Search of human proteins with 4505545

Search of human proteins with 4505545

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4505545 purinergic receptor P2X1 [Homo sapiens]
         (399 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4505545 purinergic receptor P2X1 [Homo sapiens]                    825   0.0  
gi|28416927 purinergic receptor P2X4 [Homo sapiens]                   423   e-118
gi|28416925 purinergic receptor P2X3 [Homo sapiens]                   319   3e-87
gi|157419148 purinergic receptor P2X6 isoform 1 [Homo sapiens]        316   2e-86
gi|28416933 purinergic receptor P2X5 isoform A [Homo sapiens]         310   1e-84
gi|28416923 purinergic receptor P2X2 isoform B [Homo sapiens]         299   3e-81
gi|25092719 purinergic receptor P2X2 isoform A [Homo sapiens]         299   3e-81
gi|29294631 purinergic receptor P2X7 [Homo sapiens]                   292   4e-79
gi|25092733 purinergic receptor P2X2 isoform D [Homo sapiens]         285   7e-77
gi|227116341 purinergic receptor P2X6 isoform 2 [Homo sapiens]        284   9e-77
gi|7706629 purinergic receptor P2X2 isoform C [Homo sapiens]          272   4e-73
gi|28416935 purinergic receptor P2X5 isoform B [Homo sapiens]         267   1e-71
gi|28416921 purinergic receptor P2X2 isoform H [Homo sapiens]         214   1e-55
gi|27881423 purinergic receptor P2X2 isoform I [Homo sapiens]         207   1e-53
gi|28416937 purinergic receptor P2X5 isoform C [Homo sapiens]         164   1e-40

>gi|4505545 purinergic receptor P2X1 [Homo sapiens]
          Length = 399

 Score =  825 bits (2130), Expect = 0.0
 Identities = 399/399 (100%), Positives = 399/399 (100%)

Query: 1   MARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSG 60
           MARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSG
Sbjct: 1   MARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSG 60

Query: 61  LISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEH 120
           LISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEH
Sbjct: 61  LISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEH 120

Query: 121 PEGGICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLR 180
           PEGGICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLR
Sbjct: 121 PEGGICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLR 180

Query: 181 EAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESG 240
           EAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESG
Sbjct: 181 EAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESG 240

Query: 241 QNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNLSPGFNFRFARHFVEN 300
           QNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNLSPGFNFRFARHFVEN
Sbjct: 241 QNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNLSPGFNFRFARHFVEN 300

Query: 301 GTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKR 360
           GTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKR
Sbjct: 301 GTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKR 360

Query: 361 HYYKQKKFKYAEDMGPGAAERDLAATSSTLGLQENMRTS 399
           HYYKQKKFKYAEDMGPGAAERDLAATSSTLGLQENMRTS
Sbjct: 361 HYYKQKKFKYAEDMGPGAAERDLAATSSTLGLQENMRTS 399


>gi|28416927 purinergic receptor P2X4 [Homo sapiens]
          Length = 388

 Score =  423 bits (1087), Expect = e-118
 Identities = 195/376 (51%), Positives = 273/376 (72%), Gaps = 5/376 (1%)

Query: 9   LAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSGLISSVSVK 68
           LAAFLFEYDTPR+VL+R++KVG++ R +QL++L YVIGWVF++EKGYQ +  ++SSV+ K
Sbjct: 8   LAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTK 67

Query: 69  LKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEHPEGG-ICK 127
           +KG+AVT    LG ++WDVADYV PAQ +NS  VMTN I+T  QTQG C E P+   +CK
Sbjct: 68  VKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCK 127

Query: 128 EDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLREAENFTL 187
            D+ CT G A   + G+ TG+CVAFN +VKTCE+  WCPVE D  +P+PA L+ AENFTL
Sbjct: 128 SDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTL 187

Query: 188 FIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESGQNFSTLA 247
            +KN+I +P+F  ++RN++  +   ++K+C++     P CP+F+LG +V+ +G +F  +A
Sbjct: 188 LVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAGHSFQDMA 247

