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Search of human proteins with 31377568
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo
sapiens]
(993 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens] 2164 0.0
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens] 1447 0.0
gi|10190748 CEGP1 protein [Homo sapiens] 1294 0.0
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens] 273 8e-73
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens] 273 8e-73
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 244 4e-64
gi|56237021 fibrillin 3 precursor [Homo sapiens] 235 1e-61
gi|24430141 fibrillin 1 precursor [Homo sapiens] 220 6e-57
gi|66346695 fibrillin 2 precursor [Homo sapiens] 215 2e-55
gi|46249414 latent transforming growth factor beta binding prote... 203 7e-52
gi|46249412 latent transforming growth factor beta binding prote... 203 7e-52
gi|34734066 fibulin 1 isoform D [Homo sapiens] 197 4e-50
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 197 5e-50
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens] 197 5e-50
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens] 197 5e-50
gi|4557733 latent transforming growth factor beta binding protei... 196 1e-49
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens] 193 8e-49
gi|110347437 latent transforming growth factor beta binding prot... 189 8e-48
gi|110347412 latent transforming growth factor beta binding prot... 189 8e-48
gi|110347431 latent transforming growth factor beta binding prot... 189 8e-48
gi|194328809 latent transforming growth factor beta binding prot... 187 3e-47
gi|18497288 latent transforming growth factor beta binding prote... 187 3e-47
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens] 184 3e-46
gi|118572606 hemicentin 1 [Homo sapiens] 167 6e-41
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 162 1e-39
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 162 1e-39
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 162 1e-39
gi|19743803 fibulin 5 precursor [Homo sapiens] 146 8e-35
gi|148886654 polydom [Homo sapiens] 145 2e-34
gi|190343004 EGF-containing fibulin-like extracellular matrix pr... 141 3e-33
>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
Length = 993
Score = 2164 bits (5607), Expect = 0.0
Identities = 993/993 (100%), Positives = 993/993 (100%)
Query: 1 MGSGRVPGLCLLVLLVHARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSG 60
MGSGRVPGLCLLVLLVHARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSG
Sbjct: 1 MGSGRVPGLCLLVLLVHARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSG 60
Query: 61 YTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGN 120
YTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGN
Sbjct: 61 YTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGN 120
Query: 121 GGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGI 180
GGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGI
Sbjct: 121 GGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGI 180
Query: 181 ACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETC 240
ACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETC
Sbjct: 181 ACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETC 240
Query: 241 AVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFE 300
AVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFE
Sbjct: 241 AVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFE 300
Query: 301 CSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITHCGDVDE 360
CSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITHCGDVDE
Sbjct: 301 CSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITHCGDVDE 360
Query: 361 CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSG 420
CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSG
Sbjct: 361 CSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSG 420
Query: 421 KKDTCALTCPSRARFLPESENGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEAAVLSIK 480
KKDTCALTCPSRARFLPESENGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEAAVLSIK
Sbjct: 421 KKDTCALTCPSRARFLPESENGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEAAVLSIK 480
Query: 481 QRASFKIKDAKCRLHLRNKGKTEEAGRITGPGGAPCSECQVTFIHLKCDSSRKGKGRRAR 540
QRASFKIKDAKCRLHLRNKGKTEEAGRITGPGGAPCSECQVTFIHLKCDSSRKGKGRRAR
Sbjct: 481 QRASFKIKDAKCRLHLRNKGKTEEAGRITGPGGAPCSECQVTFIHLKCDSSRKGKGRRAR 540
Query: 541 TPPGKEVTRLTLELEAEVRAEETTASCGLPCLRQRMERRLKGSLKMLRKSINQDRFLLRL 600
TPPGKEVTRLTLELEAEVRAEETTASCGLPCLRQRMERRLKGSLKMLRKSINQDRFLLRL
Sbjct: 541 TPPGKEVTRLTLELEAEVRAEETTASCGLPCLRQRMERRLKGSLKMLRKSINQDRFLLRL 600
Query: 601 AGLDYELAHKPGLVAGERAEPMESCRPGQHRAGTKCVSCPQGTYYHGQTEQCVPCPAGTF 660
AGLDYELAHKPGLVAGERAEPMESCRPGQHRAGTKCVSCPQGTYYHGQTEQCVPCPAGTF
Sbjct: 601 AGLDYELAHKPGLVAGERAEPMESCRPGQHRAGTKCVSCPQGTYYHGQTEQCVPCPAGTF 660
Query: 661 QEREGQLSCDLCPGSDAHGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPRGTYQPEAGR 720
QEREGQLSCDLCPGSDAHGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPRGTYQPEAGR
Sbjct: 661 QEREGQLSCDLCPGSDAHGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPRGTYQPEAGR 720
Query: 721 TLCFPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAMGSYQPDFRQNFCS 780
TLCFPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAMGSYQPDFRQNFCS
Sbjct: 721 TLCFPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAMGSYQPDFRQNFCS 780
Query: 781 RCPGNTSTDFDGSTSVAQCKNRQCGGELGEFTGYIESPNYPGNYPAGVECIWNINPPPKR 840
RCPGNTSTDFDGSTSVAQCKNRQCGGELGEFTGYIESPNYPGNYPAGVECIWNINPPPKR
Sbjct: 781 RCPGNTSTDFDGSTSVAQCKNRQCGGELGEFTGYIESPNYPGNYPAGVECIWNINPPPKR 840
Query: 841 KILIVVPEIFLPSEDECGDVLVMRKNSSPSSITTYETCQTYERPIAFTARSRKLWINFKT 900
KILIVVPEIFLPSEDECGDVLVMRKNSSPSSITTYETCQTYERPIAFTARSRKLWINFKT
Sbjct: 841 KILIVVPEIFLPSEDECGDVLVMRKNSSPSSITTYETCQTYERPIAFTARSRKLWINFKT 900
Query: 901 SEANSARGFQIPYVTYDEDYEQLVEDIVRDGRLYASENHQEILKDKKLIKAFFEVLAHPQ 960
SEANSARGFQIPYVTYDEDYEQLVEDIVRDGRLYASENHQEILKDKKLIKAFFEVLAHPQ
Sbjct: 901 SEANSARGFQIPYVTYDEDYEQLVEDIVRDGRLYASENHQEILKDKKLIKAFFEVLAHPQ 960
Query: 961 NYFKYTEKHKEMLPKSFIKLLRSKVSSFLRPYK 993
NYFKYTEKHKEMLPKSFIKLLRSKVSSFLRPYK
Sbjct: 961 NYFKYTEKHKEMLPKSFIKLLRSKVSSFLRPYK 993
>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
Length = 988
Score = 1447 bits (3745), Expect = 0.0
Identities = 653/991 (65%), Positives = 775/991 (78%), Gaps = 18/991 (1%)
Query: 9 LCLLVLL-VHARAAQYS--KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDG 65
LC+L+ L R A S + DVDEC EGTD+CHIDAICQNTP+SYKC+CK GY G+G
Sbjct: 10 LCVLLALGTRGRLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEG 69
Query: 66 KHCKDVDECERED-NAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQ 124
K C+D+DECE + N GCVH+C+NIPGNYRCTC+DGF LAHDGHNCLDVDEC + NGGCQ
Sbjct: 70 KQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQ 129
Query: 125 QSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACEC 184
Q CVN MGSYEC C GFFLSDNQHTCI R EGMNCMNK+HGCAHICRETPKGG+AC+C
Sbjct: 130 QICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDC 189
Query: 185 RPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNN 244
RPGF+L +NQ+DC LTCNYGNGGCQH+C+DT+ GP CGCH K+ LH+DG+TCIETCAVNN
Sbjct: 190 RPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNN 249
Query: 245 GGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCK 304
GGCD C D ATGV C+CPVGF LQPD KTCKDI+EC +NNGGCDH CRNTVGSFEC C+
Sbjct: 250 GGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCR 309
Query: 305 KGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSIN 364
KGYKLL +ER CQDIDECSF+RTCDHIC+N+PGSFQCLCHRGY+LYG THCGDVDECS++
Sbjct: 310 KGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTTHCGDVDECSMS 369
Query: 365 RGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGAS-KAMLSCNRSGKKD 423
G C GC+NT GSY+C CP G+ RLHWNGKDC E KC S +A LSC+++G +
Sbjct: 370 NGSCDQGCVNTKGSYECVCPPGR-RLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVE 428
Query: 424 TCALTCPSRARFLPESENGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEAAVLSIKQRA 483
+C L+CP+ F+P+SEN + +SCG P P+ + + +S C +A IKQ+A
Sbjct: 429 SCFLSCPAHTLFVPDSENSYVLSCGVPGPQGKALQKRNGTSSGLGPSCSDAPTTPIKQKA 488
Query: 484 SFKIKDAKCRLHLRNKGKTEEAGRITGPGGAPCSECQVTFIHLKCDSSRKGKGRRARTPP 543
FKI+DAKC L ++ + +E R C VTF+ LKCDSS+ K RR R P
Sbjct: 489 RFKIRDAKCHLRPHSQARAKETAR-----QPLLDHCHVTFVTLKCDSSK--KRRRGRKSP 541
Query: 544 GKEVTRLTLELEAEVRAEETTASCGLPCLRQRMERRLKGSLKMLRKSINQDRFLLRLAGL 603
KEV+ +T E E E + EE + +C CLR+R E+ L+ ++K LRKSI + +F ++++G
Sbjct: 542 SKEVSHITAEFEIETKMEEASDTCEADCLRKRAEQSLQAAIKTLRKSIGRQQFYVQVSGT 601
Query: 604 DYELAHKPGLVAGERAEPMESCRPGQHRAGTKCVSCPQGTYYHGQTEQCVPCPAGTFQER 663
+YE+A +P + E +C GQ +KCV+C GT++ G+ QCV C GT+Q+
Sbjct: 602 EYEVAQRP----AKALEGQGACGAGQVLQDSKCVACGPGTHFGGELGQCVSCMPGTYQDM 657
Query: 664 EGQLSCDLCPGSDAHGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPRGTYQPEAGRTLC 723
EGQLSC CP SD G GA NV+ C GQC PG S DGFKPCQ CP GTYQPE GRT C
Sbjct: 658 EGQLSCTPCPSSDGLGLPGARNVSECGGQCSPGFFSADGFKPCQACPVGTYQPEPGRTGC 717
Query: 724 FPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAMGSYQPDFRQNFCSRCP 783
FPCGGGL TKHEG SFQDC+ KV CSPGH+YNT+ HRCIRC +G+YQP+F QN C CP
Sbjct: 718 FPCGGGLLTKHEGTTSFQDCEAKVHCSPGHHYNTTTHRCIRCPVGTYQPEFGQNHCITCP 777
Query: 784 GNTSTDFDGSTSVAQCKNRQCGGELGEFTGYIESPNYPGNYPAGVECIWNINPPPKRKIL 843
GNTSTDFDGST+V CKN+ CGGELG++TGYIESPNYPG+YPA EC+W+I PPPKR+IL
Sbjct: 778 GNTSTDFDGSTNVTHCKNQHCGGELGDYTGYIESPNYPGDYPANAECVWHIAPPPKRRIL 837
Query: 844 IVVPEIFLPSEDECGDVLVMRKNSSPSSITTYETCQTYERPIAFTARSRKLWINFKTSEA 903
IVVPEIFLP EDECGDVLVMRK++SP+SITTYETCQTYERPIAFT+RSRKLWI FK++E
Sbjct: 838 IVVPEIFLPIEDECGDVLVMRKSASPTSITTYETCQTYERPIAFTSRSRKLWIQFKSNEG 897
Query: 904 NSARGFQIPYVTYDEDYEQLVEDIVRDGRLYASENHQEILKDKKLIKAFFEVLAHPQNYF 963
NS +GFQ+PYVTYDEDY+QL+EDIVRDGRLYASENHQEILKDKKLIKA F+VLAHPQNYF
Sbjct: 898 NSGKGFQVPYVTYDEDYQQLIEDIVRDGRLYASENHQEILKDKKLIKALFDVLAHPQNYF 957
Query: 964 KYT-EKHKEMLPKSFIKLLRSKVSSFLRPYK 993
KYT ++ KEM P+SFIKLLRSKVS FLRPYK
Sbjct: 958 KYTAQESKEMFPRSFIKLLRSKVSRFLRPYK 988
>gi|10190748 CEGP1 protein [Homo sapiens]
Length = 999
Score = 1294 bits (3349), Expect = 0.0
Identities = 596/1022 (58%), Positives = 732/1022 (71%), Gaps = 78/1022 (7%)
Query: 6 VPGLCLLVLLVHARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDG 65
+P L LL V + + +DVDEC +G D+CH DA+CQNTP SYKC CK GY G+G
Sbjct: 22 LPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEG 81
Query: 66 KHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQ 125
+ C+D+DEC E N GCVHDC+NIPGNYRCTC+DGF LAHDGHNCLDVDEC E NGGCQ
Sbjct: 82 RQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQH 141
Query: 126 SCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECR 185
+CVN+MGSYEC C+EGFFLSDNQHTCI R EEG++CMNK+HGC+HIC+E P+G +ACECR
Sbjct: 142 TCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECR 201
Query: 186 PGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIE------- 238
PGFEL KNQRDC LTCN+GNGGCQH+CDDT GP C CH ++ +HTDG++C+E
Sbjct: 202 PGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLE 261
Query: 239 -----------------------TCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTC 275
TCAVNNGGCD C D +TGVHC+CPVGF LQ D KTC
Sbjct: 262 VTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTC 321
Query: 276 KDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNT 335
KDIDEC+ NGGCDH C+N VGSF+C CKKG+KLL +E++CQD+DECS DRTCDH C+N
Sbjct: 322 KDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINH 381
Query: 336 PGSFQCLCHRGYLLYGITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGK 395
PG+F C C+RGY LYG THCGD +ECSIN GGC+ C+NT GSY+C C G +LHWN K
Sbjct: 382 PGTFACACNRGYTLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGY-KLHWNKK 440
Query: 396 DCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPSRARFLPESENGFTVSCGTPSPRAA 455
DC E + + + L C +SG D C L C
Sbjct: 441 DCVEVKGLLPTSVSPRVSLHCGKSGGGDGCFLRC-------------------------- 474
Query: 456 PARAGHNGNSTNSNHCHEAAVLSIKQRASFKIKDAKCRLHLRNKGKTEEAGRITGPGGAP 515
H+G +S+ V +I+ +FK+ + KC L +N E R P
Sbjct: 475 -----HSGIHLSSD------VTTIRTSVTFKLNEGKCSL--KNAELFPEGLRPALPEKHS 521
Query: 516 CSECQVTFIHLKCDSSRKGKGRRARTPPGKEVTRLTLELEAEVRAEETTASCGLPCLRQR 575
+ +++L C S ++ G R KE+ +T+E E E +E TASC L C+ +R
Sbjct: 522 SVKESFRYVNLTCSSGKQVPGAPGRPSTPKEMF-ITVEFELETNQKEVTASCDLSCIVKR 580
Query: 576 MERRLKGSLKMLRKSINQDRFLLRLAGLDYELAHKPGLVAGERAEPMESCRPGQHRAGTK 635
E+RL+ +++ LRK++++++F L+L+G++ ++A KP + +AE SC GQ A +
Sbjct: 581 TEKRLRKAIRTLRKAVHREQFHLQLSGMNLDVAKKPPRTSERQAE---SCGVGQGHAENQ 637
Query: 636 CVSCPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGSDAHGPLG---ATNVTTCAGQ 692
CVSC GTYY G E+C+ CP GTFQ EGQ++C+ CP G L A N++ C G
Sbjct: 638 CVSCRAGTYYDGARERCILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGL 697
Query: 693 CPPGQHSVDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAISFQDCDTKVQCSPG 752
C PG++S DGF PCQ C GT+QPEAGRT CFPCGGGL TKH+GA SFQDC+T+VQCSPG
Sbjct: 698 CQPGEYSADGFAPCQLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSPG 757
Query: 753 HYYNTSIHRCIRCAMGSYQPDFRQNFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEFT 812
H+YNT+ HRCIRC +G+YQP+F +N C CPGNT+TDFDGST++ QCKNR+CGGELG+FT
Sbjct: 758 HFYNTTTHRCIRCPVGTYQPEFGKNNCVSCPGNTTTDFDGSTNITQCKNRRCGGELGDFT 817
Query: 813 GYIESPNYPGNYPAGVECIWNINPPPKRKILIVVPEIFLPSEDECGDVLVMRKNSSPSSI 872
GYIESPNYPGNYPA EC W INPPPKR+ILIVVPEIFLP ED+CGD LVMRK SS +S+
Sbjct: 818 GYIESPNYPGNYPANTECTWTINPPPKRRILIVVPEIFLPIEDDCGDYLVMRKTSSSNSV 877
Query: 873 TTYETCQTYERPIAFTARSRKLWINFKTSEANSARGFQIPYVTYDEDYEQLVEDIVRDGR 932
TTYETCQTYERPIAFT+RS+KLWI FK++E NSARGFQ+PYVTYDEDY++L+EDIVRDGR
Sbjct: 878 TTYETCQTYERPIAFTSRSKKLWIQFKSNEGNSARGFQVPYVTYDEDYQELIEDIVRDGR 937
Query: 933 LYASENHQEILKDKKLIKAFFEVLAHPQNYFKYT-EKHKEMLPKSFIKLLRSKVSSFLRP 991
LYASENHQEILKDKKLIKA F+VLAHPQNYFKYT ++ +EM P+SFI+LLRSKVS FLRP
Sbjct: 938 LYASENHQEILKDKKLIKALFDVLAHPQNYFKYTAQESREMFPRSFIRLLRSKVSRFLRP 997
Query: 992 YK 993
YK
Sbjct: 998 YK 999
>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
Length = 937
Score = 273 bits (697), Expect = 8e-73
Identities = 141/370 (38%), Positives = 191/370 (51%), Gaps = 17/370 (4%)
Query: 46 CQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHL 103
C N P SY C CK GY D C+ D C ED+ C CVN+PG++ C CY G+ L
Sbjct: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDH-NCEQLCVNVPGSFVCQCYSGYAL 311
Query: 104 AHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMN 163
A DG C+ VD CA N GC+ CVN GSY C C EGF L+ ++ TC + C +
Sbjct: 312 AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID----YCAS 367
Query: 164 KNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT--CNYGNGGCQHTCDDTEQGPRC 221
NHGC H C T +C C GF L +++ C+ C GC+H C + E+ C
Sbjct: 368 SNHGCQHECVNT-DDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYC 426
Query: 222 GCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDID 279
CH + L +GKTC ++ CA + GC+ C + C C GF++ D KTC +D
Sbjct: 427 RCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVD 486
Query: 280 ECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSF-DRTCDHICVNTPGS 338
C L++ GC++ C N SF C C +G+ L + + C +D C+ D C+H CV++ S
Sbjct: 487 YCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDS 546
Query: 339 FQCLCHRGYLLY--GITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKD 396
F C C GY+L G T C D C GC C+N+ SY C C G RL +GK
Sbjct: 547 FVCQCFEGYILREDGKT-CRRKDVCQAIDHGCEHICVNSDDSYTCECLEG-FRLAEDGKR 604
Query: 397 CTEPLKCQGS 406
C C+ +
Sbjct: 605 CRRKDVCKST 614
Score = 258 bits (659), Expect = 2e-68
Identities = 141/382 (36%), Positives = 186/382 (48%), Gaps = 24/382 (6%)
Query: 31 DECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAGCVHDCVN 88
D C NC + +C N P S+ C C SGY DGK C VD C E N GC H+CVN
Sbjct: 281 DLCAMEDHNC--EQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASE-NHGCEHECVN 337
Query: 89 IPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQ 148
G+Y C C++GF L D C +D CA N GCQ CVN SY CHC +GF L+ ++
Sbjct: 338 ADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDK 397
Query: 149 HTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT--CNYGNG 206
TC C GC H C + C C G+ L N + C C +
Sbjct: 398 KTC----RRINYCALNKPGCEHECVNMEE-SYYCRCHRGYTLDPNGKTCSRVDHCAQQDH 452
Query: 207 GCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAATGVHCTCPV 264
GC+ C +TE C C F+++ D KTC ++ C +++ GC+ C + C CP
Sbjct: 453 GCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPE 512
Query: 265 GFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDEC-S 323
G +L+ D KTC +D C L + GC+H C ++ SF C C +GY L + + C+ D C +
Sbjct: 513 GHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQA 572
Query: 324 FDRTCDHICVNTPGSFQCLCHRGY-LLYGITHCGDVDECSINRGGCRFGCINTPGSYQCT 382
D C+HICVN+ S+ C C G+ L C D C GC C+N SY C
Sbjct: 573 IDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICK 632
Query: 383 CPAG-----QGRLHWNGKDCTE 399
C G GR K CTE
Sbjct: 633 CSEGFVLAEDGR---RCKKCTE 651
Score = 235 bits (600), Expect = 1e-61
Identities = 122/332 (36%), Positives = 170/332 (51%), Gaps = 18/332 (5%)
Query: 82 CVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREG 141
C H C+NIPG+Y C C G+ L D C D CA + C+Q CVN+ GS+ C C G
Sbjct: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSG 308
Query: 142 FFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT- 200
+ L+++ C+ C ++NHGC H C G C+C GF L +++ C
Sbjct: 309 YALAEDGKRCVAVD----YCASENHGCEHEC-VNADGSYLCQCHEGFALNPDKKTCTKID 363
Query: 201 -CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAATG 257
C N GCQH C +T+ C C F L+ D KTC I CA+N GC+ +C +
Sbjct: 364 YCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEES 423
Query: 258 VHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINE--RN 315
+C C G+ L P+ KTC +D C + GC+ +C NT SF C C +G+ LINE +
Sbjct: 424 YYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGF--LINEDLKT 481
Query: 316 CQDIDECSF-DRTCDHICVNTPGSFQCLCHRGYLLY--GITHCGDVDECSINRGGCRFGC 372
C +D C D C++ CVN SF C C G++L G T C +D C++ GC C
Sbjct: 482 CSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKT-CAKLDSCALGDHGCEHSC 540
Query: 373 INTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQ 404
+++ S+ C C G L +GK C CQ
Sbjct: 541 VSSEDSFVCQCFEGY-ILREDGKTCRRKDVCQ 571
Score = 216 bits (550), Expect = 8e-56
Identities = 110/311 (35%), Positives = 160/311 (51%), Gaps = 13/311 (4%)
Query: 116 CAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRET 175
C+ C C+N+ GSY C C++G+ L+ +Q TC R ++ C ++H C +C
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC--RIQD--LCAMEDHNCEQLCVNV 297
Query: 176 PKGGIACECRPGFELTKNQRDCKLT--CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDG 233
P G C+C G+ L ++ + C C N GC+H C + + C CH F L+ D
Sbjct: 298 P-GSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDK 356
Query: 234 KTC--IETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHI 291
KTC I+ CA +N GC +C + C C GF L PD+KTC+ I+ C LN GC+H
Sbjct: 357 KTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE 416
Query: 292 CRNTVGSFECSCKKGYKLLINERNCQDIDECS-FDRTCDHICVNTPGSFQCLCHRGYLL- 349
C N S+ C C +GY L N + C +D C+ D C+ +C+NT SF C C G+L+
Sbjct: 417 CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLIN 476
Query: 350 YGITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQ-GSPG 408
+ C VD C ++ GC + C+N S+ C CP G L +GK C + C G G
Sbjct: 477 EDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGH-VLRSDGKTCAKLDSCALGDHG 535
Query: 409 ASKAMLSCNRS 419
+ +S S
Sbjct: 536 CEHSCVSSEDS 546
Score = 202 bits (513), Expect = 2e-51
Identities = 104/307 (33%), Positives = 155/307 (50%), Gaps = 14/307 (4%)
Query: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAGC 82
K +D C C + C NT SY C C G+T D K C+ ++ C + GC
Sbjct: 357 KTCTKIDYCASSNHGCQHE--CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCAL-NKPGC 413
Query: 83 VHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGF 142
H+CVN+ +Y C C+ G+ L +G C VD CA+ + GC+Q C+N S+ C C EGF
Sbjct: 414 EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGF 473
Query: 143 FLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC-KL-T 200
++++ TC + C+ +HGC + C + AC+C G L + + C KL +
Sbjct: 474 LINEDLKTCSRVDY----CLLSDHGCEYSCVNMDRS-FACQCPEGHVLRSDGKTCAKLDS 528
Query: 201 CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCI--ETCAVNNGGCDSKCHDAATGV 258
C G+ GC+H+C +E C C ++L DGKTC + C + GC+ C ++
Sbjct: 529 CALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSY 588
Query: 259 HCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQD 318
C C GF L D K C+ D C+ + GC+HIC N S+ C C +G+ L + R C+
Sbjct: 589 TCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKK 648
Query: 319 IDECSFD 325
E D
Sbjct: 649 CTEGPID 655
Score = 114 bits (285), Expect = 5e-25
Identities = 67/219 (30%), Positives = 97/219 (44%), Gaps = 13/219 (5%)
Query: 240 CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSF 299
C+ C C + C C G++L D+ TC+ D C + + C+ +C N GSF
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSF 301
Query: 300 ECSCKKGYKLLINERNCQDIDEC-SFDRTCDHICVNTPGSFQCLCHRGYLLY-GITHCGD 357
C C GY L + + C +D C S + C+H CVN GS+ C CH G+ L C
Sbjct: 302 VCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTK 361
Query: 358 VDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQ-GSPGASKAMLS- 415
+D C+ + GC+ C+NT SY C C G L+ + K C C PG ++
Sbjct: 362 IDYCASSNHGCQHECVNTDDSYSCHCLKG-FTLNPDKKTCRRINYCALNKPGCEHECVNM 420
Query: 416 -------CNRSGKKDTCALTCPSRARFLPESENGFTVSC 447
C+R D TC SR + ++G C
Sbjct: 421 EESYYCRCHRGYTLDPNGKTC-SRVDHCAQQDHGCEQLC 458
>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
Length = 956
Score = 273 bits (697), Expect = 8e-73
Identities = 141/370 (38%), Positives = 191/370 (51%), Gaps = 17/370 (4%)
Query: 46 CQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHL 103
C N P SY C CK GY D C+ D C ED+ C CVN+PG++ C CY G+ L
Sbjct: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDH-NCEQLCVNVPGSFVCQCYSGYAL 311
Query: 104 AHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMN 163
A DG C+ VD CA N GC+ CVN GSY C C EGF L+ ++ TC + C +
Sbjct: 312 AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID----YCAS 367
Query: 164 KNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT--CNYGNGGCQHTCDDTEQGPRC 221
NHGC H C T +C C GF L +++ C+ C GC+H C + E+ C
Sbjct: 368 SNHGCQHECVNT-DDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYC 426
Query: 222 GCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDID 279
CH + L +GKTC ++ CA + GC+ C + C C GF++ D KTC +D
Sbjct: 427 RCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVD 486
Query: 280 ECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSF-DRTCDHICVNTPGS 338
C L++ GC++ C N SF C C +G+ L + + C +D C+ D C+H CV++ S
Sbjct: 487 YCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDS 546
Query: 339 FQCLCHRGYLLY--GITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKD 396
F C C GY+L G T C D C GC C+N+ SY C C G RL +GK
Sbjct: 547 FVCQCFEGYILREDGKT-CRRKDVCQAIDHGCEHICVNSDDSYTCECLEG-FRLAEDGKR 604
Query: 397 CTEPLKCQGS 406
C C+ +
Sbjct: 605 CRRKDVCKST 614
Score = 258 bits (659), Expect = 2e-68
Identities = 141/382 (36%), Positives = 186/382 (48%), Gaps = 24/382 (6%)
Query: 31 DECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAGCVHDCVN 88
D C NC + +C N P S+ C C SGY DGK C VD C E N GC H+CVN
Sbjct: 281 DLCAMEDHNC--EQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASE-NHGCEHECVN 337
Query: 89 IPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQ 148
G+Y C C++GF L D C +D CA N GCQ CVN SY CHC +GF L+ ++
Sbjct: 338 ADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDK 397
Query: 149 HTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT--CNYGNG 206
TC C GC H C + C C G+ L N + C C +
Sbjct: 398 KTC----RRINYCALNKPGCEHECVNMEE-SYYCRCHRGYTLDPNGKTCSRVDHCAQQDH 452
Query: 207 GCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAATGVHCTCPV 264
GC+ C +TE C C F+++ D KTC ++ C +++ GC+ C + C CP
Sbjct: 453 GCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPE 512
Query: 265 GFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDEC-S 323
G +L+ D KTC +D C L + GC+H C ++ SF C C +GY L + + C+ D C +
Sbjct: 513 GHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQA 572
Query: 324 FDRTCDHICVNTPGSFQCLCHRGY-LLYGITHCGDVDECSINRGGCRFGCINTPGSYQCT 382
D C+HICVN+ S+ C C G+ L C D C GC C+N SY C
Sbjct: 573 IDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICK 632
Query: 383 CPAG-----QGRLHWNGKDCTE 399
C G GR K CTE
Sbjct: 633 CSEGFVLAEDGR---RCKKCTE 651
Score = 235 bits (600), Expect = 1e-61
Identities = 122/332 (36%), Positives = 170/332 (51%), Gaps = 18/332 (5%)
Query: 82 CVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREG 141
C H C+NIPG+Y C C G+ L D C D CA + C+Q CVN+ GS+ C C G
Sbjct: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSG 308
Query: 142 FFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT- 200
+ L+++ C+ C ++NHGC H C G C+C GF L +++ C
Sbjct: 309 YALAEDGKRCVAVD----YCASENHGCEHEC-VNADGSYLCQCHEGFALNPDKKTCTKID 363
Query: 201 -CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAATG 257
C N GCQH C +T+ C C F L+ D KTC I CA+N GC+ +C +
Sbjct: 364 YCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEES 423
Query: 258 VHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINE--RN 315
+C C G+ L P+ KTC +D C + GC+ +C NT SF C C +G+ LINE +
Sbjct: 424 YYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGF--LINEDLKT 481
Query: 316 CQDIDECSF-DRTCDHICVNTPGSFQCLCHRGYLLY--GITHCGDVDECSINRGGCRFGC 372
C +D C D C++ CVN SF C C G++L G T C +D C++ GC C
Sbjct: 482 CSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKT-CAKLDSCALGDHGCEHSC 540
Query: 373 INTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQ 404
+++ S+ C C G L +GK C CQ
Sbjct: 541 VSSEDSFVCQCFEGY-ILREDGKTCRRKDVCQ 571
Score = 216 bits (550), Expect = 8e-56
Identities = 110/311 (35%), Positives = 160/311 (51%), Gaps = 13/311 (4%)
Query: 116 CAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRET 175
C+ C C+N+ GSY C C++G+ L+ +Q TC R ++ C ++H C +C
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC--RIQD--LCAMEDHNCEQLCVNV 297
Query: 176 PKGGIACECRPGFELTKNQRDCKLT--CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDG 233
P G C+C G+ L ++ + C C N GC+H C + + C CH F L+ D
Sbjct: 298 P-GSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDK 356
Query: 234 KTC--IETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHI 291
KTC I+ CA +N GC +C + C C GF L PD+KTC+ I+ C LN GC+H
Sbjct: 357 KTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE 416
Query: 292 CRNTVGSFECSCKKGYKLLINERNCQDIDECS-FDRTCDHICVNTPGSFQCLCHRGYLL- 349
C N S+ C C +GY L N + C +D C+ D C+ +C+NT SF C C G+L+
Sbjct: 417 CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLIN 476
Query: 350 YGITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQ-GSPG 408
+ C VD C ++ GC + C+N S+ C CP G L +GK C + C G G
Sbjct: 477 EDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGH-VLRSDGKTCAKLDSCALGDHG 535
Query: 409 ASKAMLSCNRS 419
+ +S S
Sbjct: 536 CEHSCVSSEDS 546
Score = 202 bits (513), Expect = 2e-51
Identities = 104/307 (33%), Positives = 155/307 (50%), Gaps = 14/307 (4%)
Query: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAGC 82
K +D C C + C NT SY C C G+T D K C+ ++ C + GC
Sbjct: 357 KTCTKIDYCASSNHGCQHE--CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCAL-NKPGC 413
Query: 83 VHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGF 142
H+CVN+ +Y C C+ G+ L +G C VD CA+ + GC+Q C+N S+ C C EGF
Sbjct: 414 EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGF 473
Query: 143 FLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC-KL-T 200
++++ TC + C+ +HGC + C + AC+C G L + + C KL +
Sbjct: 474 LINEDLKTCSRVDY----CLLSDHGCEYSCVNMDRS-FACQCPEGHVLRSDGKTCAKLDS 528
Query: 201 CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCI--ETCAVNNGGCDSKCHDAATGV 258
C G+ GC+H+C +E C C ++L DGKTC + C + GC+ C ++
Sbjct: 529 CALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSY 588
Query: 259 HCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQD 318
C C GF L D K C+ D C+ + GC+HIC N S+ C C +G+ L + R C+
Sbjct: 589 TCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKK 648
Query: 319 IDECSFD 325
E D
Sbjct: 649 CTEGPID 655
Score = 114 bits (285), Expect = 5e-25
Identities = 67/219 (30%), Positives = 97/219 (44%), Gaps = 13/219 (5%)
Query: 240 CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSF 299
C+ C C + C C G++L D+ TC+ D C + + C+ +C N GSF
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSF 301
Query: 300 ECSCKKGYKLLINERNCQDIDEC-SFDRTCDHICVNTPGSFQCLCHRGYLLY-GITHCGD 357
C C GY L + + C +D C S + C+H CVN GS+ C CH G+ L C
Sbjct: 302 VCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTK 361
Query: 358 VDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQ-GSPGASKAMLS- 415
+D C+ + GC+ C+NT SY C C G L+ + K C C PG ++
Sbjct: 362 IDYCASSNHGCQHECVNTDDSYSCHCLKG-FTLNPDKKTCRRINYCALNKPGCEHECVNM 420
Query: 416 -------CNRSGKKDTCALTCPSRARFLPESENGFTVSC 447
C+R D TC SR + ++G C
Sbjct: 421 EESYYCRCHRGYTLDPNGKTC-SRVDHCAQQDHGCEQLC 458
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 244 bits (622), Expect = 4e-64
Identities = 126/329 (38%), Positives = 167/329 (50%), Gaps = 21/329 (6%)
Query: 82 CVHDCVNIPGNYR-CTCYDGFHLAHDGHNC-LDVDECAEGNGGCQQSCVNMMGSYECHCR 139
C H +PG+ + C C GF G C DVDEC NGGCQ CVN GSY C C+
Sbjct: 133 CFHGGRCVPGSAQPCHCPPGFQ----GPRCQYDVDECRTHNGGCQHRCVNTPGSYLCECK 188
Query: 140 EGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC-- 197
GF L + TC+ +C N GC H C + C+CRPGF+L ++ R C
Sbjct: 189 PGFRLHTDSRTCLAIN----SCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVR 244
Query: 198 KLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAA 255
+ C NG C H C RC CH+ + L DGK C ++ CA C C +
Sbjct: 245 RSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQ 304
Query: 256 TGVHCTCPVGFMLQPDRKTCKDID-----ECRLNNGGCDHICRNTVGSFECSCKKGYKLL 310
C C G+ L D + C I+ C NNGGC H C +T C+C +GY+L
Sbjct: 305 GSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELD 364
Query: 311 INERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGI-THCGDVDECSINRGGCR 369
++R C D+D+C+ C +C N PG ++C C+ GY L C DVDEC+ +RGGC
Sbjct: 365 TDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCE 424
Query: 370 FGCINTPGSYQCTCPAGQGRLHWNGKDCT 398
C N GS+QC+C AG RLH + + C+
Sbjct: 425 HHCTNLAGSFQCSCEAGY-RLHEDRRGCS 452
Score = 232 bits (591), Expect = 1e-60
Identities = 222/834 (26%), Positives = 293/834 (35%), Gaps = 180/834 (21%)
Query: 55 CICKSGYTGDGKHCK-DVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDV 113
C C G+ G C+ DVDEC R N GC H CVN PG+Y C C GF L D CL +
Sbjct: 147 CHCPPGF--QGPRCQYDVDEC-RTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAI 203
Query: 114 DECAEGNGGCQQSCVNM-MGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHIC 172
+ CA GNGGCQ CV + + + C CR GF L ++ C++R C N+N C H C
Sbjct: 204 NSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSP----CANRNGSCMHRC 259
Query: 173 RETPKGGIACECRPGFELTKNQRDCKLT--CNYGNGGCQHTCDDTEQGPRCGCHIKFVLH 230
+ +G CEC G++L + + C+ C G C H C +T+ +C CH + L
Sbjct: 260 -QVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELG 318
Query: 231 TDGKTC-------IETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTC-------- 275
DG+ C + +C NNGGC C + G CTCP G+ L D++TC
Sbjct: 319 ADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCAD 378
Query: 276 --------------------------------KDIDECRLNNGGCDHICRNTVGSFECSC 303
+D+DEC + GGC+H C N GSF+CSC
Sbjct: 379 SPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSC 438
Query: 304 KKGYKLLINERNCQDID--------ECSFDRTCDHICV---NTPGSFQ----------CL 342
+ GY+L + R C ++ E F R HI V P FQ
Sbjct: 439 EAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAE 498
Query: 343 CHRGYLLYGITHCGDVD---ECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTE 399
+ L C D +CS+ CR G G C CP G W G
Sbjct: 499 LRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEG-----WTG----- 548
Query: 400 PLKCQGSPGASKAMLSCNRSGKKDTCALTCPSRARFLPESENGFTVSCGTPSPRAAPARA 459
L CN + DT C F +NG T T + R P +
Sbjct: 549 --------------LICNETCPPDTFGKNC----SFSCSCQNGGTCDSVTGACRCPPGVS 590
Query: 460 GHN-----GNSTNSNHCHEAAVLSIKQRASFKIKDAKCRLHLRNKGKTEEAGRITGPG-- 512
G N HC + + + R C + G +T P
Sbjct: 591 GTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLC-----DPGLYGRFCHLTCPPWA 645
Query: 513 -GAPCS-ECQVTFIHLKCDSSRKGKGRRARTPPGKEVTRLTLELEAEVRAEETTASCGLP 570
G CS ECQ H + R G + +A R E A C L
Sbjct: 646 FGPGCSEECQCVQPHTQSCDKRDG----------------SCSCKAGFRGERCQAECELG 689
Query: 571 CLRQRMERRLKGSLKMLRKSINQDRFLLRLAGLDYELAHKPGLVAGERAEPMESCRPG-- 628
+ + + S++ + AG E + V SC G
Sbjct: 690 YFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGA 749
Query: 629 ------------QHRAGTKC-VSCPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGS 675
R G C CP+G + G E C C + CD P +
Sbjct: 750 PCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPAC--------QHAARCD--PET 799
Query: 676 DAHGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPRGTYQPEAGRTLC------FPCGGG 729
A L + C CP G + C G P G C F C
Sbjct: 800 GACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRA 859
Query: 730 LTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAMGSYQPDFRQNFCSRCP 783
T H G DC CS GH +I C G P Q +CP
Sbjct: 860 CDTGHWG----PDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQ----QCP 905
Score = 138 bits (347), Expect = 3e-32
Identities = 136/496 (27%), Positives = 189/496 (38%), Gaps = 96/496 (19%)
Query: 6 VPGLCLLVLLVHARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--G 63
V GL V + A KA +DVDEC G C C NT S+KC+C +GY
Sbjct: 262 VRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHG--CLNTQGSFKCVCHAGYELGA 319
Query: 64 DGKHC-----KDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAE 118
DG+ C + V+ CE +N GC H C + CTC G+ L D C+DVD+CA+
Sbjct: 320 DGRQCYRIEMEIVNSCE-ANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCAD 378
Query: 119 GNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKG 178
+ CQQ C N G YEC C G+ LS + C E+ C + GC H C G
Sbjct: 379 -SPCCQQVCTNNPGGYECGCYAGYRLSADGCGC----EDVDECASSRGGCEHHCTNL-AG 432
Query: 179 GIACECRPGFELTKNQRDC----------------------------KLTCNYGNGGCQH 210
C C G+ L +++R C +L + +
Sbjct: 433 SFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQD---DD 489
Query: 211 TCDDTEQGPRCGCHI---KFVL------HTDGKTCIE-----TCAVNNGGCDSKCHDAAT 256
D E+ G H KFV H TC + TC + GCD C + T
Sbjct: 490 VGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCD--CPEGWT 547
Query: 257 GVHC--TCPVGFMLQPDR--KTCKDIDECRLNNGGCDHI---CRNTVGSFECSCKKGYKL 309
G+ C TCP PD K C C+ N G CD + CR G +C+ G
Sbjct: 548 GLICNETCP------PDTFGKNCSFSCSCQ-NGGTCDSVTGACRCPPGVSGTNCEDGCPK 600
Query: 310 LINERNCQDIDECSFDRTCDHI---CVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRG 366
++C+ C+ C + C+ PG + CH + G +EC +
Sbjct: 601 GYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGP-GCSEECQCVQP 659
Query: 367 GCRFGCINTPGSYQCTCPAG--------QGRLHWNGKDCTEPLKCQGSPGASKAMLSCNR 418
+ C GS C+C AG + L + G C + C C +
Sbjct: 660 HTQ-SCDKRDGS--CSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVSGECGK 716
Query: 419 ----SGKKDTCALTCP 430
+ + C CP
Sbjct: 717 RCPAGFQGEDCGQECP 732
Score = 98.6 bits (244), Expect = 3e-20
Identities = 211/890 (23%), Positives = 270/890 (30%), Gaps = 205/890 (23%)
Query: 31 DECVEGT--DNCHIDAICQNTPRSYK----CICKSGYTGD-----------GKHCKDVDE 73
D C +G +C C N R ++ C+C G G G C + +
Sbjct: 596 DGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQ 655
Query: 74 CEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMG- 132
C + C + C+C GF G C E GC Q+C +G
Sbjct: 656 CVQPHTQSCDKR------DGSCSCKAGFR----GERCQAECELGYFGPGCWQACTCPVGV 705
Query: 133 -----SYEC--HCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIA--CE 183
S EC C GF D C Q G +N + C+ C P G+ C
Sbjct: 706 ACDSVSGECGKRCPAGFQGED----CGQECPVGTFGVNCSSSCS--CGGAPCHGVTGQCR 759
Query: 184 CRPGFELTKNQRDCKLTCNYGNGG--CQHTCDDTEQGPRCG-------CHIKFVLHTDGK 234
C PG + DC+ C G G CQ C + RC C FV G
Sbjct: 760 CPPG----RTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFV----GS 811
Query: 235 TCIETCAVNNGG--CDSKCHDA-------ATGVHCTCP---VGFMLQPDRKT------CK 276
C + C G C ++C A ATG HC+C GF Q T C
Sbjct: 812 RCQDVCPAGWYGPSCQTRCSCANDGHCHPATG-HCSCAPGWTGFSCQRACDTGHWGPDCS 870
Query: 277 DIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNC---------QDIDECSFDRT 327
C +G CD I S C C+ GY E+ C + +C
Sbjct: 871 HPCNCSAGHGSCDAI------SGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAA 924
Query: 328 CDHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGCRFGCINTPGSY------QC 381
CDH+ S C C G+ T C CR C T G+ C
Sbjct: 925 CDHV------SGACTCPAGWRG---TFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSC 975
Query: 382 TCPAGQGR--------LHWNGKDCTEPLKCQGSPGASKA--MLSCNRSGKKDTCALTCPS 431
CPAG+ H G +C++ C C +C CP+
Sbjct: 976 LCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPA 1035
Query: 432 -----RARFLPESENGFTVS-----CGTPS------------PRAAPARAGHNGNSTNSN 469
R +NG T C P PR A H+G N
Sbjct: 1036 GLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGG 1095
Query: 470 HC--HEAAVLSIKQRASFKIKDAKCRLHLRNKGKTEEAGRITGPGGAPCSECQVTFIHLK 527
C H L K + + C LR A R + P GA C +
Sbjct: 1096 LCDPHTGRCLCPAGWTGDKCQ-SPC---LRGWFGEACAQRCSCPPGAACHHVTGA---CR 1148
Query: 528 CDSSRKGKGRRARTPPGK--EVTRLTLELEAEVRA---EETTASC-----GLPCLRQRME 577
C G G PPG E + E A T SC G C ++
Sbjct: 1149 CPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPP 1208
Query: 578 RRLKGSLKMLRKSINQD---------RFLLRLAGLDYELA-----------HKPGLVAGE 617
R + L +N R G D L H G G
Sbjct: 1209 GRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGA 1268
Query: 618 RAEPMES---CRPGQHRAGTKCV-SCPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCP 673
+P+ C PG RAG +C CPQ + G C G G SC L
