Search of human proteins with 55743080

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
sapiens]
         (735 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi...  1541   0.0  
gi|7656861 a disintegrin and metalloprotease domain 18 prepropro...   603   e-172
gi|148664238 a disintegrin and metalloprotease domain 32 [Homo s...   578   e-165
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H...   452   e-127
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ...   349   5e-96
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ...   339   5e-93
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ...   337   2e-92
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo...   335   7e-92
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo...   335   7e-92
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo...   335   7e-92
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ...   335   7e-92
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot...   315   1e-85
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot...   315   1e-85
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot...   311   1e-84
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ...   297   2e-80
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro...   278   2e-74
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s...   265   9e-71
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ...   262   7e-70
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor...   259   5e-69
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor...   259   5e-69
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor...   259   5e-69
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor...   259   5e-69
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor...   259   5e-69
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor...   259   5e-69
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop...   257   2e-68
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot...   253   4e-67
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot...   253   4e-67
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot...   253   4e-67
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot...   253   4e-67
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote...   253   4e-67

>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
           sapiens]
          Length = 735

 Score = 1541 bits (3989), Expect = 0.0
 Identities = 735/735 (100%), Positives = 735/735 (100%)

Query: 1   MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL 60
           MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL
Sbjct: 1   MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL 60

Query: 61  MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF 120
           MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF
Sbjct: 61  MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF 120

Query: 121 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYI 180
           ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYI
Sbjct: 121 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYI 180

Query: 181 EMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATT 240
           EMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATT
Sbjct: 181 EMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATT 240

Query: 241 GEANELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPR 300
           GEANELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPR
Sbjct: 241 GEANELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPR 300

Query: 301 TISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFA 360
           TISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFA
Sbjct: 301 TISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFA 360

Query: 361 HFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCR 420
           HFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCR
Sbjct: 361 HFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCR 420

Query: 421 FKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLN 480
           FKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLN
Sbjct: 421 FKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLN 480

Query: 481 QWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNL 540
           QWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNL
Sbjct: 481 QWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNL 540

Query: 541 QCGKLICKYVGKFLLQIPRATIIYANISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKV 600
           QCGKLICKYVGKFLLQIPRATIIYANISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKV
Sbjct: 541 QCGKLICKYVGKFLLQIPRATIIYANISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKV 600

Query: 601 CRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGN 660
           CRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGN
Sbjct: 601 CRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGN 660

Query: 661 FPPVAIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTED 720
           FPPVAIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTED
Sbjct: 661 FPPVAIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTED 720

Query: 721 YSSDEQPESESEPKG 735
           YSSDEQPESESEPKG
Sbjct: 721 YSSDEQPESESEPKG 735


>gi|7656861 a disintegrin and metalloprotease domain 18
           preproprotein [Homo sapiens]
          Length = 739

 Score =  603 bits (1556), Expect = e-172
 Identities = 313/751 (41%), Positives = 442/751 (58%), Gaps = 29/751 (3%)

Query: 1   MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL 60
           M+ +L LL+ LG L+     + + + +TVP KI+S   E  E +  Y I I+G+PYT++L
Sbjct: 1   MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL 60

Query: 61  MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF 120
            +++FLP NF VY+Y+ TG +  +   F   CHYQGY   +P S V +S C+GLRG LQF
Sbjct: 61  GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF 120

Query: 121 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLY--NEKDIESRDLSFKLQSVEPQQDFAK 178
           EN+SYGIEP+ESS  FEH+IYQ+K+   +VS+   N   I  +D  +K+      ++ +K
Sbjct: 121 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQIKNLSK 180

Query: 179 ----YIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDE 234
               Y+E+++IVEK LY++MGS+   V QK+ Q+IGL N +F  F +T+ILSSLELW +E
Sbjct: 181 LLPQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNE 240

Query: 235 NKIATTGEANELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGG 294
           N+I+T+G+A+++L  FL WK  YL+LRPHD+A+LLVYR+   YVGATF G +C+ +Y  G
Sbjct: 241 NQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLVYRKHPKYVGATFPGTVCNKSYDAG 300

Query: 295 VVLHPRTISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNC 354
           + ++P  I LE  +VI+AQLL L++G+TYDDI +C C  A CIMN EA+  SG KIFSNC
Sbjct: 301 IAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQCFCLRATCIMNHEAVSASGRKIFSNC 360

Query: 355 SFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCC 414
           S  D+ +F+SK +++CL     L P  + Q VCGN  LE+ EECDCG + +C    + CC
Sbjct: 361 SMHDYRYFVSKFETKCLQKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQF--KKCC 418

Query: 415 DIATCRFKAGSNCAEGPCC-ENCLFMSKERMCRPSFE-ECDLPEYCNGSSASCPENHYVQ 472
           D  TC+ K    C  GPCC   C        CR S + ECD  EYCNG+S++C  + Y  
Sbjct: 419 DYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYAL 478

Query: 473 TGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGY 532
            G  C L    C +G C + D QC   FGK  +  P  C+  +NS  + S NCG  +S  
Sbjct: 479 NGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFKNSQP 538

Query: 533 TQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHLCIAVEFASDHAD--SQKMWIK 590
             CE  ++ CGKL C    K   +    + +Y+ I  H+C+++   S      +   ++ 
Sbjct: 539 LPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDNAYVA 598

Query: 591 DGTSCGSNKVCRNQRCVSSSYLGYDC-TTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSD 649
           DGT CG    C N+ C     +GY+C  T KC  +G+CNN  +C C   + PPDC  Q  
Sbjct: 599 DGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGKGICNNFGNCQCFPGHRPPDCKFQFG 658

Query: 650 LWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRW---PFFLFIPFFIIFCVLIAIM 706
             PGGSID GNF       +     Y E  Y++    W    F +F+PFFI+F  +I   
Sbjct: 659 S-PGGSIDDGNF-------QKSGDFYTEKGYNTHWNNWFILSFCIFLPFFIVFTTVI--- 707

Query: 707 VKVNFQRKKWRTE--DYSSDEQPESESEPKG 735
            K N   K    E  +Y+ +    SES+  G
Sbjct: 708 FKRNEISKSCNRENAEYNRNSSVVSESDDVG 738


>gi|148664238 a disintegrin and metalloprotease domain 32 [Homo
           sapiens]
          Length = 787

 Score =  578 bits (1490), Expect = e-165
 Identities = 309/750 (41%), Positives = 443/750 (59%), Gaps = 39/750 (5%)

Query: 1   MWRVLFLLSGLGGLRMDS-NFDSLPVQITVPEKIRSIIKEGIE---SQASYKIVIEGKPY 56
           M+R+  LL+GL GL      F +  +QI +PEKI++   +  E    Q SY I I+ K Y
Sbjct: 1   MFRLWLLLAGLCGLLASRPGFQNSLLQIVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLY 60

Query: 57  TVNLMQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRG 116
           TV+L Q+ FL  NF +Y Y+  G M     D Q  C+YQG IEGYP S+V +STC+GLRG
Sbjct: 61  TVHLKQRYFLADNFMIYLYN-QGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSGLRG 119

Query: 117 VLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLS---FKLQSVEPQ 173
           +LQFENVSYGIEPLES+V F+HV+Y++K++  D++++ ++ ++ + +    F  +  EP 
Sbjct: 120 ILQFENVSYGIEPLESAVEFQHVLYKLKNEDNDIAIFIDRSLKEQPMDDNIFISEKSEPA 179

Query: 174 QD--FAKYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELW 231
               F  Y+EMH++V+K LY++ GSD+ +V  KV +++GL N++F  F +TI+LSSLELW
Sbjct: 180 VPDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELW 239

Query: 232 IDENKIATTGEANELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANY 291
            DENKI+T GEA+ELL  FL WK SYL LRPHD+A+LL+Y +   Y+GA F G MC   Y
Sbjct: 240 SDENKISTVGEADELLQKFLEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGTMCITRY 299

Query: 292 AGGVVLHPRTISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIF 351
           + GV L+P+ I+LE+ AVI+ Q+L+LS+GI+YDD  KCQCS + CIMNPE +  +GVK F
Sbjct: 300 SAGVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCIMNPEVVQSNGVKTF 359

Query: 352 SNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGE 411
           S+CS   F +FIS    +CL N+P++      + VCGN +LE  E CDCGTE  C     
Sbjct: 360 SSCSLRSFQNFISNVGVKCLQNKPQMQK-KSPKPVCGNGRLEGNEICDCGTEAQCG--PA 416

Query: 412 TCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRP-SFEECDLPEYCNGSSASCPENHY 470
           +CCD  TC  K G+ C +G CC++C  +     CRP +  ECD+ E CNGSS  C  +  
Sbjct: 417 SCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDIT 476

Query: 471 VQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGIS-D 529
           +  G  C  N++IC DG C   D +C   FGK     P  CY  + S++D  GNCG   +
Sbjct: 477 LINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRN 536

Query: 530 SGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHLCIAVEFASDHADSQKMWI 589
           + Y  C   NL CG+L+C Y  +         +IYA +   +CI V++         + +
Sbjct: 537 NKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAV 596

Query: 590 KDGTSCGSNKVCRNQRCVSSSYL--GYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQ 647
           K+G+ C   +VC N+ CV S  +       + +C+  GVC+++  CHCS  Y PP+C ++
Sbjct: 597 KNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIR 656

Query: 648 SDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRW--PFFLFIPFFIIFCVLIAI 705
           S    G SI    FP   + +       +E         W   F + +P  I+       
Sbjct: 657 S---KGFSI----FPEEDMGS------IMERASGKTENTWLLGFLIALPILIV----TTA 699

Query: 706 MVKVNFQRKKWRTEDYSSDEQPESESEPKG 735
           +V    Q KKW  ++   +E P SES+ +G
Sbjct: 700 IVLARKQLKKWFAKE---EEFPSSESKSEG 726


>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
           sapiens]
          Length = 819

 Score =  452 bits (1162), Expect = e-127
 Identities = 249/702 (35%), Positives = 380/702 (54%), Gaps = 48/702 (6%)

Query: 44  QASYKIVIEGKPYTVNLMQ-KNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYP 102
           Q SY I  EGK + ++L + K+ LP +F VY+Y+  G +     + QN CHY+GY+EG  
Sbjct: 65  QVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVH 124

Query: 103 KSVVMVSTCTGLRGVLQFENVSYGIEPLESSVGFEHVIYQVKH----------KKADVSL 152
            S + +S C GLRG+L  EN SYGIEPL++S  FEH+IY++               D+  
Sbjct: 125 NSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEK 184

Query: 153 YNEKDIESRDLSF-----KLQSVEPQQDFAKYIEMHVIVEKQLYNHMGSDTTVVAQKVFQ 207
              KD E    S      + ++V PQ    +Y+E+ ++V+K+ Y+ MG + T V +++  
Sbjct: 185 ETAKDEEEEPPSMTQLLRRRRAVLPQ---TRYVELFIVVDKERYDMMGRNQTAVREEMIL 241

