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Search of human proteins with 4758606
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758606 integrin-linked kinase [Homo sapiens]
(452 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62420875 integrin-linked kinase [Homo sapiens] 941 0.0
gi|62420873 integrin-linked kinase [Homo sapiens] 941 0.0
gi|4758606 integrin-linked kinase [Homo sapiens] 941 0.0
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 134 2e-31
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 134 2e-31
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 114 2e-25
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 114 2e-25
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 106 5e-23
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 101 1e-21
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 101 1e-21
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 101 1e-21
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 101 1e-21
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 101 1e-21
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 98 1e-20
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom... 96 9e-20
gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens] 96 9e-20
gi|187475373 c-src tyrosine kinase [Homo sapiens] 95 1e-19
gi|4758078 c-src tyrosine kinase [Homo sapiens] 95 1e-19
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 95 1e-19
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 95 1e-19
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 94 3e-19
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 94 3e-19
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 91 2e-18
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 91 2e-18
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 91 2e-18
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 91 2e-18
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 91 2e-18
gi|33188459 B-Raf [Homo sapiens] 91 3e-18
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 90 4e-18
gi|4503787 fyn-related kinase [Homo sapiens] 89 6e-18
>gi|62420875 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 941 bits (2433), Expect = 0.0
Identities = 452/452 (100%), Positives = 452/452 (100%)
Query: 1 MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI 60
MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI
Sbjct: 1 MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI 60
Query: 61 NVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLV 120
NVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLV
Sbjct: 61 NVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLV 120
Query: 121 ANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNG 180
ANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNG
Sbjct: 121 ANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNG 180
Query: 181 TLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECP 240
TLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECP
Sbjct: 181 TLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECP 240
Query: 241 RLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALD 300
RLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALD
Sbjct: 241 RLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALD 300
Query: 301 MARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEA 360
MARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEA
Sbjct: 301 MARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEA 360
Query: 361 LQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPH 420
LQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPH
Sbjct: 361 LQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPH 420
Query: 421 VCKLMKICMNEDPAKRPKFDMIVPILEKMQDK 452
VCKLMKICMNEDPAKRPKFDMIVPILEKMQDK
Sbjct: 421 VCKLMKICMNEDPAKRPKFDMIVPILEKMQDK 452
>gi|62420873 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 941 bits (2433), Expect = 0.0
Identities = 452/452 (100%), Positives = 452/452 (100%)
Query: 1 MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI 60
MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI
Sbjct: 1 MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI 60
Query: 61 NVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLV 120
NVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLV
Sbjct: 61 NVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLV 120
Query: 121 ANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNG 180
ANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNG
Sbjct: 121 ANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNG 180
Query: 181 TLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECP 240
TLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECP
Sbjct: 181 TLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECP 240
Query: 241 RLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALD 300
RLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALD
Sbjct: 241 RLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALD 300
Query: 301 MARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEA 360
MARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEA
Sbjct: 301 MARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEA 360
Query: 361 LQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPH 420
LQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPH
Sbjct: 361 LQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPH 420
Query: 421 VCKLMKICMNEDPAKRPKFDMIVPILEKMQDK 452
VCKLMKICMNEDPAKRPKFDMIVPILEKMQDK
Sbjct: 421 VCKLMKICMNEDPAKRPKFDMIVPILEKMQDK 452
>gi|4758606 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 941 bits (2433), Expect = 0.0
Identities = 452/452 (100%), Positives = 452/452 (100%)
Query: 1 MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI 60
MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI
Sbjct: 1 MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI 60
Query: 61 NVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLV 120
NVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLV
Sbjct: 61 NVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLV 120
Query: 121 ANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNG 180
ANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNG
Sbjct: 121 ANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNG 180
Query: 181 TLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECP 240
TLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECP
Sbjct: 181 TLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECP 240
Query: 241 RLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALD 300
RLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALD
Sbjct: 241 RLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALD 300
Query: 301 MARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEA 360
MARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEA
Sbjct: 301 MARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEA 360
Query: 361 LQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPH 420
LQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPH
Sbjct: 361 LQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPH 420
Query: 421 VCKLMKICMNEDPAKRPKFDMIVPILEKMQDK 452
VCKLMKICMNEDPAKRPKFDMIVPILEKMQDK
Sbjct: 421 VCKLMKICMNEDPAKRPKFDMIVPILEKMQDK 452
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 134 bits (336), Expect = 2e-31
Identities = 123/514 (23%), Positives = 219/514 (42%), Gaps = 86/514 (16%)
Query: 14 VAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI--NVMNRGDDTPL 71
+A L + ++ D+N D+ PLH+ R G +V+ L+ + +V+N DTPL
Sbjct: 215 IAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL 274
Query: 72 HLAASHGHRDIVQKLLQ--------------------------------YKADINAVN-- 97
HLA +G ++ ++++Q + D N +N
Sbjct: 275 HLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININ 334
Query: 98 ---EHGNVPLHYACFWGQDQVAEDLVANGALVSIC-----NKYGEMPVDKA--------- 140
G+ LH AC+ G ++ + L+ NGA +++ GE
Sbjct: 335 HQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 394
Query: 141 ----------KAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPR------NGTLNK 184
K P EL + G + + + K + T+ + L
Sbjct: 395 DAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPS 454
Query: 185 HSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRD-FNEECPRLR 243
H + ++ F + G+++KGR + + +K + + ++ D F E L
Sbjct: 455 HFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILC 514
Query: 244 IFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMAR 303
+HP V+ +GAC + P+ ++T ++ GSL+++LHE + QS+ + A+D+A+
Sbjct: 515 QLNHPCVIQFVGACLNDPSQF-AIVTQYISGGSLFSLLHEQKRILDLQSKLI-IAVDVAK 572
Query: 304 GMAFLHTLEPLIPRHALNSRSVMIDEDMTARIS---------MADVKFSFQCPGRMYAPA 354
GM +LH L I LNS ++++ ED A ++ D + PG +
Sbjct: 573 GMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNL---R 629
Query: 355 WVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIP 414
W+APE + T + AD++S+A+ LWE++T E+PFA L +A +RP I
Sbjct: 630 WMAPEVFTQCTRYTIK--ADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIG 687
Query: 415 PGISPHVCKLMKICMNEDPAKRPKFDMIVPILEK 448
I + L+ N P RP+F +V LE+
Sbjct: 688 YSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEE 721
Score = 67.4 bits (163), Expect = 3e-11
Identities = 34/99 (34%), Positives = 59/99 (59%), Gaps = 4/99 (4%)
Query: 26 DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGAR--INVMNRGDDTPLHLAASHGHRDIV 83
D+N + G PLH A +G + ++L+ G++ +N + D PLH + GH DIV
Sbjct: 192 DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIV 251
Query: 84 QKLLQYKADI--NAVNEHGNVPLHYACFWGQDQVAEDLV 120
+ LLQ ++ + VN +G+ PLH AC+ G+ +VA++++
Sbjct: 252 KYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEII 290
Score = 67.0 bits (162), Expect = 3e-11
Identities = 41/130 (31%), Positives = 66/130 (50%), Gaps = 4/130 (3%)
Query: 33 HGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKAD 92
+GF+ LH A + + ++ L+ GA I + G T LH+A GH + LLQ+ A+
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 159
Query: 93 INAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAP----LRELL 148
+N + PLH A ++G +QV L+ GA V++ + G+ P+ A A + +LL
Sbjct: 160 VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLL 219
Query: 149 RERAEKMGQN 158
E K N
Sbjct: 220 MEEGSKADVN 229
Score = 65.1 bits (157), Expect = 1e-10
Identities = 34/103 (33%), Positives = 55/103 (53%)
Query: 26 DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQK 85
D+ Q G + LH A G ++L+ GA +N+ + TPLH+AA +GH + +
Sbjct: 126 DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRL 185
Query: 86 LLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSI 128
LL++ AD+N E G+ PLH A G +A+ L+ G+ +
Sbjct: 186 LLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADV 228