Sbjct: 1269 ACDPVTGTCLCPPG--RAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNGSCSCGL-- 1324
Query: 674 GSDAHGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTK 733
G T C CPPG++ C T +P G C P G +
Sbjct: 1325 --------GWTG-RHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACE 1375
Query: 734 HEGAISFQ--DCDTKVQCSPGHYYNTSIHRCIRCAMGSYQPDFRQNFCSR 781
H F C C G + RC+ C G F +FC R
Sbjct: 1376 HPCPPGFHGAGCQGLCWCQHGAPCDPISGRCL-CPAG-----FHGHFCER 1419
Score = 72.8 bits (177), Expect = 2e-12
Identities = 111/456 (24%), Positives = 147/456 (32%), Gaps = 111/456 (24%)
Query: 28 QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGD-----------GKHCKDVDECER 76
+DV + C +C P + +C+C +G+TGD G+ C C
Sbjct: 1079 RDVRAGCRHSGGCLNGGLCD--PHTGRCLCPAGWTGDKCQSPCLRGWFGEAC--AQRCSC 1134
Query: 77 EDNAGCVH---DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGS 133
A C H C PG C G +C + +C N C + +
Sbjct: 1135 PPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPA------T 1188
Query: 134 YECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGI-----ACECRPGF 188
C C G+ + +C QR G GC +C G AC C GF
Sbjct: 1189 GTCSCAAGY----HGPSCQQRCPPG----RYGPGCEQLCGCLNGGSCDAATGACRCPTGF 1240
Query: 189 ELTKNQRDCKLTCNYGNGG--CQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGG 246
T DC LTC G G C H C QG C D T C G
Sbjct: 1241 LGT----DCNLTCPQGRFGPNCTHVCG-CGQGAAC----------DPVTGTCLCPPGRAG 1285
Query: 247 --CDSKCHDAATGVHC--TCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECS 302
C+ C GV C TC +C++ C +NG C T E +
Sbjct: 1286 VRCERGCPQNRFGVGCEHTC-----------SCRNGGLCHASNGSCSCGLGWTGRHCELA 1334
Query: 303 CKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITH-CGDVDEC 361
C G C C + TC+ P + C C G+ H C
Sbjct: 1335 CPPGRYGAACHLECS----CHNNSTCE------PATGTCRCGPGFYGQACEHPCPPGFHG 1384
Query: 362 SINRG--GCRFGCINTPGSYQCTCPAGQGRLHWN-----------GKDCTEPLKCQGS-- 406
+ +G C+ G P S +C CPAG H + G+ C + C G
Sbjct: 1385 AGCQGLCWCQHGAPCDPISGRCLCPAG---FHGHFCERGCEPGSFGEGCHQRCDCDGGAP 1441
Query: 407 -----------PGASKAM--LSCNRSGKKDTCALTC 429
PG S A L C R +C L C
Sbjct: 1442 CDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHC 1477
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 235 bits (600), Expect = 1e-61
Identities = 145/405 (35%), Positives = 191/405 (47%), Gaps = 30/405 (7%)
Query: 28 QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDG--KHCKDVDECEREDNAGCVHD 85
+DV+EC C C+NT S+ C C G+ D ++C D+DEC +
Sbjct: 985 KDVNECKVFPGLC-THGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGT 1043
Query: 86 CVNIPGNYRCTCYDGFHLAHD-GHNCLDVDECAEGNGGCQ-QSCVNMMGSYECHCREGFF 143
CVN PG++ C C+ G+ NC+DVDECA C+ +C N GSY+C C G
Sbjct: 1044 CVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHE 1103
Query: 144 LSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCK--LTC 201
L+ C E+ C + C H G C C GF+ T +++ C C
Sbjct: 1104 LTAKGTAC----EDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINEC 1159
Query: 202 NYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCD-SKCHDAATGV 258
NGGC C +TE RC C + L DG+ C ++ C N CD C + G
Sbjct: 1160 RVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGH 1219
Query: 259 HCTCPVGFMLQPDRKTCKDIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKLLINERNCQ 317
C C GFM PD +TC D+DEC LN C H C NT GSF C C+ GY + C
Sbjct: 1220 RCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCS 1279
Query: 318 DIDECSF-DRTCDH--ICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGC--RFGC 372
D+DEC CD C+N PGSF C C G++ G C D+DEC C R C
Sbjct: 1280 DVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGF-ECHDLDECVSQEHRCSPRGDC 1338
Query: 373 INTPGSYQCTCP---AGQGRLHWNGKDCTEPL------KCQGSPG 408
+N PGSY+CTC AG G + +C E + +C +PG
Sbjct: 1339 LNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPG 1383
Score = 219 bits (559), Expect = 8e-57
Identities = 138/416 (33%), Positives = 184/416 (44%), Gaps = 66/416 (15%)
Query: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGC 82
K DVDEC C C NT SYKC C G+ T G C+D+DEC D C
Sbjct: 1067 KNCMDVDECARDPLLCR-GGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGL-C 1124
Query: 83 VH-DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREG 141
H CVN+ G ++C+C+ GF D C+D++EC NGGC C+N GSY C C +G
Sbjct: 1125 PHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQG 1184
Query: 142 FFLSDNQHTC--IQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKL 199
+ L + C + EE ++ H C P GG C C GF T + R C
Sbjct: 1185 YSLMPDGRACADVDECEENPRVCDQGH-----CTNMP-GGHRCLCYDGFMATPDMRTCVD 1238
Query: 200 T--CNYGNGGCQH-TCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDS----- 249
C+ C H C++T+ C C + +++ C ++ C V CDS
Sbjct: 1239 VDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCL 1298
Query: 250 -------------------KCHDAATGV-------------------HCTCPVGFMLQPD 271
+CHD V CTC GF D
Sbjct: 1299 NIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGF--AGD 1356
Query: 272 RKTCKDIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDH 330
C+D DEC N CD+ C N G + C C+ G+ + R CQD+DEC+ C
Sbjct: 1357 GFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAF 1416
Query: 331 -ICVNTPGSFQCLCHRGYLL-YGITHCGDVDECSINRGGCRFGCINTPGSYQCTCP 384
C N PG F+C+C+ GY L G +C D++EC+ CINTPGSY C+CP
Sbjct: 1417 GSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCP 1472
Score = 206 bits (525), Expect = 7e-53
Identities = 229/829 (27%), Positives = 307/829 (37%), Gaps = 124/829 (14%)
Query: 28 QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGK-HCKDVDECEREDNAGCVH-D 85
Q +D C T+ C ++ C TP SY+C C GYT D + C DVDEC ++ C H D
Sbjct: 407 QTIDICRHFTNLC-LNGRCLPTPSSYRCECNVGYTQDVRGECIDVDEC---TSSPCHHGD 462
Query: 86 CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFL 144
CVNIPG Y C CY GF C+DVDEC G C CVN GS++C C GF L
Sbjct: 463 CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFEL 522
Query: 145 SDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCK--LTCN 202
S + C+ E + M N C + G +C C+PGF L C C
Sbjct: 523 SPDGKNCVDHNECATSTMCVNGVCLN-----EDGSFSCLCKPGFLLAPGGHYCMDIDECQ 577
Query: 203 YGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIE-----TC--AVNNGGCDSKCHDAA 255
C +TE RC C + TDG+ C++ TC A+ G C
Sbjct: 578 TPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTV 637
Query: 256 TGVHCTC---PVGF----MLQPDRKTC----------------KDIDECRLNNGGC-DHI 291
T C C GF L P + + +DI+EC L+ C + +
Sbjct: 638 TKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGV 697
Query: 292 CRNTVGSFECSCKKGYKLLINERNCQDIDECSFDR-TCDH-ICVNTPGSFQCLCHRGYLL 349
C N GS+ C C GY+ + ++C D+DEC+ + CD+ C N+PGS+ C C G+
Sbjct: 698 CENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHF 757
Query: 350 YGITH-CGDVDECSINRGGCRFG-CINTPGSYQCTCPAGQGRLHWNGKDCTEPLK--CQG 405
+ T C DVDEC C G C N GSY C C G RL +G C + K C
Sbjct: 758 WQDTEICKDVDECL--SSPCVSGVCRNLAGSYTCKCGPG-SRLDPSGTFCLDSTKGTCWL 814
Query: 406 SPGASKAMLSCNRSGKKDTCALTCPS-------RARFLPESENGFT----VSCGTPSPRA 454
S+ ++ + + C T + R P GF V+C +
Sbjct: 815 KIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECE 874
Query: 455 APARAGHNGNSTNSN-----HCHEAAVLSIKQRASFKIKDAKCRLHLRNKGKTEEAGRIT 509
+ NG N+ C E +L R ++ C L + +E G +T
Sbjct: 875 SFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFL----RWDEDECG-VT 929
Query: 510 GPGGAPCSECQVTFIHLKCDSSRKGKGRRARTPPGKEVTRLTLELEAEVRAEETTASCGL 569
PG C C S G P E + G
Sbjct: 930 LPGKYRMDVC--------CCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGR 981
Query: 570 PCLRQRMERRLKGSLKMLRKSINQDRFLLRLAGLDYELAHKPGLVAGER-AEPMESCRPG 628
P + E ++ L N + A L A ER ++ CR
Sbjct: 982 PFYKDVNECKVFPGLCTHGTCRN------TVGSFHCACAGGFALDAQERNCTDIDECRIS 1035
Query: 629 QHRAGT-KCVSCPQGTYYHGQTE-QCVPCPAGTFQEREGQLSCDLCPGSDAHGPL---GA 683
G CV+ P G E +C P F + + D C A PL G
Sbjct: 1036 PDLCGQGTCVNTP------GSFECECFPGYESGFMLMKNCMDVDEC----ARDPLLCRGG 1085
Query: 684 TNVTTCAG---QCPPGQHSVDGFKPCQP----------CPRGTYQPEAGRTLCFPCGGGL 730
T T QCPPG C+ CP G G C C G
Sbjct: 1086 TCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQC-SCHAGF 1144
Query: 731 --TTKHEGAISFQDCDTKVQCSPGHYYNT-SIHRCIRCAMG-SYQPDFR 775
T +G + +C + H NT +RC C G S PD R
Sbjct: 1145 QSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRC-SCGQGYSLMPDGR 1192
Score = 197 bits (500), Expect = 5e-50
Identities = 147/437 (33%), Positives = 187/437 (42%), Gaps = 53/437 (12%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGC-VHD 85
D+DEC C + C+N SY C+C G+ T +G C D DEC C
Sbjct: 1847 DIDEC--DRQPCG-NGTCKNIIGSYNCLCFPGFVVTHNGD-CVDFDECTTLVGQVCRFGH 1902
Query: 86 CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGC-QQSCVNMMGSYECHCREGFFL 144
C+N G++ C C DGF L DG NC+D +EC G C +C N+ GS+ C C GF +
Sbjct: 1903 CLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQV 1962
Query: 145 SDNQHTCIQRPEEGMNCMNKNHGCAH-ICRETPKGGIACECRPGFELTKNQRDCKLTCNY 203
+ CI E C + + C C +P G C C PGF L+ N
Sbjct: 1963 QSDH--CIDIDE----CSEEPNLCLFGTCTNSP-GSFQCLCPPGFVLSDN---------- 2005
Query: 204 GNGGCQHTCDDTEQG------PRCGCHIKFVLHTDGKTCIETCAVNNG-----GCDSKCH 252
H C DT Q C + +T C C+ G C+
Sbjct: 2006 -----GHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRC--CCSKRPGEGWGDPCELCPQ 2058
Query: 253 DAATGVHCTCPVGFMLQPDRKTCK-DIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKLL 310
+ + CP G P + D++EC N G C + +C NT GSF C C GY L
Sbjct: 2059 EGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLD 2118
Query: 311 INERNCQDIDECSFDRTCDH-ICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGCR 369
NC D DECS C C N G F+C C G+ + C D+DECS+N C
Sbjct: 2119 FTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCA 2178
Query: 370 FGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKC-QGSPGASKAMLSC-NRSGKKDTCAL 427
F C NT GSY CTCPAG L +G C + +C G + C N G T A
Sbjct: 2179 FRCHNTEGSYLCTCPAGY-TLREDGAMCRDVDECADGQQDCHARGMECKNLIG---TFAC 2234
Query: 428 TCPSRARFLPESENGFT 444
CP R LP S G T
Sbjct: 2235 VCPPGMRPLPGSGEGCT 2251
Score = 193 bits (491), Expect = 6e-49
Identities = 147/452 (32%), Positives = 190/452 (42%), Gaps = 88/452 (19%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGD--GKHCKDV--DECER---EDNAG 81
DV+EC C + C NT S++C C G D G+ C DV + C ED G
Sbjct: 869 DVNECESFPGVCP-NGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECG 927
Query: 82 CVHDCVNIPGNYR---CTCYDGFHLAHDGHNC---------------------------- 110
V +PG YR C C G + C
Sbjct: 928 -----VTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRP 982
Query: 111 --LDVDECAEGNGGCQQ-SCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHG 167
DV+EC G C +C N +GS+ C C GF L + C E C
Sbjct: 983 FYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDE----CRISPDL 1038
Query: 168 CAH-ICRETPKGGIACECRPGFE----LTKNQRDCK------LTCNYGNGGCQHTCDDTE 216
C C TP G CEC PG+E L KN D L C G TC +T+
Sbjct: 1039 CGQGTCVNTP-GSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGG------TCTNTD 1091
Query: 217 QGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCD-SKCHDAATGVHCTCPVGFMLQPDRK 273
+C C L G C I+ C++++G C +C + C+C GF PDR+
Sbjct: 1092 GSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQ 1151
Query: 274 TCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFD-RTCDH-I 331
C DI+ECR+ NGGCD C NT GS+ CSC +GY L+ + R C D+DEC + R CD
Sbjct: 1152 GCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGH 1211
Query: 332 CVNTPGSFQCLCHRGYLLY-GITHCGDVDECSINRGGCRFG-CINTPGSYQCTCPAGQ-- 387
C N PG +CLC+ G++ + C DVDEC +N C G C NT GS+ C C G
Sbjct: 1212 CTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMV 1271
Query: 388 ----------GRLHWNGKDCTEPLKCQGSPGA 409
G +C C PG+
Sbjct: 1272 RKGATGCSDVDECEVGGHNCDSHASCLNIPGS 1303
Score = 189 bits (479), Expect = 1e-47
Identities = 139/475 (29%), Positives = 204/475 (42%), Gaps = 77/475 (16%)
Query: 19 RAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECER 76
+A +A DVDEC+ CH+ C NT S++C+C +G+ + DGK+C D +EC
Sbjct: 479 QATPTRQACVDVDECIVSGGLCHLGR-CVNTEGSFQCVCNAGFELSPDGKNCVDHNEC-- 535
Query: 77 EDNAGCVHD-CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYE 135
+ CV+ C+N G++ C C GF LA GH C+D+DEC C N GS+
Sbjct: 536 ATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFR 595
Query: 136 CHCREGFFLSDNQHTCIQ-----------------RPEEG------MNCMNKNHGCAHIC 172
C C G + + C+ RP G C N +HG C
Sbjct: 596 CQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPC 655
Query: 173 RETPKGGIA---CECRPGFELTKNQRDCKLTCNYGNGGCQH-TCDDTEQGPRCGCHIKFV 228
+ P A C G +T + RD C C + C++ RC C++ +
Sbjct: 656 QLCPAKDSAEFQALCSSGLGITTDGRDIN-ECALDPEVCANGVCENLRGSYRCVCNLGYE 714
Query: 229 LHTDGKTC--IETCAVNNGGCDSK-CHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNN 285
GK C ++ CA+N+ CD+ C ++ C+CP GF D + CKD+DEC L++
Sbjct: 715 AGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDEC-LSS 773
Query: 286 GGCDHICRNTVGSFECSCKKGYK-----------------LLINERNCQ-DIDECSFDRT 327
+CRN GS+ C C G + L I E C+ ++ S
Sbjct: 774 PCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSE 833
Query: 328 CDHICVNTPGS------FQCLCHRGYL-LYGITHCGDVDECSINRGGCRFG-CINTPGSY 379
C GS C RG+ + G+T C DV+EC G C G C+NT GS+
Sbjct: 834 CCATLGAAWGSPCERCEIDPACARGFARMTGVT-CDDVNECESFPGVCPNGRCVNTAGSF 892
Query: 380 QCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPSRAR 434
+C CP G L +G+ C + + C +D C +T P + R
Sbjct: 893 RCECPEGL-MLDASGRLCVD-----------VRLEPCFLRWDEDECGVTLPGKYR 935
Score = 185 bits (469), Expect = 2e-46
Identities = 131/377 (34%), Positives = 164/377 (43%), Gaps = 24/377 (6%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVN 88
D+DECV C C N P SY+C C+ G+ GDG C+D DEC + C+N
Sbjct: 1321 DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN 1380
Query: 89 IPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQ 148
PG YRC C GF D C DVDECA+GN SC N+ G + C C G+ L
Sbjct: 1381 APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG 1440
Query: 149 HTC--IQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNG 206
C I + +NC+N +C TP G C C FEL + C T G
Sbjct: 1441 GNCTDINECADPVNCIN------GVCINTP-GSYLCSCPQDFELNPSGVGCVDT---RAG 1490
Query: 207 GC-QHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVG 265
C T D + G C I V T C C+ T CP G
Sbjct: 1491 NCFLETHDRGDSGISCSAEIG-VGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGG 1549
Query: 266 FMLQPDRKT--CKDIDECRLNNGGCD-HICRNTVGSFECSCKKGYKLLINERNCQDIDEC 322
QP+R T +DIDEC+ G C C NT GSF+C C GY L + R C+DIDEC
Sbjct: 1550 EGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDEC 1609
Query: 323 S-FDRTC-DHICVNTPGSFQCLCHRGYL-LYGITHCGDVDECSINR---GGCRFGCINTP 376
S C C NT G++ C+C YL + G +C D+ + R G C+
Sbjct: 1610 STHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNV 1669
Query: 377 GSYQCTCPAGQGRLHWN 393
C C G+ WN
Sbjct: 1670 TRKMCCCSYNIGQA-WN 1685
Score = 185 bits (469), Expect = 2e-46
Identities = 107/314 (34%), Positives = 148/314 (47%), Gaps = 21/314 (6%)
Query: 52 SYKCICK--SGYTGDGKHCKDVDECEREDNAGCVH-DCVNIPGNYRCTCYDGFHLAHDGH 108
+Y+ +C SGYT +G+ DVDEC + C H +C+N G++RC C G+
Sbjct: 2346 AYRKLCPHGSGYTAEGR---DVDECRMLAHL-CAHGECINSLGSFRCHCQAGYTPDATAT 2401
Query: 109 NCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGC 168
CLD+DEC++ C C N GS+ C C G+ L ++ TC E C ++ H C
Sbjct: 2402 TCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDE----CTSRQHNC 2457
Query: 169 AHICRETPKGGIACECRPGFELTKNQRDC----KLTCNYGNGGCQHTCDDTEQGPRCGCH 224
+C T G C C PGF T++ + C + + G G C +T RC CH
Sbjct: 2458 QFLCVNT-VGAFTCRCPPGF--TQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECH 2514
Query: 225 IKFVLHTDGKTCIETCAVNN-GGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRL 283
F L + G C + + C C + G C+CP GF C D +EC L
Sbjct: 2515 QGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECAL 2574
Query: 284 NNGGCDHI-CRNTVGSFECSCKKGYKLLINERNCQDIDECSFDR-TCDHICVNTPGSFQC 341
+ C CRNT+G F C C G+ CQ++DEC+ R C + C NTPG F C
Sbjct: 2575 SPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLC 2634
Query: 342 LCHRGYLLYGITHC 355
C +GY G HC
Sbjct: 2635 GCPQGYFRAGQGHC 2648
Score = 182 bits (462), Expect = 1e-45
Identities = 128/420 (30%), Positives = 181/420 (43%), Gaps = 44/420 (10%)
Query: 28 QDVDECVEGTDNCHIDAI-CQNTPRSYKCICKSGYT---GDGKHCKDVDECEREDNAGCV 83
+DVDEC +G +CH + C+N ++ C+C G G G+ C D +EC + +
Sbjct: 2206 RDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVN 2265
Query: 84 HDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGS------YECH 137
CVN G++RC C +GF + C D+ + Q C ++ S EC
Sbjct: 2266 GRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECC 2325
Query: 138 CREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC 197
C G C P G + K C H T +G ECR L
Sbjct: 2326 CGGGRGWGPRCELC---PLPGTSAYRKL--CPHGSGYTAEGRDVDECRMLAHL------- 2373
Query: 198 KLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCI--ETCAVNNGGCDSKCHDAA 255
C +G C ++ RC C + TC+ + C+ C C +
Sbjct: 2374 ---CAHGE------CINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTK 2424
Query: 256 TGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERN 315
C+CP G++L+ D +TCKD+DEC C +C NTVG+F C C G+ + +
Sbjct: 2425 GSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQ--HHQA 2482
Query: 316 CQDIDECSFDR---TCDHICVNTPGSFQCLCHRGYLLYGITH-CGDVDECSINRGGCRFG 371
C D DECS C NTPGSF+C CH+G+ L H C DV+EC C+ G
Sbjct: 2483 CFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECD-GPHRCQHG 2541
Query: 372 CINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPS 431
C N G Y+C+CP G + H C + +C SP + SC + C CPS
Sbjct: 2542 CQNQLGGYRCSCPQGFTQ-HSQWAQCVDENECALSP-PTCGSASCRNTLGGFRC--VCPS 2597
Score = 179 bits (455), Expect = 9e-45
Identities = 121/376 (32%), Positives = 166/376 (44%), Gaps = 32/376 (8%)
Query: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVH 84
K D +EC+ C + CQN S++CIC G+ HC D+DEC E N
Sbjct: 1925 KNCVDTNECLSLAGTC-LPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFG 1983
Query: 85 DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFL 144
C N PG+++C C GF L+ +GH C D Q C + +C + F
Sbjct: 1984 TCTNSPGSFQCLCPPGFVLSDNGHRCFDTR---------QSFCFTRFEAGKCSVPKAFNT 2034
Query: 145 SDNQHTCIQRPEEGMN--C-MNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTC 201
+ + C +RP EG C + G A P G A PG + R+ C
Sbjct: 2035 TKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAV---PG---PDDSREDVNEC 2088
Query: 202 NYGNGGCQH-TCDDTEQGPRCGCHIKFVLHTDGKTCIET--CAVNNGGCDSKCHDAATGV 258
G C + C +T+ RC C + L G C++T C+V + C + G
Sbjct: 2089 AENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGF 2148
Query: 259 HCTCPVGFMLQPD-RKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQ 317
C C GF +P TC+DIDEC LN C C NT GS+ C+C GY L + C+
Sbjct: 2149 ECACADGF--EPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCR 2206
Query: 318 DIDECSFDRTCDHI----CVNTPGSFQCLCHRGY--LLYGITHCGDVDECSINRGGCRFG 371
D+DEC+ + H C N G+F C+C G L C D +EC C G
Sbjct: 2207 DVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNG 2266
Query: 372 -CINTPGSYQCTCPAG 386
C+NT GS++C C G
Sbjct: 2267 RCVNTAGSFRCDCDEG 2282
Score = 172 bits (437), Expect = 1e-42
Identities = 142/429 (33%), Positives = 188/429 (43%), Gaps = 73/429 (17%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDG--KHCKDVDEC-EREDNAGCVHD 85
D+DEC E C + IC N S++C C +G+ + C+DVDEC RE D
Sbjct: 1721 DIDECGEIPAIC-ANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNAD 1779
Query: 86 CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQ-SCVNMMGSYECHCREGFFL 144
C+NIPG+YRC C G+ L+ G C+ +EC E C C++ GSY C C GF
Sbjct: 1780 CINIPGSYRCKCTRGYKLS-PGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQA 1838
Query: 145 SDNQHTCIQRPE-EGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC------ 197
S +Q C+ E + C N C +I G C C PGF +T N DC
Sbjct: 1839 SADQTLCMDIDECDRQPCGNGT--CKNII-----GSYNCLCFPGFVVTHN-GDCVDFDEC 1890
Query: 198 ----KLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIET--CAVNNGGC-DSK 250
C +G+ C +T C C F L DGK C++T C G C
Sbjct: 1891 TTLVGQVCRFGH------CLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGT 1944
Query: 251 CHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGC-DHICRNTVGSFECSCKKGYKL 309
C + C CP GF +Q D C DIDEC C C N+ GSF+C C G+ L
Sbjct: 1945 CQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVL 2002
Query: 310 LINERNCQD-----------IDECS----FDRTCDHICVN-TPG---------------- 337
N C D +CS F+ T C + PG
Sbjct: 2003 SDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSA 2062
Query: 338 SFQCLCHRGY-LLYGITHC-GDVDECSINRGGCRFG-CINTPGSYQCTCPAGQGRLHWNG 394
+FQ LC G+ + G DV+EC+ N G C G C+NT GS++C CP G L + G
Sbjct: 2063 AFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYS-LDFTG 2121
Query: 395 KDCTEPLKC 403
+C + +C
Sbjct: 2122 INCVDTDEC 2130
Score = 144 bits (362), Expect = 5e-34
Identities = 109/393 (27%), Positives = 158/393 (40%), Gaps = 69/393 (17%)
Query: 69 KDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQ-SC 127
+D+DEC+ DCVN G+++C C G+HL+ C D+DEC+ +G C +C
Sbjct: 1562 EDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGTC 1621
Query: 128 VNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPG 187
N +G+Y C C + + G NCM+ +C G C+
Sbjct: 1622 YNTLGNYTCVCPAEYLQVNG----------GNNCMDMRKS---VCFRHYNG--TCQNELA 1666
Query: 188 FELTKNQRDCKLTCNYG-NGGCQH--TCDDTEQGPRCGCHIKFVL---HTDGKTCIETCA 241
F +T+ C N C+ T + CG L HT I+ C
Sbjct: 1667 FNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECG 1726
Query: 242 VNNGGC-DSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDEC------------------- 281
C + C + C CP GF C+D+DEC
Sbjct: 1727 EIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGS 1786
Query: 282 ---------RLNNGG--------------CDH-ICRNTVGSFECSCKKGYKLLINERNCQ 317
+L+ GG C H C +T GS+ C C +G++ ++ C
Sbjct: 1787 YRCKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCM 1846
Query: 318 DIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGG-CRFG-CINT 375
DIDEC + C N GS+ CLC G+++ C D DEC+ G CRFG C+NT
Sbjct: 1847 DIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNT 1906
Query: 376 PGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPG 408
GS+ C C G L +GK+C + +C G
Sbjct: 1907 AGSFHCLCQDG-FELTADGKNCVDTNECLSLAG 1938
Score = 133 bits (335), Expect = 7e-31
Identities = 112/368 (30%), Positives = 149/368 (40%), Gaps = 60/368 (16%)
Query: 68 CKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECA----EGNGGC 123
C+DVDEC+ CVN+ G++ C C G L+ C D A G C
Sbjct: 245 CQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRC 304
Query: 124 QQSCVNMMGSYECHCREGFF--------------LSDNQHTCIQR----PEE-------- 157
+C C G ++ Q C QR P
Sbjct: 305 AGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLL 364
Query: 158 --GMNCMNKNHGCAHICRETPKGGIA---CECRPGFELTKNQRDCKLTCNYGNGGCQH-- 210
G N M G A R P G A PG N T N C+H
Sbjct: 365 GFGSNGMGPPLGPA---RLNPHGSDARGIPSLGPG-----NSNIGTATLNQTIDICRHFT 416
Query: 211 ------TCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGC-DSKCHDAATGVHCTCP 263
C T RC C++ + G+ CI+ + C C + HC C
Sbjct: 417 NLCLNGRCLPTPSSYRCECNVGYTQDVRGE-CIDVDECTSSPCHHGDCVNIPGTYHCRCY 475
Query: 264 VGFMLQPDRKTCKDIDECRLNNGGCDHI--CRNTVGSFECSCKKGYKLLINERNCQDIDE 321
GF P R+ C D+DEC ++ G C H+ C NT GSF+C C G++L + +NC D +E
Sbjct: 476 PGFQATPTRQACVDVDECIVSGGLC-HLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNE 534
Query: 322 CSFDRTC-DHICVNTPGSFQCLCHRGYLLY-GITHCGDVDECSINRGGCRFG-CINTPGS 378
C+ C + +C+N GSF CLC G+LL G +C D+DEC G C G C NT GS
Sbjct: 535 CATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQ-TPGICVNGHCTNTEGS 593
Query: 379 YQCTCPAG 386
++C C G
Sbjct: 594 FRCQCLGG 601
Score = 128 bits (322), Expect = 2e-29
Identities = 67/202 (33%), Positives = 90/202 (44%), Gaps = 10/202 (4%)
Query: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDN-AGCV 83
+ +D+DEC NC +C NT ++ C C G+T + C D DEC + G
Sbjct: 2442 RTCKDLDECTSRQHNCQF--LCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAH 2499
Query: 84 HDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFF 143
C N PG++RC C+ GF L GH C DV+EC +G CQ C N +G Y C C +GF
Sbjct: 2500 GHCHNTPGSFRCECHQGFTLVSSGHGCEDVNEC-DGPHRCQHGCQNQLGGYRCSCPQGFT 2558
Query: 144 LSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT--C 201
C+ E C C GG C C GF+ + C+ C
Sbjct: 2559 QHSQWAQCVDENE----CALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDEC 2614
Query: 202 NYGNGGCQHTCDDTEQGPRCGC 223
G C ++C +T G CGC
Sbjct: 2615 AGRRGPCSYSCANTPGGFLCGC 2636
Score = 106 bits (264), Expect = 1e-22
Identities = 59/170 (34%), Positives = 77/170 (45%), Gaps = 10/170 (5%)
Query: 22 QYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDN 79
Q+ +A D DEC C C NTP S++C C G+T G C+DV+EC+
Sbjct: 2478 QHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHR 2537
Query: 80 AGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGC-QQSCVNMMGSYECHC 138
C H C N G YRC+C GF C+D +ECA C SC N +G + C C
Sbjct: 2538 --CQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVC 2595
Query: 139 REGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGF 188
GF C +E C + C++ C TP GG C C G+
Sbjct: 2596 PSGFDFDQALGGC----QEVDECAGRRGPCSYSCANTP-GGFLCGCPQGY 2640
Score = 58.9 bits (141), Expect = 2e-08
Identities = 72/298 (24%), Positives = 96/298 (32%), Gaps = 60/298 (20%)
Query: 74 CEREDNAGCVHDCVNIPGNYRCT-------CYDGFHLAHDGHNCLD---VDECAEGNG-G 122
C +A C PG +C C +GF + C D C G G
Sbjct: 60 CGSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSG 119
Query: 123 CQQSCVN--MMGSYECHCREGFFLSD-NQHTCIQRPEEGMNCMNKNHGCAHICRETPKGG 179
C SC+N C C++G+ + Q C + G C+ N
Sbjct: 120 CSVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNR------------- 166
Query: 180 IACECRPGFELTKNQRDCKLTCNYGN---GGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC 236
C C GF + +RD + +G GCQH G C
Sbjct: 167 --CACVYGFMGPQCERDYRTGPCFGQVGPEGCQH-------------------QLTGLVC 205
Query: 237 IET--CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDH-ICR 293
+ CA C H C GF+ C+D+DEC+ G C C
Sbjct: 206 TKALCCATVGRAWGLPCELCPAQPH-PCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCV 264
Query: 294 NTVGSFECSCKKGYKLLINERNCQDID-----ECSFDRTCDHICVNTPGSFQCLCHRG 346
N VGSF C C G++L + C+D F C QC C RG
Sbjct: 265 NMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRG 322
Score = 52.0 bits (123), Expect = 3e-06
Identities = 65/249 (26%), Positives = 87/249 (34%), Gaps = 69/249 (27%)
Query: 197 CKLTCNYGNGGCQH----TCDDTEQGPRCG------CHIKFVLHTDGKTCIETCAVNNGG 246
C+ C G G C TC D P CG C + + +G TC + G
Sbjct: 86 CRRAC--GEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCM---NGGTCRGASCLCQKG 140
Query: 247 ----------CDSKCHDAATGV---HCTCPVGFMLQPDRKTCKDIDEC--RLNNGGCDH- 290
CD CH+ + C C GFM P + C ++ GC H
Sbjct: 141 YTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFM-GPQCERDYRTGPCFGQVGPEGCQHQ 199
Query: 291 ---------ICRNTVG---SFECS--------CKKGYKLLINERNCQDIDEC-SFDRTCD 329
+C TVG C C++G+ I+ CQD+DEC + C
Sbjct: 200 LTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQ 259
Query: 330 H-ICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGCRFGCI-------NTPGSY-- 379
CVN GSF C C G+ L + C R G F + + G Y
Sbjct: 260 GGSCVNMVGSFHCRCPVGHRLSDSSAA-----CEDYRAGACFSVLFGGRCAGDLAGHYTR 314
Query: 380 -QCTCPAGQ 387
QC C G+
Sbjct: 315 RQCCCDRGR 323
Score = 37.4 bits (85), Expect = 0.070
Identities = 51/175 (29%), Positives = 66/175 (37%), Gaps = 31/175 (17%)
Query: 615 AGERAEPMESCRPGQHRAGTKC--------VSCPQGTYYHGQTEQCV----------PCP 656
+G E + C G HR C SCPQG H Q QCV C
Sbjct: 2522 SGHGCEDVNEC-DGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG 2580
Query: 657 AGTFQEREGQLSCDLCP-GSDAHGPL-GATNVTTCAGQCPPGQHS---VDGFKPCQPCPR 711
+ + + G C +CP G D L G V CAG+ P +S G C CP+
Sbjct: 2581 SASCRNTLGGFRC-VCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLC-GCPQ 2638
Query: 712 GTYQPEAGRT---LCFPCGGGLTTKHEGAISFQDC-DTKVQ-CSPGHYYNTSIHR 761
G ++ G L F G T E +S + C + K+ SP S HR
Sbjct: 2639 GYFRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHR 2693
Score = 34.7 bits (78), Expect = 0.46
Identities = 65/285 (22%), Positives = 86/285 (30%), Gaps = 85/285 (29%)
Query: 7 PGLCLLVLLVHARAAQYSKAAQ-DVDECVEGT----------DNCHIDAICQNTPRSYKC 55
PG V+ + RA +Q ++ C +GT C + + T R C
Sbjct: 76 PGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASC 135
Query: 56 ICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDE 115
+C+ GYTG C+R GC H+ G RC C GF G C E
Sbjct: 136 LCQKGYTGT---VCGQPICDR----GC-HNGGRCIGPNRCACVYGFM----GPQC----E 179
Query: 116 CAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRET 175
G C +G C Q G+ C K CA + R
Sbjct: 180 RDYRTG----PCFGQVGPEGC----------------QHQLTGLVC-TKALCCATVGR-- 216
Query: 176 PKGGIACECRPGFELTKNQRDCK--LTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDG 233
G+ CE P C+ N G CQ
Sbjct: 217 -AWGLPCELCPA-----QPHPCRRGFIPNIHTGACQD----------------------- 247
Query: 234 KTCIETCAVNNGGCD-SKCHDAATGVHCTCPVGFMLQPDRKTCKD 277
++ C G C C + HC CPVG L C+D
Sbjct: 248 ---VDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACED 289
Score = 32.3 bits (72), Expect = 2.3
Identities = 22/57 (38%), Positives = 26/57 (45%), Gaps = 8/57 (14%)
Query: 707 QPCPRGTYQPEAG--RTLCFPCGGGLTTKHEG-AISFQDCDTKV--QCSPGHYYNTS 758
QPC GT + G LCFP G H G + F +C T V C GH NT+
Sbjct: 1854 QPCGNGTCKNIIGSYNCLCFP---GFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTA 1907
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 220 bits (560), Expect = 6e-57
Identities = 137/399 (34%), Positives = 195/399 (48%), Gaps = 36/399 (9%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDG---KHCKDVDECEREDNAGCVHD 85
D+DEC D C C NTP ++C C GY K+C D+DEC+R+
Sbjct: 1070 DIDECRISPDLCGRGQ-CVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGV 1128
Query: 86 CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFL 144
C N G+YRC C G L+ + C+D++EC C CVN++G Y+C C G+
Sbjct: 1129 CHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHS 1188
Query: 145 SDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQR------DCK 198
+ ++ C+ E C N GC C + +G C C+PGF L +QR +C+
Sbjct: 1189 TPDRLFCVDIDE----CSIMNGGCETFCTNS-EGSYECSCQPGFALMPDQRSCTDIDECE 1243
Query: 199 LTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIET--CAVNNGGCDS-KCHDAA 255
N +GG C + RC C+ F+ D KTC++ C +N C S C +
Sbjct: 1244 DNPNICDGG---QCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTK 1300
Query: 256 TGVHCTCPVGFMLQPDRKTCKDIDECRL--NNGGCDHICRNTVGSFECSCKKGYKLLINE 313
C C +G+ + + C DI+EC + +N G +C NT GSF+CSC G+ + +
Sbjct: 1301 GSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGW--IGDG 1358
Query: 314 RNCQDIDECSFD-RTCDHI--CVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGCRF 370
C D+DECS C C NT GS++CLC GY G T C D+DECS N C
Sbjct: 1359 IKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFT-CTDLDECSENLNLCGN 1417
Query: 371 G-CINTPGSYQCTC-----PAGQGRLHWNGKDCTEPLKC 403
G C+N PG Y+C C P+ G+ + +C+ P C
Sbjct: 1418 GQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNIC 1456
Score = 218 bits (555), Expect = 2e-56
Identities = 142/405 (35%), Positives = 187/405 (46%), Gaps = 30/405 (7%)
Query: 28 QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDG--KHCKDVDECEREDNAGCVHD 85
+D++EC C C+NT S+KC C SG+ D ++C D+DEC +
Sbjct: 1027 KDINECKMIPSLC-THGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQ 1085
Query: 86 CVNIPGNYRCTCYDGFHLAH-DGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFF 143
CVN PG++ C C +G+ NC+D+DEC C+ C N GSY C C G
Sbjct: 1086 CVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQ 1145
Query: 144 LSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCK--LTC 201
LS N CI E C H C + G C C PG+ T ++ C C
Sbjct: 1146 LSPNISACIDINE----CELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDEC 1201
Query: 202 NYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCD-SKCHDAATGV 258
+ NGGC+ C ++E C C F L D ++C I+ C N CD +C +
Sbjct: 1202 SIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEY 1261
Query: 259 HCTCPVGFMLQPDRKTCKDIDECRLNNGGC-DHICRNTVGSFECSCKKGYKLLINERNCQ 317
C C GFM D KTC D++EC LN C C NT GSF C C GY + C
Sbjct: 1262 RCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCT 1321
Query: 318 DIDECSFD-RTCDH--ICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGC--RFGC 372
DI+EC C +C NT GSF+C C G++ GI C D+DECS C C
Sbjct: 1322 DINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGI-KCTDLDECSNGTHMCSQHADC 1380
Query: 373 INTPGSYQCTCP---AGQGRLHWNGKDCTEPL------KCQGSPG 408
NT GSY+C C G G + +C+E L +C +PG
Sbjct: 1381 KNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPG 1425
Score = 204 bits (520), Expect = 3e-52
Identities = 148/535 (27%), Positives = 212/535 (39%), Gaps = 93/535 (17%)
Query: 28 QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAGCVH- 84
+D++EC + C C NT SY+C C GY D + CKD DECE E C
Sbjct: 2205 EDINECAQNPLLCAFR--CVNTYGSYECKCPVGYVLREDRRMCKDEDECE-EGKHDCTEK 2261
Query: 85 --DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHC--- 138
+C N+ G Y C C G+ DG C+D +EC G C+ C+N GSY C C
Sbjct: 2262 QMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDG 2321
Query: 139 -------------REGFFLSDNQHTCIQRPEEGMNCMNKNHGCAH--------------- 170
REG+ ++ Q N + K+ C
Sbjct: 2322 FTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQ 2381
Query: 171 ------------------------------ICRE----TPKGGIACECRPGFELTKNQRD 196
+CR +G C C+ G+
Sbjct: 2382 GTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTS 2441
Query: 197 CK--LTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSKCH 252
C CN C C +TE +C C ++L DG++C ++ CA C C
Sbjct: 2442 CVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCV 2501
Query: 253 DAATGVHCTCPVGFMLQPDRKTCKDIDECR--LNNGGCDHICRNTVGSFECSCKKGYKLL 310
+ G C CP GF +C D +EC +N G IC+NT GSF C C++G+ L
Sbjct: 2502 NTIGGFTCKCPPGFTQH--HTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLD 2559
Query: 311 INERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLL-YGITHCGDVDECSINRGGCR 369
+C+D+DEC + C H C N G ++C C +GYL Y C D +EC
Sbjct: 2560 QTGSSCEDVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGG 2619
Query: 370 FGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTC 429
C NT GSY+C CPAG ++G C + +C G+++A S S + C
Sbjct: 2620 ASCHNTLGSYKCMCPAGFQYEQFSG-GCQDINEC----GSAQAPCSYGCSNTEGGYLCGC 2674
Query: 430 PSRARFLPESE--NGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEAAVLSIKQR 482
P + + +G + G P P P + NS + C+E + +R
Sbjct: 2675 PPGYFRIGQGHCVSGMGMGRGNPEP---PVSGEMDDNSLSPEACYECKINGYPKR 2726
Score = 203 bits (516), Expect = 7e-52
Identities = 132/421 (31%), Positives = 189/421 (44%), Gaps = 53/421 (12%)
Query: 31 DECVEGTDNCHI-----DAICQNTPRSYKCICKSGYT-GDGKHCKDVDECEREDNAGCVH 84
+ECV+ TD C + + C+N ++C C+ G+ G C+D++EC + C
Sbjct: 2162 NECVD-TDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLL-CAF 2219
Query: 85 DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGC---QQSCVNMMGSYECHCREG 141
CVN G+Y C C G+ L D C D DEC EG C Q C N++G+Y C C G
Sbjct: 2220 RCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPG 2279
Query: 142 FFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC---- 197
+ + C+ E C K C + +G CEC GF + NQ +C
Sbjct: 2280 YQRRPDGEGCVDENE----CQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNR 2335
Query: 198 ---------KLTCNYGNGGCQ-----HTCDDTEQGPRCGCHI----------KFVLHTDG 233
+ C G+ C D +G C I K H G
Sbjct: 2336 EGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRG 2395
Query: 234 KTC----IETCAVNNGGC-DSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGC 288
I+ C V + C + +C + HC C G+ +C D++EC C
Sbjct: 2396 FMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPC 2455
Query: 289 DHICRNTVGSFECSCKKGYKLLINERNCQDIDECSF-DRTCDHICVNTPGSFQCLCHRGY 347
+ IC+NT GS++CSC KGY L + R+C+D+DEC+ C +CVNT G F C C G+
Sbjct: 2456 NFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGF 2515
Query: 348 LLYGITHCGDVDECS--INRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQG 405
+ T C D +EC+ IN G + C NTPGS+ C C G L G C + +C+G
Sbjct: 2516 TQHH-TSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFS-LDQTGSSCEDVDECEG 2573
Query: 406 S 406
+
Sbjct: 2574 N 2574
Score = 198 bits (504), Expect = 2e-50
Identities = 130/375 (34%), Positives = 171/375 (45%), Gaps = 28/375 (7%)
Query: 26 AAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGCV 83
A D++EC C + C N Y+C C GY T D C D+DEC N GC
Sbjct: 1152 ACIDINECELSAHLCP-NGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIM-NGGCE 1209
Query: 84 HDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGF 142
C N G+Y C+C GF L D +C D+DEC + C C N+ G Y C C +GF
Sbjct: 1210 TFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGF 1269
Query: 143 FLSDNQHTCIQRPEEGMNC-MNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCK--L 199
S++ TC+ E C +N N + C T KG C C G+ K + C
Sbjct: 1270 MASEDMKTCVDVNE----CDLNPNICLSGTCENT-KGSFICHCDMGYSGKKGKTGCTDIN 1324
Query: 200 TCNYG--NGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGG--CD--SKCHD 253
C G N G C +T +C C ++ DG C + +NG C + C +
Sbjct: 1325 ECEIGAHNCGKHAVCTNTAGSFKCSCSPGWI--GDGIKCTDLDECSNGTHMCSQHADCKN 1382
Query: 254 AATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKLLIN 312
C C G+ D TC D+DEC N C + C N G + C C G+ +
Sbjct: 1383 TMGSYRCLCKEGYT--GDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSAD 1440
Query: 313 ERNCQDIDECSFDRTCDH-ICVNTPGSFQCLCHRGYLL-YGITHCGDVDECSINRGGCRF 370
+ C+DIDECS C C N PG F+C C GY L +C DV+EC ++ C
Sbjct: 1441 GKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNEC-LDPTTCIS 1499
Query: 371 G-CINTPGSYQCTCP 384
G C+NTPGSY C CP
Sbjct: 1500 GNCVNTPGSYICDCP 1514
Score = 198 bits (503), Expect = 2e-50
Identities = 140/414 (33%), Positives = 184/414 (44%), Gaps = 54/414 (13%)
Query: 17 HARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDEC 74
H ++ DVDEC G N + C NT S++C C GY DG+ C D++EC
Sbjct: 1918 HGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINEC 1977
Query: 75 EREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQ-QSCVNMMGS 133
E C N+ G+YRC C G+ L ++ C D+DEC E C +C N GS
Sbjct: 1978 LLEPRKCAPGTCQNLDGSYRCICPPGYSLQNE--KCEDIDECVEEPEICALGTCSNTEGS 2035