Query: 248 EKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYE---EKNLSPGFNFRFARHFVE-NGTN 303
            +GG++GI ++W C+LD     C P Y F  L     E N+SPG+NFRFA+++ +  G  
Sbjct: 248 VEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNE 307

Query: 304 YRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYY 363
            R L K +GIRFDI+V GKAGKFDIIPTM  IGSG+ + G+ATVLCD+++L+ + KR YY
Sbjct: 308 QRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYY 367

Query: 364 KQKKFKYAEDMGPGAA 379
           ++KK+KY ED   G A
Sbjct: 368 REKKYKYVEDYEQGLA 383


>gi|28416925 purinergic receptor P2X3 [Homo sapiens]
          Length = 397

 Score =  319 bits (817), Expect = 3e-87
 Identities = 169/361 (46%), Positives = 231/361 (63%), Gaps = 14/361 (3%)

Query: 14  FEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSGLI-SSVSVKLKGL 72
           F Y+T + V+V++  +G+I R++QL+++ Y +GWVFL+EK YQ     I SSV  K+KG 
Sbjct: 8   FTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGS 67

Query: 73  AVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEHPEGGICKEDSGC 132
            +        +V DV+DYV P QG + FV++T  IVT  Q QG+C E  E   C  DS C
Sbjct: 68  GL-----YANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQC 122

Query: 133 TPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLREAENFTLFIKNS 192
            P +      GI TG+CV ++  ++TCEI GWCP EVD  +  P ++ EAENFT+FIKNS
Sbjct: 123 GPERLP--GGGILTGRCVNYSSVLRTCEIQGWCPTEVDT-VETPIMM-EAENFTIFIKNS 178

Query: 193 ISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESGQNFSTLAEKGGV 252
           I FP F   + NL+  + A  MKTC FH    P CP+ ++G VV+ +GQ+F+ LA  GGV
Sbjct: 179 IRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGV 238

Query: 253 VGITIDWHCDLDWHVRHCRPIYEF---HGLYEEKNLSPGFNFRFARHF-VENGTNYRHLF 308
           +GI I W CDLD     C P Y F     + E+ ++SPG+NFRFA+++ +ENG+ YR L 
Sbjct: 239 LGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLL 298

Query: 309 KVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKF 368
           K FGIRFD+LV G AGKF+IIPT+ +  +     GV TVLCD++LL+ L     YK KKF
Sbjct: 299 KAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKF 358

Query: 369 K 369
           +
Sbjct: 359 E 359


>gi|157419148 purinergic receptor P2X6 isoform 1 [Homo sapiens]
          Length = 441

 Score =  316 bits (810), Expect = 2e-86
 Identities = 172/394 (43%), Positives = 238/394 (60%), Gaps = 16/394 (4%)

Query: 13  LFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSGLIS-SVSVKLKG 71
           L +Y T + V+ RN +VG + RL+Q  ++VYV+GW  L +KGYQ        S+  KLKG
Sbjct: 22  LLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLAKKGYQERDLEPQFSIITKLKG 81

Query: 72  LAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEHPEGGI--CKED 129
           ++VTQ+  LG ++WDVAD+V P QG+N F ++TNF+VTP Q QG C EHP   +  C  D
Sbjct: 82  VSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTPAQVQGRCPEHPSVPLANCWVD 141

Query: 130 SGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLREAENFTLFI 189
             C  G+    + G++TG+CV FN T +TCEI+ WCPVE    +P   LL +A+NFTLFI
Sbjct: 142 EDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVE-SGVVPSRPLLAQAQNFTLFI 200

Query: 190 KNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESGQNFSTLAEK 249
           KN+++F +F  ++ N +E  +  + K C +     P CPVF++G +V ++G  F  LA  
Sbjct: 201 KNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPVFRIGDLVAKAGGTFEDLALL 260

Query: 250 GGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNLSPGFNFRFARHFVEN-GTNYRHLF 308
           GG VGI + W CDLD     C P Y F    +EK+    +NFR A H+ E  G   R L 
Sbjct: 261 GGSVGIRVHWDCDLDTGDSGCWPHYSFQ--LQEKS----YNFRTATHWWEQPGVEARTLL 314

