +E Q VL + +Q+ +++ D L E + Q Q
Sbjct: 2242 ENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQE-KEVEIDQLNEQVTKLQ--Q 2298
Query: 765 QLQIT----FLKEKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQ 820
QL+IT ++EK+ I D + ++ + D Q C + R + E V+ Q
Sbjct: 2299 QLKITTDNKVIEEKNEL--IRDLETQIECLMSD--QECVKRNREEEI--EQLNEVIEKLQ 2352
Query: 821 MRLANFQTDSQESIQKILAVQEESSNLMQHI 851
LAN Q++ ++ EE+ +L +
Sbjct: 2353 QELANI---GQKTSMNAHSLSEEADSLKHQL 2380
Score = 48.9 bits (115), Expect = 2e-05
Identities = 98/450 (21%), Positives = 176/450 (39%), Gaps = 74/450 (16%)
Query: 100 ISHIQDVESKIQEHLKRFETSFEEWSRT-SSTKDLKEDWSVTTPVKEVKPGEKRDEKCPE 158
+S Q ++Q L+ + E S T ++L + + +P ++ E
Sbjct: 3280 LSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKE 3339
Query: 159 LKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQ 218
L++++E S + L+ E + D+ + +QQ + ++ K ++ QE Q
Sbjct: 3340 LQKQLEEKHSRIVELLNETEKYKLDSLQT-RQQMEKDRQVHRK----TLQTEQEANTEGQ 3394
Query: 219 KEHEAYLSDVIELQWHLEDKANQ--------------LQHFEKQKTELEEANAKIQADID 264
K+ S V +LQ LE+K Q +Q F+KQ+ E EE + I
Sbjct: 3395 KKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRR--IL 3452
Query: 265 YMNEHGPLLDS-----------KQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEA-- 311
Y N + P S +Q E + +++Y K +E+ N ELE +
Sbjct: 3453 YQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQ 3512
Query: 312 CENARLKA--QQIKEEIDKDIYQDEKTI---EAYKREIYQLNSLFDHY---------SSS 357
C ++L+ Q+ E + + DE I E I QL L S+S
Sbjct: 3513 CVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTS 3572
Query: 358 VINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQY--- 414
++ + + E+T I + KN+L ++ LE+ R Y Q T + + +++
Sbjct: 3573 CGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQ-TGAGRDNSSRFSLN 3631
Query: 415 ----LEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKK------LEIDINKIT 464
+EA+ + K+ W+ E + K KL + + L D +T
Sbjct: 3632 GGANIEAI--IASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVT 3689
Query: 465 VK-------TNESIRKKSKYESEIKYLTIM 487
+K ES RK Y+ KYL ++
Sbjct: 3690 LKRIYGKYLRAESFRKALIYQK--KYLLLL 3717
Score = 45.8 bits (107), Expect = 2e-04
Identities = 64/286 (22%), Positives = 128/286 (44%), Gaps = 36/286 (12%)
Query: 103 IQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKR---DEKCPEL 159
+ +++S++ + ET+ + + K LKE + VK+ K E D E
Sbjct: 3153 VAELKSELAQTKLELETTLK-----AQHKHLKELEAFRLEVKD-KTDEVHLLNDTLASEQ 3206
Query: 160 KQEME---TLLSEAIRLIKSLETDRADAEE---ALKQQRSRKNMINMKIDSWSVWKLQEL 213
K+ E L E +L +S E D+ + E+ +L+ Q+ R +N+ ++ L E
Sbjct: 3207 KKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQL-LNES 3265
Query: 214 PLAVQKE---HEAYLSDV----IELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYM 266
++ + ++A LS+ +ELQ LE + +++ E +A++Q+ D
Sbjct: 3266 QQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSS-DGT 3324
Query: 267 NEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEI 326
+ P L S +DL +K++E + H ++ E L E E +L + Q ++++
Sbjct: 3325 GQSRPPLPS------EDLLKELQKQLE--EKHSRIVELLNET----EKYKLDSLQTRQQM 3372
Query: 327 DKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEV 372
+KD KT++ + + S V ++ +EEK ++V
Sbjct: 3373 EKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQV 3418
Score = 40.4 bits (93), Expect = 0.007
Identities = 64/338 (18%), Positives = 137/338 (40%), Gaps = 22/338 (6%)
Query: 100 ISHIQDVESKIQEHLKRF--ETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCP 157
I + +V K+Q+ L +TS S + LK V + E E++ E
Sbjct: 2341 IEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVV--IAEKLALEQQVETAN 2398
Query: 158 ELKQEMETLLSEAI----RLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQEL 213
E M+ +L E +L + L + + + E K Q +N +N+ ID S K EL
Sbjct: 2399 EEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDK-PEL 2457
Query: 214 PLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANA-------KIQADIDYM 266
+ + ++ L + + E+ + + E + +LE + + I M
Sbjct: 2458 EVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDM 2517
Query: 267 NEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEI 326
E G +++ +L+ ++K+ + + E ++E + C++ Q I E
Sbjct: 2518 QEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDN----QTISSEP 2573
Query: 327 DKDIYQDEKTI--EAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKN 384
++ Q+ + + +I L S V+ ++T++ ++E+V A + +
Sbjct: 2574 ERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEK 2633
Query: 385 ELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFY 422
+L L K+LE + + K+ + + L+ + +
Sbjct: 2634 KLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELF 2671
Score = 32.3 bits (72), Expect = 1.9
Identities = 65/350 (18%), Positives = 150/350 (42%), Gaps = 47/350 (13%)
Query: 531 KGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQL 590
K +E L+ Q + + + +Q +L S+ + +++L + + A +EL + L+L
Sbjct: 3108 KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLEL 3167
Query: 591 ED------------EAERIRSLDKEHSV-MLNNII--DQK---------DLIRRKVGK-- 624
E EA R+ DK V +LN+ + +QK + + K+G+
Sbjct: 3168 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3227
Query: 625 ---------VKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINE---LN 672
+K L + ++ L + E ++ + + + +S+ M++ A+++E N
Sbjct: 3228 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3287
Query: 673 EELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKD---CEERIFEEDQ 729
EL+ E +K + I + R + HAQ + + E+ + E +
Sbjct: 3288 LELQVLLESEK-----VRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQK 3342
Query: 730 RFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDT 789
+ + + L +T+K DSL+ ++ ++ Q + T E++ K L +
Sbjct: 3343 QLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQS 3402
Query: 790 SIRD-KKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKIL 838
+ D ++QL + +++++ L E +L + + + + + + ++IL
Sbjct: 3403 KVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRIL 3452
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 82.4 bits (202), Expect = 2e-15
Identities = 152/710 (21%), Positives = 307/710 (43%), Gaps = 108/710 (15%)
Query: 158 ELKQEMETLLSEAIRLIKSLE---TDRADAEEALKQQRSR--KNMINMKIDSWSVW-KLQ 211
E +Q+ +L E I++ + +E T DA + L+Q K + N+K + +V K
Sbjct: 87 ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 146
Query: 212 ELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGP 271
E +QK+ E ++ +EL L+ + N + +K + E+E+ + I Y+ +
Sbjct: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
Query: 272 LLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIY 331
++ + + L+N + + + +N EE L+ LKA +EE+ + +
Sbjct: 207 ATTDEKKETVTQLQNIIEANSQ--HYQKNINSLQEELLQ------LKAIH-QEEVKELMC 257
Query: 332 QDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSK 391
Q E + + ++ EI +LN L ++ NI++K E E +R+ S+ N+ + +
Sbjct: 258 QIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICS 317
Query: 392 MLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTE 451
+L EN ++E V + K + L ++ S + T +
Sbjct: 318 IL---------------LQENTFVEQVVN--EKVKHLEDTLKELESQHSILKDEVTYMNN 360
Query: 452 DNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHL 511
KLE+D I +E ++ E +I L + K + ++ + E L L
Sbjct: 361 LKLKLEMDAQHI---KDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSE------LAGL 411
Query: 512 TKHKTDEMEDKIAEVRRKFKGREEFLKKLTQ-GEVAAGMVLQKKLYSIYEVQAL------ 564
K +E EV+ +E+ K++++ E ++KL ++E+Q L
Sbjct: 412 NKQFCYTVEQHNREVQSL---KEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCEN 468
Query: 565 ---ERKELIKN----RAICAMSLAELQEPLLQLEDEAERIRSLD----KEHSVMLNNIID 613
E++E I N R I + EL E ++ E E ++ E L
Sbjct: 469 LQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFT 528
Query: 614 QKDLIRRKVGKVK---KKLRKKGK--KTLDALIETESKRSAIFKDLEATKSKTMI--FYA 666
+KD + V +++ +KL + + L+ I+ +++ ++ L ++ TM+
Sbjct: 529 EKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYL-LSLSQRDTMLKELEG 587
Query: 667 KINELNEE-------LKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTV-FDHYMQEKK 718
KIN L EE LK EE +F + E + + + + ++ QT+ ++ +++K
Sbjct: 588 KINSLTEEKDDFINKLKNSHEEMDNFHKKCE--REERLILELGKKVEQTIQYNSELEQKV 645
Query: 719 D-----CEERIFEEDQRFRVL--LAVRQKTLQDTQKIIADSL----EENLRLAQEYQQLQ 767
+ EE + E+DQ + L L V+ K L + +++++ + EEN +L+ E +QL
Sbjct: 646 NELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLS 705
Query: 768 ---ITFLKEKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKL 814
FL +K++ + K+ + QL++++ + +E L
Sbjct: 706 RDLEVFLSQKED--------------VILKEHITQLEKKLQLMVEEQDNL 741
Score = 75.5 bits (184), Expect = 2e-13
Identities = 105/539 (19%), Positives = 223/539 (41%), Gaps = 41/539 (7%)
Query: 142 PVKEVKPGEKR----DEKCPELKQEMETLLSEAIRLIKSLETDRADAE---EALKQQRSR 194
P+ VK E++ +++C E ++++ + A++ K L++ R + + E L+ RS
Sbjct: 942 PLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSE 1001
Query: 195 KNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIE-----LQWHLEDKANQLQHFEKQK 249
K+ ++ + L ++ E ++ DV + + +ED QL++ Q
Sbjct: 1002 KDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQC 1061
Query: 250 TELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHR--KVNE---- 303
+ N + A I+ + + LL+ Q E+Q K K++E L + K+ E
Sbjct: 1062 ETINSDNEDLLARIETLQSNAKLLEV-QILEVQRAKAMVDKELEAEKLQKEQKIKEHATT 1120
Query: 304 --ELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINV 361
ELEE + + + Q+ +E++ + +D + EI L + + N
Sbjct: 1121 VNELEELQVQLQKEKKQLQKTMQELEL-VKKDAQQTTLMNMEIADYERLMKELNQKLTNK 1179
Query: 362 NTNIEEKEEEVTEAIRETKSSKNELHSLSKML---EDLRRVYDQLTWKQKSHENQYLEAV 418
N IE+ E+E+ ++ ++ + E+ SL + E+ QL K K +A
Sbjct: 1180 NNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAE 1239
Query: 419 NDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYE 478
D + + EL + + ++T + K+ + + R S Y+
Sbjct: 1240 TDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIH---EHLKTSAEQHQRTLSAYQ 1296
Query: 479 SEIKYLT--IMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEF 536
+ L K ++ E+Y++ L + K M AE + RE
Sbjct: 1297 QRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQ--AETEGAKQEREHL 1354
Query: 537 LKKLTQGEVAAGMVLQKKLYSIYEVQALERKE---LIKNRAICAMSL---AELQEPLLQL 590
+ Q ++ ++ E+Q L+ + L ++ + ++ AEL+E L +
Sbjct: 1355 EMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSI 1414
Query: 591 EDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSA 649
+ E ++S EH+ ++ + Q +++R + L+++ +KT++ L + SK A
Sbjct: 1415 QSENMMMKS---EHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEA 1470
Score = 72.0 bits (175), Expect = 2e-12
Identities = 168/756 (22%), Positives = 309/756 (40%), Gaps = 125/756 (16%)
Query: 102 HIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQ 161
H ++V+S ++H K E + T + KE ++ ++ +K E+C L+Q
Sbjct: 422 HNREVQSLKEQHQKEIS----ELNETFLSDSEKEKLTLMFEIQGLK------EQCENLQQ 471
Query: 162 E-METLLS-EAIR-LIKSLETDRADAE-------EALKQQR-SRKNMINMKIDSWSVWK- 209
E E +L+ E++R +++ L+T+ ++ E++KQQ+ S + + K+ + K
Sbjct: 472 EKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKD 531
Query: 210 -LQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQH--------FEKQKTELEEANAKIQ 260
L E +Q E+E LS EL LE+ LQ ++ T L+E KI
Sbjct: 532 ALLETVNRLQGENEKLLSQQ-ELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKIN 590
Query: 261 ADIDYMNEHGPLLDSKQNQELQDLKNHYKK-------------KMEVM-----DLHRKVN 302
+ + E +K +++ N +KK K+E +L +KVN
Sbjct: 591 S----LTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVN 646
Query: 303 E---ELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVI 359
E LEE L+ + K +++ ++ K + +D++ + A + +Y+ N+ +
Sbjct: 647 ELTGGLEETLKEKDQNDQKLEKLMVQM-KVLSEDKEVLSAEVKSLYEENNKLSSEKKQL- 704
Query: 360 NVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVN 419
++ EV + +E K + L K L+ + D L ++ + Q L
Sbjct: 705 -------SRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKT 757
Query: 420 DFYAAKKTWDIELS------DVAKDFSAISLACTKLTE---------DNKKLEIDINKIT 464
Y K E+S DV A+ + K+ E D K LE++ +I
Sbjct: 758 QLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELE-KEIK 816
Query: 465 VKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIY--KEAYRIGTLFHLTKHKTDEMEDK 522
ES+ + + +S ++ K+ K L+ I KEA + L ++ +E++
Sbjct: 817 CLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQ 876
Query: 523 -----IAEVRRKFKGREEFLKK----LTQGEVAAGMVLQKKLYSIYEVQALERKELIKNR 573
+ EV + E +K + + E ++ QK+L R ELI +
Sbjct: 877 NLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRD-------RRAELILLK 929
Query: 574 AICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKG 633
A S + +PL +++ E+I +L+KE I + I+ K KK+L
Sbjct: 930 DSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKI----NKIKLVAVKAKKELDSSR 985
Query: 634 KKTLDALIETESKR------SAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQ 687
K+T E ES R SA +DL + + +E+L ++E +F+
Sbjct: 986 KETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEH 1045
Query: 688 TLEILKNKF-------ITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLL--AVR 738
+E L + T+ E + K E +I E QR + ++ +
Sbjct: 1046 RIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEV-QRAKAMVDKELE 1104
Query: 739 QKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEK 774
+ LQ QKI +E+ E ++LQ+ KEK
Sbjct: 1105 AEKLQKEQKI-----KEHATTVNELEELQVQLQKEK 1135
Score = 71.2 bits (173), Expect = 4e-12
Identities = 135/691 (19%), Positives = 283/691 (40%), Gaps = 86/691 (12%)
Query: 162 EMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEH 221
+ +T+L E I SL ++ D LK + + K + + + L L + K+
Sbjct: 577 QRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCE-----REERLILELGKKV 631
Query: 222 EAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQEL 281
E + EL+ + + L+ K+K + ++ K+ + ++E +L +
Sbjct: 632 EQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSA------ 685