Query: 134 YECHCREGFFLSDNQHTC-------IQRPEEGMNC---MNKNHGCAHICRETPKG---GI 180
++C C EGF LS + C EG C ++NH C KG G
Sbjct: 2036 FKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCAL-KGEGWGD 2094
Query: 181 ACECRPGFELTKNQRDCKLTCNYGNG-------------------GCQH-TCDDTEQGPR 220
CE P T+ + C YG+G C+H C +T+ R
Sbjct: 2095 PCELCP----TEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYR 2150
Query: 221 CGCHIKFVLHTDGKTCIET--CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDI 278
C C ++L G C++T C+V N + C + G CTC GF P TC+DI
Sbjct: 2151 CECPFGYIL--AGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGP-MMTCEDI 2207
Query: 279 DECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDEC---SFDRTCDHI-CVN 334
+EC N C C NT GS+EC C GY L + R C+D DEC D T + C N
Sbjct: 2208 NECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKN 2267
Query: 335 TPGSFQCLCHRGYLLYGITH-CGDVDECSINRGGCRFG-CINTPGSYQCTCPAG 386
G++ C+C GY C D +EC G C G C+NT GSY C C G
Sbjct: 2268 LIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDG 2321
Score = 186 bits (471), Expect = 1e-46
Identities = 135/417 (32%), Positives = 193/417 (46%), Gaps = 80/417 (19%)
Query: 36 GTDNCHIDAICQNTPRSYKCICKSG-------YTGDGKHCKDVDECEREDNAGCVHD-CV 87
GT+ C + +NTP Y+ +C G T KD++EC+ + C H C
Sbjct: 989 GTEECE-ECPMRNTPE-YEELCPRGPGFATKEITNGKPFFKDINECKMIPSL-CTHGKCR 1045
Query: 88 NIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFLSD 146
N G+++C C GF L + NC D+DEC C + CVN G +EC C EG+
Sbjct: 1046 NTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGY---- 1101
Query: 147 NQHTCIQRPEEGM----NCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCN 202
E G NCM+ + EC QRD L C
Sbjct: 1102 ---------ESGFMMMKNCMDID-----------------EC---------QRD-PLLCR 1125
Query: 203 YGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIET--CAVNNGGC-DSKCHDAATGVH 259
G C +TE RC C L + CI+ C ++ C + +C +
Sbjct: 1126 GG------VCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQ 1179
Query: 260 CTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDI 319
C C G+ PDR C DIDEC + NGGC+ C N+ GS+ECSC+ G+ L+ ++R+C DI
Sbjct: 1180 CACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDI 1239
Query: 320 DECSFD-RTCD-HICVNTPGSFQCLCHRGYLL-YGITHCGDVDECSINRGGCRFG-CINT 375
DEC + CD C N PG ++CLC+ G++ + C DV+EC +N C G C NT
Sbjct: 1240 DECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENT 1299
Query: 376 PGSYQCTCPAGQGRLHWNGK----DCTEPLKCQ-GSPGASKAMLSCNRSGK-KDTCA 426
GS+ C C G ++GK CT+ +C+ G+ K + N +G K +C+
Sbjct: 1300 KGSFICHCDMG-----YSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCS 1351
Score = 179 bits (455), Expect = 9e-45
Identities = 134/439 (30%), Positives = 190/439 (43%), Gaps = 57/439 (12%)
Query: 34 VEGTDNCH-IDAICQN-----TPRSYKCICKSGYTGDGK-HCKDVDECEREDNAGCVHDC 86
V TD C + +CQN TP S +C C G+ D + C DVDECE+ AG +C
Sbjct: 447 VNVTDYCQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCAG--GEC 504
Query: 87 VNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFLS 145
+N G+Y C C G+ C D+DEC + C C+N GS+ C C GF ++
Sbjct: 505 INNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVT 564
Query: 146 DNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCK--LTCNY 203
+ C E + M N C + G C C+PGF+L + R CK C
Sbjct: 565 RDGKNCEDMDECSIRNMCLNGMCIN-----EDGSFKCICKPGFQLASDGRYCKDINECET 619
Query: 204 GNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIE-----TC--AVNNGGCDSKCHDAAT 256
C +T+ RC C + DG+ C++ TC G C A T
Sbjct: 620 PGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVT 679
Query: 257 GVHCTC-----PVGFMLQP--------DRKTC----------KDIDECRLNNGGCDH-IC 292
C C G QP + C DI+EC L+ C + IC
Sbjct: 680 KSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGIC 739
Query: 293 RNTVGSFECSCKKGYKLLINERNCQDIDECSFDR-TCDH-ICVNTPGSFQCLCHRGYLLY 350
N G+++C C GY++ +NC DI+EC + CD+ C NTPGSF C C +G++
Sbjct: 740 ENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYK 799
Query: 351 -GITHCGDVDECSINRGGCRFG-CINTPGSYQCTCPAGQGRLHWNGKDCTEPLK--CQGS 406
+ C D+DEC C G C N+PGS+ C C + + L C E +K C +
Sbjct: 800 PDLKTCEDIDEC--ESSPCINGVCKNSPGSFICEC-SSESTLDPTKTICIETIKGTCWQT 856
Query: 407 PGASKAMLSCNRSGKKDTC 425
+ ++ N + K C
Sbjct: 857 VIDGRCEININGATLKSQC 875
Score = 179 bits (454), Expect = 1e-44
Identities = 113/336 (33%), Positives = 151/336 (44%), Gaps = 14/336 (4%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVN 88
D+DEC GT C A C+NT SY+C+CK GYTGDG C D+DEC N C+N
Sbjct: 1363 DLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLN 1422
Query: 89 IPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQ 148
PG YRC C GF + DG C D+DEC+ N +C N+ G + C C G+ L +
Sbjct: 1423 APGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSG 1482
Query: 149 HTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGC 208
C E C++ + C TP G C+C P FEL + C T +G C
Sbjct: 1483 GNCTDVNE----CLDPTTCISGNCVNTP-GSYICDCPPDFELNPTRVGCVDT---RSGNC 1534
Query: 209 QHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATG---VHCTCPVG 265
C + + +C + G C T + C G
Sbjct: 1535 YLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEG 1594
Query: 266 FMLQPDRKTCKDIDECRLNNGGCD-HICRNTVGSFECSCKKGYKLLINERNCQDIDECSF 324
F P +DIDEC+ G C C NT GSF+C C GY L + R C D++EC
Sbjct: 1595 FRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECET 1654
Query: 325 DRTC-DHICVNTPGSFQCLCHRGYL-LYGITHCGDV 358
C C NT G++ C+C Y+ + G +C D+
Sbjct: 1655 PGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDM 1690
Score = 172 bits (437), Expect = 1e-42
Identities = 133/432 (30%), Positives = 195/432 (45%), Gaps = 63/432 (14%)
Query: 23 YSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGK--HCKDVDECEREDNA 80
Y+ D+DEC E C + +C N S++C C G+ + K C+D+DEC+
Sbjct: 1760 YTGLPVDIDECREIPGVCE-NGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVC 1818
Query: 81 GCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQ-SCVNMMGSYECHCR 139
+C+N G+YRC C G+ G C D +EC E C C++ +GS+ C C
Sbjct: 1819 QRNAECINTAGSYRCDCKPGYRFTSTG-QCNDRNECQEIPNICSHGQCIDTVGSFYCLCH 1877
Query: 140 EGFFLSDNQHTCIQRPE-EGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC- 197
GF +D+Q C+ E E C N CR T G C C GF L+ N DC
Sbjct: 1878 TGFKTNDDQTMCLDINECERDACGNGT------CRNT-IGSFNCRCNHGFILSHN-NDCI 1929
Query: 198 -KLTCNYGNGG-CQH-TCDDTEQGPRCGCHIKFVLHTDGKTCIE--TCAVNNGGC-DSKC 251
C GNG C++ C +T +C C+ + + DG+TC++ C + C C
Sbjct: 1930 DVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTC 1989
Query: 252 HDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCD-HICRNTVGSFECSCKKGYKLL 310
+ C CP G+ LQ ++ C+DIDEC C C NT GSF+C C +G+ L
Sbjct: 1990 QNLDGSYRCICPPGYSLQNEK--CEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLS 2047
Query: 311 INERNCQDI-----------DECSFDRTCDH-------------------ICVNTPG-SF 339
+ R CQD+ +CS ++ +H +C P +F
Sbjct: 2048 SSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAF 2107
Query: 340 QCLC--HRGYLLYGITHCGDVDECSINRGGCRFG-CINTPGSYQCTCPAGQGRLHWNGKD 396
+ +C G ++ D+DEC C+ G CINT GSY+C CP G G +
Sbjct: 2108 RQICPYGSGIIVGPDDSAVDMDECK-EPDVCKHGQCINTDGSYRCECPFG---YILAGNE 2163
Query: 397 CTEPLKCQ-GSP 407
C + +C G+P
Sbjct: 2164 CVDTDECSVGNP 2175
Score = 147 bits (372), Expect = 4e-35
Identities = 122/400 (30%), Positives = 166/400 (41%), Gaps = 77/400 (19%)
Query: 69 KDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQ-SC 127
+D+DEC+ C+N G+++C C G++L D C DV+EC E G C +C
Sbjct: 1605 EDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNEC-ETPGICGPGTC 1663
Query: 128 VNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPG 187
N +G+Y C C + + G NCM+ + R C+
Sbjct: 1664 YNTVGNYTCICPPDYMQVNG----------GNNCMDMRRSLCY--RNYYADNQTCDGELL 1711
Query: 188 FELTKNQRDCKLTCNYG---NGGCQHTC--DDTEQGPRCGCHIK-FVL--HTDGKTCIET 239
F +TK C + N G N C+ E CG FV+ +T I+
Sbjct: 1712 FNMTKKM--CCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDE 1769
Query: 240 CAVNNGGCDSK-CHDAATGVHCTCPVGFMLQPDRKTCKDIDECR-----------LNNGG 287
C G C++ C + C CPVGF C+DIDEC+ +N G
Sbjct: 1770 CREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAG 1829
Query: 288 ------------------------------CDH-ICRNTVGSFECSCKKGYKLLINERNC 316
C H C +TVGSF C C G+K ++ C
Sbjct: 1830 SYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMC 1889
Query: 317 QDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGG-CRFG-CIN 374
DI+EC D + C NT GSF C C+ G++L C DVDEC+ G CR G CIN
Sbjct: 1890 LDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCIN 1949
Query: 375 TPGSYQCTCPAG-----QGRLHWNGKDC-TEPLKCQGSPG 408
T GS+QC C G GR + +C EP KC +PG
Sbjct: 1950 TVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKC--APG 1987
Score = 127 bits (319), Expect = 5e-29
Identities = 114/414 (27%), Positives = 165/414 (39%), Gaps = 83/414 (20%)
Query: 46 CQNTPRS----YKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGF 101
CQ P Y+ +C SG G D++EC + + C N+ G Y+C C G+
Sbjct: 696 CQPCPAQNSAEYQALCSSG-PGMTSAGSDINECALDPDICPNGICENLRGTYKCICNSGY 754
Query: 102 HLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFLSDNQHTCIQRPE-EGM 159
+ G NC+D++EC + C C N GS+ C C +GF + TC E E
Sbjct: 755 EVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESS 814
Query: 160 NCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGP 219
C+N +C+ +P G CEC L + C T + TC T
Sbjct: 815 PCING------VCKNSP-GSFICECSSESTLDPTKTICIETI-------KGTCWQTVIDG 860
Query: 220 RCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCT-------CPVGFMLQPDR 272
RC +I +G T C + G AA G CT C G+
Sbjct: 861 RCEINI------NGATLKSQCCSSLG--------AAWGSPCTLCQVDPICGKGYSRIKGT 906
Query: 273 KTCKDIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKLLINERNCQDI-----------D 320
+ C+DIDEC + G C + +C NT GSF+C C G L R C DI +
Sbjct: 907 Q-CEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDE 965
Query: 321 ECSF--------------------DRTCDHICVNTPGSFQCLCHRG------YLLYGITH 354
EC+ C+ + ++ LC RG + G
Sbjct: 966 ECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPF 1025
Query: 355 CGDVDECSINRGGCRFG-CINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSP 407
D++EC + C G C NT GS++C C +G L ++CT+ +C+ SP
Sbjct: 1026 FKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFA-LDSEERNCTDIDECRISP 1078
Score = 115 bits (287), Expect = 3e-25
Identities = 61/169 (36%), Positives = 86/169 (50%), Gaps = 9/169 (5%)
Query: 22 QYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGD--GKHCKDVDECEREDN 79
Q+ + D +EC + C ICQNTP S+ C C+ G++ D G C+DVDEC E N
Sbjct: 2517 QHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDEC--EGN 2574
Query: 80 AGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCR 139
C H C NI G YRC+C G+ + + C+D +EC + SC N +GSY+C C
Sbjct: 2575 HRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHNTLGSYKCMCP 2634
Query: 140 EGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGF 188
GF C ++ C + C++ C T +GG C C PG+
Sbjct: 2635 AGFQYEQFSGGC----QDINECGSAQAPCSYGCSNT-EGGYLCGCPPGY 2678
Score = 114 bits (286), Expect = 3e-25
Identities = 118/479 (24%), Positives = 185/479 (38%), Gaps = 100/479 (20%)
Query: 123 CQQS-CVNMMGSYECHCREGFFLSDNQHTCI------QRPEEGMNCMNKNHGCAHICRET 175
CQ C+ GS C C +GF L D + CI + P G C+N
Sbjct: 460 CQNGRCIPTPGSCRCECNKGFQL-DLRGECIDVDECEKNPCAGGECINN----------- 507
Query: 176 PKGGIACECRPGFELTKNQRDCK---------LTCNYGNGGCQHTCDDTEQGPRCGCHIK 226
+G C+CR G++ T + +C+ CN G C +T+ C C+
Sbjct: 508 -QGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGR------CINTDGSFHCVCNAG 560
Query: 227 FVLHTDGKTC--IETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLN 284
F + DGK C ++ C++ N + C + C C GF L D + CKDI+EC
Sbjct: 561 FHVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETP 620
Query: 285 NGGCDHICRNTVGSF--EC--------------------SCKKGYK----------LLIN 312
+ C NT GS+ EC +C GYK +
Sbjct: 621 GICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTK 680
Query: 313 ERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITHCG-DVDECSINRGGCRFG 371
C E +F C +Q LC G G+T G D++EC+++ C G
Sbjct: 681 SECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGP---GMTSAGSDINECALDPDICPNG 737
Query: 372 -CINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDT---CAL 427
C N G+Y+C C +G + GK+C + +C + L C+ ++T
Sbjct: 738 ICENLRGTYKCICNSGY-EVDSTGKNCVDINECVLNS------LLCDNGQCRNTPGSFVC 790
Query: 428 TCPSRARFLPESENGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEAA-----------V 476
TCP + P+ + + ++P G NS S C ++ +
Sbjct: 791 TCPKGFIYKPDLKTCEDID----ECESSPCINGVCKNSPGSFICECSSESTLDPTKTICI 846
Query: 477 LSIKQRASFKIKDAKCRLHLRNKG-KTEEAGRITGPGGAPCSECQVTFIHLKCDSSRKG 534
+IK + D +C +++ K++ + G+PC+ CQV I K S KG
Sbjct: 847 ETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKG 905
Score = 87.0 bits (214), Expect = 8e-17
Identities = 98/341 (28%), Positives = 129/341 (37%), Gaps = 38/341 (11%)
Query: 63 GDGKH--CKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGN 120
G G H K + C NA C +PG +C H DG C + C +
Sbjct: 46 GGGGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIVPICRHSCGDGF-CSRPNMCTCPS 104
Query: 121 GGCQQSCVNMMGSY-ECHCREGFFLSDNQHTCIQRPEEGMNCMNK--NHGCAHICRETPK 177
G SC + + C G SD+ C Q+ G +C GC + R
Sbjct: 105 GQIAPSCGSRSIQHCNIRCMNGGSCSDDHCLC-QKGYIGTHCGQPVCESGCLNGGRCVAP 163
Query: 178 GGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTE-QGPRCG--CHIKFVLHTDGK 234
C C GF + +RD Y G C + QG G C T G+
Sbjct: 164 N--RCACTYGFTGPQCERD------YRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGR 215
Query: 235 TCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDH-ICR 293
C + C ++ H C GF+ C+D+DEC+ G C C
Sbjct: 216 AWGHPCEM----CPAQPHP--------CRRGFIPNIRTGACQDVDECQAIPGLCQGGNCI 263
Query: 294 NTVGSFECSCKKGYKLLINERNCQDIDECS-FDRTCD-HICVNTPGSFQCLCHRG-YLLY 350
NTVGSFEC C G+KL + C+DIDECS C+ C NT S+ C C G Y
Sbjct: 264 NTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSP 323
Query: 351 GITHCGDVDE----CSINRGGCRFGCINTPGSYQCTCPAGQ 387
T C DV ++ G C + QC C AG+
Sbjct: 324 DGTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCCCDAGR 364
Score = 64.7 bits (156), Expect = 4e-10
Identities = 39/122 (31%), Positives = 54/122 (44%), Gaps = 7/122 (5%)
Query: 26 AAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGD--GKHCKDVDECEREDNAGCV 83
A QDVDEC C C NT S++C C +G+ + + C+D+DEC
Sbjct: 243 ACQDVDECQAIPGLCQ-GGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEG 301
Query: 84 HDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDE----CAEGNGGCQQSCVNMMGSYECHCR 139
+C N +Y C C GF+ + DG C+DV A NG C + +C C
Sbjct: 302 GECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCCCD 361
Query: 140 EG 141
G
Sbjct: 362 AG 363
Score = 50.4 bits (119), Expect = 8e-06
Identities = 55/234 (23%), Positives = 78/234 (33%), Gaps = 47/234 (20%)
Query: 54 KCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDV 113
+C C G+TG +CER+ G C + N C G C
Sbjct: 165 RCACTYGFTGP--------QCERDYRTG---PCFTVISNQMCQGQ------LSGIVCTKT 207
Query: 114 DECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPE--------EGMNCMNKN 165
CA C M + CR GF + C E +G NC+N
Sbjct: 208 LCCATVGRAWGHPC-EMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINT- 265
Query: 166 HGCAHICRETPKGGIACECRPGFELTKNQRDCKLT--CNYGNGGCQH-TCDDTEQGPRCG 222
G C+C G +L + + C+ C+ G C+ C +T C
Sbjct: 266 -----------VGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCK 314
Query: 223 CHIKFVLHTDGKTCIET------CAVNNGGCDSKCHDAATGVHCTCPVGFMLQP 270
C F DG CI+ A+ NG C ++ + T + C C G P
Sbjct: 315 CPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCCCDAGRCWSP 368
Score = 42.4 bits (98), Expect = 0.002
Identities = 62/234 (26%), Positives = 81/234 (34%), Gaps = 54/234 (23%)
Query: 625 CRPG--QHRAGTKCVSCPQGTYYHGQTEQCVP----------CPAGTFQEREGQLSCDLC 672
C PG Q+ G+ CP G Y Q E+C C GT EG C LC
Sbjct: 1984 CAPGTCQNLDGSYRCICPPG--YSLQNEKCEDIDECVEEPEICALGTCSNTEGSFKC-LC 2040
Query: 673 PGSDAHGPLGAT----NVTTC-----AGQCPPGQ---HSV---------DGF-KPCQPCP 710
P + G ++ C G+C + HS +G+ PC+ CP
Sbjct: 2041 PEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCP 2100
Query: 711 RGTYQPEAGRTLCFPCGGGLTT-KHEGAISFQDCDTKVQCSPGHYYNT-SIHRCIRCAMG 768
T EA R +C P G G+ + A+ +C C G NT +RC C G
Sbjct: 2101 --TEPDEAFRQIC-PYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRC-ECPFG 2156
Query: 769 SYQPDFRQNFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEFTGYIESPNYPG 822
GN D D + C N C +G F E PG
Sbjct: 2157 YI-----------LAGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPG 2199
Score = 39.3 bits (90), Expect = 0.019
Identities = 36/125 (28%), Positives = 44/125 (35%), Gaps = 22/125 (17%)
Query: 616 GERAEPMESCRPGQHRAGTKC--------VSCPQGTYYHGQTEQCVPCPAGTFQEREGQL 667
G E ++ C G HR C SCPQG H Q QCV + L
Sbjct: 2562 GSSCEDVDECE-GNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCV--------DENECL 2612
Query: 668 SCDLCPGSDAHGPLGATNVTTCAG----QCPPGQHSVDGFKPCQ-PCPRGTYQPEAGRTL 722
S +C G+ H LG+ AG Q G ++ Q PC G E G
Sbjct: 2613 SAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLC 2672
Query: 723 CFPCG 727
P G
Sbjct: 2673 GCPPG 2677
Score = 33.9 bits (76), Expect = 0.78
Identities = 19/52 (36%), Positives = 25/52 (48%), Gaps = 3/52 (5%)
Query: 22 QYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDV 71
+ S+ +D+DEC C C NT SY C C G+ + DG C DV
Sbjct: 281 EVSQKCEDIDECSTIPGICE-GGECTNTVSSYFCKCPPGFYTSPDGTRCIDV 331
Score = 30.4 bits (67), Expect = 8.6
Identities = 40/166 (24%), Positives = 53/166 (31%), Gaps = 38/166 (22%)
Query: 652 CVPCPAGTFQEREGQLSCDLCPGSDAHGPLGATNVTTCAGQCPP------GQHSVDGFKP 705
C CPA E + LCPG + P T + +C G ++ F
Sbjct: 1574 CEMCPAVNTSEYK-----ILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGS 1628
Query: 706 CQ-PCPRGTYQPEAGRTLCFPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIR 764
Q CP G Y E R +C+T C PG YNT
Sbjct: 1629 FQCRCPTGYYLNEDTRV---------------CDDVNECETPGICGPGTCYNT------- 1666
Query: 765 CAMGSYQPDFRQNFCSRCPGNTSTDFDGSTSVAQ--CKNRQCGGEL 808
+G+Y ++ GN D S N+ C GEL
Sbjct: 1667 --VGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGEL 1710
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 215 bits (547), Expect = 2e-55
Identities = 139/444 (31%), Positives = 188/444 (42%), Gaps = 97/444 (21%)
Query: 28 QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAGCVHD 85
+D++EC + C C NT SY+C C GY D K CKD+DEC A +HD
Sbjct: 2252 EDINECAQNPLLCAFR--CMNTFGSYECTCPIGYALREDQKMCKDLDEC-----AEGLHD 2304
Query: 86 CV-------NIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECH 137
C N+ G + C C G DG C+D +EC G C+ CVN++GSY C
Sbjct: 2305 CESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCE 2364
Query: 138 CREGFFLSDNQHTCI----------------QRPEEGMNCMNKNHGCA-------HICRE 174
C EGF S + C+ Q N + K+ C H C
Sbjct: 2365 CNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCEL 2424
Query: 175 TPKGGIA-----CECRPGFELTKNQRD---CKLTCNYGNGGCQHTCDDTEQGPRCGCHIK 226
P G A C PG+ T + RD CK+ N G C +T RC C +
Sbjct: 2425 CPLPGTAQYKKICPHGPGY--TTDGRDIDECKVMPNLCTNG---QCINTMGSFRCFCKVG 2479
Query: 227 FVLHTDGKTCIET--CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLN 284
+ G +CI+ C+ + C+ C + C+CP G++LQ D KTCKD+DEC+
Sbjct: 2480 YTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTK 2539
Query: 285 NGGCDH-----------------------------------------ICRNTVGSFECSC 303
C IC+NT GSF C C
Sbjct: 2540 QHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCEC 2599
Query: 304 KKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLL-YGITHCGDVDECS 362
++G+ L NC+D+DEC + C H C N G ++C C +GY+ Y C D +ECS
Sbjct: 2600 QRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECS 2659
Query: 363 INRGGCRFGCINTPGSYQCTCPAG 386
C NT GSY+C CP+G
Sbjct: 2660 NPNACGSASCYNTLGSYKCACPSG 2683
Score = 205 bits (522), Expect = 1e-52
Identities = 149/495 (30%), Positives = 210/495 (42%), Gaps = 91/495 (18%)
Query: 28 QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT-GDGKHCKDVDECEREDNAGCVHD- 85
+D+DEC G + C +A C N+P SY+C C +G+ C D +EC N C H
Sbjct: 1849 EDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNV-CSHGL 1907
Query: 86 CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAE---GNGGCQQS---------------- 126
CV++ G+Y+C C++GF + D C+DVDEC GNG C+ +
Sbjct: 1908 CVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTH 1967
Query: 127 ----------------------CVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNK 164
C N +GS++C C EG+ L+ + CI E C+
Sbjct: 1968 NNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNE----CVAL 2023
Query: 165 NHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQH-TCDDTEQGPRCGC 223
C+ + +G C C PG+E+ C+ C +C +T G +C C
Sbjct: 2024 PGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLC 2083
Query: 224 HIKFVLHTDGKTCIET----CAVN--NGGCD---------SKC----------------- 251
FVL +G+ C +T C N NG C +KC
Sbjct: 2084 PPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELC 2143
Query: 252 -HDAATGVHCTCPVGFMLQPD-RKTCKDIDECRLNNGGCDH-ICRNTVGSFECSCKKGYK 308
D CP G P T +D++EC + G C + C NT GSF C C GY
Sbjct: 2144 PKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYN 2203
Query: 309 LLINERNCQDIDECSFDRTCDH-ICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGG 367
L C D DECS C + C N GSF+C C+ G+ + +C D++EC+ N
Sbjct: 2204 LDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLL 2263
Query: 368 CRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGS--PGASKAMLSCNRSGKKDTC 425
C F C+NT GSY+CTCP G L + K C + +C S+ M+ N G T
Sbjct: 2264 CAFRCMNTFGSYECTCPIGYA-LREDQKMCKDLDECAEGLHDCESRGMMCKNLIG---TF 2319
Query: 426 ALTCPSRARFLPESE 440
CP P+ E
Sbjct: 2320 MCICPPGMARRPDGE 2334
Score = 199 bits (506), Expect = 1e-50
Identities = 146/444 (32%), Positives = 195/444 (43%), Gaps = 56/444 (12%)
Query: 28 QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGK-HCKDVDECEREDNAGCVHDC 86
Q +D C + C ++ C T SY+C C GY D C DVDEC N DC
Sbjct: 493 QTIDICKHHANLC-LNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECT--SNPCTNGDC 549
Query: 87 VNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFLS 145
VN PG+Y C C+ GF C+D+DEC + C+ CVN GS++C C GF L+
Sbjct: 550 VNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELT 609
Query: 146 DNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGN 205
+ C+ E M N C + G C C+PGF L N R C
Sbjct: 610 TDGKNCVDHDECTTTNMCLNGMCIN-----EDGSFKCICKPGFVLAPNGRYCTDVDECQT 664
Query: 206 GG-CQH-TCDDTEQGPRCGCHIKFVLHTDGKTCIE-----TC--AVNNGGCDSKCHDAAT 256
G C + C ++E RC C + DG+ C++ TC + G C A T
Sbjct: 665 PGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVT 724
Query: 257 GVHCTCP-----VGFMLQP--------DRKTC----------KDIDECRLNNGGC-DHIC 292
C C G QP C +DI+EC L+ C + IC
Sbjct: 725 KSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGIC 784
Query: 293 RNTVGSFECSCKKGYKLLINERNCQDIDECSFDR-TCDH-ICVNTPGSFQCLCHRGYLLY 350
N GS+ C+C GY+ + RNC DIDEC +R CD+ +C NTPGS+ C C GY+
Sbjct: 785 ENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFR 844
Query: 351 GITH-CGDVDECSIN---RGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLK--CQ 404
T C D++EC N G CR N GS+ C C G +L G C + LK C
Sbjct: 845 TETETCEDINECESNPCVNGACR----NNLGSFNCECSPG-SKLSSTGLICIDSLKGTCW 899
Query: 405 GSPGASKAMLSCNRSGKKDTCALT 428
+ S+ ++ N + K C T
Sbjct: 900 LNIQDSRCEVNINGATLKSECCAT 923
Score = 197 bits (501), Expect = 4e-50
Identities = 138/432 (31%), Positives = 197/432 (45%), Gaps = 68/432 (15%)
Query: 28 QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDV--DECERE-DNAGC 82
+DV+EC C + C N+ S+ C C G T G G+ C D+ ++C + D C
Sbjct: 954 EDVNECEVFPGVCP-NGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDEC 1012
Query: 83 VHDCVNIPGNYR---CTCYDGFHLAHDGHNC----------------------------- 110
+H +PG +R C C G + C
Sbjct: 1013 IHP---VPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRP 1069
Query: 111 --LDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHG 167
D++EC G C C N +GS++C C GF L + C E C
Sbjct: 1070 FYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDE----CRISPDL 1125
Query: 168 CAH-ICRETPKGGIACECRPGFE----LTKNQRD---CKLTCNYGNGGCQHTCDDTEQGP 219
C IC TP G CEC G+E + KN D C+ GG TC +TE
Sbjct: 1126 CGSGICVNTP-GSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGG---TCVNTEGSF 1181
Query: 220 RCGCHIKFVLHTDGKTCIET--CAVNNGGC-DSKCHDAATGVHCTCPVGFMLQPDRKTCK 276
+C C + L + C++ C++++ C + KC + C+C G+ PDR+ C
Sbjct: 1182 QCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCT 1241
Query: 277 DIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFD-RTCD-HICVN 334
DIDEC + NGGCD C N+ GS+ECSC +GY L+ + R+C DIDEC + CD C N
Sbjct: 1242 DIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTN 1301
Query: 335 TPGSFQCLCHRGYLL-YGITHCGDVDECSINRGGCRFG-CINTPGSYQCTCPAGQGRLHW 392
PG ++CLC+ G++ + C DV+EC +N C FG C NT GS+ C C G +
Sbjct: 1302 IPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYS-VKK 1360
Query: 393 NGKDCTEPLKCQ 404
CT+ +C+
Sbjct: 1361 GTTGCTDVDECE 1372
Score = 196 bits (498), Expect = 9e-50
Identities = 135/460 (29%), Positives = 200/460 (43%), Gaps = 81/460 (17%)
Query: 29 DVDECVEGTDN--------CHIDAI----CQNTPR----SYKCICK--SGYTGDGK---- 66
D DEC+ C + A C+ P+ Y+ +C +G+ G
Sbjct: 1008 DEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTG 1067
Query: 67 --HCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQ 124
KD++EC+ C N G+++C C GF L + NC D+DEC C
Sbjct: 1068 RPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCG 1127
Query: 125 QS-CVNMMGSYECHCREGFFLSDNQHTCIQRPEEGM----NCMNKNHGCAH---ICRE-- 174
CVN GS+EC C EG+ E G NCM+ + C +CR
Sbjct: 1128 SGICVNTPGSFECECFEGY-------------ESGFMMMKNCMDIDE-CERNPLLCRGGT 1173
Query: 175 --TPKGGIACECRPGFELTKNQRDCK--LTCNYGNGGCQH-TCDDTEQGPRCGCHIKFVL 229
+G C+C G EL+ ++ DC C+ + C++ C + +C C+ +
Sbjct: 1174 CVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQA 1233
Query: 230 HTDGKTC--IETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGG 287
D + C I+ C + NGGCD++C ++ C+C G+ L PD ++C DIDEC N
Sbjct: 1234 TPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDI 1293
Query: 288 CDH-ICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHI--CVNTPGSFQCLCH 344
CD C N G + C C G+ ++ + C D++EC + C NT GSF C C
Sbjct: 1294 CDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQ 1353
Query: 345 RGYLLY-GITHCGDVDECSINRGGC--RFGCINTPGSYQCTCPAGQGRLHWNGK------ 395
GY + G T C DVDEC I C C+N PGS++C+C G W G
Sbjct: 1354 LGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREG-----WIGNGIKCID 1408
Query: 396 ---------DCTEPLKCQGSPGASKAMLSCNRSGKKDTCA 426
C+ +C +PG+ + S +G TC+
Sbjct: 1409 LDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCS 1448
Score = 188 bits (478), Expect = 2e-47
Identities = 137/405 (33%), Positives = 182/405 (44%), Gaps = 55/405 (13%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVN 88
D+DEC GT C I+A C NTP SY+C C G+TGDG C DVDEC N C+N
Sbjct: 1408 DLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLN 1467
Query: 89 IPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQ 148
+PG YRC C GF A D +C D+DEC+ N +C N+ G + C C +G+ L
Sbjct: 1468 VPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTG 1527
Query: 149 HTC--IQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNG 206
C I + +NC+N +C TP G C C P F+L G G
Sbjct: 1528 GNCTDIDECADPINCVN------GLCVNTP-GRYECNCPPDFQLNPT----------GVG 1570
Query: 207 GCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIET----------CAVNNG-----GCDSKC 251
C D G C++KF DG T C + G C++
Sbjct: 1571 -----CVDNRVG---NCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCP 1622
Query: 252 HDAATGVHCTCPVGFMLQPDRKT--CKDIDECRLNNGGCD-HICRNTVGSFECSCKKGYK 308
+T + CP G +P+ T +DIDEC+ G C C NT GSF+C C +GY
Sbjct: 1623 PVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYY 1682
Query: 309 LLINERNCQDIDEC-SFDRTC-DHICVNTPGSFQCLCHRGYL-LYGITHCGDVDEC---- 361
L + R C+DIDEC + C C NT G++ C+C Y+ + G +C D+ +
Sbjct: 1683 LSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYR 1742
Query: 362 SINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGS 406
S N C C C G+ WN K C EP G+
Sbjct: 1743 SYNGTTCENELPFNVTKRMCCCTYNVGKA-WN-KPC-EPCPTPGT 1784
Score = 187 bits (475), Expect = 4e-47
Identities = 140/430 (32%), Positives = 195/430 (45%), Gaps = 62/430 (14%)
Query: 27 AQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKH--CKDVDECEREDNAGCVH 84
A D+DEC E C + +C N S++C C +G++ + C+D+DEC DN C
Sbjct: 1806 AVDIDECKEIPGIC-ANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNL-CQR 1863
Query: 85 --DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREG 141
DC+N PG+YRC C GF L+ +G C+D +EC E C CV++ GSY+C C G
Sbjct: 1864 NADCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNG 1922
Query: 142 FFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC---- 197
F S +Q C+ E C + H C + + G C C PGFELT N DC
Sbjct: 1923 FKASQDQTMCMDVDE----C--ERHPCGNGTCKNTVGSYNCLCYPGFELTHN-NDCLDID 1975
Query: 198 KLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIET--CAVNNGGCD-SKCHDA 254
+ + +G C + +C C+ + L DGK CI+T C G C C +
Sbjct: 1976 ECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNL 2035
Query: 255 ATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGC-DHICRNTVGSFECSCKKGYKLLINE 313
C CP G+ ++ + C DI+EC + C C NT G F+C C G+ L N
Sbjct: 2036 EGSFRCICPPGYEVKSE--NCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNG 2093
Query: 314 RNCQDI-----------DECSFDRTCDH-----ICVNTPG----------------SFQC 341
R C D +CS + + C PG +FQ
Sbjct: 2094 RRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQD 2153
Query: 342 LCHRGYLLYGITH--CGDVDECSINRGGCRFG-CINTPGSYQCTCPAGQGRLHWNGKDCT 398
LC G+ H DV+EC + G C G CINT GS++C CP G L + G C
Sbjct: 2154 LCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGY-NLDYTGVRCV 2212
Query: 399 EPLKCQ-GSP 407
+ +C G+P
Sbjct: 2213 DTDECSIGNP 2222
Score = 183 bits (465), Expect = 6e-46
Identities = 107/323 (33%), Positives = 149/323 (46%), Gaps = 22/323 (6%)
Query: 53 YKCICKSG--YTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNC 110
YK IC G YT DG+ D+DEC+ N C+N G++RC C G+ G +C
Sbjct: 2433 YKKICPHGPGYTTDGR---DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSC 2489
Query: 111 LDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAH 170
+D+DEC++ C C N GSY+C C G+ L ++ TC E C K H C
Sbjct: 2490 IDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDE----CQTKQHNCQF 2545
Query: 171 ICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNG----GCQHTCDDTEQGPRCGCHIK 226
+C T GG C+C PGF T++ C G+ G + C +T C C
Sbjct: 2546 LCVNT-LGGFTCKCPPGF--TQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRG 2602
Query: 227 FVLHTDGKTC--IETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLN 284
F L G C ++ C N+ C C + G C CP G++ C D +EC
Sbjct: 2603 FSLDATGLNCEDVDECDGNHR-CQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNP 2661
Query: 285 NGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRT-CDHICVNTPGSFQCLC 343
N C NT+GS++C+C G+ C D++ECS + C++ C NT G + C C
Sbjct: 2662 NACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGC 2721
Query: 344 HRGYLLYGITHCGDVDECSINRG 366
GY G HC V N+G
Sbjct: 2722 PPGYYRVGQGHC--VSGMGFNKG 2742
Score = 178 bits (451), Expect = 3e-44
Identities = 133/413 (32%), Positives = 167/413 (40%), Gaps = 107/413 (25%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAGCVHDC 86
D+DEC+ C D C N+ SY+C C GY DG+ C D+DECE + C
Sbjct: 1242 DIDECMIMNGGC--DTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQC 1299
Query: 87 VNIPGNYRCTCYDGFHLAHDGHNCLDV--------------------------------- 113
NIPG YRC CYDGF + D C+DV
Sbjct: 1300 TNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVK 1359
Query: 114 ---------DECAEGNGGCQQ--SCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCM 162
DEC G C SC+N+ GS++C CREG+ N CI E C
Sbjct: 1360 KGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWI--GNGIKCIDLDE----CS 1413
Query: 163 NKNHGCA--HICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPR 220
N H C+ C TP G C C GF G+G TC D
Sbjct: 1414 NGTHQCSINAQCVNTP-GSYRCACSEGFT--------------GDG---FTCSD------ 1449
Query: 221 CGCHIKFVLHTDGKTCIETCAVNNGGCDS-KCHDAATGVHCTCPVGFMLQPDRKTCKDID 279
++ CA N C++ +C + C C +GF D ++C+DID
Sbjct: 1450 ----------------VDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDID 1493
Query: 280 ECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTC-DHICVNTPGS 338
EC N C N G F C C GY+L NC DIDEC+ C + +CVNTPG
Sbjct: 1494 ECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGR 1553
Query: 339 FQCLCHRGYLLYGITHCGDVDECSINR-GGC--RFGCINTPGSYQCTCPAGQG 388
++C C + L T G VD NR G C +FG GS C G G
Sbjct: 1554 YECNCPPDFQL-NPTGVGCVD----NRVGNCYLKFG-PRGDGSLSCNTEIGVG 1600
Score = 170 bits (430), Expect = 7e-42
Identities = 109/370 (29%), Positives = 162/370 (43%), Gaps = 29/370 (7%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVN 88
D +ECV +C CQN S++CIC GY ++C D++EC+ + N C N
Sbjct: 2016 DTNECVALPGSCS-PGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNICLFGSCTN 2074
Query: 89 IPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQ 148
PG ++C C GF L+ +G C D Q C + +C + F + +
Sbjct: 2075 TPGGFQCLCPPGFVLSDNGRRCFDTR---------QSFCFTNFENGKCSVPKAFNTTKAK 2125
Query: 149 HTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCK---LTCNYGN 205
C + P EG +C + + C G + D + C
Sbjct: 2126 CCCSKMPGEGWG------DPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESP 2179
Query: 206 GGCQH-TCDDTEQGPRCGCHIKFVLHTDGKTCIET--CAVNNGGCDSKCHDAATGVHCTC 262
G C + C +T+ RC C + + L G C++T C++ N + C + C C
Sbjct: 2180 GICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNC 2239
Query: 263 PVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDEC 322
GF P C+DI+EC N C C NT GS+EC+C GY L +++ C+D+DEC
Sbjct: 2240 NEGFEPGP-MMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDEC 2298
Query: 323 SFD-RTCDH---ICVNTPGSFQCLCHRGYLLYGITH-CGDVDECSINRGGCRFG-CINTP 376
+ C+ +C N G+F C+C G C D +EC G C G C+N
Sbjct: 2299 AEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNII 2358
Query: 377 GSYQCTCPAG 386
GSY+C C G
Sbjct: 2359 GSYRCECNEG 2368
Score = 162 bits (411), Expect = 1e-39
Identities = 127/440 (28%), Positives = 180/440 (40%), Gaps = 79/440 (17%)
Query: 26 AAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGCV 83
A QDVDEC C C NT S++C C +G+ + + C+D+DEC
Sbjct: 273 ACQDVDECQAIPGICQ-GGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICET 331
Query: 84 HDCVNIPGNYRCTCYDGFHLAHDGHNCLD--VDECAEG--NGGCQQSCVNMMGSYECHCR 139
+C N G+Y C C G+ + DG C+D C G NG C Q M +C C
Sbjct: 332 GECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCE 391
Query: 140 EG--FFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRE-TPKGGI--ACECRPGFELTKNQ 194
G + + C R E +C + P GGI + RPG
Sbjct: 392 PGRCWGIGTIPEACPVRGSEEYR---------RLCMDGLPMGGIPGSAGSRPGGTGGNGF 442
Query: 195 RDCKLTCNYGNGG------------------------------------------CQH-- 210
YG GG C+H
Sbjct: 443 APSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHA 502
Query: 211 ------TCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGC-DSKCHDAATGVHCTCP 263
C T RC C++ + +G CI+ + C + C + +C C
Sbjct: 503 NLCLNGRCIPTVSSYRCECNMGYKQDANG-DCIDVDECTSNPCTNGDCVNTPGSYYCKCH 561
Query: 264 VGFMLQPDRKTCKDIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKLLINERNCQDIDEC 322
GF P ++ C DIDEC N C + C NT GSF+C C G++L + +NC D DEC
Sbjct: 562 AGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDEC 621
Query: 323 SFDRTC-DHICVNTPGSFQCLCHRGYLLY-GITHCGDVDECSINRGGCRFG-CINTPGSY 379
+ C + +C+N GSF+C+C G++L +C DVDEC G C G CIN+ GS+
Sbjct: 622 TTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQ-TPGICMNGHCINSEGSF 680
Query: 380 QCTCPAGQGRLHWNGKDCTE 399
+C CP G + +G+ C +
Sbjct: 681 RCDCPPGLA-VGMDGRVCVD 699
Score = 159 bits (401), Expect = 2e-38
Identities = 141/504 (27%), Positives = 204/504 (40%), Gaps = 62/504 (12%)
Query: 69 KDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQ-SC 127
+D+DEC+ +C+N G+++C C G++L+ D C D+DEC G C +C
Sbjct: 1649 EDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTC 1708
Query: 128 VNMMGSYECHCREGFFLSDNQHTCIQ-------RPEEGMNCMNK--------------NH 166
N +G+Y C C + + H C+ R G C N+ N
Sbjct: 1709 YNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNV 1768
Query: 167 GCA--HICRETPKGGIA-----CECRPGFEL---TKNQRDCKLTCNYGNGGCQH-TCDDT 215
G A C P G A C PGF T D C G C + C +
Sbjct: 1769 GKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDID-ECKEIPGICANGVCINQ 1827
Query: 216 EQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGC--DSKCHDAATGVHCTCPVGFMLQPD 271
RC C F + C I+ C+ + C ++ C ++ C C GF L P+
Sbjct: 1828 IGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPN 1887
Query: 272 RKTCKDIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDH 330
C D +EC C H +C + GS++C C G+K ++ C D+DEC +
Sbjct: 1888 G-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNG 1946
Query: 331 ICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGG-CRFG-CINTPGSYQCTCPAGQG 388
C NT GS+ CLC+ G+ L C D+DECS G CR G C N GS++C C G
Sbjct: 1947 TCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGY- 2005
Query: 389 RLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPSRARFLPESENGFTVSCG 448
L +GK+C + +C PG+ N G + C + +SEN ++
Sbjct: 2006 ELTPDGKNCIDTNECVALPGSCSPGTCQNLEG-----SFRCICPPGYEVKSENCIDINEC 2060
Query: 449 TPSPRAAPARAGHNGNSTNSNHCHEAAVLSIKQRASFKIKDAKCRLHLRNKGK------- 501
P + N C VLS R F + + C + N GK
Sbjct: 2061 DEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFEN-GKCSVPKAF 2119
Query: 502 -TEEA----GRITGPG-GAPCSEC 519
T +A ++ G G G PC C
Sbjct: 2120 NTTKAKCCCSKMPGEGWGDPCELC 2143
Score = 144 bits (364), Expect = 3e-34
Identities = 129/469 (27%), Positives = 185/469 (39%), Gaps = 85/469 (18%)
Query: 46 CQNTPRS----YKCICKSGY--TGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYD 99
CQ P + +C SG T DG+ D++EC + + C N+ G+YRC C
Sbjct: 741 CQPCPAKNSAEFHGLCSSGVGITVDGR---DINECALDPDICANGICENLRGSYRCNCNS 797
Query: 100 GFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFLSDNQHTCIQRPEEG 158
G+ G NC+D+DEC C C N GSY C C G+ TC E
Sbjct: 798 GYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETC-----ED 852