Query: 208 LIGLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLRP-HDVA 266
           L    +++++  NI I+L  LE+W + N I   G A ++L  F++W+  +L+ R  HD A
Sbjct: 242 LANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSA 301

Query: 267 FLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDI 326
            L++ +      G  F G +C  ++AGG+ +  + I++E+ A I+A  L  ++G+ +DD 
Sbjct: 302 QLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQ-ITVETFASIVAHELGHNLGMNHDDG 360

Query: 327 NKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAV 386
             C C    CIMN  A   SG + FS+CS EDF      +   CL N P+ D  +   + 
Sbjct: 361 RDCSCGAKSCIMNSGA---SGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPS- 416

Query: 387 CGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCR 446
           CGN  ++AGEECDCGT ++C L  + CC+ +TC+ K+ + CA G CC++C F+    +CR
Sbjct: 417 CGNKLVDAGEECDCGTPKECEL--DPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCR 474

Query: 447 PSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEF 506
               ECD+PEYCNGSS  C  + ++Q G+PC  N+  C +G+C   D QC   FG + + 
Sbjct: 475 GKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKA 534

Query: 507 GPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYAN 566
            P +C+  +NSK D  GNCG S + Y +C   N  CGKL C+ V +  +      II   
Sbjct: 535 APKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTP 594

Query: 567 ISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTD-KCNDRG 625
             G  C  V+F           + +GT CG+ K+CRN +CV +S L YDC    KC+  G
Sbjct: 595 SRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHG 654

Query: 626 VCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPM 685
           VCN+ K+CHC   + PP+C  +     GGS+DSG           P    +        +
Sbjct: 655 VCNSNKNCHCENGWAPPNCETKG---YGGSVDSG-----------PTYNEMNTALRDGLL 700

Query: 686 RWPFFLFIPFFIIFCVLIAIMVKVNFQR---KKWRTEDYSSD 724
            + FFL +P  +I C +   + +    R   +K R++ Y SD
Sbjct: 701 VF-FFLIVP--LIVCAIFIFIKRDQLWRSYFRKKRSQTYESD 739


>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
           sapiens]
          Length = 722

 Score =  349 bits (896), Expect = 5e-96
 Identities = 215/679 (31%), Positives = 345/679 (50%), Gaps = 41/679 (6%)

Query: 1   MWRVLFL-LSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQA----SYKIVIEGKP 55
           +W  +FL +SG        +F S   ++ +P K+   I  G  ++A    SY +   G+ 
Sbjct: 17  LWLGVFLSISGYCQAGPSQHFTS--PEVVIPLKV---ISRGRSAKAPGWLSYSLRFGGQK 71

Query: 56  YTVNLMQKNFL-PHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTG- 113
           + V++  K  L   +  V++Y+    +        + C+Y GY+EG P+S+V+ S C G 
Sbjct: 72  HVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPESLVVFSACFGG 131

Query: 114 LRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYN----EKDIESRDLSFKL-- 167
            RGVL+   ++Y IEP+  S  FEH++Y+V   +           EK++  + L F+   
Sbjct: 132 FRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQLEFEEAE 191

Query: 168 -QSVEPQQ-----DFAKYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNI 221
             ++EP+        A ++E+ V+V    + +  S+ + V + VF ++ + ++++     
Sbjct: 192 NSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYQQLGT 251

Query: 222 TIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGAT 281
            IIL  +E+W   N    T    ++L+ F +WK   L    HD A + +     + +G  
Sbjct: 252 YIILIGIEIWNQGNVFPMTS-IEQVLNDFSQWKQISLSQLQHDAAHMFIKNSLISILGLA 310

Query: 282 FQGKMCDANYAGGVV-LHPRTISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNP 340
           +   +C      GV      T SL   A  +A  L  ++G+ +D+   C C    CIMN 
Sbjct: 311 YVAGICRPPIDCGVDNFQGDTWSL--FANTVAHELGHTLGMQHDE-EFCFCGERGCIMNT 367

Query: 341 EAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDC 400
             +     + F+NCS+ DF      Q S CLHN PRL   F  +  CGN  +E  E+CDC
Sbjct: 368 FRVP---AEKFTNCSYADFMKTTLNQGS-CLHNPPRLGEIFMLKR-CGNGVVEREEQCDC 422

Query: 401 GTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNG 460
           G+ Q C    + CC +  C  + G+ CA G CC++C FM    +CR    ECDLPE+CNG
Sbjct: 423 GSVQQCEQ--DACC-LLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNG 479

Query: 461 SSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTD 520
           +S  CPE+ YVQ G PC  + + C    C + D+ C + FGK+ +     CY  +NS+ +
Sbjct: 480 TSHQCPEDRYVQDGIPCSDSAY-CYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGN 538

Query: 521 VSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHLCIAVEFASD 580
             G+CGI+ + Y +C   ++ CG++ C+ V    L     T+ + +I+G  C  +++   
Sbjct: 539 RFGHCGINGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLR 598

Query: 581 HADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYL 640
              S    +KDGT CG  K+C +++CVS S L + C  + CN +G+CNNK HCHC   + 
Sbjct: 599 MNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWS 658

Query: 641 PPDCSVQSDLWPGGSIDSG 659
           PP C  +     GGSIDSG
Sbjct: 659 PPYCQHRG---YGGSIDSG 674


>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
           sapiens]
          Length = 790

 Score =  339 bits (870), Expect = 5e-93
 Identities = 238/696 (34%), Positives = 353/696 (50%), Gaps = 72/696 (10%)

Query: 17  DSNFDSLPVQITVPEKI--RSIIKEGIESQASYKIVIEGKPYTVNLMQKNFL-PHNFRVY 73
           +  FDS   ++T+PEK+  R  + +G+ S  SY + ++GK + ++L  K  L P + RV+
Sbjct: 35  EGEFDSY--EVTIPEKLSFRGEV-QGVVSPVSYLLQLKGKKHVLHLWPKRLLLPRHLRVF 91

Query: 74  SYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTG-LRGVLQFENVSYGIEPLES 132
           S++  G +          C+Y G ++    S   +STC G LRGV   +   Y IEPL++
Sbjct: 92  SFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDAKHYQIEPLKA 151

Query: 133 SVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFA------KYIEMHVIV 186
           S  FEHV+Y +K ++    +    D E        ++    +DF       KY+E+ ++ 
Sbjct: 152 SPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMAPYENKARLRDFPGSYKHPKYLELILLF 211

Query: 187 EKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATT-GEANE 245
           ++  Y  + ++ + V      L G+ +  F    + I L +LE+W D NKI     E  E
Sbjct: 212 DQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAE 271

Query: 246 LLHTFLRWKTSYLVLR-PHDVAFLLVYREKSNYVGATFQGKMCDANYAGGV-------VL 297
           +L  F+ +K S L  R   D A L + R+ ++ +  +F GK+C   YAG V       +L
Sbjct: 272 VLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSF-GKVCSLEYAGSVSTLLDTNIL 330

Query: 298 HPRTISLESLAVILAQLLSLSMGITYDDINKCQCSGAV-CIMNPEAIHFSGVKIFSNCSF 356
            P T S        A  L  ++G+++D+   CQC G + CIM       SG   FSNCS+
Sbjct: 331 APATWS--------AHELGHAVGMSHDE-QYCQCRGRLNCIMG------SGRTGFSNCSY 375

Query: 357 EDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDI 416
             F   IS   + CL+N P L    K+   CGN  +E  EECDCG+ ++C    + CC  
Sbjct: 376 ISFFKHISSGAT-CLNNIPGLGYVLKR---CGNKIVEDNEECDCGSTEECQK--DRCCQ- 428

Query: 417 ATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHP 476
           + C+ + G+NC+ G CC +C F     +CR    ECDL EYC+G+S+SCP + Y Q G P
Sbjct: 429 SNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTP 488

Query: 477 CGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISD-SGYTQC 535
           C   +  C    C S   QC   FG +    PSECY  +N   D  GNC I+    + +C
Sbjct: 489 CKY-EGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKC 547

Query: 536 EADNLQCGKLICKYVGKFLLQIPRATIIYANISGHL------CIAVEFASDHADSQKM-- 587
           E+ N  CG+L C  V + +  +P  T I   IS HL      C    +   H   + M  
Sbjct: 548 ESANSICGRLQCINV-ETIPDLPEHTTI---ISTHLQAENLMCWGTGY---HLSMKPMGI 600

Query: 588 ----WIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPD 643
                I DGTSCG  +VC  + CV+SS L +DC  +KCN RGVCNN+K+CHC   + PP 
Sbjct: 601 PDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWAPPF 660

Query: 644 CSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENI 679
           C    ++  GGSIDSG  PP  +   +P   ++ +I
Sbjct: 661 C---EEVGYGGSIDSG--PPGLLRGAIPSSIWVVSI 691


>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
           sapiens]
          Length = 776

 Score =  337 bits (864), Expect = 2e-92
 Identities = 206/681 (30%), Positives = 335/681 (49%), Gaps = 38/681 (5%)

Query: 1   MWRVLFL-LSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQA----SYKIVIEGKP 55
           +W  +FL +SG    R    F S   ++ +P K+   I  G  ++A    SY +   G+ 
Sbjct: 67  LWFGMFLSISGHSQARPSQYFTS--PEVVIPLKV---ISRGRGAKAPGWLSYSLRFGGQR 121

Query: 56  YTVNL-MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTG- 113
           Y V++ + K     +  V++Y+    +       Q+ C+Y GY+EG P+S+V +STC+G 
Sbjct: 122 YIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSGG 181

Query: 114 LRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADV-----SLYNEKDIESRDLSFKLQ 168
             G+LQ  ++ Y I+P+  S  FEH++Y++             L  EK     +L     
Sbjct: 182 FLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLSYN 241

Query: 169 SVEPQQDFA------KYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNIT 222
               Q  F       +++E+ V+V+   Y    S+ T V  +VF ++ + ++ +    + 
Sbjct: 242 FTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLEVD 301

Query: 223 IILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLR-PHDVAFLLVYREKSNYVGAT 281
           +IL+ +++W   N + T+G+ + +L  F  WK   L  R  HDVA L +   +   +G  
Sbjct: 302 VILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQGMKLGVA 361

Query: 282 FQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPE 341
           +   +C   +  GV +      L   A+ L   L  ++G+ +D    C C    CIM+  
Sbjct: 362 YVKGICQNPFNTGVDVFEDN-RLVVFAITLGHELGHNLGMQHDT-QWCVCELQWCIMHA- 418

Query: 342 AIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCG 401
             +      FSNCS+  +    +     C+   P     F+ +  CGN  +E GEECDCG
Sbjct: 419 --YRKVTTKFSNCSYAQYWDS-TISSGLCIQPPPYPGNIFRLK-YCGNLVVEEGEECDCG 474

Query: 402 TEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGS 461
           T + CA   + CC +  C    G+ CA G CC++C F+    +CR    ECDLPE+CNG+
Sbjct: 475 TIRQCAK--DPCC-LLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGT 531