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 134 bits (336), Expect = 2e-31
Identities = 123/514 (23%), Positives = 219/514 (42%), Gaps = 86/514 (16%)
Query: 14 VAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI--NVMNRGDDTPL 71
+A L + ++ D+N D+ PLH+ R G +V+ L+ + +V+N DTPL
Sbjct: 316 IAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL 375
Query: 72 HLAASHGHRDIVQKLLQ--------------------------------YKADINAVN-- 97
HLA +G ++ ++++Q + D N +N
Sbjct: 376 HLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININ 435
Query: 98 ---EHGNVPLHYACFWGQDQVAEDLVANGALVSIC-----NKYGEMPVDKA--------- 140
G+ LH AC+ G ++ + L+ NGA +++ GE
Sbjct: 436 HQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH 495
Query: 141 ----------KAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPR------NGTLNK 184
K P EL + G + + + K + T+ + L
Sbjct: 496 DAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPS 555
Query: 185 HSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRD-FNEECPRLR 243
H + ++ F + G+++KGR + + +K + + ++ D F E L
Sbjct: 556 HFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILC 615
Query: 244 IFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMAR 303
+HP V+ +GAC + P+ ++T ++ GSL+++LHE + QS+ + A+D+A+
Sbjct: 616 QLNHPCVIQFVGACLNDPSQF-AIVTQYISGGSLFSLLHEQKRILDLQSKLI-IAVDVAK 673
Query: 304 GMAFLHTLEPLIPRHALNSRSVMIDEDMTARIS---------MADVKFSFQCPGRMYAPA 354
GM +LH L I LNS ++++ ED A ++ D + PG +
Sbjct: 674 GMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNL---R 730
Query: 355 WVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIP 414
W+APE + T + AD++S+A+ LWE++T E+PFA L +A +RP I
Sbjct: 731 WMAPEVFTQCTRYTIK--ADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIG 788
Query: 415 PGISPHVCKLMKICMNEDPAKRPKFDMIVPILEK 448
I + L+ N P RP+F +V LE+
Sbjct: 789 YSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEE 822
Score = 67.4 bits (163), Expect = 3e-11
Identities = 34/99 (34%), Positives = 59/99 (59%), Gaps = 4/99 (4%)
Query: 26 DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGAR--INVMNRGDDTPLHLAASHGHRDIV 83
D+N + G PLH A +G + ++L+ G++ +N + D PLH + GH DIV
Sbjct: 293 DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIV 352
Query: 84 QKLLQYKADI--NAVNEHGNVPLHYACFWGQDQVAEDLV 120
+ LLQ ++ + VN +G+ PLH AC+ G+ +VA++++
Sbjct: 353 KYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEII 391
Score = 67.0 bits (162), Expect = 3e-11
Identities = 41/130 (31%), Positives = 66/130 (50%), Gaps = 4/130 (3%)
Query: 33 HGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKAD 92
+GF+ LH A + + ++ L+ GA I + G T LH+A GH + LLQ+ A+
Sbjct: 201 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 260
Query: 93 INAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAP----LRELL 148
+N + PLH A ++G +QV L+ GA V++ + G+ P+ A A + +LL
Sbjct: 261 VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLL 320
Query: 149 RERAEKMGQN 158
E K N
Sbjct: 321 MEEGSKADVN 330
Score = 65.1 bits (157), Expect = 1e-10
Identities = 34/103 (33%), Positives = 55/103 (53%)
Query: 26 DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQK 85
D+ Q G + LH A G ++L+ GA +N+ + TPLH+AA +GH + +
Sbjct: 227 DIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRL 286
Query: 86 LLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSI 128
LL++ AD+N E G+ PLH A G +A+ L+ G+ +
Sbjct: 287 LLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADV 329
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 114 bits (285), Expect = 2e-25
Identities = 77/268 (28%), Positives = 120/268 (44%), Gaps = 17/268 (6%)
Query: 188 IDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSH 247
I F L F G +++ +W D V V +K +E L + SH
Sbjct: 11 IKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAV--------KKLLKIEKEAEILSVLSH 62
Query: 248 PNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAF 307
N++ G PP + ++T + GSLY+ ++ + +D + +A D+A+GM +
Sbjct: 63 RNIIQFYGVILEPP--NYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120
Query: 308 LHTLEPLIPRHA-LNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPA---WVAPEALQK 363
LH P+ H L SR+V+I D +I M W+APE +Q
Sbjct: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS 180
Query: 364 KPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCK 423
P + D +S+ V+LWE++TREVPF L +++ V + R TIP +
Sbjct: 181 LPVS---ETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAE 237
Query: 424 LMKICMNEDPAKRPKFDMIVPILEKMQD 451
L+ C D KRP F I+ ILE M +
Sbjct: 238 LLHQCWEADAKKRPSFKQIISILESMSN 265
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 114 bits (285), Expect = 2e-25
Identities = 77/268 (28%), Positives = 120/268 (44%), Gaps = 17/268 (6%)
Query: 188 IDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSH 247
I F L F G +++ +W D V V +K +E L + SH
Sbjct: 11 IKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAV--------KKLLKIEKEAEILSVLSH 62
Query: 248 PNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAF 307
N++ G PP + ++T + GSLY+ ++ + +D + +A D+A+GM +
Sbjct: 63 RNIIQFYGVILEPP--NYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY 120
Query: 308 LHTLEPLIPRHA-LNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPA---WVAPEALQK 363
LH P+ H L SR+V+I D +I M W+APE +Q
Sbjct: 121 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS 180
Query: 364 KPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCK 423
P + D +S+ V+LWE++TREVPF L +++ V + R TIP +