Query: 309 KVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKF 368
           K++GIRFDILV G+AGKF +IPT  T+G+G    GV T  CDLLLL++  + H+Y   + 
Sbjct: 315 KLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLLYVDREAHFY--WRT 372

Query: 369 KYAEDMGPGAAERDL---AATSSTLGLQENMRTS 399
           KY E   P A    +    A +S   L E +R S
Sbjct: 373 KYEEAKAPKATANSVWRELALASQARLAECLRRS 406


>gi|28416933 purinergic receptor P2X5 isoform A [Homo sapiens]
          Length = 422

 Score =  310 bits (795), Expect = 1e-84
 Identities = 165/396 (41%), Positives = 243/396 (61%), Gaps = 35/396 (8%)

Query: 9   LAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQ-TSSGLISSVSV 67
           L   LF+Y T + V+ +NKKVG+++RL+Q  +L Y++ WVFL +KGYQ   + L S+V  
Sbjct: 9   LCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSAVIT 68

Query: 68  KLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEHPEG---G 124
           K+KG+A T    LG ++WDVADYV PAQG+N F V+TN IVTP Q Q  CAE+ EG   G
Sbjct: 69  KVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAEN-EGIPDG 127

Query: 125 ICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVK-TCEIFGWCPVEVDDDIPRPALLREAE 183
            C +DS C  G+A     G++TG+C+   +  + TCEIF WCP+E     P    L+EAE
Sbjct: 128 ACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSR-PEEPFLKEAE 186

Query: 184 NFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESGQNF 243
           +FT+FIKN I FP+F  ++ N+++  + + +K+C F    H  CP+F+LG V++ +G +F
Sbjct: 187 DFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPKNH-YCPIFRLGSVIRWAGSDF 245

Query: 244 STLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEE--KNLSPGFNFRFARHFVE-N 300
             +A +GGV+GI I+W+CDLD     C P Y F  L  +  K++S G+NFRFAR++ +  
Sbjct: 246 QDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARYYRDAA 305

Query: 301 GTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKR 360
           G  +R L K +GIRFD++V+GK   F                      CDL+L++++ KR
Sbjct: 306 GVEFRTLMKAYGIRFDVMVNGKGAFF----------------------CDLVLIYLIKKR 343

Query: 361 HYYKQKKFKYAEDMGPGAAERDLAATSSTLGLQENM 396
            +Y+ K  KY E  G   + ++    +S LGL E +
Sbjct: 344 EFYRDK--KYEEVRGLEDSSQEAEDEASGLGLSEQL 377


>gi|28416923 purinergic receptor P2X2 isoform B [Homo sapiens]
          Length = 404

 Score =  299 bits (765), Expect = 3e-81
 Identities = 149/373 (39%), Positives = 233/373 (62%), Gaps = 14/373 (3%)

Query: 2   ARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTS-SG 60
           ARR      + L++Y+TP++++VRN+++GV++R +QL++L+Y + +VF+ +K YQ S +G
Sbjct: 14  ARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETG 73

Query: 61  LISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAE- 119
             SS+  K+KG+  ++      +VWDV +YV P +G + F ++T    T  QTQG C E 
Sbjct: 74  PESSIITKVKGITTSE-----HKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPES 128

Query: 120 -HPEGGICKEDSGCTPGKAKRKAQGIRTGKCVAF-NDTVKTCEIFGWCPVEVDDDIPRPA 177
                  C  D+ C  G+      G+RTG+CV +     KTCE+FGWCPVE    + +  
Sbjct: 129 IRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQ-F 187

Query: 178 LLREAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQ 237
           L   A NFT+ IKNSI +P+F  ++ N+ +  +  ++K C FH+     CP+F+LG++V+
Sbjct: 188 LGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDG-YLKRCTFHEASDLYCPIFKLGFIVE 246

Query: 238 ESGQNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNL--SPGFNFRFAR 295
           ++G++F+ LA KGGV+G+ I+W CDLD     C P Y F  L + K++  S G+NFRFA+
Sbjct: 247 KAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRL-DPKHVPASSGYNFRFAK 305