Query: 462 SASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDV 521
           S  CP++ YVQ G  C +N + C +  C + D QC + FG++       CY  +N++ + 
Sbjct: 532 SHQCPDDVYVQDGISCNVNAF-CYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNR 590

Query: 522 SGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHLCIAVEFASDH 581
            G+CGI  + Y +C   ++ CG++ C+ VG     I  +T+   +++   C   ++    
Sbjct: 591 FGHCGIVGTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLGM 650

Query: 582 ADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLP 641
           A      +KDGT CG  K+C  ++C S  +L   C    CN RG+CNNK+HCHC+  + P
Sbjct: 651 AIPDIGEVKDGTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAP 710

Query: 642 PDCSVQSDLWPGGSIDSGNFP 662
           P C    D   GGS DSG  P
Sbjct: 711 PYC---KDKGYGGSADSGPPP 728


>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  335 bits (860), Expect = 7e-92
 Identities = 204/708 (28%), Positives = 363/708 (51%), Gaps = 55/708 (7%)

Query: 46  SYKIVIEGKPYTVNLMQKNFL-PHNFRVYSYSGTGIMKPLDQDF-QNFCHYQGYIEGYPK 103
           SY +   G+ + +++  K  L   +  V++Y+  G +   DQ F QN C+Y GY+EG P+
Sbjct: 53  SYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILE-DQPFVQNNCYYHGYVEGDPE 111

Query: 104 SVVMVSTCTG-LRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRD 162
           S+V +STC G  +G+LQ  + +Y I+PL  S  FEH++Y++  ++   S      +++ +
Sbjct: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQN-E 170

Query: 163 LSFKLQ------SVEPQQDFA------KYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIG 210
           ++ +++      S + Q  +       + +E+ V+++  LY     + + + + ++ ++ 
Sbjct: 171 ITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVN 230

Query: 211 LTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLR-PHDVAFLL 269
           + ++I     + ++L  LE+W ++N I    +  + +H + +WK+  +  R  HD + L 
Sbjct: 231 IVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRMQHDTSHLF 289

Query: 270 VYREKSNYVG-ATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDINK 328
                    G   F+G MC  + +  +V      +L + ++ +A  L  ++G+ +D+ + 
Sbjct: 290 TTLGLRGLSGIGAFRG-MCTPHRSCAIVTFMNK-TLGTFSIAVAHHLGHNLGMNHDE-DT 346

Query: 329 CQCSGAVCIM---NPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQA 385
           C+CS   CIM   NP       +  FSNCS+ DF  + + ++++CL         F  + 
Sbjct: 347 CRCSQPRCIMHEGNPP------ITKFSNCSYGDFWEY-TVERTKCLLETVHTKDIFNVKR 399

Query: 386 VCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMC 445
            CGN  +E GEECDCG  + CA   + CC ++ C    GS CA G CC++C F+   ++C
Sbjct: 400 -CGNGVVEEGEECDCGPLKHCAK--DPCC-LSNCTLTDGSTCAFGLCCKDCKFLPSGKVC 455

Query: 446 RPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVE 505
           R    ECDLPE+CNG+S  CP++ YV+ G PC   +  C +  C   ++QC   FG    
Sbjct: 456 RKEVNECDLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGAN 514

Query: 506 FGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYA 565
                CY  LN+  D  G+CGI ++ Y +C   ++QCG++ C+ V +        T+ +A
Sbjct: 515 TASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWA 574

Query: 566 NISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRG 625
             +  +C + ++           +KDGT CG + +C ++ CV  + L  +C+   CN RG
Sbjct: 575 RFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRG 634

Query: 626 VCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPM 685
           +CNNK HCHC+  + PP+C ++     GGS+DSG  PP   P R  ++++          
Sbjct: 635 ICNNKHHCHCNYLWDPPNCLIKG---YGGSVDSG--PP---PKRKKKKKFCYLC------ 680

Query: 686 RWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEP 733
                L I  FI+ C L  +  K    +K+   +  S+ E+ + +  P
Sbjct: 681 ---ILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEKIQRRP 725


>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  335 bits (860), Expect = 7e-92
 Identities = 204/708 (28%), Positives = 363/708 (51%), Gaps = 55/708 (7%)

Query: 46  SYKIVIEGKPYTVNLMQKNFL-PHNFRVYSYSGTGIMKPLDQDF-QNFCHYQGYIEGYPK 103
           SY +   G+ + +++  K  L   +  V++Y+  G +   DQ F QN C+Y GY+EG P+
Sbjct: 53  SYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILE-DQPFVQNNCYYHGYVEGDPE 111

Query: 104 SVVMVSTCTG-LRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRD 162
           S+V +STC G  +G+LQ  + +Y I+PL  S  FEH++Y++  ++   S      +++ +
Sbjct: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQN-E 170

Query: 163 LSFKLQ------SVEPQQDFA------KYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIG 210
           ++ +++      S + Q  +       + +E+ V+++  LY     + + + + ++ ++ 
Sbjct: 171 ITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVN 230

Query: 211 LTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLR-PHDVAFLL 269
           + ++I     + ++L  LE+W ++N I    +  + +H + +WK+  +  R  HD + L 
Sbjct: 231 IVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRMQHDTSHLF 289

Query: 270 VYREKSNYVG-ATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDINK 328
                    G   F+G MC  + +  +V      +L + ++ +A  L  ++G+ +D+ + 
Sbjct: 290 TTLGLRGLSGIGAFRG-MCTPHRSCAIVTFMNK-TLGTFSIAVAHHLGHNLGMNHDE-DT 346

Query: 329 CQCSGAVCIM---NPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQA 385
           C+CS   CIM   NP       +  FSNCS+ DF  + + ++++CL         F  + 
Sbjct: 347 CRCSQPRCIMHEGNPP------ITKFSNCSYGDFWEY-TVERTKCLLETVHTKDIFNVKR 399

Query: 386 VCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMC 445
            CGN  +E GEECDCG  + CA   + CC ++ C    GS CA G CC++C F+   ++C
Sbjct: 400 -CGNGVVEEGEECDCGPLKHCAK--DPCC-LSNCTLTDGSTCAFGLCCKDCKFLPSGKVC 455

Query: 446 RPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVE 505
           R    ECDLPE+CNG+S  CP++ YV+ G PC   +  C +  C   ++QC   FG    
Sbjct: 456 RKEVNECDLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGAN 514

Query: 506 FGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYA 565
                CY  LN+  D  G+CGI ++ Y +C   ++QCG++ C+ V +        T+ +A
Sbjct: 515 TASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWA 574

Query: 566 NISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRG 625
             +  +C + ++           +KDGT CG + +C ++ CV  + L  +C+   CN RG
Sbjct: 575 RFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRG 634

Query: 626 VCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPM 685
           +CNNK HCHC+  + PP+C ++     GGS+DSG  PP   P R  ++++          
Sbjct: 635 ICNNKHHCHCNYLWDPPNCLIKG---YGGSVDSG--PP---PKRKKKKKFCYLC------ 680

Query: 686 RWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEP 733
                L I  FI+ C L  +  K    +K+   +  S+ E+ + +  P
Sbjct: 681 ---ILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEKIQRRP 725


>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  335 bits (860), Expect = 7e-92
 Identities = 204/708 (28%), Positives = 363/708 (51%), Gaps = 55/708 (7%)

Query: 46  SYKIVIEGKPYTVNLMQKNFL-PHNFRVYSYSGTGIMKPLDQDF-QNFCHYQGYIEGYPK 103
           SY +   G+ + +++  K  L   +  V++Y+  G +   DQ F QN C+Y GY+EG P+
Sbjct: 53  SYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILE-DQPFVQNNCYYHGYVEGDPE 111

Query: 104 SVVMVSTCTG-LRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRD 162
           S+V +STC G  +G+LQ  + +Y I+PL  S  FEH++Y++  ++   S      +++ +
Sbjct: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQN-E 170

Query: 163 LSFKLQ------SVEPQQDFA------KYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIG 210
           ++ +++      S + Q  +       + +E+ V+++  LY     + + + + ++ ++ 
Sbjct: 171 ITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVN 230

Query: 211 LTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLR-PHDVAFLL 269
           + ++I     + ++L  LE+W ++N I    +  + +H + +WK+  +  R  HD + L 
Sbjct: 231 IVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRMQHDTSHLF 289

Query: 270 VYREKSNYVG-ATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDINK 328
                    G   F+G MC  + +  +V      +L + ++ +A  L  ++G+ +D+ + 
Sbjct: 290 TTLGLRGLSGIGAFRG-MCTPHRSCAIVTFMNK-TLGTFSIAVAHHLGHNLGMNHDE-DT 346

Query: 329 CQCSGAVCIM---NPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQA 385
           C+CS   CIM   NP       +  FSNCS+ DF  + + ++++CL         F  + 
Sbjct: 347 CRCSQPRCIMHEGNPP------ITKFSNCSYGDFWEY-TVERTKCLLETVHTKDIFNVKR 399

Query: 386 VCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMC 445
            CGN  +E GEECDCG  + CA   + CC ++ C    GS CA G CC++C F+   ++C
Sbjct: 400 -CGNGVVEEGEECDCGPLKHCAK--DPCC-LSNCTLTDGSTCAFGLCCKDCKFLPSGKVC 455

Query: 446 RPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVE 505
           R    ECDLPE+CNG+S  CP++ YV+ G PC   +  C +  C   ++QC   FG    
Sbjct: 456 RKEVNECDLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGAN 514

Query: 506 FGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYA 565
                CY  LN+  D  G+CGI ++ Y +C   ++QCG++ C+ V +        T+ +A
Sbjct: 515 TASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWA 574

Query: 566 NISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRG 625
             +  +C + ++           +KDGT CG + +C ++ CV  + L  +C+   CN RG
Sbjct: 575 RFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRG 634

Query: 626 VCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPM 685
           +CNNK HCHC+  + PP+C ++     GGS+DSG  PP   P R  ++++          
Sbjct: 635 ICNNKHHCHCNYLWDPPNCLIKG---YGGSVDSG--PP---PKRKKKKKFCYLC------ 680

Query: 686 RWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEP 733
                L I  FI+ C L  +  K    +K+   +  S+ E+ + +  P
Sbjct: 681 ---ILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEKIQRRP 725


>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  335 bits (860), Expect = 7e-92
 Identities = 204/708 (28%), Positives = 363/708 (51%), Gaps = 55/708 (7%)

Query: 46  SYKIVIEGKPYTVNLMQKNFL-PHNFRVYSYSGTGIMKPLDQDF-QNFCHYQGYIEGYPK 103
           SY +   G+ + +++  K  L   +  V++Y+  G +   DQ F QN C+Y GY+EG P+
Sbjct: 53  SYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILE-DQPFVQNNCYYHGYVEGDPE 111

Query: 104 SVVMVSTCTG-LRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRD 162
           S+V +STC G  +G+LQ  + +Y I+PL  S  FEH++Y++  ++   S      +++ +
Sbjct: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQN-E 170