Sbjct: 181 LPVS---ETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAE 237
Query: 424 LMKICMNEDPAKRPKFDMIVPILEKMQD 451
L+ C D KRP F I+ ILE M +
Sbjct: 238 LLHQCWEADAKKRPSFKQIISILESMSN 265
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 106 bits (264), Expect = 5e-23
Identities = 80/278 (28%), Positives = 134/278 (48%), Gaps = 24/278 (8%)
Query: 188 IDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFS- 246
I F +L + G++++ W+G ++ VK ++ D + + C R+F
Sbjct: 93 IPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARL-DPEKDPAVTAEQVCQEARLFGA 151
Query: 247 --HPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARG 304
HPN++ + GAC +PP H L+ + G+L VL V V +A+ +ARG
Sbjct: 152 LQHPNIIALRGACLNPP--HLCLVMEYARGGALSRVL---AGRRVPPHVLVNWAVQVARG 206
Query: 305 MAFLHTLEPL-IPRHALNSRSVMIDE--------DMTARISMADVKFSFQCPGRMYAP-- 353
M +LH P+ I L S +++I E D +I+ + + +M A
Sbjct: 207 MNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGT 266
Query: 354 -AWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPT 412
AW+APE ++ +S+D+WSF VLLWEL+T EVP+ ++ + + VA+ L
Sbjct: 267 YAWMAPEVIRLS---LFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLP 323
Query: 413 IPPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQ 450
IP +L++ C + DP RP F I+ LE ++
Sbjct: 324 IPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIE 361
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 101 bits (252), Expect = 1e-21
Identities = 77/264 (29%), Positives = 121/264 (45%), Gaps = 30/264 (11%)
Query: 188 IDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNE-ECPRLRIFS 246
+ F+++ L + G ++ GR+ G ++ VK K RD E + LR
Sbjct: 120 VPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVK----------KVRDLKETDIKHLRKLK 169
Query: 247 HPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMA 306
HPN++ G C AP ++ + G LY VL G V S V +++ +A GM
Sbjct: 170 HPNIITFKGVCTQ--APCYCILMEFCAQGQLYEVLRAGRP--VTPSLLVDWSMGIAGGMN 225
Query: 307 FLHTLEPLIPRHALNSRSVMIDEDMTARIS-------MADVKFSFQCPGRMYAPAWVAPE 359
+LH L +I R L S +++I D +IS ++D G + AW+APE
Sbjct: 226 YLH-LHKIIHRD-LKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTV---AWMAPE 280
Query: 360 ALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISP 419
++ +P D+WSF V+LWEL+T E+P+ D+ + I V L +P
Sbjct: 281 VIRNEPVS---EKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPD 337
Query: 420 HVCKLMKICMNEDPAKRPKFDMIV 443
L++ C N P RP F I+
Sbjct: 338 GFKILLRQCWNSKPRNRPSFRQIL 361
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 101 bits (252), Expect = 1e-21
Identities = 70/265 (26%), Positives = 127/265 (47%), Gaps = 17/265 (6%)
Query: 188 IDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSH 247
ID+K++ + G + K +W+ D+ +K ++ S RK+ F E +L +H
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIK--QIESESERKA--FIVELRQLSRVNH 86
Query: 248 PNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNF-VVDQSQAVKFALDMARGMA 306
PN++ + GAC +P L+ + GSLYNVLH + A+ + L ++G+A
Sbjct: 87 PNIVKLYGACLNPVC----LVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
Query: 307 FLHTLEP--LIPRHALNSRSVMIDEDMTARISMADVKFSFQC--PGRMYAPAWVAPEALQ 362
+LH+++P LI R +++ +I Q + AW+APE +
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFE 202
Query: 363 KKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALE-GLRPTIPPGISPHV 421
D++S+ ++LWE++TR PF ++ + A+ G RP + + +
Sbjct: 203 GS---NYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPI 259
Query: 422 CKLMKICMNEDPAKRPKFDMIVPIL 446
LM C ++DP++RP + IV I+
Sbjct: 260 ESLMTRCWSKDPSQRPSMEEIVKIM 284
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 101 bits (252), Expect = 1e-21
Identities = 70/265 (26%), Positives = 127/265 (47%), Gaps = 17/265 (6%)
Query: 188 IDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSH 247
ID+K++ + G + K +W+ D+ +K ++ S RK+ F E +L +H
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIK--QIESESERKA--FIVELRQLSRVNH 86
Query: 248 PNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNF-VVDQSQAVKFALDMARGMA 306
PN++ + GAC +P L+ + GSLYNVLH + A+ + L ++G+A
Sbjct: 87 PNIVKLYGACLNPVC----LVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
Query: 307 FLHTLEP--LIPRHALNSRSVMIDEDMTARISMADVKFSFQC--PGRMYAPAWVAPEALQ 362
+LH+++P LI R +++ +I Q + AW+APE +
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFE 202
Query: 363 KKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALE-GLRPTIPPGISPHV 421
D++S+ ++LWE++TR PF ++ + A+ G RP + + +
Sbjct: 203 GS---NYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPI 259
Query: 422 CKLMKICMNEDPAKRPKFDMIVPIL 446
LM C ++DP++RP + IV I+
Sbjct: 260 ESLMTRCWSKDPSQRPSMEEIVKIM 284
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 101 bits (252), Expect = 1e-21
Identities = 70/265 (26%), Positives = 127/265 (47%), Gaps = 17/265 (6%)
Query: 188 IDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSH 247
ID+K++ + G + K +W+ D+ +K ++ S RK+ F E +L +H
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIK--QIESESERKA--FIVELRQLSRVNH 86
Query: 248 PNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNF-VVDQSQAVKFALDMARGMA 306
PN++ + GAC +P L+ + GSLYNVLH + A+ + L ++G+A
Sbjct: 87 PNIVKLYGACLNPVC----LVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
Query: 307 FLHTLEP--LIPRHALNSRSVMIDEDMTARISMADVKFSFQC--PGRMYAPAWVAPEALQ 362
+LH+++P LI R +++ +I Q + AW+APE +
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFE 202
