Guide to the Human Genome
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Search of human proteins with 8923526

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|8923526 HRAS-like suppressor 2 [Homo sapiens]
         (162 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|8923526 HRAS-like suppressor 2 [Homo sapiens]                      318   1e-87
gi|189571621 HRAS-like suppressor 3 [Homo sapiens]                    223   6e-59
gi|189571618 HRAS-like suppressor 3 [Homo sapiens]                    223   6e-59
gi|149588791 retinoic acid receptor responder (tazarotene induce...   160   3e-40
gi|9966859 HRAS-like suppressor [Homo sapiens]                        143   7e-35
gi|16905367 HRAS-like suppressor family, member 5 isoform 1 [Hom...   140   6e-34
gi|226491950 HRAS-like suppressor family, member 5 isoform 2 [Ho...   140   6e-34
gi|226528146 HRAS-like suppressor family, member 5 isoform 3 [Ho...   108   3e-24
gi|46249410 lecithin retinol acyltransferase [Homo sapiens]            66   1e-11
gi|28557798 family with sequence similarity 84, member B [Homo s...    44   8e-05
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...    35   0.037
gi|21553329 family with sequence similarity 84, member A [Homo s...    31   0.53 
gi|7705320 hepatoma-derived growth factor, related protein 3 [Ho...    28   2.6  
gi|58218986 thymocyte selection pathway associated [Homo sapiens]      28   4.5  
gi|110349719 titin isoform N2-A [Homo sapiens]                         27   7.7  
gi|110349717 titin isoform novex-2 [Homo sapiens]                      27   7.7  
gi|110349713 titin isoform novex-1 [Homo sapiens]                      27   7.7  
gi|110349715 titin isoform N2-B [Homo sapiens]                         27   7.7  

>gi|8923526 HRAS-like suppressor 2 [Homo sapiens]
          Length = 162

 Score =  318 bits (816), Expect = 1e-87
 Identities = 162/162 (100%), Positives = 162/162 (100%)

Query: 1   MALARPRPRLGDLIEISRFGYAHWAIYVGDGYVVHLAPASEIAGAGAASVLSALTNKAIV 60
           MALARPRPRLGDLIEISRFGYAHWAIYVGDGYVVHLAPASEIAGAGAASVLSALTNKAIV
Sbjct: 1   MALARPRPRLGDLIEISRFGYAHWAIYVGDGYVVHLAPASEIAGAGAASVLSALTNKAIV 60

Query: 61  KKELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYSLTSDNCEHFVNHL 120
           KKELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYSLTSDNCEHFVNHL
Sbjct: 61  KKELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYSLTSDNCEHFVNHL 120

Query: 121 RYGVSRSDQVTGAVTTVGVAAGLLAAASLVGILLARSKRERQ 162
           RYGVSRSDQVTGAVTTVGVAAGLLAAASLVGILLARSKRERQ
Sbjct: 121 RYGVSRSDQVTGAVTTVGVAAGLLAAASLVGILLARSKRERQ 162


>gi|189571621 HRAS-like suppressor 3 [Homo sapiens]
          Length = 162

 Score =  223 bits (568), Expect = 6e-59
 Identities = 109/157 (69%), Positives = 130/157 (82%)

Query: 6   PRPRLGDLIEISRFGYAHWAIYVGDGYVVHLAPASEIAGAGAASVLSALTNKAIVKKELL 65
           P P+ GDLIEI R  Y HWAIYVGDGYVVHLAP SE+AGAGAASV+SALT+KAIVKKELL
Sbjct: 6   PEPKPGDLIEIFRPFYRHWAIYVGDGYVVHLAPPSEVAGAGAASVMSALTDKAIVKKELL 65

Query: 66  SVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYSLTSDNCEHFVNHLRYGVS 125
             VAG D Y+VNNKHDD+Y+PLP +KI++RAEELVGQE+ Y LTS+NCEHFVN LRYGV+
Sbjct: 66  YDVAGSDKYQVNNKHDDKYSPLPCSKIIQRAEELVGQEVLYKLTSENCEHFVNELRYGVA 125

Query: 126 RSDQVTGAVTTVGVAAGLLAAASLVGILLARSKRERQ 162
           RSDQV   +    VA   LAA SL+G++ +R+KR++Q
Sbjct: 126 RSDQVRDVIIAASVAGMGLAAMSLIGVMFSRNKRQKQ 162


>gi|189571618 HRAS-like suppressor 3 [Homo sapiens]
          Length = 162

 Score =  223 bits (568), Expect = 6e-59
 Identities = 109/157 (69%), Positives = 130/157 (82%)