Query: 282 QDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYK 341
++K+ Y++ ++ ++++ +LE L E+ LK + I Q EK ++
Sbjct: 686 -EVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILK---------EHITQLEKKLQLMV 735
Query: 342 REIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYD 401
E LN L ++ + V T + +E+ + E K+ ++ L + E L ++ +
Sbjct: 736 EEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINE 795
Query: 402 QLTWKQKSHENQYLEA---------------------VNDFYAAKKTWDIELSDVAKDFS 440
+ + + LE + D+ K EL ++ +
Sbjct: 796 EKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKE 855
Query: 441 AISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIK--------YLTIMKLKND 492
A+ ++ N+K ++ + ++ E + SK E + + + L
Sbjct: 856 ALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQ 915
Query: 493 KHLKNIYKEAYRI-GTLFHLTKHKTD------EMEDKIAEVRRKFKGREEFLKKLTQGEV 545
K L++ E + +L K D E+E+KI + ++ K +EE + K+ V
Sbjct: 916 KELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAV 975
Query: 546 AAGMVL---QKKLYSIYE-VQAL--ERKELIKNRAICAMSLAELQEPLLQLEDEAERIRS 599
A L +K+ ++ E +++L E+ +L + + LL+ E ++E++
Sbjct: 976 KAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQL-D 1034
Query: 600 LDKEHSVMLNNIIDQKDLIRR-KVGKVKKKLRKKGKKTLDALIETESKRSAIFKD--LEA 656
++KE + + I+ DL R+ + ++ + + L A IET + + + LE
Sbjct: 1035 VEKERANNFEHRIE--DLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEV 1092
Query: 657 TKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQE 716
++K M+ EL E KE++ K T+ L+ + ++ +++ Q
Sbjct: 1093 QRAKAMVD----KELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELV 1148
Query: 717 KKDCEERI---FEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRL---AQEYQQLQITF 770
KKD ++ E R++ + QK KI + LE+ +++ QE Q +IT
Sbjct: 1149 KKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKI--EDLEQEIKIQKQKQETLQEEITS 1206
Query: 771 LKEKDNYF---NIYDKQLSLDT--SIRDKKQ 796
L+ + N KQL + T + D KQ
Sbjct: 1207 LQSSVQQYEEKNTKIKQLLVKTKKELADSKQ 1237
Score = 70.9 bits (172), Expect = 5e-12
Identities = 161/777 (20%), Positives = 324/777 (41%), Gaps = 104/777 (13%)
Query: 98 KMISHIQDVESKIQEHLKRFETSFEE-----WSRTSSTKDLKEDWSVTTPVKEVKPGEKR 152
K ++ +D K+QE +++ FEE + +T D K++ +VT ++ +
Sbjct: 171 KFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKE-TVTQLQNIIEANSQH 229
Query: 153 DEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQE 212
+K QE E L +AI + ++ E + K+ + N +N ++ V + +
Sbjct: 230 YQKNINSLQE-ELLQLKAIHQ-EEVKELMCQIEASAKEHEAEINKLN-ELKENLVKQCEA 286
Query: 213 LPLAVQKEHEAYL-----------------SDVIELQWHLEDKANQ-LQHFEKQKTELEE 254
+QK++E L S +++ +E N+ ++H E ELE
Sbjct: 287 SEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELES 346
Query: 255 ANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNE-ELEEALEACE 313
++ ++ ++ YMN L K + Q +K+ + + E DL K+NE L + + C
Sbjct: 347 QHSILKDEVTYMNN----LKLKLEMDAQHIKDEFFHERE--DLEFKINELLLAKEEQGCV 400
Query: 314 NARLKAQ------QIKEEIDKDIYQDEKTIEAYKREIYQLNSLF-DHYSSSVINVNTNIE 366
+LK++ Q +++ + + E +++EI +LN F + + I+
Sbjct: 401 IEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQ 460
Query: 367 EKEEEVTEAIRETKSSKNELHSLSKMLE----DLRRVYDQLTWKQKSHENQYLEAVNDFY 422
+E+ +E + + SL +++E +L +++ + +S + Q V++
Sbjct: 461 GLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 520
Query: 423 AAKKTWDIELSDVAKDFSAISLACTKLTEDNK---KLEIDINKITVKTNESIRKKSKYES 479
+T E + + + + KL + +LE I + K + S+ ++
Sbjct: 521 QKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDT 580
Query: 480 EIKYLT-------------IMKLKND-KHLKNIYKEAYR-------IGTLFHLTKHKTDE 518
+K L I KLKN + + N +K+ R +G T E
Sbjct: 581 MLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSE 640
Query: 519 MEDKIAEVRRKFKGREEFLKKLTQGE--VAAGMVLQKKLYSIYEVQALERKELIKNRAIC 576
+E K+ E+ G EE LK+ Q + + MV K L EV + E K L +
Sbjct: 641 LEQKVNELT---GGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKL 697
Query: 577 AMSLAELQEP----LLQLEDE--AERIRSLDKEHSVMLNNIIDQKDLI-RRKVGKVKKKL 629
+ +L L Q ED E I L+K+ +M+ + L+ +V K+ K
Sbjct: 698 SSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKT 757
Query: 630 RKKG-KKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEK-KSFDQ 687
+ G K + + + +S+ + L+A AKINE L + +EK ++
Sbjct: 758 QLYGFLKEMGSEVSEDSEEKDVVNVLQAVGES----LAKINEEKCNLAFQRDEKVLELEK 813
Query: 688 TLEILKNKFITMRFKREHAQTVFDHYMQEK----KDCEERIFEEDQRFRVLLAVR---QK 740
++ L+ + + + E +++ Y QEK K+ EE E++ LL ++ +K
Sbjct: 814 EIKCLQEESVV---QCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEK 870
Query: 741 TLQDTQKII--ADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKK 795
T + Q ++ + + + ++ + + + F+KE +N K L +RD++
Sbjct: 871 TRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENL-----KPLLEQKELRDRR 922
Score = 39.3 bits (90), Expect = 0.016
Identities = 56/290 (19%), Positives = 126/290 (43%), Gaps = 51/290 (17%)
Query: 560 EVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIR 619
+++ L +++LIK M + + + +LE E E +RS +
Sbjct: 21 KLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKP----------------VT 64
Query: 620 RKVGKVKKKLRKKGKKTLDALI----ETESKRSAIFKDLEATKSKTMIFYAKINELNEEL 675
G + K L ++ LDAL+ ETE + ++ K+ K + K+ + ++EL
Sbjct: 65 EGTGDIIKALTER----LDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKEL 120
Query: 676 KAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLL 735
E+ ++ + +E LKN+ + +R K Y ++K + ++++ EE ++ L
Sbjct: 121 ---EQSHINYVKEIENLKNELMAVRSK----------YSEDKANLQKQL-EEAMNTQLEL 166
Query: 736 AVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKK 795
+ + K +++ + EE ++ +++ QI +L Q LD + +KK
Sbjct: 167 SEQLKFQNNSEDNVKKLQEEIEKIRPGFEE-QILYL------------QKQLDATTDEKK 213
Query: 796 QLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAVQEESS 845
+ + + +H++ + Q L + QE +++++ E S+
Sbjct: 214 ETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASA 263
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 82.4 bits (202), Expect = 2e-15
Identities = 155/821 (18%), Positives = 328/821 (39%), Gaps = 120/821 (14%)
Query: 98 KMISHIQDVESKI-QEHLKRFETSFEEWSRTSSTKDLKEDWSVTTP-----VKEVKPGEK 151
KM +HIQD+E ++ +E R + E+ + + K ++E+ + +KE K E
Sbjct: 947 KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMED 1006
Query: 152 RDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQ---RSRKNMINMKIDSWSV- 207
R +C E E ++ E +D EE LK++ R K+D +
Sbjct: 1007 RIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTD 1066
Query: 208 ---------WKLQELPLAVQKEHE------------------------AYLSDVIELQWH 234
++ EL L + K+ E + + ELQ
Sbjct: 1067 LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQED 1126
Query: 235 LEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPL---LDSKQNQELQDL------- 284
E + EKQK +L E ++ +++ + L +K+ QE+ +L
Sbjct: 1127 FESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE 1186
Query: 285 -KNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEID---KDIYQDEKTIEAY 340
KNH + ++ H EEL E LE + + ++ K+ ++ K++ + K ++
Sbjct: 1187 TKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQV 1246
Query: 341 KREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVY 400
K E D + V ++ + E + E + +NEL ++S +LE+ +
Sbjct: 1247 KAESEHKRKKLD---AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKG 1303
Query: 401 DQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDI 460
+ S E+Q L+ + + + LS + + + E+ ++ ++
Sbjct: 1304 IKFAKDAASLESQ-LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNL 1362
Query: 461 NK-ITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKN-------IYKEAYRIGTLFHLT 512
K + ++ K K + ++ + ++ K LK+ + ++A L
Sbjct: 1363 EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTK 1422
Query: 513 KHKTDEMEDKIAEV---RRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKEL 569
E++D ++ R+ E+ KK Q ++ ++K S + +R E
Sbjct: 1423 NRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ------LLAEEKSISARYAEERDRAEA 1476
Query: 570 -IKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKK 628
+ + A+SLA E L+ ++E ER +K+ + +++ KD + + V ++
Sbjct: 1477 EAREKETKALSLARALEEALEAKEEFER---QNKQLRADMEDLMSSKDDVGKNVHEL--- 1530
Query: 629 LRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQT 688
+K K+ L+ +E ++ EL +EL+A E+ K +
Sbjct: 1531 --EKSKRALEQQVEE--------------------MRTQLEELEDELQATEDAKLRLEVN 1568
Query: 689 LEILKNKF-ITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQK 747
++ +K +F ++ + E + +++ ++ E + ED+R + LAV K +
Sbjct: 1569 MQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAEL--EDERKQRALAVASK---KKME 1623
Query: 748 IIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDK--KQLCQLQRRMH 805
I LE + A + + I L++ Y ++L + RD+ Q + ++++
Sbjct: 1624 IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLK 1683
Query: 806 TLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAVQEESSN 846
+L E +L Q LA+ + + + Q+ + +E +N
Sbjct: 1684 SLEAE-----ILQLQEELASSERARRHAEQERDELADEITN 1719
Score = 80.9 bits (198), Expect = 5e-15
Identities = 155/803 (19%), Positives = 326/803 (40%), Gaps = 120/803 (14%)
Query: 137 WSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKN 196
W V T VK + +++E+ +E+ + + ++ LE ++ L+++
Sbjct: 835 WRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAE 894
Query: 197 MINMKIDSWSVWKLQELPLAVQK-EHEAYLSDV------------------IELQWHLED 237
+ + + ++ + LA +K E E L D+ ++Q H++D
Sbjct: 895 QLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQD 954
Query: 238 KANQLQHFE--KQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKME-- 293
QL E +QK +LE+ A +A I M E LL+ + ++ +++ KK ME
Sbjct: 955 LEEQLDEEEGARQKLQLEKVTA--EAKIKKMEEEILLLEDQNSKFIKE-----KKLMEDR 1007
Query: 294 VMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKT---IEAYKR----EIYQ 346
+ + ++ EE EE + R K + + ++++ + ++EKT +E KR E
Sbjct: 1008 IAECSSQLAEE-EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTD 1066
Query: 347 LNSLFDHYSSSVINVNTNIEEKEEEVTEAIR----ETKSSKNELHSLSKMLEDLRRVYDQ 402
L + + + + +KEEE+ A+ ET N L + ++ + + +
Sbjct: 1067 LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQED 1126
Query: 403 LTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTK-----------LTE 451
+K+ N+ + D + EL D +A TK L E
Sbjct: 1127 FE-SEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE 1185
Query: 452 DNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKE-AYRIGTL-- 508
+ K E I + + ++ + S+ + K KN + L+ KE A + L
Sbjct: 1186 ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQ 1245
Query: 509 ------------------FHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMV 550
H + D + ++AE K + + + L + G+
Sbjct: 1246 VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIK 1305
Query: 551 LQKKLYSIYEVQALERKELIKNRAICAMSLA-----------ELQEPLLQLEDEAERIRS 599
K S+ E Q + +EL++ ++L+ LQE Q E+E E ++
Sbjct: 1306 FAKDAASL-ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE---QQEEEEEARKN 1361
Query: 600 LDKEHSVMLNNIIDQKDLIRRKVGKVK--KKLRKKGKKTLDALIETESKRSAIFKDLEAT 657
L+K+ + + + D K + +G ++ ++ +KK K +AL + +++ + LE T
Sbjct: 1362 LEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKT 1421
Query: 658 KSKTMIFYAKINELNEELKAK-------EEEKKSFDQTLEILKNKFITMRFKREHAQTVF 710
K++ ++++L +L + E+++K FDQ L + K I+ R+ E +
Sbjct: 1422 KNR---LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLL--AEEKSISARYAEERDRAEA 1476
Query: 711 D------------HYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLR 758
+ ++E + +E ++++ R + + D K + + +
Sbjct: 1477 EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA 1536
Query: 759 LAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTL-WQEHFKLVVL 817
L Q+ ++++ + +D D +L L+ +++ K Q +R + T Q K +L
Sbjct: 1537 LEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK--AQFERDLQTRDEQNEEKKRLL 1594
Query: 818 FSQMRLANFQTDSQESIQKILAV 840
Q+R + + + Q+ LAV
Sbjct: 1595 IKQVRELEAELEDERK-QRALAV 1616
Score = 77.0 bits (188), Expect = 7e-14
Identities = 147/715 (20%), Positives = 297/715 (41%), Gaps = 127/715 (17%)
Query: 108 SKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLL 167
SK+Q L T EE + K K+ S+ + +++ + E E E +Q++ L
Sbjct: 1283 SKLQNELDNVSTLLEE-AEKKGIKFAKDAASLESQLQDTQ--ELLQE---ETRQKLN--L 1334
Query: 168 SEAIRLIK----SLETDRADAEEALKQQRSRKNMINMKI---------DSWSVWKLQELP 214
S IR ++ SL+ + + EEA K + + ++ D ++ L+E
Sbjct: 1335 SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAK 1394
Query: 215 LAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLD 274
+ K+ EA L LE+KA EK K L++ + D+D+ + L+
Sbjct: 1395 KKLLKDAEA-------LSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLE 1447
Query: 275 SKQNQ------ELQDLKNHYKKKMEVMDLHRKVNE--------ELEEALEACE-----NA 315
KQ + E + + Y ++ + + + E LEEALEA E N
Sbjct: 1448 KKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNK 1507
Query: 316 RLKA-----QQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSV-------INVNT 363
+L+A K+++ K++++ EK+ A ++++ ++ + + + + +
Sbjct: 1508 QLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567
Query: 364 NIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYA 423
N++ + + E +T+ +NE +++ +R + +L ++K Q AV A
Sbjct: 1568 NMQAMKAQF-ERDLQTRDEQNE-EKKRLLIKQVRELEAELEDERK----QRALAV----A 1617
Query: 424 AKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKY 483
+KK +I+L D+ A + A ++ + +KL+ + + E+ + + ++ K
Sbjct: 1618 SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK- 1676
Query: 484 LTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQG 543
+++K LK++ E ++ +E+ R + R+E ++T
Sbjct: 1677 ------ESEKKLKSLEAEILQL----------QEELASSERARRHAEQERDELADEITNS 1720
Query: 544 EVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKE 603
+L +K + LE EL+E +E +R R +
Sbjct: 1721 ASGKSALLDEKRRLEARIAQLEE---------------ELEEEQSNMELLNDRFRKTTLQ 1765
Query: 604 HSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMI 663