Query: 363 KKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALE-GLRPTIPPGISPHV 421
D++S+ ++LWE++TR PF ++ + A+ G RP + + +
Sbjct: 203 GS---NYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPI 259
Query: 422 CKLMKICMNEDPAKRPKFDMIVPIL 446
LM C ++DP++RP + IV I+
Sbjct: 260 ESLMTRCWSKDPSQRPSMEEIVKIM 284
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 101 bits (252), Expect = 1e-21
Identities = 70/265 (26%), Positives = 127/265 (47%), Gaps = 17/265 (6%)
Query: 188 IDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSH 247
ID+K++ + G + K +W+ D+ +K ++ S RK+ F E +L +H
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIK--QIESESERKA--FIVELRQLSRVNH 86
Query: 248 PNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNF-VVDQSQAVKFALDMARGMA 306
PN++ + GAC +P L+ + GSLYNVLH + A+ + L ++G+A
Sbjct: 87 PNIVKLYGACLNPVC----LVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
Query: 307 FLHTLEP--LIPRHALNSRSVMIDEDMTARISMADVKFSFQC--PGRMYAPAWVAPEALQ 362
+LH+++P LI R +++ +I Q + AW+APE +
Sbjct: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFE 202
Query: 363 KKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALE-GLRPTIPPGISPHV 421
D++S+ ++LWE++TR PF ++ + A+ G RP + + +
Sbjct: 203 GS---NYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPI 259
Query: 422 CKLMKICMNEDPAKRPKFDMIVPIL 446
LM C ++DP++RP + IV I+
Sbjct: 260 ESLMTRCWSKDPSQRPSMEEIVKIM 284
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 98.2 bits (243), Expect = 1e-20
Identities = 73/278 (26%), Positives = 130/278 (46%), Gaps = 22/278 (7%)
Query: 188 IDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLK--VRDWSTRKSRDFNEECPRLRIF 245
IDF +L + G++++ W G+++ VK + + ++ + +E +
Sbjct: 139 IDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAML 198
Query: 246 SHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGM 305
HPN++ + G C P + L+ + G L VL + + V +A+ +ARGM
Sbjct: 199 KHPNIIALRGVCLKEP--NLCLVMEFARGGPLNRVL---SGKRIPPDILVNWAVQIARGM 253
Query: 306 AFLH--TLEPLIPRHALNSRSVMIDEDMTARISMADVKFS-------FQCPGRMYAP--- 353
+LH + P+I R +S +++ + +S +K + + +M A
Sbjct: 254 NYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTY 313
Query: 354 AWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTI 413
AW+APE ++ + +D+WS+ VLLWEL+T EVPF + + + VA+ L I
Sbjct: 314 AWMAPEVIRASMFS---KGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPI 370
Query: 414 PPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQD 451
P KLM+ C N DP RP F I+ L +++
Sbjct: 371 PSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEE 408
>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
sapiens]
Length = 648
Score = 95.5 bits (236), Expect = 9e-20
Identities = 79/306 (25%), Positives = 144/306 (47%), Gaps = 29/306 (9%)
Query: 161 RIPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVK 220
R P T K R R + + + + I+ ++ T++ G ++KG+W G D+ VK
Sbjct: 318 RAPVSGTQEKNKIRPRGQRDS-SYYWEIEASEVMLSTRIGSGSFGTVYKGKWHG-DVAVK 375
Query: 221 VLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNV 280
+LKV D + + + F E LR H N+L +G + ++T W SLY
Sbjct: 376 ILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKD---NLAIVTQWCEGSSLYKH 432
Query: 281 LH-EGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARIS--- 336
LH + T F Q + A A+GM +LH I + S ++ + E +T +I
Sbjct: 433 LHVQETKF--QMFQLIDIARQTAQGMDYLHAKN--IIHRDMKSNNIFLHEGLTVKIGDFG 488
Query: 337 MADVKFSFQCPGRMYAPA----WVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPF 392
+A VK + ++ P W+APE ++ + + +D++S+ ++L+EL+T E+P+
Sbjct: 489 LATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPY 548
Query: 393 ADLSNME-----IGMKVA---LEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIVP 444
+ ++N + +G A L L P + +L+ C+ + +RP F I+
Sbjct: 549 SHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMK----RLVADCVKKVKEERPLFPQILS 604
Query: 445 ILEKMQ 450
+E +Q
Sbjct: 605 SIELLQ 610
>gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]
Length = 999
Score = 95.5 bits (236), Expect = 9e-20
Identities = 81/274 (29%), Positives = 129/274 (47%), Gaps = 32/274 (11%)
Query: 199 LNENHSGELWKGRWQGND-----IVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPV 253
L E G + +G + D + VK +K+ + S R+ +F E ++ FSHPNV+ +
Sbjct: 593 LGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRL 652
Query: 254 LGAC---QSPPAPHPTLITHWMPYGS-----LYNVLHEGTNFVVDQSQAVKFALDMARGM 305
LG C S P P +I +M YG LY+ L G + Q+ +KF +D+A GM
Sbjct: 653 LGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQT-LLKFMVDIALGM 711
Query: 306 AFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFS-------FQCPGRM--YAPAWV 356
+L L L +R+ M+ +DMT + +AD S + GR+ W+
Sbjct: 712 EYLSNRNFL--HRDLAARNCMLRDDMT--VCVADFGLSKKIYSGDYYRQGRIAKMPVKWI 767
Query: 357 APEALQKKPEDTNRRSADMWSFAVLLWELVTREV-PFADLSNMEIGMKVALEGLRPTIPP 415
A E+L + +D+W+F V +WE+ TR + P+ + N E+ L G R P
Sbjct: 768 AIESLADR---VYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEM-YDYLLHGHRLKQPE 823
Query: 416 GISPHVCKLMKICMNEDPAKRPKFDMIVPILEKM 449
+ ++M C DP RP F ++ LEK+
Sbjct: 824 DCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKL 857
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 95.1 bits (235), Expect = 1e-19
Identities = 73/267 (27%), Positives = 129/267 (48%), Gaps = 16/267 (5%)
Query: 188 IDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSH 247
++ K+L L + + G++ G ++GN + VK +K + ++ F E + H
Sbjct: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIK----NDATAQAFLAEASVMTQLRH 245
