Search of human proteins with 41349456

Search of human proteins with 41349456

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|41349456 prolyl endopeptidase [Homo sapiens]
         (710 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|41349456 prolyl endopeptidase [Homo sapiens]                      1483   0.0  
gi|70778815 prolyl endopeptidase-like isoform C [Homo sapiens]        100   5e-21
gi|108860686 prolyl endopeptidase-like isoform E [Homo sapiens]        97   4e-20
gi|108860692 prolyl endopeptidase-like isoform D [Homo sapiens]        94   6e-19
gi|194394146 dipeptidylpeptidase 9 [Homo sapiens]                      37   0.048
gi|23510451 N-acylaminoacyl-peptide hydrolase [Homo sapiens]           35   0.31 
gi|37577089 dipeptidyl peptidase 8 isoform 3 [Homo sapiens]            35   0.31 
gi|18450280 dipeptidyl peptidase 8 isoform 1 [Homo sapiens]            35   0.31 
gi|85787627 dipeptidyl peptidase 10 isoform short [Homo sapiens]       32   2.7  
gi|52426756 dipeptidyl peptidase 10 isoform long [Homo sapiens]        32   2.7  

>gi|41349456 prolyl endopeptidase [Homo sapiens]
          Length = 710

 Score = 1483 bits (3838), Expect = 0.0
 Identities = 710/710 (100%), Positives = 710/710 (100%)

Query: 1   MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR 60
           MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
Sbjct: 1   MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR 60

Query: 61  GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS 120
           GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS
Sbjct: 61  GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS 120

Query: 121 DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH 180
           DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH
Sbjct: 121 DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH 180

Query: 181 DGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL 240
           DGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL
Sbjct: 181 DGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL 240

Query: 241 SDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVF 300
           SDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVF
Sbjct: 241 SDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVF 300

Query: 301 TFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNI 360
           TFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNI
Sbjct: 301 TFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNI 360

Query: 361 LQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR 420
           LQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR
Sbjct: 361 LQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR 420

Query: 421 VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI 480
           VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
Sbjct: 421 VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI 480

Query: 481 TPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE 540
           TPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
Sbjct: 481 TPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE 540

Query: 541 GYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG 600
           GYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG
Sbjct: 541 GYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG 600

Query: 601 CSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV 660
           CSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
Sbjct: 601 CSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV 660

Query: 661 GRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP 710
           GRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP
Sbjct: 661 GRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP 710


>gi|70778815 prolyl endopeptidase-like isoform C [Homo sapiens]
          Length = 727

 Score =  100 bits (249), Expect = 5e-21
 Identities = 108/430 (25%), Positives = 185/430 (43%), Gaps = 46/430 (10%)

Query: 231 EPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLQQE-------SSGIAGILKWVKLI 283
           +P +     L+ D R++ ++I       + +W  D              I G+L +V+  
Sbjct: 249 DPSYFVFLYLTKDSRFLTINIMN--KTTSEVWLIDGLSPWDPPVLIQKRIHGVLYYVEHR 306

Query: 284 DNFEGEYDYVTNEGTVFTFKTNRQSPNY-RVINIDFRDPEESKWKVLVPEHEKDVLEWIA 342
           D+   E   +TN G    FK  R + +   ++N D     +   KV+  +  KD      
Sbjct: 307 DD---ELYILTNVGEPTEFKLMRTAADTPAIMNWDLFFTMKRNTKVIDLDMFKD-----H 358

Query: 343 CV----RSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQF 398
           CV     SN L +       N++ L D +  +L K  P   G I+  +   K+    +Q 
Sbjct: 359 CVLFLKHSNLLYV-------NVIGLADDSVRSL-KLPPWACGFIMDTNSDPKNCP--FQL 408

Query: 399 TSFLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKK 458
            S + P   Y    T +  E ++F E   +       + +++   SKDG  +PM + HK 
Sbjct: 409 CSPIRPPKYY----TYKFAEGKLFEETGHEDPITKTSRVLRLEAKSKDGKLVPMTVFHKT 464

Query: 459 GIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGG 518
             +     P  ++ YG + + +  N+   R + V   G ILA  ++RGGGE G  WH  G
Sbjct: 465 DSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDD-GWILAYCHVRGGGELGLQWHADG 523

Query: 519 ILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQV 578
            L  K N   D +   + L  +G++ P   T+   S GG+L  A  N  P+L   V  + 
Sbjct: 524 RLTKKLNGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEA 583

Query: 579 GVMDMLKFHKYT---IGHAWTTDYG-CSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSML 634
             +D+L     T   +      ++G  S  ++H  ++ +Y P  N+K P+     YPS+ 
Sbjct: 584 PFLDVLNTMMDTTLPLTLEELEEWGNPSSDEKHKNYIKRYCPYQNIK-PQ----HYPSIH 638