LN + + +K +++L ++ K+ L E E + FK AT S
Sbjct: 1766 VDT-LNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFK---ATIS---A 1818
Query: 664 FYAKINELNEELKAKEEEK----KSFDQTLEILKNKFITMRFKREHAQTVFDHYMQE--- 716
AKI +L E+L+ + +E+ K +T + LK F+ + +R HA D Y ++
Sbjct: 1819 LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHA----DQYKEQMEK 1874
Query: 717 ----KKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQ 767
K + ++ E ++ A R+K Q+ + D+ E N L++E L+
Sbjct: 1875 ANARMKQLKRQLEEAEEEATRANASRRK----LQRELDDATEANEGLSREVSTLK 1925
Score = 67.0 bits (162), Expect = 7e-11
Identities = 111/587 (18%), Positives = 242/587 (41%), Gaps = 63/587 (10%)
Query: 104 QDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEM 163
Q+ E + +++L++ + + + K + +D ++E K +D + + E
Sbjct: 1352 QEEEEEARKNLEKQVLALQS-QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE 1410
Query: 164 ETLLSEAIRLIKS-LETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQ--KE 220
+ L + + K+ L+ + D L QR + + K + +E ++ + +E
Sbjct: 1411 KALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEE 1470
Query: 221 HEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADI-DYMNEHGPLLDSKQNQ 279
+ ++ E + A L+ + K E E N +++AD+ D M+ + K
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDV--GKNVH 1528
Query: 280 ELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKA----QQIKEEIDKDIYQDEK 335
EL+ K ++++E M R EELE+ L+A E+A+L+ Q +K + ++D+ ++
Sbjct: 1529 ELEKSKRALEQQVEEM---RTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDE 1585
Query: 336 TIEAYKR----EIYQLNS-LFDHYSSSVINV-------------NTNIEEKEEEVTEAIR 377
E KR ++ +L + L D + V IE + E I+
Sbjct: 1586 QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIK 1645
Query: 378 ETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHEN----------QYLEAVNDFYAAKKT 427
+ + + ++ + LE+ R D++ + K E Q E + A++
Sbjct: 1646 QLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRH 1705
Query: 428 WDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIM 487
+ E ++A + + + + L ++ ++LE I ++ + E + T+
Sbjct: 1706 AEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ 1765
Query: 488 KLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAE----VRRKFKGR---------- 533
+ L A + + + E++ K+ E V+ KFK
Sbjct: 1766 VDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQ 1825
Query: 534 -EEFLKKLTQGEVAAGMVL---QKKLYSIYEVQALERKELIKNRAICAMSLA---ELQEP 586
EE L++ + AA ++ +KKL I+ ER+ + + + A +L+
Sbjct: 1826 LEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQ 1885
Query: 587 LLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKG 633
L + E+EA R + ++ L++ + + + R+V +K +LR+ G
Sbjct: 1886 LEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGG 1932
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 82.4 bits (202), Expect = 2e-15
Identities = 150/748 (20%), Positives = 312/748 (41%), Gaps = 126/748 (16%)
Query: 150 EKRDEKCPELKQEMETLLSEAIRLIKSLETDR---ADAEEALKQQRSRKNMINMKIDSWS 206
EK + + ELK + +L E LI L+ ++ A+ EE + K + ++ S
Sbjct: 876 EKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELS 935
Query: 207 --VWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADID 264
V + +E+ + + EL+ ++D L EK+K E + +++
Sbjct: 936 ERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVE 995
Query: 265 YMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKE 324
++NE SK N+ + ++ +++ ++ DLH + EE L + A LK +Q +
Sbjct: 996 FLNED----ISKLNRAAKVVQEAHQQTLD--DLHME-----EEKLSSLSKANLKLEQQVD 1044
Query: 325 EIDKDIYQDEKTIEAYKREIYQL-------NSLFDHYSSSVINVNTNIEEKEEEVTEAIR 377
E++ + Q+ K +RE+++L ++ SS ++ + +KE E+++
Sbjct: 1045 ELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNS 1104
Query: 378 ETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDI-ELSDVA 436
+ ++ K + L K +++L+ L K+K + A + A T D+ +L++
Sbjct: 1105 KVENEKGLVAQLQKTVKELQTQIKDL--KEKLEAERTTRAKMERERADLTQDLADLNERL 1162
Query: 437 KDFSAISLACTKLTEDN----KKLEIDINKITV---KTNESIRKK-----SKYESEIKYL 484
++ SLA ++T+ +KL D+ + T+ T+ S++K+ ++ E +++ L
Sbjct: 1163 EEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENL 1222
Query: 485 TIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTD---EMEDKIAEVRRKFKGREEFLKKLT 541
+K K L K K+D E++D + V +++T
Sbjct: 1223 QQVKQK--------------------LEKDKSDLQLEVDDLLTRV-----------EQMT 1251
Query: 542 QGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLD 601
+ + A +KL ++YE + E + A LA + L + E +R L+
Sbjct: 1252 RAKANA-----EKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKL--WSESGEFLRRLE 1304
Query: 602 KEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKT 661
E ++N + +K R++ ++ +L K+ K +SA+ L+ +
Sbjct: 1305 -EKEALINQLSREKSNFTRQIEDLRGQLEKETK-----------SQSALAHALQKAQRDC 1352
Query: 662 MIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCE 721
+ L E+ + ++E K +TL + + + R K E ++ +Q +D E
Sbjct: 1353 DL-------LREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYE------NNVIQRTEDLE 1399
Query: 722 ERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQI-------TFLKEK 774
+ E LA+R LQ+ + + + N L + QLQ+ K +
Sbjct: 1400 DAKKE--------LAIR---LQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVR 1448
Query: 775 DNYFNIYDKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESI 834
+ KQL ++ D KQ + + + Q+ + + L + +ESI
Sbjct: 1449 SAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQAL----STELLKLKNTYEESI 1504
Query: 835 QKILAVQEESSNLMQHILGFFQTLTDGT 862
++ E+ NL + I + +GT
Sbjct: 1505 VGQETLRRENKNLQEEISNLTNQVREGT 1532
Score = 70.5 bits (171), Expect = 6e-12
Identities = 84/497 (16%), Positives = 223/497 (44%), Gaps = 58/497 (11%)
Query: 160 KQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMIN-----MKIDSWSVWKLQELP 214
++E++ L +E ++L + E E ++ ++ + I+ ++ + ++ +++++
Sbjct: 1483 QKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVK 1542
Query: 215 LAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLD 274
+++E + E + LE +++ HF+ EL EA A+ L+
Sbjct: 1543 KLIEEEKTEVQVTLEETEGALERNESKILHFQ---LELLEAKAE--------------LE 1585
Query: 275 SKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDE 334
K +++ ++++N +K+ +D L+ +L++ +R++ ++K+++++D+ + E
Sbjct: 1586 RKLSEKDEEIENFRRKQQCTID-------SLQSSLDSEAKSRIEVTRLKKKMEEDLNEME 1638
Query: 335 KTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLE 394
+ R++ + + ++ +++ + ++ + ++ L LE
Sbjct: 1639 LQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELE 1698
Query: 395 DLRRVYDQLTWKQKSHENQYLEA---VNDFY-------AAKKTWDIELSDVAKDFSAISL 444
DLR + +Q ++ E + LEA +N FY + KK + +++ + K+ +
Sbjct: 1699 DLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQ 1758
Query: 445 ACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYK---E 501
C E KK I+ +E ++KK + I +L + ++ + ++ K E
Sbjct: 1759 ECQNAEEKAKKAAIE----AANLSEELKKK---QDTIAHLERTRENMEQTITDLQKRLAE 1811
Query: 502 AYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEV 561
A ++ + ++ + ++E ++ E+ + +G + +G +++ Y E
Sbjct: 1812 AEQMALMG--SRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEE- 1868
Query: 562 QALERKELIKNRAICAMSLAELQEPLLQL---EDEAERIRSLDKEHSVMLNNIIDQKDLI 618
++K L + + ++Q Q+ E +A + S K+ LN + ++ ++
Sbjct: 1869 ---DKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVA 1925
Query: 619 RRKVGKVKKKLRKKGKK 635
+V K+K K R+ GKK
Sbjct: 1926 ESQVNKLKIKAREFGKK 1942
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 82.0 bits (201), Expect = 2e-15
Identities = 146/646 (22%), Positives = 275/646 (42%), Gaps = 103/646 (15%)
Query: 230 ELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQ---------- 279
+L+ LE +L ++KT L NA ++ + + LL SK ++
Sbjct: 21 DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRIL 80
Query: 280 --ELQDLKNHYKKKMEVMDLHRKVNE-ELEEALEACENARLKAQQI--------KEEIDK 328
EL L+N + KM M ++ E +L+ + E ++ K Q+ KE+ID+
Sbjct: 81 SLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDE 140
Query: 329 DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHS 388
+ EK +E Y EI + + Y + + N++EK +E+ +S + +
Sbjct: 141 KS-ETEKLLE-YIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSL---KQSLEENIVI 195
Query: 389 LSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAA----KKTWDIELSDVAKDFSAISL 444
LSK +EDL L +++ H N+ E + A K+ + +E + K L
Sbjct: 196 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREK-LQQKEL 254
Query: 445 ACTKLTEDNKKLEIDIN-KITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAY 503
L + K+L ++ K+ E +++K+ +E E+K T+ +L DK L+ ++A
Sbjct: 255 QIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQ-TLDEL--DK-LQQKEEQAE 310
Query: 504 RIGTLFHLTKHKTDEMEDKIAEVR---RKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYE 560
R L K +E + + E++ K KG+E L+K + A ++LQ+K S+
Sbjct: 311 R------LVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM-- 362
Query: 561 VQALE--RKELIKNRAICAMSLAELQEPLLQLEDEAERI--RSLDKEHSVMLNNIIDQKD 616
VQ+LE + +A+ A + +L+ L+++A + + D +H ++ +Q +
Sbjct: 363 VQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ-E 421
Query: 617 LIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELK 676
+R + +T AL ETE K T+ F KI +L +LK
Sbjct: 422 YVRMLLDL----------QTKSALKETEIKEI------------TVSFLQKITDLQNQLK 459
Query: 677 AKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLA 736
+EE+ F + LE + + EK++ + EE ++R+L
Sbjct: 460 QQEED---FRKQLEDEEGR------------------KAEKENTTAELTEEINKWRLLYE 498
Query: 737 VRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDK-K 795
+ Q + E L E+ Q K +D+Y + Q +++ K K
Sbjct: 499 ELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ-----NLKQKIK 553
Query: 796 QLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAVQ 841
+ +L+ L E KL ++ + + +T QE + K+L ++
Sbjct: 554 HVVKLKDENSQLKSEVSKLRCQLAKKKQS--ETKLQEELNKVLGIK 597
Score = 55.8 bits (133), Expect = 2e-07
Identities = 107/624 (17%), Positives = 256/624 (41%), Gaps = 105/624 (16%)
Query: 103 IQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSV----TTPVKEVKPGEKRDEK--- 155
IQD+E+++++ R + E + S+ E + T + + K E ++K
Sbjct: 19 IQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLR 78
Query: 156 -----CPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSR------------KNMI 198
+L+ + ET + + + +E + +L++ + + K I
Sbjct: 79 ILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKI 138
Query: 199 NMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAK 258
+ K ++ + + E + E Y D+ +L+ +L++K +++ K LEE
Sbjct: 139 DEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSL---KQSLEENIVI 195
Query: 259 IQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLK 318
+ ++ +N LL+ K+K + ++ +R+ NE L ++ + +
Sbjct: 196 LSKQVEDLNVKCQLLE--------------KEKEDHVNRNREHNENLNAEMQNLKQKFIL 241
Query: 319 AQQIKEEIDK------DIYQDEKTIE--------AYKREIYQLNSLFDHYSSSVINVNTN 364
QQ +E++ + + Q EK + +++ E+ + +LF+ ++
Sbjct: 242 EQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 301
Query: 365 IEEKEEEVTEAIR----ETKSSKNELHSLSKM-------LEDLRRVYDQLTWKQKSHENQ 413
+++KEE+ ++ E KS EL L + LE + Q T + +
Sbjct: 302 LQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDS 361
Query: 414 YLEAVND----FYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNE 469
++++ D F + K E+ D+ + S++ K ++ + ++ I E
Sbjct: 362 MVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQE 421
Query: 470 SIR-------KKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDK 522
+R K + E+EIK +T+ L+ L+N K+ + ++ +
Sbjct: 422 YVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQ-------------QEEDFRKQ 468
Query: 523 IAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYS---IYEVQ----ALERKELIKNRAI 575
+ + + +E +LT+ E+ +L ++LY+ +++Q +E++ L+
Sbjct: 469 LEDEEGRKAEKENTTAELTE-EINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGA 527
Query: 576 CAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKK 635
L ++++ +L + + +H V L D+ ++ +V K++ +L K KK
Sbjct: 528 AQEQLNKIRDSYAKLLGHQNLKQKI--KHVVKLK---DENSQLKSEVSKLRCQLAK--KK 580
Query: 636 TLDALIETESKRSAIFKDLEATKS 659
+ ++ E + K + +K+
Sbjct: 581 QSETKLQEELNKVLGIKHFDPSKA 604
Score = 43.5 bits (101), Expect = 8e-04
Identities = 59/315 (18%), Positives = 126/315 (40%), Gaps = 41/315 (13%)
Query: 546 AAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHS 605
A L+K+L + L + + +N + + L+ L+ + E + + K+
Sbjct: 45 ANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEG 104
Query: 606 VMLNNIIDQKDL--IRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMI 663
+ + + Q+ L + K+ +++ KL K+ +D ETE K +++ +
Sbjct: 105 MEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETE-KLLEYIEEISCASDQVEK 163
Query: 664 FYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEER 723
+ I +L E LK K +E S Q+LE + + + E +EK+D R
Sbjct: 164 YKLDIAQLEENLKEKNDEILSLKQSLE---ENIVILSKQVEDLNVKCQLLEKEKEDHVNR 220
Query: 724 IFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDK 783
+ E N L E Q L+ F+ E+ + K
Sbjct: 221 ----------------------------NREHNENLNAEMQNLKQKFILEQQEREKLQQK 252
Query: 784 QLSLDTSIRDKKQL-CQLQRRMHTLWQEHFKLVVLFSQM------RLANFQTDSQESIQK 836
+L +D+ ++ +K+L L +++ + +E K LF + L Q +++ +
Sbjct: 253 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 312
Query: 837 ILAVQEESSNLMQHI 851
+ ++EE+ + + +
Sbjct: 313 VKQLEEEAKSRAEEL 327
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 81.6 bits (200), Expect = 3e-15
Identities = 122/648 (18%), Positives = 260/648 (40%), Gaps = 59/648 (9%)
Query: 161 QEMETLLSEAIRL-------IKSLETDRADAEEALKQQRSRKNMINMKIDSWSVW----- 208
Q+ + LL E R ++ LE +R ++ L ++ K + I + ++
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377
Query: 209 -KLQELPLAVQKEHEA---YLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADID 264
KLQ+ V+ E + ++ L E+KA EK K L++ + D+D
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437
