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Search of human proteins with 39995064
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|39995064 pannexin 1 [Homo sapiens]
(426 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|39995064 pannexin 1 [Homo sapiens] 843 0.0
gi|16418453 pannexin 3 [Homo sapiens] 273 2e-73
gi|163659920 pannexin 2 isoform 1 [Homo sapiens] 127 1e-29
gi|237757297 pannexin 2 isoform 2 [Homo sapiens] 127 1e-29
gi|197333692 leucine rich repeat containing 8 family, member B [... 41 0.002
gi|21245134 leucine rich repeat containing 8 family, member B [H... 41 0.002
gi|164607124 Fanconi anemia, complementation group I isoform 1 [... 33 0.49
gi|82830440 Fanconi anemia, complementation group I isoform 2 [H... 33 0.49
gi|197333706 leucine rich repeat containing 8 family, member D [... 33 0.64
gi|34222199 leucine rich repeat containing 8 family, member D [H... 33 0.64
>gi|39995064 pannexin 1 [Homo sapiens]
Length = 426
Score = 843 bits (2178), Expect = 0.0
Identities = 426/426 (100%), Positives = 426/426 (100%)
Query: 1 MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISI 60
MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISI
Sbjct: 1 MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISI 60
Query: 61 GTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILL 120
GTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILL
Sbjct: 61 GTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILL 120
Query: 121 YLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSVPGVTENLG 180
YLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSVPGVTENLG
Sbjct: 121 YLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSVPGVTENLG 180
Query: 181 QSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSSL 240
QSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSSL
Sbjct: 181 QSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSSL 240
Query: 241 SDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPFR 300
SDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPFR
Sbjct: 241 SDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPFR 300
Query: 301 QKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLENIKSSGQG 360
QKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLENIKSSGQG
Sbjct: 301 QKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLENIKSSGQG 360
Query: 361 IDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANNGEKNARQR 420
IDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANNGEKNARQR
Sbjct: 361 IDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANNGEKNARQR 420
Query: 421 LLDSSC 426
LLDSSC
Sbjct: 421 LLDSSC 426
>gi|16418453 pannexin 3 [Homo sapiens]
Length = 392
Score = 273 bits (698), Expect = 2e-73
Identities = 154/360 (42%), Positives = 225/360 (62%), Gaps = 8/360 (2%)
Query: 1 MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISI 60
M++A A EY+ SD LL + P+ KGLRLEL +D++V +AVG PLLL+SLAFAQE S
Sbjct: 1 MSLAHTAAEYMLSDALLPDRRGPRLKGLRLELPLDRIVKFVAVGSPLLLMSLAFAQEFSS 60
Query: 61 GTQISCFSPSSFSWRQAAFVDSYCW-AAVQQKNSLQSESGNLPLWLHKFFPYILLLFAIL 119
G+ ISCFSPS+FS RQAA+VDS CW + + K + LW HK PY LL A+L
Sbjct: 61 GSPISCFSPSNFSIRQAAYVDSSCWDSLLHHKQDGPGQDKMKSLWPHKALPYSLLALALL 120
Query: 120 LYLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSVPGVTENL 179
+YLP L W++AA P + SDL FI+ ELDK YNR+I+ + + + S P V N
Sbjct: 121 MYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQHMLKIRQKS---SDPYVFWNE 177
Query: 180 GQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSS 239
+ + E +F++P++E+YL K+ S++L+ Y+ L LI +YLG++
Sbjct: 178 LEKARK--ERYFEFPLLERYLACKQRSHSLVATYLLRNSLLLIFTSATYLYLGHFHLDVF 235
Query: 240 LSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPF 299
+EF CSIK+G+L +++ VP+ C+L ++ IFQ++S+ ++ +Y +L PV++Y L