Query: 163 LSFKLQ------SVEPQQDFA------KYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIG 210
           ++ +++      S + Q  +       + +E+ V+++  LY     + + + + ++ ++ 
Sbjct: 171 ITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVN 230

Query: 211 LTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLR-PHDVAFLL 269
           + ++I     + ++L  LE+W ++N I    +  + +H + +WK+  +  R  HD + L 
Sbjct: 231 IVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRMQHDTSHLF 289

Query: 270 VYREKSNYVG-ATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDINK 328
                    G   F+G MC  + +  +V      +L + ++ +A  L  ++G+ +D+ + 
Sbjct: 290 TTLGLRGLSGIGAFRG-MCTPHRSCAIVTFMNK-TLGTFSIAVAHHLGHNLGMNHDE-DT 346

Query: 329 CQCSGAVCIM---NPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQA 385
           C+CS   CIM   NP       +  FSNCS+ DF  + + ++++CL         F  + 
Sbjct: 347 CRCSQPRCIMHEGNPP------ITKFSNCSYGDFWEY-TVERTKCLLETVHTKDIFNVKR 399

Query: 386 VCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMC 445
            CGN  +E GEECDCG  + CA   + CC ++ C    GS CA G CC++C F+   ++C
Sbjct: 400 -CGNGVVEEGEECDCGPLKHCAK--DPCC-LSNCTLTDGSTCAFGLCCKDCKFLPSGKVC 455

Query: 446 RPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVE 505
           R    ECDLPE+CNG+S  CP++ YV+ G PC   +  C +  C   ++QC   FG    
Sbjct: 456 RKEVNECDLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGAN 514

Query: 506 FGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYA 565
                CY  LN+  D  G+CGI ++ Y +C   ++QCG++ C+ V +        T+ +A
Sbjct: 515 TASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWA 574

Query: 566 NISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRG 625
             +  +C + ++           +KDGT CG + +C ++ CV  + L  +C+   CN RG
Sbjct: 575 RFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRG 634

Query: 626 VCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPM 685
           +CNNK HCHC+  + PP+C ++     GGS+DSG  PP   P R  ++++          
Sbjct: 635 ICNNKHHCHCNYLWDPPNCLIKG---YGGSVDSG--PP---PKRKKKKKFCYLC------ 680

Query: 686 RWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEP 733
                L I  FI+ C L  +  K    +K+   +  S+ E+ + +  P
Sbjct: 681 ---ILLLIVLFILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEKIQRRP 725


>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
           [Homo sapiens]
          Length = 738

 Score =  315 bits (807), Expect = 1e-85
 Identities = 202/637 (31%), Positives = 307/637 (48%), Gaps = 41/637 (6%)

Query: 52  EGKPYTVNLMQ-KNFLPHNFRVYSYSGTGIMKPLDQDFQ---NFCHYQGYIEGYPKSVVM 107
           E K   +NL + +  +  +F    Y   G    L +++      C+Y G++ GY  S V 
Sbjct: 75  ESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVS 134

Query: 108 VSTCTGLRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKL 167
           +STC+GLRG++ FEN SY +EP++S+     +    K K    S  +  +  + +L+ K 
Sbjct: 135 LSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHHN--TPNLAAKN 192

Query: 168 QSVEPQQDFA-----------KYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIF 216
               P Q +A           KY+E+ ++ + + +   G D   V Q++ ++    +  +
Sbjct: 193 VFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFY 252

Query: 217 VSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLRP-HDVAFLL--VYRE 273
              NI I+L  +E+W D +K + + +    LH FL W+   L+ R  HD A L+  VY +
Sbjct: 253 RPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQ 312

Query: 274 KSNYVGATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDINK-CQCS 332
            +  +G      MC A+ +GG+V+      L + AV LA  L  + G+ +D +++ C C 
Sbjct: 313 GTT-IGMAPIMSMCTADQSGGIVMDHSDNPLGA-AVTLAHELGHNFGMNHDTLDRGCSCQ 370

Query: 333 GAV----CIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCG 388
            AV    CIMN     +    +FS+CS +D    + K    CL N P +   F  Q  CG
Sbjct: 371 MAVEKGGCIMNAST-GYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQK-CG 428

Query: 389 NAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPS 448
           N  +E GEECDCG  ++C      CC+  TC  K  + CA G CCE+C        CR S
Sbjct: 429 NRFVEEGEECDCGEPEECM---NRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDS 485

Query: 449 FEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGP 508
              CDLPE+C G+S  CP N Y+  GH C      C +G+C + ++QC   +G   +  P
Sbjct: 486 SNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAP 545

Query: 509 SECYSHLNSKTDVSGNCG-ISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANI 567
             C+  +NS  D  GNCG +S S + +CE  + +CGK+ C+      +    A  I  NI
Sbjct: 546 GICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNI 605

Query: 568 -----SGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCN 622
                   LC                +  GT C   K+C N++C + S  G      +C+
Sbjct: 606 PLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCH 665

Query: 623 DRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSG 659
            RGVCNN+K+CHC A + PP C        GGS DSG
Sbjct: 666 GRGVCNNRKNCHCEAHWAPPFC---DKFGFGGSTDSG 699


>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
           [Homo sapiens]
          Length = 909

 Score =  315 bits (807), Expect = 1e-85
 Identities = 202/637 (31%), Positives = 307/637 (48%), Gaps = 41/637 (6%)

Query: 52  EGKPYTVNLMQ-KNFLPHNFRVYSYSGTGIMKPLDQDFQ---NFCHYQGYIEGYPKSVVM 107
           E K   +NL + +  +  +F    Y   G    L +++      C+Y G++ GY  S V 
Sbjct: 75  ESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVS 134

Query: 108 VSTCTGLRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKL 167
           +STC+GLRG++ FEN SY +EP++S+     +    K K    S  +  +  + +L+ K 
Sbjct: 135 LSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHHN--TPNLAAKN 192

Query: 168 QSVEPQQDFA-----------KYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIF 216
               P Q +A           KY+E+ ++ + + +   G D   V Q++ ++    +  +
Sbjct: 193 VFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFY 252

Query: 217 VSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLRP-HDVAFLL--VYRE 273
              NI I+L  +E+W D +K + + +    LH FL W+   L+ R  HD A L+  VY +
Sbjct: 253 RPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQ 312

Query: 274 KSNYVGATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDINK-CQCS 332
            +  +G      MC A+ +GG+V+      L + AV LA  L  + G+ +D +++ C C 
Sbjct: 313 GTT-IGMAPIMSMCTADQSGGIVMDHSDNPLGA-AVTLAHELGHNFGMNHDTLDRGCSCQ 370

Query: 333 GAV----CIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCG 388
            AV    CIMN     +    +FS+CS +D    + K    CL N P +   F  Q  CG
Sbjct: 371 MAVEKGGCIMNAST-GYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQK-CG 428

Query: 389 NAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPS 448
           N  +E GEECDCG  ++C      CC+  TC  K  + CA G CCE+C        CR S
Sbjct: 429 NRFVEEGEECDCGEPEECM---NRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDS 485

Query: 449 FEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGP 508
              CDLPE+C G+S  CP N Y+  GH C      C +G+C + ++QC   +G   +  P
Sbjct: 486 SNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAP 545

Query: 509 SECYSHLNSKTDVSGNCG-ISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANI 567
             C+  +NS  D  GNCG +S S + +CE  + +CGK+ C+      +    A  I  NI
Sbjct: 546 GICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNI 605

Query: 568 -----SGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCN 622
                   LC                +  GT C   K+C N++C + S  G      +C+
Sbjct: 606 PLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCH 665

Query: 623 DRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSG 659
            RGVCNN+K+CHC A + PP C        GGS DSG
Sbjct: 666 GRGVCNNRKNCHCEAHWAPPFC---DKFGFGGSTDSG 699


>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 775

 Score =  311 bits (797), Expect = 1e-84
 Identities = 199/647 (30%), Positives = 306/647 (47%), Gaps = 36/647 (5%)

Query: 38  KEGIESQASYKIVIEGKPYTVNLMQ-KNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQG 96
           +E  E++  YK+ I GK   + L + KN L   +    Y+ TG          + C+YQG
Sbjct: 50  QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109

Query: 97  YIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLES--SVGFEHVI--YQVKHKKADVSL 152
           +I     S   +STC GLRG     +  Y IEPL      G EH +  Y    K  D + 
Sbjct: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169

Query: 153 YNEKDIESRDL-------SFKLQSVEPQ--QDFAKYIEMHVIVEKQLYNHMGSDTTVVAQ 203
             +  + + DL       + KL  ++ +  Q+  KYIE +++++   +     +   + +
Sbjct: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229

Query: 204 KVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLRP- 262
           +VF++    N ++   N  + L  +E+W D++KI  T  A+  L  F +W+ S L  R  
Sbjct: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289

Query: 263 HDVAFLLVYREKSNY-VGATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGI 321
           HD+A L+   E +   VG  F   MC   Y+ GVV    + +L  +A  +A  +  + G+
Sbjct: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVV-QDHSDNLLRVAGTMAHEMGHNFGM 347

Query: 322 TYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFF 381
            +DD + C+C   +C+M+ +A+ F     FS+CS   +  F   + S CL N P L    
Sbjct: 348 FHDDYS-CKCPSTICVMD-KALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAP-LPTDI 404

Query: 382 KQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSK 441
               +CGN  +E GE+CDCGT ++C  I   CCD  TC+ KA   CA G CCE C F   
Sbjct: 405 ISTPICGNQLVEMGEDCDCGTSEECTNI---CCDAKTCKIKATFQCALGECCEKCQFKKA 461

Query: 442 ERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFG 501
             +CRP+ +ECDLPE CNG S +CP++ +   G PC   +  C+ G C +  +QCT+ +G
Sbjct: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521

Query: 502 KEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRAT 561
              E     CY+  N      G C   D     C+A++  CGKL C+     L    R  
Sbjct: 522 PGTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIV 580

Query: 562 IIYANISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCV--SSSYLGYDCTTD 619
                          F  +    +   + +GT CG NKVC N  CV    +Y   +C++ 
Sbjct: 581 TFLT--------CKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCSS- 631

Query: 620 KCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAI 666
           KC    VC+++  C C   ++PPDC   S ++    +    FP   I
Sbjct: 632 KCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVI 678


>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
           sapiens]
          Length = 918

 Score =  297 bits (761), Expect = 2e-80
 Identities = 189/662 (28%), Positives = 302/662 (45%), Gaps = 46/662 (6%)

Query: 35  SIIKEGIESQASYKIVIEGKPYTVNLMQKN---FLPHNFRVYSYSGTGIMKPLDQDFQNF 91
           S ++E    +A  +++ EG+   ++L +KN   F P ++    Y+ +G  +   +  ++ 
Sbjct: 55  SPVREKHPLKAELRVMAEGRELILDL-EKNEQLFAP-SYTETHYTSSGNPQTTTRKLEDH 112

Query: 92  CHYQGYIEGYPKSVVMVSTCTGLRGVLQFE-NVSYGIEPLESSVGFEHVIYQVKHKKA-- 148
           C Y G +     S V +STC G+RG++    N+SY IEPL  S G +H+IY+ +H K   
Sbjct: 113 CFYHGTVRETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKG-QHLIYRSEHLKPPP 171