Query: 265 YMNEHGPLLDSKQ---NQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQ 321
+ L+ KQ +Q L + KN K + D E E + A +A +
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497
Query: 322 IKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKS 381
KEE+ E+T + K E+ L S D +V + + E ++ E + +
Sbjct: 1498 AKEEL-------ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550
Query: 382 SKNELHSLS----KMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAK 437
++EL + ++ +++ + Q ++ + Q E ++ EL D K
Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610
Query: 438 DFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKN 497
+ + A KL D K LE+ + E+I++ K ++++K + L++
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF-------QRELED 1663
Query: 498 IYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYS 557
I + K +E + +++ E K Q ++ + ++ S
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK---QADLEKEELAEELASS 1720
Query: 558 IYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDL 617
+ AL+ E + A A EL+E +E ++R+R ++ + N + ++
Sbjct: 1721 LSGRNALQ-DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1779
Query: 618 IRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELKA 677
++ +++L ++ K+ L E E + FK A AKI +L E+++
Sbjct: 1780 AQKNES-ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE------AKIAQLEEQVEQ 1832
Query: 678 KEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEK-------KDCEERIFEEDQR 730
+ EK++ ++L+ K + + E + + + Y ++ K + ++ E ++
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
Query: 731 FRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYF 778
+ + A R+K Q+ + ++ E N + +E L+ + + F
Sbjct: 1893 SQRINANRRK----LQRELDEATESNEAMGREVNALKSKLRRGNETSF 1936
Score = 80.5 bits (197), Expect = 6e-15
Identities = 155/737 (21%), Positives = 314/737 (42%), Gaps = 113/737 (15%)
Query: 98 KMISHIQDVESKIQEH-LKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKC 156
KM + D+E +++E R + E+ + + K L+++ V D++
Sbjct: 947 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM------------DDQN 994
Query: 157 PELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLA 216
+L +E + LL E I L T+ A+ EE K KN I EL +
Sbjct: 995 NKLSKERK-LLEERI---SDLTTNLAEEEEKAKNLTKLKNKHESMIS--------ELEVR 1042
Query: 217 VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSK 276
++KE ++ ++ +L+ LE A+ F +Q +L+ A+++ + E ++
Sbjct: 1043 LKKEEKSR-QELEKLKRKLEGDASD---FHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098
Query: 277 QNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKT 336
+ E+ KN+ KK+ ++ H +L+E L++ AR KA++ K ++ +++
Sbjct: 1099 LDDEIAQ-KNNALKKIRELEGHIS---DLQEDLDSERAARNKAEKQKRDLGEEL------ 1148
Query: 337 IEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDL 396
EA K E L D S+ + +E+EVT K+ E S ++++
Sbjct: 1149 -EALKTE------LEDTLDSTATQQELRAK-REQEVTVL---KKALDEETRSHEAQVQEM 1197
Query: 397 RRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKL 456
R+ + Q + Q+ A + K+T + E +D+A + + A ++ KKL
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 457 EIDINKITVKTNESIR-------KKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLF 509
E + ++ K ++ R K K ++E++ +T M + + + K+ + +
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 510 HLTKHKTDEMEDKIAEVRRKFKGREE---FLKKLTQGEVAAGMVLQKKLYSIYEVQALER 566
T+ E + V K + EE L+ E+ A L++ + S +Q +
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI-STLNIQLSDS 1376
Query: 567 KELIKNRAICAMSL--------AELQEPLLQLEDEAERIRSLDKEHSVM---LNNIIDQK 615
K+ +++ A +L E++ Q E++A L+K + + L++++
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1436
Query: 616 DLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKD------LEATKSKTMIFYAKIN 669
D R+ V ++KK RK D L+ E S+ + D EA + +T +
Sbjct: 1437 DNQRQLVSNLEKKQRK-----FDQLLAEEKNISSKYADERDRAEAEAREKETKAL-SLAR 1490
Query: 670 ELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQ 729
L E L+AKEE ++T ++LK + + + K D + + E ++
Sbjct: 1491 ALEEALEAKEE----LERTNKMLKAE--------------MEDLVSSKDDVGKNVHELEK 1532
Query: 730 RFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQ-QLQITFLKEKDNYFNIYDKQLSLD 788
R L +T + K + LE+ L+ ++ + +L++ K +++ L
Sbjct: 1533 SKRAL-----ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ----FERDLQAR 1583
Query: 789 TSIRDKKQLCQLQRRMH 805
++K+ QLQR++H
Sbjct: 1584 DEQNEEKRR-QLQRQLH 1599
Score = 73.2 bits (178), Expect = 1e-12
Identities = 157/815 (19%), Positives = 330/815 (40%), Gaps = 119/815 (14%)
Query: 120 SFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLET 179
+++ W + K L + VT +E++ E +K E +Q+ E L E ++ +
Sbjct: 831 NWQWWRLFTKVKPLLQ---VTRQEEEMQAKEDELQKTKERQQKAENELKE----LEQKHS 883
Query: 180 DRADAEEALKQQRSRKNMINMKIDSWSVW---KLQELPLAVQKEHEAYLSDVIE----LQ 232
+ + L++Q + + + + V K QEL + E EA L + + LQ
Sbjct: 884 QLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQ 942
Query: 233 WHLEDKANQLQHFEKQKTELEEANAKIQ-------ADIDYMNEHGPLLDSKQN------- 278
+ A Q+ E+Q E E A K+Q A I + + ++D + N
Sbjct: 943 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 279 ---QELQDLKNHYKKKME-------VMDLHRKVNEELEEALEACENARLKAQQIKEEIDK 328
+ + DL + ++ E + + H + ELE L+ E +R + +++K +++
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1062
Query: 329 DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHS 388
D + I + +I +L + ++++ + A+++ + + +
Sbjct: 1063 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 389 LSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDV---AKDFSAISLA 445
L + L+ R ++ KQK + LEA+ + T D + AK +++
Sbjct: 1123 LQEDLDSERAARNKAE-KQKRDLGEELEALKT--ELEDTLDSTATQQELRAKREQEVTVL 1179
Query: 446 CTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKN----DKHLKNIYKE 501
L E+ + E + ++ K +++ + ++ + K KN +K ++ E
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 502 AYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLT------QGEV--AAGMV--- 550
+G +HK ++E ++ E++ K E +L Q EV GM+
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299
Query: 551 ------LQKKLYSIYEVQALERKELI----KNRAICAMSLAELQEPLL----QLEDEAER 596
L K + S+ Q + +EL+ + + + L +L+E QL++E E
Sbjct: 1300 EGKAIKLAKDVASL-SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358
Query: 597 IRSLDKEHSVMLNNIIDQKDLIRRKVGKVK--KKLRKKGKKTLDALIETESKRSAIFKDL 654
++L++ S + + D K ++ V+ ++ +K+ +K ++ L + +++A + L
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1418
Query: 655 EATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYM 714
E TK N L +EL ++ D +++ N E Q FD +
Sbjct: 1419 EKTK----------NRLQQEL---DDLVVDLDNQRQLVSN--------LEKKQRKFDQLL 1457
Query: 715 QEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEK 774
E+K+ + D+R R R+K + +A +LEE L +E ++ E
Sbjct: 1458 AEEKNISSKY--ADERDRAEAEAREKETKALS--LARALEEALEAKEELERTNKMLKAEM 1513
Query: 775 D-----------NYFNIYDKQLSLDTSIRD-KKQLCQLQRRMHTLWQEHFKLVVLFSQMR 822
+ N + + +L+T + + K QL +L+ + +L V ++
Sbjct: 1514 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1573
Query: 823 LANFQTDSQESIQKILAVQEESSNLMQHILGFFQT 857
F+ D Q ++ EE +Q L ++T
Sbjct: 1574 -GQFERDLQARDEQ----NEEKRRQLQRQLHEYET 1603
Score = 70.9 bits (172), Expect = 5e-12
Identities = 123/591 (20%), Positives = 258/591 (43%), Gaps = 77/591 (13%)
Query: 105 DVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPE-LKQEM 163
D E + +++L+R ++ + S +K +D++ T V+ ++ G+KR +K E L Q+
Sbjct: 1353 DEEMEAKQNLERHISTLN--IQLSDSKKKLQDFAST--VEALEEGKKRFQKEIENLTQQY 1408
Query: 164 ETLLSEAIRLIKS---LETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQ-- 218
E + +L K+ L+ + D L QR + + K + +E ++ +
Sbjct: 1409 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468
Query: 219 KEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQN 278
E + ++ E + A L+ + K ELE N ++A+++ L+ SK +
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME------DLVSSKDD 1522
Query: 279 -----QELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKA----QQIKEEIDKD 329
EL+ K + +ME M EELE+ L+A E+A+L+ Q +K + ++D
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQL---EELEDELQATEDAKLRLEVNMQALKGQFERD 1579
Query: 330 IY----QDEKTIEAYKREIYQLNS-LFDHYSSSVI------NVNTNIEEKEEEVT----- 373
+ Q+E+ +R++++ + L D + + ++++ E +
Sbjct: 1580 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639
Query: 374 --EAIRETKSSKNELHSLSKMLEDLRRVYDQL-------TWKQKSHENQYLEAVNDFYAA 424
EAI++ + + ++ + LED R D++ K KS E ++ D AA
Sbjct: 1640 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699
Query: 425 ---KKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEI 481
+K D+E ++A++ ++ L ++ ++LE I ++ + E +
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759
Query: 482 KYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAE----VRRKFKGR---- 533
+ T + L A + + + + E+ K+ E V+ KFK
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819
Query: 534 -------EEFLKKLTQGEVAAGMVLQKKLYSIYEVQAL---ERK--ELIKNRAICAMS-L 580
EE +++ + + AA L++K + E+ ERK E K +A + +
Sbjct: 1820 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1879
Query: 581 AELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRK 631
+L+ L + E+E++RI + ++ L+ + + + R+V +K KLR+
Sbjct: 1880 KQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930
Score = 54.7 bits (130), Expect = 4e-07
Identities = 98/492 (19%), Positives = 206/492 (41%), Gaps = 67/492 (13%)
Query: 97 NKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKC 156
+++++ +++ SK + R E +R TK L S+ ++E ++ E+
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAE----AREKETKAL----SLARALEEALEAKEELERT 1505
Query: 157 PE-LKQEMETLLS---EAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQE 212
+ LK EME L+S + + + LE + E +++ +++ + ++ + KL+
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR- 1564
Query: 213 LPLAVQKEHEAYLSDVIELQWHLEDKANQLQH-FEKQKTELEE----------ANAKIQA 261
L + +Q + D+ E+K QLQ + +TELE+ A K++
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624
Query: 262 DIDYMNEH------GPLLDSKQNQELQDLKNHYKKKMEVMDLHR-------KVNE----- 303
D+ + G KQ ++LQ +++++E R K NE
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684
Query: 304 ------ELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSS 357
+L+E L A E AR +A KEE+ +++ A + E +L +
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 358 VINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEA 417
+ N+E + V +A ++ + NEL + ++ T ++ Q LE
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELAT------------ERSTAQKNESARQQLER 1792
Query: 418 VNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKY 477
N K ++E + +K S I+ K+ + +++E + + T +S+++K K
Sbjct: 1793 QNK-ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT-KSLKQKDKK 1850
Query: 478 ESEIKYLTIMKLKNDKHLKNIYKEAYRIGTL-FHLTKHKTDEMEDKIAEVRRKFKGREEF 536
EI ++++++++ + YKE G K + +E E++ + + +
Sbjct: 1851 LKEI----LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1906
Query: 537 LKKLTQGEVAAG 548
L + T+ A G
Sbjct: 1907 LDEATESNEAMG 1918
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 81.6 bits (200), Expect = 3e-15
Identities = 122/648 (18%), Positives = 260/648 (40%), Gaps = 59/648 (9%)
Query: 161 QEMETLLSEAIRL-------IKSLETDRADAEEALKQQRSRKNMINMKIDSWSVW----- 208
Q+ + LL E R ++ LE +R ++ L ++ K + I + ++
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 209 -KLQELPLAVQKEHEA---YLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADID 264
KLQ+ V+ E + ++ L E+KA EK K L++ + D+D
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444
Query: 265 YMNEHGPLLDSKQ---NQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQ 321
+ L+ KQ +Q L + KN K + D E E + A +A +
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504
Query: 322 IKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKS 381
KEE+ E+T + K E+ L S D +V + + E ++ E + +
Sbjct: 1505 AKEEL-------ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557
Query: 382 SKNELHSLS----KMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAK 437
++EL + ++ +++ + Q ++ + Q E ++ EL D K
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617
Query: 438 DFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKN 497
+ + A KL D K LE+ + E+I++ K ++++K + L++
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF-------QRELED 1670
Query: 498 IYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYS 557
I + K +E + +++ E K Q ++ + ++ S
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK---QADLEKEELAEELASS 1727
Query: 558 IYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDL 617
+ AL+ E + A A EL+E +E ++R+R ++ + N + ++
Sbjct: 1728 LSGRNALQ-DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1786
Query: 618 IRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELKA 677
++ +++L ++ K+ L E E + FK A AKI +L E+++
Sbjct: 1787 AQKNES-ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE------AKIAQLEEQVEQ 1839
Query: 678 KEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEK-------KDCEERIFEEDQR 730
+ EK++ ++L+ K + + E + + + Y ++ K + ++ E ++
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
Query: 731 FRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYF 778
+ + A R+K Q+ + ++ E N + +E L+ + + F
Sbjct: 1900 SQRINANRRK----LQRELDEATESNEAMGREVNALKSKLRRGNETSF 1943
Score = 80.5 bits (197), Expect = 6e-15
Identities = 155/737 (21%), Positives = 314/737 (42%), Gaps = 113/737 (15%)
Query: 98 KMISHIQDVESKIQEH-LKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKC 156
KM + D+E +++E R + E+ + + K L+++ V D++
Sbjct: 954 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM------------DDQN 1001
Query: 157 PELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLA 216
+L +E + LL E I L T+ A+ EE K KN I EL +
Sbjct: 1002 NKLSKERK-LLEERI---SDLTTNLAEEEEKAKNLTKLKNKHESMIS--------ELEVR 1049
Query: 217 VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSK 276