Query: 296 HFVENGTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLH 355
           ++  NGT  R L K +GIR D++V G+AGKF +IPT+  + + +   GV + LCD +LL 
Sbjct: 306 YYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLT 365

Query: 356 ILPKRHYYKQKKF 368
            + K   Y  KKF
Sbjct: 366 FMNKNKVYSHKKF 378


>gi|25092719 purinergic receptor P2X2 isoform A [Homo sapiens]
          Length = 471

 Score =  299 bits (765), Expect = 3e-81
 Identities = 149/373 (39%), Positives = 233/373 (62%), Gaps = 14/373 (3%)

Query: 2   ARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTS-SG 60
           ARR      + L++Y+TP++++VRN+++GV++R +QL++L+Y + +VF+ +K YQ S +G
Sbjct: 14  ARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETG 73

Query: 61  LISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAE- 119
             SS+  K+KG+  ++      +VWDV +YV P +G + F ++T    T  QTQG C E 
Sbjct: 74  PESSIITKVKGITTSE-----HKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPES 128

Query: 120 -HPEGGICKEDSGCTPGKAKRKAQGIRTGKCVAF-NDTVKTCEIFGWCPVEVDDDIPRPA 177
                  C  D+ C  G+      G+RTG+CV +     KTCE+FGWCPVE    + +  
Sbjct: 129 IRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQ-F 187

Query: 178 LLREAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQ 237
           L   A NFT+ IKNSI +P+F  ++ N+ +  +  ++K C FH+     CP+F+LG++V+
Sbjct: 188 LGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDG-YLKRCTFHEASDLYCPIFKLGFIVE 246

Query: 238 ESGQNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNL--SPGFNFRFAR 295
           ++G++F+ LA KGGV+G+ I+W CDLD     C P Y F  L + K++  S G+NFRFA+
Sbjct: 247 KAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRL-DPKHVPASSGYNFRFAK 305

Query: 296 HFVENGTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLH 355
           ++  NGT  R L K +GIR D++V G+AGKF +IPT+  + + +   GV + LCD +LL 
Sbjct: 306 YYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLT 365

Query: 356 ILPKRHYYKQKKF 368
            + K   Y  KKF
Sbjct: 366 FMNKNKVYSHKKF 378


>gi|29294631 purinergic receptor P2X7 [Homo sapiens]
          Length = 595

 Score =  292 bits (747), Expect = 4e-79
 Identities = 153/352 (43%), Positives = 214/352 (60%), Gaps = 17/352 (4%)

Query: 13  LFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSGLISSVSVKLKGL 72
           +F+Y+T ++  +++   G I     +++  YV  +  + +K YQ    +ISSV  K+KG+
Sbjct: 10  VFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVC-FALVSDKLYQRKEPVISSVHTKVKGI 68

Query: 73  AVTQ-------LPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEHP-EGG 124
           A  +       +  L   V+D ADY FP QG NSF VMTNF+ T  Q Q  C E+P    
Sbjct: 69  AEVKEEIVENGVKKLVHSVFDTADYTFPLQG-NSFFVMTNFLKTEGQEQRLCPEYPTRRT 127

Query: 125 ICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLREAEN 184
           +C  D GC  G    +++GI+TG+CV +    KTCE+  WCP+E  ++ PRPALL  AEN
Sbjct: 128 LCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAEN 187

Query: 185 FTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESGQNFS 244
           FT+ IKN+I FP      RN++  +N     TC FHKT +P CP+F+LG + +E+G NFS
Sbjct: 188 FTVLIKNNIDFPGHNYTTRNILPGLNI----TCTFHKTQNPQCPIFRLGDIFRETGDNFS 243

Query: 245 TLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEK---NLSPGFNFRFARHFVENG 301
            +A +GG++GI I W C+LD    HCRP Y F  L ++    +L PG+NFR+A+++ EN 
Sbjct: 244 DVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENN 303

Query: 302 TNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLL 353
              R L KVFGIRFDILV G  GKFDII  +  IGS +  FG+A V  D L+
Sbjct: 304 VEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLI 355


>gi|25092733 purinergic receptor P2X2 isoform D [Homo sapiens]
          Length = 497