Query: 149 -------------DVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHVIVEKQLYNHMG 195
                        D +L   +  + R    K + +       KY+E++++ +   +    
Sbjct: 172 GNCGFEHSKPTTRDWALQFTQQTKKRPRRMKREDLNSM----KYVELYLVADYLEFQKNR 227

Query: 196 SDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKT 255
            D      K+ ++    +  + S NI I L  LE+W   N    +      L +FL W+ 
Sbjct: 228 RDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRR 287

Query: 256 SYLVLRPHDVAFLLVYRE-KSNYVGATFQGKMCDANYAGGVVLHPRTISLESLAVILAQL 314
             L  + HD A L+         +G      MC    +GGV +     ++  +A  +A  
Sbjct: 288 KLLAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAI-GVAATMAHE 346

Query: 315 LSLSMGITYDDINKCQCSGAV--CIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLH 372
           +  + G+T+D  + C  S A   CIM     H    K+F+ C+  +   ++      CL 
Sbjct: 347 MGHNFGMTHDSADCCSASAADGGCIMAAATGH-PFPKVFNGCNRRELDRYLQSGGGMCLS 405

Query: 373 NQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPC 432
           N P     +  +  CGN  LE GEECDCG E++C      CC+ + C  + G+ CA G C
Sbjct: 406 NMPDTRMLYGGRR-CGNGYLEDGEECDCGEEEEC---NNPCCNASNCTLRPGAECAHGSC 461

Query: 433 CENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSG 492
           C  C  ++   +CR    +CDLPE+C G S  CP N Y   G PC   Q  C +G+C++ 
Sbjct: 462 CHQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTY 521

Query: 493 DKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSG-YTQCEADNLQCGKLICKYVG 551
            +QC   +G      P  C+  +N   D  GNCG   +G + +C   + +CGK+ C+   
Sbjct: 522 QEQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSE 581

Query: 552 KFLLQ---IPRATIIYANISGHLCIAVEFASDHADSQKM----WIKDGTSCGSNKVCRNQ 604
              L+   +P  T I  N     C          +   M     +  GT CG N +C   
Sbjct: 582 ARPLESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEG 641

Query: 605 RCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPV 664
           +C ++S+   +    KCN  GVCNN ++CHC   + PP C+       GGSIDSG  PP 
Sbjct: 642 QCRNTSFFETEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGH---GGSIDSGPMPPE 698

Query: 665 AI 666
           ++
Sbjct: 699 SV 700


>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
           preproprotein [Homo sapiens]
          Length = 813

 Score =  278 bits (710), Expect = 2e-74
 Identities = 180/607 (29%), Positives = 283/607 (46%), Gaps = 33/607 (5%)

Query: 75  YSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFE-NVSYGIEPL--E 131
           Y   G    L  +  + CHYQG + G+P S V++ TC+G+ G++    N SY + P    
Sbjct: 97  YGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPR 156

Query: 132 SSVGFE-HVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQ-------QDFAKYIEMH 183
            S  F  H I++++           +D  ++     L    PQ       +   KY+E++
Sbjct: 157 GSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPG-GPQSRGRREARRTRKYLELY 215

Query: 184 VIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEA 243
           ++ +  L+     +     Q++ ++    + +  + +I + L+ LE+W + ++   T +A
Sbjct: 216 IVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDA 275

Query: 244 NELLHTFLRWKTSYLVLRPHDVAFLLVYRE-KSNYVGATFQGKMCDANYAGGVVLHPRTI 302
           N  L  FL+W+      RPHD A LL  R  +   VG      MC A  +GGV      +
Sbjct: 276 NATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSEL 335

Query: 303 SLESLAVILAQLLSLSMGITYDDINKCQCSGAV---CIMNPEAIHFSGVKIFSNCSFEDF 359
            + + A  +A  +  S+G+++D    C  + A    C+M     H    ++FS CS    
Sbjct: 336 PIGAAAT-MAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGH-PFPRVFSACSRRQL 393

Query: 360 AHFISKQKSQCLHNQPRLDPFFK-QQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIAT 418
             F  K    CL N P  DP      A+CGN  +EAGEECDCG  Q+C    + CC    
Sbjct: 394 RAFFRKGGGACLSNAP--DPGLPVPPALCGNGFVEAGEECDCGPGQECR---DLCCFAHN 448

Query: 419 CRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCG 478
           C  + G+ CA G CC  CL      +CR +  +CDLPE+C G+S+ CP + Y+  G PC 
Sbjct: 449 CSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCA 508

Query: 479 LNQWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSG-YTQCEA 537
                C DG C + ++QC   +G      P  C+  +NS  D  GNCG    G +  C  
Sbjct: 509 RGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAG 568

Query: 538 DNLQCGKLICKYVGKFLL---QIPRATIIYANISGHLCI-AVEFASDHADSQKM-WIKDG 592
            +  CGKL C+     LL    +P  + ++ +     C  A+   S   D   +  ++ G
Sbjct: 569 RDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPG 628

Query: 593 TSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWP 652
           T CG   VC+++RC  +++         C+  GVCN+  +CHC+  + PP C        
Sbjct: 629 TQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGF--- 685

Query: 653 GGSIDSG 659
           GGS+DSG
Sbjct: 686 GGSMDSG 692


>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
           sapiens]
          Length = 832

 Score =  265 bits (678), Expect = 9e-71
 Identities = 185/649 (28%), Positives = 302/649 (46%), Gaps = 70/649 (10%)

Query: 43  SQASYKIVIEGKPYTVNLMQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYP 102
           +QAS++I   G  + ++L+  N L  +  V  +   G  KP        C+Y G I G  
Sbjct: 149 AQASFQIEAFGSKFILDLILNNGLLSSDYVEIHYENG--KPQYSKGGEHCYYHGSIRGVK 206

Query: 103 KSVVMVSTCTGLRGVLQFENVSYGIEPLE-----SSVGFEHVIYQV---KHKKADVSLYN 154
            S V +STC GL G+ + +   Y IEPLE      S G  H+I +    ++ K   +L  
Sbjct: 207 DSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTLAGQYSKQMKNLTM 266

Query: 155 EKD------IESRDLSFKLQSVEPQQDF---AKYIEMHVIVEKQLYNHMGSDTTVVAQKV 205
           E+        E + L  + ++V P +      KY+E+ ++ + + Y    S         
Sbjct: 267 ERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFA 326

Query: 206 FQLIGLTNAIFVS-FNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLRPHD 264
             ++ L ++I+    N  ++L ++E W ++++I  T    ++LH F +++     ++ H 
Sbjct: 327 KSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQR---IKQHA 383

Query: 265 VAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISLE------SLAVILAQLLSLS 318
            A  L+ R        TF  K    +Y GGV    R + +       ++A +L+Q L+ +
Sbjct: 384 DAVHLISR-------VTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQN 436

Query: 319 MGITYDDIN---KCQC--SGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHN 373
           +GI ++  +   KC C  S   CIM    +  S  + FS CS  ++  F+ +    CL N
Sbjct: 437 LGIQWEPSSRKPKCDCTESWGGCIMEETGVSHS--RKFSKCSILEYRDFLQRGGGACLFN 494

Query: 374 QPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCC 433
           +P       +   CGN  +EAGEECDCG   +C  +   CC    C    G++C++GPCC
Sbjct: 495 RPTK---LFEPTECGNGYVEAGEECDCGFHVECYGL---CCK--KCSLSNGAHCSDGPCC 546

Query: 434 EN--CLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMS 491
            N  CLF  +   CR +  ECD+ EYC G S  CP N + Q G+ C  NQ  C +G C +
Sbjct: 547 NNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKT 606

Query: 492 GDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVG 551
            D QC   +G +       CY  LN++    GNCG     + QC   ++ CG L+C    
Sbjct: 607 RDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTN-- 664

Query: 552 KFLLQIPRATIIYANISG----HLCIAVEFASDHA----DSQKMWIKDGTSCGSNKVCRN 603
             L + PR   +   I      H    ++ +  H     D+   +++DGT CG + +C +
Sbjct: 665 --LTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVEDGTPCGPSMMCLD 722

Query: 604 QRCVSSSYLGY-DCTTDK----CNDRGVCNNKKHCHCSASYLPPDCSVQ 647
           ++C+    L    C  D     C+  GVC+N+  C C  ++   DCS++
Sbjct: 723 RKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIR 771


>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
           sapiens]
          Length = 754

 Score =  262 bits (670), Expect = 7e-70
 Identities = 175/622 (28%), Positives = 286/622 (45%), Gaps = 36/622 (5%)

Query: 42  ESQASYKIVIEGKPYTVNLMQ-KNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEG 100
           E +  Y+I +  K   ++L++ + FL  N+    YS  G          + C YQG I  
Sbjct: 56  EEELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVH 115

Query: 101 YPKSVVMVSTCTGLRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIES 160
              S   +STC GLRG  +  +  Y IEP++ S   EH+++     K ++ +    +   
Sbjct: 116 EYDSAASISTCNGLRGFFRINDQRYLIEPVKYSDEGEHLVF-----KYNLRVPYGANYSC 170

Query: 161 RDLSFKLQSV----EPQQDFA-------KYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLI 209
            +L+F  ++V    E ++D         KY+E+ ++ +  +Y   G     +  +++ ++
Sbjct: 171 TELNFTRKTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMV 230

Query: 210 GLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLRPH-DVAFL 268
              N I+ + NI + L  +E+W  E+KI         L  F  W+   L  R   D   L
Sbjct: 231 NFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVL 290

Query: 269 LVYREKSNYV-GATFQGKMCDANYAGGVV--LHPRTISLESLAVILAQLLSLSMGITYDD 325
           L  +   ++V G ++ G MC   Y+  ++  L P T     +A  +A  L  ++G+ +D+
Sbjct: 291 LSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDT---NIIANRMAHQLGHNLGMQHDE 347

Query: 326 INKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQA 385
              C C    C+M+ +      +K FS CS   +  ++   K  C+ N P    F   Q 
Sbjct: 348 F-PCTCPSGKCVMDSDG-SIPALK-FSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQ- 403

Query: 386 VCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMC 445
            CGN KL+ GEECDCG  Q+C      CCD  TC  K G  CAEG CCE+C       +C
Sbjct: 404 FCGNKKLDEGEECDCGPAQECT---NPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSIC 460

Query: 446 RPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVE 505
           RP+ +ECD PE C G S +CP++ +   G PC  ++  C  G C + + QC++ F  E  
Sbjct: 461 RPAKDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAI 520

Query: 506 FGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYA 565
                CY  +N+K +  G C   ++ +  CE  +++CGK+ C       L     T    
Sbjct: 521 ESHDICYK-MNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLK 579

Query: 566 NISGHLCIAVEFASDHADSQKM-WIKDGTSCGSNKVCRNQRCVSSS--YLGYDCTTDKCN 622
           +   +  +  +    + DS  +  +  GT CG   VC N  C++    Y+  +C + +CN
Sbjct: 580 DPQKNATVKCKTIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPS-QCN 638