Query: 159 MNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC----KLTC--NYGNGGCQHTC 212
+N N CR G CEC PG +L+ C K TC N + C+
Sbjct: 853 INECESNPCVNGACRNN-LGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNI 911
Query: 213 DDTEQGPRC-------------GCHI-----KFVLHTDGKTC--IETCAVNNGGC-DSKC 251
+ C C + + + G TC + C V G C + +C
Sbjct: 912 NGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRC 971
Query: 252 HDAATGVHCTCPVGFMLQPDRKTCKDI--DECRL--NNGGCDH---------ICRNTVGS 298
++ HC CP G L + C DI ++C L + C H C VG+
Sbjct: 972 VNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGA 1031
Query: 299 ----------------FECSCKKGY------KLLINERNCQDIDEC-SFDRTCDH-ICVN 334
+E C +G +L +DI+EC +F C + C N
Sbjct: 1032 AWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRN 1091
Query: 335 TPGSFQCLCHRGYLL-YGITHCGDVDECSINRGGCRFG-CINTPGSYQCTCPAGQGRLHW 392
T GSF+C C+ G+ L +C D+DEC I+ C G C+NTPGS++C C G
Sbjct: 1092 TIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFM 1151
Query: 393 NGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPSRARFLPESEN 441
K+C + +C+ +P + N G + CP P E+
Sbjct: 1152 MMKNCMDIDECERNPLLCRGGTCVNTEG---SFQCDCPLGHELSPSRED 1197
Score = 144 bits (363), Expect = 4e-34
Identities = 131/456 (28%), Positives = 179/456 (39%), Gaps = 106/456 (23%)
Query: 21 AQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGD--GKHCKDVDECERED 78
A S++ QD+DEC N + C N P + CIC GY D G +C D+DEC D
Sbjct: 1483 ASDSRSCQDIDEC--SFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDEC--AD 1538
Query: 79 NAGCVHD-CVNIPGNYRCTCYDGFHLAHDGHNCLD--VDEC-------AEGNGGC----- 123
CV+ CVN PG Y C C F L G C+D V C +G+ C
Sbjct: 1539 PINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIG 1598
Query: 124 ----QQSCVNMMG--------------SYE----CHCREGF------FLSDNQHTCIQRP 155
+ SC +G S E C EGF + ++ C + P
Sbjct: 1599 VGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELP 1658
Query: 156 E--EGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCK--LTCNYGNGGC-QH 210
+G NC+N G CEC G+ L+++ R C+ C G C
Sbjct: 1659 GLCQGGNCIN------------TFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPG 1706
Query: 211 TCDDTEQGPRCGCHIKFVLHTDGKTCIET----C--AVNNGGCDSKCHDAATGVHCTCPV 264
TC +T C C +++ G C++ C + N C+++ T C C
Sbjct: 1707 TCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTY 1766
Query: 265 -----------------------------GFMLQPDRKTCKDIDECRLNNGGC-DHICRN 294
GF DIDEC+ G C + +C N
Sbjct: 1767 NVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCIN 1826
Query: 295 TVGSFECSCKKGYKLLINERNCQDIDECS-FDRTCDH--ICVNTPGSFQCLCHRGYLLYG 351
+GSF C C G+ C+DIDECS D C C+N+PGS++C C G+ L
Sbjct: 1827 QIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSP 1886
Query: 352 ITHCGDVDECSINRGGCRFG-CINTPGSYQCTCPAG 386
C D +EC C G C++ GSYQC C G
Sbjct: 1887 NGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNG 1922
Score = 139 bits (349), Expect = 2e-32
Identities = 106/383 (27%), Positives = 153/383 (39%), Gaps = 97/383 (25%)
Query: 69 KDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCV 128
+DV+EC C+N G++RC C G++L + G C+D DEC+ GN +C
Sbjct: 2170 EDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCT 2229
Query: 129 NMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHG------CAHICRETPKGGIAC 182
N++GS+EC+C EGF P MNC + N CA C T G C
Sbjct: 2230 NVIGSFECNCNEGF-----------EPGPMMNCEDINECAQNPLLCAFRCMNT-FGSYEC 2277
Query: 183 ECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAV 242
C G+ L ++Q+ CK ++ CA
Sbjct: 2278 TCPIGYALREDQKMCK-------------------------------------DLDECAE 2300
Query: 243 NNGGCDSK---CHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDH-ICRNTVGS 298
C+S+ C + C CP G +PD + C D +ECR G C++ C N +GS
Sbjct: 2301 GLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGS 2360
Query: 299 FECSCKKGY--------------------------KLLINERNCQDIDECSFD--RTCDH 330
+ C C +G+ ++ + RN EC D R H
Sbjct: 2361 YRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGH 2420
Query: 331 ICVNTP----GSFQCLCHRGYLLYGITHCG-DVDECSINRGGCRFG-CINTPGSYQCTCP 384
C P ++ +C G G T G D+DEC + C G CINT GS++C C
Sbjct: 2421 QCELCPLPGTAQYKKICPHG---PGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCK 2477
Query: 385 AGQGRLHWNGKDCTEPLKCQGSP 407
G +G C + +C SP
Sbjct: 2478 VGY-TTDISGTSCIDLDECSQSP 2499
Score = 121 bits (303), Expect = 4e-27
Identities = 69/197 (35%), Positives = 94/197 (47%), Gaps = 12/197 (6%)
Query: 22 QYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGD--GKHCKDVDECEREDN 79
Q+ A D +EC C ICQNTP S+ C C+ G++ D G +C+DVDEC + N
Sbjct: 2564 QHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDEC--DGN 2621
Query: 80 AGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCR 139
C H C NI G YRC C G+ + + C+D +EC+ N SC N +GSY+C C
Sbjct: 2622 HRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACP 2681
Query: 140 EGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKL 199
GF C + C + + C + C T +GG C C PG+ Q C
Sbjct: 2682 SGFSFDQFSSAC----HDVNECSSSKNPCNYGCSNT-EGGYLCGCPPGY-YRVGQGHCVS 2735
Query: 200 TCNYGNGGCQHTCDDTE 216
+ G Q+ DTE
Sbjct: 2736 GMGFNKG--QYLSLDTE 2750
Score = 103 bits (258), Expect = 6e-22
Identities = 113/415 (27%), Positives = 158/415 (38%), Gaps = 81/415 (19%)
Query: 19 RAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECER 76
+ ++ ++ +D+DEC C C NT SY C+C GY + DG C D
Sbjct: 308 KQSETTQKCEDIDECSIIPGICETGE-CSNTVGSYFCVCPRGYVTSTDGSRCID------ 360
Query: 77 EDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYEC 136
G C+ G NG C Q M +C
Sbjct: 361 -QRTG--------------MCFSGL-----------------VNGRCAQELPGRMTKMQC 388
Query: 137 HCREG--FFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRE-TPKGGI--ACECRPGFELT 191
C G + + C R E +C + P GGI + RPG
Sbjct: 389 CCEPGRCWGIGTIPEACPVRGSEEYR---------RLCMDGLPMGGIPGSAGSRPGGTGG 439
Query: 192 KNQRDCKLTCNYGNGGC-------QHTCDDTEQGPRCGCHIKFVLHTDGKT----CIETC 240
YG GG + G G + + T G T I+ C
Sbjct: 440 NGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIIT-GLTILNQTIDIC 498
Query: 241 AVNNGGC-DSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLN---NGGCDHICRNTV 296
+ C + +C + C C +G+ Q C D+DEC N NG C NT
Sbjct: 499 KHHANLCLNGRCIPTVSSYRCECNMGYK-QDANGDCIDVDECTSNPCTNGD----CVNTP 553
Query: 297 GSFECSCKKGYKLLINERNCQDIDECSFDRTC--DHICVNTPGSFQCLCHRGY-LLYGIT 353
GS+ C C G++ ++ C DIDEC + + CVNT GSFQC+C+ G+ L
Sbjct: 554 GSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGK 613
Query: 354 HCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPG 408
+C D DEC+ CIN GS++C C G L NG+ CT+ +CQ +PG
Sbjct: 614 NCVDHDECTTTNMCLNGMCINEDGSFKCICKPG-FVLAPNGRYCTDVDECQ-TPG 666
Score = 85.5 bits (210), Expect = 2e-16
Identities = 104/345 (30%), Positives = 131/345 (37%), Gaps = 82/345 (23%)
Query: 88 NIPGN-YRCTCYDGFHLAHDGHNCLDVDECAE--GNGGCQQSCVNMMGSYECHCREGFFL 144
N+ G+ + C G+ G+ C+ V C G+G C + NM C C G
Sbjct: 87 NVCGSRFHSYCCPGWKTLPGGNQCI-VPICRNSCGDGFCSRP--NM-----CTCSSGQIS 138
Query: 145 SDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYG 204
S IQ+ + CMN CA + KG I C Q C+ C G
Sbjct: 139 STCGSKSIQQCS--VRCMNGGT-CADDHCQCQKGYIGTYC--------GQPVCENGCQNG 187
Query: 205 NGGCQHTCDDTEQGP-RCGCHIKFV---LHTDGKTCIETCAVNNGGCDSKCHDAATGVHC 260
G C GP RC C F D +T VNN C TG+ C
Sbjct: 188 -GRCI--------GPNRCACVYGFTGPQCERDYRTGPCFTQVNN----QMCQGQLTGIVC 234
Query: 261 T------------------CPV-------GFMLQPDRKTCKDIDECRLNNGGCDH-ICRN 294
T CP GF+ C+D+DEC+ G C C N
Sbjct: 235 TKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCIN 294
Query: 295 TVGSFECSCKKGYKLLINERNCQDIDECS-FDRTCD-HICVNTPGSFQCLCHRGYLLYGI 352
TVGSFEC C G+K + C+DIDECS C+ C NT GS+ C+C RGY+
Sbjct: 295 TVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVT--- 351
Query: 353 THCGDVDECSINRGG-CRFGCIN------TPG---SYQCTCPAGQ 387
D C R G C G +N PG QC C G+
Sbjct: 352 --STDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGR 394
Score = 34.7 bits (78), Expect = 0.46
Identities = 35/130 (26%), Positives = 43/130 (33%), Gaps = 20/130 (15%)
Query: 708 PCPRGTYQPEAGRTLCFPCGGGL--TTKHEGAISFQDC-DTKVQCSPGHYYNTSIHRCIR 764
PC G G C C G T + I +C V C G NT
Sbjct: 543 PCTNGDCVNTPGSYYC-KCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTD------ 595
Query: 765 CAMGSYQPDFRQNFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEF-----TGYIESPN 819
GS+Q F G D D T+ C N C E G F G++ +PN
Sbjct: 596 ---GSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPN 652
Query: 820 YPGNYPAGVE 829
G Y V+
Sbjct: 653 --GRYCTDVD 660
Score = 31.2 bits (69), Expect = 5.0
Identities = 15/51 (29%), Positives = 22/51 (43%), Gaps = 8/51 (15%)
Query: 633 GTKCVSCPQGTYYHGQTEQCV--------PCPAGTFQEREGQLSCDLCPGS 675
G+ +CP G + +TE C PC G + G +C+ PGS
Sbjct: 831 GSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGS 881
Score = 31.2 bits (69), Expect = 5.0
Identities = 48/207 (23%), Positives = 69/207 (33%), Gaps = 50/207 (24%)
Query: 625 CRPGQ--HRAGTKCVSCPQGTY--YHG----QTEQCV---PCPAGTFQEREGQLSCDLCP 673
C GQ + G+ CP G Y G T++C PC GT G C+
Sbjct: 2182 CSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNE 2241
Query: 674 GSDAHGPLGATNVTTCAGQ------------------CPPGQHSVDGFKPCQ---PCPRG 712
G + + ++ CA CP G + K C+ C G
Sbjct: 2242 GFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEG 2301
Query: 713 TYQPEAGRTLC----------FPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRC 762
+ E+ +C P G EG + +C TK PG N RC
Sbjct: 2302 LHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTK----PGICEN---GRC 2354
Query: 763 IRCAMGSYQPDFRQNFCSRCPGNTSTD 789
+ +GSY+ + + F S G D
Sbjct: 2355 VN-IIGSYRCECNEGFQSSSSGTECLD 2380
Score = 31.2 bits (69), Expect = 5.0
Identities = 46/198 (23%), Positives = 66/198 (33%), Gaps = 40/198 (20%)
Query: 616 GERAEPMESCRPGQHRAGTKCVS--------CPQGTYYHGQTEQCV---------PCPAG 658
G E ++ C G HR C + CPQG H Q QCV C +
Sbjct: 2609 GLNCEDVDEC-DGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSA 2667
Query: 659 TFQEREGQLSCDLCPGSDAHGPLGAT--NVTTCAGQ---CPPGQHSVDGFKPCQPCPRGT 713
+ G C CP + + +V C+ C G + +G C CP G
Sbjct: 2668 SCYNTLGSYKC-ACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLC-GCPPGY 2725
Query: 714 YQPEAGRTLCFPCGGGLTTKHEGAISFQ-DCDTKVQCSPGHYYNTSIHRCIRCAMGSY-Q 771
Y+ G C G+ +S + D + SP C C + Y +
Sbjct: 2726 YRVGQGH-----CVSGMGFNKGQYLSLDTEVDEENALSP--------EACYECKINGYSK 2772
Query: 772 PDFRQNFCSRCPGNTSTD 789
D RQ P T+ +
Sbjct: 2773 KDSRQKRSIHEPDPTAVE 2790
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 203 bits (516), Expect = 7e-52
Identities = 139/423 (32%), Positives = 193/423 (45%), Gaps = 72/423 (17%)
Query: 19 RAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTG--DGKHCKDVDECER 76
R ++ + D+DEC + C C+NT S+ CIC +G+ +G +C DVDEC R
Sbjct: 906 RFSEQQRKCVDIDECTQVQHLCS-QGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLR 964
Query: 77 EDNAG---CVH-------------------------------------DCVNIPGNYRCT 96
D G CV+ CVN PG+Y+C
Sbjct: 965 PDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCV 1024
Query: 97 -CYDGFHLAHDGHN--CLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTC-- 151
C +GF G N CLDVDEC E N C N+ GSY C C +G+ + + C
Sbjct: 1025 PCTEGFR----GWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRD 1080
Query: 152 IQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT--CNYGNGGCQ 209
I ++G C+N C+ T +G C C G++L+ + C+ C + +
Sbjct: 1081 IDECQQGNLCVNGQ------CKNT-EGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAH 1133
Query: 210 HTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCD-SKCHDAATGVHCTCPVGF 266
C +TE +C C + G C I C + C C + A CTCP GF
Sbjct: 1134 GQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGF 1193
Query: 267 MLQPDRKTCKDIDECRLNNGGC--DHICRNTVGSFECSCKKGYKLLINERNCQDIDECSF 324
L D KTC+DI+EC + G C C NT GSF C C++G+ + + R C+DIDEC
Sbjct: 1194 QLD-DNKTCQDINECE-HPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVN 1251
Query: 325 DRTCDH--ICVNTPGSFQCLCHRGYLL-YGITHCGDVDECSINRGGC-RFGCINTPGSYQ 380
+ CD C NT GSF+CLC++G+ C DV+EC + G C C N GS+
Sbjct: 1252 NTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFL 1311
Query: 381 CTC 383
C C
Sbjct: 1312 CVC 1314
Score = 194 bits (494), Expect = 3e-49
Identities = 119/384 (30%), Positives = 178/384 (46%), Gaps = 17/384 (4%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGCVHDC 86
+++EC D C C N P Y CIC GY + + C D+DEC + + C
Sbjct: 874 EINECTVNPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRC 932
Query: 87 VNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYEC-HCREGFFLS 145
N G++ C C GF + +G NC+DVDEC + + CVN +G++ C +C G+ ++
Sbjct: 933 ENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMT 992
Query: 146 DNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGN 205
R E+ C+N + C +P C GF Q C N
Sbjct: 993 QR-----GRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPN 1047
Query: 206 GGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAATGVHCTCP 263
C + E C CH + D K C I+ C N + +C + CTC
Sbjct: 1048 VCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCG 1107
Query: 264 VGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECS 323
G+ L + C+DIDEC+ + CRNT GSF+C C +GY+ +C+DI+EC
Sbjct: 1108 QGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECL 1167
Query: 324 FDRT-CDH-ICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGC--RFGCINTPGSY 379
D++ C C+NT GS+ C C G+ L C D++EC + G C + C+NT GS+
Sbjct: 1168 EDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECE-HPGLCGPQGECLNTEGSF 1226
Query: 380 QCTCPAGQGRLHWNGKDCTEPLKC 403
C C G + +G+ C + +C
Sbjct: 1227 HCVCQQGFS-ISADGRTCEDIDEC 1249
Score = 165 bits (417), Expect = 2e-40
Identities = 131/427 (30%), Positives = 182/427 (42%), Gaps = 78/427 (18%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTG--DGKHCKDVDECEREDNAGCVH-D 85
DVDEC+E N + C N SY C C GYT D KHC+D+DEC++ + CV+
Sbjct: 1039 DVDECLE--PNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNL--CVNGQ 1094
Query: 86 CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLS 145
C N G++RCTC G+ L+ C D+DEC + C N GS++C C +G+ S
Sbjct: 1095 CKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRAS 1154
Query: 146 DNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQ--RDCKLTCNY 203
C E+ C+ C G C C GF+L N+ +D +
Sbjct: 1155 GLGDHC----EDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHP 1210
Query: 204 GNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSK--CHDAATGVH 259
G G Q C +TE C C F + DG+TC I+ C VNN CDS C + A
Sbjct: 1211 GLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDSHGFCDNTAGSFR 1269
Query: 260 CTCPVGFMLQPDRKTCKDIDECRLNNGGC-DHICRNTVGSFECSC---KKGYKLLINE-- 313
C C GF D + C D++EC L +G C + C N GSF C C + Y + +
Sbjct: 1270 CLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCR 1329
Query: 314 -RNCQDID-----------ECSFDRT----CDHI---------CVNTPGS--------FQ 340
R D+D EC ++ CD++ C T G+ F
Sbjct: 1330 SRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFP 1389
Query: 341 C----------LCHRGYLLY---------GITHCGDVDECSI-NRGGCRFG-CINTPGSY 379
C +C +G G + D DEC + + C+ G C+NT Y
Sbjct: 1390 CPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGY 1449
Query: 380 QCTCPAG 386
+C C G
Sbjct: 1450 ECYCKQG 1456
Score = 155 bits (391), Expect = 2e-37
Identities = 124/431 (28%), Positives = 182/431 (42%), Gaps = 84/431 (19%)
Query: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGC 82
K +D+DEC +G N ++ C+NT S++C C GY + C+D+DEC+ C
Sbjct: 1076 KHCRDIDECQQG--NLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHL--C 1131
Query: 83 VH-DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCRE 140
H C N G+++C C G+ + G +C D++EC E CQ+ C+N GSY+C C +
Sbjct: 1132 AHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPD 1191
Query: 141 GFFLSDNQHTC--IQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCK 198
GF L DN+ TC I E C G C T +G C C+ GF ++ + R C+
Sbjct: 1192 GFQLDDNK-TCQDINECEHPGLC-----GPQGECLNT-EGSFHCVCQQGFSISADGRTCE 1244
Query: 199 -LTCNYGNGGCQHT--CDDTEQGPRCGCHIKFVLHTDGKTCIET--CAVNNGGC-DSKCH 252
+ N C CD+T RC C+ F DG+ C++ C + +G C ++ C
Sbjct: 1245 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCE 1304
Query: 253 DAATGVHCTC--------PVGFMLQPDRKTCKDID---------EC--RLNNGG-CDHIC 292
+ C C P+ + T D+D EC LN+ CD++
Sbjct: 1305 NVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVL 1364
Query: 293 RNTVGSFECSCKKGYKLLIN-----------------------------------ERNCQ 317
V EC C G N N +
Sbjct: 1365 APNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYK 1424
Query: 318 DIDECSF--DRTCDH-ICVNTPGSFQCLCHRGYLLYGIT-HCGDVDECSINRGGCRFG-C 372
D DEC C + C+NT ++C C +G + C D+DEC + C G C
Sbjct: 1425 DADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQ-DPSSCIDGQC 1483
Query: 373 INTPGSYQCTC 383
+NT GSY C C
Sbjct: 1484 VNTEGSYNCFC 1494
Score = 115 bits (287), Expect = 3e-25
Identities = 90/327 (27%), Positives = 134/327 (40%), Gaps = 51/327 (15%)
Query: 24 SKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAG 81
+K QD++EC E C C NT S+ C+C+ G++ DG+ C+D+DEC
Sbjct: 1198 NKTCQDINEC-EHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCD 1256
Query: 82 CVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCRE 140
C N G++RC CY GF DG C+DV+EC +G C ++ C N+ GS+ C C +
Sbjct: 1257 SHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCAD 1316
Query: 141 GFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPK-----------GGIACECRPGFE 189
+NQ P G C ++ + + PK C+
Sbjct: 1317 -----ENQE---YSPMTGQ-CRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPN 1367
Query: 190 LTKNQRDCKLTCNYGNGGCQ-------HTCDDTEQGPR---------CGCHIKFVLHTDG 233
+TK + C +G+ C+ T + TE P+ + D
Sbjct: 1368 VTKQECCCTSGAGWGDN-CEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDA 1426
Query: 234 KTCI----ETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCD 289
C+ E C NG C + G C C G P + C D+DEC+ + D
Sbjct: 1427 DECLLFGQEIC--KNGFC----LNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCID 1480
Query: 290 HICRNTVGSFECSCKKGYKLLINERNC 316
C NT GS+ C C L +E+ C
Sbjct: 1481 GQCVNTEGSYNCFCTHPMVLDASEKRC 1507
Score = 85.5 bits (210), Expect = 2e-16
Identities = 75/289 (25%), Positives = 104/289 (35%), Gaps = 43/289 (14%)
Query: 58 KSGYTGDGKHCKDVDECEREDNAGCVHD-CVNIPGNYRCTCYDGFHLAHDGHNCLDVDEC 116
+S G++ KD DEC C + C+N Y C C G + C D+DEC
Sbjct: 1413 ESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDEC 1472
Query: 117 AEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETP 176
+ + CVN GSY C C L ++ CI RP E + + +C E
Sbjct: 1473 QDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCI-RPAESNEQIEETDVYQDLCWEHL 1531
Query: 177 KGGIACECRPGFELTKNQRDCKLTCNYGNG-GCQHTC----DDTEQGPRCGCHIKFVLHT 231
C RP +C C YG G Q D + C +
Sbjct: 1532 SDEYVCS-RPLVGKQTTYTEC--CCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQP 1588
Query: 232 DGKTCI-----------------------------ETCAVNNGGCDSKCHDAATGVHCTC 262
G+ + E C + NG + +C G C C
Sbjct: 1589 YGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDC 1648
Query: 263 PVGFMLQPDRKTCKDIDEC-RLNN--GGCDHI-CRNTVGSFECSCKKGY 307
G+ L + TC D++EC LNN C + C NT GS++C C GY
Sbjct: 1649 FDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGY 1697
Score = 80.5 bits (197), Expect = 7e-15
Identities = 114/458 (24%), Positives = 155/458 (33%), Gaps = 98/458 (21%)
Query: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTG--DGKHCKDVDECEREDNAGC 82
+ +D+DECV T C C NT S++C+C G+ DG+ C DV+ECE
Sbjct: 1241 RTCEDIDECVNNTV-CDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCG 1299
Query: 83 VHDCVNIPGNYRCTCYD-GFHLAHDGHNC---------LDVDECAEGNGGCQQS------ 126
C N+ G++ C C D + C +DVD+ E C +
Sbjct: 1300 EAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASL 1359
Query: 127 CVNMMG----SYECHCREGFFLSDN--------------QHTC------IQRPEEGMNCM 162
C N++ EC C G DN C + E
Sbjct: 1360 CDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAG 1419
Query: 163 NKNHGCAHIC----RETPKGGIACECRPGFELTKNQRD----CKLTCNYGNGGCQHT--- 211
+N+ A C +E K G RPG+E Q KL C + CQ
Sbjct: 1420 GENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQC-FDMDECQDPSSC 1478
Query: 212 ----CDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHD-------------- 253
C +TE C C VL K CI N ++ +
Sbjct: 1479 IDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCS 1538
Query: 254 ------AATGVHCTCPVGFMLQPDRKTC--KDIDE----CRLN-NGGCDHICRNTVGSF- 299
T C C G C KD D+ C + G R+ + F
Sbjct: 1539 RPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFS 1598
Query: 300 ECSCKKGYKLLINERNCQDI-----DECSFDRTCDH-ICVNTPGSFQCLCHRGYLL-YGI 352
E + I +R +EC C++ CV + C C GY L
Sbjct: 1599 EQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAK 1658
Query: 353 THCGDVDECS--INRGG-CRFG-CINTPGSYQCTCPAG 386
C DV+EC NR C+ CINT GSY+C C G
Sbjct: 1659 MTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPG 1696
Score = 60.8 bits (146), Expect = 6e-09
Identities = 30/76 (39%), Positives = 42/76 (55%), Gaps = 5/76 (6%)
Query: 81 GCVHD-CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGG---CQQS-CVNMMGSYE 135
GC + CV + Y C C+DG+HL C+DV+EC E N C+ + C+N GSY+
Sbjct: 1631 GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYK 1690
Query: 136 CHCREGFFLSDNQHTC 151
C C G+ SD + C
Sbjct: 1691 CLCLPGYVPSDKPNYC 1706
Score = 44.7 bits (104), Expect = 4e-04
Identities = 22/47 (46%), Positives = 28/47 (59%), Gaps = 2/47 (4%)
Query: 343 CHRGYLLYGITHCGDVDECSINRGGCRFG-CINTPGSYQCTCPAGQG 388
C GY T C D++EC + +G C G C+NT GSY+CTC G G
Sbjct: 612 CLPGYKRVNNTFCQDINECQL-QGVCPNGECLNTMGSYRCTCKIGFG 657
Score = 43.5 bits (101), Expect = 0.001
Identities = 20/46 (43%), Positives = 27/46 (58%), Gaps = 2/46 (4%)
Query: 303 CKKGYKLLINERNCQDIDECSFDRTCDH-ICVNTPGSFQCLCHRGY 347
C GYK +N CQDI+EC C + C+NT GS++C C G+
Sbjct: 612 CLPGYKR-VNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 656
Score = 38.9 bits (89), Expect = 0.024
Identities = 15/33 (45%), Positives = 23/33 (69%)
Query: 275 CKDIDECRLNNGGCDHICRNTVGSFECSCKKGY 307
C+DI+EC+L + C NT+GS+ C+CK G+
Sbjct: 624 CQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 656
Score = 38.5 bits (88), Expect = 0.032
Identities = 21/65 (32%), Positives = 31/65 (47%), Gaps = 3/65 (4%)
Query: 92 NYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFLSDNQHT 150
N C G+ ++ C D++EC + G C C+N MGSY C C+ GF +
Sbjct: 607 NQMMECLPGYKRVNNTF-CQDINEC-QLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSS 664
Query: 151 CIQRP 155
C+ P
Sbjct: 665 CVPDP 669
Score = 37.4 bits (85), Expect = 0.070
Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 5/70 (7%)
Query: 57 CKSGYTG-DGKHCKDVDECEREDNAGCVH-DCVNIPGNYRCTCYDGFHLAHDGHNCL-DV 113
C GY + C+D++EC+ + C + +C+N G+YRCTC GF +C+ D
Sbjct: 612 CLPGYKRVNNTFCQDINECQLQ--GVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDP 669
Query: 114 DECAEGNGGC 123
+E G C
Sbjct: 670 PVISEEKGPC 679
Score = 33.5 bits (75), Expect = 1.0
Identities = 17/40 (42%), Positives = 22/40 (55%), Gaps = 2/40 (5%)
Query: 29 DVDECVEGTDNCHI--DAICQNTPRSYKCICKSGYTGDGK 66
DV+EC E + + +A C NT SYKC+C GY K
Sbjct: 1663 DVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDK 1702
Score = 32.0 bits (71), Expect = 3.0
Identities = 25/88 (28%), Positives = 32/88 (36%), Gaps = 12/88 (13%)
Query: 337 GSFQCLCHRGYLLYGITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKD 396
G + H+ L G+ CG G C G PGS +CT P+ NG
Sbjct: 151 GGSRLQVHQKQQLQGVNVCG---------GRCCHGWSKAPGSQRCTKPSCVPPCQ-NGGM 200
Query: 397 CTEPLKCQGSPGASKAMLSCNRSGKKDT 424
C P C PG +C +DT
Sbjct: 201 CLRPQLCVCKPGTKGK--ACETIAAQDT 226
>gi|46249412 latent transforming growth factor beta binding protein
1 isoform LTBP-1S [Homo sapiens]
Length = 1396
Score = 203 bits (516), Expect = 7e-52
Identities = 139/423 (32%), Positives = 193/423 (45%), Gaps = 72/423 (17%)
Query: 19 RAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTG--DGKHCKDVDECER 76
R ++ + D+DEC + C C+NT S+ CIC +G+ +G +C DVDEC R
Sbjct: 580 RFSEQQRKCVDIDECTQVQHLCS-QGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLR 638
Query: 77 EDNAG---CVH-------------------------------------DCVNIPGNYRCT 96
D G CV+ CVN PG+Y+C
Sbjct: 639 PDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCV 698
Query: 97 -CYDGFHLAHDGHN--CLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTC-- 151
C +GF G N CLDVDEC E N C N+ GSY C C +G+ + + C
Sbjct: 699 PCTEGFR----GWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRD 754
Query: 152 IQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT--CNYGNGGCQ 209
I ++G C+N C+ T +G C C G++L+ + C+ C + +
Sbjct: 755 IDECQQGNLCVNGQ------CKNT-EGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAH 807
Query: 210 HTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCD-SKCHDAATGVHCTCPVGF 266
C +TE +C C + G C I C + C C + A CTCP GF
Sbjct: 808 GQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGF 867
Query: 267 MLQPDRKTCKDIDECRLNNGGC--DHICRNTVGSFECSCKKGYKLLINERNCQDIDECSF 324
L D KTC+DI+EC + G C C NT GSF C C++G+ + + R C+DIDEC
Sbjct: 868 QLD-DNKTCQDINECE-HPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVN 925
Query: 325 DRTCDH--ICVNTPGSFQCLCHRGYLL-YGITHCGDVDECSINRGGC-RFGCINTPGSYQ 380
+ CD C NT GSF+CLC++G+ C DV+EC + G C C N GS+
Sbjct: 926 NTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFL 985
Query: 381 CTC 383
C C
Sbjct: 986 CVC 988
Score = 194 bits (494), Expect = 3e-49
Identities = 119/384 (30%), Positives = 178/384 (46%), Gaps = 17/384 (4%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGCVHDC 86
+++EC D C C N P Y CIC GY + + C D+DEC + + C
Sbjct: 548 EINECTVNPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRC 606
Query: 87 VNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYEC-HCREGFFLS 145
N G++ C C GF + +G NC+DVDEC + + CVN +G++ C +C G+ ++
Sbjct: 607 ENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMT 666
Query: 146 DNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGN 205
R E+ C+N + C +P C GF Q C N
Sbjct: 667 QR-----GRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPN 721
Query: 206 GGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAATGVHCTCP 263
C + E C CH + D K C I+ C N + +C + CTC
Sbjct: 722 VCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCG 781
Query: 264 VGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECS 323
G+ L + C+DIDEC+ + CRNT GSF+C C +GY+ +C+DI+EC
Sbjct: 782 QGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECL 841
Query: 324 FDRT-CDH-ICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGC--RFGCINTPGSY 379
D++ C C+NT GS+ C C G+ L C D++EC + G C + C+NT GS+
Sbjct: 842 EDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECE-HPGLCGPQGECLNTEGSF 900
Query: 380 QCTCPAGQGRLHWNGKDCTEPLKC 403
C C G + +G+ C + +C
Sbjct: 901 HCVCQQGFS-ISADGRTCEDIDEC 923
Score = 165 bits (417), Expect = 2e-40
Identities = 131/427 (30%), Positives = 182/427 (42%), Gaps = 78/427 (18%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTG--DGKHCKDVDECEREDNAGCVH-D 85
DVDEC+E N + C N SY C C GYT D KHC+D+DEC++ + CV+
Sbjct: 713 DVDECLE--PNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNL--CVNGQ 768
Query: 86 CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLS 145
C N G++RCTC G+ L+ C D+DEC + C N GS++C C +G+ S
Sbjct: 769 CKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRAS 828
Query: 146 DNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQ--RDCKLTCNY 203
C E+ C+ C G C C GF+L N+ +D +
Sbjct: 829 GLGDHC----EDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHP 884
Query: 204 GNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSK--CHDAATGVH 259
G G Q C +TE C C F + DG+TC I+ C VNN CDS C + A
Sbjct: 885 GLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDSHGFCDNTAGSFR 943
Query: 260 CTCPVGFMLQPDRKTCKDIDECRLNNGGC-DHICRNTVGSFECSC---KKGYKLLINE-- 313
C C GF D + C D++EC L +G C + C N GSF C C + Y + +
Sbjct: 944 CLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCR 1003
Query: 314 -RNCQDID-----------ECSFDRT----CDHI---------CVNTPGS--------FQ 340
R D+D EC ++ CD++ C T G+ F
Sbjct: 1004 SRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFP 1063
Query: 341 C----------LCHRGYLLY---------GITHCGDVDECSI-NRGGCRFG-CINTPGSY 379
C +C +G G + D DEC + + C+ G C+NT Y
Sbjct: 1064 CPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGY 1123
Query: 380 QCTCPAG 386
+C C G
Sbjct: 1124 ECYCKQG 1130
Score = 155 bits (391), Expect = 2e-37
Identities = 124/431 (28%), Positives = 182/431 (42%), Gaps = 84/431 (19%)
Query: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGC 82
K +D+DEC +G N ++ C+NT S++C C GY + C+D+DEC+ C
Sbjct: 750 KHCRDIDECQQG--NLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHL--C 805
Query: 83 VH-DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCRE 140
H C N G+++C C G+ + G +C D++EC E CQ+ C+N GSY+C C +
Sbjct: 806 AHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPD 865
Query: 141 GFFLSDNQHTC--IQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCK 198
GF L DN+ TC I E C G C T +G C C+ GF ++ + R C+
Sbjct: 866 GFQLDDNK-TCQDINECEHPGLC-----GPQGECLNT-EGSFHCVCQQGFSISADGRTCE 918
Query: 199 -LTCNYGNGGCQHT--CDDTEQGPRCGCHIKFVLHTDGKTCIET--CAVNNGGC-DSKCH 252
+ N C CD+T RC C+ F DG+ C++ C + +G C ++ C
Sbjct: 919 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCE 978
Query: 253 DAATGVHCTC--------PVGFMLQPDRKTCKDID---------EC--RLNNGG-CDHIC 292
+ C C P+ + T D+D EC LN+ CD++
Sbjct: 979 NVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVL 1038
Query: 293 RNTVGSFECSCKKGYKLLIN-----------------------------------ERNCQ 317
V EC C G N N +
Sbjct: 1039 APNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYK 1098
Query: 318 DIDECSF--DRTCDH-ICVNTPGSFQCLCHRGYLLYGIT-HCGDVDECSINRGGCRFG-C 372
D DEC C + C+NT ++C C +G + C D+DEC + C G C
Sbjct: 1099 DADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQ-DPSSCIDGQC 1157
Query: 373 INTPGSYQCTC 383
+NT GSY C C
Sbjct: 1158 VNTEGSYNCFC 1168
Score = 115 bits (287), Expect = 3e-25
Identities = 90/327 (27%), Positives = 134/327 (40%), Gaps = 51/327 (15%)
Query: 24 SKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAG 81
+K QD++EC E C C NT S+ C+C+ G++ DG+ C+D+DEC
Sbjct: 872 NKTCQDINEC-EHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCD 930
Query: 82 CVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCRE 140
C N G++RC CY GF DG C+DV+EC +G C ++ C N+ GS+ C C +
Sbjct: 931 SHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCAD 990
Query: 141 GFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPK-----------GGIACECRPGFE 189
+NQ P G C ++ + + PK C+
Sbjct: 991 -----ENQE---YSPMTGQ-CRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPN 1041
Query: 190 LTKNQRDCKLTCNYGNGGCQ-------HTCDDTEQGPR---------CGCHIKFVLHTDG 233
+TK + C +G+ C+ T + TE P+ + D
Sbjct: 1042 VTKQECCCTSGAGWGDN-CEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDA 1100
Query: 234 KTCI----ETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCD 289
C+ E C NG C + G C C G P + C D+DEC+ + D
Sbjct: 1101 DECLLFGQEIC--KNGFC----LNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCID 1154
Query: 290 HICRNTVGSFECSCKKGYKLLINERNC 316
C NT GS+ C C L +E+ C
Sbjct: 1155 GQCVNTEGSYNCFCTHPMVLDASEKRC 1181
Score = 85.5 bits (210), Expect = 2e-16
Identities = 75/289 (25%), Positives = 104/289 (35%), Gaps = 43/289 (14%)
Query: 58 KSGYTGDGKHCKDVDECEREDNAGCVHD-CVNIPGNYRCTCYDGFHLAHDGHNCLDVDEC 116
+S G++ KD DEC C + C+N Y C C G + C D+DEC
Sbjct: 1087 ESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDEC 1146
Query: 117 AEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETP 176
+ + CVN GSY C C L ++ CI RP E + + +C E
Sbjct: 1147 QDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCI-RPAESNEQIEETDVYQDLCWEHL 1205
Query: 177 KGGIACECRPGFELTKNQRDCKLTCNYGNG-GCQHTC----DDTEQGPRCGCHIKFVLHT 231
C RP +C C YG G Q D + C +
Sbjct: 1206 SDEYVCS-RPLVGKQTTYTEC--CCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQP 1262
Query: 232 DGKTCI-----------------------------ETCAVNNGGCDSKCHDAATGVHCTC 262
G+ + E C + NG + +C G C C
Sbjct: 1263 YGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDC 1322
Query: 263 PVGFMLQPDRKTCKDIDEC-RLNN--GGCDHI-CRNTVGSFECSCKKGY 307
G+ L + TC D++EC LNN C + C NT GS++C C GY
Sbjct: 1323 FDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGY 1371
Score = 80.5 bits (197), Expect = 7e-15
Identities = 114/458 (24%), Positives = 155/458 (33%), Gaps = 98/458 (21%)
Query: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTG--DGKHCKDVDECEREDNAGC 82
+ +D+DECV T C C NT S++C+C G+ DG+ C DV+ECE
Sbjct: 915 RTCEDIDECVNNTV-CDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCG 973
Query: 83 VHDCVNIPGNYRCTCYD-GFHLAHDGHNC---------LDVDECAEGNGGCQQS------ 126
C N+ G++ C C D + C +DVD+ E C +
Sbjct: 974 EAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASL 1033
Query: 127 CVNMMG----SYECHCREGFFLSDN--------------QHTC------IQRPEEGMNCM 162
C N++ EC C G DN C + E
Sbjct: 1034 CDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAG 1093
Query: 163 NKNHGCAHIC----RETPKGGIACECRPGFELTKNQRD----CKLTCNYGNGGCQHT--- 211
+N+ A C +E K G RPG+E Q KL C + CQ
Sbjct: 1094 GENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQC-FDMDECQDPSSC 1152
Query: 212 ----CDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHD-------------- 253
C +TE C C VL K CI N ++ +
Sbjct: 1153 IDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCS 1212
Query: 254 ------AATGVHCTCPVGFMLQPDRKTC--KDIDE----CRLN-NGGCDHICRNTVGSF- 299
T C C G C KD D+ C + G R+ + F
Sbjct: 1213 RPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFS 1272
Query: 300 ECSCKKGYKLLINERNCQDI-----DECSFDRTCDH-ICVNTPGSFQCLCHRGYLL-YGI 352
E + I +R +EC C++ CV + C C GY L
Sbjct: 1273 EQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAK 1332
Query: 353 THCGDVDECS--INRGG-CRFG-CINTPGSYQCTCPAG 386
C DV+EC NR C+ CINT GSY+C C G
Sbjct: 1333 MTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPG 1370
Score = 60.8 bits (146), Expect = 6e-09
Identities = 30/76 (39%), Positives = 42/76 (55%), Gaps = 5/76 (6%)
Query: 81 GCVHD-CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGG---CQQS-CVNMMGSYE 135
GC + CV + Y C C+DG+HL C+DV+EC E N C+ + C+N GSY+
Sbjct: 1305 GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYK 1364
Query: 136 CHCREGFFLSDNQHTC 151
C C G+ SD + C
Sbjct: 1365 CLCLPGYVPSDKPNYC 1380
Score = 44.7 bits (104), Expect = 4e-04
Identities = 22/47 (46%), Positives = 28/47 (59%), Gaps = 2/47 (4%)
Query: 343 CHRGYLLYGITHCGDVDECSINRGGCRFG-CINTPGSYQCTCPAGQG 388
C GY T C D++EC + +G C G C+NT GSY+CTC G G
Sbjct: 286 CLPGYKRVNNTFCQDINECQL-QGVCPNGECLNTMGSYRCTCKIGFG 331
Score = 43.5 bits (101), Expect = 0.001
Identities = 20/46 (43%), Positives = 27/46 (58%), Gaps = 2/46 (4%)
Query: 303 CKKGYKLLINERNCQDIDECSFDRTCDH-ICVNTPGSFQCLCHRGY 347
C GYK +N CQDI+EC C + C+NT GS++C C G+
Sbjct: 286 CLPGYKR-VNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 330
Score = 38.9 bits (89), Expect = 0.024
Identities = 15/33 (45%), Positives = 23/33 (69%)
Query: 275 CKDIDECRLNNGGCDHICRNTVGSFECSCKKGY 307
C+DI+EC+L + C NT+GS+ C+CK G+
Sbjct: 298 CQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 330
Score = 38.5 bits (88), Expect = 0.032
Identities = 21/65 (32%), Positives = 31/65 (47%), Gaps = 3/65 (4%)
Query: 92 NYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFLSDNQHT 150
N C G+ ++ C D++EC + G C C+N MGSY C C+ GF +
Sbjct: 281 NQMMECLPGYKRVNNTF-CQDINEC-QLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSS 338
Query: 151 CIQRP 155
C+ P
Sbjct: 339 CVPDP 343
Score = 37.4 bits (85), Expect = 0.070
Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 5/70 (7%)
Query: 57 CKSGYTG-DGKHCKDVDECEREDNAGCVH-DCVNIPGNYRCTCYDGFHLAHDGHNCL-DV 113
C GY + C+D++EC+ + C + +C+N G+YRCTC GF +C+ D
Sbjct: 286 CLPGYKRVNNTFCQDINECQLQ--GVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDP 343
Query: 114 DECAEGNGGC 123
+E G C
Sbjct: 344 PVISEEKGPC 353
Score = 33.5 bits (75), Expect = 1.0
Identities = 17/40 (42%), Positives = 22/40 (55%), Gaps = 2/40 (5%)
Query: 29 DVDECVEGTDNCHI--DAICQNTPRSYKCICKSGYTGDGK 66
DV+EC E + + +A C NT SYKC+C GY K
Sbjct: 1337 DVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDK 1376
>gi|34734066 fibulin 1 isoform D [Homo sapiens]
Length = 703
Score = 197 bits (501), Expect = 4e-50
Identities = 134/402 (33%), Positives = 192/402 (47%), Gaps = 46/402 (11%)
Query: 82 CVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMGSYECH-- 137
C C + C+C+ G+ L DG +C DV+EC G+ C+ +SC+N +GS+ C
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 138 --CREGFFLS-DNQHTCIQRPEEGMNCMNKNHGCA--HICRETPKGGIAC----ECRPGF 188
C G+ L+ DN I E G+ H C IC+ T G C +C+ GF
Sbjct: 246 SSCGTGYELTEDNSCKDIDECESGI------HNCLPDFICQNT-LGSFRCRPKLQCKSGF 298
Query: 189 --ELTKNQRDCKLTCNYGNGGCQ--HTCDDTEQGPRC-----GCHIKFVLHTDGKTCIET 239
+ N D C + C HTC +TE C C + L+ +G C++
Sbjct: 299 IQDALGNCIDIN-ECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV 357
Query: 240 --CAVNNGGCDS--KCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGG-CDHICRN 294
CA C +C ++ C C G+ + C D++EC+ G C H C N
Sbjct: 358 DECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
Query: 295 TVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLY---G 351
T+GS+ CSC G++L ++ R+C+DI+ECS C C N GS+QC C RGY L G
Sbjct: 418 TLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPCSQECANVYGSYQCYCRRGYQLSDVDG 476
Query: 352 ITHCGDVDECSINRGG--CRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKC-QGSPG 408
+T C D+DEC++ GG C + CIN PGS+QC+CP+ RL NG++C + +C G
Sbjct: 477 VT-CEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHN 535
Query: 409 ASKAMLSCNRSGKKDTCALTCPS---RARFLPESENGFTVSC 447
S N G A CP R+ + E TV C
Sbjct: 536 CSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRC 577
Score = 188 bits (478), Expect = 2e-47
Identities = 118/347 (34%), Positives = 167/347 (48%), Gaps = 37/347 (10%)
Query: 26 AAQDVDECVEGTDNCHIDAICQNTPRSYKC----ICKSGY-TGDGKHCKDVDECEREDNA 80
+ +DV+EC+ G+ +C + C NT S++C C +GY + CKD+DECE +
Sbjct: 213 SCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH- 271