Query: 248 PNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAF 307
N++ +LG ++T +M GSL + L V+ +KF+LD+ M +
Sbjct: 246 SNLVQLLGVIVEEKGGL-YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304
Query: 308 LHTLEPLIPRHALNSRSVMIDEDMTARIS---MADVKFSFQCPGRMYAPAWVAPEALQKK 364
L L +R+V++ ED A++S + S Q G++ W APEAL++K
Sbjct: 305 LEGNN--FVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK-WTAPEALREK 361
Query: 365 PEDTNRRSADMWSFAVLLWELVT-REVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCK 423
T +D+WSF +LLWE+ + VP+ + ++ +V +G + P G P V +
Sbjct: 362 KFSTK---SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE-KGYKMDAPDGCPPAVYE 417
Query: 424 LMKICMNEDPAKRPKFDMIVPILEKMQ 450
+MK C + D A RP F + LE ++
Sbjct: 418 VMKNCWHLDAAMRPSFLQLREQLEHIK 444
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 95.1 bits (235), Expect = 1e-19
Identities = 73/267 (27%), Positives = 129/267 (48%), Gaps = 16/267 (5%)
Query: 188 IDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSH 247
++ K+L L + + G++ G ++GN + VK +K + ++ F E + H
Sbjct: 190 LNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIK----NDATAQAFLAEASVMTQLRH 245
Query: 248 PNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAF 307
N++ +LG ++T +M GSL + L V+ +KF+LD+ M +
Sbjct: 246 SNLVQLLGVIVEEKGGL-YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304
Query: 308 LHTLEPLIPRHALNSRSVMIDEDMTARIS---MADVKFSFQCPGRMYAPAWVAPEALQKK 364
L L +R+V++ ED A++S + S Q G++ W APEAL++K
Sbjct: 305 LEGNN--FVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK-WTAPEALREK 361
Query: 365 PEDTNRRSADMWSFAVLLWELVT-REVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCK 423
T +D+WSF +LLWE+ + VP+ + ++ +V +G + P G P V +
Sbjct: 362 KFSTK---SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE-KGYKMDAPDGCPPAVYE 417
Query: 424 LMKICMNEDPAKRPKFDMIVPILEKMQ 450
+MK C + D A RP F + LE ++
Sbjct: 418 VMKNCWHLDAAMRPSFLQLREQLEHIK 444
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 95.1 bits (235), Expect = 1e-19
Identities = 72/266 (27%), Positives = 122/266 (45%), Gaps = 22/266 (8%)
Query: 191 KQLNFLTKLNENHSGELWKGRWQGND-IVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPN 249
+ L KL + GE+W G W G + +K LK T F +E ++ H
Sbjct: 275 ESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKP---GTMMPEAFLQEAQIMKKLRHDK 331
Query: 250 VLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLH 309
++P+ P ++T +M GSL + L EG + Q V A +A GMA++
Sbjct: 332 LVPLYAVVSEEPI---YIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIE 388
Query: 310 TLEPLIPRHALNSRSVMIDEDMTARIS-------MADVKFSFQCPGRMYAPAWVAPEALQ 362
+ + L + ++++ E++ +I+ + D +++ + G + W APEA
Sbjct: 389 RMNYI--HRDLRAANILVGENLVCKIADFGLARLIEDNEYTAR-QGAKFPIKWTAPEAAL 445
Query: 363 KKPEDTNRRSADMWSFAVLLWELVTR-EVPFADLSNMEIGMKVALEGLRPTIPPGISPHV 421
+D+WSF +L ELVT+ VP+ + N E+ +V G R P G +
Sbjct: 446 YGRFTIK---SDVWSFGILQTELVTKGRVPYPGMVNREVLEQVE-RGYRMPCPQGCPESL 501
Query: 422 CKLMKICMNEDPAKRPKFDMIVPILE 447
+LM +C +DP +RP F+ I LE
Sbjct: 502 HELMNLCWKKDPDERPTFEYIQSFLE 527
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 95.1 bits (235), Expect = 1e-19
Identities = 71/290 (24%), Positives = 127/290 (43%), Gaps = 33/290 (11%)
Query: 188 IDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKV--RDWSTRKSRDFNEECPRLRIF 245
+ F++L + G++++ WQG ++ VK + + + E +
Sbjct: 119 VAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAML 178
Query: 246 SHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQA----------- 294
HPN++ + G C P H L+ + G+L L N D
Sbjct: 179 RHPNIIELRGVCLQQP--HLCLVLEFARGGALNRAL-AAANAAPDPRAPGPRRARRIPPH 235
Query: 295 --VKFALDMARGMAFLH--TLEPLIPRHALNSRSVMIDE-------DMTARISMADVKFS 343
V +A+ +ARGM +LH P++ R +S +++++ + T +I+ +
Sbjct: 236 VLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLARE 295
Query: 344 FQCPGRMYAP---AWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEI 400
+ +M AW+APE ++ + +D+WS+ VLLWEL+T EVP+ + + +
Sbjct: 296 WHRTTKMSTAGTYAWMAPEVIKSS---LFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAV 352
Query: 401 GMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQ 450
VA+ L IP KLMK C +DP RP F +I+ L ++
Sbjct: 353 AYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIE 402
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 94.0 bits (232), Expect = 3e-19
Identities = 74/276 (26%), Positives = 127/276 (46%), Gaps = 24/276 (8%)
Query: 190 FKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKV---RDWSTRKSRDFNEECPRLRIFS 246
F++L + G++++G W+G + VK + D S + +E + +
Sbjct: 114 FQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVT-AESVRQEARLFAMLA 172
Query: 247 HPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMA 306
HPN++ + C P + L+ + G L L V V +A+ +ARGM
Sbjct: 173 HPNIIALKAVCLEEP--NLCLVMEYAAGGPLSRAL---AGRRVPPHVLVNWAVQIARGMH 227
Query: 307 FLH--TLEPLIPRHALNSRSVMID-------EDMTARISMADVKFSFQCPGRMYAP---A 354
+LH L P+I R ++ +++ E T +I+ + + +M A A
Sbjct: 228 YLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYA 287
Query: 355 WVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIP 414
W+APE ++ T + +D+WSF VLLWEL+T EVP+ + + + VA+ L IP
Sbjct: 288 WMAPEVIKAS---TFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIP 344
Query: 415 PGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQ 450
+LM C +DP +RP F I+ LE ++
Sbjct: 345 STCPEPFAQLMADCWAQDPHRRPDFASILQQLEALE 380
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 93.6 bits (231), Expect = 3e-19