 Score =  285 bits (728), Expect = 7e-77
 Identities = 149/399 (37%), Positives = 233/399 (58%), Gaps = 40/399 (10%)

Query: 2   ARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTS-SG 60
           ARR      + L++Y+TP++++VRN+++GV++R +QL++L+Y + +VF+ +K YQ S +G
Sbjct: 14  ARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETG 73

Query: 61  LISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAE- 119
             SS+  K+KG+  ++      +VWDV +YV P +G + F ++T    T  QTQG C E 
Sbjct: 74  PESSIITKVKGITTSE-----HKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPES 128

Query: 120 -HPEGGICKEDSGCTPGKAKRKAQGIRTGKCVAF-NDTVKTCEIFGWCPVEVDDDIPRPA 177
                  C  D+ C  G+      G+RTG+CV +     KTCE+FGWCPVE    + +  
Sbjct: 129 IRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQ-F 187

Query: 178 LLREAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQ 237
           L   A NFT+ IKNSI +P+F  ++ N+ +  +  ++K C FH+     CP+F+LG++V+
Sbjct: 188 LGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDG-YLKRCTFHEASDLYCPIFKLGFIVE 246

Query: 238 ESGQNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNL--SPGFNFRFAR 295
           ++G++F+ LA KGGV+G+ I+W CDLD     C P Y F  L + K++  S G+NFRFA+
Sbjct: 247 KAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRL-DPKHVPASSGYNFRFAK 305

Query: 296 HFVENGTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGV----------- 344
           ++  NGT  R L K +GIR D++V G+AGKF +IPT+  + + +   GV           
Sbjct: 306 YYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVVRNPLWGPSGC 365

Query: 345 ---------------ATVLCDLLLLHILPKRHYYKQKKF 368
                           + LCD +LL  + K   Y  KKF
Sbjct: 366 GGSTRPLHTGLCWPQGSFLCDWILLTFMNKNKVYSHKKF 404


>gi|227116341 purinergic receptor P2X6 isoform 2 [Homo sapiens]
          Length = 415

 Score =  284 bits (727), Expect = 9e-77
 Identities = 157/360 (43%), Positives = 214/360 (59%), Gaps = 16/360 (4%)

Query: 47  WVFLYEKGYQTSSGLIS-SVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTN 105
           W  L +KGYQ        S+  KLKG++VTQ+  LG ++WDVAD+V P QG+N F ++TN
Sbjct: 30  WALLAKKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTN 89

Query: 106 FIVTPKQTQGYCAEHPEGGI--CKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFG 163
           F+VTP Q QG C EHP   +  C  D  C  G+    + G++TG+CV FN T +TCEI+ 
Sbjct: 90  FLVTPAQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWS 149

Query: 164 WCPVEVDDDIPRPALLREAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTL 223
           WCPVE    +P   LL +A+NFTLFIKN+++F +F  ++ N +E  +  + K C +    
Sbjct: 150 WCPVE-SGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQF 208

Query: 224 HPLCPVFQLGYVVQESGQNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEK 283
            P CPVF++G +V ++G  F  LA  GG VGI + W CDLD     C P Y F    +EK
Sbjct: 209 SPYCPVFRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQ--LQEK 266

Query: 284 NLSPGFNFRFARHFVEN-GTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIF 342
           +    +NFR A H+ E  G   R L K++GIRFDILV G+AGKF +IPT  T+G+G    
Sbjct: 267 S----YNFRTATHWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWL 322

Query: 343 GVATVLCDLLLLHILPKRHYYKQKKFKYAEDMGPGAAERDL---AATSSTLGLQENMRTS 399
           GV T  CDLLLL++  + H+Y   + KY E   P A    +    A +S   L E +R S
Sbjct: 323 GVVTFFCDLLLLYVDREAHFY--WRTKYEEAKAPKATANSVWRELALASQARLAECLRRS 380


>gi|7706629 purinergic receptor P2X2 isoform C [Homo sapiens]
          Length = 447

 Score =  272 bits (695), Expect = 4e-73
 Identities = 139/371 (37%), Positives = 221/371 (59%), Gaps = 34/371 (9%)