Query: 81 GCVHD--CVNIPGNYRC----TCYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMG 132
C+ D C N G++RC C GF G NC+D++EC + C +C+N G
Sbjct: 272 NCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEG 330
Query: 133 SYEC-----HCREGFFLSDNQHTCIQRPEEGMNCMNKNHGC--AHICRETPKGGIACECR 185
SY C +C G+ L++ C+ E C C H C +P G CEC+
Sbjct: 331 SYTCQKNVPNCGRGYHLNEEGTRCVDVDE----CAPPAEPCGKGHRCVNSP-GSFRCECK 385
Query: 186 PGFELTKNQRDC---KLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAV 242
G+ R C Y C H C++T C C + F L DG++C +
Sbjct: 386 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC 445
Query: 243 NNGGCDSKCHDAATGVHCTCPVGFMLQP-DRKTCKDIDECRLNNGG--CDHICRNTVGSF 299
++ C +C + C C G+ L D TC+DIDEC L GG C + C N GSF
Sbjct: 446 SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSF 505
Query: 300 ECSC-KKGYKLLINERNCQDIDEC---SFDRTCDHICVNTPGSFQCL 342
+CSC GY+L N RNCQDIDEC + + + C N G F+CL
Sbjct: 506 QCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
Score = 168 bits (426), Expect = 2e-41
Identities = 110/340 (32%), Positives = 155/340 (45%), Gaps = 35/340 (10%)
Query: 26 AAQDVDECVEGTDNCHIDAICQNTPRSYKC----ICKSGYTGDG-KHCKDVDECEREDNA 80
+ +D+DEC G NC D ICQNT S++C CKSG+ D +C D++EC +A
Sbjct: 259 SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINEC-LSISA 317
Query: 81 GCV--HDCVNIPGNYRC-----TCYDGFHLAHDGHNCLDVDECAEGNGGCQQS--CVNMM 131
C H C+N G+Y C C G+HL +G C+DVDECA C + CVN
Sbjct: 318 PCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSP 377
Query: 132 GSYECHCREGFFLSDNQHTCIQRPEEGMNCMN-KNHGCAHICRETPKGGIACECRPGFEL 190
GS+ C C+ G++ C+ E C C H C T G C C GF L
Sbjct: 378 GSFRCECKTGYYFDGISRMCVDVNE----CQRYPGRLCGHKCENT-LGSYLCSCSVGFRL 432
Query: 191 TKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVL-HTDGKTC--IETCAVNNGG- 246
+ + R C+ + C C + +C C + L DG TC I+ CA+ GG
Sbjct: 433 SVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGH 492
Query: 247 -CDSKCHDAATGVHCTCP-VGFMLQPDRKTCKDIDEC--RLNNGGCDHICRNTVGSFEC- 301
C +C + C+CP G+ L P+ + C+DIDEC ++N + C N G F C
Sbjct: 493 ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
Query: 302 --SCKKGYKLLINERNCQDIDECSFDRTC---DHICVNTP 336
C + Y+ + D ++C D CV P
Sbjct: 553 AFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDP 592
Score = 112 bits (279), Expect = 2e-24
Identities = 101/342 (29%), Positives = 138/342 (40%), Gaps = 53/342 (15%)
Query: 97 CYDGFHLAHDGHNC-----LDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTC 151
C DG +A +C + EC C S + E HC G L++ Q C
Sbjct: 37 CADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLE-----ELHCATGISLANEQDRC 91
Query: 152 IQRPEEGMNC-MNKNHGCAHIC---RETPKGGIACE--CRPGFELTKNQRDCKL----TC 201
+ + C H C R G +CE G++ + R C + T
Sbjct: 92 ATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETG 151
Query: 202 NYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCT 261
+ GG Q T E V + G C +C D V C+
Sbjct: 152 DLDVGGLQETDKIIE-----------VEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCS 200
Query: 262 CPVGFMLQPDRKTCKDIDECRLNNGGC--DHICRNTVGSFEC----SCKKGYKLLINERN 315
C VG+ L D +C+D++EC + C C NTVGSF C SC GY+ L + +
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYE-LTEDNS 259
Query: 316 CQDIDEC-SFDRTC--DHICVNTPGSFQC----LCHRGYLLYGITHCGDVDECSINRGGC 368
C+DIDEC S C D IC NT GSF+C C G++ + +C D++EC C
Sbjct: 260 CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPC 319
Query: 369 RFG--CINTPGSYQC-----TCPAGQGRLHWNGKDCTEPLKC 403
G CINT GSY C C G L+ G C + +C
Sbjct: 320 PIGHTCINTEGSYTCQKNVPNCGRGY-HLNEEGTRCVDVDEC 360
Score = 42.4 bits (98), Expect = 0.002
Identities = 25/87 (28%), Positives = 36/87 (41%), Gaps = 10/87 (11%)
Query: 19 RAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCI---CKSGYTGDGKHCKDVDECE 75
R A + QD+DECV G NC I+ C N ++C+ C Y + E
Sbjct: 515 RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQ----E 570
Query: 76 REDNAGCVHDCVNIPGNYRCTCYDGFH 102
+ D C+ C P + C +D H
Sbjct: 571 KTDTVRCIKSC--RPNDVTCV-FDPVH 594
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 197 bits (500), Expect = 5e-50
Identities = 130/386 (33%), Positives = 186/386 (48%), Gaps = 43/386 (11%)
Query: 82 CVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMGSYECH-- 137
C C + C+C+ G+ L DG +C DV+EC G+ C+ +SC+N +GS+ C
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 138 --CREGFFLS-DNQHTCIQRPEEGMNCMNKNHGCA--HICRETPKGGIAC----ECRPGF 188
C G+ L+ DN I E G+ H C IC+ T G C +C+ GF
Sbjct: 246 SSCGTGYELTEDNSCKDIDECESGI------HNCLPDFICQNT-LGSFRCRPKLQCKSGF 298
Query: 189 --ELTKNQRDCKLTCNYGNGGCQ--HTCDDTEQGPRC-----GCHIKFVLHTDGKTCIET 239
+ N D C + C HTC +TE C C + L+ +G C++
Sbjct: 299 IQDALGNCIDIN-ECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV 357
Query: 240 --CAVNNGGCDS--KCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGG-CDHICRN 294
CA C +C ++ C C G+ + C D++EC+ G C H C N
Sbjct: 358 DECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
Query: 295 TVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLY---G 351
T+GS+ CSC G++L ++ R+C+DI+ECS C C N GS+QC C RGY L G
Sbjct: 418 TLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPCSQECANVYGSYQCYCRRGYQLSDVDG 476
Query: 352 ITHCGDVDECSINRGG--CRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKC-QGSPG 408
+T C D+DEC++ GG C + CIN PGS+QC+CP+ RL NG++C + +C G
Sbjct: 477 VT-CEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHN 535
Query: 409 ASKAMLSCNRSGKKDTCALTCPSRAR 434
S N G A CP R
Sbjct: 536 CSINETCFNIQGGFRCLAFECPENYR 561
Score = 188 bits (478), Expect = 2e-47
Identities = 118/347 (34%), Positives = 167/347 (48%), Gaps = 37/347 (10%)
Query: 26 AAQDVDECVEGTDNCHIDAICQNTPRSYKC----ICKSGY-TGDGKHCKDVDECEREDNA 80
+ +DV+EC+ G+ +C + C NT S++C C +GY + CKD+DECE +
Sbjct: 213 SCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH- 271
Query: 81 GCVHD--CVNIPGNYRC----TCYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMG 132
C+ D C N G++RC C GF G NC+D++EC + C +C+N G
Sbjct: 272 NCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEG 330
Query: 133 SYEC-----HCREGFFLSDNQHTCIQRPEEGMNCMNKNHGC--AHICRETPKGGIACECR 185
SY C +C G+ L++ C+ E C C H C +P G CEC+
Sbjct: 331 SYTCQKNVPNCGRGYHLNEEGTRCVDVDE----CAPPAEPCGKGHRCVNSP-GSFRCECK 385
Query: 186 PGFELTKNQRDC---KLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAV 242
G+ R C Y C H C++T C C + F L DG++C +
Sbjct: 386 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC 445
Query: 243 NNGGCDSKCHDAATGVHCTCPVGFMLQP-DRKTCKDIDECRLNNGG--CDHICRNTVGSF 299
++ C +C + C C G+ L D TC+DIDEC L GG C + C N GSF
Sbjct: 446 SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSF 505
Query: 300 ECSC-KKGYKLLINERNCQDIDEC---SFDRTCDHICVNTPGSFQCL 342
+CSC GY+L N RNCQDIDEC + + + C N G F+CL
Sbjct: 506 QCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
Score = 168 bits (425), Expect = 3e-41
Identities = 104/309 (33%), Positives = 146/309 (47%), Gaps = 32/309 (10%)
Query: 26 AAQDVDECVEGTDNCHIDAICQNTPRSYKC----ICKSGYTGDG-KHCKDVDECEREDNA 80
+ +D+DEC G NC D ICQNT S++C CKSG+ D +C D++EC +A
Sbjct: 259 SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINEC-LSISA 317
Query: 81 GCV--HDCVNIPGNYRC-----TCYDGFHLAHDGHNCLDVDECAEGNGGCQQS--CVNMM 131
C H C+N G+Y C C G+HL +G C+DVDECA C + CVN
Sbjct: 318 PCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSP 377
Query: 132 GSYECHCREGFFLSDNQHTCIQRPEEGMNCMN-KNHGCAHICRETPKGGIACECRPGFEL 190
GS+ C C+ G++ C+ E C C H C T G C C GF L
Sbjct: 378 GSFRCECKTGYYFDGISRMCVDVNE----CQRYPGRLCGHKCENT-LGSYLCSCSVGFRL 432
Query: 191 TKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVL-HTDGKTC--IETCAVNNGG- 246
+ + R C+ + C C + +C C + L DG TC I+ CA+ GG
Sbjct: 433 SVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGH 492
Query: 247 -CDSKCHDAATGVHCTCP-VGFMLQPDRKTCKDIDEC--RLNNGGCDHICRNTVGSFEC- 301
C +C + C+CP G+ L P+ + C+DIDEC ++N + C N G F C
Sbjct: 493 ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
Query: 302 --SCKKGYK 308
C + Y+
Sbjct: 553 AFECPENYR 561
Score = 112 bits (279), Expect = 2e-24
Identities = 101/342 (29%), Positives = 138/342 (40%), Gaps = 53/342 (15%)
Query: 97 CYDGFHLAHDGHNC-----LDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTC 151
C DG +A +C + EC C S + E HC G L++ Q C
Sbjct: 37 CADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLE-----ELHCATGISLANEQDRC 91
Query: 152 IQRPEEGMNC-MNKNHGCAHIC---RETPKGGIACE--CRPGFELTKNQRDCKL----TC 201
+ + C H C R G +CE G++ + R C + T
Sbjct: 92 ATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETG 151
Query: 202 NYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCT 261
+ GG Q T E V + G C +C D V C+
Sbjct: 152 DLDVGGLQETDKIIE-----------VEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCS 200
Query: 262 CPVGFMLQPDRKTCKDIDECRLNNGGC--DHICRNTVGSFEC----SCKKGYKLLINERN 315
C VG+ L D +C+D++EC + C C NTVGSF C SC GY+ L + +
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYE-LTEDNS 259
Query: 316 CQDIDEC-SFDRTC--DHICVNTPGSFQC----LCHRGYLLYGITHCGDVDECSINRGGC 368
C+DIDEC S C D IC NT GSF+C C G++ + +C D++EC C
Sbjct: 260 CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPC 319
Query: 369 RFG--CINTPGSYQC-----TCPAGQGRLHWNGKDCTEPLKC 403
G CINT GSY C C G L+ G C + +C
Sbjct: 320 PIGHTCINTEGSYTCQKNVPNCGRGY-HLNEEGTRCVDVDEC 360
Score = 38.9 bits (89), Expect = 0.024
Identities = 21/75 (28%), Positives = 29/75 (38%), Gaps = 3/75 (4%)
Query: 19 RAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCI---CKSGYTGDGKHCKDVDECE 75
R A + QD+DECV G NC I+ C N ++C+ C Y K +
Sbjct: 515 RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQ 574
Query: 76 REDNAGCVHDCVNIP 90
DC +P
Sbjct: 575 NTPAGSSKEDCRVLP 589
>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
Length = 566
Score = 197 bits (500), Expect = 5e-50
Identities = 130/386 (33%), Positives = 186/386 (48%), Gaps = 43/386 (11%)
Query: 82 CVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMGSYECH-- 137
C C + C+C+ G+ L DG +C DV+EC G+ C+ +SC+N +GS+ C
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 138 --CREGFFLS-DNQHTCIQRPEEGMNCMNKNHGCA--HICRETPKGGIAC----ECRPGF 188
C G+ L+ DN I E G+ H C IC+ T G C +C+ GF
Sbjct: 246 SSCGTGYELTEDNSCKDIDECESGI------HNCLPDFICQNT-LGSFRCRPKLQCKSGF 298
Query: 189 --ELTKNQRDCKLTCNYGNGGCQ--HTCDDTEQGPRC-----GCHIKFVLHTDGKTCIET 239
+ N D C + C HTC +TE C C + L+ +G C++
Sbjct: 299 IQDALGNCIDIN-ECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV 357
Query: 240 --CAVNNGGCDS--KCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGG-CDHICRN 294
CA C +C ++ C C G+ + C D++EC+ G C H C N
Sbjct: 358 DECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
Query: 295 TVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLY---G 351
T+GS+ CSC G++L ++ R+C+DI+ECS C C N GS+QC C RGY L G
Sbjct: 418 TLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPCSQECANVYGSYQCYCRRGYQLSDVDG 476
Query: 352 ITHCGDVDECSINRGG--CRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKC-QGSPG 408
+T C D+DEC++ GG C + CIN PGS+QC+CP+ RL NG++C + +C G
Sbjct: 477 VT-CEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHN 535
Query: 409 ASKAMLSCNRSGKKDTCALTCPSRAR 434
S N G A CP R
Sbjct: 536 CSINETCFNIQGGFRCLAFECPENYR 561
Score = 188 bits (478), Expect = 2e-47
Identities = 118/347 (34%), Positives = 167/347 (48%), Gaps = 37/347 (10%)
Query: 26 AAQDVDECVEGTDNCHIDAICQNTPRSYKC----ICKSGY-TGDGKHCKDVDECEREDNA 80
+ +DV+EC+ G+ +C + C NT S++C C +GY + CKD+DECE +
Sbjct: 213 SCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH- 271
Query: 81 GCVHD--CVNIPGNYRC----TCYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMG 132
C+ D C N G++RC C GF G NC+D++EC + C +C+N G
Sbjct: 272 NCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEG 330
Query: 133 SYEC-----HCREGFFLSDNQHTCIQRPEEGMNCMNKNHGC--AHICRETPKGGIACECR 185
SY C +C G+ L++ C+ E C C H C +P G CEC+
Sbjct: 331 SYTCQKNVPNCGRGYHLNEEGTRCVDVDE----CAPPAEPCGKGHRCVNSP-GSFRCECK 385
Query: 186 PGFELTKNQRDC---KLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAV 242
G+ R C Y C H C++T C C + F L DG++C +
Sbjct: 386 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC 445
Query: 243 NNGGCDSKCHDAATGVHCTCPVGFMLQP-DRKTCKDIDECRLNNGG--CDHICRNTVGSF 299
++ C +C + C C G+ L D TC+DIDEC L GG C + C N GSF
Sbjct: 446 SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSF 505
Query: 300 ECSC-KKGYKLLINERNCQDIDEC---SFDRTCDHICVNTPGSFQCL 342
+CSC GY+L N RNCQDIDEC + + + C N G F+CL
Sbjct: 506 QCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
Score = 168 bits (425), Expect = 3e-41
Identities = 104/309 (33%), Positives = 146/309 (47%), Gaps = 32/309 (10%)
Query: 26 AAQDVDECVEGTDNCHIDAICQNTPRSYKC----ICKSGYTGDG-KHCKDVDECEREDNA 80
+ +D+DEC G NC D ICQNT S++C CKSG+ D +C D++EC +A
Sbjct: 259 SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINEC-LSISA 317
Query: 81 GCV--HDCVNIPGNYRC-----TCYDGFHLAHDGHNCLDVDECAEGNGGCQQS--CVNMM 131
C H C+N G+Y C C G+HL +G C+DVDECA C + CVN
Sbjct: 318 PCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSP 377
Query: 132 GSYECHCREGFFLSDNQHTCIQRPEEGMNCMN-KNHGCAHICRETPKGGIACECRPGFEL 190
GS+ C C+ G++ C+ E C C H C T G C C GF L
Sbjct: 378 GSFRCECKTGYYFDGISRMCVDVNE----CQRYPGRLCGHKCENT-LGSYLCSCSVGFRL 432
Query: 191 TKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVL-HTDGKTC--IETCAVNNGG- 246
+ + R C+ + C C + +C C + L DG TC I+ CA+ GG
Sbjct: 433 SVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGH 492
Query: 247 -CDSKCHDAATGVHCTCP-VGFMLQPDRKTCKDIDEC--RLNNGGCDHICRNTVGSFEC- 301
C +C + C+CP G+ L P+ + C+DIDEC ++N + C N G F C
Sbjct: 493 ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
Query: 302 --SCKKGYK 308
C + Y+
Sbjct: 553 AFECPENYR 561
Score = 112 bits (279), Expect = 2e-24
Identities = 101/342 (29%), Positives = 138/342 (40%), Gaps = 53/342 (15%)
Query: 97 CYDGFHLAHDGHNC-----LDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTC 151
C DG +A +C + EC C S + E HC G L++ Q C
Sbjct: 37 CADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLE-----ELHCATGISLANEQDRC 91
Query: 152 IQRPEEGMNC-MNKNHGCAHIC---RETPKGGIACE--CRPGFELTKNQRDCKL----TC 201
+ + C H C R G +CE G++ + R C + T
Sbjct: 92 ATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETG 151
Query: 202 NYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCT 261
+ GG Q T E V + G C +C D V C+
Sbjct: 152 DLDVGGLQETDKIIE-----------VEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCS 200
Query: 262 CPVGFMLQPDRKTCKDIDECRLNNGGC--DHICRNTVGSFEC----SCKKGYKLLINERN 315
C VG+ L D +C+D++EC + C C NTVGSF C SC GY+ L + +
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYE-LTEDNS 259
Query: 316 CQDIDEC-SFDRTC--DHICVNTPGSFQC----LCHRGYLLYGITHCGDVDECSINRGGC 368
C+DIDEC S C D IC NT GSF+C C G++ + +C D++EC C
Sbjct: 260 CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPC 319
Query: 369 RFG--CINTPGSYQC-----TCPAGQGRLHWNGKDCTEPLKC 403
G CINT GSY C C G L+ G C + +C
Sbjct: 320 PIGHTCINTEGSYTCQKNVPNCGRGY-HLNEEGTRCVDVDEC 360
Score = 38.5 bits (88), Expect = 0.032
Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 3/46 (6%)
Query: 19 RAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCI---CKSGY 61
R A + QD+DECV G NC I+ C N ++C+ C Y
Sbjct: 515 RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
Length = 683
Score = 197 bits (500), Expect = 5e-50
Identities = 130/386 (33%), Positives = 186/386 (48%), Gaps = 43/386 (11%)
Query: 82 CVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMGSYECH-- 137
C C + C+C+ G+ L DG +C DV+EC G+ C+ +SC+N +GS+ C
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 138 --CREGFFLS-DNQHTCIQRPEEGMNCMNKNHGCA--HICRETPKGGIAC----ECRPGF 188
C G+ L+ DN I E G+ H C IC+ T G C +C+ GF
Sbjct: 246 SSCGTGYELTEDNSCKDIDECESGI------HNCLPDFICQNT-LGSFRCRPKLQCKSGF 298
Query: 189 --ELTKNQRDCKLTCNYGNGGCQ--HTCDDTEQGPRC-----GCHIKFVLHTDGKTCIET 239
+ N D C + C HTC +TE C C + L+ +G C++
Sbjct: 299 IQDALGNCIDIN-ECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDV 357
Query: 240 --CAVNNGGCDS--KCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGG-CDHICRN 294
CA C +C ++ C C G+ + C D++EC+ G C H C N
Sbjct: 358 DECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCEN 417
Query: 295 TVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLY---G 351
T+GS+ CSC G++L ++ R+C+DI+ECS C C N GS+QC C RGY L G
Sbjct: 418 TLGSYLCSCSVGFRLSVDGRSCEDINECS-SSPCSQECANVYGSYQCYCRRGYQLSDVDG 476
Query: 352 ITHCGDVDECSINRGG--CRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKC-QGSPG 408
+T C D+DEC++ GG C + CIN PGS+QC+CP+ RL NG++C + +C G
Sbjct: 477 VT-CEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHN 535
Query: 409 ASKAMLSCNRSGKKDTCALTCPSRAR 434
S N G A CP R
Sbjct: 536 CSINETCFNIQGGFRCLAFECPENYR 561
Score = 191 bits (485), Expect = 3e-48
Identities = 122/363 (33%), Positives = 171/363 (47%), Gaps = 40/363 (11%)
Query: 26 AAQDVDECVEGTDNCHIDAICQNTPRSYKC----ICKSGY-TGDGKHCKDVDECEREDNA 80
+ +DV+EC+ G+ +C + C NT S++C C +GY + CKD+DECE +
Sbjct: 213 SCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIH- 271
Query: 81 GCVHD--CVNIPGNYRC----TCYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMG 132
C+ D C N G++RC C GF G NC+D++EC + C +C+N G
Sbjct: 272 NCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG-NCIDINECLSISAPCPIGHTCINTEG 330
Query: 133 SYEC-----HCREGFFLSDNQHTCIQRPEEGMNCMNKNHGC--AHICRETPKGGIACECR 185
SY C +C G+ L++ C+ E C C H C +P G CEC+
Sbjct: 331 SYTCQKNVPNCGRGYHLNEEGTRCVDVDE----CAPPAEPCGKGHRCVNSP-GSFRCECK 385
Query: 186 PGFELTKNQRDC---KLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAV 242
G+ R C Y C H C++T C C + F L DG++C +
Sbjct: 386 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINEC 445
Query: 243 NNGGCDSKCHDAATGVHCTCPVGFMLQP-DRKTCKDIDECRLNNGG--CDHICRNTVGSF 299
++ C +C + C C G+ L D TC+DIDEC L GG C + C N GSF
Sbjct: 446 SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSF 505
Query: 300 ECSC-KKGYKLLINERNCQDIDEC---SFDRTCDHICVNTPGSFQCL---CHRGYLLYGI 352
+CSC GY+L N RNCQDIDEC + + + C N G F+CL C Y
Sbjct: 506 QCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAA 565
Query: 353 THC 355
T C
Sbjct: 566 TRC 568
Score = 169 bits (429), Expect = 9e-42
Identities = 109/328 (33%), Positives = 152/328 (46%), Gaps = 36/328 (10%)
Query: 26 AAQDVDECVEGTDNCHIDAICQNTPRSYKC----ICKSGYTGDG-KHCKDVDECEREDNA 80
+ +D+DEC G NC D ICQNT S++C CKSG+ D +C D++EC +A
Sbjct: 259 SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINEC-LSISA 317
Query: 81 GCV--HDCVNIPGNYRC-----TCYDGFHLAHDGHNCLDVDECAEGNGGCQQS--CVNMM 131
C H C+N G+Y C C G+HL +G C+DVDECA C + CVN
Sbjct: 318 PCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSP 377
Query: 132 GSYECHCREGFFLSDNQHTCIQRPEEGMNCMN-KNHGCAHICRETPKGGIACECRPGFEL 190
GS+ C C+ G++ C+ E C C H C T G C C GF L
Sbjct: 378 GSFRCECKTGYYFDGISRMCVDVNE----CQRYPGRLCGHKCENT-LGSYLCSCSVGFRL 432
Query: 191 TKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVL-HTDGKTC--IETCAVNNGG- 246
+ + R C+ + C C + +C C + L DG TC I+ CA+ GG
Sbjct: 433 SVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGH 492
Query: 247 -CDSKCHDAATGVHCTCP-VGFMLQPDRKTCKDIDEC--RLNNGGCDHICRNTVGSFEC- 301
C +C + C+CP G+ L P+ + C+DIDEC ++N + C N G F C
Sbjct: 493 ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
Query: 302 --SCKKGYKLLINER----NCQDIDECS 323
C + Y+ R C + ECS
Sbjct: 553 AFECPENYRRSAATRCERLPCHENRECS 580
Score = 112 bits (279), Expect = 2e-24
Identities = 101/342 (29%), Positives = 138/342 (40%), Gaps = 53/342 (15%)
Query: 97 CYDGFHLAHDGHNC-----LDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTC 151
C DG +A +C + EC C S + E HC G L++ Q C
Sbjct: 37 CADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLE-----ELHCATGISLANEQDRC 91
Query: 152 IQRPEEGMNC-MNKNHGCAHIC---RETPKGGIACE--CRPGFELTKNQRDCKL----TC 201
+ + C H C R G +CE G++ + R C + T
Sbjct: 92 ATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETG 151
Query: 202 NYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCT 261
+ GG Q T E V + G C +C D V C+
Sbjct: 152 DLDVGGLQETDKIIE-----------VEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCS 200
Query: 262 CPVGFMLQPDRKTCKDIDECRLNNGGC--DHICRNTVGSFEC----SCKKGYKLLINERN 315
C VG+ L D +C+D++EC + C C NTVGSF C SC GY+ L + +
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYE-LTEDNS 259
Query: 316 CQDIDEC-SFDRTC--DHICVNTPGSFQC----LCHRGYLLYGITHCGDVDECSINRGGC 368
C+DIDEC S C D IC NT GSF+C C G++ + +C D++EC C
Sbjct: 260 CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPC 319
Query: 369 RFG--CINTPGSYQC-----TCPAGQGRLHWNGKDCTEPLKC 403
G CINT GSY C C G L+ G C + +C
Sbjct: 320 PIGHTCINTEGSYTCQKNVPNCGRGY-HLNEEGTRCVDVDEC 360
Score = 38.5 bits (88), Expect = 0.032
Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 3/46 (6%)
Query: 19 RAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCI---CKSGY 61
R A + QD+DECV G NC I+ C N ++C+ C Y
Sbjct: 515 RLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
>gi|4557733 latent transforming growth factor beta binding protein 2
[Homo sapiens]
Length = 1821
Score = 196 bits (497), Expect = 1e-49
Identities = 133/447 (29%), Positives = 196/447 (43%), Gaps = 62/447 (13%)
Query: 30 VDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAGCVHDCV 87
+D C G N C N P Y+C+C GY +C D +EC R+ G C+
Sbjct: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKG-KGRCI 903
Query: 88 NIPGNYRCTCYDGFHLAHDG--HNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLS 145
N G+Y C CY G+ LA G C D++EC + C N GSY C C +G+ +
Sbjct: 904 NRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMV 963
Query: 146 DNQH----------------TCIQRP--------EEGM-----NCMNKNH-----GCAHI 171
H C+ P EEG +C++ N CAH
Sbjct: 964 RKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHG 1023
Query: 172 CRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHT--CDDTEQGPRC-GCHIKFV 228
+G C C G+E+T +++ C+ + T C +TE C C +
Sbjct: 1024 KCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYW 1083
Query: 229 LHTDGKTC--IETCAVNNGGCDSKCHDAATGVHC-TCPVGFMLQPDRKTCKDIDECRLNN 285
++ DG C ++ CA C + A C C G+ P +C+D+DEC
Sbjct: 1084 VNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQ 1143
Query: 286 GGC-DHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTC--DHICVNTPGSFQCL 342
C C+NTVGS++C C +G++ L N C+D++EC + C C+N+ GSF CL
Sbjct: 1144 SSCLGGECKNTVGSYQCLCPQGFQ-LANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCL 1202
Query: 343 CHRGYL-LYGITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNG------- 394
C G++ G T C DVDEC+ C+NT GS+ C C G +G
Sbjct: 1203 CAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDE 1262
Query: 395 -KDCTEPL----KCQGSPGASKAMLSC 416
+D +P+ KC+ SPG+ + +L C
Sbjct: 1263 CEDYGDPVCGTWKCENSPGSYRCVLGC 1289
Score = 166 bits (421), Expect = 8e-41
Identities = 124/412 (30%), Positives = 172/412 (41%), Gaps = 61/412 (14%)
Query: 86 CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLS 145
CVN+P YRC C G+ L C D +EC + C+N +GSY C C G+ L+
Sbjct: 861 CVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLA 920
Query: 146 DNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTK-----NQRDCKLT 200
+ T Q ++ C C T +G CEC G+ + + + +C+
Sbjct: 921 TSGAT--QECQDINECEQPGVCSGGQCTNT-EGSYHCECDQGYIMVRKGHCQDINECRHP 977
Query: 201 CNYGNGGC-----QHTCDDTEQGPRCGCHIKFVLHTDGKTCIET--CAVNNGGCDSKCHD 253
+G C +TC E+G R +C++ C KC +
Sbjct: 978 GTCPDGRCVNSPGSYTCLACEEGYR----------GQSGSCVDVNECLTPGVCAHGKCTN 1027
Query: 254 AATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECS-CKKGYKLLIN 312
C+C G+ + D K C+D+DEC +C NT GSF CS C+ GY + +
Sbjct: 1028 LEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNED 1087
Query: 313 ERNCQDIDECSFDRTC-DHICVNTPGSFQCL-CHRGYLLYGI-THCGDVDECSINRGGCR 369
C+D+DEC+F C +C NT GSF C C GY + C DVDEC + C
Sbjct: 1088 GTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCL 1147
Query: 370 FG-CINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQG---------------------SP 407
G C NT GSYQC CP QG NG C + +C G +P
Sbjct: 1148 GGECKNTVGSYQCLCP--QGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAP 1205
Query: 408 G--ASKAMLSCNRSGKKDTCALTCPSRARFLPESENGFTVSCGT---PSPRA 454
G +++ SC D CA T P +E F C T PSP +
Sbjct: 1206 GFVSAEGGTSCQ---DVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPES 1254
Score = 133 bits (334), Expect = 9e-31
Identities = 121/439 (27%), Positives = 167/439 (38%), Gaps = 84/439 (19%)
Query: 19 RAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT-GDGKHCKDVDECERE 77
R + + +DVDEC + +C + C+NT SY+C+C G+ +G C+DV+EC E
Sbjct: 1125 RPSPLGDSCEDVDECEDPQSSC-LGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGE 1183
Query: 78 DNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECH 137
++ +C+N G++ C C GF A G +C DVDECA + CVN GS+ C
Sbjct: 1184 EHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCL 1243
Query: 138 CREGFFLSDNQHTCIQRPEEGMNCMNKNHG---CAHICRETPKGGIACE--CRPGFELTK 192
C GF S C+ E C +++G C E G C C+PGF +
Sbjct: 1244 CETGFQPSPESGECVDIDE----C--EDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAP 1297
Query: 193 NQR--DCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIET----------- 239
N D N G CD+T+ RC C F + G C++
Sbjct: 1298 NGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCG 1357
Query: 240 --------------CAVN-------------NGGCDSKCHDAATGVHCTCPVG---FMLQ 269
CA + G +A TG H P + Q
Sbjct: 1358 AALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQ 1417
Query: 270 PDRKTCKDI-------DECRLNNGG-----CDHICRNTVGSFE--CSCKKGY-----KLL 310
C + EC G CD F C KGY
Sbjct: 1418 KGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWT 1477
Query: 311 INERNCQDIDECSF--DRTCDH-ICVNTPGSFQCLCHRGYLLYGITH--CGDVDECSINR 365
+ D DEC C + C+NT + CLC+ G+ Y +H C D DEC
Sbjct: 1478 FGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFH-YDASHKKCEDHDECQDL- 1535
Query: 366 GGCRFG-CINTPGSYQCTC 383
C G C+NT GS+ C C
Sbjct: 1536 -ACENGECVNTEGSFHCFC 1553
Score = 81.3 bits (199), Expect = 4e-15
Identities = 83/335 (24%), Positives = 114/335 (34%), Gaps = 67/335 (20%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKH--CKDVDECEREDNAGCVH-D 85
D DECV + C NT Y C+C G+ D H C+D DEC+ + C + +
Sbjct: 1485 DADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQ---DLACENGE 1541
Query: 86 CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEG----------------NGGCQQSCVN 129
CVN G++ C C L C++ E N C +
Sbjct: 1542 CVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRG 1601
Query: 130 MMGSY-ECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGF 188
+Y EC C++G S C R E + ++ R + RPG+
Sbjct: 1602 HRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQL------CNVARIEAEREAGVHFRPGY 1655
Query: 189 ELTKNQRDCKLTCNYGNGGCQ---------------------HTCDDTE----------- 216
E D + YG G H+ D T
Sbjct: 1656 EYGPGPDDLHYSI-YGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSEL 1714
Query: 217 QGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCK 276
Q H + +G E C + NG + +C G C C GF L C
Sbjct: 1715 QPHYVASHPEPPAGFEGLQA-EECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACV 1773
Query: 277 DIDECRLNNGG---CDH-ICRNTVGSFECSCKKGY 307
D++EC NG C H C NT GS+ C C GY
Sbjct: 1774 DVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGY 1808
Score = 54.7 bits (130), Expect = 4e-07
Identities = 120/543 (22%), Positives = 183/543 (33%), Gaps = 94/543 (17%)
Query: 340 QCLCHRGYLLYGITHCGDVDECSINRGGCRFG-CINTPGSYQCTCPAGQGRLHWNGKDCT 398
Q C +GY +THC D++EC + G C+ C+NT GSY CTC G
Sbjct: 605 QLECPQGYKRLNLTHCQDINEC-LTLGLCKDAECVNTRGSYLCTCRPGL---------ML 654
Query: 399 EP--LKCQGSPGASKAMLSCNRSGKKDTCAL----------TCPSRARFLPESENGFTVS 446
+P +C S C RS TC L C SR SE
Sbjct: 655 DPSRSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSE---CEK 711
Query: 447 CGTPSPRA----APARAGHNGNSTN---SNHCHEAAVLSIK-----QRASFKIKDAKCRL 494
C P A PA G+ S++ S E L+ QR+S + R
Sbjct: 712 CPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPGPAERQ 771
Query: 495 HLRNKGKT-EEAGRITGPGGAPCSECQVTFIHLKCDSSRKGKGRRARTPPGKEVTRLTLE 553
LR T EAG I G + + + H + A TPP E +
Sbjct: 772 PLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVT-----GNATTPPMPE------Q 820
Query: 554 LEAEVRAEETTASCG--LPCLRQRMERRLKGSLKMLRKS--INQDRFLLRLAGLDYELAH 609
AE++ E+ T S + ++R G+ + +N + Y+L
Sbjct: 821 GIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHP 880
Query: 610 KPGLVAGERAEPMESCR-PGQ--HRAGTKCVSCPQG--TYYHGQTEQCVP---------C 655
+ + C+ G+ +R G+ C G G T++C C
Sbjct: 881 SQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVC 940
Query: 656 PAGTFQEREGQLSCDLCPGSDAHGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPRGTYQ 715
G EG C+ G + G C ++ + CP G
Sbjct: 941 SGGQCTNTEGSYHCECDQG----------YIMVRKGHC----QDINECRHPGTCPDGRCV 986
Query: 716 PEAGRTLCFPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAM-GSYQPDF 774
G C C G + + +C T C+ G T++ RC+ Y+
Sbjct: 987 NSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKC--TNLEGSFRCSCEQGYEVTS 1044
Query: 775 RQNFC---------SRCPGNTSTDFDGSTSVAQCKNRQCGGELGEFTGYIESPNYPGNYP 825
+ C + CP + +GS + + C+N E G ++ +PG P
Sbjct: 1045 DEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCP 1104
Query: 826 AGV 828
+GV
Sbjct: 1105 SGV 1107
Score = 39.7 bits (91), Expect = 0.014
Identities = 22/62 (35%), Positives = 32/62 (51%), Gaps = 3/62 (4%)
Query: 92 NYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFLSDNQHT 150
N + C G+ + H C D++EC G C+ + CVN GSY C CR G L ++
Sbjct: 603 NGQLECPQGYKRLNLTH-CQDINECLT-LGLCKDAECVNTRGSYLCTCRPGLMLDPSRSR 660
Query: 151 CI 152
C+
Sbjct: 661 CV 662
Score = 37.4 bits (85), Expect = 0.070
Identities = 24/73 (32%), Positives = 32/73 (43%), Gaps = 6/73 (8%)
Query: 57 CKSGYTG-DGKHCKDVDECEREDNAGCVHD--CVNIPGNYRCTCYDGFHLAHDGHNCLDV 113
C GY + HC+D++EC G D CVN G+Y CTC G L C+
Sbjct: 608 CPQGYKRLNLTHCQDINECL---TLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSD 664
Query: 114 DECAEGNGGCQQS 126
+ G C +S
Sbjct: 665 KAISMLQGLCYRS 677
Score = 37.4 bits (85), Expect = 0.070
Identities = 97/481 (20%), Positives = 141/481 (29%), Gaps = 104/481 (21%)
Query: 372 CINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPS 431
C+N P Y+C C G +LH + CT+ +C P C G+ C +
Sbjct: 861 CVNLPDGYRCVCSPGY-QLHPSQAYCTDDNECLRDP--------CKGKGR-------CIN 904
Query: 432 RARFLPESENGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEAAVLSIKQ----RASFKI 487
R ++ C P A +G + N C + V S Q S+
Sbjct: 905 RV-------GSYSCFC---YPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHC 954
Query: 488 KDAKCRLHLRNKGKTEEAGRITGPGGAPCSEC---QVTFIHLKCDSSRKGKGRRARTPPG 544
+ + + +R KG ++ PG P C ++ L C+ +G+
Sbjct: 955 ECDQGYIMVR-KGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSC----- 1008
Query: 545 KEVTRLTLELEAEVRAEETTASCGLPCLRQRMERRLKGSLKMLRKSINQDRFLLRLAGLD 604
+V T C L+GS R S Q
Sbjct: 1009 -----------VDVNECLTPGVCA-----HGKCTNLEGSF---RCSCEQG---------- 1039
Query: 605 YEL-AHKPGLVAGERAEPMESCRPG---QHRAGTKCVSCPQGTYYHGQTEQCVP------ 654
YE+ + + G + SC G C +C G + + C
Sbjct: 1040 YEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAF 1099
Query: 655 ---CPAGTFQEREGQLSCDLCPGSDAHGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPR 711
CP+G G SC C G PLG C D P C
Sbjct: 1100 PGVCPSGVCTNTAGSFSCKDCDGGYRPSPLG--------DSCEDVDECED---PQSSCLG 1148
Query: 712 GTYQPEAGRTLCFPCGGGLTTKHEGAISFQDCDTKVQCSP-GHYYNTSIHRCIRCAMGSY 770
G + G C G +C + C+P G N+ CA G
Sbjct: 1149 GECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPG-- 1206
Query: 771 QPDFRQNFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEFTGYIESPNYPGNYPAGVEC 830
F S G + D D + C C G F E+ P P EC
Sbjct: 1207 -------FVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPS--PESGEC 1257
Query: 831 I 831
+
Sbjct: 1258 V 1258
Score = 30.8 bits (68), Expect = 6.6
Identities = 20/100 (20%), Positives = 40/100 (40%), Gaps = 5/100 (5%)
Query: 248 DSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGY 307
D++C + CTC G ML P R C + G +C ++G C+
Sbjct: 634 DAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQG----LCYRSLGPGTCTLPLAQ 689
Query: 308 KLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGY 347
++ C + + ++ C+ + +F+ +C G+
Sbjct: 690 RITKQICCCSRVGK-AWGSECEKCPLPGTEAFREICPAGH 728
Score = 30.4 bits (67), Expect = 8.6
Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 2/46 (4%)
Query: 28 QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDE 73
QD++EC+ T DA C NT SY C C+ G D + V +
Sbjct: 621 QDINECL--TLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSD 664
>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
Length = 1184
Score = 193 bits (490), Expect = 8e-49
Identities = 138/472 (29%), Positives = 196/472 (41%), Gaps = 78/472 (16%)
Query: 24 SKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVD-----ECER 76
S D DEC+ +C NT SY C C G++ DG+ C+ E +
Sbjct: 599 SLPGDDQDECLLLPGEL-CQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQ 657
Query: 77 E--------------------------DNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNC 110
E DN C C + G+ C+C+ G+ + DG +C
Sbjct: 658 EPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSC 717
Query: 111 LDVDECAEGNGGCQQS--CVNMMGSYECH----CREGFFLSDNQHTCIQRPEEGMNCMNK 164
D++EC C + CVN +GS+ C+ C G+ L D + C E+ C
Sbjct: 718 EDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE--C----EDVDECAMG 771
Query: 165 NHGC--AHICRETPKGGIACE----CRPGF------------ELTKNQRDCKLTCNYGNG 206
H C +C+ T KG C+ C GF E T C+ + N
Sbjct: 772 THTCQPGFLCQNT-KGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINT 830
Query: 207 GCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNG----GCDSKCHDAATGVHCTC 262
+TC ++ P C + DG C++ G G CH+ C C
Sbjct: 831 VGSYTC---QRNPLI-CARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDC 886
Query: 263 PVGFMLQPDRKTCKDIDECRLNNGG-CDHICRNTVGSFECSCKKGYKLLINERNCQDIDE 321
GF + C D++EC + G C H C NT+GS+ CSC G+ L + + C+D++E
Sbjct: 887 KAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNE 946
Query: 322 CSFDRTCDHICVNTPGSFQCLCHRGYLLYGITH-CGDVDECSINRGG-CRFGCINTPGSY 379
C R C C N GS+QC C +GY L H C D+DEC+ G C F C+N PGSY
Sbjct: 947 CEAQR-CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSY 1005
Query: 380 QCTCPAGQGRLHWNGKDCTEPLKCQ-GSPGASKAMLSCNRSGKKDTCALTCP 430
QC CP + NG+ C + +C G+ S+A N G CP
Sbjct: 1006 QCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECP 1057
Score = 185 bits (469), Expect = 2e-46
Identities = 120/361 (33%), Positives = 167/361 (46%), Gaps = 39/361 (10%)
Query: 26 AAQDVDECVEGTDNCHIDAICQNTPRSYKCI----CKSGYTGDGKHCKDVDECEREDNAG 81
+ +D++ECV C C NT S+ C C+ GY C+DVDEC +
Sbjct: 716 SCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHT- 774
Query: 82 CVHD--CVNIPGNYRCT----CYDGFHLAHDGHNCLDVDECAEGNGGCQQ--SCVNMMGS 133
C C N G++ C C DGF +G NC+D++EC + C+ SC+N +GS
Sbjct: 775 CQPGFLCQNTKGSFYCQARQRCMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVGS 833
Query: 134 YECH-----CREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAH--ICRETPKGGIACECRP 186
Y C C G+ SD+ C+ E C H C +C P G C+C+
Sbjct: 834 YTCQRNPLICARGYHASDDGTKCVDVNE----CETGVHRCGEGQVCHNLP-GSYRCDCKA 888
Query: 187 GFELTKNQRDCKLTCN--YGNGG--CQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAV 242
GF+ R C + N + + G CQHTC++T RC C F+L DGK C +
Sbjct: 889 GFQRDAFGRGC-IDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNEC 947
Query: 243 NNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNG-GCDHICRNTVGSFEC 301
C +C + C C G+ L D TC DIDEC G C C N GS++C
Sbjct: 948 EAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQC 1007
Query: 302 SC-KKGYKLLINERNCQDIDECSF-DRTCD--HICVNTPGSFQCL---CHRGYLLYGITH 354
+C ++GY + N R+C+D+DEC+ C C N GSF+CL C Y+ T
Sbjct: 1008 ACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTK 1067
Query: 355 C 355
C
Sbjct: 1068 C 1068
Score = 111 bits (278), Expect = 3e-24
Identities = 128/476 (26%), Positives = 180/476 (37%), Gaps = 67/476 (14%)
Query: 15 LVHARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCI-------CKSGYTGDGKH 67
L+ A + A D DEC+E ++ D +C+ R + C+ C +G G
Sbjct: 441 LIETCCAAGQQWAIDNDECLEIPESGTEDNVCRTAQR-HCCVSYLQEKSCMAGVLG---- 495
Query: 68 CKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSC 127
K+ + C EDN C +++ C G + +G +C E N C
Sbjct: 496 AKEGETCGAEDNDSCG---ISLYKQCCDCCGLGLRVRAEGQSC-------ESNPNLGYPC 545
Query: 128 VNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPG 187
++M S C E + + ++RP E + RE G E P
Sbjct: 546 NHVMLSC-CEGEEPLIVPE-----VRRPPEPAAAPRRVSEAEMAGREALSLGTEAEL-PN 598
Query: 188 FELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCI------ETCA 241
+Q +C L CQH C +T C C F L DG+TC + A
Sbjct: 599 SLPGDDQDECLLL---PGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEA 655
Query: 242 VNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFEC 301
S+ A+ T P+ P TCKD NG C +C GS C
Sbjct: 656 PQEPALKSEFSQVASN---TIPLPL---PQPNTCKD-------NGPCKQVCSTVGGSAIC 702
Query: 302 SCKKGYKLLINERNCQDIDECSFD-RTCD--HICVNTPGSFQC----LCHRGYLLYGITH 354
SC GY ++ + +C+DI+EC D TC CVNT GSF C C GY L
Sbjct: 703 SCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKD-GE 761
Query: 355 CGDVDECSINRGGCR--FGCINTPGSYQCTC--PAGQGRLHWNGKDCTEPLKCQGSPGAS 410
C DVDEC++ C+ F C NT GS+ C G L +C + +C
Sbjct: 762 CEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPC 821
Query: 411 KAMLSCNRSGKKDTCALTCPSRARFLPESENGFTV----SCGTPSPRAAPARAGHN 462
+ SC + TC AR S++G C T R + HN
Sbjct: 822 RPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHN 877
Score = 37.4 bits (85), Expect = 0.070
Identities = 20/60 (33%), Positives = 27/60 (45%), Gaps = 9/60 (15%)
Query: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCI---CKSGYTGDGK------HCKDVDECE 75
++ +DVDEC GT NC C N S++C+ C Y K C D EC+
Sbjct: 1021 RSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQ 1080
Score = 30.8 bits (68), Expect = 6.6
Identities = 50/177 (28%), Positives = 64/177 (36%), Gaps = 45/177 (25%)
Query: 625 CRPGQHRA--GTKCVS---CPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPG--SDA 677
C G H + GTKCV C G + G+ + C P G CD G DA