++KE ++ ++ +L+ LE A+ F +Q +L+ A+++ + E ++
Sbjct: 1050 LKKEEKSR-QELEKLKRKLEGDASD---FHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105
Query: 277 QNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKT 336
+ E+ KN+ KK+ ++ H +L+E L++ AR KA++ K ++ +++
Sbjct: 1106 LDDEIAQ-KNNALKKIRELEGHIS---DLQEDLDSERAARNKAEKQKRDLGEEL------ 1155
Query: 337 IEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDL 396
EA K E L D S+ + +E+EVT K+ E S ++++
Sbjct: 1156 -EALKTE------LEDTLDSTATQQELRAK-REQEVTVL---KKALDEETRSHEAQVQEM 1204
Query: 397 RRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKL 456
R+ + Q + Q+ A + K+T + E +D+A + + A ++ KKL
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 457 EIDINKITVKTNESIR-------KKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLF 509
E + ++ K ++ R K K ++E++ +T M + + + K+ + +
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 510 HLTKHKTDEMEDKIAEVRRKFKGREE---FLKKLTQGEVAAGMVLQKKLYSIYEVQALER 566
T+ E + V K + EE L+ E+ A L++ + S +Q +
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI-STLNIQLSDS 1383
Query: 567 KELIKNRAICAMSL--------AELQEPLLQLEDEAERIRSLDKEHSVM---LNNIIDQK 615
K+ +++ A +L E++ Q E++A L+K + + L++++
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1443
Query: 616 DLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKD------LEATKSKTMIFYAKIN 669
D R+ V ++KK RK D L+ E S+ + D EA + +T +
Sbjct: 1444 DNQRQLVSNLEKKQRK-----FDQLLAEEKNISSKYADERDRAEAEAREKETKAL-SLAR 1497
Query: 670 ELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQ 729
L E L+AKEE ++T ++LK + + + K D + + E ++
Sbjct: 1498 ALEEALEAKEE----LERTNKMLKAE--------------MEDLVSSKDDVGKNVHELEK 1539
Query: 730 RFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQ-QLQITFLKEKDNYFNIYDKQLSLD 788
R L +T + K + LE+ L+ ++ + +L++ K +++ L
Sbjct: 1540 SKRAL-----ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ----FERDLQAR 1590
Query: 789 TSIRDKKQLCQLQRRMH 805
++K+ QLQR++H
Sbjct: 1591 DEQNEEKRR-QLQRQLH 1606
Score = 73.2 bits (178), Expect = 1e-12
Identities = 157/815 (19%), Positives = 330/815 (40%), Gaps = 119/815 (14%)
Query: 120 SFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLET 179
+++ W + K L + VT +E++ E +K E +Q+ E L E ++ +
Sbjct: 838 NWQWWRLFTKVKPLLQ---VTRQEEEMQAKEDELQKTKERQQKAENELKE----LEQKHS 890
Query: 180 DRADAEEALKQQRSRKNMINMKIDSWSVW---KLQELPLAVQKEHEAYLSDVIE----LQ 232
+ + L++Q + + + + V K QEL + E EA L + + LQ
Sbjct: 891 QLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQ 949
Query: 233 WHLEDKANQLQHFEKQKTELEEANAKIQ-------ADIDYMNEHGPLLDSKQN------- 278
+ A Q+ E+Q E E A K+Q A I + + ++D + N
Sbjct: 950 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 279 ---QELQDLKNHYKKKME-------VMDLHRKVNEELEEALEACENARLKAQQIKEEIDK 328
+ + DL + ++ E + + H + ELE L+ E +R + +++K +++
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1069
Query: 329 DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHS 388
D + I + +I +L + ++++ + A+++ + + +
Sbjct: 1070 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 389 LSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDV---AKDFSAISLA 445
L + L+ R ++ KQK + LEA+ + T D + AK +++
Sbjct: 1130 LQEDLDSERAARNKAE-KQKRDLGEELEALKT--ELEDTLDSTATQQELRAKREQEVTVL 1186
Query: 446 CTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKN----DKHLKNIYKE 501
L E+ + E + ++ K +++ + ++ + K KN +K ++ E
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 502 AYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLT------QGEV--AAGMV--- 550
+G +HK ++E ++ E++ K E +L Q EV GM+
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306
Query: 551 ------LQKKLYSIYEVQALERKELI----KNRAICAMSLAELQEPLL----QLEDEAER 596
L K + S+ Q + +EL+ + + + L +L+E QL++E E
Sbjct: 1307 EGKAIKLAKDVASL-SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365
Query: 597 IRSLDKEHSVMLNNIIDQKDLIRRKVGKVK--KKLRKKGKKTLDALIETESKRSAIFKDL 654
++L++ S + + D K ++ V+ ++ +K+ +K ++ L + +++A + L
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1425
Query: 655 EATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYM 714
E TK N L +EL ++ D +++ N E Q FD +
Sbjct: 1426 EKTK----------NRLQQEL---DDLVVDLDNQRQLVSN--------LEKKQRKFDQLL 1464
Query: 715 QEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEK 774
E+K+ + D+R R R+K + +A +LEE L +E ++ E
Sbjct: 1465 AEEKNISSKY--ADERDRAEAEAREKETKALS--LARALEEALEAKEELERTNKMLKAEM 1520
Query: 775 D-----------NYFNIYDKQLSLDTSIRD-KKQLCQLQRRMHTLWQEHFKLVVLFSQMR 822
+ N + + +L+T + + K QL +L+ + +L V ++
Sbjct: 1521 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1580
Query: 823 LANFQTDSQESIQKILAVQEESSNLMQHILGFFQT 857
F+ D Q ++ EE +Q L ++T
Sbjct: 1581 -GQFERDLQARDEQ----NEEKRRQLQRQLHEYET 1610
Score = 70.9 bits (172), Expect = 5e-12
Identities = 123/591 (20%), Positives = 258/591 (43%), Gaps = 77/591 (13%)
Query: 105 DVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPE-LKQEM 163
D E + +++L+R ++ + S +K +D++ T V+ ++ G+KR +K E L Q+
Sbjct: 1360 DEEMEAKQNLERHISTLN--IQLSDSKKKLQDFAST--VEALEEGKKRFQKEIENLTQQY 1415
Query: 164 ETLLSEAIRLIKS---LETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQ-- 218
E + +L K+ L+ + D L QR + + K + +E ++ +
Sbjct: 1416 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475
Query: 219 KEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQN 278
E + ++ E + A L+ + K ELE N ++A+++ L+ SK +
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME------DLVSSKDD 1529
Query: 279 -----QELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKA----QQIKEEIDKD 329
EL+ K + +ME M EELE+ L+A E+A+L+ Q +K + ++D
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQL---EELEDELQATEDAKLRLEVNMQALKGQFERD 1586
Query: 330 IY----QDEKTIEAYKREIYQLNS-LFDHYSSSVI------NVNTNIEEKEEEVT----- 373
+ Q+E+ +R++++ + L D + + ++++ E +
Sbjct: 1587 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646
Query: 374 --EAIRETKSSKNELHSLSKMLEDLRRVYDQL-------TWKQKSHENQYLEAVNDFYAA 424
EAI++ + + ++ + LED R D++ K KS E ++ D AA
Sbjct: 1647 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706
Query: 425 ---KKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEI 481
+K D+E ++A++ ++ L ++ ++LE I ++ + E +
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766
Query: 482 KYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAE----VRRKFKGR---- 533
+ T + L A + + + + E+ K+ E V+ KFK
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826
Query: 534 -------EEFLKKLTQGEVAAGMVLQKKLYSIYEVQAL---ERK--ELIKNRAICAMS-L 580
EE +++ + + AA L++K + E+ ERK E K +A + +
Sbjct: 1827 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1886
Query: 581 AELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRK 631
+L+ L + E+E++RI + ++ L+ + + + R+V +K KLR+
Sbjct: 1887 KQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937
Score = 54.7 bits (130), Expect = 4e-07
Identities = 98/492 (19%), Positives = 206/492 (41%), Gaps = 67/492 (13%)
Query: 97 NKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKC 156
+++++ +++ SK + R E +R TK L S+ ++E ++ E+
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAE----AREKETKAL----SLARALEEALEAKEELERT 1512
Query: 157 PE-LKQEMETLLS---EAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQE 212
+ LK EME L+S + + + LE + E +++ +++ + ++ + KL+
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR- 1571
Query: 213 LPLAVQKEHEAYLSDVIELQWHLEDKANQLQH-FEKQKTELEE----------ANAKIQA 261
L + +Q + D+ E+K QLQ + +TELE+ A K++
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 262 DIDYMNEH------GPLLDSKQNQELQDLKNHYKKKMEVMDLHR-------KVNE----- 303
D+ + G KQ ++LQ +++++E R K NE
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691
Query: 304 ------ELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSS 357
+L+E L A E AR +A KEE+ +++ A + E +L +
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Query: 358 VINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEA 417
+ N+E + V +A ++ + NEL + ++ T ++ Q LE
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELAT------------ERSTAQKNESARQQLER 1799
Query: 418 VNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKY 477
N K ++E + +K S I+ K+ + +++E + + T +S+++K K
Sbjct: 1800 QNK-ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT-KSLKQKDKK 1857
Query: 478 ESEIKYLTIMKLKNDKHLKNIYKEAYRIGTL-FHLTKHKTDEMEDKIAEVRRKFKGREEF 536
EI ++++++++ + YKE G K + +E E++ + + +
Sbjct: 1858 LKEI----LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1913
Query: 537 LKKLTQGEVAAG 548
L + T+ A G
Sbjct: 1914 LDEATESNEAMG 1925
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 81.3 bits (199), Expect = 4e-15
Identities = 121/637 (18%), Positives = 257/637 (40%), Gaps = 59/637 (9%)
Query: 161 QEMETLLSEAIRL-------IKSLETDRADAEEALKQQRSRKNMINMKIDSWSVW----- 208
Q+ + LL E R ++ LE +R ++ L ++ K + I + ++
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 209 -KLQELPLAVQKEHEA---YLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADID 264
KLQ+ V+ E + ++ L E+KA EK K L++ + D+D
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444
Query: 265 YMNEHGPLLDSKQ---NQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQ 321
+ L+ KQ +Q L + KN K + D E E + A +A +
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504
Query: 322 IKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKS 381
KEE+ E+T + K E+ L S D +V + + E ++ E + +
Sbjct: 1505 AKEEL-------ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557
Query: 382 SKNELHSLS----KMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAK 437
++EL + ++ +++ + Q ++ + Q E ++ EL D K
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617
Query: 438 DFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKN 497
+ + A KL D K LE+ + E+I++ K ++++K + L++
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF-------QRELED 1670
Query: 498 IYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYS 557
I + K +E + +++ E K Q ++ + ++ S
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK---QADLEKEELAEELASS 1727
Query: 558 IYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDL 617
+ AL+ E + A A EL+E +E ++R+R ++ + N + ++
Sbjct: 1728 LSGRNALQ-DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1786
Query: 618 IRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELKA 677
++ +++L ++ K+ L E E + FK A AKI +L E+++
Sbjct: 1787 AQKNES-ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE------AKIAQLEEQVEQ 1839
Query: 678 KEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEK-------KDCEERIFEEDQR 730
+ EK++ ++L+ K + + E + + + Y ++ K + ++ E ++
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
Query: 731 FRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQ 767
+ + A R+K Q+ + ++ E N + +E L+
Sbjct: 1900 SQRINANRRK----LQRELDEATESNEAMGREVNALK 1932
Score = 80.5 bits (197), Expect = 6e-15
Identities = 155/737 (21%), Positives = 314/737 (42%), Gaps = 113/737 (15%)
Query: 98 KMISHIQDVESKIQEH-LKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKC 156
KM + D+E +++E R + E+ + + K L+++ V D++
Sbjct: 954 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM------------DDQN 1001
Query: 157 PELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLA 216
+L +E + LL E I L T+ A+ EE K KN I EL +
Sbjct: 1002 NKLSKERK-LLEERI---SDLTTNLAEEEEKAKNLTKLKNKHESMIS--------ELEVR 1049
Query: 217 VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSK 276
++KE ++ ++ +L+ LE A+ F +Q +L+ A+++ + E ++
Sbjct: 1050 LKKEEKSR-QELEKLKRKLEGDASD---FHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105
Query: 277 QNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKT 336
+ E+ KN+ KK+ ++ H +L+E L++ AR KA++ K ++ +++
Sbjct: 1106 LDDEIAQ-KNNALKKIRELEGHIS---DLQEDLDSERAARNKAEKQKRDLGEEL------ 1155
Query: 337 IEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDL 396
EA K E L D S+ + +E+EVT K+ E S ++++
Sbjct: 1156 -EALKTE------LEDTLDSTATQQELRAK-REQEVTVL---KKALDEETRSHEAQVQEM 1204
Query: 397 RRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKL 456
R+ + Q + Q+ A + K+T + E +D+A + + A ++ KKL
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 457 EIDINKITVKTNESIR-------KKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLF 509
E + ++ K ++ R K K ++E++ +T M + + + K+ + +
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 510 HLTKHKTDEMEDKIAEVRRKFKGREE---FLKKLTQGEVAAGMVLQKKLYSIYEVQALER 566
T+ E + V K + EE L+ E+ A L++ + S +Q +
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI-STLNIQLSDS 1383
Query: 567 KELIKNRAICAMSL--------AELQEPLLQLEDEAERIRSLDKEHSVM---LNNIIDQK 615
K+ +++ A +L E++ Q E++A L+K + + L++++
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1443
Query: 616 DLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKD------LEATKSKTMIFYAKIN 669
D R+ V ++KK RK D L+ E S+ + D EA + +T +
Sbjct: 1444 DNQRQLVSNLEKKQRK-----FDQLLAEEKNISSKYADERDRAEAEAREKETKAL-SLAR 1497
Query: 670 ELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQ 729
L E L+AKEE ++T ++LK + + + K D + + E ++
Sbjct: 1498 ALEEALEAKEE----LERTNKMLKAE--------------MEDLVSSKDDVGKNVHELEK 1539
Query: 730 RFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQ-QLQITFLKEKDNYFNIYDKQLSLD 788
R L +T + K + LE+ L+ ++ + +L++ K +++ L
Sbjct: 1540 SKRAL-----ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ----FERDLQAR 1590
Query: 789 TSIRDKKQLCQLQRRMH 805
++K+ QLQR++H
Sbjct: 1591 DEQNEEKRR-QLQRQLH 1606
Score = 73.2 bits (178), Expect = 1e-12
Identities = 157/815 (19%), Positives = 330/815 (40%), Gaps = 119/815 (14%)
Query: 120 SFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLET 179
+++ W + K L + VT +E++ E +K E +Q+ E L E ++ +
Sbjct: 838 NWQWWRLFTKVKPLLQ---VTRQEEEMQAKEDELQKTKERQQKAENELKE----LEQKHS 890