Query: 635 LLTADHDDRV 644
           +   ++D+RV
Sbjct: 639 ITAYENDERV 648


>gi|108860686 prolyl endopeptidase-like isoform E [Homo sapiens]
          Length = 665

 Score = 97.4 bits (241), Expect = 4e-20
 Identities = 92/374 (24%), Positives = 155/374 (41%), Gaps = 37/374 (9%)

Query: 284 DNFEGEYDYVTNEGTVFTFKTNRQSPNYRVINIDFRDPEE-------SKWK--VLVPEHE 334
           DN   E  Y   + + F F    +   +  INI  +   E       S W   VL+ +  
Sbjct: 237 DNKRNERFYTEKDPSYFVFLYLTKDSRFLTINIMNKTTSEVWLIDGLSPWDPPVLIQKRI 296

Query: 335 KDVLEWIACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEI 394
             VL ++             H    +  L ++      K  P   G I+  +   K+   
Sbjct: 297 HGVLYYVE------------HRDDELYILTNVGEPTEFKLPPWACGFIMDTNSDPKNCP- 343

Query: 395 FYQFTSFLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFI 454
            +Q  S + P   Y    T +  E ++F E   +       + +++   SKDG  +PM +
Sbjct: 344 -FQLCSPIRPPKYY----TYKFAEGKLFEETGHEDPITKTSRVLRLEAKSKDGKLVPMTV 398

Query: 455 VHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGILAVANIRGGGEYGETW 514
            HK   +     P  ++ YG + + +  N+   R + V   G ILA  ++RGGGE G  W
Sbjct: 399 FHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDD-GWILAYCHVRGGGELGLQW 457

Query: 515 HKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCV 574
           H  G L  K N   D +   + L  +G++ P   T+   S GG+L  A  N  P+L   V
Sbjct: 458 HADGRLTKKLNGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAV 517

Query: 575 IAQVGVMDMLKFHKYT---IGHAWTTDYG-CSDSKQHFEWLVKYSPLHNVKLPEADDIQY 630
             +   +D+L     T   +      ++G  S  ++H  ++ +Y P  N+K P+     Y
Sbjct: 518 TLEAPFLDVLNTMMDTTLPLTLEELEEWGNPSSDEKHKNYIKRYCPYQNIK-PQ----HY 572

Query: 631 PSMLLLTADHDDRV 644
           PS+ +   ++D+RV
Sbjct: 573 PSIHITAYENDERV 586


>gi|108860692 prolyl endopeptidase-like isoform D [Homo sapiens]
          Length = 661

 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 60/204 (29%), Positives = 98/204 (48%), Gaps = 10/204 (4%)

Query: 445 KDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGILAVANI 504
           KDG  +PM + HK   +     P  ++ YG + + +  N+   R + V   G ILA  ++
Sbjct: 385 KDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDD-GWILAYCHV 443

Query: 505 RGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACA 564
           RGGGE G  WH  G L  K N   D +   + L  +G++ P   T+   S GG+L  A  
Sbjct: 444 RGGGELGLQWHADGRLTKKLNGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALC 503

Query: 565 NQRPDLFGCVIAQVGVMDMLKFHKYT---IGHAWTTDYG-CSDSKQHFEWLVKYSPLHNV 620
           N  P+L   V  +   +D+L     T   +      ++G  S  ++H  ++ +Y P  N+
Sbjct: 504 NSNPELVRAVTLEAPFLDVLNTMMDTTLPLTLEELEEWGNPSSDEKHKNYIKRYCPYQNI 563

Query: 621 KLPEADDIQYPSMLLLTADHDDRV 644
           K P+     YPS+ +   ++D+RV
Sbjct: 564 K-PQ----HYPSIHITAYENDERV 582


>gi|194394146 dipeptidylpeptidase 9 [Homo sapiens]
          Length = 892

 Score = 37.4 bits (85), Expect = 0.048
 Identities = 40/170 (23%), Positives = 69/170 (40%), Gaps = 16/170 (9%)

Query: 418 EPRVFREVTVKGIDASDYQTVQIF-YPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGF 476
           +PR +  +        DY   +IF + ++   ++   I     ++    HP  L+ YGG 
Sbjct: 617 QPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGP 676

Query: 477 NISITPN----YSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANK------QNC 526
            + +  N        RL  +  +G  + V + RG  + G  +   G L N+      ++ 
Sbjct: 677 QVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFE--GALKNQMGQVEIEDQ 734

Query: 527 FDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIA 576
            +  Q  AE   K G+    R+ I+G S GG L       +P +F   IA
Sbjct: 735 VEGLQFVAE---KYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIA 781


>gi|23510451 N-acylaminoacyl-peptide hydrolase [Homo sapiens]
          Length = 732

 Score = 34.7 bits (78), Expect = 0.31
 Identities = 37/165 (22%), Positives = 67/165 (40%), Gaps = 26/165 (15%)