Query: 2   ARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTS-SG 60
           ARR      + L++Y+TP++++VRN+++GV++R +QL++L+Y + +VF+ +K YQ S +G
Sbjct: 14  ARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETG 73

Query: 61  LISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEH 120
             SS+  K+KG+  ++      +VWDV +YV P +                      +  
Sbjct: 74  PESSIITKVKGITTSE-----HKVWDVEEYVKPPE----------------------SIR 106

Query: 121 PEGGICKEDSGCTPGKAKRKAQGIRTGKCVAF-NDTVKTCEIFGWCPVEVDDDIPRPALL 179
                C  D+ C  G+      G+RTG+CV +     KTCE+FGWCPVE    + +  L 
Sbjct: 107 VHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQ-FLG 165

Query: 180 REAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQES 239
             A NFT+ IKNSI +P+F  ++ N+ +  +  ++K C FH+     CP+F+LG++V+++
Sbjct: 166 TMAPNFTILIKNSIHYPKFHFSKGNIADRTDG-YLKRCTFHEASDLYCPIFKLGFIVEKA 224

Query: 240 GQNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNL--SPGFNFRFARHF 297
           G++F+ LA KGGV+G+ I+W CDLD     C P Y F  L + K++  S G+NFRFA+++
Sbjct: 225 GESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRL-DPKHVPASSGYNFRFAKYY 283

Query: 298 VENGTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHIL 357
             NGT  R L K +GIR D++V G+AGKF +IPT+  + + +   GV + LCD +LL  +
Sbjct: 284 KINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFM 343

Query: 358 PKRHYYKQKKF 368
            K   Y  KKF
Sbjct: 344 NKNKVYSHKKF 354


>gi|28416935 purinergic receptor P2X5 isoform B [Homo sapiens]
          Length = 397

 Score =  267 bits (683), Expect = 1e-71
 Identities = 149/393 (37%), Positives = 225/393 (57%), Gaps = 54/393 (13%)

Query: 9   LAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQ-TSSGLISSVSV 67
           L   LF+Y T + V+ +NKKVG+++RL+Q  +L Y++ WVFL +KGYQ   + L S+V  
Sbjct: 9   LCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSAVIT 68

Query: 68  KLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEHPEGGICK 127
           K+KG+A T    LG ++WDVADYV PAQ +                       P+G  C 
Sbjct: 69  KVKGVAFTNTSDLGQRIWDVADYVIPAQNEGI---------------------PDGA-CS 106

Query: 128 EDSGCTPGKAKRKAQGIRTGKCVAFNDTVK-TCEIFGWCPVEVDDDIPRPALLREAENFT 186
           +DS C  G+A     G++TG+C+   +  + TCEIF WCP+E     P    L+EAE+FT
Sbjct: 107 KDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSR-PEEPFLKEAEDFT 165

Query: 187 LFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESGQNFSTL 246
           +FIKN I FP+F  +  N+++  + + +K+C F    H  CP+F+LG V++ +G +F  +
Sbjct: 166 IFIKNHIRFPKFNFSN-NVMDVKDRSFLKSCHFGPKNH-YCPIFRLGSVIRWAGSDFQDI 223

Query: 247 AEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEE--KNLSPGFNFRFARHFVE-NGTN 303
           A +GGV+GI I+W+CDLD     C P Y F  L  +  K++S G+NFRFAR++ +  G  
Sbjct: 224 ALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARYYRDAAGVE 283

Query: 304 YRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYY 363
           +R L K +GIRFD++V+GK   F                      CDL+L++++ KR +Y
Sbjct: 284 FRTLMKAYGIRFDVMVNGKGAFF----------------------CDLVLIYLIKKREFY 321

Query: 364 KQKKFKYAEDMGPGAAERDLAATSSTLGLQENM 396
           + K  KY E  G   + ++    +S LGL E +
Sbjct: 322 RDK--KYEEVRGLEDSSQEAEDEASGLGLSEQL 352


>gi|28416921 purinergic receptor P2X2 isoform H [Homo sapiens]
          Length = 379

 Score =  214 bits (545), Expect = 1e-55
 Identities = 103/246 (41%), Positives = 154/246 (62%), Gaps = 6/246 (2%)