Identities = 72/260 (27%), Positives = 117/260 (45%), Gaps = 30/260 (11%)
Query: 188 IDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNE-ECPRLRIFS 246
+ F++++ L L G ++ G+++ ++ +K K R+ NE + LR
Sbjct: 163 VPFEEISELQWLGSGAQGAVFLGKFRAEEVAIK----------KVREQNETDIKHLRKLK 212
Query: 247 HPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMA 306
HPN++ G C AP +I + +G LY VL G + V ++ +A GM
Sbjct: 213 HPNIIAFKGVCTQ--APCYCIIMEYCAHGQLYEVLRAGRK--ITPRLLVDWSTGIASGMN 268
Query: 307 FLHTLEPLIPRHALNSRSVMIDEDMTARIS-------MADVKFSFQCPGRMYAPAWVAPE 359
+LH L +I R L S +V++ +IS ++D G + AW+APE
Sbjct: 269 YLH-LHKIIHRD-LKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTV---AWMAPE 323
Query: 360 ALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISP 419
++ +P D+WSF V+LWEL+T E+P+ D+ + I V L +P
Sbjct: 324 VIRNEPVS---EKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPD 380
Query: 420 HVCKLMKICMNEDPAKRPKF 439
LMK P RP F
Sbjct: 381 GFKILMKQTWQSKPRNRPSF 400
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 91.3 bits (225), Expect = 2e-18
Identities = 71/253 (28%), Positives = 116/253 (45%), Gaps = 24/253 (9%)
Query: 198 KLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGAC 257
KL GE++ G W+ + V V +++ T + +F +E ++ HPN++ +LG C
Sbjct: 278 KLGGGQYGEVYVGVWKKYSLTVAVKTLKE-DTMEVEEFLKEAAVMKEIKHPNLVQLLGVC 336
Query: 258 QSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPR 317
P + ++T +MPYG+L + L E V + A ++ M +L +
Sbjct: 337 TLEPPFY--IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFI--H 392
Query: 318 HALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAP--------AWVAPEALQKKPEDTN 369
L +R+ ++ E+ ++ AD S G Y W APE+L +T
Sbjct: 393 RDLAARNCLVGENHVVKV--ADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY---NTF 447
Query: 370 RRSADMWSFAVLLWELVTREV---PFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMK 426
+D+W+F VLLWE+ T + P DLS + + +G R P G P V +LM+
Sbjct: 448 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV---YDLLEKGYRMEQPEGCPPKVYELMR 504
Query: 427 ICMNEDPAKRPKF 439
C PA RP F
Sbjct: 505 ACWKWSPADRPSF 517
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 91.3 bits (225), Expect = 2e-18
Identities = 71/253 (28%), Positives = 116/253 (45%), Gaps = 24/253 (9%)
Query: 198 KLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGAC 257
KL GE++ G W+ + V V +++ T + +F +E ++ HPN++ +LG C
Sbjct: 293 KLGGGQYGEVYVGVWKKYSLTVAVKTLKE-DTMEVEEFLKEAAVMKEIKHPNLVQLLGVC 351
Query: 258 QSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPR 317
P + ++T +MPYG+L + L E V + A ++ M +L +
Sbjct: 352 TLEPPFY--IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFI--H 407
Query: 318 HALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAP--------AWVAPEALQKKPEDTN 369
L +R+ ++ E+ ++ AD S G Y W APE+L +T
Sbjct: 408 RDLAARNCLVGENHVVKV--ADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY---NTF 462
Query: 370 RRSADMWSFAVLLWELVTREV---PFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMK 426
+D+W+F VLLWE+ T + P DLS + + +G R P G P V +LM+
Sbjct: 463 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV---YDLLEKGYRMEQPEGCPPKVYELMR 519
Query: 427 ICMNEDPAKRPKF 439
C PA RP F
Sbjct: 520 ACWKWSPADRPSF 532
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 91.3 bits (225), Expect = 2e-18
Identities = 71/253 (28%), Positives = 116/253 (45%), Gaps = 24/253 (9%)
Query: 198 KLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGAC 257
KL GE++ G W+ + V V +++ T + +F +E ++ HPN++ +LG C
Sbjct: 272 KLGGGQYGEVYVGVWKKYSLTVAVKTLKE-DTMEVEEFLKEAAVMKEIKHPNLVQLLGVC 330
Query: 258 QSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPR 317
P + ++T +MPYG+L + L E V + A ++ M +L +
Sbjct: 331 TLEPPFY--IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFI--H 386
Query: 318 HALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAP--------AWVAPEALQKKPEDTN 369
L +R+ ++ E+ ++ AD S G Y W APE+L +T
Sbjct: 387 RDLAARNCLVGENHVVKV--ADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY---NTF 441
Query: 370 RRSADMWSFAVLLWELVTREV---PFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMK 426
+D+W+F VLLWE+ T + P DLS + + +G R P G P V +LM+
Sbjct: 442 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV---YDLLEKGYRMEQPEGCPPKVYELMR 498
Query: 427 ICMNEDPAKRPKF 439
C PA RP F
Sbjct: 499 ACWKWSPADRPSF 511
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 91.3 bits (225), Expect = 2e-18
Identities = 71/253 (28%), Positives = 116/253 (45%), Gaps = 24/253 (9%)
Query: 198 KLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGAC 257
KL GE++ G W+ + V V +++ T + +F +E ++ HPN++ +LG C
Sbjct: 278 KLGGGQYGEVYVGVWKKYSLTVAVKTLKE-DTMEVEEFLKEAAVMKEIKHPNLVQLLGVC 336
Query: 258 QSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPR 317
P + ++T +MPYG+L + L E V + A ++ M +L +
Sbjct: 337 TLEPPFY--IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFI--H 392
Query: 318 HALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAP--------AWVAPEALQKKPEDTN 369
L +R+ ++ E+ ++ AD S G Y W APE+L +T
Sbjct: 393 RDLAARNCLVGENHVVKV--ADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY---NTF 447
Query: 370 RRSADMWSFAVLLWELVTREV---PFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMK 426
+D+W+F VLLWE+ T + P DLS + + +G R P G P V +LM+
Sbjct: 448 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV---YDLLEKGYRMEQPEGCPPKVYELMR 504