Query: 623 DRGVCNNKKHCHCSASYLPPDC 644
           +  V  +   CHC     P  C
Sbjct: 639 ENPVDGHGLQCHCEEGQAPVAC 660


>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
           preproprotein [Homo sapiens]
          Length = 863

 Score =  259 bits (663), Expect = 5e-69
 Identities = 187/652 (28%), Positives = 292/652 (44%), Gaps = 42/652 (6%)

Query: 25  VQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNLMQ-KNFLPHNFRVYSYSGTGIMKP 83
           +Q  +P  ++ +++  +      K+ ++G  + + L+Q +  +P    +  Y   G    
Sbjct: 49  LQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVV 108

Query: 84  LDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRG-VLQFENVSYGIE---------PLESS 133
            +      C YQG + GY  S V + TC+GLRG V+     SY +E         P+ S 
Sbjct: 109 SEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISR 168

Query: 134 VGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHVIV---EKQL 190
           +   H+           S++ +K  E       ++         K +E+ ++    E Q 
Sbjct: 169 IQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQK 228

Query: 191 YNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTF 250
           Y     D   +  +  ++  L +  F   N+ + L  LE W   + +  +      L  F
Sbjct: 229 YR----DFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENF 284

Query: 251 LRWKTSYLVLR-PHDVAFLLVYREKSN-YVGATFQGKMCDANYAGGVVLHPRTISLESLA 308
           L W+ ++L+ R PHD A L+     S   VG   Q  +C  +++GGV +   T S+  +A
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHST-SILGVA 343

Query: 309 VILAQLLSLSMGITYD-DINKCQCSGAV----CIMNPEAIHFSGVKIFSNCSFEDFAHFI 363
             +A  L  S+G+ +D   N C C G      CIM        G+  FSNCS       +
Sbjct: 344 SSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLN-FSNCSRRALEKAL 402

Query: 364 SKQKSQCLHNQ-PRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFK 422
                 CL  + P L P     A CGN  +E GE+CDCG   DC    + CCD  TC+ +
Sbjct: 403 LDGMGSCLFERLPSLPPM---AAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLR 456

Query: 423 AGSNCA-EGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ 481
            G+ CA +GPCC+NC        CRP+  +CDLPE+C G S+ CP +  +  G PC   Q
Sbjct: 457 PGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQ 516

Query: 482 WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSG-YTQCEADNL 540
            +C+ G C S  +QC   +G   +     C    N++ +  G+CG + SG Y  C   + 
Sbjct: 517 AVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDA 576

Query: 541 QCGKLICKYVGKF--LLQIPRATI---IYANISGHLCIAVEFASDHADSQKMWIKDGTSC 595
            CG+L C+  G+   LL   R  +   I  N +   C  V        +Q +    GT+C
Sbjct: 577 ICGQLQCQ-TGRTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTAC 635

Query: 596 GSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQ 647
           G   VC + RC     LG      KC+  GVC++ +HC+C   + PPDC+ Q
Sbjct: 636 GPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ 687


>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
           preproprotein [Homo sapiens]
          Length = 862

 Score =  259 bits (663), Expect = 5e-69
 Identities = 187/652 (28%), Positives = 292/652 (44%), Gaps = 42/652 (6%)

Query: 25  VQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNLMQ-KNFLPHNFRVYSYSGTGIMKP 83
           +Q  +P  ++ +++  +      K+ ++G  + + L+Q +  +P    +  Y   G    
Sbjct: 49  LQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVV 108

Query: 84  LDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRG-VLQFENVSYGIE---------PLESS 133
            +      C YQG + GY  S V + TC+GLRG V+     SY +E         P+ S 
Sbjct: 109 SEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISR 168

Query: 134 VGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHVIV---EKQL 190
           +   H+           S++ +K  E       ++         K +E+ ++    E Q 
Sbjct: 169 IQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQK 228

Query: 191 YNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTF 250
           Y     D   +  +  ++  L +  F   N+ + L  LE W   + +  +      L  F
Sbjct: 229 YR----DFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENF 284

Query: 251 LRWKTSYLVLR-PHDVAFLLVYREKSN-YVGATFQGKMCDANYAGGVVLHPRTISLESLA 308
           L W+ ++L+ R PHD A L+     S   VG   Q  +C  +++GGV +   T S+  +A
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHST-SILGVA 343

Query: 309 VILAQLLSLSMGITYD-DINKCQCSGAV----CIMNPEAIHFSGVKIFSNCSFEDFAHFI 363
             +A  L  S+G+ +D   N C C G      CIM        G+  FSNCS       +
Sbjct: 344 SSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLN-FSNCSRRALEKAL 402

Query: 364 SKQKSQCLHNQ-PRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFK 422
                 CL  + P L P     A CGN  +E GE+CDCG   DC    + CCD  TC+ +
Sbjct: 403 LDGMGSCLFERLPSLPPM---AAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLR 456

Query: 423 AGSNCA-EGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ 481
            G+ CA +GPCC+NC        CRP+  +CDLPE+C G S+ CP +  +  G PC   Q
Sbjct: 457 PGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQ 516

Query: 482 WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSG-YTQCEADNL 540
            +C+ G C S  +QC   +G   +     C    N++ +  G+CG + SG Y  C   + 
Sbjct: 517 AVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDA 576

Query: 541 QCGKLICKYVGKF--LLQIPRATI---IYANISGHLCIAVEFASDHADSQKMWIKDGTSC 595
            CG+L C+  G+   LL   R  +   I  N +   C  V        +Q +    GT+C
Sbjct: 577 ICGQLQCQ-TGRTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTAC 635

Query: 596 GSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQ 647
           G   VC + RC     LG      KC+  GVC++ +HC+C   + PPDC+ Q
Sbjct: 636 GPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ 687


>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
           preproprotein [Homo sapiens]
          Length = 838

 Score =  259 bits (663), Expect = 5e-69
 Identities = 187/652 (28%), Positives = 292/652 (44%), Gaps = 42/652 (6%)

Query: 25  VQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNLMQ-KNFLPHNFRVYSYSGTGIMKP 83
           +Q  +P  ++ +++  +      K+ ++G  + + L+Q +  +P    +  Y   G    
Sbjct: 49  LQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVV 108

Query: 84  LDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRG-VLQFENVSYGIE---------PLESS 133
            +      C YQG + GY  S V + TC+GLRG V+     SY +E         P+ S 
Sbjct: 109 SEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISR 168

Query: 134 VGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHVIV---EKQL 190
           +   H+           S++ +K  E       ++         K +E+ ++    E Q 
Sbjct: 169 IQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQK 228

Query: 191 YNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTF 250
           Y     D   +  +  ++  L +  F   N+ + L  LE W   + +  +      L  F
Sbjct: 229 YR----DFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENF 284

Query: 251 LRWKTSYLVLR-PHDVAFLLVYREKSN-YVGATFQGKMCDANYAGGVVLHPRTISLESLA 308
           L W+ ++L+ R PHD A L+     S   VG   Q  +C  +++GGV +   T S+  +A
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHST-SILGVA 343

Query: 309 VILAQLLSLSMGITYD-DINKCQCSGAV----CIMNPEAIHFSGVKIFSNCSFEDFAHFI 363
             +A  L  S+G+ +D   N C C G      CIM        G+  FSNCS       +
Sbjct: 344 SSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLN-FSNCSRRALEKAL 402

Query: 364 SKQKSQCLHNQ-PRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFK 422
                 CL  + P L P     A CGN  +E GE+CDCG   DC    + CCD  TC+ +
Sbjct: 403 LDGMGSCLFERLPSLPPM---AAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLR 456

Query: 423 AGSNCA-EGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ 481
            G+ CA +GPCC+NC        CRP+  +CDLPE+C G S+ CP +  +  G PC   Q
Sbjct: 457 PGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQ 516

Query: 482 WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSG-YTQCEADNL 540
            +C+ G C S  +QC   +G   +     C    N++ +  G+CG + SG Y  C   + 
Sbjct: 517 AVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDA 576

Query: 541 QCGKLICKYVGKF--LLQIPRATI---IYANISGHLCIAVEFASDHADSQKMWIKDGTSC 595
            CG+L C+  G+   LL   R  +   I  N +   C  V        +Q +    GT+C
Sbjct: 577 ICGQLQCQ-TGRTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTAC 635

Query: 596 GSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQ 647
           G   VC + RC     LG      KC+  GVC++ +HC+C   + PPDC+ Q
Sbjct: 636 GPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ 687


>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
           preproprotein [Homo sapiens]
          Length = 839

 Score =  259 bits (663), Expect = 5e-69
 Identities = 187/652 (28%), Positives = 292/652 (44%), Gaps = 42/652 (6%)

Query: 25  VQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNLMQ-KNFLPHNFRVYSYSGTGIMKP 83
           +Q  +P  ++ +++  +      K+ ++G  + + L+Q +  +P    +  Y   G    
Sbjct: 49  LQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVV 108

Query: 84  LDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRG-VLQFENVSYGIE---------PLESS 133
            +      C YQG + GY  S V + TC+GLRG V+     SY +E         P+ S 
Sbjct: 109 SEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISR 168

Query: 134 VGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHVIV---EKQL 190
           +   H+           S++ +K  E       ++         K +E+ ++    E Q 
Sbjct: 169 IQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQK 228

Query: 191 YNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTF 250
           Y     D   +  +  ++  L +  F   N+ + L  LE W   + +  +      L  F
Sbjct: 229 YR----DFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENF 284

Query: 251 LRWKTSYLVLR-PHDVAFLLVYREKSN-YVGATFQGKMCDANYAGGVVLHPRTISLESLA 308
           L W+ ++L+ R PHD A L+     S   VG   Q  +C  +++GGV +   T S+  +A
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHST-SILGVA 343

Query: 309 VILAQLLSLSMGITYD-DINKCQCSGAV----CIMNPEAIHFSGVKIFSNCSFEDFAHFI 363
             +A  L  S+G+ +D   N C C G      CIM        G+  FSNCS       +
Sbjct: 344 SSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLN-FSNCSRRALEKAL 402

Query: 364 SKQKSQCLHNQ-PRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFK 422
                 CL  + P L P     A CGN  +E GE+CDCG   DC    + CCD  TC+ +
Sbjct: 403 LDGMGSCLFERLPSLPPM---AAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLR 456

Query: 423 AGSNCA-EGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ 481
            G+ CA +GPCC+NC        CRP+  +CDLPE+C G S+ CP +  +  G PC   Q
Sbjct: 457 PGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQ 516

Query: 482 WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSG-YTQCEADNL 540
            +C+ G C S  +QC   +G   +     C    N++ +  G+CG + SG Y  C   + 
Sbjct: 517 AVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDA 576

Query: 541 QCGKLICKYVGKF--LLQIPRATI---IYANISGHLCIAVEFASDHADSQKMWIKDGTSC 595
            CG+L C+  G+   LL   R  +   I  N +   C  V        +Q +    GT+C
Sbjct: 577 ICGQLQCQ-TGRTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTAC 635