Query: 6   PRPRLGDLIEISRFGYAHWAIYVGDGYVVHLAPASEIAGAGAASVLSALTNKAIVKKELL 65
           P P+ GDLIEI R  Y HWAIYVGDGYVVHLAP SE+AGAGAASV+SALT+KAIVKKELL
Sbjct: 6   PEPKPGDLIEIFRPFYRHWAIYVGDGYVVHLAPPSEVAGAGAASVMSALTDKAIVKKELL 65

Query: 66  SVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYSLTSDNCEHFVNHLRYGVS 125
             VAG D Y+VNNKHDD+Y+PLP +KI++RAEELVGQE+ Y LTS+NCEHFVN LRYGV+
Sbjct: 66  YDVAGSDKYQVNNKHDDKYSPLPCSKIIQRAEELVGQEVLYKLTSENCEHFVNELRYGVA 125

Query: 126 RSDQVTGAVTTVGVAAGLLAAASLVGILLARSKRERQ 162
           RSDQV   +    VA   LAA SL+G++ +R+KR++Q
Sbjct: 126 RSDQVRDVIIAASVAGMGLAAMSLIGVMFSRNKRQKQ 162


>gi|149588791 retinoic acid receptor responder (tazarotene induced)
           3 [Homo sapiens]
          Length = 164

 Score =  160 bits (406), Expect = 3e-40
 Identities = 81/143 (56%), Positives = 95/143 (66%)

Query: 1   MALARPRPRLGDLIEISRFGYAHWAIYVGDGYVVHLAPASEIAGAGAASVLSALTNKAIV 60
           MA     P+ GDLIEI R GY HWA+Y+GDGYV+HLAP SE  GAG++SV S L+N A V
Sbjct: 1   MASPHQEPKPGDLIEIFRLGYEHWALYIGDGYVIHLAPPSEYPGAGSSSVFSVLSNSAEV 60

Query: 61  KKELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYSLTSDNCEHFVNHL 120
           K+E L  V GG  YRVNN  D  Y P P   I+  A+E+VGQ++ YS+ S NCEHFV  L
Sbjct: 61  KRERLEDVVGGCCYRVNNSLDHEYQPRPVEVIISSAKEMVGQKMKYSIVSRNCEHFVTQL 120

Query: 121 RYGVSRSDQVTGAVTTVGVAAGL 143
           RYG SR  QV  A   VGVA  L
Sbjct: 121 RYGKSRCKQVEKAKVEVGVATAL 143


>gi|9966859 HRAS-like suppressor [Homo sapiens]
          Length = 168

 Score =  143 bits (360), Expect = 7e-35
 Identities = 69/145 (47%), Positives = 96/145 (66%), Gaps = 1/145 (0%)

Query: 8   PRLGDLIEISRFGYAHWAIYVGDGYVVHLAPASEIAGAGAASVLSALTNKAIVKKELLSV 67
           P  GDLIE+ R GY HWA+Y+GDGYV+++AP   I  A   S  S  ++KA+VK +LL  
Sbjct: 15  PCPGDLIEVFRPGYQHWALYLGDGYVINIAPVDGIP-ASFTSAKSVFSSKALVKMQLLKD 73

Query: 68  VAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYSLTSDNCEHFVNHLRYGVSRS 127
           V G D YR+NNK+D+ Y PLP  +I+KR+E ++GQE+ Y+L  +NCEHFV  LRYG   S
Sbjct: 74  VVGNDTYRINNKYDETYPPLPVEEIIKRSEFVIGQEVAYNLLVNNCEHFVTLLRYGEGVS 133

Query: 128 DQVTGAVTTVGVAAGLLAAASLVGI 152
           +Q   A++TV      +   S +G+
Sbjct: 134 EQANRAISTVEFVTAAVGVFSFLGL 158


>gi|16905367 HRAS-like suppressor family, member 5 isoform 1 [Homo
           sapiens]
          Length = 279

 Score =  140 bits (352), Expect = 6e-34
 Identities = 76/146 (52%), Positives = 95/146 (65%), Gaps = 2/146 (1%)

Query: 2   ALARPRPRLGDLIEISRFGYAHWAIYVGDGYVVHLAPASEIAGAGAASVLSALTNKAIVK 61
           A  +PRPR GDLIEI R GY HWAIYV D  VVHLAP SE    G  S+ S  +N+A+VK
Sbjct: 124 AEGKPRPRPGDLIEIFRIGYEHWAIYVEDDCVVHLAPPSEEFEVG--SITSIFSNRAVVK 181

Query: 62  KELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYSLTSDNCEHFVNHLR 121
              L  V  G +++VNNK D  Y PLP +KI++R +++V + + YSL   NCEHFVN LR
Sbjct: 182 YSRLEDVLHGCSWKVNNKLDGTYLPLPVDKIIQRTKKMVNKIVQYSLIEGNCEHFVNGLR 241