Query: 427 ICMNEDPAKRPKF 439
C PA RP F
Sbjct: 505 ACWKWSPADRPSF 517
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 91.3 bits (225), Expect = 2e-18
Identities = 71/253 (28%), Positives = 116/253 (45%), Gaps = 24/253 (9%)
Query: 198 KLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGAC 257
KL GE++ G W+ + V V +++ T + +F +E ++ HPN++ +LG C
Sbjct: 257 KLGGGQYGEVYVGVWKKYSLTVAVKTLKE-DTMEVEEFLKEAAVMKEIKHPNLVQLLGVC 315
Query: 258 QSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPR 317
P + ++T +MPYG+L + L E V + A ++ M +L +
Sbjct: 316 TLEPPFY--IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFI--H 371
Query: 318 HALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAP--------AWVAPEALQKKPEDTN 369
L +R+ ++ E+ ++ AD S G Y W APE+L +T
Sbjct: 372 RDLAARNCLVGENHVVKV--ADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY---NTF 426
Query: 370 RRSADMWSFAVLLWELVTREV---PFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMK 426
+D+W+F VLLWE+ T + P DLS + + +G R P G P V +LM+
Sbjct: 427 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV---YDLLEKGYRMEQPEGCPPKVYELMR 483
Query: 427 ICMNEDPAKRPKF 439
C PA RP F
Sbjct: 484 ACWKWSPADRPSF 496
>gi|33188459 B-Raf [Homo sapiens]
Length = 766
Score = 90.5 bits (223), Expect = 3e-18
Identities = 77/306 (25%), Positives = 143/306 (46%), Gaps = 33/306 (10%)
Query: 163 PYKDTFWKGTTRTRPRNGTLNKHSGIDF-----KQLNFLTKLNENHSGELWKGRWQGNDI 217
P ++ ++ R R TL + D Q+ ++ G ++KG+W G D+
Sbjct: 422 PQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHG-DV 480
Query: 218 VVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSL 277
VK+L V + ++ + F E LR H N+L +G P ++T W SL
Sbjct: 481 AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQL---AIVTQWCEGSSL 537
Query: 278 YNVLHE-GTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARIS 336
Y+ LH T F + + + A A+GM +LH I L S ++ + ED+T +I
Sbjct: 538 YHHLHIIETKF--EMIKLIDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIG 593
Query: 337 ---MADVKF----SFQCPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTRE 389
+A VK S Q + W+APE ++ + ++ +D+++F ++L+EL+T +
Sbjct: 594 DFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQ 653
Query: 390 VPFADLSNME-----IG---MKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDM 441
+P+++++N + +G + L +R P + +LM C+ + +RP F
Sbjct: 654 LPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMK----RLMAECLKKKRDERPLFPQ 709
Query: 442 IVPILE 447
I+ +E
Sbjct: 710 ILASIE 715
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 90.1 bits (222), Expect = 4e-18
Identities = 68/266 (25%), Positives = 119/266 (44%), Gaps = 22/266 (8%)
Query: 191 KQLNFLTKLNENHSGELWKGRWQGN-DIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPN 249
+ L + +L GE+W G W GN + +K LK T F EE ++ H
Sbjct: 269 ESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKP---GTMSPESFLEEAQIMKKLKHDK 325
Query: 250 VLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLH 309
++ + P ++T +M GSL + L +G + V A +A GMA++
Sbjct: 326 LVQLYAVVSEEPI---YIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 382
Query: 310 TLEPLIPRHALNSRSVMIDEDMTARIS-------MADVKFSFQCPGRMYAPAWVAPEALQ 362
+ + L S ++++ + +I+ + D +++ + G + W APEA
Sbjct: 383 RMNYI--HRDLRSANILVGNGLICKIADFGLARLIEDNEYTAR-QGAKFPIKWTAPEAAL 439
Query: 363 KKPEDTNRRSADMWSFAVLLWELVTR-EVPFADLSNMEIGMKVALEGLRPTIPPGISPHV 421
+D+WSF +LL ELVT+ VP+ ++N E+ ++ G R P +
Sbjct: 440 ---YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREV-LEQVERGYRMPCPQDCPISL 495
Query: 422 CKLMKICMNEDPAKRPKFDMIVPILE 447
+LM C +DP +RP F+ + LE
Sbjct: 496 HELMIHCWKKDPEERPTFEYLQSFLE 521
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 89.4 bits (220), Expect = 6e-18
Identities = 66/266 (24%), Positives = 120/266 (45%), Gaps = 22/266 (8%)
Query: 188 IDFKQLNFLTKLNENHSGELWKGRWQGND-IVVKVLKVRDWSTRKSRDFNEECPRLRIFS 246
ID + L +L GE+W+G W + VK LK + DF E ++
Sbjct: 229 IDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKP---GSMDPNDFLREAQIMKNLR 285
Query: 247 HPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMA 306
HP ++ + C + +IT M +GSL L T + +Q V A +A GMA
Sbjct: 286 HPKLIQLYAVCTLEDPIY--IITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMA 343
Query: 307 FLHTLEPLIPRHALNSRSVMIDEDM--------TARISMADVKFSFQCPGRMYAPA-WVA 357
+L + + L +R+V++ E AR+ D + ++ + P W A
Sbjct: 344 YLESRNYI--HRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401
Query: 358 PEALQKKPEDTNRRSADMWSFAVLLWELVT-REVPFADLSNMEIGMKVALEGLRPTIPPG 416
PEA++ +D+WSF +LL+E++T ++P++ ++ ++ +++ + R P
Sbjct: 402 PEAIRSNKFSI---KSDVWSFGILLYEIITYGKMPYSGMTGAQV-IQMLAQNYRLPQPSN 457
Query: 417 ISPHVCKLMKICMNEDPAKRPKFDMI 442
+M C N +P +RP F+ +
Sbjct: 458 CPQQFYNIMLECWNAEPKERPTFETL 483
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.430
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,190,074
Number of Sequences: 37866
Number of extensions: 820682
Number of successful extensions: 5352
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 481
Number of HSP's successfully gapped in prelim test: 433
Number of HSP's that attempted gapping in prelim test: 2244
Number of HSP's gapped (non-prelim): 2342
length of query: 452
length of database: 18,247,518
effective HSP length: 106
effective length of query: 346
effective length of database: 14,233,722
effective search space: 4924867812
effective search space used: 4924867812
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.