Sbjct: 236 FQEEFSCSIKTGLLSDETHVPNLITCRLTSLSIFQIVSLSSVAIYTILVPVIIYNLTRLC 295
Query: 300 RQKTDVLKVYEILPTFDVLHFKSEG--YNDLSLYNLFLEENISEVKSYKCLKVLENIKSS 357
R +L VYE+LP FD+L K G NDL++ LFL NISE+ S+ L VL +K +
Sbjct: 296 RWDKRLLSVYEMLPAFDLLSRKMLGCPINDLNVILLFLRANISELISFSWLSVLCVLKDT 355
>gi|163659920 pannexin 2 isoform 1 [Homo sapiens]
Length = 677
Score = 127 bits (320), Expect = 1e-29
Identities = 90/336 (26%), Positives = 174/336 (51%), Gaps = 20/336 (5%)
Query: 28 LRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAA 87
L+LEL D++VT V +P+LL++L F + + I C++P +F+ QA + YCW
Sbjct: 44 LKLELPFDRVVTIGTVLVPILLVTLVFTKNFA-EEPIYCYTPHNFTRDQALYARGYCWTE 102
Query: 88 VQQKNSLQSESGNL--PLWLHKFFPYILLLFAILLYLPPLFWRFAAAPHICSDLKFIMEE 145
+ +++L +L L+ HKF PY LL FA ++Y+P L W F A+ + S+L F+++E
Sbjct: 103 L--RDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQE 160
Query: 146 LDKVYNRAI--KAAKSARDLDMRDGACSVPGVTENLGQSLWEVSESHFKYP---IVEQYL 200
+D Y+RA +A K + + + PG+TE + + E +E K P + E+YL
Sbjct: 161 IDNCYHRAAEGRAPKIEKQIQSKG-----PGITEREKREIIENAEKE-KSPEQNLFEKYL 214
Query: 201 KTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSSLSDEFVCSIKSGILRNDSTVP 260
+ + SN L Y++ +L L++ + YL Y++ + +EF C++ + P
Sbjct: 215 ERRGRSNFLAKLYLARHVLILLLSAVPISYLCTYYA-TQKQNEFTCALGASPDGAAGAGP 273
Query: 261 D-QFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTL--FVPFRQKTDVLKVYEILPTFDV 317
+ CKL +V + ++++ +++V+ ++ +++ L FR+ + +
Sbjct: 274 AVRVSCKLPSVQLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTR 333
Query: 318 LHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLEN 353
++ + D+++ +F EN +KS L + N
Sbjct: 334 RQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITN 369
>gi|237757297 pannexin 2 isoform 2 [Homo sapiens]
Length = 643
Score = 127 bits (320), Expect = 1e-29
Identities = 90/336 (26%), Positives = 174/336 (51%), Gaps = 20/336 (5%)
Query: 28 LRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAA 87
L+LEL D++VT V +P+LL++L F + + I C++P +F+ QA + YCW
Sbjct: 44 LKLELPFDRVVTIGTVLVPILLVTLVFTKNFA-EEPIYCYTPHNFTRDQALYARGYCWTE 102
Query: 88 VQQKNSLQSESGNL--PLWLHKFFPYILLLFAILLYLPPLFWRFAAAPHICSDLKFIMEE 145
+ +++L +L L+ HKF PY LL FA ++Y+P L W F A+ + S+L F+++E
Sbjct: 103 L--RDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQE 160
Query: 146 LDKVYNRAI--KAAKSARDLDMRDGACSVPGVTENLGQSLWEVSESHFKYP---IVEQYL 200
+D Y+RA +A K + + + PG+TE + + E +E K P + E+YL
Sbjct: 161 IDNCYHRAAEGRAPKIEKQIQSKG-----PGITEREKREIIENAEKE-KSPEQNLFEKYL 214
Query: 201 KTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSSLSDEFVCSIKSGILRNDSTVP 260
+ + SN L Y++ +L L++ + YL Y++ + +EF C++ + P
Sbjct: 215 ERRGRSNFLAKLYLARHVLILLLSAVPISYLCTYYA-TQKQNEFTCALGASPDGAAGAGP 273
Query: 261 D-QFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTL--FVPFRQKTDVLKVYEILPTFDV 317
+ CKL +V + ++++ +++V+ ++ +++ L FR+ + +
Sbjct: 274 AVRVSCKLPSVQLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTR 333
Query: 318 LHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLEN 353
++ + D+++ +F EN +KS L + N
Sbjct: 334 RQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITN 369
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 41.2 bits (95), Expect = 0.002
Identities = 57/258 (22%), Positives = 103/258 (39%), Gaps = 47/258 (18%)
Query: 104 WLHKFFPYILLLFAILLYLPPLFW-----------RFAAAPHICSDLKFIMEELD----- 147
W KFFPY++LL ++ FW F A H C D + L
Sbjct: 116 WFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAE 175
Query: 148 ------KVYNRAIKAAKSARDLDMRDGACSVP--------GVTENLGQSLWEVSESHFKY 193
K+ I + S D+ G S+P E+ S+ + E
Sbjct: 176 QSVRPLKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQAK 235
Query: 194 PIVEQYLKTKKN--SNNLIIK-YISCRLLTLIIILLACIYLGYYFSLSSLSDEFVCSIKS 250
I E+ + + + ++I + Y+ ++ +I+ +L Y+ Y+ L+ ++ E CS+