Query: 180 DRADAEEALKQQRSRKNMINMKIDSWSVW---KLQELPLAVQKEHEAYLSDVIE----LQ 232
+ + L++Q + + + + V K QEL + E EA L + + LQ
Sbjct: 891 QLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQ 949
Query: 233 WHLEDKANQLQHFEKQKTELEEANAKIQ-------ADIDYMNEHGPLLDSKQN------- 278
+ A Q+ E+Q E E A K+Q A I + + ++D + N
Sbjct: 950 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 279 ---QELQDLKNHYKKKME-------VMDLHRKVNEELEEALEACENARLKAQQIKEEIDK 328
+ + DL + ++ E + + H + ELE L+ E +R + +++K +++
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1069
Query: 329 DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHS 388
D + I + +I +L + ++++ + A+++ + + +
Sbjct: 1070 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 389 LSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDV---AKDFSAISLA 445
L + L+ R ++ KQK + LEA+ + T D + AK +++
Sbjct: 1130 LQEDLDSERAARNKAE-KQKRDLGEELEALKT--ELEDTLDSTATQQELRAKREQEVTVL 1186
Query: 446 CTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKN----DKHLKNIYKE 501
L E+ + E + ++ K +++ + ++ + K KN +K ++ E
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 502 AYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLT------QGEV--AAGMV--- 550
+G +HK ++E ++ E++ K E +L Q EV GM+
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306
Query: 551 ------LQKKLYSIYEVQALERKELI----KNRAICAMSLAELQEPLL----QLEDEAER 596
L K + S+ Q + +EL+ + + + L +L+E QL++E E
Sbjct: 1307 EGKAIKLAKDVASL-SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365
Query: 597 IRSLDKEHSVMLNNIIDQKDLIRRKVGKVK--KKLRKKGKKTLDALIETESKRSAIFKDL 654
++L++ S + + D K ++ V+ ++ +K+ +K ++ L + +++A + L
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1425
Query: 655 EATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYM 714
E TK N L +EL ++ D +++ N E Q FD +
Sbjct: 1426 EKTK----------NRLQQEL---DDLVVDLDNQRQLVSN--------LEKKQRKFDQLL 1464
Query: 715 QEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEK 774
E+K+ + D+R R R+K + +A +LEE L +E ++ E
Sbjct: 1465 AEEKNISSKY--ADERDRAEAEAREKETKALS--LARALEEALEAKEELERTNKMLKAEM 1520
Query: 775 D-----------NYFNIYDKQLSLDTSIRD-KKQLCQLQRRMHTLWQEHFKLVVLFSQMR 822
+ N + + +L+T + + K QL +L+ + +L V ++
Sbjct: 1521 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1580
Query: 823 LANFQTDSQESIQKILAVQEESSNLMQHILGFFQT 857
F+ D Q ++ EE +Q L ++T
Sbjct: 1581 -GQFERDLQARDEQ----NEEKRRQLQRQLHEYET 1610
Score = 70.1 bits (170), Expect = 8e-12
Identities = 123/590 (20%), Positives = 257/590 (43%), Gaps = 77/590 (13%)
Query: 105 DVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPE-LKQEM 163
D E + +++L+R ++ + S +K +D++ T V+ ++ G+KR +K E L Q+
Sbjct: 1360 DEEMEAKQNLERHISTLN--IQLSDSKKKLQDFAST--VEALEEGKKRFQKEIENLTQQY 1415
Query: 164 ETLLSEAIRLIKS---LETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQ-- 218
E + +L K+ L+ + D L QR + + K + +E ++ +
Sbjct: 1416 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475
Query: 219 KEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQN 278
E + ++ E + A L+ + K ELE N ++A+++ L+ SK +
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME------DLVSSKDD 1529
Query: 279 -----QELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKA----QQIKEEIDKD 329
EL+ K + +ME M EELE+ L+A E+A+L+ Q +K + ++D
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQL---EELEDELQATEDAKLRLEVNMQALKGQFERD 1586
Query: 330 IY----QDEKTIEAYKREIYQLNS-LFDHYSSSVI------NVNTNIEEKEEEVT----- 373
+ Q+E+ +R++++ + L D + + ++++ E +
Sbjct: 1587 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646
Query: 374 --EAIRETKSSKNELHSLSKMLEDLRRVYDQL-------TWKQKSHENQYLEAVNDFYAA 424
EAI++ + + ++ + LED R D++ K KS E ++ D AA
Sbjct: 1647 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706
Query: 425 ---KKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEI 481
+K D+E ++A++ ++ L ++ ++LE I ++ + E +
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766
Query: 482 KYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAE----VRRKFKGR---- 533
+ T + L A + + + + E+ K+ E V+ KFK
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826
Query: 534 -------EEFLKKLTQGEVAAGMVLQKKLYSIYEVQAL---ERK--ELIKNRAICAMS-L 580
EE +++ + + AA L++K + E+ ERK E K +A + +
Sbjct: 1827 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1886
Query: 581 AELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLR 630
+L+ L + E+E++RI + ++ L+ + + + R+V +K KLR
Sbjct: 1887 KQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 54.7 bits (130), Expect = 4e-07
Identities = 98/492 (19%), Positives = 206/492 (41%), Gaps = 67/492 (13%)
Query: 97 NKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKC 156
+++++ +++ SK + R E +R TK L S+ ++E ++ E+
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAE----AREKETKAL----SLARALEEALEAKEELERT 1512
Query: 157 PE-LKQEMETLLS---EAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQE 212
+ LK EME L+S + + + LE + E +++ +++ + ++ + KL+
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR- 1571
Query: 213 LPLAVQKEHEAYLSDVIELQWHLEDKANQLQH-FEKQKTELEE----------ANAKIQA 261
L + +Q + D+ E+K QLQ + +TELE+ A K++
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 262 DIDYMNEH------GPLLDSKQNQELQDLKNHYKKKMEVMDLHR-------KVNE----- 303
D+ + G KQ ++LQ +++++E R K NE
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691
Query: 304 ------ELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSS 357
+L+E L A E AR +A KEE+ +++ A + E +L +
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Query: 358 VINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEA 417
+ N+E + V +A ++ + NEL + ++ T ++ Q LE
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELAT------------ERSTAQKNESARQQLER 1799
Query: 418 VNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKY 477
N K ++E + +K S I+ K+ + +++E + + T +S+++K K
Sbjct: 1800 QNK-ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT-KSLKQKDKK 1857
Query: 478 ESEIKYLTIMKLKNDKHLKNIYKEAYRIGTL-FHLTKHKTDEMEDKIAEVRRKFKGREEF 536
EI ++++++++ + YKE G K + +E E++ + + +
Sbjct: 1858 LKEI----LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1913
Query: 537 LKKLTQGEVAAG 548
L + T+ A G
Sbjct: 1914 LDEATESNEAMG 1925
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 81.3 bits (199), Expect = 4e-15
Identities = 121/637 (18%), Positives = 257/637 (40%), Gaps = 59/637 (9%)
Query: 161 QEMETLLSEAIRL-------IKSLETDRADAEEALKQQRSRKNMINMKIDSWSVW----- 208
Q+ + LL E R ++ LE +R ++ L ++ K + I + ++
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377
Query: 209 -KLQELPLAVQKEHEA---YLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADID 264
KLQ+ V+ E + ++ L E+KA EK K L++ + D+D
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437
Query: 265 YMNEHGPLLDSKQ---NQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQ 321
+ L+ KQ +Q L + KN K + D E E + A +A +
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497
Query: 322 IKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKS 381
KEE+ E+T + K E+ L S D +V + + E ++ E + +
Sbjct: 1498 AKEEL-------ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550
Query: 382 SKNELHSLS----KMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAK 437
++EL + ++ +++ + Q ++ + Q E ++ EL D K
Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610
Query: 438 DFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKN 497
+ + A KL D K LE+ + E+I++ K ++++K + L++
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF-------QRELED 1663
Query: 498 IYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYS 557
I + K +E + +++ E K Q ++ + ++ S
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK---QADLEKEELAEELASS 1720
Query: 558 IYEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDL 617
+ AL+ E + A A EL+E +E ++R+R ++ + N + ++
Sbjct: 1721 LSGRNALQ-DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1779
Query: 618 IRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELKA 677
++ +++L ++ K+ L E E + FK A AKI +L E+++
Sbjct: 1780 AQKNES-ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE------AKIAQLEEQVEQ 1832
Query: 678 KEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEK-------KDCEERIFEEDQR 730
+ EK++ ++L+ K + + E + + + Y ++ K + ++ E ++
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
Query: 731 FRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQ 767
+ + A R+K Q+ + ++ E N + +E L+
Sbjct: 1893 SQRINANRRK----LQRELDEATESNEAMGREVNALK 1925
Score = 80.5 bits (197), Expect = 6e-15
Identities = 155/737 (21%), Positives = 314/737 (42%), Gaps = 113/737 (15%)
Query: 98 KMISHIQDVESKIQEH-LKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKC 156
KM + D+E +++E R + E+ + + K L+++ V D++
Sbjct: 947 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM------------DDQN 994
Query: 157 PELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLA 216
+L +E + LL E I L T+ A+ EE K KN I EL +
Sbjct: 995 NKLSKERK-LLEERI---SDLTTNLAEEEEKAKNLTKLKNKHESMIS--------ELEVR 1042
Query: 217 VQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSK 276
++KE ++ ++ +L+ LE A+ F +Q +L+ A+++ + E ++
Sbjct: 1043 LKKEEKSR-QELEKLKRKLEGDASD---FHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098
Query: 277 QNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKT 336
+ E+ KN+ KK+ ++ H +L+E L++ AR KA++ K ++ +++
Sbjct: 1099 LDDEIAQ-KNNALKKIRELEGHIS---DLQEDLDSERAARNKAEKQKRDLGEEL------ 1148
Query: 337 IEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDL 396
EA K E L D S+ + +E+EVT K+ E S ++++
Sbjct: 1149 -EALKTE------LEDTLDSTATQQELRAK-REQEVTVL---KKALDEETRSHEAQVQEM 1197
Query: 397 RRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKL 456
R+ + Q + Q+ A + K+T + E +D+A + + A ++ KKL
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 457 EIDINKITVKTNESIR-------KKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLF 509
E + ++ K ++ R K K ++E++ +T M + + + K+ + +
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 510 HLTKHKTDEMEDKIAEVRRKFKGREE---FLKKLTQGEVAAGMVLQKKLYSIYEVQALER 566
T+ E + V K + EE L+ E+ A L++ + S +Q +
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI-STLNIQLSDS 1376
Query: 567 KELIKNRAICAMSL--------AELQEPLLQLEDEAERIRSLDKEHSVM---LNNIIDQK 615
K+ +++ A +L E++ Q E++A L+K + + L++++
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1436
Query: 616 DLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKD------LEATKSKTMIFYAKIN 669
D R+ V ++KK RK D L+ E S+ + D EA + +T +
Sbjct: 1437 DNQRQLVSNLEKKQRK-----FDQLLAEEKNISSKYADERDRAEAEAREKETKAL-SLAR 1490
Query: 670 ELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQ 729
L E L+AKEE ++T ++LK + + + K D + + E ++
Sbjct: 1491 ALEEALEAKEE----LERTNKMLKAE--------------MEDLVSSKDDVGKNVHELEK 1532
Query: 730 RFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQ-QLQITFLKEKDNYFNIYDKQLSLD 788
R L +T + K + LE+ L+ ++ + +L++ K +++ L
Sbjct: 1533 SKRAL-----ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ----FERDLQAR 1583
Query: 789 TSIRDKKQLCQLQRRMH 805
++K+ QLQR++H
Sbjct: 1584 DEQNEEKRR-QLQRQLH 1599
Score = 73.2 bits (178), Expect = 1e-12
Identities = 157/815 (19%), Positives = 330/815 (40%), Gaps = 119/815 (14%)
Query: 120 SFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLET 179
+++ W + K L + VT +E++ E +K E +Q+ E L E ++ +
Sbjct: 831 NWQWWRLFTKVKPLLQ---VTRQEEEMQAKEDELQKTKERQQKAENELKE----LEQKHS 883
Query: 180 DRADAEEALKQQRSRKNMINMKIDSWSVW---KLQELPLAVQKEHEAYLSDVIE----LQ 232
+ + L++Q + + + + V K QEL + E EA L + + LQ
Sbjct: 884 QLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQ 942
Query: 233 WHLEDKANQLQHFEKQKTELEEANAKIQ-------ADIDYMNEHGPLLDSKQN------- 278
+ A Q+ E+Q E E A K+Q A I + + ++D + N
Sbjct: 943 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 279 ---QELQDLKNHYKKKME-------VMDLHRKVNEELEEALEACENARLKAQQIKEEIDK 328
+ + DL + ++ E + + H + ELE L+ E +R + +++K +++
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1062
Query: 329 DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHS 388
D + I + +I +L + ++++ + A+++ + + +
Sbjct: 1063 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 389 LSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDV---AKDFSAISLA 445
L + L+ R ++ KQK + LEA+ + T D + AK +++
Sbjct: 1123 LQEDLDSERAARNKAE-KQKRDLGEELEALKT--ELEDTLDSTATQQELRAKREQEVTVL 1179
Query: 446 CTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKN----DKHLKNIYKE 501
L E+ + E + ++ K +++ + ++ + K KN +K ++ E
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 502 AYRIGTLFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKLT------QGEV--AAGMV--- 550
+G +HK ++E ++ E++ K E +L Q EV GM+
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299
Query: 551 ------LQKKLYSIYEVQALERKELI----KNRAICAMSLAELQEPLL----QLEDEAER 596
L K + S+ Q + +EL+ + + + L +L+E QL++E E
Sbjct: 1300 EGKAIKLAKDVASL-SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358
Query: 597 IRSLDKEHSVMLNNIIDQKDLIRRKVGKVK--KKLRKKGKKTLDALIETESKRSAIFKDL 654
++L++ S + + D K ++ V+ ++ +K+ +K ++ L + +++A + L
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1418
Query: 655 EATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYM 714
E TK N L +EL ++ D +++ N E Q FD +
Sbjct: 1419 EKTK----------NRLQQEL---DDLVVDLDNQRQLVSN--------LEKKQRKFDQLL 1457
Query: 715 QEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEK 774
E+K+ + D+R R R+K + +A +LEE L +E ++ E
Sbjct: 1458 AEEKNISSKY--ADERDRAEAEAREKETKALS--LARALEEALEAKEELERTNKMLKAEM 1513
Query: 775 D-----------NYFNIYDKQLSLDTSIRD-KKQLCQLQRRMHTLWQEHFKLVVLFSQMR 822
+ N + + +L+T + + K QL +L+ + +L V ++
Sbjct: 1514 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1573
Query: 823 LANFQTDSQESIQKILAVQEESSNLMQHILGFFQT 857
F+ D Q ++ EE +Q L ++T