Query: 126 CKEDSGCTPGKAKRKAQGIRTGKCVAF-NDTVKTCEIFGWCPVEVDDDIPRPALLREAEN 184
           C  D+ C  G+      G+RTG+CV +     KTCE+FGWCPVE    + +  L   A N
Sbjct: 44  CLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQ-FLGTMAPN 102

Query: 185 FTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESGQNFS 244
           FT+ IKNSI +P+F  ++ N+ +  +  ++K C FH+     CP+F+LG++V+++G++F+
Sbjct: 103 FTILIKNSIHYPKFHFSKGNIADRTDG-YLKRCTFHEASDLYCPIFKLGFIVEKAGESFT 161

Query: 245 TLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNL--SPGFNFRFARHFVENGT 302
            LA KGGV+G+ I+W CDLD     C P Y F  L + K++  S G+NFRFA+++  NGT
Sbjct: 162 ELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRL-DPKHVPASSGYNFRFAKYYKINGT 220

Query: 303 NYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHY 362
             R L K +GIR D++V G+AGKF +IPT+  + + +   GV + LCD +LL  + K   
Sbjct: 221 TTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKV 280

Query: 363 YKQKKF 368
           Y  KKF
Sbjct: 281 YSHKKF 286


>gi|27881423 purinergic receptor P2X2 isoform I [Homo sapiens]
          Length = 399

 Score =  207 bits (527), Expect = 1e-53
 Identities = 100/237 (42%), Positives = 151/237 (63%), Gaps = 6/237 (2%)

Query: 135 GKAKRKAQGIRTGKCVAF-NDTVKTCEIFGWCPVEVDDDIPRPALLREAENFTLFIKNSI 193
           G  +   +G+RTG+CV +     KTCE+FGWCPVE    + +  L   A NFT+ IKNSI
Sbjct: 73  GGVREAPRGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQ-FLGTMAPNFTILIKNSI 131

Query: 194 SFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESGQNFSTLAEKGGVV 253
            +P+F  ++ N+ +  +  ++K C FH+     CP+F+LG++V+++G++F+ LA KGGV+
Sbjct: 132 HYPKFHFSKGNIADRTDG-YLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVI 190

Query: 254 GITIDWHCDLDWHVRHCRPIYEFHGLYEEKNL--SPGFNFRFARHFVENGTNYRHLFKVF 311
           G+ I+W CDLD     C P Y F  L + K++  S G+NFRFA+++  NGT  R L K +
Sbjct: 191 GVIINWDCDLDLPASECNPKYSFRRL-DPKHVPASSGYNFRFAKYYKINGTTTRTLIKAY 249

Query: 312 GIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKF 368
           GIR D++V G+AGKF +IPT+  + + +   GV + LCD +LL  + K   Y  KKF
Sbjct: 250 GIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKF 306


>gi|28416937 purinergic receptor P2X5 isoform C [Homo sapiens]
          Length = 178

 Score =  164 bits (415), Expect = 1e-40
 Identities = 81/165 (49%), Positives = 111/165 (67%), Gaps = 6/165 (3%)

Query: 9   LAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQ-TSSGLISSVSV 67
           L   LF+Y T + V+ +NKKVG+++RL+Q  +L Y++ WVFL +KGYQ   + L S+V  
Sbjct: 9   LCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSAVIT 68

Query: 68  KLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEHPEG---G 124
           K+KG+A T    LG ++WDVADYV PAQG+N F V+TN IVTP Q Q  CAE+ EG   G
Sbjct: 69  KVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAEN-EGIPDG 127

Query: 125 ICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVK-TCEIFGWCPVE 168
            C +DS C  G+A     G++TG+C+   +  + TCEIF WCP+E
Sbjct: 128 ACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLE 172


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.141    0.443 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,450,394
Number of Sequences: 37866
Number of extensions: 693090
Number of successful extensions: 1583
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 1490
Number of HSP's gapped (non-prelim): 17
length of query: 399
length of database: 18,247,518
effective HSP length: 104
effective length of query: 295
effective length of database: 14,309,454
effective search space: 4221288930
effective search space used: 4221288930
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.