Sbjct: 236 AIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYF--LTHITLEIDCSVDV 293
Query: 251 GILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPFRQKTDVLKVYE 310
T ++QC IF++L+ +++ +L Y+L+ R LK Y
Sbjct: 294 QAF----TGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSS---LKQY- 345
Query: 311 ILPTFDVLHFKSEGYNDL 328
+F+ L KS Y+D+
Sbjct: 346 ---SFEALREKS-NYSDI 359
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 41.2 bits (95), Expect = 0.002
Identities = 57/258 (22%), Positives = 103/258 (39%), Gaps = 47/258 (18%)
Query: 104 WLHKFFPYILLLFAILLYLPPLFW-----------RFAAAPHICSDLKFIMEELD----- 147
W KFFPY++LL ++ FW F A H C D + L
Sbjct: 116 WFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAE 175
Query: 148 ------KVYNRAIKAAKSARDLDMRDGACSVP--------GVTENLGQSLWEVSESHFKY 193
K+ I + S D+ G S+P E+ S+ + E
Sbjct: 176 QSVRPLKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQAK 235
Query: 194 PIVEQYLKTKKN--SNNLIIK-YISCRLLTLIIILLACIYLGYYFSLSSLSDEFVCSIKS 250
I E+ + + + ++I + Y+ ++ +I+ +L Y+ Y+ L+ ++ E CS+
Sbjct: 236 AIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYF--LTHITLEIDCSVDV 293
Query: 251 GILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPFRQKTDVLKVYE 310
T ++QC IF++L+ +++ +L Y+L+ R LK Y
Sbjct: 294 QAF----TGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSS---LKQY- 345
Query: 311 ILPTFDVLHFKSEGYNDL 328
+F+ L KS Y+D+
Sbjct: 346 ---SFEALREKS-NYSDI 359
>gi|164607124 Fanconi anemia, complementation group I isoform 1
[Homo sapiens]
Length = 1328
Score = 33.1 bits (74), Expect = 0.49
Identities = 38/111 (34%), Positives = 52/111 (46%), Gaps = 15/111 (13%)
Query: 307 KVYEILPTFDVLHFKSEGYNDLSLY--NLFLEENISEVKSYKCLKVLENIKSSGQGIDPM 364
+V ++L T V FK DL L + FL+ N+ +SY +LE +K+S D +
Sbjct: 325 QVLDLLKTSVVKSFK-----DLQLLQGSKFLQ-NLVPHRSYVSTMILEVVKNSVHSWDHV 378
Query: 365 LL-LTNLGMIKMD------VVDGKTPMSAEMREEQGNQTAELQGMNIDSET 408
L LG I MD V+DGKT ++ NQ A G NI ET
Sbjct: 379 TQGLVELGFILMDSYGPKKVLDGKTIETSPSLSRMPNQHACKLGANILLET 429
>gi|82830440 Fanconi anemia, complementation group I isoform 2 [Homo
sapiens]
Length = 1268
Score = 33.1 bits (74), Expect = 0.49
Identities = 38/111 (34%), Positives = 52/111 (46%), Gaps = 15/111 (13%)
Query: 307 KVYEILPTFDVLHFKSEGYNDLSLY--NLFLEENISEVKSYKCLKVLENIKSSGQGIDPM 364
+V ++L T V FK DL L + FL+ N+ +SY +LE +K+S D +
Sbjct: 325 QVLDLLKTSVVKSFK-----DLQLLQGSKFLQ-NLVPHRSYVSTMILEVVKNSVHSWDHV 378
Query: 365 LL-LTNLGMIKMD------VVDGKTPMSAEMREEQGNQTAELQGMNIDSET 408
L LG I MD V+DGKT ++ NQ A G NI ET
Sbjct: 379 TQGLVELGFILMDSYGPKKVLDGKTIETSPSLSRMPNQHACKLGANILLET 429
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 32.7 bits (73), Expect = 0.64
Identities = 15/47 (31%), Positives = 24/47 (51%), Gaps = 2/47 (4%)
Query: 104 WLHKFFPYILLLFAILLYLPPLFWRFAAAPHICSDLKFIMEELDKVY 150
W K+FPY+ L+ I+L + FW P CS ++ + L K +
Sbjct: 160 WYSKYFPYLALIHTIILMVSSNFW--FKYPKTCSKVEHFVSILGKCF 204
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 32.7 bits (73), Expect = 0.64
Identities = 15/47 (31%), Positives = 24/47 (51%), Gaps = 2/47 (4%)
Query: 104 WLHKFFPYILLLFAILLYLPPLFWRFAAAPHICSDLKFIMEELDKVY 150
W K+FPY+ L+ I+L + FW P CS ++ + L K +
Sbjct: 160 WYSKYFPYLALIHTIILMVSSNFW--FKYPKTCSKVEHFVSILGKCF 204
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,518,293
Number of Sequences: 37866
Number of extensions: 589381
Number of successful extensions: 1595
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1577
Number of HSP's gapped (non-prelim): 12
length of query: 426
length of database: 18,247,518
effective HSP length: 105
effective length of query: 321
effective length of database: 14,271,588
effective search space: 4581179748
effective search space used: 4581179748
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.