Query: 596 GSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQ 647
           G   VC + RC     LG      KC+  GVC++ +HC+C   + PPDC+ Q
Sbjct: 636 GPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ 687


>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
           preproprotein [Homo sapiens]
          Length = 772

 Score =  259 bits (663), Expect = 5e-69
 Identities = 187/652 (28%), Positives = 292/652 (44%), Gaps = 42/652 (6%)

Query: 25  VQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNLMQ-KNFLPHNFRVYSYSGTGIMKP 83
           +Q  +P  ++ +++  +      K+ ++G  + + L+Q +  +P    +  Y   G    
Sbjct: 49  LQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVV 108

Query: 84  LDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRG-VLQFENVSYGIE---------PLESS 133
            +      C YQG + GY  S V + TC+GLRG V+     SY +E         P+ S 
Sbjct: 109 SEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISR 168

Query: 134 VGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHVIV---EKQL 190
           +   H+           S++ +K  E       ++         K +E+ ++    E Q 
Sbjct: 169 IQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQK 228

Query: 191 YNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTF 250
           Y     D   +  +  ++  L +  F   N+ + L  LE W   + +  +      L  F
Sbjct: 229 YR----DFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENF 284

Query: 251 LRWKTSYLVLR-PHDVAFLLVYREKSN-YVGATFQGKMCDANYAGGVVLHPRTISLESLA 308
           L W+ ++L+ R PHD A L+     S   VG   Q  +C  +++GGV +   T S+  +A
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHST-SILGVA 343

Query: 309 VILAQLLSLSMGITYD-DINKCQCSGAV----CIMNPEAIHFSGVKIFSNCSFEDFAHFI 363
             +A  L  S+G+ +D   N C C G      CIM        G+  FSNCS       +
Sbjct: 344 SSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLN-FSNCSRRALEKAL 402

Query: 364 SKQKSQCLHNQ-PRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFK 422
                 CL  + P L P     A CGN  +E GE+CDCG   DC    + CCD  TC+ +
Sbjct: 403 LDGMGSCLFERLPSLPPM---AAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLR 456

Query: 423 AGSNCA-EGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ 481
            G+ CA +GPCC+NC        CRP+  +CDLPE+C G S+ CP +  +  G PC   Q
Sbjct: 457 PGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQ 516

Query: 482 WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSG-YTQCEADNL 540
            +C+ G C S  +QC   +G   +     C    N++ +  G+CG + SG Y  C   + 
Sbjct: 517 AVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDA 576

Query: 541 QCGKLICKYVGKF--LLQIPRATI---IYANISGHLCIAVEFASDHADSQKMWIKDGTSC 595
            CG+L C+  G+   LL   R  +   I  N +   C  V        +Q +    GT+C
Sbjct: 577 ICGQLQCQ-TGRTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTAC 635

Query: 596 GSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQ 647
           G   VC + RC     LG      KC+  GVC++ +HC+C   + PPDC+ Q
Sbjct: 636 GPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ 687


>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
           preproprotein [Homo sapiens]
          Length = 814

 Score =  259 bits (663), Expect = 5e-69
 Identities = 187/652 (28%), Positives = 292/652 (44%), Gaps = 42/652 (6%)

Query: 25  VQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNLMQ-KNFLPHNFRVYSYSGTGIMKP 83
           +Q  +P  ++ +++  +      K+ ++G  + + L+Q +  +P    +  Y   G    
Sbjct: 49  LQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVV 108

Query: 84  LDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRG-VLQFENVSYGIE---------PLESS 133
            +      C YQG + GY  S V + TC+GLRG V+     SY +E         P+ S 
Sbjct: 109 SEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISR 168

Query: 134 VGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHVIV---EKQL 190
           +   H+           S++ +K  E       ++         K +E+ ++    E Q 
Sbjct: 169 IQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQK 228

Query: 191 YNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTF 250
           Y     D   +  +  ++  L +  F   N+ + L  LE W   + +  +      L  F
Sbjct: 229 YR----DFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENF 284

Query: 251 LRWKTSYLVLR-PHDVAFLLVYREKSN-YVGATFQGKMCDANYAGGVVLHPRTISLESLA 308
           L W+ ++L+ R PHD A L+     S   VG   Q  +C  +++GGV +   T S+  +A
Sbjct: 285 LHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHST-SILGVA 343

Query: 309 VILAQLLSLSMGITYD-DINKCQCSGAV----CIMNPEAIHFSGVKIFSNCSFEDFAHFI 363
             +A  L  S+G+ +D   N C C G      CIM        G+  FSNCS       +
Sbjct: 344 SSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLN-FSNCSRRALEKAL 402

Query: 364 SKQKSQCLHNQ-PRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFK 422
                 CL  + P L P     A CGN  +E GE+CDCG   DC    + CCD  TC+ +
Sbjct: 403 LDGMGSCLFERLPSLPPM---AAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLR 456

Query: 423 AGSNCA-EGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ 481
            G+ CA +GPCC+NC        CRP+  +CDLPE+C G S+ CP +  +  G PC   Q
Sbjct: 457 PGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQ 516

Query: 482 WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSG-YTQCEADNL 540
            +C+ G C S  +QC   +G   +     C    N++ +  G+CG + SG Y  C   + 
Sbjct: 517 AVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDA 576

Query: 541 QCGKLICKYVGKF--LLQIPRATI---IYANISGHLCIAVEFASDHADSQKMWIKDGTSC 595
            CG+L C+  G+   LL   R  +   I  N +   C  V        +Q +    GT+C
Sbjct: 577 ICGQLQCQ-TGRTQPLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTAC 635

Query: 596 GSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQ 647
           G   VC + RC     LG      KC+  GVC++ +HC+C   + PPDC+ Q
Sbjct: 636 GPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ 687


>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
           preproprotein [Homo sapiens]
          Length = 787

 Score =  257 bits (657), Expect = 2e-68
 Identities = 177/607 (29%), Positives = 272/607 (44%), Gaps = 59/607 (9%)

Query: 75  YSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFE-NVSYGIEPL--E 131
           Y   G    L  +  + CHYQG + G+P S V++ TC+G+ G++    N SY + P    
Sbjct: 97  YGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPR 156

Query: 132 SSVGFE-HVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQ-------QDFAKYIEMH 183
            S  F  H I++++           +D  ++     L    PQ       +   KY+E++
Sbjct: 157 GSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPG-GPQSRGRREARRTRKYLELY 215

Query: 184 VIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEA 243
           ++ +  L+     +     Q++ ++    + +  + +I + L+ LE+W + ++   T +A
Sbjct: 216 IVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDA 275

Query: 244 NELLHTFLRWKTSYLVLRPHDVAFLLVYRE-KSNYVGATFQGKMCDANYAGGVVLHPRTI 302
           N  L  FL+W+      RPHD A LL  R  +   VG      MC A  +GGV      +
Sbjct: 276 NATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSEL 335

Query: 303 SLESLAVILAQLLSLSMGITYDDINKCQCSGAV---CIMNPEAIHFSGVKIFSNCSFEDF 359
            + + A  +A  +  S+G+++D    C  + A    C+M     H    ++FS CS    
Sbjct: 336 PIGAAAT-MAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGH-PFPRVFSACSRRQL 393

Query: 360 AHFISKQKSQCLHNQPRLDPFFK-QQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIAT 418
             F  K    CL N P  DP      A+CGN  +EAGEECDCG  Q+C    + CC    
Sbjct: 394 RAFFRKGGGACLSNAP--DPGLPVPPALCGNGFVEAGEECDCGPGQECR---DLCCFAHN 448

Query: 419 CRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCG 478
           C  + G+ CA G CC  CL      +CR +  +CDLPE+C G+S+ CP + Y+  G PC 
Sbjct: 449 CSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCA 508

Query: 479 LNQWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSG-YTQCEA 537
                C DG C + ++QC   +G      P  C+  +NS  D  GNCG    G +  C  
Sbjct: 509 RGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAG 568

Query: 538 DNLQCGKLICKYVGKFLLQIPRATIIYANISGHLCIAVEFASDHADSQKMWIKDGTSCGS 597
            +  CGKL C+  GK  L  P    + + +             H D Q++          
Sbjct: 569 RDALCGKLQCQ-GGKPSLLAPHMVPVDSTV-------------HLDGQEV---------- 604

Query: 598 NKVCRNQRCVSSSY-----LGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWP 652
              CR    + S+      LG      +C  R VCN+  +CHC+  + PP C        
Sbjct: 605 --TCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCNSNHNCHCAPGWAPPFCDKPGF--- 659

Query: 653 GGSIDSG 659
           GGS+DSG
Sbjct: 660 GGSMDSG 666


>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
           [Homo sapiens]
          Length = 906

 Score =  253 bits (646), Expect = 4e-67
 Identities = 169/597 (28%), Positives = 270/597 (45%), Gaps = 62/597 (10%)

Query: 92  CHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLESSVGFE----HVIY------ 141
           C+YQG+I G P S V +STC GL G+    N +Y IEP E+    E    H +Y      
Sbjct: 135 CYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFE 194

Query: 142 -----------QVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHVIVEKQL 190
                      QV    +   L        R L    ++VE +    KYIE+ ++ +  +
Sbjct: 195 FSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEE---TKYIELMIVNDHLM 251

Query: 191 YNHMGSDTTVVAQKVFQLIGLTNAIFVS-FNITIILSSLELWIDENKIATTGEANELLHT 249
           +                ++ + + I+       I+L ++E W  +NK A +      L  
Sbjct: 252 FKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLRE 311

Query: 250 FLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISLESLAV 309
           F++++  ++  +   V      + +S+  GA + G +C     GGV    +T   + +AV
Sbjct: 312 FMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT---DLMAV 368

Query: 310 ILAQLLSLSMGITYDDIN------KCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFI 363
            LAQ L+ ++GI  D         KC+ + + CIM     +    K F+ C+ E++  F+
Sbjct: 369 TLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLP--KKFTQCNIEEYHDFL 426

Query: 364 SKQKSQCLHNQPR--LDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRF 421
           +     CL N+P   LDP       CGN  +E GEECDCGT  +C L G  CC    C  
Sbjct: 427 NSGGGACLFNKPSKLLDP-----PECGNGFIETGEECDCGTPAECVLEGAECCK--KCTL 479

Query: 422 KAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ 481
              S C++G CC+ C F     +CR +  +CD+ E C+G+S+ C  N +   G+ C   Q
Sbjct: 480 TQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQ 539

Query: 482 WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQ 541
            IC  G C + D+QC   +G++V      CY  LN +    GNCG     + QC   ++ 
Sbjct: 540 GICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVL 599

Query: 542 CGKLICKYVGKFLLQIPRATIIYANISGHLCI----AVEFASDHA----DSQKMWIKDGT 593
           CG L+C  +G     IPR   +   I+  L +     +  +  H     D    +++DGT
Sbjct: 600 CGYLLCTNIG----NIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGT 655