Sbjct: 843 CARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLP--------GSYRCDCKAGFQRDA 894
Query: 678 HGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGA 737
G G +V C PG + CQ T + G C C G +G
Sbjct: 895 FGR-GCIDVNECWAS--PG-------RLCQH----TCENTLGSYRC-SCASGFLLAADG- 938
Query: 738 ISFQDCDTKVQCSPGHYYNTSIHRCIR-CA--MGSYQPDFRQNFCSRCPGNTSTDFD 791
+ C+ +C RC + CA GSYQ RQ + G+T TD D
Sbjct: 939 ---KRCEDVNECEA--------QRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDID 984
>gi|110347437 latent transforming growth factor beta binding protein
4 isoform c [Homo sapiens]
Length = 1557
Score = 189 bits (481), Expect = 8e-48
Identities = 138/438 (31%), Positives = 187/438 (42%), Gaps = 62/438 (14%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGK--HCKDVDECEREDNAGCVHDC 86
DVDEC C C+N+P S++C+C G+ + C DVDEC R + C
Sbjct: 520 DVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRC 578
Query: 87 VNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGC-QQSCVNMMGSYECHCREGFFLS 145
N PG++ C C G+ A G +C DVDEC + G C + +C N+ GS+ C C GF
Sbjct: 579 ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF--- 635
Query: 146 DNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCK------- 198
C + +E C + C + G C C GF C+
Sbjct: 636 -RGSACEEDVDE---CAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECAR 691
Query: 199 --LTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDA 254
C YG C++TE +C C + F +T G C ++ C + +C ++
Sbjct: 692 SPPPCTYGR------CENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNS 745
Query: 255 ATGVHC-TCPVGFMLQPDRKTCKDIDECRLNNGGC--DHICRNTVGSFECSCKKGYKLLI 311
C TCP G L R C D+DEC C C NT GSF CSC GY+
Sbjct: 746 PGSFQCRTCPSGHHLH--RGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPS 803
Query: 312 NERN-CQDIDECSFDRTC--DHICVNTPGSFQCLCHRGYLLYGI-THCGDVDECSINRGG 367
C D++EC C C+NT GSF C C GY C DVDECS
Sbjct: 804 GRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS-EEDL 862
Query: 368 CRFG-CINTPGSYQCTCPAGQGRLHWNGKDCTEPL----------------KCQGSPGAS 410
C+ G C NT GS++C CP G H G D L +C+ SPG+
Sbjct: 863 CQSGICTNTDGSFECICPPG----HRAGPDLASCLDVDECRERGPALCGSQRCENSPGSY 918
Query: 411 KAMLSCN---RSGKKDTC 425
+ + C+ +G + TC
Sbjct: 919 RCVRDCDPGYHAGPEGTC 936
Score = 178 bits (452), Expect = 2e-44
Identities = 150/510 (29%), Positives = 200/510 (39%), Gaps = 81/510 (15%)
Query: 7 PGLCLLVLLVHARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGK 66
PG L V +AA + + QDVDEC + C A C+N P S++C+C +G+ G
Sbjct: 582 PGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSAC 640
Query: 67 HCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS 126
+DVDEC +E C N G++ C C GF G C DVDECA C
Sbjct: 641 E-EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYG 699
Query: 127 -CVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACE-C 184
C N GS++C C GF +T E+ C N C +P G C C
Sbjct: 700 RCENTEGSFQCVCPMGF----QPNTAGSECEDVDECENHLACPGQECVNSP-GSFQCRTC 754
Query: 185 RPGFELTKNQRDCKLTCNYGNGGC--QHTCDDTEQGPRCGCHIKFVLHT-------DGKT 235
G L + + C+ G C C +TE RC C + + D
Sbjct: 755 PSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNE 814
Query: 236 CIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNT 295
C+E G +C + CTC G+ P +C D+DEC + IC NT
Sbjct: 815 CLEGDFCFPHG---ECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNT 871
Query: 296 VGSFECSCKKGYKLLINERNCQDIDEC--------------------------------S 323
GSFEC C G++ + +C D+DEC
Sbjct: 872 DGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAG 931
Query: 324 FDRTCDHI---------------CVNTPGSFQC--LCHRGYLLYGITHCGDVDECSINRG 366
+ TCD + C NTPGS++C C GY C DVDEC NR
Sbjct: 932 PEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECR-NRS 990
Query: 367 --GCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDT 424
G C N PGS+QC C G +G+ C + +C+ G A L N G +
Sbjct: 991 FCGAHAVCQNLPGSFQCLCDQGYEGAR-DGRHCVDVNECETLQGVCGAALCENVEG---S 1046
Query: 425 CALTCPSRARFLPESENGFTVSCGTPSPRA 454
CP+ PE + T C P A
Sbjct: 1047 FLCVCPNS----PEEFDPMTGRCVPPRTSA 1072
Score = 174 bits (440), Expect = 5e-43
Identities = 113/368 (30%), Positives = 150/368 (40%), Gaps = 56/368 (15%)
Query: 46 CQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHL 103
C + P Y C C SG+ + G C DVDEC R C N PG++RC C GF
Sbjct: 494 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRA 553
Query: 104 AHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCM 162
CLDVDEC C C N GS+ C C G+ + + +C ++ C
Sbjct: 554 GPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASC----QDVDECT 609
Query: 163 NKNHGCAH-ICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDD-TEQGPR 220
C C+ P G C C GF C+ D+ ++ P
Sbjct: 610 QSPGLCGRGACKNLP-GSFRCVCPAGFR---------------GSACEEDVDECAQEPPP 653
Query: 221 CGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDE 280
CG +C + A HC CP GF + C+D+DE
Sbjct: 654 CG-------------------------PGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDE 688
Query: 281 CRLNNGGCDH-ICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTC-DHICVNTPGS 338
C + C + C NT GSF+C C G++ C+D+DEC C CVN+PGS
Sbjct: 689 CARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGS 748
Query: 339 FQC-LCHRGYLLYGITHCGDVDECSINRGGC--RFGCINTPGSYQCTCPAGQGRLHWNGK 395
FQC C G+ L+ C DVDECS C C NT GS++C+C G
Sbjct: 749 FQCRTCPSGHHLHR-GRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPG 807
Query: 396 DCTEPLKC 403
C + +C
Sbjct: 808 PCADVNEC 815
Score = 114 bits (286), Expect = 3e-25
Identities = 104/346 (30%), Positives = 141/346 (40%), Gaps = 42/346 (12%)
Query: 29 DVDECVE-GTDNCHIDAICQNTPRSYKCI--CKSGYTGD-GKHCKDVDECEREDNAGCVH 84
DVDEC E G + C C+NTP SY+C C GY G C+DVDEC G
Sbjct: 938 DVDECQEYGPEICGAQR-CENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHA 996
Query: 85 DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFF 143
C N+PG+++C C G+ A DG +C+DV+EC G C + C N+ GS+ C
Sbjct: 997 VCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLC------- 1049
Query: 144 LSDNQHTCIQRPEE----GMNCMNKNHGCAHICRETPKGGIA--CECRPGFELTKNQRDC 197
C PEE C+ P+ + RP +
Sbjct: 1050 ------VCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPST 1103
Query: 198 KLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNG---GCD-SKCHD 253
G+G + C P C + + C C V G GC +C
Sbjct: 1104 PRQGPVGSG--RRECYFDTAAPDA-CDNILARNVTWQECC--CTVGEGWGSGCRIQQCPG 1158
Query: 254 AATGVHCT-CPVGF-MLQP--DRKTCKDIDECRL-NNGGCDH-ICRNTVGSFECSCKKGY 307
T + + CP G L P D +D+DEC+L + C +C NT + C C GY
Sbjct: 1159 TETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGY 1218
Query: 308 KLLINERNCQDIDECSFDR-TCD-HICVNTPGSFQCLCHRGYLLYG 351
C D DEC+ + C+ CVNT GS+ C C +L G
Sbjct: 1219 YYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDG 1264
Score = 70.1 bits (170), Expect = 1e-11
Identities = 47/172 (27%), Positives = 70/172 (40%), Gaps = 16/172 (9%)
Query: 40 CHIDAICQNTPRSYKCICKSGY-----TGDGKHCKDVDECEREDNAGCVHD-CVNIPGNY 93
C I Y+ +C G +GD +DVDEC+ + C CVN Y
Sbjct: 1151 CRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGY 1210
Query: 94 RCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFLSDNQHTCI 152
C C +G++ C+D DECA+ C+ CVN +GSY C C L +Q C+
Sbjct: 1211 SCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCV 1270
Query: 153 QRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYG 204
+ ++ N G +C + + C P + +C C YG
Sbjct: 1271 SNESQS---LDDNLG---VCWQEVGADLVCS-HPRLDRQATYTEC--CCLYG 1313
Score = 58.9 bits (141), Expect = 2e-08
Identities = 29/87 (33%), Positives = 42/87 (48%), Gaps = 7/87 (8%)
Query: 70 DVDECEREDNAGCVHD-CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGG----CQ 124
+ +EC D GC + CV +P + C C+DG+ L C+D++EC E
Sbjct: 1466 EAEECGILD--GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1523
Query: 125 QSCVNMMGSYECHCREGFFLSDNQHTC 151
C+N GS+ C CR GF + H C
Sbjct: 1524 ARCLNTDGSFRCICRPGFAPTHQPHHC 1550
Score = 55.1 bits (131), Expect = 3e-07
Identities = 29/72 (40%), Positives = 35/72 (48%), Gaps = 2/72 (2%)
Query: 28 QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGK--HCKDVDECEREDNAGCVHD 85
+DVDEC D +C NT Y C C +GY + C D DEC E+ A
Sbjct: 1185 RDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGR 1244
Query: 86 CVNIPGNYRCTC 97
CVN G+Y CTC
Sbjct: 1245 CVNTVGSYHCTC 1256
Score = 52.4 bits (124), Expect = 2e-06
Identities = 25/76 (32%), Positives = 37/76 (48%), Gaps = 5/76 (6%)
Query: 277 DIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICV--- 333
+ +EC + +G + C F C C GY+L + C DI+EC +CV
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1525
Query: 334 --NTPGSFQCLCHRGY 347
NT GSF+C+C G+
Sbjct: 1526 CLNTDGSFRCICRPGF 1541
Score = 52.0 bits (123), Expect = 3e-06
Identities = 49/174 (28%), Positives = 65/174 (37%), Gaps = 24/174 (13%)
Query: 251 CHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKL 309
C + A G C C G+ R C D DEC C+ C NTVGS+ C+C+ L
Sbjct: 1203 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1262
Query: 310 LINERNC-----QDID--------ECSFDRTCDHICVNTPGSF-QCLCHRGYLLYGITHC 355
++R C Q +D E D C H ++ ++ +C C LYG
Sbjct: 1263 DGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCC-----LYGEAWG 1317
Query: 356 GDVDECSINRGGCRFGCINT--PGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSP 407
D C N P +Y P G G + G D P QG P
Sbjct: 1318 MDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDLGPPY--QGLP 1369
Score = 51.6 bits (122), Expect = 4e-06
Identities = 25/70 (35%), Positives = 35/70 (50%), Gaps = 5/70 (7%)
Query: 46 CQNTPRSYKCICKSGYTGDGKH--CKDVDECEREDNAG--CVH-DCVNIPGNYRCTCYDG 100
C P + C C GY D C D++EC+ + A CV+ C+N G++RC C G
Sbjct: 1481 CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPG 1540
Query: 101 FHLAHDGHNC 110
F H H+C
Sbjct: 1541 FAPTHQPHHC 1550
Score = 50.8 bits (120), Expect = 6e-06
Identities = 39/122 (31%), Positives = 53/122 (43%), Gaps = 12/122 (9%)
Query: 97 CYDGFHLAHDGHNCLDVDECAEGNGGCQQ-SCVNMMGSYECHCREGFFLSDNQHTCIQR- 154
C GF + +C DVDECA G G CQ C N G Y C C +GF L ++ +CI +
Sbjct: 277 CPTGFERVNG--SCEDVDECATG-GRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 333
Query: 155 --PEEGMNCMN--KNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQH 210
E C ++ GC+ I C R G R C+L +G+ G +
Sbjct: 334 VISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVG---KAWGRGCQLCPPFGSEGFRE 390
Query: 211 TC 212
C
Sbjct: 391 IC 392
Score = 48.5 bits (114), Expect = 3e-05
Identities = 24/68 (35%), Positives = 31/68 (45%), Gaps = 3/68 (4%)
Query: 57 CKSGYTGDGKHCKDVDECEREDNAGCVH-DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDE 115
C +G+ C+DVDEC C H +C N G Y C C DGF L +C+
Sbjct: 277 CPTGFERVNGSCEDVDECAT--GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHV 334
Query: 116 CAEGNGGC 123
+E G C
Sbjct: 335 ISEAKGPC 342
Score = 47.8 bits (112), Expect = 5e-05
Identities = 29/118 (24%), Positives = 47/118 (39%), Gaps = 4/118 (3%)
Query: 203 YGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTC 262
Y + + + + E+ P G + + + E C + +G + +C G C C
Sbjct: 1433 YRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEECGILDGCTNGRCVRVPEGFTCRC 1492
Query: 263 PVGFMLQPDRKTCKDIDECRLNNGG----CDHICRNTVGSFECSCKKGYKLLINERNC 316
G+ L R C DI+EC + C NT GSF C C+ G+ +C
Sbjct: 1493 FDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1550
Score = 45.1 bits (105), Expect = 3e-04
Identities = 33/101 (32%), Positives = 44/101 (43%), Gaps = 13/101 (12%)
Query: 297 GSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITH-- 354
GS+ S + Y+ L E C +D C+ R CV P F C C GY L +T
Sbjct: 1452 GSYAGSLAEPYEELEAEE-CGILDGCTNGR-----CVRVPEGFTCRCFDGYRL-DMTRMA 1504
Query: 355 CGDVDECSINRGGCRF----GCINTPGSYQCTCPAGQGRLH 391
C D++EC C+NT GS++C C G H
Sbjct: 1505 CVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTH 1545
Score = 42.0 bits (97), Expect = 0.003
Identities = 18/48 (37%), Positives = 28/48 (58%), Gaps = 3/48 (6%)
Query: 303 CKKGYKLLINERNCQDIDECSFDRTCDH-ICVNTPGSFQCLCHRGYLL 349
C G++ + +C+D+DEC+ C H C NT G + C+C G+LL
Sbjct: 277 CPTGFERV--NGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLL 322
Score = 41.6 bits (96), Expect = 0.004
Identities = 21/56 (37%), Positives = 29/56 (51%), Gaps = 4/56 (7%)
Query: 262 CPVGFMLQPDRKTCKDIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKLLINERNC 316
CP GF + +C+D+DEC G C H C NT G + C C G+ L + +C
Sbjct: 277 CPTGF--ERVNGSCEDVDECA-TGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC 329
Score = 40.8 bits (94), Expect = 0.006
Identities = 31/134 (23%), Positives = 49/134 (36%), Gaps = 16/134 (11%)
Query: 212 CDDTEQGPRCGCHIKFVLHTDGKTCIET--CAVNNGGCDS-KCHDAATGVHCTCPVGFML 268
C +T G C C + HT CI+ CA C+ +C + HCTC +L
Sbjct: 1203 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1262
Query: 269 QPDRKTCKDIDECRLNNG--------GCDHICRN-----TVGSFECSCKKGYKLLINERN 315
++ C + L++ G D +C + EC C G ++
Sbjct: 1263 DGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCAL 1322
Query: 316 CQDIDECSFDRTCD 329
C D F+ C+
Sbjct: 1323 CPAQDSDDFEALCN 1336
Score = 39.3 bits (90), Expect = 0.019
Identities = 18/33 (54%), Positives = 20/33 (60%), Gaps = 2/33 (6%)
Query: 355 CGDVDECSINRGGCRFG-CINTPGSYQCTCPAG 386
C DVDEC+ G C+ G C NT G Y C CP G
Sbjct: 288 CEDVDECATG-GRCQHGECANTRGGYTCVCPDG 319
Score = 39.3 bits (90), Expect = 0.019
Identities = 24/91 (26%), Positives = 36/91 (39%), Gaps = 9/91 (9%)
Query: 111 LDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPE----EGMNCMNKNH 166
L+ +EC +G CV + + C C +G+ L + C+ E E + + N
Sbjct: 1465 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524
Query: 167 GCAHICRETPKGGIACECRPGFELTKNQRDC 197
C + G C CRPGF T C
Sbjct: 1525 RCLN-----TDGSFRCICRPGFAPTHQPHHC 1550
Score = 36.6 bits (83), Expect = 0.12
Identities = 35/133 (26%), Positives = 47/133 (35%), Gaps = 16/133 (12%)
Query: 184 CRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVN 243
C G L DC+L C+ G + GP C F ++ CA
Sbjct: 244 CCRGAGLAWGVHDCQL-CSERLGNSERV--SAPDGP---CPTGFERVNGSCEDVDECATG 297
Query: 244 NGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKD---IDECR------LNNGGCD-HICR 293
+C + G C CP GF+L R +C I E + L +GGC I R
Sbjct: 298 GRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILR 357
Query: 294 NTVGSFECSCKKG 306
N C + G
Sbjct: 358 NITKQICCCSRVG 370
Score = 34.3 bits (77), Expect = 0.60
Identities = 17/47 (36%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 26 AAQDVDEC--VEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHC 68
A D++EC E ++A C NT S++CIC+ G+ T HC
Sbjct: 1504 ACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1550
Score = 33.9 bits (76), Expect = 0.78
Identities = 53/215 (24%), Positives = 68/215 (31%), Gaps = 40/215 (18%)
Query: 625 CRPGQHRAGTKCVSCPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGSDAHGPLGAT 684
C PG RAG + C H PC G + G C +CP P GA+
Sbjct: 547 CGPG-FRAGPRAAECLDVDECHRVPP---PCDLGRCENTPGSFLC-VCPAGYQAAPHGAS 601
Query: 685 --NVTTCAGQ-------------------CPPG------QHSVDGF-KPCQPCPRGTYQP 716
+V C CP G + VD + PC G
Sbjct: 602 CQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDN 661
Query: 717 EAGRTLCFPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAMGSYQPDFRQ 776
AG C C G ++ GA QD D + P Y RC GS+Q
Sbjct: 662 TAGSFHC-ACPAGFRSRGPGA-PCQDVDECARSPPPCTYG----RCENTE-GSFQCVCPM 714
Query: 777 NFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEF 811
F G+ D D + C ++C G F
Sbjct: 715 GFQPNTAGSECEDVDECENHLACPGQECVNSPGSF 749
Score = 32.7 bits (73), Expect = 1.7
Identities = 15/48 (31%), Positives = 22/48 (45%), Gaps = 2/48 (4%)
Query: 26 AAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDE 73
+ +DVDEC G H + C NT Y C+C G+ D + +
Sbjct: 287 SCEDVDECATGGRCQHGE--CANTRGGYTCVCPDGFLLDSSRSSCISQ 332
>gi|110347412 latent transforming growth factor beta binding protein
4 isoform b [Homo sapiens]
Length = 1587
Score = 189 bits (481), Expect = 8e-48
Identities = 138/438 (31%), Positives = 187/438 (42%), Gaps = 62/438 (14%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGK--HCKDVDECEREDNAGCVHDC 86
DVDEC C C+N+P S++C+C G+ + C DVDEC R + C
Sbjct: 550 DVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRC 608
Query: 87 VNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGC-QQSCVNMMGSYECHCREGFFLS 145
N PG++ C C G+ A G +C DVDEC + G C + +C N+ GS+ C C GF
Sbjct: 609 ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF--- 665
Query: 146 DNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCK------- 198
C + +E C + C + G C C GF C+
Sbjct: 666 -RGSACEEDVDE---CAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECAR 721
Query: 199 --LTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDA 254
C YG C++TE +C C + F +T G C ++ C + +C ++
Sbjct: 722 SPPPCTYGR------CENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNS 775
Query: 255 ATGVHC-TCPVGFMLQPDRKTCKDIDECRLNNGGC--DHICRNTVGSFECSCKKGYKLLI 311
C TCP G L R C D+DEC C C NT GSF CSC GY+
Sbjct: 776 PGSFQCRTCPSGHHLH--RGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPS 833
Query: 312 NERN-CQDIDECSFDRTC--DHICVNTPGSFQCLCHRGYLLYGI-THCGDVDECSINRGG 367
C D++EC C C+NT GSF C C GY C DVDECS
Sbjct: 834 GRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS-EEDL 892
Query: 368 CRFG-CINTPGSYQCTCPAGQGRLHWNGKDCTEPL----------------KCQGSPGAS 410
C+ G C NT GS++C CP G H G D L +C+ SPG+
Sbjct: 893 CQSGICTNTDGSFECICPPG----HRAGPDLASCLDVDECRERGPALCGSQRCENSPGSY 948
Query: 411 KAMLSCN---RSGKKDTC 425
+ + C+ +G + TC
Sbjct: 949 RCVRDCDPGYHAGPEGTC 966
Score = 178 bits (452), Expect = 2e-44
Identities = 150/510 (29%), Positives = 200/510 (39%), Gaps = 81/510 (15%)
Query: 7 PGLCLLVLLVHARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGK 66
PG L V +AA + + QDVDEC + C A C+N P S++C+C +G+ G
Sbjct: 612 PGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSAC 670
Query: 67 HCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS 126
+DVDEC +E C N G++ C C GF G C DVDECA C
Sbjct: 671 E-EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYG 729
Query: 127 -CVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACE-C 184
C N GS++C C GF +T E+ C N C +P G C C
Sbjct: 730 RCENTEGSFQCVCPMGF----QPNTAGSECEDVDECENHLACPGQECVNSP-GSFQCRTC 784
Query: 185 RPGFELTKNQRDCKLTCNYGNGGC--QHTCDDTEQGPRCGCHIKFVLHT-------DGKT 235
G L + + C+ G C C +TE RC C + + D
Sbjct: 785 PSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNE 844
Query: 236 CIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNT 295
C+E G +C + CTC G+ P +C D+DEC + IC NT
Sbjct: 845 CLEGDFCFPHG---ECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNT 901
Query: 296 VGSFECSCKKGYKLLINERNCQDIDEC--------------------------------S 323
GSFEC C G++ + +C D+DEC
Sbjct: 902 DGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAG 961
Query: 324 FDRTCDHI---------------CVNTPGSFQC--LCHRGYLLYGITHCGDVDECSINRG 366
+ TCD + C NTPGS++C C GY C DVDEC NR
Sbjct: 962 PEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECR-NRS 1020
Query: 367 --GCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDT 424
G C N PGS+QC C G +G+ C + +C+ G A L N G +
Sbjct: 1021 FCGAHAVCQNLPGSFQCLCDQGYEGAR-DGRHCVDVNECETLQGVCGAALCENVEG---S 1076
Query: 425 CALTCPSRARFLPESENGFTVSCGTPSPRA 454
CP+ PE + T C P A
Sbjct: 1077 FLCVCPNS----PEEFDPMTGRCVPPRTSA 1102
Score = 174 bits (440), Expect = 5e-43
Identities = 113/368 (30%), Positives = 150/368 (40%), Gaps = 56/368 (15%)
Query: 46 CQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHL 103
C + P Y C C SG+ + G C DVDEC R C N PG++RC C GF
Sbjct: 524 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRA 583
Query: 104 AHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCM 162
CLDVDEC C C N GS+ C C G+ + + +C ++ C
Sbjct: 584 GPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASC----QDVDECT 639
Query: 163 NKNHGCAH-ICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDD-TEQGPR 220
C C+ P G C C GF C+ D+ ++ P
Sbjct: 640 QSPGLCGRGACKNLP-GSFRCVCPAGFR---------------GSACEEDVDECAQEPPP 683
Query: 221 CGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDE 280
CG +C + A HC CP GF + C+D+DE
Sbjct: 684 CG-------------------------PGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDE 718
Query: 281 CRLNNGGCDH-ICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTC-DHICVNTPGS 338
C + C + C NT GSF+C C G++ C+D+DEC C CVN+PGS
Sbjct: 719 CARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGS 778
Query: 339 FQC-LCHRGYLLYGITHCGDVDECSINRGGC--RFGCINTPGSYQCTCPAGQGRLHWNGK 395
FQC C G+ L+ C DVDECS C C NT GS++C+C G
Sbjct: 779 FQCRTCPSGHHLHR-GRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPG 837
Query: 396 DCTEPLKC 403
C + +C
Sbjct: 838 PCADVNEC 845
Score = 114 bits (286), Expect = 3e-25
Identities = 104/346 (30%), Positives = 141/346 (40%), Gaps = 42/346 (12%)
Query: 29 DVDECVE-GTDNCHIDAICQNTPRSYKCI--CKSGYTGD-GKHCKDVDECEREDNAGCVH 84
DVDEC E G + C C+NTP SY+C C GY G C+DVDEC G
Sbjct: 968 DVDECQEYGPEICGAQR-CENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHA 1026
Query: 85 DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFF 143
C N+PG+++C C G+ A DG +C+DV+EC G C + C N+ GS+ C
Sbjct: 1027 VCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLC------- 1079
Query: 144 LSDNQHTCIQRPEE----GMNCMNKNHGCAHICRETPKGGIA--CECRPGFELTKNQRDC 197
C PEE C+ P+ + RP +
Sbjct: 1080 ------VCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPST 1133
Query: 198 KLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNG---GCD-SKCHD 253
G+G + C P C + + C C V G GC +C
Sbjct: 1134 PRQGPVGSG--RRECYFDTAAPDA-CDNILARNVTWQECC--CTVGEGWGSGCRIQQCPG 1188
Query: 254 AATGVHCT-CPVGF-MLQP--DRKTCKDIDECRL-NNGGCDH-ICRNTVGSFECSCKKGY 307
T + + CP G L P D +D+DEC+L + C +C NT + C C GY
Sbjct: 1189 TETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGY 1248
Query: 308 KLLINERNCQDIDECSFDR-TCD-HICVNTPGSFQCLCHRGYLLYG 351
C D DEC+ + C+ CVNT GS+ C C +L G
Sbjct: 1249 YYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDG 1294
Score = 70.1 bits (170), Expect = 1e-11
Identities = 47/172 (27%), Positives = 70/172 (40%), Gaps = 16/172 (9%)
Query: 40 CHIDAICQNTPRSYKCICKSGY-----TGDGKHCKDVDECEREDNAGCVHD-CVNIPGNY 93
C I Y+ +C G +GD +DVDEC+ + C CVN Y
Sbjct: 1181 CRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGY 1240
Query: 94 RCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFLSDNQHTCI 152
C C +G++ C+D DECA+ C+ CVN +GSY C C L +Q C+
Sbjct: 1241 SCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCV 1300
Query: 153 QRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYG 204
+ ++ N G +C + + C P + +C C YG
Sbjct: 1301 SNESQS---LDDNLG---VCWQEVGADLVCS-HPRLDRQATYTEC--CCLYG 1343
Score = 58.9 bits (141), Expect = 2e-08
Identities = 29/87 (33%), Positives = 42/87 (48%), Gaps = 7/87 (8%)
Query: 70 DVDECEREDNAGCVHD-CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGG----CQ 124
+ +EC D GC + CV +P + C C+DG+ L C+D++EC E
Sbjct: 1496 EAEECGILD--GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1553
Query: 125 QSCVNMMGSYECHCREGFFLSDNQHTC 151
C+N GS+ C CR GF + H C
Sbjct: 1554 ARCLNTDGSFRCICRPGFAPTHQPHHC 1580
Score = 55.1 bits (131), Expect = 3e-07
Identities = 29/72 (40%), Positives = 35/72 (48%), Gaps = 2/72 (2%)
Query: 28 QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGK--HCKDVDECEREDNAGCVHD 85
+DVDEC D +C NT Y C C +GY + C D DEC E+ A
Sbjct: 1215 RDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGR 1274
Query: 86 CVNIPGNYRCTC 97
CVN G+Y CTC
Sbjct: 1275 CVNTVGSYHCTC 1286
Score = 52.4 bits (124), Expect = 2e-06
Identities = 25/76 (32%), Positives = 37/76 (48%), Gaps = 5/76 (6%)
Query: 277 DIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICV--- 333
+ +EC + +G + C F C C GY+L + C DI+EC +CV
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1555
Query: 334 --NTPGSFQCLCHRGY 347
NT GSF+C+C G+
Sbjct: 1556 CLNTDGSFRCICRPGF 1571
Score = 52.0 bits (123), Expect = 3e-06
Identities = 49/174 (28%), Positives = 65/174 (37%), Gaps = 24/174 (13%)
Query: 251 CHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKL 309
C + A G C C G+ R C D DEC C+ C NTVGS+ C+C+ L
Sbjct: 1233 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1292
Query: 310 LINERNC-----QDID--------ECSFDRTCDHICVNTPGSF-QCLCHRGYLLYGITHC 355
++R C Q +D E D C H ++ ++ +C C LYG
Sbjct: 1293 DGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCC-----LYGEAWG 1347
Query: 356 GDVDECSINRGGCRFGCINT--PGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSP 407
D C N P +Y P G G + G D P QG P
Sbjct: 1348 MDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDLGPPY--QGLP 1399
Score = 51.6 bits (122), Expect = 4e-06
Identities = 25/70 (35%), Positives = 35/70 (50%), Gaps = 5/70 (7%)
Query: 46 CQNTPRSYKCICKSGYTGDGKH--CKDVDECEREDNAG--CVH-DCVNIPGNYRCTCYDG 100
C P + C C GY D C D++EC+ + A CV+ C+N G++RC C G
Sbjct: 1511 CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPG 1570
Query: 101 FHLAHDGHNC 110
F H H+C
Sbjct: 1571 FAPTHQPHHC 1580
Score = 50.8 bits (120), Expect = 6e-06
Identities = 39/122 (31%), Positives = 53/122 (43%), Gaps = 12/122 (9%)
Query: 97 CYDGFHLAHDGHNCLDVDECAEGNGGCQQ-SCVNMMGSYECHCREGFFLSDNQHTCIQR- 154
C GF + +C DVDECA G G CQ C N G Y C C +GF L ++ +CI +
Sbjct: 307 CPTGFERVNG--SCEDVDECATG-GRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 363
Query: 155 --PEEGMNCMN--KNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQH 210
E C ++ GC+ I C R G R C+L +G+ G +
Sbjct: 364 VISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVG---KAWGRGCQLCPPFGSEGFRE 420
Query: 211 TC 212
C
Sbjct: 421 IC 422
Score = 48.5 bits (114), Expect = 3e-05
Identities = 24/68 (35%), Positives = 31/68 (45%), Gaps = 3/68 (4%)
Query: 57 CKSGYTGDGKHCKDVDECEREDNAGCVH-DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDE 115
C +G+ C+DVDEC C H +C N G Y C C DGF L +C+
Sbjct: 307 CPTGFERVNGSCEDVDECAT--GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHV 364
Query: 116 CAEGNGGC 123
+E G C
Sbjct: 365 ISEAKGPC 372
Score = 47.8 bits (112), Expect = 5e-05
Identities = 29/118 (24%), Positives = 47/118 (39%), Gaps = 4/118 (3%)
Query: 203 YGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTC 262
Y + + + + E+ P G + + + E C + +G + +C G C C
Sbjct: 1463 YRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEECGILDGCTNGRCVRVPEGFTCRC 1522
Query: 263 PVGFMLQPDRKTCKDIDECRLNNGG----CDHICRNTVGSFECSCKKGYKLLINERNC 316
G+ L R C DI+EC + C NT GSF C C+ G+ +C
Sbjct: 1523 FDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1580
Score = 45.1 bits (105), Expect = 3e-04
Identities = 33/101 (32%), Positives = 44/101 (43%), Gaps = 13/101 (12%)
Query: 297 GSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITH-- 354
GS+ S + Y+ L E C +D C+ R CV P F C C GY L +T
Sbjct: 1482 GSYAGSLAEPYEELEAEE-CGILDGCTNGR-----CVRVPEGFTCRCFDGYRL-DMTRMA 1534
Query: 355 CGDVDECSINRGGCRF----GCINTPGSYQCTCPAGQGRLH 391
C D++EC C+NT GS++C C G H
Sbjct: 1535 CVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTH 1575
Score = 42.0 bits (97), Expect = 0.003
Identities = 18/48 (37%), Positives = 28/48 (58%), Gaps = 3/48 (6%)
Query: 303 CKKGYKLLINERNCQDIDECSFDRTCDH-ICVNTPGSFQCLCHRGYLL 349
C G++ + +C+D+DEC+ C H C NT G + C+C G+LL
Sbjct: 307 CPTGFERV--NGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLL 352
Score = 41.6 bits (96), Expect = 0.004
Identities = 21/56 (37%), Positives = 29/56 (51%), Gaps = 4/56 (7%)
Query: 262 CPVGFMLQPDRKTCKDIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKLLINERNC 316
CP GF + +C+D+DEC G C H C NT G + C C G+ L + +C
Sbjct: 307 CPTGF--ERVNGSCEDVDECA-TGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC 359
Score = 40.8 bits (94), Expect = 0.006
Identities = 31/134 (23%), Positives = 49/134 (36%), Gaps = 16/134 (11%)
Query: 212 CDDTEQGPRCGCHIKFVLHTDGKTCIET--CAVNNGGCDS-KCHDAATGVHCTCPVGFML 268
C +T G C C + HT CI+ CA C+ +C + HCTC +L
Sbjct: 1233 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1292
Query: 269 QPDRKTCKDIDECRLNNG--------GCDHICRN-----TVGSFECSCKKGYKLLINERN 315
++ C + L++ G D +C + EC C G ++
Sbjct: 1293 DGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCAL 1352
Query: 316 CQDIDECSFDRTCD 329
C D F+ C+
Sbjct: 1353 CPAQDSDDFEALCN 1366
Score = 39.3 bits (90), Expect = 0.019
Identities = 18/33 (54%), Positives = 20/33 (60%), Gaps = 2/33 (6%)
Query: 355 CGDVDECSINRGGCRFG-CINTPGSYQCTCPAG 386
C DVDEC+ G C+ G C NT G Y C CP G
Sbjct: 318 CEDVDECATG-GRCQHGECANTRGGYTCVCPDG 349
Score = 39.3 bits (90), Expect = 0.019
Identities = 24/91 (26%), Positives = 36/91 (39%), Gaps = 9/91 (9%)
Query: 111 LDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPE----EGMNCMNKNH 166
L+ +EC +G CV + + C C +G+ L + C+ E E + + N
Sbjct: 1495 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554
Query: 167 GCAHICRETPKGGIACECRPGFELTKNQRDC 197
C + G C CRPGF T C
Sbjct: 1555 RCLN-----TDGSFRCICRPGFAPTHQPHHC 1580
Score = 36.6 bits (83), Expect = 0.12
Identities = 35/133 (26%), Positives = 47/133 (35%), Gaps = 16/133 (12%)
Query: 184 CRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVN 243
C G L DC+L C+ G + GP C F ++ CA
Sbjct: 274 CCRGAGLAWGVHDCQL-CSERLGNSERV--SAPDGP---CPTGFERVNGSCEDVDECATG 327
Query: 244 NGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKD---IDECR------LNNGGCD-HICR 293
+C + G C CP GF+L R +C I E + L +GGC I R
Sbjct: 328 GRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILR 387
Query: 294 NTVGSFECSCKKG 306
N C + G
Sbjct: 388 NITKQICCCSRVG 400
Score = 34.3 bits (77), Expect = 0.60
Identities = 17/47 (36%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 26 AAQDVDEC--VEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHC 68
A D++EC E ++A C NT S++CIC+ G+ T HC
Sbjct: 1534 ACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1580
Score = 33.9 bits (76), Expect = 0.78
Identities = 53/215 (24%), Positives = 68/215 (31%), Gaps = 40/215 (18%)
Query: 625 CRPGQHRAGTKCVSCPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGSDAHGPLGAT 684
C PG RAG + C H PC G + G C +CP P GA+
Sbjct: 577 CGPG-FRAGPRAAECLDVDECHRVPP---PCDLGRCENTPGSFLC-VCPAGYQAAPHGAS 631
Query: 685 --NVTTCAGQ-------------------CPPG------QHSVDGF-KPCQPCPRGTYQP 716
+V C CP G + VD + PC G
Sbjct: 632 CQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDN 691
Query: 717 EAGRTLCFPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAMGSYQPDFRQ 776
AG C C G ++ GA QD D + P Y RC GS+Q
Sbjct: 692 TAGSFHC-ACPAGFRSRGPGA-PCQDVDECARSPPPCTYG----RCENTE-GSFQCVCPM 744
Query: 777 NFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEF 811
F G+ D D + C ++C G F
Sbjct: 745 GFQPNTAGSECEDVDECENHLACPGQECVNSPGSF 779
Score = 32.7 bits (73), Expect = 1.7
Identities = 15/48 (31%), Positives = 22/48 (45%), Gaps = 2/48 (4%)
Query: 26 AAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDE 73
+ +DVDEC G H + C NT Y C+C G+ D + +
Sbjct: 317 SCEDVDECATGGRCQHGE--CANTRGGYTCVCPDGFLLDSSRSSCISQ 362
>gi|110347431 latent transforming growth factor beta binding protein 4
isoform a [Homo sapiens]
Length = 1624
Score = 189 bits (481), Expect = 8e-48
Identities = 138/438 (31%), Positives = 187/438 (42%), Gaps = 62/438 (14%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGK--HCKDVDECEREDNAGCVHDC 86
DVDEC C C+N+P S++C+C G+ + C DVDEC R + C
Sbjct: 587 DVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRC 645
Query: 87 VNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGC-QQSCVNMMGSYECHCREGFFLS 145
N PG++ C C G+ A G +C DVDEC + G C + +C N+ GS+ C C GF
Sbjct: 646 ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGF--- 702
Query: 146 DNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCK------- 198
C + +E C + C + G C C GF C+
Sbjct: 703 -RGSACEEDVDE---CAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECAR 758
Query: 199 --LTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDA 254
C YG C++TE +C C + F +T G C ++ C + +C ++
Sbjct: 759 SPPPCTYGR------CENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNS 812
Query: 255 ATGVHC-TCPVGFMLQPDRKTCKDIDECRLNNGGC--DHICRNTVGSFECSCKKGYKLLI 311
C TCP G L R C D+DEC C C NT GSF CSC GY+
Sbjct: 813 PGSFQCRTCPSGHHLH--RGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPS 870
Query: 312 NERN-CQDIDECSFDRTC--DHICVNTPGSFQCLCHRGYLLYGI-THCGDVDECSINRGG 367
C D++EC C C+NT GSF C C GY C DVDECS
Sbjct: 871 GRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS-EEDL 929
Query: 368 CRFG-CINTPGSYQCTCPAGQGRLHWNGKDCTEPL----------------KCQGSPGAS 410
C+ G C NT GS++C CP G H G D L +C+ SPG+
Sbjct: 930 CQSGICTNTDGSFECICPPG----HRAGPDLASCLDVDECRERGPALCGSQRCENSPGSY 985
Query: 411 KAMLSCN---RSGKKDTC 425
+ + C+ +G + TC
Sbjct: 986 RCVRDCDPGYHAGPEGTC 1003
Score = 178 bits (452), Expect = 2e-44
Identities = 150/510 (29%), Positives = 200/510 (39%), Gaps = 81/510 (15%)
Query: 7 PGLCLLVLLVHARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGK 66
PG L V +AA + + QDVDEC + C A C+N P S++C+C +G+ G
Sbjct: 649 PGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSAC 707
Query: 67 HCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS 126
+DVDEC +E C N G++ C C GF G C DVDECA C
Sbjct: 708 E-EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYG 766
Query: 127 -CVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACE-C 184
C N GS++C C GF +T E+ C N C +P G C C
Sbjct: 767 RCENTEGSFQCVCPMGF----QPNTAGSECEDVDECENHLACPGQECVNSP-GSFQCRTC 821
Query: 185 RPGFELTKNQRDCKLTCNYGNGGC--QHTCDDTEQGPRCGCHIKFVLHT-------DGKT 235
G L + + C+ G C C +TE RC C + + D
Sbjct: 822 PSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNE 881
Query: 236 CIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNT 295
C+E G +C + CTC G+ P +C D+DEC + IC NT
Sbjct: 882 CLEGDFCFPHG---ECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNT 938
Query: 296 VGSFECSCKKGYKLLINERNCQDIDEC--------------------------------S 323
GSFEC C G++ + +C D+DEC
Sbjct: 939 DGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAG 998
Query: 324 FDRTCDHI---------------CVNTPGSFQC--LCHRGYLLYGITHCGDVDECSINRG 366
+ TCD + C NTPGS++C C GY C DVDEC NR
Sbjct: 999 PEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECR-NRS 1057
Query: 367 --GCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDT 424
G C N PGS+QC C G +G+ C + +C+ G A L N G +
Sbjct: 1058 FCGAHAVCQNLPGSFQCLCDQGYEGAR-DGRHCVDVNECETLQGVCGAALCENVEG---S 1113
Query: 425 CALTCPSRARFLPESENGFTVSCGTPSPRA 454
CP+ PE + T C P A
Sbjct: 1114 FLCVCPNS----PEEFDPMTGRCVPPRTSA 1139
Score = 174 bits (440), Expect = 5e-43
Identities = 113/368 (30%), Positives = 150/368 (40%), Gaps = 56/368 (15%)
Query: 46 CQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHL 103
C + P Y C C SG+ + G C DVDEC R C N PG++RC C GF
Sbjct: 561 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRA 620
Query: 104 AHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCM 162
CLDVDEC C C N GS+ C C G+ + + +C ++ C
Sbjct: 621 GPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASC----QDVDECT 676
Query: 163 NKNHGCAH-ICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDD-TEQGPR 220
C C+ P G C C GF C+ D+ ++ P
Sbjct: 677 QSPGLCGRGACKNLP-GSFRCVCPAGFR---------------GSACEEDVDECAQEPPP 720
Query: 221 CGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDE 280
CG +C + A HC CP GF + C+D+DE
Sbjct: 721 CG-------------------------PGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDE 755
Query: 281 CRLNNGGCDH-ICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTC-DHICVNTPGS 338
C + C + C NT GSF+C C G++ C+D+DEC C CVN+PGS
Sbjct: 756 CARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGS 815
Query: 339 FQC-LCHRGYLLYGITHCGDVDECSINRGGC--RFGCINTPGSYQCTCPAGQGRLHWNGK 395
FQC C G+ L+ C DVDECS C C NT GS++C+C G
Sbjct: 816 FQCRTCPSGHHLHR-GRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPG 874
Query: 396 DCTEPLKC 403
C + +C
Sbjct: 875 PCADVNEC 882
Score = 114 bits (286), Expect = 3e-25
Identities = 104/346 (30%), Positives = 141/346 (40%), Gaps = 42/346 (12%)
Query: 29 DVDECVE-GTDNCHIDAICQNTPRSYKCI--CKSGYTGD-GKHCKDVDECEREDNAGCVH 84
DVDEC E G + C C+NTP SY+C C GY G C+DVDEC G
Sbjct: 1005 DVDECQEYGPEICGAQR-CENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHA 1063
Query: 85 DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFF 143
C N+PG+++C C G+ A DG +C+DV+EC G C + C N+ GS+ C
Sbjct: 1064 VCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLC------- 1116
Query: 144 LSDNQHTCIQRPEE----GMNCMNKNHGCAHICRETPKGGIA--CECRPGFELTKNQRDC 197
C PEE C+ P+ + RP +
Sbjct: 1117 ------VCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPST 1170
Query: 198 KLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNG---GCD-SKCHD 253
G+G + C P C + + C C V G GC +C
Sbjct: 1171 PRQGPVGSG--RRECYFDTAAPDA-CDNILARNVTWQECC--CTVGEGWGSGCRIQQCPG 1225
Query: 254 AATGVHCT-CPVGF-MLQP--DRKTCKDIDECRL-NNGGCDH-ICRNTVGSFECSCKKGY 307
T + + CP G L P D +D+DEC+L + C +C NT + C C GY
Sbjct: 1226 TETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGY 1285
Query: 308 KLLINERNCQDIDECSFDR-TCD-HICVNTPGSFQCLCHRGYLLYG 351
C D DEC+ + C+ CVNT GS+ C C +L G
Sbjct: 1286 YYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDG 1331
Score = 70.1 bits (170), Expect = 1e-11
Identities = 47/172 (27%), Positives = 70/172 (40%), Gaps = 16/172 (9%)
Query: 40 CHIDAICQNTPRSYKCICKSGY-----TGDGKHCKDVDECEREDNAGCVHD-CVNIPGNY 93
C I Y+ +C G +GD +DVDEC+ + C CVN Y
Sbjct: 1218 CRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGY 1277
Query: 94 RCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFLSDNQHTCI 152
C C +G++ C+D DECA+ C+ CVN +GSY C C L +Q C+
Sbjct: 1278 SCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCV 1337
Query: 153 QRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYG 204
+ ++ N G +C + + C P + +C C YG
Sbjct: 1338 SNESQS---LDDNLG---VCWQEVGADLVCS-HPRLDRQATYTEC--CCLYG 1380
Score = 58.9 bits (141), Expect = 2e-08
Identities = 29/87 (33%), Positives = 42/87 (48%), Gaps = 7/87 (8%)
Query: 70 DVDECEREDNAGCVHD-CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGG----CQ 124
+ +EC D GC + CV +P + C C+DG+ L C+D++EC E