Query: 122 YGVSRSDQVTGAVTTVGVAAGLLAAA 147
           YGV RS QV  A+     AAG + +A
Sbjct: 242 YGVPRSQQVEHALMEGAKAAGAVISA 267


>gi|226491950 HRAS-like suppressor family, member 5 isoform 2 [Homo
           sapiens]
          Length = 269

 Score =  140 bits (352), Expect = 6e-34
 Identities = 76/146 (52%), Positives = 95/146 (65%), Gaps = 2/146 (1%)

Query: 2   ALARPRPRLGDLIEISRFGYAHWAIYVGDGYVVHLAPASEIAGAGAASVLSALTNKAIVK 61
           A  +PRPR GDLIEI R GY HWAIYV D  VVHLAP SE    G  S+ S  +N+A+VK
Sbjct: 114 AEGKPRPRPGDLIEIFRIGYEHWAIYVEDDCVVHLAPPSEEFEVG--SITSIFSNRAVVK 171

Query: 62  KELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYSLTSDNCEHFVNHLR 121
              L  V  G +++VNNK D  Y PLP +KI++R +++V + + YSL   NCEHFVN LR
Sbjct: 172 YSRLEDVLHGCSWKVNNKLDGTYLPLPVDKIIQRTKKMVNKIVQYSLIEGNCEHFVNGLR 231

Query: 122 YGVSRSDQVTGAVTTVGVAAGLLAAA 147
           YGV RS QV  A+     AAG + +A
Sbjct: 232 YGVPRSQQVEHALMEGAKAAGAVISA 257


>gi|226528146 HRAS-like suppressor family, member 5 isoform 3 [Homo
           sapiens]
          Length = 253

 Score =  108 bits (269), Expect = 3e-24
 Identities = 57/112 (50%), Positives = 73/112 (65%), Gaps = 2/112 (1%)

Query: 2   ALARPRPRLGDLIEISRFGYAHWAIYVGDGYVVHLAPASEIAGAGAASVLSALTNKAIVK 61
           A  +PRPR GDLIEI R GY HWAIYV D  VVHLAP SE    G  S+ S  +N+A+VK
Sbjct: 124 AEGKPRPRPGDLIEIFRIGYEHWAIYVEDDCVVHLAPPSEEFEVG--SITSIFSNRAVVK 181

Query: 62  KELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYSLTSDNC 113
              L  V  G +++VNNK D  Y PLP +KI++R +++V + + YSL   NC
Sbjct: 182 YSRLEDVLHGCSWKVNNKLDGTYLPLPVDKIIQRTKKMVNKIVQYSLIEGNC 233


>gi|46249410 lecithin retinol acyltransferase [Homo sapiens]
          Length = 230

 Score = 66.2 bits (160), Expect = 1e-11
 Identities = 48/161 (29%), Positives = 77/161 (47%), Gaps = 22/161 (13%)

Query: 11  GDLIEISRFGYAHWAIYVGDGYVVHLAPASEIA-----------GAGAASVLSALTNKAI 59
           GD++E+ R    H+ IY+GD  V H+ P   +A            +    +L  +   A 
Sbjct: 48  GDVLEVPRTHLTHYGIYLGDNRVAHMMPDILLALTDDMGRTQKVVSNKRLILGVIVKVAS 107

Query: 60  VKKELLSVVAGGDNYRVNNKHDD-RYTPLPSNKIVKRAEELVGQELPYSLTSDNCEHFVN 118
           ++ + +   A G N  VN+  +  +   L + ++ +RAE+L+G   PYSL  +NCEHFV 
Sbjct: 108 IRVDTVEDFAYGANILVNHLDESLQKKALLNEEVARRAEKLLGFT-PYSLLWNNCEHFVT 166

Query: 119 HLRYGVSRSDQVTGAVTTVGV---------AAGLLAAASLV 150
           + RYG   S Q      TV +         A+ +L  AS+V
Sbjct: 167 YCRYGTPISPQSDKFCETVKIIIRDQRSVLASAVLGLASIV 207


>gi|28557798 family with sequence similarity 84, member B [Homo
           sapiens]
          Length = 310

 Score = 43.5 bits (101), Expect = 8e-05
 Identities = 38/114 (33%), Positives = 52/114 (45%), Gaps = 22/114 (19%)

Query: 11  GDLIE-ISRFGYAHWAIYVGDGYVVHLAPASEIAGAGAASVLSALTNKAIVKKELLSVVA 69
           GDL+E +S+  Y HWA+YVG+  VVHL                   ++  V    L+  +
Sbjct: 119 GDLVEFVSQAQYPHWAVYVGNFQVVHL-------------------HRLEVINSFLTDAS 159