Sbjct: 1574 -GQFERDLQARDEQ----NEEKRRQLQRQLHEYET 1603
Score = 70.1 bits (170), Expect = 8e-12
Identities = 123/590 (20%), Positives = 257/590 (43%), Gaps = 77/590 (13%)
Query: 105 DVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPE-LKQEM 163
D E + +++L+R ++ + S +K +D++ T V+ ++ G+KR +K E L Q+
Sbjct: 1353 DEEMEAKQNLERHISTLN--IQLSDSKKKLQDFAST--VEALEEGKKRFQKEIENLTQQY 1408
Query: 164 ETLLSEAIRLIKS---LETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQ-- 218
E + +L K+ L+ + D L QR + + K + +E ++ +
Sbjct: 1409 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468
Query: 219 KEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQN 278
E + ++ E + A L+ + K ELE N ++A+++ L+ SK +
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME------DLVSSKDD 1522
Query: 279 -----QELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKA----QQIKEEIDKD 329
EL+ K + +ME M EELE+ L+A E+A+L+ Q +K + ++D
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQL---EELEDELQATEDAKLRLEVNMQALKGQFERD 1579
Query: 330 IY----QDEKTIEAYKREIYQLNS-LFDHYSSSVI------NVNTNIEEKEEEVT----- 373
+ Q+E+ +R++++ + L D + + ++++ E +
Sbjct: 1580 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639
Query: 374 --EAIRETKSSKNELHSLSKMLEDLRRVYDQL-------TWKQKSHENQYLEAVNDFYAA 424
EAI++ + + ++ + LED R D++ K KS E ++ D AA
Sbjct: 1640 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699
Query: 425 ---KKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEI 481
+K D+E ++A++ ++ L ++ ++LE I ++ + E +
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759
Query: 482 KYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAE----VRRKFKGR---- 533
+ T + L A + + + + E+ K+ E V+ KFK
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819
Query: 534 -------EEFLKKLTQGEVAAGMVLQKKLYSIYEVQAL---ERK--ELIKNRAICAMS-L 580
EE +++ + + AA L++K + E+ ERK E K +A + +
Sbjct: 1820 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1879
Query: 581 AELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLR 630
+L+ L + E+E++RI + ++ L+ + + + R+V +K KLR
Sbjct: 1880 KQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 54.7 bits (130), Expect = 4e-07
Identities = 98/492 (19%), Positives = 206/492 (41%), Gaps = 67/492 (13%)
Query: 97 NKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKC 156
+++++ +++ SK + R E +R TK L S+ ++E ++ E+
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAE----AREKETKAL----SLARALEEALEAKEELERT 1505
Query: 157 PE-LKQEMETLLS---EAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQE 212
+ LK EME L+S + + + LE + E +++ +++ + ++ + KL+
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR- 1564
Query: 213 LPLAVQKEHEAYLSDVIELQWHLEDKANQLQH-FEKQKTELEE----------ANAKIQA 261
L + +Q + D+ E+K QLQ + +TELE+ A K++
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624
Query: 262 DIDYMNEH------GPLLDSKQNQELQDLKNHYKKKMEVMDLHR-------KVNE----- 303
D+ + G KQ ++LQ +++++E R K NE
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684
Query: 304 ------ELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSS 357
+L+E L A E AR +A KEE+ +++ A + E +L +
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 358 VINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEA 417
+ N+E + V +A ++ + NEL + ++ T ++ Q LE
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELAT------------ERSTAQKNESARQQLER 1792
Query: 418 VNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKY 477
N K ++E + +K S I+ K+ + +++E + + T +S+++K K
Sbjct: 1793 QNK-ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT-KSLKQKDKK 1850
Query: 478 ESEIKYLTIMKLKNDKHLKNIYKEAYRIGTL-FHLTKHKTDEMEDKIAEVRRKFKGREEF 536
EI ++++++++ + YKE G K + +E E++ + + +
Sbjct: 1851 LKEI----LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1906
Query: 537 LKKLTQGEVAAG 548
L + T+ A G
Sbjct: 1907 LDEATESNEAMG 1918
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 80.9 bits (198), Expect = 5e-15
Identities = 161/762 (21%), Positives = 334/762 (43%), Gaps = 130/762 (17%)
Query: 142 PVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMK 201
PV E K E + + E LL I+S +E S K + +
Sbjct: 270 PVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQS-------HKEQCTLLTSEKEALQEQ 322
Query: 202 IDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQK-TELEEANAKIQ 260
+D +LQEL +K + ++++ +L L D N ++ E+ K + E ++
Sbjct: 323 LDE----RLQEL----EKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMH 374
Query: 261 ADIDYMNEHGPLLDSK------QNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACEN 314
++ E L S+ Q +EL++ K+K E R EELE+AL +
Sbjct: 375 ETLEMKEEEIAQLRSRIKQMTTQGEELRE----QKEKSE-----RAAFEELEKALSTAQK 425
Query: 315 ARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTE 374
+++K E+D+ I EKT E + I++ + ++EV +
Sbjct: 426 TEEARRKLKAEMDEQIKTIEKTSEEER-----------------ISLQQELSRVKQEVVD 468
Query: 375 AIRETKSSKNELHSLSKMLE-DLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELS 433
++ KSS+ ++ L K+ E +L R +LT K ++ E ++ E + ++ +++S
Sbjct: 469 VMK--KSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS 526
Query: 434 DVAKDFSAISLACTK------LTEDNKKL-----EIDINKITVKTNESIRKKSKYE--SE 480
+ +++L + LTE KL E + + + ES +KS E ++
Sbjct: 527 QEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQ 586
Query: 481 IKYLTI-MKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEM-EDKIAEVRRKFKGREEFLK 538
K L + ++ + +KH K I + T KH+ D + +K+ ++++++ E L+
Sbjct: 587 SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR 646
Query: 539 KLTQGEVAAGMVLQKKLYSIYEVQALERKEL----IKNRAICAMS--LAE-------LQE 585
+ + E ++ K++ ++ + K L +K + ++S L+E L+E
Sbjct: 647 EKCEQEKET-LLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEE 705
Query: 586 PLLQLEDEAERIR-----SLDKE---HSVMLNNIIDQKDLIRRKVGKVKK---------- 627
L L+D+ ++++ +D++ H +++II + ++ ++ K K
Sbjct: 706 ELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLL 765
Query: 628 KLRKKGKKTLDALI---ETESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKS 684
K R K K A + E + KRS +L+ +K +F + + +E+ KA EE+
Sbjct: 766 KERDKHLKEHQAHVENLEADIKRSE--GELQQASAKLDVFQSYQSATHEQTKAYEEQLAQ 823
Query: 685 FDQTLEILKNK--FITMRFKREHAQ-----TVFDHYMQEKKD----CEERIFEEDQRFRV 733
Q L L+ + +T + AQ T D + + +D E++ E +Q+ +
Sbjct: 824 LQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKS 883
Query: 734 LLAVRQKTLQD-------TQKIIADSLEENLRL-AQEYQQLQITFLKE----KDNYFNIY 781
L V + L+D T++I+ + +EN+ L +E Q+ +I L + K++ +I
Sbjct: 884 LTQVYESKLEDGNKEQEQTKQILVE--KENMILQMREGQKKEIEILTQKLSAKEDSIHIL 941
Query: 782 DKQLSLDTSIRDKKQLCQLQRRMHTLWQEHFKLVVLFSQMRL 823
+++ +T +++++ + ++ QE K +L + +L
Sbjct: 942 NEE--YETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKL 981
Score = 67.4 bits (163), Expect = 5e-11
Identities = 148/760 (19%), Positives = 323/760 (42%), Gaps = 105/760 (13%)
Query: 161 QEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKE 220
Q T + EA+ LIK+ +A+ L+Q +N +N+ + +L+E ++
Sbjct: 1254 QHRTTKVKEAL-LIKTCTVSELEAQ--LRQLTEEQNTLNISFQQ-ATHQLEEKENQIKSM 1309
Query: 221 HEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQ--- 277
S V E + ++ NQ Q ++++ + + ++ +I+ + L K+
Sbjct: 1310 KADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEI 1369
Query: 278 ----------NQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQQIKEEID 327
N +LQ+ + +K+ + L ++ +EE E L+ ++ K + +E
Sbjct: 1370 SSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKI 1429
Query: 328 KDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELH 387
+ Q + + + S F + ++V + +E K +E E + K EL
Sbjct: 1430 SALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELD 1489
Query: 388 SLSKMLEDLR-RVYDQLTWKQKSHENQYLEAVN--------DFYAAKKTWDIE-LSDVAK 437
+K + L+ + D + +K N E + + + +KT +IE L++V K
Sbjct: 1490 QQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLK 1549
Query: 438 DFS-AISLACTKLTE------------DNKKLEIDINKITVKTNESIRKKSKYES---EI 481
+++ + +L + DN+ E + KI N+ K++ E+ E+
Sbjct: 1550 NYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAE-EKILTLENQVYSMKAELETKKKEL 1608
Query: 482 KYLTIMKLKNDKHLKNIYK--EAYRIGTLFHLTKHKTDEMEDKIAEVRRKF--------- 530
+++ + ++ LK + E+ L L + + E KIA ++++
Sbjct: 1609 EHVNLSVKSKEEELKALEDRLESESAAKLAELKR----KAEQKIAAIKKQLLSQMEEKEE 1664
Query: 531 ---KGREEFLKKLT---QGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQ 584
KG E L +L Q +L++KL S V++ + + LI R+ ++ Q
Sbjct: 1665 QYKKGTESHLSELNTKLQEREREVHILEEKLKS---VESSQSETLIVPRSAKNVAAYTEQ 1721
Query: 585 EPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKK-------KLRKKGKKTL 637
E + + + ++ +++ SV+ N+ +++ L++R VG+ K+ ++R + ++ L
Sbjct: 1722 E---EADSQGCVQKTYEEKISVLQRNLTEKEKLLQR-VGQEKEETVSSHFEMRCQYQERL 1777
Query: 638 DALIETESKR-------SAIFKDLEATKSKTMIFYAKINEL---NEELKAKEEEKKSFDQ 687
L E+K+ + ++LE K + A+ E ++AK+ + FD
Sbjct: 1778 IKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDD 1837
Query: 688 TLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQK 747
+ L+ K +T + + + + +++K+ + E ++ L A++Q D +
Sbjct: 1838 VQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQ---MDGRN 1894
Query: 748 IIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSLDTSIRDK----KQLCQLQRR 803
+ LEEN + +Q L + N D + L + R+K K++ +LQ+
Sbjct: 1895 KPTELLEENTEEKSKSHLVQPKLLSNMEAQHN--DLEFKLAGAEREKQKLGKEIVRLQKD 1952
Query: 804 MHTLWQEHFKLVVLFSQMRLANFQTDSQESIQKILAVQEE 843
+ L +EH + ++ + + D QE +KI QE+
Sbjct: 1953 LRMLRKEHQQ------ELEILKKEYD-QEREEKIKQEQED 1985
Score = 67.4 bits (163), Expect = 5e-11
Identities = 126/643 (19%), Positives = 265/643 (41%), Gaps = 85/643 (13%)
Query: 101 SHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELK 160
+ I ++E I + E+ E + KD++ V + GE++D + E +
Sbjct: 1525 ARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAE 1584
Query: 161 QEMETLLSEAIRLIKSLETDRADAEE---ALKQQRSRKNMINMKIDSWSVWKLQELPLAV 217
+++ TL ++ + LET + + E ++K + + +++S S KL EL
Sbjct: 1585 EKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKA 1644
Query: 218 QKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQ---ADIDYMNEHGPLLD 274
+++ A ++ +E+K Q + + ++ L E N K+Q ++ + E ++
Sbjct: 1645 EQKIAAIKKQLLS---QMEEKEEQYK--KGTESHLSELNTKLQEREREVHILEEKLKSVE 1699
Query: 275 SKQNQEL---QDLKN------------------HYKKKMEVMD--------LHRKVNEEL 305
S Q++ L + KN Y++K+ V+ L ++V +E
Sbjct: 1700 SSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEK 1759
Query: 306 EEALEACENARLKAQQ--IK-EEIDKDIYQDEKTIEAYKREIYQLNSLFD---------H 353
EE + + R + Q+ IK E + ++D+ I + E+ + N +
Sbjct: 1760 EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKE 1819
Query: 354 YSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDL---RRVYDQLTWKQKSH 410
+ I N+E ++V + ++E + + L K L+ ++ ++ ++ +
Sbjct: 1820 GGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTS 1879
Query: 411 ENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNES 470
+ + L+A+ K ++ L + ++ S L KL + +E N + K +
Sbjct: 1880 KYEKLQALQQMDGRNKPTEL-LEENTEEKSKSHLVQPKLLSN---MEAQHNDLEFKLAGA 1935
Query: 471 IRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAEVRRKF 530
R+K K EI ++ K L+ + KE + L L K E E+KI + +
Sbjct: 1936 EREKQKLGKEI-------VRLQKDLRMLRKEHQQ--ELEILKKEYDQEREEKIKQEQEDL 1986
Query: 531 KGR---------EEFLKKLTQGEVAAGMVLQKKLYSIYEVQA--LERKELIKNRAICAMS 579
+ + EF +L Q E M +++ + EV+A LE + N+ +
Sbjct: 1987 ELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLL--KK 2044
Query: 580 LAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLD- 638
+AE + L + E I LD M + D + + K ++KL ++ D
Sbjct: 2045 IAEKDDDLKRTAKRYEEI--LDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDN 2102
Query: 639 -ALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEE 680
++E +++ + + +K K F +I+ L + LK E+
Sbjct: 2103 VTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEK 2145
Score = 63.9 bits (154), Expect = 6e-10
Identities = 175/850 (20%), Positives = 344/850 (40%), Gaps = 122/850 (14%)
Query: 24 QEVKALREKAWSRTNEGNAMSQSLVLYGASKENSEGFHESKMTNTEGVNKGIYF---SYP 80
Q+VK+L + S+ +GN + KEN + EG K I
Sbjct: 879 QKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMI------LQMREGQKKEIEILTQKLS 932
Query: 81 CRRHSCAVVNIPAPCVNKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVT 140
+ S ++N + + ++ E K+++ ++ + E + ++ K +
Sbjct: 933 AKEDSIHILN------EEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELE 986
Query: 141 TPVKEVKPGEKR-DEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQRSRKNMIN 199
E+ EK+ + K E+ Q +S+A+ LET++ + E+L + R+ +N
Sbjct: 987 NTALELSQKEKQFNAKMLEMAQANSAGISDAV---SRLETNQKEQIESLTEVHRRE--LN 1041
Query: 200 MKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKI 259
I W KL + +Q+ HE I+LQ ++ A Q E EE N
Sbjct: 1042 DVISIWEK-KLNQQAEELQEIHE------IQLQEKEQEVAELKQKILLFGCEKEEMNK-- 1092
Query: 260 QADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKA 319
+I ++ E G KQ+ L +L+ K+K VN A + +LKA
Sbjct: 1093 --EITWLKEEGV----KQDTTLNELQEQLKQK------SAHVNS------LAQDETKLKA 1134
Query: 320 QQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRET 379
K E+D + E T + ++ +L L + V + + ++ +EE
Sbjct: 1135 HLEKLEVDLNKSLKENTF--LQEQLVELKMLAEEDKRKVSELTSKLKTTDEEF------- 1185
Query: 380 KSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDF 439
+S K+ +K LED L +K+ S E A+ KKT E AK
Sbjct: 1186 QSLKSSHEKSNKSLED-----KSLEFKKLSEE----LAIQLDICCKKT---EALLEAKTN 1233
Query: 440 SAISLACTKLTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIY 499
I+++ +K N I + + + +K + + T + + L+ +
Sbjct: 1234 ELINISSSK-----------TNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLT 1282
Query: 500 KEAYRIGTLFHLTKHKTDEMEDKI----AEVRRKFKGREEFLKKLTQGEVAAG------M 549
+E + F H+ +E E++I A++ +E K+ + AA
Sbjct: 1283 EEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCIT 1342
Query: 550 VLQKKLYSIYEVQALERKELIKNRA-ICAMS--LAELQEPL---LQLEDEAERIRSLDKE 603