Sbjct: 1533 EAEECGILD--GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1590
Query: 125 QSCVNMMGSYECHCREGFFLSDNQHTC 151
C+N GS+ C CR GF + H C
Sbjct: 1591 ARCLNTDGSFRCICRPGFAPTHQPHHC 1617
Score = 55.1 bits (131), Expect = 3e-07
Identities = 29/72 (40%), Positives = 35/72 (48%), Gaps = 2/72 (2%)
Query: 28 QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGK--HCKDVDECEREDNAGCVHD 85
+DVDEC D +C NT Y C C +GY + C D DEC E+ A
Sbjct: 1252 RDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGR 1311
Query: 86 CVNIPGNYRCTC 97
CVN G+Y CTC
Sbjct: 1312 CVNTVGSYHCTC 1323
Score = 52.4 bits (124), Expect = 2e-06
Identities = 25/76 (32%), Positives = 37/76 (48%), Gaps = 5/76 (6%)
Query: 277 DIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICV--- 333
+ +EC + +G + C F C C GY+L + C DI+EC +CV
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1592
Query: 334 --NTPGSFQCLCHRGY 347
NT GSF+C+C G+
Sbjct: 1593 CLNTDGSFRCICRPGF 1608
Score = 52.0 bits (123), Expect = 3e-06
Identities = 49/174 (28%), Positives = 65/174 (37%), Gaps = 24/174 (13%)
Query: 251 CHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKL 309
C + A G C C G+ R C D DEC C+ C NTVGS+ C+C+ L
Sbjct: 1270 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1329
Query: 310 LINERNC-----QDID--------ECSFDRTCDHICVNTPGSF-QCLCHRGYLLYGITHC 355
++R C Q +D E D C H ++ ++ +C C LYG
Sbjct: 1330 DGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCC-----LYGEAWG 1384
Query: 356 GDVDECSINRGGCRFGCINT--PGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSP 407
D C N P +Y P G G + G D P QG P
Sbjct: 1385 MDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDLGPPY--QGLP 1436
Score = 51.6 bits (122), Expect = 4e-06
Identities = 25/70 (35%), Positives = 35/70 (50%), Gaps = 5/70 (7%)
Query: 46 CQNTPRSYKCICKSGYTGDGKH--CKDVDECEREDNAG--CVH-DCVNIPGNYRCTCYDG 100
C P + C C GY D C D++EC+ + A CV+ C+N G++RC C G
Sbjct: 1548 CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPG 1607
Query: 101 FHLAHDGHNC 110
F H H+C
Sbjct: 1608 FAPTHQPHHC 1617
Score = 50.8 bits (120), Expect = 6e-06
Identities = 39/122 (31%), Positives = 53/122 (43%), Gaps = 12/122 (9%)
Query: 97 CYDGFHLAHDGHNCLDVDECAEGNGGCQQ-SCVNMMGSYECHCREGFFLSDNQHTCIQR- 154
C GF + +C DVDECA G G CQ C N G Y C C +GF L ++ +CI +
Sbjct: 344 CPTGFERVNG--SCEDVDECATG-GRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 400
Query: 155 --PEEGMNCMN--KNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQH 210
E C ++ GC+ I C R G R C+L +G+ G +
Sbjct: 401 VISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVG---KAWGRGCQLCPPFGSEGFRE 457
Query: 211 TC 212
C
Sbjct: 458 IC 459
Score = 48.5 bits (114), Expect = 3e-05
Identities = 24/68 (35%), Positives = 31/68 (45%), Gaps = 3/68 (4%)
Query: 57 CKSGYTGDGKHCKDVDECEREDNAGCVH-DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDE 115
C +G+ C+DVDEC C H +C N G Y C C DGF L +C+
Sbjct: 344 CPTGFERVNGSCEDVDECAT--GGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHV 401
Query: 116 CAEGNGGC 123
+E G C
Sbjct: 402 ISEAKGPC 409
Score = 47.8 bits (112), Expect = 5e-05
Identities = 29/118 (24%), Positives = 47/118 (39%), Gaps = 4/118 (3%)
Query: 203 YGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTC 262
Y + + + + E+ P G + + + E C + +G + +C G C C
Sbjct: 1500 YRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEECGILDGCTNGRCVRVPEGFTCRC 1559
Query: 263 PVGFMLQPDRKTCKDIDECRLNNGG----CDHICRNTVGSFECSCKKGYKLLINERNC 316
G+ L R C DI+EC + C NT GSF C C+ G+ +C
Sbjct: 1560 FDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1617
Score = 45.1 bits (105), Expect = 3e-04
Identities = 33/101 (32%), Positives = 44/101 (43%), Gaps = 13/101 (12%)
Query: 297 GSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITH-- 354
GS+ S + Y+ L E C +D C+ R CV P F C C GY L +T
Sbjct: 1519 GSYAGSLAEPYEELEAEE-CGILDGCTNGR-----CVRVPEGFTCRCFDGYRL-DMTRMA 1571
Query: 355 CGDVDECSINRGGCRF----GCINTPGSYQCTCPAGQGRLH 391
C D++EC C+NT GS++C C G H
Sbjct: 1572 CVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTH 1612
Score = 42.0 bits (97), Expect = 0.003
Identities = 18/48 (37%), Positives = 28/48 (58%), Gaps = 3/48 (6%)
Query: 303 CKKGYKLLINERNCQDIDECSFDRTCDH-ICVNTPGSFQCLCHRGYLL 349
C G++ + +C+D+DEC+ C H C NT G + C+C G+LL
Sbjct: 344 CPTGFERV--NGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLL 389
Score = 41.6 bits (96), Expect = 0.004
Identities = 21/56 (37%), Positives = 29/56 (51%), Gaps = 4/56 (7%)
Query: 262 CPVGFMLQPDRKTCKDIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKLLINERNC 316
CP GF + +C+D+DEC G C H C NT G + C C G+ L + +C
Sbjct: 344 CPTGF--ERVNGSCEDVDECA-TGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC 396
Score = 40.8 bits (94), Expect = 0.006
Identities = 31/134 (23%), Positives = 49/134 (36%), Gaps = 16/134 (11%)
Query: 212 CDDTEQGPRCGCHIKFVLHTDGKTCIET--CAVNNGGCDS-KCHDAATGVHCTCPVGFML 268
C +T G C C + HT CI+ CA C+ +C + HCTC +L
Sbjct: 1270 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1329
Query: 269 QPDRKTCKDIDECRLNNG--------GCDHICRN-----TVGSFECSCKKGYKLLINERN 315
++ C + L++ G D +C + EC C G ++
Sbjct: 1330 DGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCAL 1389
Query: 316 CQDIDECSFDRTCD 329
C D F+ C+
Sbjct: 1390 CPAQDSDDFEALCN 1403
Score = 39.3 bits (90), Expect = 0.019
Identities = 18/33 (54%), Positives = 20/33 (60%), Gaps = 2/33 (6%)
Query: 355 CGDVDECSINRGGCRFG-CINTPGSYQCTCPAG 386
C DVDEC+ G C+ G C NT G Y C CP G
Sbjct: 355 CEDVDECATG-GRCQHGECANTRGGYTCVCPDG 386
Score = 39.3 bits (90), Expect = 0.019
Identities = 24/91 (26%), Positives = 36/91 (39%), Gaps = 9/91 (9%)
Query: 111 LDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPE----EGMNCMNKNH 166
L+ +EC +G CV + + C C +G+ L + C+ E E + + N
Sbjct: 1532 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591
Query: 167 GCAHICRETPKGGIACECRPGFELTKNQRDC 197
C + G C CRPGF T C
Sbjct: 1592 RCLN-----TDGSFRCICRPGFAPTHQPHHC 1617
Score = 36.6 bits (83), Expect = 0.12
Identities = 35/133 (26%), Positives = 47/133 (35%), Gaps = 16/133 (12%)
Query: 184 CRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVN 243
C G L DC+L C+ G + GP C F ++ CA
Sbjct: 311 CCRGAGLAWGVHDCQL-CSERLGNSERV--SAPDGP---CPTGFERVNGSCEDVDECATG 364
Query: 244 NGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKD---IDECR------LNNGGCD-HICR 293
+C + G C CP GF+L R +C I E + L +GGC I R
Sbjct: 365 GRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILR 424
Query: 294 NTVGSFECSCKKG 306
N C + G
Sbjct: 425 NITKQICCCSRVG 437
Score = 34.3 bits (77), Expect = 0.60
Identities = 17/47 (36%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 26 AAQDVDEC--VEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHC 68
A D++EC E ++A C NT S++CIC+ G+ T HC
Sbjct: 1571 ACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1617
Score = 33.9 bits (76), Expect = 0.78
Identities = 53/215 (24%), Positives = 68/215 (31%), Gaps = 40/215 (18%)
Query: 625 CRPGQHRAGTKCVSCPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGSDAHGPLGAT 684
C PG RAG + C H PC G + G C +CP P GA+
Sbjct: 614 CGPG-FRAGPRAAECLDVDECHRVPP---PCDLGRCENTPGSFLC-VCPAGYQAAPHGAS 668
Query: 685 --NVTTCAGQ-------------------CPPG------QHSVDGF-KPCQPCPRGTYQP 716
+V C CP G + VD + PC G
Sbjct: 669 CQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDN 728
Query: 717 EAGRTLCFPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAMGSYQPDFRQ 776
AG C C G ++ GA QD D + P Y RC GS+Q
Sbjct: 729 TAGSFHC-ACPAGFRSRGPGA-PCQDVDECARSPPPCTYG----RCENTE-GSFQCVCPM 781
Query: 777 NFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEF 811
F G+ D D + C ++C G F
Sbjct: 782 GFQPNTAGSECEDVDECENHLACPGQECVNSPGSF 816
Score = 32.7 bits (73), Expect = 1.7
Identities = 15/48 (31%), Positives = 22/48 (45%), Gaps = 2/48 (4%)
Query: 26 AAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDE 73
+ +DVDEC G H + C NT Y C+C G+ D + +
Sbjct: 354 SCEDVDECATGGRCQHGE--CANTRGGYTCVCPDGFLLDSSRSSCISQ 399
>gi|194328809 latent transforming growth factor beta binding protein
3 isoform 1 [Homo sapiens]
Length = 1303
Score = 187 bits (476), Expect = 3e-47
Identities = 116/370 (31%), Positives = 164/370 (44%), Gaps = 61/370 (16%)
Query: 34 VEGTDNCHID------AICQNTPRSYKCICKSGYTGDGKH--CKDVDECEREDNAGCVHD 85
V TD C ++ C P Y C C GY +H C DV+ECE E
Sbjct: 572 VTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGI 631
Query: 86 CVNIPGNYRCTCYDGF--HLAHDGHNCLDVDECAE----GNGGCQQSCVNMMGSYECHCR 139
C+N G+Y C C G+ H+ G +C+D++ECA+ G+GG C+N G Y+C+C
Sbjct: 632 CMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGG---FCINFPGHYKCNCY 688
Query: 140 EGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKL 199
G+ L ++ + +E C + + C P C+PG+
Sbjct: 689 PGYRLKASRPPVCEDIDE---CRDPSSCPDGKCENKPGSFKCIACQPGYR---------- 735
Query: 200 TCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVH 259
+ G G C+ D C E + G C+ +
Sbjct: 736 --SQGGGACR----------------------DVNECAEGSPCSPGWCE----NLPGSFR 767
Query: 260 CTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDI 319
CTC G+ PD ++C D+DEC + + IC NT GSF+C C GY L + +C+DI
Sbjct: 768 CTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDI 827
Query: 320 DECSFDRTC-DHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGC--RFGCINTP 376
DEC F C C+NT GS++CLC +G+ L G C D+DECS + C C N
Sbjct: 828 DECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQ 887
Query: 377 GSYQCTCPAG 386
GSY C C G
Sbjct: 888 GSYVCVCDEG 897
Score = 168 bits (426), Expect = 2e-41
Identities = 171/575 (29%), Positives = 241/575 (41%), Gaps = 97/575 (16%)
Query: 28 QDVDECVEGTDNCHIDAICQNTPRSYKCI-CKSGYTGDGKH-CKDVDECEREDNAGCVHD 85
+D+DEC + + +C D C+N P S+KCI C+ GY G C+DV+EC + + C
Sbjct: 702 EDIDECRDPS-SCP-DGKCENKPGSFKCIACQPGYRSQGGGACRDVNECA--EGSPCSPG 757
Query: 86 -CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFL 144
C N+PG++RCTC G+ A DG +CLDVDEC G+ C N GS++C C G+ L
Sbjct: 758 WCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHL 817
Query: 145 SDNQHTCIQRPE-------EGMNCMNKNHGCAHICRETPK--GGIAC----ECRPGFELT 191
S ++ C E G +C+N N +C + + GG C EC L
Sbjct: 818 SRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLC 877
Query: 192 KNQRDCK-------LTCNYGNGGCQ--HTCDDTEQGP-RCGCHIKFVLHTDGKTCIETCA 241
CK C+ G Q H C++ EQ + C++ F D C A
Sbjct: 878 LPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNF---DDTVFCDSVLA 934
Query: 242 VNNGGCDSKCH-DAATGVHCT---CPVG-----FMLQPDRK--------------TCKDI 278
N + C A G HC CPV L PD K +DI
Sbjct: 935 TNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDI 994
Query: 279 DECRLNNGGC--DHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDH-ICVNT 335
DEC L + C NT +EC CK+G+ N C D+DEC + C + +C NT
Sbjct: 995 DECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENT 1054
Query: 336 PGSFQCLCHR-GYLLYGITHC-----GDVDECSINRGGCRFG-CINTPGSYQCTCPAGQG 388
G ++C C C DVDEC + CR G C+N PGSY+C C
Sbjct: 1055 RGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQ-DPAACRPGRCVNLPGSYRCEC----- 1108
Query: 389 RLHW----NGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPSRARFLPE----SE 440
R W +G+DC P + + + ++ G+ CA A +
Sbjct: 1109 RPPWVPGPSGRDCQLP-ESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQG 1167
Query: 441 NGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEAAVLSIKQR--ASFKIKDAKCRLHLRN 498
G+ C PR A + + + +NS +L R S + +CR
Sbjct: 1168 RGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRC---- 1223
Query: 499 KGKTEEAGR-ITGPGGAPCSECQVTFIHLKCDSSR 532
+GR + PGGA C EC F + D+SR
Sbjct: 1224 -----VSGRCVPRPGGAVC-ECPGGF---QLDASR 1249
Score = 157 bits (398), Expect = 4e-38
Identities = 110/354 (31%), Positives = 156/354 (44%), Gaps = 61/354 (17%)
Query: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGC 82
++ DVDEC G D C + IC NTP S++C C SGY + D HC+D+DEC+ A C
Sbjct: 781 RSCLDVDECEAG-DVCD-NGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFP--AAC 836
Query: 83 VH-DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGC--QQSCVNMMGSYECHCR 139
+ DC+N G+YRC C G L G C D+DEC++ C +C N+ GSY C C
Sbjct: 837 IGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCD 895
Query: 140 EGFFLSDNQHTC--IQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC 197
EGF + +QH C +++P C + C+ +T+ + C
Sbjct: 896 EGFTPTQDQHGCEEVEQPHHKKECYLNFDDT-----------VFCDSVLATNVTQQECCC 944
Query: 198 KLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHT---DGKTCIETCAVNNGGC------- 247
L +G D E P C + H+ DGK + + N G
Sbjct: 945 SLGAGWG--------DHCEIYP-CPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDID 995
Query: 248 -----------DSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDH-ICRNT 295
+ KC + G C C GF + C D+DEC L+ C + +C NT
Sbjct: 996 ECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC-LDESNCRNGVCENT 1054
Query: 296 VGSFECSCKKGYKLLINERNC-----QDIDECSFDRTC-DHICVNTPGSFQCLC 343
G + C+C + +R C D+DEC C CVN PGS++C C
Sbjct: 1055 RGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCEC 1108
Score = 150 bits (378), Expect = 7e-36
Identities = 125/465 (26%), Positives = 181/465 (38%), Gaps = 76/465 (16%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT----GDGKHCKDVDECEREDNAGCVH 84
DV+EC E IC NT SY C C GY G+ C D++EC + G
Sbjct: 616 DVNEC-EAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGG 674
Query: 85 DCVNIPGNYRCTCYDGFHL-AHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFF 143
C+N PG+Y+C CY G+ L A C D+DEC + + C N GS++C + +
Sbjct: 675 FCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGY 734
Query: 144 LSDNQHTC--IQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT- 200
S C + EG C C P G C C G+ + R C
Sbjct: 735 RSQGGGACRDVNECAEGSPC------SPGWCENLP-GSFRCTCAQGYAPAPDGRSCLDVD 787
Query: 201 -CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAATG 257
C G+ C +T +C C + L D C I+ C C +
Sbjct: 788 ECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGS 847
Query: 258 VHCTCPVGFMLQPDRKTCKDIDECRLNNGGC--DHICRNTVGSFECSCKKGYKLLINERN 315
C CP G L RK C+DIDEC + C C+N GS+ C C +G+ ++
Sbjct: 848 YRCLCPQGHRLVGGRK-CQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHG 906
Query: 316 CQDID------EC--SFDRT--CDHICVNTPGSFQCLCH--------------------- 344
C++++ EC +FD T CD + +C C
Sbjct: 907 CEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAE 966
Query: 345 --------RGY------LLYGITHCGDVDECSI-NRGGCRFG-CINTPGSYQCTCPAGQG 388
+GY + YGI D+DEC + C+ G C+NT Y+C C G
Sbjct: 967 FHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQG-- 1024
Query: 389 RLHWNGK--DCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPS 431
+++G +C + +C + R G + CA T P+
Sbjct: 1025 -FYYDGNLLECVDVDECLDESNCRNGVCENTRGGYR--CACTPPA 1066
Score = 113 bits (282), Expect = 1e-24
Identities = 98/328 (29%), Positives = 120/328 (36%), Gaps = 75/328 (22%)
Query: 26 AAQDVDECVE-GTDNCHIDAICQNTPRSYKCICKSGYTGDGK--HCKDVDECEREDNAGC 82
A +D+DEC+ G++ C + C NT Y+C CK G+ DG C DVDEC E N C
Sbjct: 990 AHRDIDECMLFGSEICK-EGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN--C 1046
Query: 83 VHD-CVNIPGNYRCTCYDGFHLAHDGHNCL-----DVDECAEGNGGCQQSCVNMMGSYEC 136
+ C N G YRC C + CL DVDEC + CVN+ GSY C
Sbjct: 1047 RNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRC 1106
Query: 137 HCREGFFLSDNQHTC------------------IQRPEEGM--------------NCMNK 164
CR + + C QR E+GM C +
Sbjct: 1107 ECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQ 1166
Query: 165 NHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQ-GPRCGC 223
G CR P G C + + D T G D +E+ C C
Sbjct: 1167 GRGWGAQCRPCPPRGAGSHCPTSQSESNSFWD---TSPLLLGKPPRDEDSSEEDSDECRC 1223
Query: 224 HIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECR- 282
+C G C CP GF L R C DIDECR
Sbjct: 1224 -----------------------VSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE 1260
Query: 283 LNNGGC---DHICRNTVGSFECSCKKGY 307
LN G C NT GSF C CK G+
Sbjct: 1261 LNQRGLLCKSERCVNTSGSFRCVCKAGF 1288
Score = 101 bits (251), Expect = 4e-21
Identities = 114/452 (25%), Positives = 160/452 (35%), Gaps = 100/452 (22%)
Query: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTG--DGKHCKDVD---------- 72
+ QD+DEC + C C+N SY C+C G+T D C++V+
Sbjct: 862 RKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYL 921
Query: 73 -------------------ECEREDNAGCVHDCVNIP------GNYRCTCYDGFHLAHDG 107
EC AG C P + C DG D
Sbjct: 922 NFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDN 981
Query: 108 HNC-------LDVDECAE-GNGGCQQS-CVNMMGSYECHCREGFFLSDNQHTCIQRPEEG 158
+ D+DEC G+ C++ CVN YEC+C++GF+ N C+ E
Sbjct: 982 NIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDE-- 1039
Query: 159 MNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHT------- 211
C+++++ +C T +GG C C P E + QR C CQ
Sbjct: 1040 --CLDESNCRNGVCENT-RGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGR 1096
Query: 212 CDDTEQGPRCGCHIKFVLHTDGKTCI-------------ETCAVNNGGCDSKCHDAATGV 258
C + RC C +V G+ C + C G D C G
Sbjct: 1097 CVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGE-DGMCAGPLAGP 1155
Query: 259 -----HCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLIN- 312
C C G + C G H T S S LL+
Sbjct: 1156 ALTFDDCCCRQGRGWGAQCRPCPP-------RGAGSHC--PTSQSESNSFWDTSPLLLGK 1206
Query: 313 -----ERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGI-THCGDVDEC-SINR 365
+ + +D DEC R CV PG C C G+ L C D+DEC +N+
Sbjct: 1207 PPRDEDSSEEDSDEC---RCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQ 1263
Query: 366 GG--CRFG-CINTPGSYQCTCPAGQGRLHWNG 394
G C+ C+NT GS++C C AG R +G
Sbjct: 1264 RGLLCKSERCVNTSGSFRCVCKAGFARSRPHG 1295
Score = 59.3 bits (142), Expect = 2e-08
Identities = 36/94 (38%), Positives = 45/94 (47%), Gaps = 6/94 (6%)
Query: 65 GKHCKDVDECERE-DNAGCVHD-CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGG 122
GK +D D E + D CV CV PG C C GF L C+D+DEC E N
Sbjct: 1205 GKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1264
Query: 123 ---CQ-QSCVNMMGSYECHCREGFFLSDNQHTCI 152
C+ + CVN GS+ C C+ GF S C+
Sbjct: 1265 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1298
Score = 53.9 bits (128), Expect = 7e-07
Identities = 23/45 (51%), Positives = 30/45 (66%), Gaps = 2/45 (4%)
Query: 343 CHRGYLLYGITHCGDVDECSINRGGCRFG-CINTPGSYQCTCPAG 386
C +GY THC D++EC++ G CR G C+N PGSY+C CP G
Sbjct: 341 CPQGYKRLNSTHCQDINECAMP-GVCRHGDCLNNPGSYRCVCPPG 384
Score = 52.8 bits (125), Expect = 2e-06
Identities = 24/54 (44%), Positives = 33/54 (61%), Gaps = 2/54 (3%)
Query: 297 GSFECSCKKGYKLLINERNCQDIDECSFDRTCDH-ICVNTPGSFQCLCHRGYLL 349
G C +GYK L N +CQDI+EC+ C H C+N PGS++C+C G+ L
Sbjct: 335 GEVGADCPQGYKRL-NSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
Score = 45.8 bits (107), Expect = 2e-04
Identities = 27/86 (31%), Positives = 38/86 (44%), Gaps = 5/86 (5%)
Query: 89 IPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQ 148
+ G C G+ + H C D++ECA C+N GSY C C G L ++
Sbjct: 333 VRGEVGADCPQGYKRLNSTH-CQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391
Query: 149 HTCI-QRPEEGMNC---MNKNHGCAH 170
CI +PEE C ++ H C H
Sbjct: 392 TQCIADKPEEKSLCFRLVSPEHQCQH 417
Score = 44.3 bits (103), Expect = 6e-04
Identities = 22/57 (38%), Positives = 29/57 (50%), Gaps = 4/57 (7%)
Query: 57 CKSGYTG-DGKHCKDVDECEREDNAGCVH-DCVNIPGNYRCTCYDGFHLAHDGHNCL 111
C GY + HC+D++EC C H DC+N PG+YRC C G L C+
Sbjct: 341 CPQGYKRLNSTHCQDINECAMP--GVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI 395
Score = 38.1 bits (87), Expect = 0.041
Identities = 29/119 (24%), Positives = 41/119 (34%), Gaps = 10/119 (8%)
Query: 694 PPGQHSVDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAI-SFQDCDTKVQCSPG 752
PP +D + CP G + + G C C G ++ GA +C CSPG
Sbjct: 698 PPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPG 757
Query: 753 HYYNTSIHRCIRCAMGSYQPDFRQNFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEF 811
N GS++ Q + G + D D + C N C G F
Sbjct: 758 WCENLP---------GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSF 807
Score = 37.7 bits (86), Expect = 0.054
Identities = 32/101 (31%), Positives = 42/101 (41%), Gaps = 19/101 (18%)
Query: 233 GKTCIETCAVNNGGC--DSKCHDAA----TGVH----------CTCPVGFMLQPDRKTCK 276
G T E C + G SKCH TGV CP G+ + + C+
Sbjct: 296 GLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYK-RLNSTHCQ 354
Query: 277 DIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKLLINERNC 316
DI+EC + G C H C N GS+ C C G+ L + C
Sbjct: 355 DINECAMP-GVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
Score = 32.0 bits (71), Expect = 3.0
Identities = 15/39 (38%), Positives = 21/39 (53%), Gaps = 2/39 (5%)
Query: 24 SKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT 62
S QD++EC H D C N P SY+C+C G++
Sbjct: 350 STHCQDINECAMPGVCRHGD--CLNNPGSYRCVCPPGHS 386
>gi|18497288 latent transforming growth factor beta binding protein
3 isoform 2 [Homo sapiens]
Length = 1256
Score = 187 bits (476), Expect = 3e-47
Identities = 116/370 (31%), Positives = 164/370 (44%), Gaps = 61/370 (16%)
Query: 34 VEGTDNCHID------AICQNTPRSYKCICKSGYTGDGKH--CKDVDECEREDNAGCVHD 85
V TD C ++ C P Y C C GY +H C DV+ECE E
Sbjct: 572 VTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGI 631
Query: 86 CVNIPGNYRCTCYDGF--HLAHDGHNCLDVDECAE----GNGGCQQSCVNMMGSYECHCR 139
C+N G+Y C C G+ H+ G +C+D++ECA+ G+GG C+N G Y+C+C
Sbjct: 632 CMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGG---FCINFPGHYKCNCY 688
Query: 140 EGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKL 199
G+ L ++ + +E C + + C P C+PG+
Sbjct: 689 PGYRLKASRPPVCEDIDE---CRDPSSCPDGKCENKPGSFKCIACQPGYR---------- 735
Query: 200 TCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVH 259
+ G G C+ D C E + G C+ +
Sbjct: 736 --SQGGGACR----------------------DVNECAEGSPCSPGWCE----NLPGSFR 767
Query: 260 CTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDI 319
CTC G+ PD ++C D+DEC + + IC NT GSF+C C GY L + +C+DI
Sbjct: 768 CTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDI 827
Query: 320 DECSFDRTC-DHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGC--RFGCINTP 376
DEC F C C+NT GS++CLC +G+ L G C D+DECS + C C N
Sbjct: 828 DECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQ 887
Query: 377 GSYQCTCPAG 386
GSY C C G
Sbjct: 888 GSYVCVCDEG 897
Score = 150 bits (378), Expect = 7e-36
Identities = 125/465 (26%), Positives = 181/465 (38%), Gaps = 76/465 (16%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT----GDGKHCKDVDECEREDNAGCVH 84
DV+EC E IC NT SY C C GY G+ C D++EC + G
Sbjct: 616 DVNEC-EAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGG 674
Query: 85 DCVNIPGNYRCTCYDGFHL-AHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFF 143
C+N PG+Y+C CY G+ L A C D+DEC + + C N GS++C + +
Sbjct: 675 FCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGY 734
Query: 144 LSDNQHTC--IQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT- 200
S C + EG C C P G C C G+ + R C
Sbjct: 735 RSQGGGACRDVNECAEGSPC------SPGWCENLP-GSFRCTCAQGYAPAPDGRSCLDVD 787
Query: 201 -CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAATG 257
C G+ C +T +C C + L D C I+ C C +
Sbjct: 788 ECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGS 847
Query: 258 VHCTCPVGFMLQPDRKTCKDIDECRLNNGGC--DHICRNTVGSFECSCKKGYKLLINERN 315
C CP G L RK C+DIDEC + C C+N GS+ C C +G+ ++
Sbjct: 848 YRCLCPQGHRLVGGRK-CQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHG 906
Query: 316 CQDID------EC--SFDRT--CDHICVNTPGSFQCLCH--------------------- 344
C++++ EC +FD T CD + +C C
Sbjct: 907 CEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAE 966
Query: 345 --------RGY------LLYGITHCGDVDECSI-NRGGCRFG-CINTPGSYQCTCPAGQG 388
+GY + YGI D+DEC + C+ G C+NT Y+C C G
Sbjct: 967 FHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQG-- 1024
Query: 389 RLHWNGK--DCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPS 431
+++G +C + +C + R G + CA T P+
Sbjct: 1025 -FYYDGNLLECVDVDECLDESNCRNGVCENTRGGYR--CACTPPA 1066
Score = 148 bits (374), Expect = 2e-35
Identities = 119/368 (32%), Positives = 165/368 (44%), Gaps = 59/368 (16%)
Query: 28 QDVDECVEGTDNCHIDAICQNTPRSYKCI-CKSGYTGDGKH-CKDVDECEREDNAGCVHD 85
+D+DEC + + +C D C+N P S+KCI C+ GY G C+DV+EC + + C
Sbjct: 702 EDIDECRDPS-SCP-DGKCENKPGSFKCIACQPGYRSQGGGACRDVNECA--EGSPCSPG 757
Query: 86 -CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFL 144
C N+PG++RCTC G+ A DG +CLDVDEC G+ C N GS++C C G+ L
Sbjct: 758 WCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHL 817
Query: 145 SDNQHTCIQRPE-------EGMNCMNKNHGCAHICRETPK--GGIAC----ECRPGFELT 191
S ++ C E G +C+N N +C + + GG C EC L
Sbjct: 818 SRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLC 877
Query: 192 KNQRDCK-------LTCNYGNGGCQ--HTCDDTEQGP-RCGCHIKFVLHTDGKTCIETCA 241
CK C+ G Q H C++ EQ + C++ F D C A
Sbjct: 878 LPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNF---DDTVFCDSVLA 934
Query: 242 VNNGGCDSKCH-DAATGVHCT---CPVG-----FMLQPDRK--------------TCKDI 278
N + C A G HC CPV L PD K +DI
Sbjct: 935 TNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDI 994
Query: 279 DECRLNNGGC--DHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTC-DHICVNT 335
DEC L + C NT +EC CK+G+ N C D+DEC + C + +C NT
Sbjct: 995 DECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENT 1054
Query: 336 PGSFQCLC 343
G ++C C
Sbjct: 1055 RGGYRCAC 1062
Score = 141 bits (355), Expect = 3e-33
Identities = 128/476 (26%), Positives = 182/476 (38%), Gaps = 114/476 (23%)
Query: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGC 82
++ DVDEC G D C + IC NTP S++C C SGY + D HC+D+DEC+ A C
Sbjct: 781 RSCLDVDECEAG-DVCD-NGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFP--AAC 836
Query: 83 VH-DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGC--QQSCVNMMGSYECHCR 139
+ DC+N G+YRC C G L G C D+DEC++ C +C N+ GSY C C
Sbjct: 837 IGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCD 895
Query: 140 EGFFLSDNQHTC--IQRPEEGMNC-------------MNKNHGCAHICRETPKG-GIACE 183
EGF + +QH C +++P C + N C G G CE
Sbjct: 896 EGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCE 955
Query: 184 CRP-----------------GFELTKN--------QRDCKLTCNYGNGGCQH-TCDDTEQ 217
P G+ N RD +G+ C+ C +T+
Sbjct: 956 IYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQP 1015
Query: 218 GPRCGCHIKFVLHTDGKTCIET--CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTC 275
G C C F + C++ C + + C + G C C P ++ C
Sbjct: 1016 GYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQC 1075
Query: 276 KDIDECRL---------NNGGCDHICRNTVGS-----FECSCKKGYKLLINERNC----- 316
+E + G D +C + +C C++G R C
Sbjct: 1076 LSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGA 1135
Query: 317 ---------------------------------QDIDECSFDRTCDHICVNTPGSFQCLC 343
+D DEC R CV PG C C
Sbjct: 1136 GSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDEC---RCVSGRCVPRPGGAVCEC 1192
Query: 344 HRGYLLYGI-THCGDVDEC-SINRGG--CRFG-CINTPGSYQCTCPAGQGRLHWNG 394
G+ L C D+DEC +N+ G C+ C+NT GS++C C AG R +G
Sbjct: 1193 PGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHG 1248
Score = 59.3 bits (142), Expect = 2e-08
Identities = 36/94 (38%), Positives = 45/94 (47%), Gaps = 6/94 (6%)
Query: 65 GKHCKDVDECERE-DNAGCVHD-CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGG 122
GK +D D E + D CV CV PG C C GF L C+D+DEC E N
Sbjct: 1158 GKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQR 1217
Query: 123 ---CQ-QSCVNMMGSYECHCREGFFLSDNQHTCI 152
C+ + CVN GS+ C C+ GF S C+
Sbjct: 1218 GLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1251
Score = 53.9 bits (128), Expect = 7e-07
Identities = 23/45 (51%), Positives = 30/45 (66%), Gaps = 2/45 (4%)
Query: 343 CHRGYLLYGITHCGDVDECSINRGGCRFG-CINTPGSYQCTCPAG 386
C +GY THC D++EC++ G CR G C+N PGSY+C CP G
Sbjct: 341 CPQGYKRLNSTHCQDINECAMP-GVCRHGDCLNNPGSYRCVCPPG 384
Score = 52.8 bits (125), Expect = 2e-06
Identities = 24/54 (44%), Positives = 33/54 (61%), Gaps = 2/54 (3%)
Query: 297 GSFECSCKKGYKLLINERNCQDIDECSFDRTCDH-ICVNTPGSFQCLCHRGYLL 349
G C +GYK L N +CQDI+EC+ C H C+N PGS++C+C G+ L
Sbjct: 335 GEVGADCPQGYKRL-NSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL 387
Score = 45.8 bits (107), Expect = 2e-04
Identities = 27/86 (31%), Positives = 38/86 (44%), Gaps = 5/86 (5%)
Query: 89 IPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQ 148
+ G C G+ + H C D++ECA C+N GSY C C G L ++
Sbjct: 333 VRGEVGADCPQGYKRLNSTH-CQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391
Query: 149 HTCI-QRPEEGMNC---MNKNHGCAH 170
CI +PEE C ++ H C H
Sbjct: 392 TQCIADKPEEKSLCFRLVSPEHQCQH 417
Score = 44.3 bits (103), Expect = 6e-04
Identities = 22/57 (38%), Positives = 29/57 (50%), Gaps = 4/57 (7%)
Query: 57 CKSGYTG-DGKHCKDVDECEREDNAGCVH-DCVNIPGNYRCTCYDGFHLAHDGHNCL 111
C GY + HC+D++EC C H DC+N PG+YRC C G L C+
Sbjct: 341 CPQGYKRLNSTHCQDINECAMP--GVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI 395
Score = 38.1 bits (87), Expect = 0.041
Identities = 29/119 (24%), Positives = 41/119 (34%), Gaps = 10/119 (8%)
Query: 694 PPGQHSVDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAI-SFQDCDTKVQCSPG 752
PP +D + CP G + + G C C G ++ GA +C CSPG
Sbjct: 698 PPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPG 757
Query: 753 HYYNTSIHRCIRCAMGSYQPDFRQNFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEF 811
N GS++ Q + G + D D + C N C G F
Sbjct: 758 WCENLP---------GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSF 807
Score = 37.7 bits (86), Expect = 0.054
Identities = 32/101 (31%), Positives = 42/101 (41%), Gaps = 19/101 (18%)
Query: 233 GKTCIETCAVNNGGC--DSKCHDAA----TGVH----------CTCPVGFMLQPDRKTCK 276
G T E C + G SKCH TGV CP G+ + + C+
Sbjct: 296 GLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYK-RLNSTHCQ 354
Query: 277 DIDECRLNNGGCDH-ICRNTVGSFECSCKKGYKLLINERNC 316
DI+EC + G C H C N GS+ C C G+ L + C
Sbjct: 355 DINECAMP-GVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC 394
Score = 32.0 bits (71), Expect = 3.0
Identities = 15/39 (38%), Positives = 21/39 (53%), Gaps = 2/39 (5%)
Query: 24 SKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT 62
S QD++EC H D C N P SY+C+C G++
Sbjct: 350 STHCQDINECAMPGVCRHGD--CLNNPGSYRCVCPPGHS 386
>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
Length = 1231
Score = 184 bits (468), Expect = 3e-46
Identities = 144/513 (28%), Positives = 204/513 (39%), Gaps = 113/513 (22%)
Query: 24 SKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVD-----ECER 76
S D DEC+ +C NT SY C C G++ DG+ C+ E +
Sbjct: 599 SLPGDDQDECLLLPGEL-CQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQ 657
Query: 77 E--------------------------DNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNC 110
E DN C C + G+ C+C+ G+ + DG +C
Sbjct: 658 EPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSC 717
Query: 111 LDVDECAEGNGGC--QQSCVNMMGSYEC-----HCREGFFLSDNQ------------HTC 151
D DEC G C +Q CVN +GS+ C C +G+ L+ ++ HTC
Sbjct: 718 EDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTC 777
Query: 152 IQRPEEGMNCMNKNH----------------------GCA---HICR-----ETPKGGIA 181
R E +N + H CA H C+ + KG
Sbjct: 778 -SRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFY 836
Query: 182 CE----CRPGF------------ELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHI 225
C+ C GF E T C+ + N +TC ++ P C
Sbjct: 837 CQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTC---QRNPLI-CAR 892
Query: 226 KFVLHTDGKTCIET----CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDEC 281
+ DG C++ V+ G CH+ C C GF + C D++EC
Sbjct: 893 GYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNEC 952
Query: 282 RLNNGG-CDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQ 340
+ G C H C NT+GS+ CSC G+ L + + C+D++EC R C C N GS+Q
Sbjct: 953 WASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQR-CSQECANIYGSYQ 1011
Query: 341 CLCHRGYLLYGITH-CGDVDECSINRG-GCRFGCINTPGSYQCTCPAGQGRLHWNGKDCT 398
C C +GY L H C D+DEC+ G C F C+N PGSYQC CP + NG+ C
Sbjct: 1012 CYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCK 1071
Query: 399 EPLKCQ-GSPGASKAMLSCNRSGKKDTCALTCP 430
+ +C G+ S+A N G CP
Sbjct: 1072 DVDECALGTHNCSEAETCHNIQGSFRCLRFECP 1104
Score = 184 bits (466), Expect = 5e-46
Identities = 120/358 (33%), Positives = 165/358 (46%), Gaps = 39/358 (10%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCI----CKSGYTGDGKHCKDVDECEREDNAGCVH 84
D++ECV C C NT S+ C C+ GY C+DVDEC + C
Sbjct: 766 DINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHT-CQP 824
Query: 85 D--CVNIPGNYRCT----CYDGFHLAHDGHNCLDVDECAEGNGGCQQ--SCVNMMGSYEC 136
C N G++ C C DGF +G NC+D++EC + C+ SC+N +GSY C
Sbjct: 825 GFLCQNTKGSFYCQARQRCMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVGSYTC 883
Query: 137 H-----CREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAH--ICRETPKGGIACECRPGFE 189
C G+ SD+ C+ E C H C +C P G C+C+ GF+
Sbjct: 884 QRNPLICARGYHASDDGTKCVDVNE----CETGVHRCGEGQVCHNLP-GSYRCDCKAGFQ 938
Query: 190 LTKNQRDCKLTCN--YGNGG--CQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNG 245
R C + N + + G CQHTC++T RC C F+L DGK C +
Sbjct: 939 RDAFGRGC-IDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQ 997
Query: 246 GCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNG-GCDHICRNTVGSFECSC- 303
C +C + C C G+ L D TC DIDEC G C C N GS++C+C
Sbjct: 998 RCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACP 1057
Query: 304 KKGYKLLINERNCQDIDECSF-DRTCD--HICVNTPGSFQCL---CHRGYLLYGITHC 355
++GY + N R+C+D+DEC+ C C N GSF+CL C Y+ T C
Sbjct: 1058 EQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKC 1115
Score = 117 bits (294), Expect = 4e-26
Identities = 135/512 (26%), Positives = 186/512 (36%), Gaps = 92/512 (17%)
Query: 15 LVHARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCI-------CKSGYTGDGKH 67
L+ A + A D DEC+E ++ D +C+ R + C+ C +G G
Sbjct: 441 LIETCCAAGQQWAIDNDECLEIPESGTEDNVCRTAQR-HCCVSYLQEKSCMAGVLG---- 495
Query: 68 CKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSC 127
K+ + C EDN C +++ C G + +G +C E N C
Sbjct: 496 AKEGETCGAEDNDSCG---ISLYKQCCDCCGLGLRVRAEGQSC-------ESNPNLGYPC 545
Query: 128 VNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPG 187
++M S C E + + ++RP E + RE G E P
Sbjct: 546 NHVMLSC-CEGEEPLIVPE-----VRRPPEPAAAPRRVSEAEMAGREALSLGTEAEL-PN 598
Query: 188 FELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC----------- 236
+Q +C L CQH C +T C C F L DG+TC
Sbjct: 599 SLPGDDQDECLLL---PGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEA 655
Query: 237 ------------------------IETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDR 272
TC +NG C C C+C G+ + D
Sbjct: 656 PQEPALKSEFSQVASNTIPLPLPQPNTCK-DNGPCKQVCSTVGGSAICSCFPGYAIMADG 714
Query: 273 KTCKDIDECRLNNGGCD--HICRNTVGSFEC-----SCKKGYKLLINERNCQDIDECSFD 325
+C+D DEC + C C NT+GSF C C GY +L R C DI+EC D
Sbjct: 715 VSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGY-ILNAHRKCVDINECVTD 773
Query: 326 -RTCD--HICVNTPGSFQC----LCHRGYLLYGITHCGDVDECSINRGGCR--FGCINTP 376
TC CVNT GSF C C GY L C DVDEC++ C+ F C NT
Sbjct: 774 LHTCSRGEHCVNTLGSFHCYKALTCEPGYALKD-GECEDVDECAMGTHTCQPGFLCQNTK 832
Query: 377 GSYQCTC--PAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPSRAR 434
GS+ C G L +C + +C + SC + TC AR
Sbjct: 833 GSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICAR 892
Query: 435 FLPESENGFTV----SCGTPSPRAAPARAGHN 462
S++G C T R + HN
Sbjct: 893 GYHASDDGTKCVDVNECETGVHRCGEGQVCHN 924
Score = 37.4 bits (85), Expect = 0.070
Identities = 20/60 (33%), Positives = 27/60 (45%), Gaps = 9/60 (15%)
Query: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCI---CKSGYTGDGK------HCKDVDECE 75
++ +DVDEC GT NC C N S++C+ C Y K C D EC+
Sbjct: 1068 RSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQ 1127
Score = 30.8 bits (68), Expect = 6.6
Identities = 50/177 (28%), Positives = 64/177 (36%), Gaps = 45/177 (25%)
Query: 625 CRPGQHRA--GTKCVS---CPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPG--SDA 677
C G H + GTKCV C G + G+ + C P G CD G DA
Sbjct: 890 CARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLP--------GSYRCDCKAGFQRDA 941
Query: 678 HGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGA 737
G G +V C PG + CQ T + G C C G +G
Sbjct: 942 FGR-GCIDVNECWAS--PG-------RLCQH----TCENTLGSYRC-SCASGFLLAADG- 985
Query: 738 ISFQDCDTKVQCSPGHYYNTSIHRCIR-CA--MGSYQPDFRQNFCSRCPGNTSTDFD 791
+ C+ +C RC + CA GSYQ RQ + G+T TD D
Sbjct: 986 ---KRCEDVNECEA--------QRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDID 1031
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 167 bits (422), Expect = 6e-41
Identities = 131/412 (31%), Positives = 179/412 (43%), Gaps = 48/412 (11%)
Query: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCI--CKSGY--TGDGKHCKDVDECEREDNA 80
+ QD+DEC G CH C NT SY+C+ C SG+ T DG C+D++EC+ +++
Sbjct: 5143 RTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQ--ESS 5200
Query: 81 GCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECH--C 138
C C N G++ C C G+ L G C+DV+EC + Q C N G Y+C C
Sbjct: 5201 PCHQRCFNAIGSFHCGCEPGYQLK--GRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLC 5258
Query: 139 REGFFLSDNQHTCIQRPEEGMNCMNKNHGCAH--ICRETPKGGIACECRPGFELTKNQRD 196
G ++N TCI E C + H C + IC T +G C C G+ R
Sbjct: 5259 PNGMTKAENG-TCIDIDE----CKDGTHQCRYNQICENT-RGSYRCVCPRGYRSQGVGRP 5312
Query: 197 CK--LTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDA 254
C C C H C +T +C C L DGK+C + N G ++
Sbjct: 5313 CMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNL 5372
Query: 255 ATGVHCTCPVGFMLQPDRK------TCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYK 308
A PV QP + E R + R + +C +G +
Sbjct: 5373 AR----FSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRR----TIRKTCPEGSE 5424
Query: 309 LLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGY-LLYGITHCGDVDEC---SIN 364
+ C DIDEC C H C NT GS+QC+C GY L + C D+DEC +++
Sbjct: 5425 A--SHDTCVDIDECENTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVH 5482
Query: 365 RGGCRFGCINTPGSYQC---TCPAGQGRLHWNG---KDC-TEPLKCQGSPGA 409
G R C N GSYQC CP R +G K+C L+C SP A