Query: 70  GGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYSLTSDNCEHFVNHLRYG 123
            G   RV N    RY PL S+ +V+ A   VG +    L+  N E F    RYG
Sbjct: 160 QGRRGRVVNDL-YRYKPLSSSAVVRNALAHVGAK-ERELSWRNSESFAAWCRYG 211


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
          [Homo sapiens]
          Length = 491

 Score = 34.7 bits (78), Expect = 0.037
 Identities = 19/58 (32%), Positives = 30/58 (51%), Gaps = 4/58 (6%)

Query: 5  RPRPRLGDLIEISRFG----YAHWAIYVGDGYVVHLAPASEIAGAGAASVLSALTNKA 58
          RP P LG+L+++ R G    +  +    GD + VHL P   +   G  ++  AL +KA
Sbjct: 35 RPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKA 92


>gi|21553329 family with sequence similarity 84, member A [Homo
           sapiens]
          Length = 292

 Score = 30.8 bits (68), Expect = 0.53
 Identities = 14/32 (43%), Positives = 19/32 (59%), Gaps = 4/32 (12%)

Query: 23  HWAIYVGDGYVVHLAPA----SEIAGAGAASV 50
           HWA+YVG G ++HL         +  AGAA+V
Sbjct: 143 HWAVYVGGGQIIHLHQGEIRQDSLYEAGAANV 174


>gi|7705320 hepatoma-derived growth factor, related protein 3
          [Homo sapiens]
          Length = 203

 Score = 28.5 bits (62), Expect = 2.6
 Identities = 13/25 (52%), Positives = 15/25 (60%), Gaps = 3/25 (12%)

Query: 3  LARPRPR---LGDLIEISRFGYAHW 24
          +ARPRPR    GDL+     GY HW
Sbjct: 1  MARPRPREYKAGDLVFAKMKGYPHW 25


>gi|58218986 thymocyte selection pathway associated [Homo sapiens]
          Length = 641

 Score = 27.7 bits (60), Expect = 4.5
 Identities = 12/38 (31%), Positives = 23/38 (60%)

Query: 25  AIYVGDGYVVHLAPASEIAGAGAASVLSALTNKAIVKK 62
           ++ VGD ++VH +  +E+   G   V++ L  + I+KK
Sbjct: 382 SVSVGDQFLVHQSETTEVLCEGIKKVVNVLACEKILKK 419


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 26.9 bits (58), Expect = 7.7
 Identities = 13/35 (37%), Positives = 17/35 (48%)

Query: 89    SNKIVKRAEELVGQELPYSLTSDNCEHFVNHLRYG 123
             +N +V+R +    Q  P S TS    HF  HL  G
Sbjct: 17342 TNYVVERRDVASAQWSPLSATSKKKSHFAKHLNEG 17376


>gi|110349717 titin isoform novex-2 [Homo sapiens]
          Length = 27118

 Score = 26.9 bits (58), Expect = 7.7
 Identities = 13/35 (37%), Positives = 17/35 (48%)

Query: 89    SNKIVKRAEELVGQELPYSLTSDNCEHFVNHLRYG 123
             +N +V+R +    Q  P S TS    HF  HL  G
Sbjct: 11037 TNYVVERRDVASAQWSPLSATSKKKSHFAKHLNEG 11071


>gi|110349713 titin isoform novex-1 [Homo sapiens]
          Length = 27051

 Score = 26.9 bits (58), Expect = 7.7
 Identities = 13/35 (37%), Positives = 17/35 (48%)

Query: 89    SNKIVKRAEELVGQELPYSLTSDNCEHFVNHLRYG 123
             +N +V+R +    Q  P S TS    HF  HL  G
Sbjct: 10970 TNYVVERRDVASAQWSPLSATSKKKSHFAKHLNEG 11004


>gi|110349715 titin isoform N2-B [Homo sapiens]
          Length = 26926

 Score = 26.9 bits (58), Expect = 7.7
 Identities = 13/35 (37%), Positives = 17/35 (48%)

Query: 89    SNKIVKRAEELVGQELPYSLTSDNCEHFVNHLRYG 123
             +N +V+R +    Q  P S TS    HF  HL  G
Sbjct: 10845 TNYVVERRDVASAQWSPLSATSKKKSHFAKHLNEG 10879


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,541,276
Number of Sequences: 37866
Number of extensions: 216729
Number of successful extensions: 515
Number of sequences better than 10.0: 18
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 493
Number of HSP's gapped (non-prelim): 18
length of query: 162
length of database: 18,247,518
effective HSP length: 94
effective length of query: 68
effective length of database: 14,688,114
effective search space: 998791752
effective search space used: 998791752
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 58 (26.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
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