Query: 495 MGGILAVANIRGGGEYGETWHKGGILANKQNC----FDDFQCAAEYLIKEGYTSPKRLTI 550
           MG  + + N RG   +G+      IL+   N       D Q A E +++E +     + +
Sbjct: 528 MGFAVLLVNYRGSTGFGQD----SILSLPGNVGHQDVKDVQFAVEQVLQEEHFDASHVAL 583

Query: 551 NGGSNGGLLVAACANQRPDLFGCVIAQ---------VGVMDMLKFHKYTIGHAWTTDYGC 601
            GGS+GG +      Q P+ +   +A+         +G  D+  +     G  +++D  C
Sbjct: 584 MGGSHGGFISCHLIGQYPETYRACVARNPVINIASMLGSTDIPDWCVVEAGFPFSSD--C 641

Query: 602 SDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVP 646
                 +  ++  SP+  +        Q  + LLL    +DR VP
Sbjct: 642 LPDLSVWAEMLDKSPIRYIP-------QVKTPLLLMLGQEDRRVP 679


>gi|37577089 dipeptidyl peptidase 8 isoform 3 [Homo sapiens]
          Length = 898

 Score = 34.7 bits (78), Expect = 0.31
 Identities = 37/149 (24%), Positives = 58/149 (38%), Gaps = 6/149 (4%)

Query: 434 DYQTVQIF-YPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPN----YSVSR 488
           DY   +IF + S  G  +   +     ++    +P  L+ YGG  + +  N        R
Sbjct: 629 DYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFR 688

Query: 489 LIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE-GYTSPKR 547
           L  +  +G ++ V + RG    G  +         Q   DD     +YL     +    R
Sbjct: 689 LNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDR 748

Query: 548 LTINGGSNGGLLVAACANQRPDLFGCVIA 576
           + I+G S GG L      QR D+F   IA
Sbjct: 749 VGIHGWSYGGYLSLMALMQRSDIFRVAIA 777


>gi|18450280 dipeptidyl peptidase 8 isoform 1 [Homo sapiens]
          Length = 882

 Score = 34.7 bits (78), Expect = 0.31
 Identities = 37/149 (24%), Positives = 58/149 (38%), Gaps = 6/149 (4%)

Query: 434 DYQTVQIF-YPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPN----YSVSR 488
           DY   +IF + S  G  +   +     ++    +P  L+ YGG  + +  N        R
Sbjct: 613 DYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFR 672

Query: 489 LIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE-GYTSPKR 547
           L  +  +G ++ V + RG    G  +         Q   DD     +YL     +    R
Sbjct: 673 LNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDR 732

Query: 548 LTINGGSNGGLLVAACANQRPDLFGCVIA 576
           + I+G S GG L      QR D+F   IA
Sbjct: 733 VGIHGWSYGGYLSLMALMQRSDIFRVAIA 761


>gi|85787627 dipeptidyl peptidase 10 isoform short [Homo sapiens]
          Length = 789

 Score = 31.6 bits (70), Expect = 2.7
 Identities = 31/124 (25%), Positives = 52/124 (41%), Gaps = 11/124 (8%)

Query: 533 AAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIG 592
           A ++L+K  Y   KRL+I G   GG + +        LF C      + D+  +      
Sbjct: 623 AVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDLKLY-----A 677

Query: 593 HAWTTDYGCSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKF 652
            A++  Y    SK+   +    S LHNV       ++  ++L++    D +V   HS + 
Sbjct: 678 SAFSERYLGMPSKEESTYQAA-SVLHNV-----HGLKEENILIIHGTADTKVHFQHSAEL 731

Query: 653 IATL 656
           I  L
Sbjct: 732 IKHL 735


>gi|52426756 dipeptidyl peptidase 10 isoform long [Homo sapiens]
          Length = 796

 Score = 31.6 bits (70), Expect = 2.7
 Identities = 31/124 (25%), Positives = 52/124 (41%), Gaps = 11/124 (8%)

Query: 533 AAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIG 592
           A ++L+K  Y   KRL+I G   GG + +        LF C      + D+  +      
Sbjct: 630 AVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDLKLY-----A 684

Query: 593 HAWTTDYGCSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKF 652
            A++  Y    SK+   +    S LHNV       ++  ++L++    D +V   HS + 
Sbjct: 685 SAFSERYLGMPSKEESTYQAA-SVLHNV-----HGLKEENILIIHGTADTKVHFQHSAEL 738

Query: 653 IATL 656
           I  L
Sbjct: 739 IKHL 742


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.139    0.435 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,405,823
Number of Sequences: 37866
Number of extensions: 1310050
Number of successful extensions: 2364
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 2349
Number of HSP's gapped (non-prelim): 13
length of query: 710
length of database: 18,247,518
effective HSP length: 109
effective length of query: 601
effective length of database: 14,120,124
effective search space: 8486194524
effective search space used: 8486194524
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.