Sbjct: 5483 CGPNRM-CFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYA 5533
Score = 155 bits (391), Expect = 2e-37
Identities = 118/361 (32%), Positives = 154/361 (42%), Gaps = 74/361 (20%)
Query: 4 GRVPGLCLLVLLVHARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTG 63
GR+P LV +HA S D ++ +E T I A RS +C SG+T
Sbjct: 5050 GRMP---FLVETLHA-----SSVESDYNQ-IEETLGFKIHASISKGDRSNQC--PSGFTL 5098
Query: 64 D--GKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNG 121
D G C D DEC + C H C N G Y C+C G +A DG C D+DECA G
Sbjct: 5099 DSVGPFCADEDECAAGNP--CSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRH 5156
Query: 122 GCQ--QSCVNMMGSYEC--HCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPK 177
C Q C N +GSY C C GF +R +G++C + N C+E
Sbjct: 5157 TCHAGQDCDNTIGSYRCVVRCGSGF----------RRTSDGLSCQDINE-----CQE--- 5198
Query: 178 GGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCI 237
+ C C + CGC + L G+ C+
Sbjct: 5199 ---------------------------SSPCHQRCFNAIGSFHCGCEPGYQL--KGRKCM 5229
Query: 238 ET--CAVNNGGCDSKCHDAATGVHC--TCPVGFMLQPDRKTCKDIDECRLNNGGC--DHI 291
+ C N D C + G C CP G M + + TC DIDEC+ C + I
Sbjct: 5230 DVNECRQNVCRPDQHCKNTRGGYKCIDLCPNG-MTKAENGTCIDIDECKDGTHQCRYNQI 5288
Query: 292 CRNTVGSFECSCKKGYKLLINERNCQDIDEC-SFDRTCDHICVNTPGSFQCLCHRGYLLY 350
C NT GS+ C C +GY+ R C DI+EC + C H C NTPGSF+C+C G L
Sbjct: 5289 CENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLL 5348
Query: 351 G 351
G
Sbjct: 5349 G 5349
Score = 100 bits (248), Expect = 9e-21
Identities = 64/188 (34%), Positives = 88/188 (46%), Gaps = 18/188 (9%)
Query: 262 CPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDE 321
CP GF L C D DEC N C H C N +G++ CSC KG + + R CQDIDE
Sbjct: 5092 CPSGFTLDSVGPFCADEDECAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDE 5150
Query: 322 CSFDRTCDHI---CVNTPGSFQCL--CHRGY--LLYGITHCGDVDECSINRGGCRFGCIN 374
C+ R H C NT GS++C+ C G+ G++ C D++EC C C N
Sbjct: 5151 CALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLS-CQDINECQ-ESSPCHQRCFN 5208
Query: 375 TPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPSRAR 434
GS+ C C G G+ C + +C+ + R G K C CP+
Sbjct: 5209 AIGSFHCGCEPG---YQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYK--CIDLCPNG-- 5261
Query: 435 FLPESENG 442
+ ++ENG
Sbjct: 5262 -MTKAENG 5268
Score = 37.0 bits (84), Expect = 0.092
Identities = 67/299 (22%), Positives = 86/299 (28%), Gaps = 102/299 (34%)
Query: 625 CRPGQH----RAGTKCVS-CPQGTYYHGQTEQCVP---CPAGTFQEREGQL--------- 667
CRP QH R G KC+ CP G + C+ C GT Q R Q+
Sbjct: 5239 CRPDQHCKNTRGGYKCIDLCPNGMT-KAENGTCIDIDECKDGTHQCRYNQICENTRGSYR 5297
Query: 668 --------------------SCDLCPGSDAHGPLGATNVTTCAGQCPPGQHSVDGFKPCQ 707
C+ P AH C CPPGQH + K C
Sbjct: 5298 CVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCI--CPPGQHLLGDGKSCA 5355
Query: 708 PCP--------------------RGTYQPE-------------------------AGRTL 722
R YQP+ RT+
Sbjct: 5356 GLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTI 5415
Query: 723 CFPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAMGSYQPDFRQNFCSRC 782
C G H+ + +C+ C H C + GSYQ +
Sbjct: 5416 RKTCPEGSEASHDTCVDIDECENTDACQ---------HEC-KNTFGSYQCICPPGYQLTH 5465
Query: 783 PGNTSTDFDG--STSVAQCKNRQCGGELGEFTGYIESPNYPGNY---PAGVECIWNINP 836
G T D D +V NR C G + I++P P NY P C+ N P
Sbjct: 5466 NGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQ-CIDTP-CPPNYQRDPVSGFCLKNCPP 5522
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 162 bits (410), Expect = 1e-39
Identities = 114/330 (34%), Positives = 146/330 (44%), Gaps = 56/330 (16%)
Query: 57 CKSGYTGD--GKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVD 114
C G+ D G C D DEC + C H C+N PG + CTC GF LA D NC DVD
Sbjct: 3428 CPEGFELDSQGAFCVDRDECSGGPSP-CSHACLNAPGRFSCTCPTGFALAWDDRNCRDVD 3486
Query: 115 ECAEGNGGCQ--QSCVNMMGSYEC--HCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAH 170
ECA C+ Q CVN++GSY C C GF ++D E+ C+ C +
Sbjct: 3487 ECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGAGC-----EDVDECLEGLDDCHY 3541
Query: 171 --ICRETPKGGIACECRPGFELTKNQRDC--KLTCNYGNGGCQHTCDDTEQGPRCGCHIK 226
+C TP GG C C G+ + C C C + C + + RC C
Sbjct: 3542 NQLCENTP-GGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPG 3600
Query: 227 FVLHTDGKTCIETCAVNNG-GCDSKCHDA-------------ATGVH------------- 259
L DGK C T NG + H T H
Sbjct: 3601 QTLLRDGKAC--TSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALS 3658
Query: 260 ----CTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERN 315
CP GF+ Q C D+DECR+ N C H CRNT GS++C C GY+LL + +N
Sbjct: 3659 SVGRAWCPPGFIRQ--NGVCTDLDECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPSGKN 3715
Query: 316 CQDIDEC---SFDRTCDHICVNTPGSFQCL 342
CQDI+EC S + +C NT GS+QC+
Sbjct: 3716 CQDINECEEESIECGPGQMCFNTRGSYQCV 3745
Score = 134 bits (338), Expect = 3e-31
Identities = 95/312 (30%), Positives = 127/312 (40%), Gaps = 49/312 (15%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAGCVHD- 85
D DEC G C C N P + C C +G+ D ++C+DVDEC + + C
Sbjct: 3443 DRDECSGGPSPC--SHACLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHL-CREGQ 3499
Query: 86 -CVNIPGNYRCT--CYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMGSYECHCRE 140
CVN+ G+YRC C GF +A DG C DVDEC EG C Q C N G + C C
Sbjct: 3500 RCVNLLGSYRCLPDCGPGFRVA-DGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCPR 3558
Query: 141 GFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT 200
G+ + C+ E C+ CA+ C +G C C PG L ++ + C
Sbjct: 3559 GYRMQGPSLPCLDVNE----CLQLPKACAYQCHNL-QGSYRCLCPPGQTLLRDGKACTSL 3613
Query: 201 CNYGN----------------------GGCQHTCDDTEQGP-------RCGCHIKFVLHT 231
G G H GP R C F+
Sbjct: 3614 ERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQN 3673
Query: 232 DGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGC--D 289
T ++ C V N C C + C CP G+ L P K C+DI+EC + C
Sbjct: 3674 GVCTDLDECRVRNL-CQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPG 3732
Query: 290 HICRNTVGSFEC 301
+C NT GS++C
Sbjct: 3733 QMCFNTRGSYQC 3744
Score = 118 bits (296), Expect = 2e-26
Identities = 101/364 (27%), Positives = 140/364 (38%), Gaps = 59/364 (16%)
Query: 135 ECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQ 194
E C EGF L C+ R E C C+H C P G +C C GF L +
Sbjct: 3425 EVGCPEGFELDSQGAFCVDRDE----CSGGPSPCSHACLNAP-GRFSCTCPTGFALAWDD 3479
Query: 195 RDCKLT---------CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVN 243
R+C+ C G C + P CG + DG C ++ C
Sbjct: 3480 RNCRDVDECAWDAHLCREGQR-CVNLLGSYRCLPDCGPGFRVA---DGAGCEDVDECLEG 3535
Query: 244 NGGC--DSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFEC 301
C + C + G C+CP G+ +Q C D++EC C + C N GS+ C
Sbjct: 3536 LDDCHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRC 3595
Query: 302 SCKKGYKLLINERNCQDIDE---------------------CSFDRTCDHICVN-TPGSF 339
C G LL + + C ++ S T H V+ PG
Sbjct: 3596 LCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPM 3655
Query: 340 ------QCLCHRGYLLY-GITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHW 392
+ C G++ G+ C D+DEC + R C+ C NT GSYQC CPAG RL
Sbjct: 3656 ALSSVGRAWCPPGFIRQNGV--CTDLDECRV-RNLCQHACRNTEGSYQCLCPAGY-RLLP 3711
Query: 393 NGKDCTEPLKC-QGSPGASKAMLSCNRSGKKDTCALTCPSRARFLPESENGF---TVSCG 448
+GK+C + +C + S + N G CP+ R P F + CG
Sbjct: 3712 SGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCFRRCSQDCG 3771
Query: 449 TPSP 452
T P
Sbjct: 3772 TGGP 3775
Score = 68.2 bits (165), Expect = 4e-11
Identities = 36/103 (34%), Positives = 49/103 (47%), Gaps = 7/103 (6%)
Query: 57 CKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDEC 116
C G+ C D+DEC + C H C N G+Y+C C G+ L G NC D++EC
Sbjct: 3665 CPPGFIRQNGVCTDLDECRVRNL--CQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINEC 3722
Query: 117 AEGNGGC--QQSCVNMMGSYEC---HCREGFFLSDNQHTCIQR 154
E + C Q C N GSY+C C + + TC +R
Sbjct: 3723 EEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCFRR 3765
Score = 32.0 bits (71), Expect = 3.0
Identities = 13/32 (40%), Positives = 19/32 (59%)
Query: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCI 56
K QD++EC E + C +C NT SY+C+
Sbjct: 3714 KNCQDINECEEESIECGPGQMCFNTRGSYQCV 3745
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 162 bits (410), Expect = 1e-39
Identities = 114/330 (34%), Positives = 146/330 (44%), Gaps = 56/330 (16%)
Query: 57 CKSGYTGD--GKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVD 114
C G+ D G C D DEC + C H C+N PG + CTC GF LA D NC DVD
Sbjct: 4619 CPEGFELDSQGAFCVDRDECSGGPSP-CSHACLNAPGRFSCTCPTGFALAWDDRNCRDVD 4677
Query: 115 ECAEGNGGCQ--QSCVNMMGSYEC--HCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAH 170
ECA C+ Q CVN++GSY C C GF ++D E+ C+ C +
Sbjct: 4678 ECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGAGC-----EDVDECLEGLDDCHY 4732
Query: 171 --ICRETPKGGIACECRPGFELTKNQRDC--KLTCNYGNGGCQHTCDDTEQGPRCGCHIK 226
+C TP GG C C G+ + C C C + C + + RC C
Sbjct: 4733 NQLCENTP-GGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPG 4791
Query: 227 FVLHTDGKTCIETCAVNNG-GCDSKCHDA-------------ATGVH------------- 259
L DGK C T NG + H T H
Sbjct: 4792 QTLLRDGKAC--TSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALS 4849
Query: 260 ----CTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERN 315
CP GF+ Q C D+DECR+ N C H CRNT GS++C C GY+LL + +N
Sbjct: 4850 SVGRAWCPPGFIRQ--NGVCTDLDECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPSGKN 4906
Query: 316 CQDIDEC---SFDRTCDHICVNTPGSFQCL 342
CQDI+EC S + +C NT GS+QC+
Sbjct: 4907 CQDINECEEESIECGPGQMCFNTRGSYQCV 4936
Score = 134 bits (338), Expect = 3e-31
Identities = 95/312 (30%), Positives = 127/312 (40%), Gaps = 49/312 (15%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAGCVHD- 85
D DEC G C C N P + C C +G+ D ++C+DVDEC + + C
Sbjct: 4634 DRDECSGGPSPC--SHACLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHL-CREGQ 4690
Query: 86 -CVNIPGNYRCT--CYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMGSYECHCRE 140
CVN+ G+YRC C GF +A DG C DVDEC EG C Q C N G + C C
Sbjct: 4691 RCVNLLGSYRCLPDCGPGFRVA-DGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCPR 4749
Query: 141 GFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT 200
G+ + C+ E C+ CA+ C +G C C PG L ++ + C
Sbjct: 4750 GYRMQGPSLPCLDVNE----CLQLPKACAYQCHNL-QGSYRCLCPPGQTLLRDGKACTSL 4804
Query: 201 CNYGN----------------------GGCQHTCDDTEQGP-------RCGCHIKFVLHT 231
G G H GP R C F+
Sbjct: 4805 ERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQN 4864
Query: 232 DGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGC--D 289
T ++ C V N C C + C CP G+ L P K C+DI+EC + C
Sbjct: 4865 GVCTDLDECRVRNL-CQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPG 4923
Query: 290 HICRNTVGSFEC 301
+C NT GS++C
Sbjct: 4924 QMCFNTRGSYQC 4935
Score = 118 bits (296), Expect = 2e-26
Identities = 101/364 (27%), Positives = 140/364 (38%), Gaps = 59/364 (16%)
Query: 135 ECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQ 194
E C EGF L C+ R E C C+H C P G +C C GF L +
Sbjct: 4616 EVGCPEGFELDSQGAFCVDRDE----CSGGPSPCSHACLNAP-GRFSCTCPTGFALAWDD 4670
Query: 195 RDCKLT---------CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVN 243
R+C+ C G C + P CG + DG C ++ C
Sbjct: 4671 RNCRDVDECAWDAHLCREGQR-CVNLLGSYRCLPDCGPGFRVA---DGAGCEDVDECLEG 4726
Query: 244 NGGC--DSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFEC 301
C + C + G C+CP G+ +Q C D++EC C + C N GS+ C
Sbjct: 4727 LDDCHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRC 4786
Query: 302 SCKKGYKLLINERNCQDIDE---------------------CSFDRTCDHICVN-TPGSF 339
C G LL + + C ++ S T H V+ PG
Sbjct: 4787 LCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPM 4846
Query: 340 ------QCLCHRGYLLY-GITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHW 392
+ C G++ G+ C D+DEC + R C+ C NT GSYQC CPAG RL
Sbjct: 4847 ALSSVGRAWCPPGFIRQNGV--CTDLDECRV-RNLCQHACRNTEGSYQCLCPAGY-RLLP 4902
Query: 393 NGKDCTEPLKC-QGSPGASKAMLSCNRSGKKDTCALTCPSRARFLPESENGF---TVSCG 448
+GK+C + +C + S + N G CP+ R P F + CG
Sbjct: 4903 SGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCFRRCSQDCG 4962
Query: 449 TPSP 452
T P
Sbjct: 4963 TGGP 4966
Score = 68.2 bits (165), Expect = 4e-11
Identities = 36/103 (34%), Positives = 49/103 (47%), Gaps = 7/103 (6%)
Query: 57 CKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDEC 116
C G+ C D+DEC + C H C N G+Y+C C G+ L G NC D++EC
Sbjct: 4856 CPPGFIRQNGVCTDLDECRVRNL--CQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINEC 4913
Query: 117 AEGNGGC--QQSCVNMMGSYEC---HCREGFFLSDNQHTCIQR 154
E + C Q C N GSY+C C + + TC +R
Sbjct: 4914 EEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCFRR 4956
Score = 32.0 bits (71), Expect = 3.0
Identities = 13/32 (40%), Positives = 19/32 (59%)
Query: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCI 56
K QD++EC E + C +C NT SY+C+
Sbjct: 4905 KNCQDINECEEESIECGPGQMCFNTRGSYQCV 4936
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 162 bits (410), Expect = 1e-39
Identities = 114/330 (34%), Positives = 146/330 (44%), Gaps = 56/330 (16%)
Query: 57 CKSGYTGD--GKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVD 114
C G+ D G C D DEC + C H C+N PG + CTC GF LA D NC DVD
Sbjct: 3337 CPEGFELDSQGAFCVDRDECSGGPSP-CSHACLNAPGRFSCTCPTGFALAWDDRNCRDVD 3395
Query: 115 ECAEGNGGCQ--QSCVNMMGSYEC--HCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAH 170
ECA C+ Q CVN++GSY C C GF ++D E+ C+ C +
Sbjct: 3396 ECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGAGC-----EDVDECLEGLDDCHY 3450
Query: 171 --ICRETPKGGIACECRPGFELTKNQRDC--KLTCNYGNGGCQHTCDDTEQGPRCGCHIK 226
+C TP GG C C G+ + C C C + C + + RC C
Sbjct: 3451 NQLCENTP-GGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRCLCPPG 3509
Query: 227 FVLHTDGKTCIETCAVNNG-GCDSKCHDA-------------ATGVH------------- 259
L DGK C T NG + H T H
Sbjct: 3510 QTLLRDGKAC--TSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALS 3567
Query: 260 ----CTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERN 315
CP GF+ Q C D+DECR+ N C H CRNT GS++C C GY+LL + +N
Sbjct: 3568 SVGRAWCPPGFIRQ--NGVCTDLDECRVRN-LCQHACRNTEGSYQCLCPAGYRLLPSGKN 3624
Query: 316 CQDIDEC---SFDRTCDHICVNTPGSFQCL 342
CQDI+EC S + +C NT GS+QC+
Sbjct: 3625 CQDINECEEESIECGPGQMCFNTRGSYQCV 3654
Score = 134 bits (338), Expect = 3e-31
Identities = 95/312 (30%), Positives = 127/312 (40%), Gaps = 49/312 (15%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAGCVHD- 85
D DEC G C C N P + C C +G+ D ++C+DVDEC + + C
Sbjct: 3352 DRDECSGGPSPC--SHACLNAPGRFSCTCPTGFALAWDDRNCRDVDECAWDAHL-CREGQ 3408
Query: 86 -CVNIPGNYRCT--CYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMGSYECHCRE 140
CVN+ G+YRC C GF +A DG C DVDEC EG C Q C N G + C C
Sbjct: 3409 RCVNLLGSYRCLPDCGPGFRVA-DGAGCEDVDECLEGLDDCHYNQLCENTPGGHRCSCPR 3467
Query: 141 GFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT 200
G+ + C+ E C+ CA+ C +G C C PG L ++ + C
Sbjct: 3468 GYRMQGPSLPCLDVNE----CLQLPKACAYQCHNL-QGSYRCLCPPGQTLLRDGKACTSL 3522
Query: 201 CNYGN----------------------GGCQHTCDDTEQGP-------RCGCHIKFVLHT 231
G G H GP R C F+
Sbjct: 3523 ERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPMALSSVGRAWCPPGFIRQN 3582
Query: 232 DGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGC--D 289
T ++ C V N C C + C CP G+ L P K C+DI+EC + C
Sbjct: 3583 GVCTDLDECRVRNL-CQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINECEEESIECGPG 3641
Query: 290 HICRNTVGSFEC 301
+C NT GS++C
Sbjct: 3642 QMCFNTRGSYQC 3653
Score = 118 bits (296), Expect = 2e-26
Identities = 101/364 (27%), Positives = 140/364 (38%), Gaps = 59/364 (16%)
Query: 135 ECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQ 194
E C EGF L C+ R E C C+H C P G +C C GF L +
Sbjct: 3334 EVGCPEGFELDSQGAFCVDRDE----CSGGPSPCSHACLNAP-GRFSCTCPTGFALAWDD 3388
Query: 195 RDCKLT---------CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVN 243
R+C+ C G C + P CG + DG C ++ C
Sbjct: 3389 RNCRDVDECAWDAHLCREGQR-CVNLLGSYRCLPDCGPGFRVA---DGAGCEDVDECLEG 3444
Query: 244 NGGC--DSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFEC 301
C + C + G C+CP G+ +Q C D++EC C + C N GS+ C
Sbjct: 3445 LDDCHYNQLCENTPGGHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQCHNLQGSYRC 3504
Query: 302 SCKKGYKLLINERNCQDIDE---------------------CSFDRTCDHICVN-TPGSF 339
C G LL + + C ++ S T H V+ PG
Sbjct: 3505 LCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWVSLRPGPM 3564
Query: 340 ------QCLCHRGYLLY-GITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHW 392
+ C G++ G+ C D+DEC + R C+ C NT GSYQC CPAG RL
Sbjct: 3565 ALSSVGRAWCPPGFIRQNGV--CTDLDECRV-RNLCQHACRNTEGSYQCLCPAGY-RLLP 3620
Query: 393 NGKDCTEPLKC-QGSPGASKAMLSCNRSGKKDTCALTCPSRARFLPESENGF---TVSCG 448
+GK+C + +C + S + N G CP+ R P F + CG
Sbjct: 3621 SGKNCQDINECEEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCFRRCSQDCG 3680
Query: 449 TPSP 452
T P
Sbjct: 3681 TGGP 3684
Score = 68.2 bits (165), Expect = 4e-11
Identities = 36/103 (34%), Positives = 49/103 (47%), Gaps = 7/103 (6%)
Query: 57 CKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDEC 116
C G+ C D+DEC + C H C N G+Y+C C G+ L G NC D++EC
Sbjct: 3574 CPPGFIRQNGVCTDLDECRVRNL--CQHACRNTEGSYQCLCPAGYRLLPSGKNCQDINEC 3631
Query: 117 AEGNGGC--QQSCVNMMGSYEC---HCREGFFLSDNQHTCIQR 154
E + C Q C N GSY+C C + + TC +R
Sbjct: 3632 EEESIECGPGQMCFNTRGSYQCVDTPCPATYRQGPSPGTCFRR 3674
Score = 32.0 bits (71), Expect = 3.0
Identities = 13/32 (40%), Positives = 19/32 (59%)
Query: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCI 56
K QD++EC E + C +C NT SY+C+
Sbjct: 3623 KNCQDINECEEESIECGPGQMCFNTRGSYQCV 3654
>gi|19743803 fibulin 5 precursor [Homo sapiens]
Length = 448
Score = 146 bits (369), Expect = 8e-35
Identities = 101/328 (30%), Positives = 141/328 (42%), Gaps = 59/328 (17%)
Query: 86 CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMGSYECHCREGFF 143
C+ PGN + C +GF L CLD+DEC C+ CVN G Y
Sbjct: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGY--------- 66
Query: 144 LSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCK-LTCN 202
CI R N TP G P + L C
Sbjct: 67 ------LCIPRTNPVYRGPYSNP------YSTPYSGPYPAAAPPLSAPNYPTISRPLICR 114
Query: 203 YGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIET--CAVNNGGCDSK--CHDAATGV 258
+G + D++ Q C++ CA ++ C+ C + G
Sbjct: 115 FG-----YQMDESNQ------------------CVDVDECATDSHQCNPTQICINTEGGY 151
Query: 259 HCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQD 318
C+C G+ L + C DIDECR G C +C N GS+ C+C G+ L + R+CQD
Sbjct: 152 TCSCTDGYWLLEGQ--CLDIDECRY--GYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQD 207
Query: 319 IDECSFDRTCDHICVNTPGSFQCLCHRGYLLY--GITHCGDVDECSINRGGCRFGCINTP 376
++EC+ + C CVNT GSF C C GY L G+ HC D+DECS + C+ C+N P
Sbjct: 208 VNECATENPCVQTCVNTYGSFICRCDPGYELEEDGV-HCSDMDECSFSEFLCQHECVNQP 266
Query: 377 GSYQCTCPAGQGRLHWNGKDCTEPLKCQ 404
G+Y C+CP G L N + C + +C+
Sbjct: 267 GTYFCSCPPGYILLDDN-RSCQDINECE 293
Score = 137 bits (344), Expect = 7e-32
Identities = 83/232 (35%), Positives = 107/232 (46%), Gaps = 20/232 (8%)
Query: 24 SKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCV 83
S DVDEC + C+ IC NT Y C C GY C D+DEC C
Sbjct: 122 SNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECR---YGYCQ 178
Query: 84 HDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFF 143
C N+PG+Y CTC GF L DG +C DV+ECA N C Q+CVN GS+ C C G+
Sbjct: 179 QLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATEN-PCVQTCVNTYGSFICRCDPGYE 237
Query: 144 LSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCK--LTC 201
L ++ C E C C H C P G C C PG+ L + R C+ C
Sbjct: 238 LEEDGVHCSDMDE----CSFSEFLCQHECVNQP-GTYFCSCPPGYILLDDNRSCQDINEC 292
Query: 202 NYGNGGC--QHTCDDTEQGPRC----GCHIKFVLHTDGKTCIETCAVNNGGC 247
+ N C Q TC + + G +C C ++ +D + C+ C N GC
Sbjct: 293 EHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNR-CM--CPAENPGC 341
Score = 126 bits (317), Expect = 9e-29
Identities = 89/303 (29%), Positives = 132/303 (43%), Gaps = 27/303 (8%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSG--YTGDGKHCKDVDECEREDNAGCVHDC 86
D+DEC + C D +C N Y CI ++ Y G + A
Sbjct: 42 DIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSA 101
Query: 87 VNIPGNYR-CTCYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMGSYECHCREGFF 143
N P R C G+ + + + C+DVDECA + C Q C+N G Y C C +G++
Sbjct: 102 PNYPTISRPLICRFGYQM-DESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYW 160
Query: 144 LSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT--C 201
L + Q I G C +C P G +C C PGF L ++ R C+ C
Sbjct: 161 LLEGQCLDIDECRYGY--------CQQLCANVP-GSYSCTCNPGFTLNEDGRSCQDVNEC 211
Query: 202 NYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAATGVH 259
N C TC +T C C + L DG C ++ C+ + C +C +
Sbjct: 212 ATENP-CVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYF 270
Query: 260 CTCPVGFMLQPDRKTCKDIDECRLNNGGCD--HICRNTVGSFEC----SCKKGYKLLINE 313
C+CP G++L D ++C+DI+EC N C+ C N G F+C C++ Y L I++
Sbjct: 271 CSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPY-LRISD 329
Query: 314 RNC 316
C
Sbjct: 330 NRC 332
Score = 117 bits (293), Expect = 5e-26
Identities = 67/190 (35%), Positives = 94/190 (49%), Gaps = 24/190 (12%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAGCVHDC 86
D+DEC G + +C N P SY C C G+T DG+ C+DV+EC E+ CV C
Sbjct: 168 DIDECRYG----YCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENP--CVQTC 221
Query: 87 VNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSD 146
VN G++ C C G+ L DG +C D+DEC+ CQ CVN G+Y C C G+ L D
Sbjct: 222 VNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLD 281
Query: 147 NQHTCIQRPEEGMNCMNKNHGC--AHICRETPKGGIAC----EC-RPGFELTKNQRDCKL 199
+ +C ++ C ++NH C C +GG C C P ++ N +
Sbjct: 282 DNRSC----QDINECEHRNHTCNLQQTCYNL-QGGFKCIDPIRCEEPYLRISDN----RC 332
Query: 200 TCNYGNGGCQ 209
C N GC+
Sbjct: 333 MCPAENPGCR 342
Score = 51.6 bits (122), Expect = 4e-06
Identities = 40/157 (25%), Positives = 53/157 (33%), Gaps = 48/157 (30%)
Query: 291 ICRNTVGSFECSCKKGYKLLINERNCQDIDEC-SFDRTC--DHICVNTPGSFQC------ 341
+C + G+ + C G+ L C DIDEC + C D +CVN G + C
Sbjct: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
Query: 342 -------------------------------------LCHRGYLLYGITHCGDVDECSIN 364
+C GY + C DVDEC+ +
Sbjct: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATD 134
Query: 365 RGGCRFG--CINTPGSYQCTCPAGQGRLHWNGKDCTE 399
C CINT G Y C+C G L D E
Sbjct: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDE 171
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 145 bits (366), Expect = 2e-34
Identities = 75/229 (32%), Positives = 114/229 (49%), Gaps = 5/229 (2%)
Query: 573 RQRMERRLKGSLKMLRKSINQDRFLLRLAGLDYELAHKPGLVAGERAEPMESCRPGQHRA 632
+QR+ + L+ L++++N+D + +A L ++A P CRPG
Sbjct: 939 QQRLLQTLETITNKLKRTLNKDPMYSFQLASEILIADSNSLET-KKASPF--CRPGSVLR 995
Query: 633 GTKCVSCPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGSDAHGPLGATNVTTCAGQ 692
G CV+CP GTYY+ + C C G++Q+ EGQL C LCP + + N++ C Q
Sbjct: 996 GRMCVNCPLGTYYNLEHFTCESCRIGSYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQ 1055
Query: 693 CPPGQHSVDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAISFQDCDTKVQCSPG 752
C G +S G + C+ CP GTYQP+ G C C +T GA++ C V C G
Sbjct: 1056 CKQGTYSYSGLETCESCPLGTYQPKFGSRSCLSCPENTSTVKRGAVNISACG--VPCPEG 1113
Query: 753 HYYNTSIHRCIRCAMGSYQPDFRQNFCSRCPGNTSTDFDGSTSVAQCKN 801
+ + + C C YQP+ + FC CP +T F GS S+ +C +
Sbjct: 1114 KFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSITECSS 1162
Score = 82.4 bits (202), Expect = 2e-15
Identities = 73/240 (30%), Positives = 97/240 (40%), Gaps = 41/240 (17%)
Query: 40 CHIDAICQNTPRSYKCICKSGYTGDGKHCK-DVDECEREDNAGCVHD--CVNIPGNYRCT 96
CH CQ R Y C+C GYT G C+ D+DEC C+++ C ++ G + C
Sbjct: 1202 CHNSGTCQQLGRGYVCLCPLGYT--GLKCETDIDEC---SPLPCLNNGVCKDLVGEFICE 1256
Query: 97 CYDGFHLAHDGHNCLD-VDECAEGNGGCQQSCVNMMGSYECHCREGF---FLSDNQHTCI 152
C G+ G C + ++EC+ + CV+ + Y C C +GF + C
Sbjct: 1257 CPSGY----TGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQ 1312
Query: 153 QRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELT---KNQRDCKLTCNYGNGGCQ 209
P C+N N C E GG C+C PGF T KN +C L+ NG
Sbjct: 1313 SNP-----CLN-NAVC-----EDQVGGFLCKCPPGFLGTRCGKNVDEC-LSQPCKNGA-- 1358
Query: 210 HTCDDTEQGPRCGCHIKFVLHTDGKTC---IETCAVNNGGCDSKCHDAATGVHCTCPVGF 266
TC D RC C F G C I C N + C D C C GF
Sbjct: 1359 -TCKDGANSFRCLCAAGFT----GSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGF 1413
Score = 79.3 bits (194), Expect = 2e-14
Identities = 89/358 (24%), Positives = 136/358 (37%), Gaps = 46/358 (12%)
Query: 38 DNCHIDAICQNTPRSYKC-ICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRC- 95
++C I + Q+ +C +C SG + H +++ +C+ A C + G C
Sbjct: 1016 ESCRIGSY-QDEEGQLECKLCPSGMYTEYIHSRNISDCK----AQCKQGTYSYSGLETCE 1070
Query: 96 TCYDGFHLAHDG-HNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQR 154
+C G + G +CL C E ++ VN+ + C EG F C
Sbjct: 1071 SCPLGTYQPKFGSRSCLS---CPENTSTVKRGAVNI-SACGVPCPEGKFSRSGLMPC--- 1123
Query: 155 PEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDD 214
H C + G C P + T +T ++
Sbjct: 1124 -----------HPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSITECSSFSSTFSAAEE 1172
Query: 215 TEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKT 274
+ P HIK H C N C G C CP+G+ K
Sbjct: 1173 SVVPPASLGHIK-KRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLCPLGY---TGLKC 1228
Query: 275 CKDIDECR----LNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDH 330
DIDEC LNNG +C++ VG F C C GY +R ++I+ECS +
Sbjct: 1229 ETDIDECSPLPCLNNG----VCKDLVGEFICECPSGY---TGQRCEENINECSSSPCLNK 1281
Query: 331 -ICVNTPGSFQCLCHRGYLLYGITHC-GDVDECSINRGGCRFGCINTPGSYQCTCPAG 386
ICV+ ++C C +G++ G+ HC +V+EC N C + G + C CP G
Sbjct: 1282 GICVDGVAGYRCTCVKGFV--GL-HCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPG 1336
Score = 72.8 bits (177), Expect = 2e-12
Identities = 63/233 (27%), Positives = 97/233 (41%), Gaps = 42/233 (18%)
Query: 179 GIACECRPGFELTKNQRD---CKLTCNYGNGGCQHT-------CDDTEQGPRCGCHIKFV 228
G C C G+ K + D C NG C+ C G RC +I
Sbjct: 1214 GYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENIN-- 1271
Query: 229 LHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCK-DIDECRLNNGG 287
C + +N G C D G CTC GF+ C+ +++EC+ N
Sbjct: 1272 ------ECSSSPCLNKG----ICVDGVAGYRCTCVKGFV----GLHCETEVNECQSNPCL 1317
Query: 288 CDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDH--ICVNTPGSFQCLCHR 345
+ +C + VG F C C G+ + R +++DEC + C + C + SF+CLC
Sbjct: 1318 NNAVCEDQVGGFLCKCPPGF---LGTRCGKNVDEC-LSQPCKNGATCKDGANSFRCLCAA 1373
Query: 346 GYLLYGITHCG-DVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDC 397
G+ +HC +++EC N + C++ SY C C G ++GK C
Sbjct: 1374 GFT---GSHCELNINECQSNPCRNQATCVDELNSYSCKCQPG-----FSGKRC 1418
Score = 53.5 bits (127), Expect = 9e-07
Identities = 29/83 (34%), Positives = 40/83 (48%), Gaps = 4/83 (4%)
Query: 24 SKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCV 83
S + DVDEC G+D C A C N SY C C YTGDGK+C + +C+ N
Sbjct: 1740 SPSCLDVDECAVGSD-CSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENG 1798
Query: 84 H---DCVNIPGNYRCTCYDGFHL 103
H + + +C +G+ L
Sbjct: 1799 HSSGEIYTVGAEVTFSCQEGYQL 1821
Score = 46.2 bits (108), Expect = 2e-04
Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 4/71 (5%)
Query: 622 MESCRPGQHRAGTKCVSCPQGTYYHGQTEQCVPCPAGTFQER---EGQLSCDLCPGSDAH 678
M SC+ G H +C+ C +G Y G +C CP+GT++ G SC CP +
Sbjct: 291 MGSCKCGTHTGHFECI-CEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHT 349
Query: 679 GPLGATNVTTC 689
P G+T+ C
Sbjct: 350 SPPGSTSPEDC 360
Score = 45.4 bits (106), Expect = 3e-04
Identities = 29/83 (34%), Positives = 40/83 (48%), Gaps = 22/83 (26%)
Query: 343 CHRGYLLYGITH---------------CGDVDECSINRGGCRFG-CINTPGSYQCTC-PA 385
C+ GY L G + C DVDEC++ C+N GSY C+C P
Sbjct: 1716 CNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPP 1775
Query: 386 GQGRLHWNGKDCTEPLKCQGSPG 408
G +GK+C EP+KC+ +PG
Sbjct: 1776 YTG----DGKNCAEPIKCK-APG 1793
Score = 45.1 bits (105), Expect = 3e-04
Identities = 29/107 (27%), Positives = 45/107 (42%), Gaps = 7/107 (6%)
Query: 55 CICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVD 114
C + G C DVDEC + C+N+ G+Y C+C + DG NC +
Sbjct: 1730 CTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPY--TGDGKNCAEPI 1787
Query: 115 EC-AEG---NGGCQQSCVNMMGSYECHCREGF-FLSDNQHTCIQRPE 156
+C A G NG + C+EG+ + + TC++ E
Sbjct: 1788 KCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGE 1834
Score = 40.8 bits (94), Expect = 0.006
Identities = 39/137 (28%), Positives = 53/137 (38%), Gaps = 18/137 (13%)
Query: 656 PAGTFQEREGQLSCDLCP-GSDAHGPLGATNVTTCAGQ----CPPGQHSVDGFKPCQPCP 710
P+G+F + + LC G D +G+ T G C G + C CP
Sbjct: 265 PSGSFIQDDMVHCSYLCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACP 324
Query: 711 RGTYQPE---AGRTLCFPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAM 767
GTY+PE G + C PC T G+ S +DC C G Y S C
Sbjct: 325 SGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDC----VCREG--YRASGQTCELVHC 378
Query: 768 GSYQPD----FRQNFCS 780
+ +P F QN C+
Sbjct: 379 PALKPPENGYFIQNTCN 395
Score = 40.0 bits (92), Expect = 0.011
Identities = 22/50 (44%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 91 GNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQ--SCVNMMGSYECHC 138
G+ R C D +CLDVDECA G+ C + SC+N+ GSY C C
Sbjct: 1724 GDSRMFCTDNGSWNGVSPSCLDVDECAVGS-DCSEHASCLNVDGSYICSC 1772
Score = 38.9 bits (89), Expect = 0.024
Identities = 63/279 (22%), Positives = 99/279 (35%), Gaps = 43/279 (15%)
Query: 103 LAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTC------IQRPE 156
+ H + C + +C + G C+ C G +EC C +G++ Q+ C +PE
Sbjct: 274 MVHCSYLCDEGKDCCDRMGSCK--CGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPE 331
Query: 157 EGMNCMNKNHGCAHICRETPKGGIA---CECRPGFELTKNQRD---CKLTCNYGNG-GCQ 209
++ C +P G + C CR G+ + + C NG Q
Sbjct: 332 GSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQ 391
Query: 210 HTCDDTEQGPRCG--CHIKFVLHTDGKTCIETCAVNN--GGCDSKCHDAATGVHCTCPVG 265
+TC++ CG CH F L + I C N G +S C TCP
Sbjct: 392 NTCNN-HFNAACGVRCHPGFDL---VGSSIILCLPNGLWSGSESYCRVR------TCP-- 439
Query: 266 FMLQPDRKTCKDIDECRLNNGGCDHIC---RNTVGSFECSCK-----KGYKLLINERNCQ 317
+ QP L C C GS + +C+ G + ER+C
Sbjct: 440 HLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCS 499
Query: 318 DIDECSFDRTCDHICVNTPGSFQCLCH----RGYLLYGI 352
H C P F +C+ +G++L G+
Sbjct: 500 TFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGV 538
Score = 38.5 bits (88), Expect = 0.032
Identities = 66/307 (21%), Positives = 110/307 (35%), Gaps = 50/307 (16%)
Query: 33 CVEGTDNCHIDAICQNTPRS--YKCICKSGYTGDGKHCKDVDEC--------EREDNAGC 82
C EG D C C+ + ++CIC+ GY G G EC + E + G
Sbjct: 281 CDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQY----ECTACPSGTYKPEGSPGG 336
Query: 83 VHDCVNIPGNYR-----------CTCYDGFHLAHDGHNCLDVDEC----AEGNGGCQQSC 127
+ C+ P C C +G+ + G C ++ C NG Q+
Sbjct: 337 ISSCIPCPDENHTSPPGSTSPEDCVCREGYRAS--GQTC-ELVHCPALKPPENGYFIQNT 393
Query: 128 VNMMGSYEC--HCREGF-FLSDNQHTCIQRP-EEGMNCMNKNHGCAHICRETPKGGIACE 183
N + C C GF + + C+ G + C H+ R+ G I+C
Sbjct: 394 CNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHL-RQPKHGHISCS 452
Query: 184 CRPGFELTKNQRDCKLTCNYG---NGGCQHTCDDTEQ--GPRCGCHIKFVLHTDGKTCIE 238
R T C + C+ G G + TC Q GP C + H +
Sbjct: 453 TREMLYKT----TCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVER---HCSTFQMPK 505
Query: 239 TCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGS 298
++ C + T + +C GF+L ++ + + N G +C++ V +
Sbjct: 506 DVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKD-VEA 564
Query: 299 FECSCKK 305
+ +C K
Sbjct: 565 PQINCPK 571
Score = 36.6 bits (83), Expect = 0.12
Identities = 25/88 (28%), Positives = 39/88 (44%), Gaps = 12/88 (13%)
Query: 274 TCKDIDECRLNNGGCDHI-CRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDH-- 330
+C D+DEC + + +H C N GS+ CSC Y + +NC + +C ++
Sbjct: 1742 SCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPY--TGDGKNCAEPIKCKAPGNPENGH 1799
Query: 331 -----ICVNTPGSFQCLCHRGYLLYGIT 353
V +F C GY L G+T
Sbjct: 1800 SSGEIYTVGAEVTFS--CQEGYQLMGVT 1825
Score = 35.0 bits (79), Expect = 0.35
Identities = 22/78 (28%), Positives = 30/78 (38%), Gaps = 7/78 (8%)
Query: 625 CRPGQHRAGTK--CVSCPQGTYYH----GQTEQCVPCPAGTFQEREGQLSCDLCPGSDAH 678
C G + G + C +CP GTY G C+PCP G S + C + +
Sbjct: 307 CEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGY 366
Query: 679 GPLGAT-NVTTCAGQCPP 695
G T + C PP
Sbjct: 367 RASGQTCELVHCPALKPP 384
Score = 35.0 bits (79), Expect = 0.35
Identities = 18/58 (31%), Positives = 25/58 (43%), Gaps = 3/58 (5%)
Query: 749 CSPGHYYNTSIHRCIRCAMGSYQPDFRQ---NFCSRCPGNTSTDFDGSTSVAQCKNRQ 803
C G+Y + C C G+Y+P+ + C CP T GSTS C R+
Sbjct: 307 CEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCRE 364
Score = 33.5 bits (75), Expect = 1.0
Identities = 32/125 (25%), Positives = 44/125 (35%), Gaps = 25/125 (20%)
Query: 254 AATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHI----CRNTVGSFECSCKKGYKL 309
A +H P G +Q D C + C CD + C G FEC C+KGY
Sbjct: 256 ARRALHEDLPSGSFIQDDMVHCSYL--CDEGKDCCDRMGSCKCGTHTGHFECICEKGYYG 313
Query: 310 LINERNCQDIDECSFD--------RTC----DHICVNTPGSF---QCLCHRGYLLYG--- 351
+ C ++ +C D + PGS C+C GY G
Sbjct: 314 KGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTC 373
Query: 352 -ITHC 355
+ HC
Sbjct: 374 ELVHC 378
Score = 30.4 bits (67), Expect = 8.6
Identities = 20/72 (27%), Positives = 31/72 (43%), Gaps = 11/72 (15%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVN 88
+++EC ++ C A C + SY C C+ G++G CE E + G D
Sbjct: 1383 NINECQ--SNPCRNQATCVDELNSYSCKCQPGFSG--------KRCETEQSTGFNLD-FE 1431
Query: 89 IPGNYRCTCYDG 100
+ G Y DG
Sbjct: 1432 VSGIYGYVMLDG 1443
>gi|190343004 EGF-containing fibulin-like extracellular matrix
protein 2 [Homo sapiens]
Length = 443
Score = 141 bits (355), Expect = 3e-33
Identities = 108/390 (27%), Positives = 156/390 (40%), Gaps = 70/390 (17%)
Query: 97 CYDGFHLAHDGHNCLDVDECAEGNGGC--QQSCVNMMGSYECHCREGFFLSDNQHTCIQR 154
C DG+ D +C DV+EC C + C+N G Y C R ++D
Sbjct: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
Query: 155 PEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDD 214
P P C PG+E Q +C D
Sbjct: 99 P-------------------VPPAQHPNPCPPGYEPDD----------------QDSCVD 123
Query: 215 TEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFM-LQPDRK 273
++ C + A+++ CH+ CTCP G+ + P+
Sbjct: 124 VDE------------------CAQ--ALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE-- 161
Query: 274 TCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICV 333
C DIDECR C H C N GSF C C+ G++L N R+C D++EC C+ C
Sbjct: 162 -CVDIDECRYRY--CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCF 218
Query: 334 NTPGSFQCLCHRGYLLY--GITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLH 391
N+ G+F C CH+GY L+ G + C D+DECS + C++ C+N PG + C CP G L
Sbjct: 219 NSYGTFLCRCHQGYELHRDGFS-CSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLL- 276
Query: 392 WNGKDCTEPLKCQ-GSPGASKAMLSCNRSGKKDTCALTCPSRARFLPESENGFTVSCGTP 450
+ C + +C+ G+ S+A N G C T ++ SEN P
Sbjct: 277 -ATRLCQDIDECESGAHQCSEAQTCVNFHGGY-RCVDTNRCVEPYIQVSENRCLCPASNP 334
Query: 451 SPRAAPARAGHNGNSTNSNHCHEAAVLSIK 480
R P+ H + S A V I+
Sbjct: 335 LCREQPSSIVHRYMTITSERSVPADVFQIQ 364
Score = 130 bits (326), Expect = 8e-30
Identities = 70/197 (35%), Positives = 97/197 (49%), Gaps = 14/197 (7%)
Query: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVN 88
DVDEC + +C C N P SY+C C GY G C D+DEC C H CVN
Sbjct: 123 DVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYR---YCQHRCVN 179
Query: 89 IPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQ 148
+PG++RC C GF L + +C+DV+EC G C+Q C N G++ C C +G+ L +
Sbjct: 180 LPGSFRCQCEPGFQLGPNNRSCVDVNECDMG-APCEQRCFNSYGTFLCRCHQGYELHRDG 238
Query: 149 HTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFEL--TKNQRDCKLTCNYGNG 206
+C E C ++ C + C P G +C C G++L T+ +D C G
Sbjct: 239 FSCSDIDE----CSYSSYLCQYRCVNEP-GRFSCHCPQGYQLLATRLCQDID-ECESGAH 292
Query: 207 GCQ--HTCDDTEQGPRC 221
C TC + G RC
Sbjct: 293 QCSEAQTCVNFHGGYRC 309
Score = 112 bits (281), Expect = 1e-24
Identities = 91/330 (27%), Positives = 127/330 (38%), Gaps = 88/330 (26%)
Query: 24 SKAAQDVDECVEGTDNCHIDAICQNTPRSYKCI--------------------------- 56
S+ +DV+EC+ + C + C N Y C+
Sbjct: 49 SQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNP 108
Query: 57 CKSGYTGDGK-HCKDVDECERE-DNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVD 114
C GY D + C DVDEC + + DC N+PG+Y+CTC DG+ G C+D+D
Sbjct: 109 CPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKI--GPECVDID 166
Query: 115 ECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRE 174
EC CQ CVN+ GS+ C C GF L N +C+ +N + C C
Sbjct: 167 ECRYRY--CQHRCVNLPGSFRCQCEPGFQLGPNNRSCVD-----VNECDMGAPCEQRCFN 219
Query: 175 TPKGGIACECRPGFELTKNQRDCK--LTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTD 232
+ G C C G+EL ++ C C+Y + CQ+ C
Sbjct: 220 S-YGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRC-------------------- 258
Query: 233 GKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCD--H 290
VN G S C CP G+ L R C+DIDEC C
Sbjct: 259 ---------VNEPGRFS----------CHCPQGYQLLATR-LCQDIDECESGAHQCSEAQ 298
Query: 291 ICRNTVGSFEC----SCKKGYKLLINERNC 316
C N G + C C + Y + ++E C
Sbjct: 299 TCVNFHGGYRCVDTNRCVEPY-IQVSENRC 327
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.457
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,734,752
Number of Sequences: 37866
Number of extensions: 2769897
Number of successful extensions: 14802
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 217
Number of HSP's successfully gapped in prelim test: 195
Number of HSP's that attempted gapping in prelim test: 5820
Number of HSP's gapped (non-prelim): 3060
length of query: 993
length of database: 18,247,518
effective HSP length: 112
effective length of query: 881
effective length of database: 14,006,526
effective search space: 12339749406
effective search space used: 12339749406
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.