L+K+L L ++EL + + I ++S L +L L + L ++ I SL K+
Sbjct: 1343 QLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQ 1402
Query: 604 HSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMI 663
+ ++DQ V + K+ K+ + AL + + + + + +S+
Sbjct: 1403 YDEEKCELLDQ-------VQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQ 1455
Query: 664 FYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEER 723
+ EL +L+ K +E D+ + +LK + + + KR FD E +D + +
Sbjct: 1456 HQNTVKELQIQLELKSKEAYEKDEQINLLKEE-LDQQNKR------FDCLKGEMEDDKSK 1508
Query: 724 IFEEDQRFRVLL---AVRQKTLQD--TQKII-ADSLEENLRLAQEYQQLQITFLKEKDNY 777
+ +++ L R L+D TQK I +SL E L+ + + ++ L +K +
Sbjct: 1509 MEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQH 1568
Query: 778 FNIYDKQLSLDTSIRD-KKQLCQLQRRMHTLWQEHFKLVVLFSQMRLANFQTDSQESIQK 836
F ++ D +++ ++++ L+ +++++ E L ++ N S+E K
Sbjct: 1569 FQELGEE--KDNRVKEAEEKILTLENQVYSMKAE---LETKKKELEHVNLSVKSKEEELK 1623
Query: 837 ILAVQEESSN 846
L + ES +
Sbjct: 1624 ALEDRLESES 1633
Score = 31.6 bits (70), Expect = 3.3
Identities = 38/168 (22%), Positives = 72/168 (42%), Gaps = 22/168 (13%)
Query: 625 VKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFY--AKINELNEELKAKEEE- 681
+K+ L + K ++L+ T S+ S DL+ S T F + ++ E+L +
Sbjct: 80 IKESLFRSSSK--ESLVRTSSRESLNRLDLD---SSTASFDPPSDMDSEAEDLVGNSDSL 134
Query: 682 -KKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFE-EDQRFRVLLAVRQ 739
K+ Q L ++ + R K T + +EKK + + + +D+ R + +R+
Sbjct: 135 NKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELRE 194
Query: 740 KTLQDTQKIIADSLEENLRLAQEYQQLQITFLKEKDNYFNIYDKQLSL 787
+ D Q L +E+ L+EKD Y ++ Q+SL
Sbjct: 195 ELQMDQQA--------KKHLQEEFD----ASLEEKDQYISVLQTQVSL 230
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 80.9 bits (198), Expect = 5e-15
Identities = 153/739 (20%), Positives = 303/739 (41%), Gaps = 100/739 (13%)
Query: 89 VNIPAPCVNKMISHIQDVESKIQEHLKRFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKP 148
VNI K+ + D+E +++ K+ E R DLK T ++ K
Sbjct: 1020 VNILTKAKTKLEQQVDDLEGSLEQE-KKLRMDLERAKRKLEG-DLKLAQESTMDMENDK- 1076
Query: 149 GEKRDEKCPELKQEMETLLSEA-------IRLIKSLETDRADAEEALKQQRSRKNMINMK 201
++ DEK + + E+ L+S+ I+L K ++ +A EE L ++ + K
Sbjct: 1077 -QQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEE-LGEEIEAERASRAK 1134
Query: 202 IDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFEKQKTELEEANAKIQA 261
+ +EL ++ EA + +++ + + +A F+K + +LEEA + +A
Sbjct: 1135 AEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAE----FQKLRRDLEEATLQHEA 1190
Query: 262 DI--------DYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLH------RKVNEELEE 307
+ D M E G +D+ Q + + K + KME DL K LE+
Sbjct: 1191 MVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEK 1250
Query: 308 ALEACENARLKAQQIKEEIDKDIYQDEKTIEA--------YKREIYQLNSLFDHYSSSVI 359
+ E+ ++ + KEE + + D A Y R++ + ++L S S
Sbjct: 1251 MCRSLED-QVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQ 1309
Query: 360 NVNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLED---LRRVYDQ-------------- 402
IEE + ++ E ETK+ H+L D LR Y++
Sbjct: 1310 ASTQQIEELKHQLEE---ETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1366
Query: 403 -----LTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKKLE 457
W+ K +E ++ + AKK L + + A++ C L + ++L+
Sbjct: 1367 ANSEVAQWRTK-YETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQ 1425
Query: 458 IDINKITVKTNES----IRKKSKYESEIKYLTIMKLKNDK---HLKNIYKEAYRIGTLFH 510
++ + + S K + K L+ K K ++ L+ KE+ + T
Sbjct: 1426 NEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELF 1485
Query: 511 LTKHKTDEMEDKIAEVRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELI 570
K+ +E D++ +RR+ K ++ + LT+ ++A G +L I + E+ E+
Sbjct: 1486 KVKNVYEESLDQLETLRRENKNLQQEISDLTE-QIAEGGKQIHELEKIKKQVEQEKCEIQ 1544
Query: 571 KNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLR 630
SL + +L+++ E +++S + IDQ ++R +V + +
Sbjct: 1545 AALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQ---LKRNHTRVVETM- 1600
Query: 631 KKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLE 690
+ TLDA I + + + K +E ++ I +LN + E +++ T
Sbjct: 1601 ---QSTLDAEIRSRNDALRVKKKMEGDLNEMEI------QLNHANRLAAESLRNYRNTQG 1651
Query: 691 ILKNKFITMRFKREHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQK---TLQDTQK 747
ILK Q D ++ ++D +E++ ++R +L A ++ TL+ T++
Sbjct: 1652 ILK-----------ETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTER 1700
Query: 748 IIADSLEENLRLAQEYQQL 766
+ +E L ++ Q L
Sbjct: 1701 SRKIAEQELLDASERVQLL 1719
Score = 72.4 bits (176), Expect = 2e-12
Identities = 148/789 (18%), Positives = 315/789 (39%), Gaps = 87/789 (11%)
Query: 133 LKEDWSVTTPVKEV-KPGEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQQ 191
+K + +KEV + E+ +E EL + L E L K ++ + K++
Sbjct: 912 IKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEK 971
Query: 192 RSRKNMINMKIDSWS-----VWKLQELPLAVQKEHEAYLSDVIELQWHLEDKANQLQHFE 246
+ +N + + + + KL + A+Q+ H+ L D LQ EDK N L
Sbjct: 972 HATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDD---LQAE-EDKVNILT--- 1024
Query: 247 KQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELE 306
K KT+LE+ ++ ++ + L+ + + DLK + M++ + ++++E+LE
Sbjct: 1025 KAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLE 1084
Query: 307 EALEACENARLK---AQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNT 363
+ N K Q ++ ++ K I + + IE EI + +++
Sbjct: 1085 KKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSR 1144
Query: 364 NIEEKEEEVTEA-------IRETKSSKNELHSLSKMLEDLRRVYDQLTWK-QKSHENQYL 415
+EE E + EA + K + E L + LE+ ++ + +K H +
Sbjct: 1145 ELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMA 1204
Query: 416 ---EAVNDFYAAKKTWD-------IELSDVAKDFSAISLACTKLTEDNKKLEIDINKITV 465
E +++ K+ + +E D++ + AIS A L + + LE ++++
Sbjct: 1205 ELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKT 1264
Query: 466 KTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYRIGTLFHLTKHKTDEMEDKIAE 525
K E R + ++ L + + ++ + + ++ + L + T ++E+ +
Sbjct: 1265 KEEEQQRLINDLTAQRARL---QTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQ 1321
Query: 526 VRRKFKGREEFLKKLTQGEVAAGMVLQKKLYSIYEVQALERKELIKNRAICAMSLAELQE 585
+ + K + L + L+++ E +A ++ L K + A + +
Sbjct: 1322 LEEETKAKNALAHALQSSRHDCDL-LREQYEEEQEGKAELQRALSKANSEVAQWRTKYET 1380
Query: 586 PLLQLEDEAERIRSLDKEHSVMLNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETES 645
+Q +E E + K+ + L + + + K ++K ++ + D +++ E
Sbjct: 1381 DAIQRTEELEEAK---KKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER 1437
Query: 646 KR---SAIFKDLEATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFK 702
+A+ K + K E EL+A ++E +S L +KN + +
Sbjct: 1438 SNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQ 1497
Query: 703 REHAQTVFDHYMQEKKDCEERIFEEDQRFRVLLAVRQKTLQDTQKIIADSLEEN------ 756
E + + QE D E+I E ++ L ++++ Q+ +I A +LEE
Sbjct: 1498 LETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQA-ALEEAEASLEH 1556
Query: 757 -----LRLAQEYQQLQITF---LKEKDNYFN---------IYDKQLSLDTSIRDKKQLCQ 799
LR+ E Q++ + EKD + + Q +LD IR + +
Sbjct: 1557 EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALR 1616
Query: 800 LQRRMH------TLWQEHFKLVVLFSQMRLANFQ-------------TDSQESIQKILAV 840
++++M + H + S N Q QE +++ LA+
Sbjct: 1617 VKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAI 1676
Query: 841 QEESSNLMQ 849
E +NL+Q
Sbjct: 1677 VERRANLLQ 1685
Score = 64.3 bits (155), Expect = 5e-10
Identities = 138/706 (19%), Positives = 280/706 (39%), Gaps = 124/706 (17%)
Query: 116 RFETSFEEWSRTSSTKDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIK 175
R +T E+SR KD ++ + + K + ++ ELK ++E L
Sbjct: 1282 RLQTEAGEYSRQLDEKD-----ALVSQLSRSK--QASTQQIEELKHQLEEETKAKNALAH 1334
Query: 176 SLETDRADAEEALKQQRSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHL 235
+L++ R D + L++Q + QE +Q+ S+V QW
Sbjct: 1335 ALQSSRHDCD-LLREQYEEE---------------QEGKAELQRALSKANSEVA--QWRT 1376
Query: 236 EDKANQLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSK---QNQELQDLKNHYKKKM 292
+ + + +Q E ELEEA K+ + EH +++K + Q L+N + M
Sbjct: 1377 KYETDAIQRTE----ELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1432
Query: 293 EVMDLHRKVNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFD 352
++ L++ + + +Q EE ++ +K + E++++ ++++
Sbjct: 1433 LDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYE 1492
Query: 353 HYSSSVINV---NTNIEEKEEEVTEAIRETKSSKNELHSLSKMLE----DLRRVYDQLTW 405
+ + N N++++ ++TE I E +EL + K +E +++ ++
Sbjct: 1493 ESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEA 1552
Query: 406 KQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTKLTEDNKK-LEIDINKIT 464
+ E + L + K D ++++ ++ + T++ E + L+ +I
Sbjct: 1553 SLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRS-- 1610
Query: 465 VKTNESIRKKSKYESEIKYLTIM----------KLKNDKHLKNIYKEAYRIGTLFHLTK- 513
N+++R K K E ++ + I L+N ++ + I KE T HL
Sbjct: 1611 --RNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKE-----TQLHLDDA 1663
Query: 514 -HKTDEMEDKIAEVRRKFK----GREEFLKKLTQGEVAAGMVLQKKLYSIYEVQAL--ER 566
+++++++A V R+ EE L Q E + + Q+ L + VQ L +
Sbjct: 1664 LRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQN 1723
Query: 567 KELIKNRAICAMSLAELQ---EPLLQ------------LEDEAERIRSLDKEHSVM---- 607
LI + +++LQ E ++Q + D A L KE
Sbjct: 1724 TSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1783
Query: 608 ------------LNNIIDQKDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLE 655
L + +D+ + + K GK + + + + L+ +E E KR+A E
Sbjct: 1784 RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNA-----E 1838
Query: 656 ATKSKTMIFYAKINELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQ 715
A K K +EL + EE + L+ L +K Q Y +
Sbjct: 1839 AVKG-----LRKHERRVKELTYQTEEDRKNVLRLQDLVDKL----------QAKVKSYKR 1883
Query: 716 EKKDCEERIFEEDQRFRVLLAVRQKTLQDTQK--IIADSLEENLRL 759
+ ++ EE+ +FR L Q L++ ++ IA+S LR+
Sbjct: 1884 QAEEAEEQSNANLSKFRKL----QHELEEAEERADIAESQVNKLRV 1925
Score = 61.6 bits (148), Expect = 3e-09
Identities = 96/511 (18%), Positives = 206/511 (40%), Gaps = 47/511 (9%)
Query: 271 PLLDSKQNQ-ELQDLKNHYKKKMEVMDLHRKVNEELEEALEACENARLKAQ-QIKEEIDK 328
PLL S + + E+ +K ++K + + +ELEE + + Q Q++ E D
Sbjct: 841 PLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADS 900
Query: 329 DIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEEKEEEVTEAIRETKSSKNELHS 388
+E+ + K +I + + V EE+EE E + + ++E
Sbjct: 901 LADAEERCEQLIKNKI--------QLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSE 952
Query: 389 LSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKTWDIELSDVAKDFSAISLACTK 448
L K ++DL ++ ++ + EN+ + +T ++ ++K+ A+ +
Sbjct: 953 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDET----IAKLSKEKKALQETHQQ 1008
Query: 449 LTEDNKKLEIDINKITVKTNESIRKKSKYESEIKYLTIMKLKNDKHLKNIYKEAYR-IGT 507
+D + E +N +T + K+K E ++ L L+ +K L+ + A R +
Sbjct: 1009 TLDDLQAEEDKVNILT-------KAKTKLEQQVDDLE-GSLEQEKKLRMDLERAKRKLEG 1060
Query: 508 LFHLTKHKTDEMEDKIAEVRRKFKGREEFLKKL---TQGEVAAGMVLQKKLYSI------ 558
L + T +ME+ ++ K + +E + L + E A + LQKK+ +
Sbjct: 1061 DLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEE 1120
Query: 559 ----YEVQALERKELIKNRAICAMSLAELQEPLLQLEDEAERIRSLDKEHSVMLNNIIDQ 614
E + R + K R+ + L E+ E L + L+K+ +
Sbjct: 1121 LGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRD 1180
Query: 615 KDLIRRKVGKVKKKLRKKGKKTLDALIETESKRSAIFKDLEATKSKTMIFYAKINELNEE 674
+ + + LRKK ++ L E + + LE KS+ + + ++L+
Sbjct: 1181 LEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKM---ETDDLSSN 1237
Query: 675 LKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFD-------HYMQEKKDCEERIFEE 727
+A + K + ++ L+++ ++ K E Q + + E + ++ E+
Sbjct: 1238 AEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEK 1297
Query: 728 DQRFRVLLAVRQKTLQDTQKIIADSLEENLR 758
D L +Q + Q ++ + LEE +
Sbjct: 1298 DALVSQLSRSKQASTQQIEE-LKHQLEEETK 1327
Score = 44.3 bits (103), Expect = 5e-04
Identities = 60/288 (20%), Positives = 116/288 (40%), Gaps = 37/288 (12%)
Query: 131 KDLKEDWSVTTPVKEVKPGEKRDEKCPELKQEMETLLSEAIRLIKSLETDRADAEEALKQ 190
+DLKE ++ E+R +E+ L + R K E + DA E ++
Sbjct: 1668 EDLKEQLAIV---------ERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQL 1718
Query: 191 QRSRK-NMINMK---------IDSWSVWKLQELPLAVQKEHEAYLSDVIELQWHLEDKAN 240
++ ++IN K + S +QE A +K +A ++D + L+ + +
Sbjct: 1719 LHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKA-ITDAAMMAEELKKEQD 1777
Query: 241 QLQHFEKQKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRK 300
H E+ K LE+ +Q +D + KQ Q+L+ V +L +
Sbjct: 1778 TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE---------ARVRELEGE 1828
Query: 301 VNEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVIN 360
V E + EA + R +++KE YQ E+ ++ + +L L D + V +
Sbjct: 1829 VENEQKRNAEAVKGLRKHERRVKEL----TYQTEED----RKNVLRLQDLVDKLQAKVKS 1880
Query: 361 VNTNIEEKEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQK 408
EE EE+ + + + ++EL + + ++L K +
Sbjct: 1881 YKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSR 1928
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.348
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,997,949
Number of Sequences: 37866
Number of extensions: 1274844
Number of successful extensions: 10309
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 182
Number of HSP's successfully gapped in prelim test: 793
Number of HSP's that attempted gapping in prelim test: 5727
Number of HSP's gapped (non-prelim): 3021
length of query: 867
length of database: 18,247,518
effective HSP length: 111
effective length of query: 756
effective length of database: 14,044,392
effective search space: 10617560352
effective search space used: 10617560352
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.