Query: 594 SCGSNKVCRNQRCVSSSYLGYD-CTTDK----CNDRGVCNNKKHCHCSASYLPPDCS 645
            CG   +C   RC+  +   +  C + K    C+  GVC+N+  C C+  ++  DC+
Sbjct: 656 PCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCN 712


>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
           [Homo sapiens]
          Length = 899

 Score =  253 bits (646), Expect = 4e-67
 Identities = 169/597 (28%), Positives = 270/597 (45%), Gaps = 62/597 (10%)

Query: 92  CHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLESSVGFE----HVIY------ 141
           C+YQG+I G P S V +STC GL G+    N +Y IEP E+    E    H +Y      
Sbjct: 135 CYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFE 194

Query: 142 -----------QVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHVIVEKQL 190
                      QV    +   L        R L    ++VE +    KYIE+ ++ +  +
Sbjct: 195 FSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEE---TKYIELMIVNDHLM 251

Query: 191 YNHMGSDTTVVAQKVFQLIGLTNAIFVS-FNITIILSSLELWIDENKIATTGEANELLHT 249
           +                ++ + + I+       I+L ++E W  +NK A +      L  
Sbjct: 252 FKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLRE 311

Query: 250 FLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISLESLAV 309
           F++++  ++  +   V      + +S+  GA + G +C     GGV    +T   + +AV
Sbjct: 312 FMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT---DLMAV 368

Query: 310 ILAQLLSLSMGITYDDIN------KCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFI 363
            LAQ L+ ++GI  D         KC+ + + CIM     +    K F+ C+ E++  F+
Sbjct: 369 TLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLP--KKFTQCNIEEYHDFL 426

Query: 364 SKQKSQCLHNQPR--LDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRF 421
           +     CL N+P   LDP       CGN  +E GEECDCGT  +C L G  CC    C  
Sbjct: 427 NSGGGACLFNKPSKLLDP-----PECGNGFIETGEECDCGTPAECVLEGAECCK--KCTL 479

Query: 422 KAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ 481
              S C++G CC+ C F     +CR +  +CD+ E C+G+S+ C  N +   G+ C   Q
Sbjct: 480 TQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQ 539

Query: 482 WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQ 541
            IC  G C + D+QC   +G++V      CY  LN +    GNCG     + QC   ++ 
Sbjct: 540 GICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVL 599

Query: 542 CGKLICKYVGKFLLQIPRATIIYANISGHLCI----AVEFASDHA----DSQKMWIKDGT 593
           CG L+C  +G     IPR   +   I+  L +     +  +  H     D    +++DGT
Sbjct: 600 CGYLLCTNIG----NIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGT 655

Query: 594 SCGSNKVCRNQRCVSSSYLGYD-CTTDK----CNDRGVCNNKKHCHCSASYLPPDCS 645
            CG   +C   RC+  +   +  C + K    C+  GVC+N+  C C+  ++  DC+
Sbjct: 656 PCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCN 712


>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
           [Homo sapiens]
          Length = 823

 Score =  253 bits (646), Expect = 4e-67
 Identities = 169/597 (28%), Positives = 270/597 (45%), Gaps = 62/597 (10%)

Query: 92  CHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLESSVGFE----HVIY------ 141
           C+YQG+I G P S V +STC GL G+    N +Y IEP E+    E    H +Y      
Sbjct: 135 CYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFE 194

Query: 142 -----------QVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHVIVEKQL 190
                      QV    +   L        R L    ++VE +    KYIE+ ++ +  +
Sbjct: 195 FSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEE---TKYIELMIVNDHLM 251

Query: 191 YNHMGSDTTVVAQKVFQLIGLTNAIFVS-FNITIILSSLELWIDENKIATTGEANELLHT 249
           +                ++ + + I+       I+L ++E W  +NK A +      L  
Sbjct: 252 FKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLRE 311

Query: 250 FLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISLESLAV 309
           F++++  ++  +   V      + +S+  GA + G +C     GGV    +T   + +AV
Sbjct: 312 FMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT---DLMAV 368

Query: 310 ILAQLLSLSMGITYDDIN------KCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFI 363
            LAQ L+ ++GI  D         KC+ + + CIM     +    K F+ C+ E++  F+
Sbjct: 369 TLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLP--KKFTQCNIEEYHDFL 426

Query: 364 SKQKSQCLHNQPR--LDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRF 421
           +     CL N+P   LDP       CGN  +E GEECDCGT  +C L G  CC    C  
Sbjct: 427 NSGGGACLFNKPSKLLDP-----PECGNGFIETGEECDCGTPAECVLEGAECCK--KCTL 479

Query: 422 KAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ 481
              S C++G CC+ C F     +CR +  +CD+ E C+G+S+ C  N +   G+ C   Q
Sbjct: 480 TQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQ 539

Query: 482 WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQ 541
            IC  G C + D+QC   +G++V      CY  LN +    GNCG     + QC   ++ 
Sbjct: 540 GICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVL 599

Query: 542 CGKLICKYVGKFLLQIPRATIIYANISGHLCI----AVEFASDHA----DSQKMWIKDGT 593
           CG L+C  +G     IPR   +   I+  L +     +  +  H     D    +++DGT
Sbjct: 600 CGYLLCTNIG----NIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGT 655

Query: 594 SCGSNKVCRNQRCVSSSYLGYD-CTTDK----CNDRGVCNNKKHCHCSASYLPPDCS 645
            CG   +C   RC+  +   +  C + K    C+  GVC+N+  C C+  ++  DC+
Sbjct: 656 PCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCN 712


>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
           [Homo sapiens]
          Length = 870

 Score =  253 bits (646), Expect = 4e-67
 Identities = 169/597 (28%), Positives = 270/597 (45%), Gaps = 62/597 (10%)

Query: 92  CHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLESSVGFE----HVIY------ 141
           C+YQG+I G P S V +STC GL G+    N +Y IEP E+    E    H +Y      
Sbjct: 135 CYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFE 194

Query: 142 -----------QVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHVIVEKQL 190
                      QV    +   L        R L    ++VE +    KYIE+ ++ +  +
Sbjct: 195 FSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEE---TKYIELMIVNDHLM 251

Query: 191 YNHMGSDTTVVAQKVFQLIGLTNAIFVS-FNITIILSSLELWIDENKIATTGEANELLHT 249
           +                ++ + + I+       I+L ++E W  +NK A +      L  
Sbjct: 252 FKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLRE 311

Query: 250 FLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISLESLAV 309
           F++++  ++  +   V      + +S+  GA + G +C     GGV    +T   + +AV
Sbjct: 312 FMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT---DLMAV 368

Query: 310 ILAQLLSLSMGITYDDIN------KCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFI 363
            LAQ L+ ++GI  D         KC+ + + CIM     +    K F+ C+ E++  F+
Sbjct: 369 TLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLP--KKFTQCNIEEYHDFL 426

Query: 364 SKQKSQCLHNQPR--LDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRF 421
           +     CL N+P   LDP       CGN  +E GEECDCGT  +C L G  CC    C  
Sbjct: 427 NSGGGACLFNKPSKLLDP-----PECGNGFIETGEECDCGTPAECVLEGAECCK--KCTL 479

Query: 422 KAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ 481
              S C++G CC+ C F     +CR +  +CD+ E C+G+S+ C  N +   G+ C   Q
Sbjct: 480 TQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQ 539

Query: 482 WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQ 541
            IC  G C + D+QC   +G++V      CY  LN +    GNCG     + QC   ++ 
Sbjct: 540 GICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVL 599

Query: 542 CGKLICKYVGKFLLQIPRATIIYANISGHLCI----AVEFASDHA----DSQKMWIKDGT 593
           CG L+C  +G     IPR   +   I+  L +     +  +  H     D    +++DGT
Sbjct: 600 CGYLLCTNIG----NIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGT 655

Query: 594 SCGSNKVCRNQRCVSSSYLGYD-CTTDK----CNDRGVCNNKKHCHCSASYLPPDCS 645
            CG   +C   RC+  +   +  C + K    C+  GVC+N+  C C+  ++  DC+
Sbjct: 656 PCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCN 712


>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
           [Homo sapiens]
          Length = 859

 Score =  253 bits (646), Expect = 4e-67
 Identities = 169/597 (28%), Positives = 270/597 (45%), Gaps = 62/597 (10%)

Query: 92  CHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLESSVGFE----HVIY------ 141
           C+YQG+I G P S V +STC GL G+    N +Y IEP E+    E    H +Y      
Sbjct: 135 CYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFE 194

Query: 142 -----------QVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHVIVEKQL 190
                      QV    +   L        R L    ++VE +    KYIE+ ++ +  +
Sbjct: 195 FSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEE---TKYIELMIVNDHLM 251

Query: 191 YNHMGSDTTVVAQKVFQLIGLTNAIFVS-FNITIILSSLELWIDENKIATTGEANELLHT 249
           +                ++ + + I+       I+L ++E W  +NK A +      L  
Sbjct: 252 FKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLRE 311

Query: 250 FLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISLESLAV 309
           F++++  ++  +   V      + +S+  GA + G +C     GGV    +T   + +AV
Sbjct: 312 FMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT---DLMAV 368

Query: 310 ILAQLLSLSMGITYDDIN------KCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFI 363
            LAQ L+ ++GI  D         KC+ + + CIM     +    K F+ C+ E++  F+
Sbjct: 369 TLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLP--KKFTQCNIEEYHDFL 426

Query: 364 SKQKSQCLHNQPR--LDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRF 421
           +     CL N+P   LDP       CGN  +E GEECDCGT  +C L G  CC    C  
Sbjct: 427 NSGGGACLFNKPSKLLDP-----PECGNGFIETGEECDCGTPAECVLEGAECCK--KCTL 479

Query: 422 KAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ 481
              S C++G CC+ C F     +CR +  +CD+ E C+G+S+ C  N +   G+ C   Q
Sbjct: 480 TQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQ 539

Query: 482 WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQ 541
            IC  G C + D+QC   +G++V      CY  LN +    GNCG     + QC   ++ 
Sbjct: 540 GICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVL 599

Query: 542 CGKLICKYVGKFLLQIPRATIIYANISGHLCI----AVEFASDHA----DSQKMWIKDGT 593
           CG L+C  +G     IPR   +   I+  L +     +  +  H     D    +++DGT
Sbjct: 600 CGYLLCTNIG----NIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGT 655

Query: 594 SCGSNKVCRNQRCVSSSYLGYD-CTTDK----CNDRGVCNNKKHCHCSASYLPPDCS 645
            CG   +C   RC+  +   +  C + K    C+  GVC+N+  C C+  ++  DC+
Sbjct: 656 PCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCN 712


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.435 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,543,138
Number of Sequences: 37866
Number of extensions: 1428575
Number of successful extensions: 3805
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 102
Number of HSP's that attempted gapping in prelim test: 3158
Number of HSP's gapped (non-prelim): 453
length of query: 735
length of database: 18,247,518
effective HSP length: 110
effective length of query: 625
effective length of database: 14,082,258
effective search space: 8801411250
effective search space used: 8801411250
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.